JP2012189465A - Autoanalyzer - Google Patents

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JP2012189465A
JP2012189465A JP2011053691A JP2011053691A JP2012189465A JP 2012189465 A JP2012189465 A JP 2012189465A JP 2011053691 A JP2011053691 A JP 2011053691A JP 2011053691 A JP2011053691 A JP 2011053691A JP 2012189465 A JP2012189465 A JP 2012189465A
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reagent
lid
reagent container
opening
shutter
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JP5452526B2 (en
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Eiichiro Takada
英一郎 高田
Hiroshi Watanabe
洋 渡辺
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Hitachi High Tech Corp
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Hitachi High Technologies Corp
Hitachi High Tech Corp
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Abstract

PROBLEM TO BE SOLVED: To provide an autoanalyzer including a reagent storing part for storing a reagent container with an automatically openable/closable lid on an opening of the reagent container, that protects a hand of an operator from being sandwiched upon closing the lid so as to prevent a trauma from being generated in even such a case.SOLUTION: An autoanalyzer including a reagent storing part for storing a reagent container is characterized in that a lid for closing an opening is moved by driven force such as a motor in an opening direction, and by a spring in a closing direction.

Description

本発明は、血液,尿などの生体サンプルに含まれる各種の成分を定性・定量分析する自動分析装置に係り、特に試薬容器の搬送・架設を自動で行うことができる自動分析装置に関する。   The present invention relates to an automatic analyzer that qualitatively and quantitatively analyzes various components contained in a biological sample such as blood and urine, and more particularly to an automatic analyzer that can automatically carry and mount a reagent container.

自動分析の分野では、複数の反応ラインをランダムに使用するランダムアクセス方式の自動分析装置が開発され、分析の処理能力が飛躍的に向上した。それにともない試薬消費のスピードも速くなり、試薬容器切り替え作業の機会が増えてきた。特許文献1では、試薬登録,試薬交換等の作業によるオペレータの負担を軽減すると共に、分析中の試薬不足を発生させず、分析中断を最小化するため、自動で試薬交換を行うことができる試薬搬入搬出機構を有する自動分析装置が示されている。   In the field of automatic analysis, a random access type automatic analyzer that uses a plurality of reaction lines at random has been developed, and the processing capacity of analysis has been dramatically improved. As a result, the speed of reagent consumption has increased, and the opportunities for reagent container switching work have increased. In Patent Document 1, a reagent that can be automatically replaced in order to reduce the burden on the operator due to operations such as reagent registration and reagent replacement, and to minimize analysis interruption without causing a shortage of reagents during analysis. An automatic analyzer having a loading / unloading mechanism is shown.

特開2005−037171号公報JP 2005-037171 A

特許文献1に示される自動分析装置では、試薬を収容した試薬容器を装置内に引き込む試薬投入機構がある。特許文献1には説明は無いが、試薬投入機構が試薬を引き込む位置には試薬投入機構が試薬を引き込むタイミングに合わせて開閉するシャッタ(蓋)機構があった方が、装置内に埃が混入したりするのを防ぐことができ、好ましい。このようなシャッタ機構は、オペレータが試薬を設置する位置の近傍に存在するため、装置の機構の中でオペレータが最も頻繁に接触する可能性があるため、シャッタが閉じる際にオペレータが手を挟む可能性がある。   The automatic analyzer disclosed in Patent Document 1 has a reagent charging mechanism that draws a reagent container containing a reagent into the apparatus. Although there is no description in Patent Document 1, dust is mixed in the apparatus when there is a shutter (lid) mechanism that opens and closes in accordance with the timing when the reagent loading mechanism pulls in the reagent at the position where the reagent loading mechanism pulls in the reagent. Can be prevented, which is preferable. Since such a shutter mechanism exists in the vicinity of the position where the operator installs the reagent, there is a possibility that the operator will make the most frequent contact among the mechanisms of the apparatus. there is a possibility.

本発明の目的は、シャッタが閉まるときにシャッタと壁の間に何かが挟まったとしてもシャッタの駆動系が異常動作を起こすことなく動作し、また挟まった物に対して与える負荷が最小限となることで、故障が少なく安全性の高い機構を備えた自動分析装置を提供することにある。   It is an object of the present invention to operate the shutter drive system without causing an abnormal operation even if something is caught between the shutter and the wall when the shutter is closed, and to minimize the load applied to the caught object. Therefore, an object of the present invention is to provide an automatic analyzer equipped with a mechanism with few failures and high safety.

上記目的を達成するための構成は以下の通りである。   The configuration for achieving the above object is as follows.

試薬容器を収容する試薬容器収容部と、該試薬容器収容部に試薬容器を出し入れするための開口部と、を有する試薬容器収容機構を備えた自動分析装置において、前記開口部は、該開口部を閉じるための蓋部と、該蓋部を開く方向に力を加える駆動機構と、該駆動機構が前記蓋部を開く方向に動かすのとは逆方向に力を加えるバネ機構と、を備え、前記駆動機構は、前記蓋部と連動する係合部に力を加える力伝達機構を備え、かつ該力伝達機構が前記係合部に接触していない場合は、前記バネ機構が加える力により、前記蓋部を閉じる方向に力がかかることを特徴とする自動分析装置。   In an automatic analyzer having a reagent container housing mechanism having a reagent container housing portion for housing a reagent container and an opening portion for inserting / removing the reagent container into / from the reagent container housing portion, the opening portion includes the opening portion. A lid for closing the lid, a drive mechanism for applying a force in the direction of opening the lid, and a spring mechanism for applying a force in the opposite direction to the drive mechanism moving in the direction of opening the lid, The drive mechanism includes a force transmission mechanism that applies a force to an engagement portion that is interlocked with the lid portion, and when the force transmission mechanism is not in contact with the engagement portion, the force that the spring mechanism applies, An automatic analyzer characterized in that a force is applied in a direction to close the lid.

好ましい実施態様としては、以下のようなものがある。   Preferred embodiments include the following.

複数の反応容器に試料と試薬を分注して反応させ、反応した液体を測定する自動分析装置において、試薬を収容した試薬容器を装置内に引き込む試薬投入機構を備え、試薬投入機構が試薬を引き込むタイミングに合わせて開閉するシャッタ機構を有し、シャッタ機構は、モータ,バネとリニアガイド2本を有し、モータの力によってシャッタが開き、バネの力によってシャッタが閉じることを特徴とする自動分析装置。   An automatic analyzer that dispenses and reacts samples and reagents in a plurality of reaction containers and measures the reacted liquid, and is equipped with a reagent loading mechanism that draws the reagent container containing the reagent into the device. It has a shutter mechanism that opens and closes in accordance with the pull-in timing. The shutter mechanism has a motor, a spring, and two linear guides. The shutter is opened by the force of the motor, and the shutter is closed by the force of the spring. Analysis equipment.

蓋は、直線的に移動する必要は無く、1点を中心に回転動作する板状部材を含み、板状部材の一部に開口部が設けられているようなものであっても良い。   The lid does not need to move linearly, and may include a plate-like member that rotates around one point, and an opening is provided in a part of the plate-like member.

また、引き戸のような鉛直方向に並行な軸の周りに回転する板状部材を含む蓋とすることもできる。   Moreover, it can also be set as the lid | cover containing the plate-shaped member rotated around the axis | shaft parallel to a perpendicular direction like a sliding door.

シャッタが閉まるときにシャッタと壁の間に何かが挟まったとしてもシャッタの駆動系が異常動作を起こすことなく動作し、また挟まった物に対して与える負荷が最小限となるため、故障が少なく安全性の高い機構となる。   Even if something is caught between the shutter and the wall when the shutter is closed, the shutter drive system operates without causing abnormal operation, and the load applied to the caught object is minimized. The mechanism is small and highly safe.

本発明の自動分析装置の平面図。The top view of the automatic analyzer of this invention. シャッタ機構の構成の詳細図A。Detailed view A of the configuration of the shutter mechanism. シャッタ機構の構成の詳細図B。Detailed view B of the configuration of the shutter mechanism. シャッタ機構の構成の詳細図C。Detailed view C of the configuration of the shutter mechanism. シャッタ機構の構成の詳細図D。Detailed view D of the configuration of the shutter mechanism.

以下、図面を用いて本発明の実施の形態を説明する。   Hereinafter, embodiments of the present invention will be described with reference to the drawings.

図1は、本発明が適用された自動分析装置の一実施例の概略構成図である。以下、試薬容器12の搬送手順を詳細に説明する。試薬投入機構24に試薬容器12が置かれると、シャッタ機構36が開き、試薬投入機構24により試薬容器12は補充用試薬保管庫20上に移動する。補充用試薬保管庫20上に移動した試薬容器12は、試薬情報読取り機構21により、試薬容器12に添付されたRFIDタグを読み取られた後、補充用試薬保管庫20に保管される。試薬または試薬容器12に不備があった場合、試薬排出機構25から試薬容器12は排出される。試薬容器12はオペレータが取り出し易い向きに回転して排出される。試薬保管庫A28もしくはB29へ試薬を補充するように、制御部から合図があると、試薬容器12は試薬キャップ開栓機構23の下まで回転して移動し、試薬キャップ開栓機構23により試薬容器12の試薬キャップが開けられる。このとき、試薬キャップは試薬キャップ廃棄箱34に廃棄される。さらに試薬容器12は、試薬受け渡し機構22のポジションまで回転して移動し、試薬回転機構32まで押し出される。   FIG. 1 is a schematic configuration diagram of an embodiment of an automatic analyzer to which the present invention is applied. Hereinafter, the procedure for transporting the reagent container 12 will be described in detail. When the reagent container 12 is placed in the reagent loading mechanism 24, the shutter mechanism 36 is opened, and the reagent container 12 is moved onto the replenishing reagent storage 20 by the reagent loading mechanism 24. The reagent container 12 moved onto the replenishment reagent storage 20 is stored in the replenishment reagent storage 20 after the RFID tag attached to the reagent container 12 is read by the reagent information reading mechanism 21. If there is a defect in the reagent or reagent container 12, the reagent container 12 is discharged from the reagent discharge mechanism 25. The reagent container 12 is rotated and discharged in a direction that is easy for the operator to take out. When there is a signal from the control unit so as to replenish the reagent in the reagent storage A28 or B29, the reagent container 12 rotates and moves under the reagent cap opening mechanism 23, and the reagent container is opened by the reagent cap opening mechanism 23. Twelve reagent caps are opened. At this time, the reagent cap is discarded in the reagent cap disposal box 34. Furthermore, the reagent container 12 rotates and moves to the position of the reagent delivery mechanism 22 and is pushed out to the reagent rotation mechanism 32.

試薬回転機構32では、試薬容器12を受け取ったことをセンサで検知した後、回転する。試薬搬送機構27は、試薬回転機構32上に試薬容器設置機構35を移動させた後、試薬回転機構32上の試薬容器12を試薬容器設置機構35で保持し、試薬投入口A30もしくはB31の上まで試薬容器12を搬送する。そこから試薬容器設置機構35をZ方向(自動分析装置の上下方向)に移動させ、試薬容器12を試薬保管庫A28もしくはB29内に架設する。架設された試薬容器12から試薬を反応機構33に並べられている複数の反応容器に分注し、そこで試料と試薬を反応させ、測定する。空になった試薬容器12は、試薬保管庫A28もしくはB29から試薬容器設置機構35で吊り上げられて取り出され、試薬排出収納機構26まで搬送される。   The reagent rotating mechanism 32 rotates after detecting that the reagent container 12 has been received by the sensor. The reagent transport mechanism 27 moves the reagent container installation mechanism 35 onto the reagent rotation mechanism 32, and then holds the reagent container 12 on the reagent rotation mechanism 32 with the reagent container installation mechanism 35, and moves the reagent container 12 over the reagent inlet A30 or B31. Until the reagent container 12 is conveyed. From there, the reagent container installation mechanism 35 is moved in the Z direction (vertical direction of the automatic analyzer), and the reagent container 12 is installed in the reagent storage A28 or B29. The reagent is dispensed from the constructed reagent container 12 into a plurality of reaction containers arranged in the reaction mechanism 33, where the sample and the reagent are reacted and measured. The emptied reagent container 12 is lifted and removed from the reagent storage A28 or B29 by the reagent container installation mechanism 35, and is transported to the reagent discharge and storage mechanism 26.

図2〜図5はシャッタ機構36の構成の詳細図である。シャッタ機構36は、リニアガイドA37,リニアガイドB38の2つのリニアガイド、モータ39,プーリ40,ベルト41、それらをつなぐ部材、シャッタ42,バネ43を備えている。モータ39及びプーリ40により、ベルト41が2つのプーリ40間を往復運動する。それに伴いベルト駆動部材44,バネ駆動部材45がそれぞれリニアガイドA37,リニアガイドB38に沿って動くように構成されている。シャッタ42はバネ駆動部材45と共にリニアガイドB38に沿って動く。図2はシャッタ42が閉じた状態、図3はシャッタ42が開いた状態、図4はシャッタ42とベース46の間に例として試薬容器12が挟まった瞬間の状態、図5は図4の後にモータ39は回転を続け、ベルト駆動部材44が、シャッタ42が閉じた状態(図2)と同じ位置まで移動した状態を示している。   2 to 5 are detailed views of the configuration of the shutter mechanism 36. The shutter mechanism 36 includes two linear guides, a linear guide A37 and a linear guide B38, a motor 39, a pulley 40, a belt 41, a member connecting them, a shutter 42, and a spring 43. The belt 41 reciprocates between the two pulleys 40 by the motor 39 and the pulley 40. Accordingly, the belt driving member 44 and the spring driving member 45 are configured to move along the linear guide A37 and the linear guide B38, respectively. The shutter 42 moves along the linear guide B38 together with the spring drive member 45. 2 is a state in which the shutter 42 is closed, FIG. 3 is a state in which the shutter 42 is open, FIG. 4 is a state in which the reagent container 12 is sandwiched between the shutter 42 and the base 46, and FIG. The motor 39 continues to rotate, and the belt drive member 44 has moved to the same position as the shutter 42 closed (FIG. 2).

まず、シャッタ42が閉じた状態(図2)からシャッタ42が開いた状態(図3)への動作を説明する。モータ39の回転運動によりベルト41に取り付いているベルト駆動部材44がリニアガイドA37に沿って図示X方向へ移動する。ベルト駆動部材44はバネ駆動部材45と接触しているため、ベルト駆動部材44に伴って、バネ駆動部材45及びそれに取り付いているシャッタ42がリニアガイドB38に沿って図示X方向へ移動する。これによりシャッタ42は開いた状態(図3)となる。   First, the operation from the state where the shutter 42 is closed (FIG. 2) to the state where the shutter 42 is opened (FIG. 3) will be described. The belt drive member 44 attached to the belt 41 is moved in the X direction in the drawing along the linear guide A37 by the rotational movement of the motor 39. Since the belt driving member 44 is in contact with the spring driving member 45, the spring driving member 45 and the shutter 42 attached thereto move in the X direction in the drawing along the linear guide B38 along with the belt driving member 44. As a result, the shutter 42 is opened (FIG. 3).

次に、シャッタ42が開いた状態(図3)からシャッタ42が閉じた状態(図2)への動作を説明する。モータ39の回転運動によりベルト41に取り付いているベルト駆動部材44がリニアガイドA37に沿って図示Y方向へ移動する。ここで、バネ駆動部材45にはバネ43が取り付いており、図示Y方向にバネ43の力が働いているため、ベルト駆動部材44の移動に伴ってバネ駆動部材45及びシャッタ42は図示Y方向へ移動する。このとき、バネ駆動部材45はベルト駆動部材44と共に移動するが、これはバネ43の力のためであり、シャッタ42が開く時のようにベルト駆動部材44がバネ駆動部材45を押すことでシャッタが移動するわけではない。これによりシャッタ42は閉じた状態(図2)となる。   Next, the operation from the state where the shutter 42 is opened (FIG. 3) to the state where the shutter 42 is closed (FIG. 2) will be described. The belt drive member 44 attached to the belt 41 is moved in the Y direction in the drawing along the linear guide A37 by the rotational movement of the motor 39. Here, since the spring 43 is attached to the spring driving member 45 and the force of the spring 43 is acting in the Y direction in the drawing, the spring driving member 45 and the shutter 42 are moved in the Y direction in the drawing as the belt driving member 44 moves. Move to. At this time, the spring drive member 45 moves together with the belt drive member 44, which is due to the force of the spring 43, and the shutter is driven by the belt drive member 44 pushing the spring drive member 45 as when the shutter 42 is opened. Does not move. As a result, the shutter 42 is closed (FIG. 2).

シャッタ42が閉まるときに試薬容器12が挟まった場合のシャッタ42の動作を以下に説明する。シャッタ42が開いた状態(図3)からシャッタ42が閉じた状態(図2)への動作の途中で、シャッタ42とベースの間に試薬容器12が挟まると、シャッタ42は図示Y方向への移動を停止する。これが図4の状態である。この後モータ39は回転を続け、ベルト駆動部材44はシャッタ42が閉じた状態のときと同じ位置まで移動する。これが図5の状態である。バネ駆動部材45が試薬容器12に対して接触するため、試薬容器12にはバネ43の力による負荷がかかるが、モータ39からの力は受けない。試薬容器12が取り除かれると、シャッタ42はバネ43の力により自動で閉まり、シャッタ42は閉じた状態(図2)となる。   The operation of the shutter 42 when the reagent container 12 is sandwiched when the shutter 42 is closed will be described below. If the reagent container 12 is sandwiched between the shutter 42 and the base during the operation from the state in which the shutter 42 is open (FIG. 3) to the state in which the shutter 42 is closed (FIG. 2), the shutter 42 moves in the Y direction shown in the figure. Stop moving. This is the state of FIG. Thereafter, the motor 39 continues to rotate, and the belt driving member 44 moves to the same position as when the shutter 42 is closed. This is the state of FIG. Since the spring drive member 45 comes into contact with the reagent container 12, the reagent container 12 is loaded by the force of the spring 43, but is not subjected to the force from the motor 39. When the reagent container 12 is removed, the shutter 42 is automatically closed by the force of the spring 43, and the shutter 42 is closed (FIG. 2).

10 分析ユニット
11 バッファユニット
12 試薬容器
20 補充用試薬保管庫
21 試薬情報読取り機構
22 試薬受け渡し機構
23 試薬キャップ開栓機構
24 試薬投入機構
25 試薬排出機構
26 試薬排出収納機構
27 試薬搬送機構
28 試薬保管庫A
29 試薬保管庫B
30 試薬投入口A
31 試薬投入口B
32 試薬回転機構
33 反応機構
34 試薬キャップ廃棄箱
35 試薬容器設置機構
36 シャッタ機構
37 リニアガイドA
38 リニアガイドB
39 モータ
40 プーリ
41 ベルト
42 シャッタ
43 バネ
44 ベルト駆動部材
45 バネ駆動部材
46 ベース
DESCRIPTION OF SYMBOLS 10 Analysis unit 11 Buffer unit 12 Reagent container 20 Replenishment reagent storage 21 Reagent information reading mechanism 22 Reagent delivery mechanism 23 Reagent cap opening mechanism 24 Reagent insertion mechanism 25 Reagent discharge mechanism 26 Reagent discharge storage mechanism 27 Reagent transport mechanism 28 Reagent storage Storage A
29 Reagent Storage B
30 Reagent inlet A
31 Reagent inlet B
32 Reagent rotation mechanism 33 Reaction mechanism 34 Reagent cap waste box 35 Reagent container installation mechanism 36 Shutter mechanism 37 Linear guide A
38 Linear guide B
39 Motor 40 Pulley 41 Belt 42 Shutter 43 Spring 44 Belt drive member 45 Spring drive member 46 Base

Claims (3)

試薬容器を収容する試薬容器収容部と、該試薬容器収容部に試薬容器を出し入れするための開口部と、を有する試薬容器収容機構を備えた自動分析装置において、
前記開口部は、該開口部を閉じるための蓋部と、該蓋部を開く方向に力を加える駆動機構と、該駆動機構が前記蓋部を開く方向に動かすのとは逆方向に力を加えるバネ機構と、を備え、
前記駆動機構は、前記蓋部と連動する係合部に力を加える力伝達機構を備え、かつ該力伝達機構が前記係合部に接触していない場合は、前記バネ機構が加える力により、前記蓋部を閉じる方向に力がかかることを特徴とする自動分析装置。
In an automatic analyzer equipped with a reagent container housing mechanism having a reagent container housing portion for housing a reagent container, and an opening for taking the reagent container into and out of the reagent container housing portion,
The opening includes a lid for closing the opening, a driving mechanism that applies a force in the direction of opening the lid, and a force in a direction opposite to the direction in which the driving mechanism moves in the direction of opening the lid. A spring mechanism to add,
The drive mechanism includes a force transmission mechanism that applies a force to an engagement portion that is interlocked with the lid portion, and when the force transmission mechanism is not in contact with the engagement portion, the force that the spring mechanism applies, An automatic analyzer characterized in that a force is applied in a direction to close the lid.
請求項1記載の自動分析装置において、
前記蓋部は、該蓋部を開く方向に直線的に移動する板状部材を含み、前記係合部は、該板状部材に設けられた突起部であり、前記力伝達機構は、ループ状のベルトであり、該ベルトは前記駆動部の回転動作により、前記板状部材が移動する直線と並行に移動し、該ベルトの一部に前記突起部と係合する係合部を備えたことを特徴とする自動分析装置。
The automatic analyzer according to claim 1, wherein
The lid portion includes a plate-like member that linearly moves in a direction of opening the lid portion, the engagement portion is a protrusion provided on the plate-like member, and the force transmission mechanism is in a loop shape The belt is provided with an engaging portion that moves in parallel with the straight line along which the plate-like member moves by the rotational operation of the driving portion, and engages with the protruding portion at a part of the belt. Automatic analyzer characterized by
請求項1記載の自動分析装置において、
前記蓋部は、1点を中心に回転移動する板状部材を含み、該板状部材の少なくとも一部に開口部を備え、前記係合部は、該板状部材に設けられた突起部であり、前記力伝達機構は、前記駆動部の回転動作により、前記板状部材の回転方向と同心円の円周上を移動する、前記突起部と係合する係合部を備えたことを特徴とする自動分析装置。
The automatic analyzer according to claim 1, wherein
The lid portion includes a plate-like member that rotates around one point, and includes an opening in at least a part of the plate-like member, and the engaging portion is a protrusion provided on the plate-like member. And the force transmission mechanism includes an engaging portion that engages with the protruding portion that moves on a circumference concentric with the rotation direction of the plate-like member by the rotation operation of the driving portion. Automatic analyzer to do.
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Publication number Priority date Publication date Assignee Title
JP2018136225A (en) * 2017-02-22 2018-08-30 株式会社日立ハイテクノロジーズ Automatic analyzer
CN114113618A (en) * 2022-01-26 2022-03-01 山东康华生物医疗科技股份有限公司 Door stop mechanism for fluorescence immunoassay quantitative analyzer core

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JPS6125237B2 (en) * 1979-09-06 1986-06-14 Matsushita Electric Ind Co Ltd
JPH0436658A (en) * 1990-05-31 1992-02-06 Shimadzu Corp Reagent dispenser for automatic analysis apparatus
JPH07128340A (en) * 1993-11-08 1995-05-19 Fuji Photo Film Co Ltd Storing unit for dry analytic film
JP2008020361A (en) * 2006-07-13 2008-01-31 Olympus Corp Autoanayzer
JP2008268033A (en) * 2007-04-20 2008-11-06 Astec Corp:Kk Preparation device of test tube to rack

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JPS6125237B2 (en) * 1979-09-06 1986-06-14 Matsushita Electric Ind Co Ltd
JPH0436658A (en) * 1990-05-31 1992-02-06 Shimadzu Corp Reagent dispenser for automatic analysis apparatus
JPH07128340A (en) * 1993-11-08 1995-05-19 Fuji Photo Film Co Ltd Storing unit for dry analytic film
JP2008020361A (en) * 2006-07-13 2008-01-31 Olympus Corp Autoanayzer
JP2008268033A (en) * 2007-04-20 2008-11-06 Astec Corp:Kk Preparation device of test tube to rack

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018136225A (en) * 2017-02-22 2018-08-30 株式会社日立ハイテクノロジーズ Automatic analyzer
CN114113618A (en) * 2022-01-26 2022-03-01 山东康华生物医疗科技股份有限公司 Door stop mechanism for fluorescence immunoassay quantitative analyzer core
CN114113618B (en) * 2022-01-26 2022-05-17 山东康华生物医疗科技股份有限公司 Door stop mechanism for fluorescence immunoassay quantitative analyzer core

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