JP2012239669A - Probe and diagnostic system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To discriminate a portion to be measured from other portions in a luminal wall.SOLUTION: The probe 5 which applies excitation light to a living tissue and which receives radiation light generated from the living tissue caused by the excitation light includes: a tube 52 having a large-diameter aperture passage 52a and a small-diameter aperture passage 52b; an optical fiber 57 inserted into the large-diameter aperture passage 52a of the tube 52; an optical system 58 provided in the large-diameter aperture passage 52a for projecting the excitation light emitted from the distal end face of the optical fiber 57 to the living tissue outside the tube 52, and projecting the radiation light generated from the living tissue to the distal end face of the optical fiber 57; and a high-frequency electrode 55 inserted into the small-diameter aperture passage 52b at the distal end of the tube 52.

Description

  The present invention relates to a probe and a diagnostic system.

  Various techniques have been proposed and put to practical use in order to observe the lesion state of a living tissue. In particular, endoscopes are widely used. The endoscope is inserted into the lumen, the biological tissue on the lumen wall is illuminated by the illumination light emitted from the distal end portion of the endoscope, and the biological tissue on the lumen wall is photographed at the distal end portion of the endoscope. . An image photographed by the endoscope is transmitted to an output device such as a display device and a printing device, and is output from the output device.

  Patent Document 1 discloses an optical coherence tomography apparatus that observes a lumen wall along the circumferential direction by scanning an imaging beam (coherence light) in the circumferential direction. Specifically, the imaging beam is irradiated in the radial direction from the tip of the optical coherence tomography apparatus, and the imaging beam is scanned in the circumferential direction by rotating the tip of the optical coherence tomography apparatus. Moreover, the optical coherence tomography apparatus described in Patent Document 1 can cauterize the lumen wall with a laser beam. That is, a laser beam is irradiated radially from the tip of the optical coherence tomography device, and the tip of the optical coherence tomography device is rotated to scan the laser beam in the circumferential direction. Can be treated.

  In addition to image diagnosis using an endoscope and an optical coherence tomography apparatus, a technique has been proposed in which diagnosis is performed using radiation (for example, fluorescence) emitted from a living tissue on a lumen wall. In order to make a diagnosis using synchrotron radiation, the living tissue is irradiated with excitation light (for example, ultraviolet rays) so that the synchrotron radiation is emitted from the living tissue on the lumen wall, and the wavelength and intensity of the generated synchrotron radiation are analyzed. To do. In order to make such a diagnosis, a probe has been developed, and the probe is used for diagnosis of a disease state (for example, a disease type or an infiltration range) such as degeneration of a living tissue or cancer.

  The probe has a flexible tube, an optical fiber for excitation light, an optical fiber for emission light, and the like, and the optical fiber for excitation light and the optical fiber for emission light are held in the tube. When using the probe, the probe is inserted into the forceps opening of the endoscope, and the tip of the probe is protruded from the tip of the endoscope. When the excitation light source emits light, the excitation light is incident on the proximal end of the excitation light optical fiber, the excitation light is guided from the proximal end to the distal end by the excitation light optical fiber, and is emitted by the distal end. Thereby, excitation light is irradiated to the living tissue of the lumen wall, and emitted light is emitted from the living tissue. Radiant light emitted from the living tissue is incident on the distal end of the optical fiber for emitted light, and the emitted light is guided from the distal end to the proximal end by the optical fiber for emitted light. By measuring the wavelength and intensity of the radiated light guided to the proximal end of the radiated light optical fiber with a measuring instrument, it is possible to diagnose the presence or absence of a lesion in the living tissue on the lumen wall.

JP-T 2009-537024

  By the way, it is necessary to recognize the measurement location in the lumen wall. For example, if a lesion is confirmed as a result of measuring a part of the lumen wall with excitation light or synchrotron radiation, it is necessary to distinguish the lesion from another in order to treat the lesion after measurement. is there. In addition, when trying to measure a specific portion of the lumen wall by excitation light / radiation light, it is necessary to distinguish the specific portion from the others.

  Therefore, the problem to be solved by the present invention is to make it possible to distinguish a measurement location from other locations in the lumen wall.

  The invention according to claim 1 for solving the above-described problem is provided in a linear shape, and projects excitation light from a linear tip portion onto the living tissue, and from the living tissue due to the excitation light. In the probe for receiving generated radiated light at a linear tip portion, the probe is provided with a marking mechanism provided at the tip portion of the probe and forming a mark on the living tissue.

  The invention according to claim 2 is a tube, one or a plurality of optical fibers inserted in the tube, and the excitation light emitted from the distal end surface of the optical fiber provided at the distal end of the tube. The probe according to claim 1, further comprising: an optical system that projects onto the living tissue outside the body and projects the emitted light generated from the living tissue onto the distal end surface of the optical fiber. is there.

  The invention according to claim 3 is a multi-lumen tube in which the tube has a first hole path and a second hole path penetrating in the axial direction of the tube, and the marking mechanism is electrocauterized by a high-frequency current. A high-frequency electrode that forms a mark by a mark on the living tissue, the optical fiber is inserted into the first hole and held in the first hole, and the optical system is attached to the tip of the optical fiber. The probe according to claim 2, wherein the probe is held in the first hole path and the high-frequency electrode is inserted into the second hole path at a distal end portion of the tube.

  The invention according to claim 4 is characterized in that the tube passes through a first hole passage penetrating in an axial direction of the tube and a second hole passage penetrating from a proximal end surface of the tube to a peripheral surface near the distal end of the tube. A multi-lumen tube having a high-frequency electrode in which the marking mechanism is electrocauterized by a high-frequency current to form a mark by a burn mark on the living tissue, and the optical fiber is inserted into the first hole Held in the first hole, the optical system is held in the first hole at the tip of the optical fiber, and the high-frequency electrode is inserted into the second hole at the tip of the tube The probe according to claim 2, wherein the probe is provided.

The invention according to claim 5 further includes an inner tube, wherein the tube is a multi-lumen tube having a first hole and a second hole that penetrate in the axial direction of the tube,
The marking mechanism is a high-frequency electrode that is electrocauterized by a high-frequency current to form a mark by a mark on the living tissue, the inner tube is inserted into the first hole, and the optical fiber is the inner tube Inserted in the inner tube, held in the inner tube, the optical system is held in the inner tube at the tip of the optical fiber, and the high-frequency electrode is inserted into the second hole at the tip of the tube The probe according to claim 2, wherein the probe is provided.

  The invention according to claim 6 is the probe according to any one of claims 3 to 5, wherein the high-frequency electrode protrudes from the opening of the second hole at the tip of the tube. is there.

  According to a seventh aspect of the present invention, there is provided a high-frequency cable that is inserted into the second hole from the opening of the second hole on the proximal end surface of the tube, is connected to the high-frequency electrode, and supplies a high-frequency current to the high-frequency electrode. The probe according to any one of claims 3 to 6, further comprising:

  The invention according to claim 8 further includes an inner tube, wherein the tube is a single lumen tube having a hole that penetrates in an axial direction of the tube, and the marking mechanism is electrocauterized by a high-frequency current, A high-frequency electrode that forms a mark by a mark on the living tissue, the inner tube is inserted into the hole, the optical fiber is inserted into the inner tube and held in the inner tube, and the optical system The probe according to claim 2, wherein the probe is held in the inner tube at the tip of the optical fiber, and the high-frequency electrode is inserted into the hole at the tip of the tube. .

  The invention according to claim 9 is the probe according to claim 8, wherein the high-frequency electrode protrudes from the opening of the hole at the tip of the tube.

  According to a tenth aspect of the present invention, the tube is a single lumen tube having a hole that penetrates in the axial direction of the tube, and the marking mechanism electrocauterizes with a high-frequency current to mark a mark due to a mark. A high-frequency electrode formed on a living tissue, wherein the optical fiber is inserted into the hole and held in the hole, and the optical system is held in the hole at the tip of the optical fiber, The probe according to claim 2, wherein a high-frequency electrode is inserted into the hole at a distal end portion of the tube.

  According to an eleventh aspect of the present invention, a ring-shaped antifouling cover is provided so as to protrude inward from the inner peripheral surface of the tip opening of the tube, a holding hole penetrates the antifouling cover, and the tip of the high-frequency electrode The probe according to claim 10, wherein the probe is held by being fitted into the holding hole.

  The invention according to claim 12 is the probe according to claim 11, characterized in that the tip of the high-frequency electrode protrudes from the holding hole.

  The invention according to claim 13 further includes a high-frequency cable that is inserted into the hole from the opening of the hole in the proximal end surface of the tube, is connected to the high-frequency electrode, and supplies a high-frequency current to the high-frequency electrode. The probe according to any one of claims 8 to 12, characterized in that it is a probe.

  The invention according to claim 14 is a multi-channel wherein the tube has a first hole that penetrates in the axial direction of the tube, and a second hole that penetrates in the axial direction of the tube and distributes the dye. A lumen tube, the optical fiber is inserted into the first hole path and held in the first hole path, the optical system is held in the first hole path at the tip of the optical fiber, The marking mechanism discharges the dye circulated through the second hole path from a front end opening of the second hole path, and forms a mark by staining the dye on the living tissue. 2. The probe according to 2.

  According to a fifteenth aspect of the present invention, there is provided a first hole passage through which the tube penetrates in the axial direction of the tube, and a second passage through which a dye penetrates from a proximal end surface of the tube to a peripheral surface near the distal end of the tube. A multi-lumen tube having a hole, wherein the optical fiber is inserted into the first hole and held in the first hole, and the optical system is disposed at the tip of the optical fiber at the tip of the first optical fiber. The marking mechanism, which is held in one hole path, discharges the dye passed through the second hole path from the tip opening of the second hole path, and forms a mark on the living tissue by staining the dye. The probe according to claim 2, wherein:

  The invention according to claim 16 further includes an inner tube, wherein the tube penetrates in the axial direction of the tube, and a second hole passes through in the axial direction of the tube and circulates the dye. The inner tube is inserted into the first hole, the optical fiber is inserted into the inner tube and held in the inner tube, and the optical system is the optical fiber. The marking mechanism is held in the inner tube at the tip of the tip, and the marking mechanism discharges the dye circulated by the second hole from the tip opening of the second hole to mark the dye dyed mark. The probe according to claim 2, wherein the probe is formed on the living tissue.

  The invention according to claim 17 is characterized in that the marking mechanism has an absorbent material that closes the tip opening of the second hole and absorbs the dye discharged from the tip opening of the second hole. The probe according to any one of claims 14 to 16.

The invention according to claim 18 further comprises an inner tube, wherein the tube is a multi-lumen tube having a first hole and a second hole that penetrate in the axial direction of the tube,
The inner tube is inserted into the first hole, the optical fiber is inserted into the inner tube and held in the inner tube, and the optical system is inserted into the inner tube at the tip of the optical fiber. The marking mechanism is inserted into the second hole passage and has a dye distribution tube for distributing the dye, and the marking mechanism is configured to transfer the dye distributed by the dye distribution tube to the tip of the dye distribution tube. 3. The probe according to claim 2, wherein the probe is ejected from an opening to form a mark by staining the dye on the living tissue.

  The invention according to claim 19 further includes an inner tube, wherein the tube is a single lumen tube having a hole that penetrates in an axial direction of the tube, and the inner tube is inserted into the hole, An optical fiber is inserted into the inner tube and held in the inner tube, the optical system is held in the inner tube at the tip of the optical fiber, and the marking mechanism is inserted into the hole, A dye distribution tube through which the dye flows; and the marking mechanism discharges the dye distributed by the dye distribution tube from a front end opening of the dye distribution tube, and marks the dye by staining the dye on the living tissue The probe according to claim 2, wherein the probe is formed.

  The invention according to claim 20 is a single lumen tube in which the tube has a hole that penetrates in the axial direction of the tube, and the optical fiber is inserted into the hole and held in the hole. The optical system is held in the hole path ahead of the tip of the optical fiber, the marking mechanism is inserted into the hole path, and has a dye distribution tube through which the dye flows, and the marking mechanism includes the dye 3. The probe according to claim 2, wherein the dye distributed by the distribution tube is discharged from a tip opening of the dye distribution tube to form a mark on the living tissue by staining the dye.

  The invention according to claim 21 is characterized in that a ring-shaped antifouling cover is provided so as to protrude inward from the inner peripheral surface of the tip opening of the tube, a holding hole penetrates the antifouling cover, and the tip of the dye circulation tube The probe according to claim 20, wherein a portion is fitted and held in the holding hole.

  The invention according to claim 22 is characterized in that the marking mechanism has an absorbent material that closes the tip opening of the dye circulation tube and absorbs the dye discharged from the tip opening of the dye circulation tube. Item 22. The probe according to any one of Items 18 to 21.

  The invention according to claim 23 is the probe according to any one of claims 2 to 22, wherein the optical system includes a lens.

  The invention according to claim 24 is the probe according to any one of claims 2 to 22, wherein the optical system has a reflecting surface.

  The invention according to claim 25 is the probe according to claim 7 or 13, an excitation light source that supplies excitation light to the proximal end of the optical fiber, and is incident on the distal end of the optical fiber, and guides the optical fiber. A spectroscope for measuring the intensity of radiation emitted from the proximal end of the optical fiber for each wavelength; a high-frequency current source connected to the high-frequency cable, and supplying a high-frequency current to the high-frequency electrode via the high-frequency cable; , A diagnostic system.

  According to a twenty-sixth aspect of the present invention, the probe according to any one of the fourteenth to eighteenth aspects, an excitation light source that supplies excitation light to a proximal end of the optical fiber, and a distal end of the optical fiber are incident on the optical fiber. A spectroscope that measures the intensity of radiation emitted from the base end of the optical fiber for each wavelength, a dye distribution tube connected to the base end opening of the second hole, and the dye distribution And a dye supplier connected to the tube and configured to supply the dye to the dye distribution tube.

  According to a twenty-seventh aspect of the present invention, the probe according to any one of the nineteenth to twenty-second aspects, an excitation light source that supplies excitation light to a proximal end of the optical fiber, and incident on a distal end of the optical fiber, the optical fiber A spectroscope that measures the intensity of the emitted light emitted from the base end of the optical fiber for each wavelength, and a dye supplier that is connected to the dye distribution tube and supplies the dye to the dye distribution tube; , A diagnostic system.

According to the present invention, since the mark is formed on the living tissue by the marking mechanism provided at the distal end portion of the probe, the place where the mark is formed can be distinguished from the other place.
Moreover, since the marking mechanism is provided at the tip of the tube and the optical fiber is inserted into the tube, the positions of the marking mechanism and the optical fiber can be stabilized by applying the tube to the lumen wall. Therefore, the measurement location where the excitation light is projected by the optical system and the location where the mark is formed can be set at the same position or in the vicinity.

It is a lineblock diagram of a diagnostic system concerning a first embodiment of the present invention. It is a perspective view of the front-end | tip part of the endoscope which concerns on the same embodiment. It is sectional drawing and a perspective view of the 1st form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing of the 2nd form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing of the 3rd form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing of the 4th form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and a perspective view of the 5th form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and perspective view of the 6th form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and perspective view of the 7th form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and perspective view of the 8th form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and perspective view of the 9th form of the front-end | tip part structure of the probe which concerns on the embodiment. It is the perspective view and sectional drawing of the 10th form of the front-end | tip part structure of the probe which concern on the embodiment. It is a block diagram of the diagnostic system which concerns on 2nd embodiment of this invention. It is sectional drawing and a perspective view of the 1st form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and a perspective view of the 2nd form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and perspective view of the 3rd form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and perspective view of the 4th form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and a perspective view of the 5th form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and perspective view of the 6th form of the front-end | tip part structure of the probe which concerns on the embodiment. It is sectional drawing and perspective view of the 7th form of the front-end | tip part structure of the probe which concerns on the embodiment. It is the perspective view and sectional drawing of the 8th form of the front-end | tip part structure of the probe which concerns on the embodiment.

  EMBODIMENT OF THE INVENTION Below, the form for implementing this invention is demonstrated using drawing. However, the embodiments described below are given various technically preferable limitations for carrying out the present invention, but the scope of the present invention is not limited to the following embodiments and illustrated examples.

<First Embodiment>
〔overall structure〕
FIG. 1 is a schematic configuration diagram of a diagnostic system 1. As shown in FIG. 1, this diagnostic system 1 is a combination of an endoscope diagnostic system and a fluorescence diagnostic system. That is, the diagnostic system 1 includes an endoscope 2, an endoscope processor 3, an endoscope display monitor 4, a probe 5, a base unit 6, an output device 7 and an input device 8.

  An insertion portion 2 a of the endoscope 2 extends from the operation portion 2 b of the endoscope 2. When the diagnostic system 1 is used, the insertion portion 2a is inserted into the lumen.

  FIG. 2 is a perspective view of the distal end portion of the insertion portion 2a. As shown in FIG. 2, an electronic camera 2c is built in the distal end portion of the insertion portion 2a. As shown in FIG. 1, one end of the transmission cable 2d is connected to the endoscope processor 3, and a part of the transmission cable 2d is bridged from the endoscope processor 3 to the operation unit 2b. A part is provided inside the insertion portion 2a along the longitudinal direction of the insertion portion 2a, and the other end of the transmission cable 2d is connected to the electronic camera 2c. The transmission cable 2d transmits a signal of an image captured by the electronic camera 2c from the electronic camera 2c to the endoscope processor 3. The endoscope processor 3 outputs the transmitted image signal to the endoscope display monitor 4. The endoscope display monitor 4 inputs an image signal from the endoscope processor 3 and displays an image according to the image signal.

  As shown in FIG. 2, an air / water supply channel 2e is provided in the insertion portion 2a along the longitudinal direction of the insertion portion 2a, and an end of the air / water supply channel 2e is opened at a distal end surface of the insertion portion 2a. The end of the light guide 2f is provided on the distal end surface of the insertion portion 2a, the light guide 2f is routed inside the insertion portion 2a along the longitudinal direction of the insertion portion 2a, and the other end of the light guide 2f is the endoscope. The illumination light source of the processor 3 is connected. When the illumination light source of the endoscope processor 3 is turned on, the light guide 2f guides light emitted from the illumination light source to the tip, and the tip of the light guide 2f emits the illumination light.

  As shown in FIG. 2, a forceps channel 2g is provided in the insertion portion 2a along the longitudinal direction of the insertion portion 2a, and one end of the forceps channel 2g opens at the distal end surface of the insertion portion 2a. As shown in FIG. 1, the other end of the forceps channel 2g is opened at the operation portion 2b, and the opening at the other end is a forceps port 2h.

  As shown in FIG. 1, the probe 5 is linearly provided. The probe 5 is used transendoscopically. That is, the probe 5 is inserted into the body cavity from the forceps port 2h of the endoscope 2 through the forceps channel 2g. As shown in FIG. 2, the tube 52 of the probe 5 protrudes from the forceps channel 2g at the distal end of the insertion portion 2a. As shown in FIG. 1, a connector 53 is provided at the proximal end portion of the probe 5, and the connector 53 is connected to the base unit 6.

  The tip of the probe 5 is shown in FIG. FIG. 3A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 3B is a perspective view of the distal end portion of the probe 5. The probe 5 projects excitation light (for example, ultraviolet rays) from the linear tip, and receives radiation light (for example, fluorescence and Raman scattered light) generated due to the excitation light at the linear tip. To do.

  As shown in FIGS. 1 and 3, the probe 5 includes a flexible tube 51 (see FIG. 1), a tube 52 (see FIGS. 1 and 3), a connector 53 (see FIG. 1), and a high-frequency cable 54 (see FIG. 1). A high frequency electrode 55 (see FIG. 3), a connector 56 (see FIG. 1), one or a plurality of optical fibers 57 (see FIG. 3), an optical system 58 (see FIG. 3), and the like.

  As shown in FIG. 1, the proximal end portion of the flexible tube 51 is attached to the connector 53, and the flexible tube 51 extends from the connector 53. The proximal end portion of the tube 52 is connected to the distal end portion of the flexible tube 51. An optical system 58 is provided in the tube 52. The description of the tip portion structure of the probe 5 will be described later.

  One or a plurality of optical fibers 57 are passed through the flexible tube 51 and the tube 52 from the connector 56 to the tip of the tube 52.

  A portion close to the tip of the high-frequency cable 54 is inserted into the tube 52 from the joint portion between the tube 52 and the flexible tube 51 and passed through the tube 52 to the tip of the tube 52. A portion near the base end of the high-frequency cable 54 extends from the base end of the tube 52 and is routed to the base unit 6. A base end portion of the high frequency cable 54 is attached to the connector 56, and the connector 56 is connected to the base unit 6. A high frequency electrode 55 is connected to the tip of the high frequency cable 54.

  The base unit 6 includes an illumination light source 6a, an excitation light source 6b, a spectrometer 6c, a high-frequency current source 6d, and a computer 6e.

  The base unit 6 has a housing, and all of the illumination light source 6a, the excitation light source 6b, the spectroscope 6c, the high-frequency current source 6d, and the computer 6e are mounted in the housing. Note that one or more of the illumination light source 6a, the excitation light source 6b, the spectroscope 6c, the high-frequency current source 6d, and the computer 6e may be provided outside the casing.

  The illumination light source 6a emits illumination light (for example, visible light). The illumination light source 6a is a xenon lamp, halogen lamp, deuterium lamp, LED (light emitting diode), LD (laser diode), laser light source, or other illumination light emitting light source. When the connector 53 of the probe 5 is connected to the base unit 6, the base end surface of the optical fiber 57 faces or contacts the illumination light source 6a. When the illumination light source 6 a is turned on, the illumination light source 6 a supplies illumination light to the optical fiber 57. The illumination light emitted from the illumination light source 6a may be projected onto the optical fiber 57 by an optical system composed of a lens, a mirror, a filter, or a combination of two or more of these.

  The base end surface of the optical fiber 57 captures the illumination light of the illumination light source 6a, guides the illumination light captured by the optical fiber 57 from the base end surface of the optical fiber 57 to the distal end surface, and the distal end surface of the optical fiber 57 emits illumination light. The optical system 58 projects the illumination light emitted from the tip surface of the optical fiber 57. Thereby, the lumen around the tip of the probe 5 is illuminated.

  The excitation light source 6b emits excitation light. The excitation light source 6b is a xenon lamp, halogen lamp, deuterium lamp, LED (light emitting diode), LD (laser diode), laser light source, or other excitation light emitting light source. When the connector 53 of the probe 5 is connected to the base unit 6, the base end face of the optical fiber 57 faces or contacts the excitation light source 6b. When the excitation light source 6 b is turned on, the excitation light source 6 b supplies illumination light to the optical fiber 57. Note that the excitation light emitted from the excitation light source 6b may be projected onto the optical fiber 57 by an optical system including a lens, a mirror, a filter, or a combination of two or more thereof.

  The base end surface of the optical fiber 57 takes in the excitation light of the excitation light source 6b, the optical fiber 57 guides the excitation light from the base end surface of the optical fiber 57 to the distal end surface, and the distal end surface of the optical fiber 57 emits excitation light. The optical system 58 projects the excitation light emitted from the tip surface of the optical fiber 57. Specifically, the optical system 58 condenses the excitation light emitted by the distal end surface of the optical fiber 57 on the biological tissue on the lumen wall, or collimates the excitation light emitted by the distal end surface of the optical fiber 57, The excitation light, which is parallel light, is projected onto the living tissue on the lumen wall. When the projected excitation light is irradiated onto the living tissue on the lumen wall, the emitted light is emitted from the living tissue due to the excitation light.

  Radiant light emitted from the living tissue is projected onto the tip surface of the optical fiber 57 by the optical system 58. Specifically, the optical system 58 condenses the emitted light emitted from the living tissue on the distal end surface of the optical fiber 57 or collimates the emitted light emitted from the living tissue to convert the emitted light that is parallel light into the optical fiber 57. Projects to the front end surface. The distal end surface of the optical fiber 57 takes in the emitted light projected by the optical system 58, the optical fiber 57 guides the emitted light from the distal end surface of the optical fiber 57 to the proximal end surface, and the proximal end surface of the optical fiber 57 emits the emitted light. . When the connector 53 of the probe 5 is connected to the base unit 6, the base end face of the optical fiber 57 is connected to the spectroscope 6c, and the emitted light emitted from the base end face of the optical fiber 57 is guided to the spectroscope 6c. The emitted light emitted from the base end face of the optical fiber 57 may be projected onto the spectroscope 6c by an optical system including a lens, a mirror, a filter, or a combination of two or more of these.

When the number of optical fibers 57 is one, the optical fiber 57 serves both for pumping the excitation light and for guiding the emitted light. Further, the optical fiber 57 may also serve as an illumination light guide.
When the number of the optical fibers 57 is two, the first optical fibers 57 are for guiding the excitation light and the second optical fibers 57 are for guiding the emitted light. The first optical fiber 57 or the second optical fiber 57 may also serve as an illumination light guide.
When the number of the optical fibers 57 is three, the first optical fibers 57 are for guiding the excitation light, the second optical fibers 57 are for guiding the emitted light, and the third optical fibers 57 are for guiding the illumination light.
The number of optical fibers 57 may be four or more.

  The spectroscope 6c includes a spectroscopic element (for example, a diffraction grating and a prism) and a photodetection element (for example, an area CCD image sensor, a line CCD image sensor, an area CMOS image sensor, a line CMOS image sensor, a photodiode, and a photoelectron multiplier. Double tube, electron tube detector) and the like. The spectroscope 6c separates the emitted light received and guided by the probe 5 and measures the intensity of the emitted light for each wavelength. The spectroscope 6c outputs the measured intensity for each wavelength (hereinafter referred to as spectrum data) to the computer 6e.

  The high frequency current source 6 d generates a high frequency current and supplies the high frequency current to the high frequency cable 54. The frequency of the high-frequency current generated by the high-frequency current source 6d is 100 kHz to 10 MHz. As the high-frequency current source 6d, it is possible to use a current source of a high-frequency treatment instrument such as an electric knife, and unlike laser ablation, introduction is easy from the viewpoint of cost and space.

  The high frequency cable 54 feeds the high frequency current supplied from the high frequency current source 6d to the high frequency electrode 55 at the tip. The high-frequency electrode 55 connected to the tip of the high-frequency cable 54 is electrocauterized by a high-frequency current. That is, the high-frequency electrode 55 is a marking mechanism that electrocauterizes with a high-frequency current and forms a mark due to a mark on the living tissue of the lumen wall.

  The computer 6e includes a CPU 6f, a memory 6g, a signal processing circuit, and the like. The computer 6e inputs spectral data from the spectroscope 6c. The computer 6 e performs signal processing on the spectrum data by a signal processing circuit, generates an image representing the intensity distribution for each wavelength (hereinafter referred to as spectrum image data) from the spectrum data, and outputs the spectrum image data to the output device 7. . The computer 6e stores the spectrum data in the memory 6g.

  In addition, the computer 6e determines the presence / absence of the lesion and the degree of progression in accordance with a predetermined algorithm using the spectrum data. The computer 6e stores the determination result in the memory 6g. Further, the computer 6e generates an image representing the determination result (hereinafter referred to as determination result image data), and outputs the determination result image data to the output device 7.

  The output device 7 is a display or a printer. The output device 7 inputs the spectral image data output by the computer 6e, and displays or prints the spectral image data. The output device 7 inputs the determination result image data output by the computer 6e, and displays or prints the determination result image data.

  The input device 8 is a keyboard, a mouse, a plurality of switches, or a combination thereof. When the input device 8 is operated, the input device 8 outputs a signal corresponding to the operation content to the computer 6e.

  The computer 6e controls the illumination light source 6a, the excitation light source 6b, and the high-frequency current source 6d based on the signal input from the input device 8. For example, when the input device 8 is operated, the computer 6e turns on and off the illumination light source 6a and the excitation light source 6b. When the input device 8 is operated, the computer 6e starts and stops the high-frequency current source 6d.

[Configuration of probe tip: Part 1]
As shown in FIG. 3, the tube 52 is a multi-lumen tube, and the tube 52 has a large diameter passage 52a and a small diameter passage 52b arranged in parallel. The holes 52 a and 52 b penetrate from the distal end surface 52 c to the base end surface of the tube 52 in the axial direction of the tube 52, and both ends of the holes 52 a and 52 b are opened at both end surfaces of the tube 52, respectively. The diameter of the large diameter passage 52a is larger than the diameter of the small diameter passage 52b. In the case of the form shown in FIG. 3, the large-diameter hole 52a is the first hole and the small-diameter hole 52b is the second hole.

  The tube 52 has flexibility. However, the tube 52 is hard to some extent, and the tube 52 is difficult to bend even if the tip of the tube 52 hits the lumen wall or the like.

  The high frequency electrode 55 is provided in a thin line shape. The high-frequency electrode 55 is inserted into the small-diameter hole 52b at the tip of the tube 52, and the tip of the high-frequency electrode 55 slightly protrudes in the axial direction from the tip opening of the small-diameter hole 52b. Since the tip of the high-frequency electrode 55 protrudes from the tip opening of the small diameter hole 52b, the tip of the high-frequency electrode 55 can be abutted against the lumen wall. In addition, the number of the small diameter hole paths 52b formed in the tube 52 may be plural, the number of the high frequency electrodes 55 may be plural, and the high frequency electrodes 55 may be inserted into the small diameter hole paths 52b, respectively.

  The high frequency electrode 55 may be fixed to the tube 52, or the high frequency electrode 55 may be movable in the axial direction without being fixed to the tube 52.

  The optical fiber 57 is inserted from the flexible tube 51 into the large-diameter hole path 52 a of the tube 52 and passed through to the tip of the tube 52. The distal end portion of the optical fiber 57 is held at the distal end portion of the tube 52 in the large diameter passage 52a by a ferrule or the like. Since the optical fiber 57 and the high-frequency electrode 55 are inserted into separate holes, the optical fiber 57 can be prevented from being entangled with the high-frequency electrode 55.

  The optical system 58 includes one or a plurality of lenses, and the lens of the optical system 58 is held near the tip of the large-diameter hole 52a by a lens holder or the like, and the large-diameter hole 52a on the tip surface 52c of the tube 52 is held. The opening is closed by a lens. Therefore, the direction of the light projected by the lens of the optical system 58 is the axial direction of the tube 52. The lens of the optical system 58 may have either positive or negative refractive power.

  Since the optical system 58 includes a lens, the excitation light emitted from the distal end surface of the optical fiber 57 and the emitted light emitted from the living tissue on the lumen wall are collected or collimated by the lens of the optical system 58. Therefore, the amount of received radiated light can be increased, and more accurate and faster measurement can be performed. In addition, the performance of observation / diagnosis of a lesion by optical measurement is improved.

  The optical system 58 includes an excitation light lens that projects excitation light emitted from the distal end surface of the optical fiber 57 for guiding excitation light in the optical fiber 57, and radiated light generated from the living tissue. And a radiant light lens that projects onto the distal end surface of the optical fiber 57 for light. The optical system 58 may further include an illumination light lens that projects illumination light emitted from the distal end surface of the optical fiber 57 for guiding illumination light in the optical fiber 57.

  As shown in FIGS. 4 to 6, the direction of the light projected by the optical system 58 may be the radial direction of the tube 52.

  As shown in FIG. 4, the optical system 58 has a planar reflecting surface 58 a and a lens 58 b, the planar reflecting surface 58 a is inclined with respect to the axis of the tube 52, and the optical axis of the lens 58 b is It has become. The planar reflection surface 58a is a total reflection surface of a prism or a mirror surface of a mirror. The flat reflection surface 58a reflects the excitation light and illumination light emitted by the distal end surface of the optical fiber 57 in the radial direction of the tube 52, and the lens 58b projects the excitation light and illumination light reflected by the flat reflection surface 58a. . Since the excitation light emitted from the distal end surface of the optical fiber 57 and the emitted light emitted from the living tissue of the lumen are collected or collimated by the lens 58b, the amount of received emitted light can be increased and the accuracy can be increased.・ High-speed measurement is possible.

  As shown in FIG. 5, the optical system 58 has a plane reflection surface 58 a, and the plane reflection surface 58 a is inclined with respect to the axis of the tube 52. The planar reflection surface 58 a reflects the excitation light and illumination light emitted from the distal end surface of the optical fiber 57 in the radial direction of the tube 52.

  As shown in FIG. 6, the optical system 58 has a curved reflecting surface 58c. The curved reflecting surface 58c is a concave surface (for example, a spherical surface, a spheroid, a paraboloid). The curved reflecting surface 58c reflects excitation light and illumination light emitted from the distal end surface of the optical fiber 57 in the radial direction of the tube 52, and condenses or collimates the reflected light. Therefore, the amount of received radiated light can be increased, and more accurate and faster measurement can be performed.

  4 to 6, at least a portion of the tube 52 in the reflection direction of the flat reflecting surface 58a or the curved reflecting surface 58c is transparent as the light projecting / receiving window 52w, and the distal end opening of the large-diameter hole 52a is formed. It is blocked by the cap 52x.

  4 to 6, since the direction of the light projected by the optical system 58 is the radial direction of the tube 52, the lumen wall can be easily measured. Further, when the operator rotates the probe 5 manually or with a motor or the like, the lumen can be continuously measured in the circumferential direction, and multipoint measurement can be easily performed.

  The flexible tube 51 may be a multi-lumen tube similarly to the tube 52, or may be a single lumen tube. When the flexible tube 51 is a multi-lumen tube, the flexible tube 51 has two holes, and one hole of the flexible tube 51 communicates with the large-diameter hole 52a. The other hole path of the tube 51 may communicate with the small diameter hole path 52b. When the flexible tube 51 is a multi-lumen tube, the flexible tube 51 and the tube 52 may be integrally molded, or the flexible tube 51 and the tube 52 are molded separately and these are joined. It may be. The high frequency cable 54 may be passed from the distal end portion of the tube 52 to the proximal end portion of the flexible tube 51 instead of branching from the joint portion of the tube 52 and the flexible tube 51. In that case, the connector 56 and the connector 53 are integrated.

[Structure of probe tip: Part 2]
With reference to FIG. 7, another form of the tip of the probe 5 will be described. FIG. 7A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 7B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the embodiment shown in FIG. 7 and the embodiment shown in FIG. 3 are denoted by the same reference numerals.

  As shown in FIG. 7, the tube 52 is a flexible multi-lumen tube that is somewhat rigid, similar to the configuration shown in FIG. 3. As in the embodiment shown in FIG. 3, the large-diameter hole 52 a penetrates in the axial direction of the tube 52 from the distal end surface 52 c to the proximal end surface of the tube 52, and both ends of the large-diameter hole 52 a are opened at both end surfaces of the tube 52. doing. On the other hand, the proximal end side of the small-diameter hole 52 b opens at the proximal end surface of the tube 52, but the distal end of the small-diameter hole 52 b does not open at the distal end surface of the tube 52. The distal end of the small-diameter hole 52 b is open on the peripheral surface near the distal end of the tube 52. In the case of the embodiment shown in FIG. 7, the large diameter hole 52a is the first hole and the small diameter hole 52b is the second hole.

  A thin high-frequency electrode 55 is inserted from the flexible tube 51 into the small-diameter hole 52b of the tube 52, and the tip of the high-frequency electrode 55 slightly protrudes radially outward from the opening on the tip side of the small-diameter hole 52b. . Therefore, a mark can be easily formed on the lumen wall. Moreover, the operator can form marks in the lumen continuously in the circumferential direction by rotating the probe 5 manually or by a motor or the like.

  The form shown in FIG. 7 and the form shown in FIG. 3 are the same except for the shape of the small-diameter hole 52b and the shape of the high-frequency electrode 55 inserted therein. Even in the case of the configuration shown in FIG. 7, the optical system 58 may be configured as shown in FIGS. 4 to 6.

[Structure of probe tip: Part 3]
With reference to FIG. 8, another form of the tip of the probe 5 will be described. FIG. 8A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 8B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the embodiment shown in FIG. 8 and the embodiment shown in FIG. 3 are denoted by the same reference numerals.

  As shown in FIG. 8, the probe 5 further includes an inner tube 59.

  Similar to the embodiment shown in FIG. 3, the tube 52 is a flexible multi-lumen tube that is somewhat rigid. The holes 52 a and 52 b penetrate from the distal end surface 52 c to the base end surface of the tube 52 in the axial direction of the tube 52, and both ends of the holes 52 a and 52 b are opened at both end surfaces of the tube 52, respectively. Similar to the embodiment shown in FIG. 3, the high-frequency electrode 55 is inserted into the small-diameter hole 52b, and the tip of the high-frequency electrode 55 protrudes slightly in the axial direction from the tip opening of the small-diameter hole 52b. In the case of the form shown in FIG. 8, the large-diameter hole 52a is the first hole and the small-diameter hole 52b is the second hole. In addition, the number of the small diameter hole paths 52b formed in the tube 52 may be plural, the number of the high frequency electrodes 55 may be plural, and the high frequency electrodes 55 may be inserted into the small diameter hole paths 52b, respectively.

  The inner tube 59 is inserted into the large-diameter hole 52a, and the tip of the inner tube 59 protrudes from the tip opening of the large-diameter hole 52a. The inner tube 59 may be fixed to the tube 52, or the inner tube 59 may be movable in the axial direction without being fixed to the tube 52. The outer diameter of the inner tube 59 is larger than the diameter of the high frequency electrode 55.

  An optical fiber 57 is inserted into the inner tube 59, and the tip of the optical fiber 57 is held in the inner tube 59 by a ferrule or the like.

  The optical system 58 includes one or a plurality of lenses, the lens of the optical system 58 is held in the inner tube 59 by a lens holder or the like, and the opening at the tip of the inner tube 59 is blocked by the lens of the optical system 58. . 8, the optical system 58 may be configured as shown in FIGS. 4 to 6, and the optical system 58 may be disposed in the inner tube 59. In that case, at least a portion of the inner tube 59 in the reflection direction of the flat reflecting surface 58a or the curved reflecting surface 58c is transparent as a light projecting and receiving window, and the tip opening of the large-diameter hole 52a is closed by a cap.

  The form shown in FIG. 8 is the same as that shown in FIG. 3 except that the distal end portion of the probe 5 has a double tube structure and the optical fiber 57 and the optical system 58 are disposed in the inner tube 59. Are the same.

[Structure of probe tip: Part 4]
With reference to FIG. 9, another form of the tip of the probe 5 will be described. FIG. 9A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 9B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the embodiment shown in FIG. 9 and the embodiment shown in FIG.

  As shown in FIG. 9, the outer diameter of the inner tube 59 into which the optical fiber 57 is inserted is smaller than the diameter of the high frequency electrode 55, the inner tube 59 is inserted into the small diameter hole 52 b of the tube 52, and the high frequency electrode 55 is connected to the tube 52. Is inserted into the large-diameter hole 52a. In the case of the form shown in FIG. 9, the small diameter hole 52b is a first hole and the large diameter hole 52a is a second hole.

  The form shown in FIG. 9 is the same as the form shown in FIG. 8 except as described above. 9, the optical system 58 may be configured as shown in FIGS. 4 to 6, and the optical system 58 may be disposed in the inner tube 59.

[Structure of probe tip: Part 5]
With reference to FIG. 10, another form of the tip of the probe 5 will be described. FIG. 10A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 10B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the embodiment shown in FIG. 10 and the embodiment shown in FIG. 9 are denoted by the same reference numerals.

  As shown in FIG. 10, the tube 52 is a multi-lumen tube, the number of small-diameter holes 52 b is 2, and these small-diameter holes 52 b penetrate from the distal end surface 52 c of the tube 52 to the proximal end surface. Further, the number of inner tubes 59 is two, and the inner tubes 59 are respectively inserted into the small diameter holes 52b. The number of optical systems 58 is two, and the optical systems 58 are respectively provided in the inner tubes 59. Even in the case of the form shown in FIG. 10, the optical system 58 may be configured as shown in FIGS. 4 to 6, and the optical system 58 may be disposed in the inner tube 59. Further, the number of the small diameter holes 52b is three or more, the number of units including the inner tube 59, the optical system 58, and the optical fiber 57 is three or more, and these units are inserted into the small diameter holes 52b, respectively. Good.

  An optical fiber 57 is inserted into each inner tube 59. The number of optical fibers 57 inserted into one inner tube 59 may be the same as or different from the number of optical fibers 57 inserted into the other inner tube 59.

In the case of the form shown in FIG. 10, the small diameter hole 52b is the first hole and the large diameter hole 52a is the second hole.
The form shown in FIG. 10 is the same as the form shown in FIG. 9 except as described above.

[Structure of probe tip: Part 6]
With reference to FIG. 11, another form of the tip of the probe 5 will be described. FIG. 11A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 11B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the form shown in FIG. 11 and the form shown in FIG. 8 are denoted by the same reference numerals.

  As shown in FIG. 11, the tube 52 is a single lumen tube, the large diameter hole 52a penetrates from the distal end surface 52c of the tube 52 to the base end surface, and a hole having a smaller diameter than the large diameter hole 52a. The tube 52 is not formed.

  The thin high-frequency electrode 55 is inserted from the flexible tube 51 into the large-diameter hole 52a of the tube 52, and the tip of the high-frequency electrode 55 protrudes slightly from the opening on the tip side of the large-diameter hole 52a.

  As in the case of the embodiment shown in FIG. 8, an inner tube 59 that is thicker than the high-frequency electrode 55 is inserted into the large-diameter hole 52 a, and the optical fiber 57 and the optical system 58 are disposed in the inner tube 59. 11, the optical system 58 may be configured as shown in FIGS. 4 to 6, and the optical system 58 may be disposed in the inner tube 59. The high frequency electrode 55 may be thicker than the inner tube 59, or the high frequency electrode 55 and the inner tube 59 may be equal in thickness.

  The form shown in FIG. 11 is the same as the form shown in FIG. 8 except as described above.

[Structure of probe tip: Part 7]
With reference to FIG. 12, another form of the tip of the probe 5 will be described. FIG. 12A is a perspective view showing a state in which the tip of the probe 5 is partially broken, and FIG. 12B is a cross-sectional view of the tip of the probe 5. Parts corresponding to each other between the form shown in FIG. 12 and the form shown in FIG. 11 are denoted by the same reference numerals.

  As shown in FIG. 12, the tube 52 is a single lumen tube, the large diameter hole 52a penetrates from the distal end surface 52c of the tube 52 to the base end surface, and a hole having a smaller diameter than the large diameter hole 52a. The tube 52 is not formed.

  A second tube 60 is attached to the tip of the probe 5. The second tube 60 is a single lumen tube, and the shape of the second tube 60 is a cylindrical shape having a hollow (hole 60a), and the hole 60a penetrates in the axial direction from the proximal end surface to the distal end surface of the second tube 60. doing. The proximal end of the second tube 60 is joined to the distal end of the tube 52, and the second tube 60 extends forward from the distal end of the tube 52. The second tube 60 is harder than the tube 52, and even if the tip of the second tube 60 hits the lumen wall or the like, the second tube 60 is difficult to bend. The second tube 60 is an antifouling hood that antifouls the optical fiber 57 and the optical system 58.

  A ring-shaped antifouling cover 61 is provided so as to protrude from the inner peripheral surface to the inside over the entire inner periphery of the tip of the second tube 60. Since the antifouling cover 61 is formed in a ring shape, an opening 62 which is a part of the hole 60 a is formed inside the antifouling cover 61. The opening 62 may be closed by a transparent member. A plurality of holding holes 63 pass through the antifouling cover 61. These holding holes 63 are arranged in the circumferential direction.

  A substantially cylindrical lens holding frame 70 is fitted into the tube 52. The lens holding frame 70 protrudes from the distal end surface 52 c of the tube 52 and is fitted into the second tube 60. An optical system 58 that is a lens is held inside the tip of the lens holding frame 70. A ferrule 72 is fixed inside the lens holding frame 70 and behind the optical system 58. Among the plurality of optical fibers 57, the light projecting optical fiber 57 a and the light receiving optical fiber 57 b are fixed to the ferrule 72, and the tip surfaces of the light projecting optical fiber 57 a and the light receiving optical fiber 57 b are opposed to the optical system 58. The light projecting optical fiber 57 a guides the excitation light, and the excitation light emitted from the front end surface of the light projecting optical fiber 57 a is projected by the optical system 58 and passes through the opening 62. The emitted light emitted from the living tissue by the excitation light passes through the opening 62, and the emitted light is collected or collimated by the optical system 58 on the distal end surface of the light receiving optical fiber 57b. The optical fiber 57b for receiving light guides radiated light.

  A plurality of grooves 71 are formed on the outer peripheral surface of the lens holding frame 70. These grooves 71 extend in a direction parallel to the axis. Further, these grooves 71 are arranged in the circumferential direction along the outer peripheral surface of the lens holding frame 70 in accordance with the holding holes 63.

  Of the plurality of optical fibers 57, the illumination optical fiber 57 c is fitted into the groove 71, and the illumination optical fiber 57 c is laid along the groove 71. These illumination optical fibers 57c protrude from the groove 71 and are inserted into the second tube 60, the distal end portion of the illumination optical fiber 57c is inserted into the holding hole 63, and the distal end surface of the illumination optical fiber 57c is exposed. Therefore, the tip portions of the illumination optical fibers 57c are arranged in the circumferential direction. Bright illumination can be realized by a plurality of illumination optical fibers 57c.

  The high frequency electrode 55 is fitted in the groove 71, and the high frequency electrode 55 is laid along the groove 71. The high frequency electrode 55 protrudes from the groove 71 and is inserted into the second tube 60, and the tip of the high frequency electrode 55 is inserted into the holding hole 63. The tip of the high frequency electrode 55 protrudes from the holding hole 63.

  The form shown in FIG. 12 is the same as the form shown in FIG. 11 except as described above.

[Usage procedure]
A procedure for using the diagnosis using the diagnosis system 1 will be described.
First, the operator connects the connectors 53 and 56 of the probe 5 to the base unit 6 and checks the operation of the probe 5. For example, it is confirmed whether or not illumination light or excitation light is projected from the tip of the probe 5 by turning on the illumination light source 6a or the excitation light source 6b, or the high frequency current source 6d is turned on to apply high frequency to the high frequency electrode 55. Check whether or not current is generated.

  Next, an endoscope in which the illumination light source of the endoscope processor 3 is turned on, the operator inserts the insertion portion 2a of the endoscope 2 into the lumen, and an image captured by the electronic camera 2c is displayed. While looking at the display monitor 4, the distal end of the insertion portion 2a is made to reach the target location. Then, the operator determines whether or not optical diagnosis is necessary based on the image displayed on the endoscope display monitor 4, and if necessary, the operator inserts the probe 5 into the forceps port 2h, The tip of the probe 5 is projected from the forceps channel 2g at the tip of 2a. The operator moves the probe 5 in the axial direction to finely adjust the position of the distal end portion of the probe 5 and touch the distal end of the probe 5 to the measurement location on the lumen wall. Specifically, the tube 52 or the second tube 60 is applied to the measurement location, and the tip of the high-frequency electrode 55 is pressed to the measurement location on the lumen wall. Even when the lumen moves like a peristaltic motion, the position of the tip of the probe 5 is fixed by applying the hard tube 52 or the second tube 60 to the lumen wall. Since the protruding amount of the tip of the high-frequency electrode 55 is small, there is no possibility that the lumen wall is damaged by the tip of the high-frequency electrode 55.

Next, the illumination light source of the endoscope processor 3 is turned off.
Next, when the operator operates the input device 8, the computer 6e turns on the excitation light source 6b, the excitation light emitted from the excitation light source 6b is incident on the base end surface of the optical fiber 57, and the incident excitation light is incident on the optical fiber. The guided excitation light is emitted from the distal end surface of the optical fiber 57, and the emitted excitation light is projected onto the living tissue of the lumen by the optical system 58. As a result, emitted light is emitted from the living tissue of the lumen. The emitted light emitted from the living tissue is incident on the distal end surface of the optical fiber 57, the incident emitted light is guided to the proximal end surface by the optical fiber 57, and the guided emitted light is emitted from the proximal end surface of the optical fiber 57. Light emitted from the base end face of the optical fiber 57 enters the spectroscope 6c.

  The emitted light incident on the spectrometer 6c is dispersed by the spectrometer 6c, and the intensity of each wavelength of the emitted light is measured by the spectrometer 6c. Then, the computer 6e determines the presence / absence and progress of the lesion from the spectrum data measured by the spectroscope 6c, and the determination result and spectrum data are output by the output device 7. When the operator operates the input device 8, the computer 6e turns off the excitation light source 6b.

When the operator looks at the output of the output device 7 and determines that there is a lesion at the measurement location or the progress of the lesion is high, the worker forms a mark at the measurement location.
Specifically, first, when the operator operates the input device 8, the computer 6e turns on the illumination light source 6a. If it does so, the periphery of the front-end | tip part of the probe 5 will be illuminated, and the image displayed on the endoscope display monitor 4 will become bright. Next, when the operator operates the input device 8, the computer 6e activates the high-frequency current source 6d. Then, the high frequency current is supplied from the high frequency current source 6d to the high frequency electrode 55 via the high frequency cable 54, the measurement location is electrocauterized by the tip of the high frequency electrode 55, and a mark (mark) is formed at the measurement location. . Even when a high-frequency current is applied to the high-frequency electrode 55, a scorch due to electrocautery can be formed on the lumen wall without drilling a measurement location on the lumen wall. The high frequency current source 6d is not activated by the operation of the input device 8, but when the determination result by the computer 6e indicates that there is a lesion, or when the progress of the lesion is equal to or greater than a predetermined threshold, the computer 6e The current source 6d may be activated.

  Once the measurement location is marked, when the operator operates the input device 8, the computer 6e stops the high-frequency current source 6d. If there is no lesion at the measurement location or the progression of the lesion is low, marking is not performed.

  When performing measurement at another location, the operator changes the measurement location by moving the insertion portion 2a of the endoscope 2 or the probe 5 in the axial direction while looking at the endoscope display monitor 4. Next, when the operator operates the input device 8, the computer 6e turns off the illumination light source 6a. Thereafter, in the same manner as described above, the excitation light source 6b is turned on again, the presence / absence and progress of the lesion at the measurement location are measured, the high-frequency current source 6d is activated as necessary, and the focus is traced to the measurement location. wear.

  As described above, after the measurement is performed once or a plurality of times, the operator pulls out the probe 5 from the forceps port 2h. When the measurement location is marked, the illumination light source of the endoscope processor 3 is turned on, the operator inserts the forceps into the forceps port 2h, and the forceps is inserted into the forceps channel 2g at the distal end of the insertion portion 2a. Protrude from. Then, the operator removes the measurement site (lesioned portion) with the focus by using forceps while looking at the endoscope display monitor 4. Since the lesion has a scar, the lesion can be identified and the lesion can be accurately removed.

〔effect〕
According to the above embodiment, the following effects can be obtained.

(1) Since the high-frequency electrode 55 is provided at the distal end portion of the probe 5, a mark (mark) can be formed on the lumen wall. The measurement location and other locations can be identified by the trace.

(2) Since the high-frequency electrode 55 is provided at the distal end portion of the probe 5, a mark (mark) can be formed on the lumen wall without pulling out the probe 5 from the forceps channel 2g of the insertion portion 2a. it can. In particular, the location to be marked can be in the same position as the measurement location or in the vicinity thereof.

(3) Since the high frequency electrode 55 is accommodated in the tube 52 or the second tube 60, there is no possibility that the lumen wall is damaged by the tip of the high frequency electrode 55.

(4) The high-frequency electrode 55 forms a scar on the lumen wall by cauterization, and does not cut the lumen wall. Therefore, the protrusion amount of the tip of the high-frequency electrode 55 can be suppressed to a necessary minimum. Since the protruding amount of the high frequency electrode 55 is small, there is no possibility that the lumen wall is damaged by the tip of the high frequency electrode 55.

(5) Since the optical system 58 has a light condensing function or a collimating function, the amount of emitted light and the amount of received light are high and the measurement accuracy is high even if the distal end surface of the optical fiber 57 does not abut against the living tissue on the lumen wall. Since the distal end surface of the optical fiber 57 does not have to abut against the living tissue on the lumen wall, the lumen wall is not damaged by the optical fiber 57.

(6) Since the tip of the optical fiber 57 is accommodated in the tube 52 or the second tube 60, the lumen wall is not damaged by the optical fiber 57.

(7) Since the lumen wall is not damaged by the tip of the high frequency electrode 55, the high frequency electrode 55 can be made thin. Since the high-frequency electrode 55 is thin, even when a high-frequency current is passed through the high-frequency electrode 55, a scorch due to electrocautery can be formed on the lumen wall without drilling a measurement location on the lumen wall.

(8) Since the high-frequency electrode 55 is thin, the space in the tube 52 and the second tube 60 can be effectively used for installing the optical fiber 57 and the optical system 58.

(9) Since the tube 52 and the second tube 60 are hard, the position of the tip of the probe 5 is fixed by pressing against the tube 52 and the second tube 60. Therefore, it is difficult for the position to mark the mark to deviate from the measurement location.

<Second Embodiment>
〔overall structure〕
FIG. 13 is a schematic configuration diagram of the diagnostic system 1A. Parts corresponding to each other between the diagnostic system 1A shown in FIG. 13 and the diagnostic system 1 shown in FIG.

  In the diagnostic system 1 shown in FIG. 1, the high-frequency current source 6d is built in the base unit 6, but in the diagnostic system 1A shown in FIG. 13, the dye supplier 6h is built in the base unit 6 or is externally attached. ing. The dye supplier 6 h has a syringe, and the syringe supplies a liquid dye to the probe 5. Alternatively, the dye supplier 6h includes a dye storage container and a pump, and the dye stored in the dye storage container is supplied to the probe 5 by the pump. Alternatively, the dye supply unit 6h has a dye storage container and a compressor, and the dye stored in the dye storage container is pumped to the probe 5 by the compressor.

  When the dye supplier 6h automatically performs a supply operation using a motor or the like, the dye supplier 6h is controlled by the computer 6e.

  The dye supplied by the dye supplier 6h is indigo carmine, methylene blue, crystal violet, Congo red, or other pigment dyes.

  The diagnostic system 1A shown in FIG. 13 and the diagnostic system 1 shown in FIG. 1 include an endoscope 2, an endoscope processor 3, an endoscope display monitor 4, a probe 5, an illumination light source 6a, an excitation light source 6b, and a computer 6e. The output device 7 and the input device 8 are the same.

  In the diagnostic system 1 </ b> A shown in FIG. 13, the probe 5 has a flexible dye distribution tube 54 </ b> A instead of the high-frequency cable 54. The proximal end portion of the dye distribution tube 54A is connected to the dye supplier 6h. The distal end portion of the dye distribution tube 54A is connected to the proximal end portion of the tube 52, or a portion closer to the distal end of the dye distribution tube 54A is inserted into the tube 52 from the proximal end portion of the tube 52 and passed to the distal end portion of the tube 52. ing. The dye feeder 6h injects the dye into the proximal end portion of the dye distribution tube 54A, and the dye injected into the proximal end portion of the dye distribution tube 54A is distributed to the distal end portion of the dye distribution tube 54A through the dye distribution tube 54A. .

[Configuration of probe tip: Part 1]
With reference to FIG. 14, the form of the front-end | tip part of the probe 5 is demonstrated. FIG. 14A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 14B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the form shown in FIG. 14 and the form shown in FIG. 3 are denoted by the same reference numerals.

  As shown in FIG. 14, the tube 52 of the probe 5 is a flexible multi-lumen tube that is somewhat rigid, as in the embodiment shown in FIG. 3, and the tube 52 includes a large diameter passage 52 a and a small diameter passage 52 b. Have. The holes 52 a and 52 b penetrate from the distal end surface 52 c to the base end surface of the tube 52 in the axial direction of the tube 52, and both ends of the holes 52 a and 52 b are opened at both end surfaces of the tube 52, respectively. In the case of the form shown in FIG. 14, the large-diameter hole 52a is the first hole and the small-diameter hole 52b is the second hole.

  At the proximal end portion of the tube 52, the distal end portion of the dye circulation tube 54A is connected to the proximal end opening of the small diameter hole 52b. Note that the distal end portion of the dye circulation tube 54A may be inserted into the proximal end opening of the small diameter hole 52b, or may be connected to the proximal end of the small diameter hole 52b by a pipe joint or the like.

  When the dye is supplied to the dye distribution tube 54A by the dye supply unit 6h, the dye that has passed through the dye distribution tube 54A is injected into the proximal end opening of the small-diameter hole 52b, and the dye is small-diameter hole 52b through the small-diameter hole 52b. From the base end opening to the tip opening of the small diameter hole 52b, and the dye is discharged from the tip opening of the small diameter hole 52b. The dye discharged from the tip opening of the small-diameter hole 52b adheres to the living tissue on the lumen wall, and a mark formed by dye staining is formed on the living tissue. That is, in the form shown in FIG. 14, the small diameter hole 52b is a marking mechanism.

  In the form shown in FIG. 14, the high-frequency electrode is not inserted into the small diameter passage 52b, the dye flows through the small diameter passage 52b, and the tip of the dye distribution tube 54A is connected to the base end of the small diameter passage 52b. Except for this, the configuration is the same as that shown in FIG.

  Even in the case of the form shown in FIG. 14, the optical system 58 may be configured as shown in FIGS. 4 to 6.

[Configuration of probe tip: Part 2]
With reference to FIG. 15, the form of the front-end | tip part of the probe 5 is demonstrated. FIG. 15A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 15B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the form shown in FIG. 15 and the form shown in FIG. 14 are denoted by the same reference numerals.

  In the form shown in FIG. 15, the marking mechanism has an absorbent material 80 such as a sponge that absorbs the dye, and the tip opening of the small-diameter hole 52 b is blocked by the absorbent material 80. The absorbent 80 protrudes from the small diameter hole 52b. The dye discharged from the tip opening of the small diameter passage 52b is absorbed by the absorbent 80. When the absorbent material 80 comes into contact with the living tissue on the lumen wall, a mark formed by dye staining is formed on the living tissue.

  The form shown in FIG. 15 is the same as the form shown in FIG. 14 except that the absorbent material 80 is provided at the tip opening of the small-diameter hole 52b. In the case of the embodiment shown in FIG. 15, the large diameter hole 52a is the first hole and the small diameter hole 52b is the second hole.

[Configuration of probe tip: Part 3]
With reference to FIG. 16, the form of the front-end | tip part of the probe 5 is demonstrated. FIG. 16A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 16B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the embodiment shown in FIG. 16 and the embodiment shown in FIG. 7 are denoted by the same reference numerals.

  As shown in FIG. 16, the tube 52 is a rigid multi-lumen tube, and the large-diameter hole 52 a penetrates from the distal end surface 52 c to the proximal end surface of the tube 52 in the axial direction of the tube 52, as in the embodiment shown in FIG. In addition, both ends of the large-diameter hole 52 a are opened at both end surfaces of the tube 52. On the other hand, the proximal end side of the small diameter hole 52 b opens at the proximal end surface of the tube 52, and the distal end side of the small diameter hole 52 b opens at the peripheral surface near the distal end of the tube 52. In the case of the form shown in FIG. 16, the large diameter hole 52a is the first hole and the small diameter hole 52b is the second hole.

  On the proximal end side of the tube 52, the distal end of the dye circulation tube 54A is connected to the proximal end of the small diameter hole 52b. Note that the distal end portion of the dye circulation tube 54A may be inserted into the proximal end opening of the small diameter hole 52b, or may be connected to the proximal end of the small diameter hole 52b by a pipe joint or the like.

  In the form shown in FIG. 16, the small-diameter hole 52b is a marking mechanism. When the dye is supplied to the small diameter hole 52b via the dye distribution tube 54A by the dye supply unit 6h, the dye that has flowed to the opening on the front end side of the small diameter hole 52b is discharged in the radial direction. As the discharged dye adheres to the living tissue on the lumen wall, a mark formed by dye staining is formed on the living tissue.

  In the embodiment shown in FIG. 16, the high-frequency electrode is not inserted into the small-diameter hole 52b, the dye flows through the small-diameter hole 52b, and the tip of the dye distribution tube 54A is connected to the proximal end of the small-diameter hole 52b. (Or that the dye distribution tube 54A is inserted into the small-diameter hole 52b) is the same as the configuration shown in FIG.

  Also in the case of the form shown in FIG. 16, the opening on the front end side of the small diameter hole 52b may be blocked by the absorbent material. In the case of the form shown in FIG. 16, the optical system 58 may be configured as shown in FIGS.

[Configuration of probe tip: Part 4]
With reference to FIG. 17, the form of the front-end | tip part of the probe 5 is demonstrated. FIG. 17A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 17B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the embodiment shown in FIG. 17 and the embodiment shown in FIG. 8 are denoted by the same reference numerals.

  As shown in FIG. 17, the inner tube 59 is inserted into the large-diameter hole 52 a of the hard tube 52 and the optical fiber 57 is inserted into the inner tube 59, as in the case of the configuration shown in FIG. 8. The optical system 58 is disposed in the inner tube 59 and is held in the inner tube 59. On the proximal end side of the tube 52, the distal end of the dye circulation tube 54A is connected to the proximal end of the small diameter hole 52b. Note that the distal end portion of the dye circulation tube 54A may be inserted into the proximal end opening of the small diameter hole 52b, or may be connected to the proximal end of the small diameter hole 52b by a pipe joint or the like.

  In the case of the form shown in FIG. 17, the small diameter hole 52b is a marking mechanism. When the dye is supplied to the small diameter hole 52b via the dye distribution tube 54A by the dye supply unit 6h, the dye that has flowed to the opening on the front end side of the small diameter hole 52b is discharged in the radial direction. As the discharged dye adheres to the living tissue on the lumen wall, a mark formed by dye staining is formed on the living tissue.

  In the form shown in FIG. 17, the high-frequency electrode is not inserted into the small-diameter hole 52b, the dye flows through the small-diameter hole 52b, and the tip of the dye distribution tube 54A is connected to the base end of the small-diameter hole 52b. (Or that the dye distribution tube 54A is inserted into the small-diameter hole 52b), the configuration is the same as that shown in FIG. In the case of the form shown in FIG. 17, the large diameter hole 52a is the first hole and the small diameter hole 52b is the second hole.

  In the case of the form shown in FIG. 17 as well, as in the case of the form shown in FIG. 15, the tip opening of the small diameter hole 52b may be blocked by the absorbent material. In the case of the form shown in FIG. 17, the optical system 58 may be configured as shown in FIGS. 4 to 6, and the optical system 58 may be disposed in the inner tube 59. In the case of the form shown in FIG. 17 as well, as in the case of the form shown in FIG. 16, the distal end side opening of the small diameter hole 52 b may open on the peripheral surface of the tube 52.

  Note that the number of the small-diameter holes 52b may be plural, the distal end portion of the dye circulation tube 54A may be branched, and the branched branch portion of the dye circulation tube 54A may be connected to the base ends of the multiple small-diameter holes 52b. . Further, the number of the small diameter holes 52b is plural, the dye distribution tube 54A is branched, the branched branches of the dye distribution tube 54A are respectively inserted into the plurality of small diameter holes 52b, and the tips of the branches are small diameter holes. You may protrude from the front-end | tip opening of 52b.

[Configuration of probe tip: Part 5]
With reference to FIG. 18, the form of the front-end | tip part of the probe 5 is demonstrated. FIG. 18A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 18B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the form shown in FIG. 18 and the form shown in FIG. 9 are denoted by the same reference numerals.

  As shown in FIG. 18, the inner tube 59 into which the optical fiber 57 is inserted is inserted into the small-diameter hole 52 b of the tube 52, as in the embodiment shown in FIG. 9. Further, the dye circulation tube 54A is inserted into the large diameter hole 52a from the base end opening to the tip opening of the large diameter hole 52a, and the tip of the dye distribution tube 54A protrudes from the tip opening of the large diameter hole 52a.

  When the dye is supplied to the dye distribution tube 54A by the dye supply device 6h, the dye flows from the base end to the front end of the dye distribution tube 54A by the dye distribution tube 54A, and the passed dye is discharged from the tip opening of the dye distribution tube 54A. Is done. The dye discharged from the tip opening of the dye circulation tube 54A adheres to the living tissue on the lumen wall, and a mark formed by dye staining is formed on the living tissue. That is, in the case of the form shown in FIG. 18, the dye distribution tube 54A is a marking mechanism.

  The dye distribution tube 54 </ b> A may be fixed to the tube 52, or the dye distribution tube 54 </ b> A may be movable in the axial direction without being fixed to the tube 52. Note that the tip of the dye distribution tube 54A may be connected to the base end of the large-diameter hole 52a without being inserted into the large-diameter hole 52a.

  In the form shown in FIG. 18, the high-frequency electrode is not inserted into the large-diameter hole 52a, and the dye distribution tube 54A is inserted into the large-diameter hole 52a instead of the high-frequency electrode (or the dye distribution tube 54A). 9 except that the tip is connected to the proximal end of the large diameter passage 52a) and the dye flows through the dye distribution tube 54A (or the dye distribution tube 54A and the large diameter passage 52a). It is the same. In the case of the form shown in FIG. 18, the small diameter hole 52b is the first hole and the large diameter hole 52a is the second hole.

  Also in the case of the form shown in FIG. 18, as in the case of the form shown in FIG. 15, the tip opening of the dye circulation tube 54 </ b> A may be blocked by the absorbent material. In the case of the configuration shown in FIG. 18, the optical system 58 may be configured as shown in FIGS. 4 to 6, and the optical system 58 may be disposed in the inner tube 59.

[Configuration of probe tip: Part 6]
With reference to FIG. 19, the form of the front-end | tip part of the probe 5 is demonstrated. FIG. 19A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 19B is a perspective view of the distal end portion of the probe 5. Portions corresponding to each other between the embodiment shown in FIG. 19 and the embodiment shown in FIG. 10 are denoted by the same reference numerals.

  As shown in FIG. 19, similarly to the embodiment shown in FIG. 10, the number of small-diameter holes 52b of the tube 52 is 2, the number of inner tubes 59 is 2, and the inner tube 59 is connected to the small-diameter hole 52b. Has been inserted. The number of optical systems 58 is two, and the optical systems 58 are respectively provided in the inner tubes 59. One or a plurality of optical fibers 57 are inserted into the inner tube 59. The number of units including the inner tube 59, the optical system 58, and the optical fiber 57 is three or more, and the number of the small diameter holes 52b is three or more, and these units are inserted into the small diameter holes 52b. Good.

  A dye distribution tube 54A is inserted into the large diameter hole 52a from the proximal end opening to the distal end opening of the large diameter hole 52a. The dye distribution tube 54 </ b> A may be fixed to the tube 52, or the dye distribution tube 54 </ b> A may be movable in the axial direction without being fixed to the tube 52. The tip of the dye distribution tube 54A may be connected to the base end of the large diameter passage 52a without being inserted into the large diameter passage 52a. In the case of the form shown in FIG. 19, the small diameter hole 52b is the first hole and the large diameter hole 52a is the second hole.

  In the case of the form shown in FIG. 19, the dye distribution tube 54A is a marking mechanism. Accordingly, when the dye is supplied to the dye distribution tube 54A by the dye supply device 6h, the dye is discharged from the front end opening of the dye distribution tube 54A. The discharged dye adheres to the living tissue on the lumen wall, and a mark formed by dye staining is formed on the living tissue.

  In the embodiment shown in FIG. 19, the high-frequency electrode is not inserted into the large-diameter hole 52a, and the dye distribution tube 54A is inserted into the large-diameter hole 52a instead of the high-frequency electrode (or the dye distribution tube 54A). 10 except that the tip is connected to the proximal end of the large diameter passage 52a) and the dye flows through the dye distribution tube 54A (or the dye distribution tube 54A and the large diameter passage 52a). It is the same.

  In the case of the form shown in FIG. 19, as in the case of the form shown in FIG. 15, the tip opening of the dye circulation tube 54 </ b> A may be blocked by the absorbent material. In the case of the form shown in FIG. 19, the optical system 58 may be configured as shown in FIGS. 4 to 6, and the optical system 58 may be disposed in the inner tube 59.

[Structure of probe tip: Part 6]
With reference to FIG. 20, another form of the tip of the probe 5 will be described. FIG. 20A is a cross-sectional view of the distal end portion of the probe 5, and FIG. 20B is a perspective view of the distal end portion of the probe 5. Parts corresponding to each other between the form shown in FIG. 20 and the form shown in FIG. 11 are denoted by the same reference numerals.

  As shown in FIG. 20, the tube 52 is a single lumen tube, the large-diameter hole 52 a is formed in the tube 52, and the inner tube 59 into which the optical fiber 57 is inserted is the tube 52, as in the embodiment shown in FIG. 11. It is inserted into the large diameter hole 52a. The dye circulation tube 54A is also inserted into the large diameter hole 52a from the base end opening to the tip opening of the large diameter hole 52a, and the tips of the dye distribution tube 54A and the inner tube 59 protrude from the tip opening of the large diameter hole 52a. .

  In the form shown in FIG. 20, the dye distribution tube 54A is a marking mechanism. Accordingly, when the dye is supplied to the dye distribution tube 54A by the dye supplier 6h, the dye that has flowed from the base end to the tip end of the dye distribution tube 54A is discharged from the tip opening of the dye distribution tube 54A. The dye discharged from the tip opening of the dye circulation tube 54A adheres to the living tissue on the lumen wall, and a mark formed by dye staining is formed on the living tissue.

  The dye distribution tube 54A and the inner tube 59 may be fixed to the tube 52, or the dye distribution tube 54A and the inner tube 59 may be movable in the axial direction without being fixed to the tube 52. Good.

  The form shown in FIG. 20 is that the high-frequency electrode is not inserted into the large-diameter hole 52a, the dye distribution tube 54A is inserted into the large-diameter hole 52a instead of the high-frequency electrode, and the dye is the dye distribution tube 54A. 10 is the same as that shown in FIG.

  Also in the case of the form shown in FIG. 20, similarly to the form shown in FIG. 15, the tip opening of the dye circulation tube 54A may be blocked by the absorbent material. In the case of the form shown in FIG. 20, the optical system 58 may be configured as shown in FIGS. 4 to 6, and the optical system 58 may be disposed in the inner tube 59.

[Structure of probe tip: Part 7]
With reference to FIG. 21, another form of the tip of the probe 5 will be described. FIG. 21A is a perspective view showing a state in which the tip of the probe 5 is partially broken, and FIG. 21B is a cross-sectional view of the tip of the probe 5. Parts corresponding to each other between the form shown in FIG. 21 and the form shown in FIG. 12 are denoted by the same reference numerals.

  As shown in FIG. 21, similarly to the embodiment shown in FIG. 12, the tube 52 and the second tube 60 are single lumen tubes, and the proximal end of the second tube 60 is connected to the distal end of the tube 52 to prevent ring-shaped protection. A dirty cover 61 is formed on the inner peripheral surface of the tip of the second tube 60, and a plurality of holding holes 63 are formed in the antifouling cover 61. Similarly to the configuration shown in FIG. 12, the substantially cylindrical lens holding frame 70 is fitted into the tube 52 and the second tube 60, and the optical system 58 that is a lens is held inside the tip of the lens holding frame 70. ing. 12, the ferrule 72 is fixed inside the lens holding frame 70 and behind the optical system 58, and the light projecting optical fiber 57a and the light receiving optical fiber 57b are fixed to the ferrule 72. . Similarly to the embodiment shown in FIG. 12, the illumination optical fiber 57 c is fitted into the groove 71 of the lens holding frame 70, and the tip of the illumination optical fiber 57 c is inserted into the holding hole 63.

  Instead of the high-frequency electrode, a dye circulation tube 54A is inserted into the tube 52 and the second tube 60, and the dye circulation tube 54A is fitted in the groove 71 of the lens holding frame 70. The tip of the dye circulation tube 54 </ b> A is inserted into the holding hole 63.

  In the form shown in FIG. 21, the dye distribution tube 54A is a marking mechanism. Accordingly, when the dye is supplied to the dye distribution tube 54A by the dye supplier 6h, the dye that has flowed from the base end to the tip end of the dye distribution tube 54A is discharged from the front end opening of the dye distribution tube 54A, and dyeing of the discharged dye is performed. A mark is formed on the biological tissue of the lumen wall.

  The form shown in FIG. 21 is that the high frequency electrode is not inserted into the tube 52 and the second tube 60, the dye circulation tube 54A is inserted into the tube 52 and the second tube 60 instead of the high frequency electrode, Except for flowing through the dye distribution tube 54A, the configuration is the same as that shown in FIG.

[Usage procedure]
The procedure for using the diagnostic system 1A is the same as the procedure for using the diagnostic system 1 except that the biological tissue on the lumen wall is formed with a dye to stain the biological tissue on the lumen wall.

  When the mark is formed on the living tissue on the lumen wall, the dye is injected into the dye distribution tube 54A by the dye supplier 6h. Specifically, when the dye supply unit 6h is a manual syringe, the dye is injected into the dye circulation tube 54A by the dye supply unit 6h when the operator pushes the piston of the manual syringe. On the other hand, when the dye supplier 6h is operated by an actuator, the operator operates the input device 8 so that the computer 6e drives the dye supplier 6h, and the dye supplier 6h injects the dye into the dye circulation tube 54A. Is done.

  In the case of the form shown in FIGS. 14 to 17, when the dye is sent to the tip opening of the small diameter passage 52b, the dye is discharged from the tip opening of the small diameter passage 52b, and the discharged dye is applied to the living tissue on the lumen wall. By adhering, the biological tissue of the lumen wall is stained. In the case of the form shown in FIGS. 18 to 21, when the dye is sent to the tip opening of the dye distribution tube 54A, the dye is discharged from the tip opening of the dye distribution tube 54A, and the discharged dye is applied to the living tissue on the lumen wall. By adhering, the biological tissue of the lumen wall is stained. When the tip opening of the small-diameter hole 52b and the tip opening of the dye circulation tube 54A are blocked by the absorbent 80, the absorbent 80 absorbs the absorbent 80 when the absorbent 80 that has absorbed the dye is applied to the lumen wall. The dye adheres to the living tissue on the lumen wall, thereby staining the living tissue on the lumen wall.

〔effect〕
According to the above embodiment, the following effects can be obtained.
(1) In the case shown in FIGS. 14, 15 and 17, the distal end opening of the small-diameter hole 52b is formed in the distal end surface 52c of the tube 52. In the case shown in FIG. 16, the small-diameter hole 52b Since the distal end opening is formed on the peripheral surface near the distal end of the tube 52, a mark formed by dye staining can be formed on the lumen wall. Also in the case of the form shown in FIGS. 18-21, the mark by dyeing | staining of dye can be formed in a lumen wall. The measurement location and other locations can be identified by the mark.

(2) Without pulling out the probe 5 from the forceps channel 2g, a mark by dye staining can be formed at the measurement location, and the position of the mark can be the same as or close to the measurement location.

(3) In the case of the form shown in FIGS. 14 to 17, the tube 52 is a multi-lumen tube, and a hard member does not protrude from the distal end opening of the small diameter passage 52b, so that the lumen wall is not damaged.
In the case of the form shown in FIGS. 18 to 21, if the tip of the dye circulation tube 54A is aligned with or pulled into the tip surface 52c of the tube 52 (or the tip surface of the second tube 60), the tip of the dye circulation tube 54A Does not damage the lumen wall.
In the case of the form shown in FIGS. 18-21, even if the tip of the dye distribution tube 54A protrudes from the tip surface of the tube 52 or the second tube 60, the dye distribution tube 54A is flexible. There is no risk of damaging the lumen wall by the tip of the tube.

(4) Since the distal end portion of the optical fiber 57 is accommodated in the tube 52 or the second tube 60 and the optical system 58 has a condensing action or a collimating action, the distal end surface of the optical fiber 57 is used as a living tissue on the lumen wall. There is no need to hit it. Therefore, the lumen wall is not damaged by the optical fiber 57.

(5) Since the biological tissue is marked on the lumen wall by staining, the lumen wall is not damaged.

DESCRIPTION OF SYMBOLS 1, 1A Diagnostic system 5 Probe 6b Light source for excitation light 6c Spectrometer 6d High-frequency current source 52 Tip tube 52a Large-diameter hole 52b Small-diameter hole 54 High-frequency cable 54A Dye distribution tube 55 High-frequency electrode 57 Optical fiber 58 Optical system 58a Plane reflecting surface 58b Lens 58c Curved reflecting surface 59 Inner tube 60 Second tip tube 61 Antifouling cover 63 Holding hole

Claims (27)

In the probe that is provided in a linear shape and projects the excitation light from the linear tip to the living tissue, and receives the emitted light generated from the living tissue due to the excitation light at the linear tip,
A probe provided with a marking mechanism provided at a tip of the probe and forming a mark on the living tissue. Tubes,
One or more optical fibers inserted into the tube;
The excitation light provided at the distal end portion of the tube and projected by the distal end surface of the optical fiber is projected onto the biological tissue outside the tube, and the emitted light generated from the biological tissue is projected onto the distal end of the optical fiber. The probe according to claim 1, further comprising: an optical system that projects onto a surface. The tube is a multi-lumen tube having a first hole and a second hole penetrating in the axial direction of the tube,
The marking mechanism is a high-frequency electrode that is electrocauterized by a high-frequency current to form a mark due to a mark on the living tissue,
The optical fiber is inserted into the first hole and held in the first hole;
The optical system is held in the first hole at the tip of the optical fiber;
The probe according to claim 2, wherein the high-frequency electrode is inserted into the second hole path at a distal end portion of the tube. The tube is a multi-lumen tube having a first hole that penetrates in the axial direction of the tube, and a second hole that penetrates from a proximal end surface of the tube to a peripheral surface near the tip of the tube,
The marking mechanism is a high-frequency electrode that is electrocauterized by a high-frequency current to form a mark due to a mark on the living tissue,
The optical fiber is inserted into the first hole and held in the first hole;
The optical system is held in the first hole at the tip of the optical fiber;
The probe according to claim 2, wherein the high-frequency electrode is inserted into the second hole path at a distal end portion of the tube. An inner tube,
The tube is a multi-lumen tube having a first hole and a second hole penetrating in the axial direction of the tube,
The marking mechanism is a high-frequency electrode that is electrocauterized by a high-frequency current to form a mark due to a mark on the living tissue,
The inner tube is inserted into the first hole;
The optical fiber is inserted into the inner tube and held in the inner tube;
The optical system is held in the inner tube at the tip of the optical fiber;
The probe according to claim 2, wherein the high-frequency electrode is inserted into the second hole path at a distal end portion of the tube.   The probe according to any one of claims 3 to 5, wherein the high-frequency electrode protrudes from an opening of the second hole path at a distal end portion of the tube.   The high-frequency cable, which is inserted into the second hole from the opening of the second hole on the proximal end surface of the tube, is connected to the high-frequency electrode, and supplies a high-frequency current to the high-frequency electrode. Item 7. The probe according to any one of Items 3 to 6. An inner tube,
The tube is a single lumen tube having a hole that penetrates in the axial direction of the tube,
The marking mechanism is a high-frequency electrode that is electrocauterized by a high-frequency current to form a mark due to a mark on the living tissue,
The inner tube is inserted into the hole,
The optical fiber is inserted into the inner tube and held in the inner tube;
The optical system is held in the inner tube at the tip of the optical fiber;
The probe according to claim 2, wherein the high-frequency electrode is inserted into the hole at a distal end portion of the tube.   The probe according to claim 8, wherein the high-frequency electrode protrudes from an opening of the hole at a distal end portion of the tube. The tube is a single lumen tube having a hole that penetrates in the axial direction of the tube,
The marking mechanism is a high-frequency electrode that is electrocauterized by a high-frequency current to form a mark due to a mark on the living tissue,
The optical fiber is inserted into the hole and held in the hole;
The optical system is held in the hole at the tip of the optical fiber;
The probe according to claim 2, wherein the high-frequency electrode is inserted into the hole at a distal end portion of the tube. A ring-shaped antifouling cover is provided so as to protrude inward from the inner peripheral surface of the tip opening of the tube,
A holding hole penetrates the antifouling cover,
The probe according to claim 10, wherein a tip portion of the high-frequency electrode is fitted and held in the holding hole.   The probe according to claim 11, wherein a tip of the high-frequency electrode protrudes from the holding hole.   The high-frequency cable that is inserted into the hole from the opening of the hole on the proximal end surface of the tube, is connected to the high-frequency electrode, and supplies a high-frequency current to the high-frequency electrode. The probe according to any one of the above. The tube is a multi-lumen tube having a first hole that penetrates in the axial direction of the tube, and a second hole that penetrates in the axial direction of the tube and circulates the dye,
The optical fiber is inserted into the first hole and held in the first hole;
The optical system is held in the first hole at the tip of the optical fiber;
The marking mechanism discharges the dye circulated through the second hole path from a front end opening of the second hole path, and forms a mark by staining the dye on the living tissue. 2. The probe according to 2. The tube has a first hole that penetrates in the axial direction of the tube, and a second hole that penetrates from the proximal end surface of the tube to the peripheral surface near the distal end of the tube and distributes the dye. A lumen tube,
The optical fiber is inserted into the first hole and held in the first hole;
The optical system is held in the first hole at the tip of the optical fiber;
The marking mechanism discharges the dye circulated through the second hole path from a front end opening of the second hole path, and forms a mark by staining the dye on the living tissue. 2. The probe according to 2. An inner tube,
The tube is a multi-lumen tube having a first hole that penetrates in the axial direction of the tube, and a second hole that penetrates in the axial direction of the tube and circulates the dye,
The inner tube is inserted into the first hole;
The optical fiber is inserted into the inner tube and held in the inner tube;
The optical system is held in the inner tube at the tip of the optical fiber;
The marking mechanism discharges the dye circulated through the second hole path from a front end opening of the second hole path, and forms a mark by staining the dye on the living tissue. 2. The probe according to 2.   17. The marking mechanism according to claim 14, wherein the marking mechanism includes an absorbent material that closes a tip opening of the second hole and absorbs the dye discharged from the tip opening of the second hole. The probe according to any one of the above. An inner tube,
The tube is a multi-lumen tube having a first hole and a second hole penetrating in the axial direction of the tube,
The inner tube is inserted into the first hole;
The optical fiber is inserted into the inner tube and held in the inner tube;
The optical system is held in the inner tube at the tip of the optical fiber;
The marking mechanism is inserted into the second hole path, and has a dye distribution tube for distributing the dye,
The marking mechanism discharges the dye distributed by the dye distribution tube from a front end opening of the dye distribution tube to form a mark on the living tissue by staining the dye. The probe as described. An inner tube,
The tube is a single lumen tube having a hole that penetrates in the axial direction of the tube,
The inner tube is inserted into the hole,
The optical fiber is inserted into the inner tube and held in the inner tube;
The optical system is held in the inner tube at the tip of the optical fiber;
The marking mechanism is inserted into the hole and has a dye distribution tube through which the dye flows;
The marking mechanism discharges the dye distributed by the dye distribution tube from a front end opening of the dye distribution tube to form a mark on the living tissue by staining the dye. The probe as described. The tube is a single lumen tube having a hole that penetrates in the axial direction of the tube,
The optical fiber is inserted into the hole and held in the hole;
The optical system is held in the hole at the tip of the optical fiber;
The marking mechanism is inserted into the hole and has a dye distribution tube through which the dye flows;
The marking mechanism discharges the dye distributed by the dye distribution tube from a front end opening of the dye distribution tube to form a mark on the living tissue by staining the dye. The probe as described. A ring-shaped antifouling cover is provided so as to protrude inward from the inner peripheral surface of the tip opening of the tube,
A holding hole penetrates the antifouling cover,
The probe according to claim 20, wherein a tip end portion of the dye circulation tube is fitted and held in the holding hole.   The said marking mechanism has an absorber which obstruct | occludes the front-end | tip opening of the said dye distribution tube, and absorbs the said dye discharged from the front-end | tip opening of the said dye distribution tube. The probe according to item.   The probe according to any one of claims 2 to 22, wherein the optical system includes a lens.   The probe according to any one of claims 2 to 22, wherein the optical system has a reflecting surface. The probe according to claim 7 or 13,
An excitation light source for supplying excitation light to the proximal end of the optical fiber;
A spectrometer that is incident on the tip of the optical fiber, guides the optical fiber, and measures the intensity of the emitted light emitted from the base end of the optical fiber for each wavelength;
A diagnostic system comprising: a high-frequency current source connected to the high-frequency cable and supplying a high-frequency current to the high-frequency electrode via the high-frequency cable. A probe according to any one of claims 14 to 18,
An excitation light source for supplying excitation light to the proximal end of the optical fiber;
A spectrometer that is incident on the tip of the optical fiber, guides the optical fiber, and measures the intensity of the emitted light emitted from the base end of the optical fiber for each wavelength;
A dye distribution tube connected to the proximal end opening of the second hole;
A diagnostic system comprising: a dye supplier connected to the dye distribution tube and supplying the dye to the dye distribution tube. A probe according to any one of claims 19 to 22,
An excitation light source for supplying excitation light to the proximal end of the optical fiber;
A spectrometer that is incident on the tip of the optical fiber, guides the optical fiber, and measures the intensity of the emitted light emitted from the base end of the optical fiber for each wavelength;
A diagnostic system comprising: a dye supplier connected to the dye distribution tube and supplying the dye to the dye distribution tube.

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