JP2012167029A - Anti-residential environment fungus agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an antifungal agent which is useful for growth inhibition or removal of residential environment fungus.SOLUTION: This anti-residential environment fungus agent is obtained by combining following components (A) and (B): (A) one or more kinds of quaternary ammonium salts selected from dialkyldimethyl ammonium salts and alkylbenzyldimethyl ammonium salts, (B) one or more kinds of organic solvents selected from benzyl alcohol, diethylene glycol monobenzyl ether, 2-benzyloxyethanol, 1-(2-butoxy-1-methylethoxy)propan-2-ol, 1-pentanol and 1-phenoxy-2-propanol.

Description

  The present invention relates to an anti-residential fungal agent useful for preventing or removing the growth of a living environmental fungus.

  There are many microorganisms that adhere to clothes, fungi that grow in washing machines, bathrooms, etc. in houses, commercial buildings, hospitals, and the like. Of these, fungi such as ascomycota or incomplete fungi can cause diseases such as mold stains, mold allergy, pulmonary mycosis, and dermatomycosis. Therefore, from the viewpoint of environmental hygiene, a method for effectively controlling such fungi is desired.

  Organic antifungal agents such as imidazole compounds (thiabendazole, etc.), phthalimide compounds (captan, etc.), phenolic compounds (chlorxylenol, etc.), nitrile compounds (chlorotalonyl, etc.), pyridine compounds (sodium pyrithione, etc.), iodo series Compounds (diiodomethyl-p-tolylsulfone) and the like are known (Non-patent Document 1), and natural antifungal agents such as Soso bamboo extract, mustard oil, cinnamon oil, clove oil, hiba oil and other natural essential oils, tetrahydrolinalol and the like Perfume is known (Patent Document 1). However, there are many problems in terms of low solubility in water, skin irritation, substrate damage, and persistence, and it cannot be used in a living environment or the effect is insufficient even if it can be used. It was. Similarly, sodium hypochlorite and the like are known, but there are limitations in handling due to the properties as a chemical substance.

On the other hand, a coating composition comprising an antifungal agent such as 2- (4-thiazolyl) benzimidazole and β-phenoxyethanol exerts an antifungal effect over a long period of time (Patent Document 2), alkylmethylammonium chloride, 2- It has been reported that a fungicide composition containing a specific proportion of phenoxyethanol, ethanol and / or isopropyl alcohol is effective in inhibiting the growth of fungi ( Aspergillus niger , Alternaria genus, Cladosporium genus, Penicillium genus) ( Patent document 3), however, suppresses the growth of cocoon over a long period of time, and does not show bactericidal properties in a short time. In addition, it has been reported that an antibacterial composition containing an antibacterial active solvent such as benzyl alcohol and an antifungal agent such as peracid is useful for reducing the number of bacteria in Chaetomium funicola , which is a food-contaminated mold (Patent Document 4). However, heating is necessary to effectively reduce the number of bacteria, and no effect at room temperature has been shown.

  Since an agent that effectively controls wrinkles that cause problems in a living environment is required to exhibit a sufficient killing effect at room temperature and in a short time, it cannot be said that these effects are sufficient in this environment.

JP-A-4-21606 Japanese Patent Publication 7-100767 Japanese Patent Publication No. 7-80726 JP-T-2004-508291

"The latest antibacterial and antifungal technologies and actual DDS" Shigeharu Ueda, Atsushi Nishino, NTS, 2005

  The present invention relates to providing an antifungal agent useful for inhibiting, preventing or removing the growth of fungus in living environment.

The present inventors examined components that can effectively suppress or inhibit the growth of living environmental fungi such as Cladosporium fungus, Aspergillus fungus, Penicillium fungus, Phoma fungus, Aureobasidium fungus, and the like. Selected from quaternary ammonium salt and benzyl alcohol, diethylene glycol monobenzyl ether, 2-benzyloxyethanol, 1- (2-butoxy-1-methylethoxy) propan-2-ol, 1-pentanol, 1-phenoxy-2-propanol When a specific organic solvent is used in combination, the antibacterial activity is significantly higher than when the quaternary ammonium salt is used alone. For example, when the quaternary ammonium salt is used alone, the antibacterial activity is increased. Even at a concentration that does not fully exhibit the antibacterial properties, it exhibits excellent antibacterial properties and is useful for suppressing, preventing, or removing blackened stains derived from the fungus. It found Rukoto.

That is, the present invention relates to the following 1) to 7).
1) An anti-residential fungus agent comprising a combination of the following components (A) and (B).
(A) One or more quaternary ammonium salts selected from dialkyldimethylammonium salts and alkylbenzyldimethylammonium salts (B) benzyl alcohol, diethylene glycol monobenzyl ether, 2-benzyloxyethanol, 1- (2-butoxy-1 -One or more organic solvents selected from -methylethoxy) propan-2-ol, 1-pentanol and 1-phenoxy-2-propanol 2) Contact within 5 minutes with no heat treatment applied to living environmental fungi And 1) the anti-residential environmental fungus that exerts an effect of reducing the number of bacteria of 1 log or more.
3) The anti-residential environmental fungus according to 1) or 2) above, wherein the quaternary ammonium salt of (A) is one or more selected from octylbenzyldimethylammonium chloride, dodecylbenzyldimethylammonium chloride and didecyldimethylammonium chloride. .
4) The anti-residential environmental fungus according to 1) to 3) above, wherein the organic solvent of (B) is benzyl alcohol.
5) The antifungal agent composition containing the anti-residential environment fungal agent of 1) to 4) above.
6) The composition according to 5) above, wherein the composition contains 5 to 6000 ppm of the component (A) and 5000 ppm or more of the component (B).
7) (A) One or more quaternary ammonium salts selected from dialkyldimethylammonium salts and alkylbenzyldimethylammonium salts are added to (B) benzyl alcohol, diethylene glycol monobenzyl ether, 2-benzyloxyethanol, 1- (2 1-butoxy-1-methylethoxy) propan-2-ol, 1-pentanol and 1-phenoxy-2-propanol are used in combination with one or more organic solvents, wherein Antibacterial enhancement method of quaternary ammonium salt.

  According to the anti-residential fungal agent of the present invention, a hard surface such as a living environment, in particular, a wall such as a kitchen, a bathroom, a toilet, a wash basin, an appliance / equipment such as a washing tub, a packing such as a bathroom door or window, Or, when used for clothing, etc., the fungi on the hard surface and clothing can be sterilized, suppressed, or removed, or the formation and suppression of dark stains derived from the fungi can be easily removed, and attached dark stains can be easily removed. It becomes possible. In addition, according to the present invention, it is possible to express the effect at a normal temperature and in a short time required when used in a living environment.

Dialkyldimethylammonium salt and alkylbenzyldimethylammonium salt, which are quaternary ammonium salts of component (A), are known compounds as antibacterial cationic surfactants. These may be used alone or in combination of two or more.
In the present invention, the dialkyldimethylammonium salt and the alkylbenzyldimethylammonium salt are preferably a dialkyl (C _8-18 ) dimethylammonium salt and an alkyl (C _8-18 ) benzyldimethylammonium salt, respectively.
Here, as an alkyl group, a C8-C18 alkyl group, Preferably a C8-C18 linear alkyl group is mentioned. Specific examples include octyl, decyl, dodecyl (lauryl), tetradecyl (myristyl), hexadecyl (cetyl), heptadecyl, and octadecyl (stearyl), and more preferably octyl, decyl, and dodecyl.
Suitable dialkyldimethylammonium salts include didecyldimethylammonium salts, and alkylbenzyldimethylammonium salts include octylbenzyldimethylammonium salts and dodecylbenzyldimethylammonium salts.

Ammonium salts include salts with halide ions such as F ⁻ , Cl ⁻ , Br ⁻ and I ⁻ , NO ₃ ⁻ , SO ₄ ^2−, etc., and salts with halide ions are preferred and chlorides. More preferred are salts with ions.

  More preferable quaternary ammonium salts include octylbenzyldimethylammonium chloride, dodecylbenzyldimethylammonium chloride, and didecyldimethylammonium chloride.

  The quaternary ammonium salt of the present invention can be produced using a known method, and a commercially available product can also be used. For example, Cotamin D10P (manufactured by Kao Corporation) as a dialkyldimethylammonium salt and Sanizol 08, Sanisole C (manufactured by Kao Corporation), etc. can be purchased and used as an alkylbenzyldimethylammonium salt.

The quaternary ammonium salts generally exhibit antibacterial activity against contact with Penicillium , Aspergillus , Candida, etc., even when used alone for about 24 hours, but the effect is insufficient in a short time. Furthermore, the antibacterial activity varies depending on the type and state of the fungus, and there is a case where no significant decrease in the number of bacteria is observed unless used for a long time or at a high concentration. In addition, depending on the situation of use, there is a possibility of deteriorating the soiled cloth or hard surface, so that a sufficient concentration cannot be blended or a sufficient contact time cannot be obtained.

Component (B) organic solvents include benzyl alcohol, diethylene glycol monobenzyl ether, 2-benzyloxyethanol, 1- (2-butoxy-1-methylethoxy) propan-2-ol, 1-pentanol and 1-phenoxy -2-propanol can be used alone or in admixture of two or more. Such an organic solvent is preferably benzyl alcohol, 2-benzyloxyethanol, 1-pentanol, 1-phenoxy-2-propanol, more preferably benzyl alcohol, 2-benzyloxyethanol, 1-phenoxy. 2-propanol is mentioned, More preferably, benzyl alcohol is mentioned.
In addition, the organic solvent of a component (B) can purchase and use a commercial item. For example, Nippon Emulsifier Co., Ltd. or Nippon Shokubai products can be purchased and used.

As specific combinations of components (A) and (B), component (A) is didecyldimethylammonium salt, octylbenzyldimethylammonium salt or dodecylbenzyldimethylammonium salt, component (B) is benzyl alcohol, 2- Benzyloxyethanol or 1-phenoxy-2-propanol is preferred, and in terms of antibacterial activity against Cladosporium fungus, Penicillium fungus or Aspergillus fungus, component (A) is octylbenzyldimethylammonium salt or dodecylbenzyldimethylammonium. salt is preferably the component (B) is benzyl alcohol, Cladosporium Shokumakin, Alternaria Shokumakin, Ochroconis Shokumakin, Phialophora Shokumakin, Phoma Shokumakin, Aspergillus Shokumakin, Aureobasidium Shokumakin, Exophiala spp black such as fungi In terms of antibacterial activity against fungi, It is preferred that component (A) is octylbenzyldimethylammonium and component (B) is benzyl alcohol.

In the anti-residential fungal agent of the present invention using the combination of the above (A) quaternary ammonium salt and (B) a specific organic solvent, the antibacterial activity against the fungus of the quaternary ammonium salt is significantly improved.
When a quaternary ammonium salt is used alone, excellent antibacterial performance is exhibited even at a concentration and contact time at which antibacterial activity cannot be sufficiently exhibited.
And as for the antibacterial property, a heat treatment is not applied to the fungus, and a decrease in the number of bacteria of 1 log or more is recognized by contact within 5 minutes, and the antibacterial effect is exhibited in a shorter time (Example 1- 4).

  In the present invention, the fact that heat treatment is not added is that heat treatment alone does not affect fungal viability, and a specific example is treatment at a temperature within the normal temperature range of the living environment. More specifically, the treatment is performed at 0 to 45 ° C. It should be noted that the fact that the viability of fungi is not affected means that the number of bacteria does not substantially decrease, and specifically, the number of bacteria does not decrease to ½ or less.

Accordingly, the anti-residential fungus agent of the present invention has an effect of reducing the number of bacteria by 1 log or more, further 2 log or more, further 3 log or more, and further 4 log or more by contact within 5 minutes at room temperature (without heat treatment). Those having antibacterial performance are preferred.
Among living environmental fungi, those exhibiting antibacterial activity against black fungi represented by Cladosporium fungus, Aspergillus fungus, Alternaria fungus, Phoma fungus, Aureobasidium fungus, Exophiala sp Is more preferred.

The anti-residential fungus agent of the present invention is an antifungal agent that sterilizes a living environment fungus and suppresses or prevents its growth, or an antifungal agent for preventing or removing dark stains derived from a living environment fungus in a living environment. Can be used as
Here, “residential fungi” refers to fungi present in buildings such as residences, commercial buildings, research institutes, factories, hospitals, schools, restaurants, bathhouses, fungi attached to clothes, air conditioning equipment, washing tubs , Meaning fungi present in manufacturing equipment, medical equipment, cooking utensils and the like. Ascomycomycetes and imperfect fungal fungi have been detected in washing water, washing tubs, domestic wastewater, bathrooms, domestic bathrooms or public baths, and wastewater sludge (eg, Bokin Bobai, 30 (11) 703-708 (2002); hygiene, 49 (3), p. 161-167 (2005); Mycopathologia, 97, p. 17-23 (1987); Bokin Bobai, 30 (6), p. 369-376 (2002); “Infection caused by fungi is increasing”, p. 139-144, agricultural cooperatives, 2006, etc.).
Therefore, the living environmental fungi to which the composition of the present invention is applied preferably include ascomycota or incomplete fungi, specifically, Exophiala spp, Acremonium spp, Fusarium spp, Scolecobasidium Shokumakin, Chaetomium Shokumakin, Phoma Shokumakin, Phialophora Shokumakin, Cladosporium Shokumakin, Ochroconis Shokumakin, Alternaria Shokumakin, Saccharomyces Shokumakin, Rhodotorula Shokumakin, Aspergillus Shokumakin, Penicillium Shokumakin, Aureobasidium Shokumakin, Candida spp Fungi, Pichia spp, Ramichloridium spp, Capronia spp, Trichoderma spp, Alcaligenes spp, Eurotium spp, Carvularia spp, Cruptococcus spp, Chrysosporium spp, Byssochlamys spp, Botrytis spp, Epicoccum sp Geotricham Shokumakin, Gliocladium Shokumakin, Monascus Shokumakin, Monillia Shokumakin, Mucor Shokumakin, Nigrospora Shokumakin, Oidium Shokumakin, Paecilomyces Shokumakin, Pe stalotia Shokumakin, Rhizopus Shokumakin, Rhizoctonia Shokumakin, Scopulariopsis Shokumakin, Stachybotrys Shokumakin, Symcephalastrum Shokumakin, Trichothesium Shokumakin, Ulocladium spp fungi and Wallemia genus fungi, and the like. Of these, Cladosporium fungus, Alternaria fungus, Ochroconis fungus, Phialophora fungus, Phoma fungus, Aspergillus fungus, Aureobasidium fungus, Exophiala fungus, etc. "Black fungus". Therefore, the composition of the present invention preferably has an excellent antibacterial action against such black fungi, and does not exhibit antibacterial activity unless a quaternary ammonium salt is used at a relatively high concentration. More preferably, those exhibiting at least antibacterial activity against Cladosporium fungi and Aspergillus fungi.

  In the anti-residential fungal agent of the present invention, the mass ratio of the components (A) and (B) is (A) / (B) of 200/1 to 1/40000, more preferably 20/1 to 1/10000, and further 2 / 1 to 1/4000 is preferable.

  The anti-residential fungal agent of the present invention is composed of only other components (A) and (B) or, if necessary, other components, for example, in order to further improve the antibacterial effect and sustain the effect. Along with chelating agents, water-soluble solvents, other surfactants, etc., the above-mentioned various living environments or products and preparations used in living environments (for example, washing and drying machine cleaners, drain outlet cleaners, faucet care agents, baths) Can be used as a material for imparting antibacterial properties to detergents and toilet detergents.

  Here, as the chelating agent, (1) tripolyphosphoric acid, pyrophosphoric acid, orthophosphoric acid, hexametaphosphoric acid and alkali metal salts thereof, (2) ethylenediaminetetraacetic acid, hydroxyiminodiacetic acid, dihydroxyethylglycine, nitrilotriacetic acid, hydroxyethylenediamine Triacetic acid, diethylenetriaminepentaacetic acid, triethylenetetramine hexaacetic acid and alkali metal salts or alkaline earth metal salts thereof, (3) aminotrimethylenephosphonic acid, 1-hydroxyethylidene-1,1-diphosphonic acid, ethylenediaminetetramethylenephosphone Acid, diethylenetriaminepentamethylenephosphonic acid, aminotrimethylenephosphonic acid N-oxide and alkali metal salts or alkaline earth metal salts thereof, (4) acrylic acid and methacrylic acid Monomers or copolymers of monomers, acrylic acid-maleic acid copolymer, poly α-hydroxyacrylic acid and alkali metal salts thereof, (5) citric acid, succinic acid, malic acid, fumaric acid, tartaric acid, malon One or more selected from polycarboxylic acids selected from acids and maleic acids and alkali metal salts thereof, (6) alkylglycine-N, N-diacetic acid, aspartic acid-N, N-diacetic acid, serine-N , N-diacetic acid, glutamic acid diacetic acid, ethylenediamine disuccinic acid, or a salt thereof.

  The anti-residential fungi of the present invention further include additives such as oils, higher fatty acids, silicones, pH adjusters, thickeners, suspending agents, powder components, natural extracts, pigments, and fragrances. Can be blended as appropriate, stirred and mixed to be dispersed or dissolved, and used to produce an antifungal composition.

Here, as pH adjusters, acid agents such as inorganic acids such as hydrochloric acid and sulfuric acid, organic acids such as citric acid, succinic acid, malic acid, fumaric acid, tartaric acid, malonic acid, maleic acid, sodium hydroxide and water Alkaline agents such as sodium carbonate and potassium carbonate such as potassium oxide, ammonia and derivatives thereof, amine salts such as monoethanolamine, diethanolamine, and triethanolamine may be used alone or in combination. In addition, these acid agents and alkali agents may be used in combination as a buffer system.
The antifungal composition is preferably adjusted so that the pH at 20 ° C. is 2 to 12, and particularly preferably 4 to 11 from the viewpoint of antibacterial properties. .

From the viewpoint of antibacterial activity, the content of the component (A) in the antifungal agent composition of the present invention is preferably 1 to 6000 ppm, more preferably 2.5 to 5000 ppm, and even more preferably 5 to 4000 ppm.
The content of the organic solvent of component (B) is preferably 3000 ppm or more, more preferably 4000 ppm or more, and even more preferably 5000 ppm or more. However, the component (B) is preferably about 100000 ppm or less from the viewpoint of substrate damage and blending convenience.
Moreover, when using the organic solvent of a component (B) at 5000-10000 ppm, it is preferable to make a component (A) into 100 ppm-6000 ppm, and when using a component (B) at a higher concentration than 10000 ppm, for example, 10000-40000 ppm, The component (A) is preferably 1 ppm to 3000 ppm.

  The anti-residential fungal agent of the present invention and the anti-fungal agent composition containing the same cause microbial contamination in the living environment, particularly in living spaces (such as bathrooms, kitchens, washrooms, and toilets) where temperature and humidity are likely to be high. Hard surfaces in easy places (for example, kitchens, bathrooms, toilets, washstands, etc., walls and floors, bottoms of washbasins, bottoms of bottles such as shampoo, drains, faucets, draft lines in toilet toilets, Used by applying before or after the generation of fungus in the living environment or black stains derived from it on appliances and equipment such as bathroom doors and windows, etc.) be able to. Here, application | coating is not specifically limited, Applying a composition directly to an object surface, filling spraying apparatuses, such as a trigger and aerosol, and spraying are mentioned.

Hereinafter, the present invention will be described in more detail based on examples.
Example 1 Combined Effect of Benzyl Alcohol on Antibacterial Activity of Octylbenzyldimethylammonium Chloride As a test strain, isolated from a bathroom in a living environment using Potato Dextrose Agar (PDA) (Difco) + Chloramphenicol (50 μg / ml) as a medium. In addition, Cladosporium sp. PA-4 strain was used in which the bacterial species was identified by microscopic observation of colony shape, spores, etc. and gene analysis of 28S rRNA gene D2 region. To the Cladosporium sp . PA-4 strain cultured on a PDA plate medium cultured at 25 ° C. for 1 week, physiological saline containing 0.05% Tween 80 was dropped, and the spore solution was collected by gently shaking. Add 1 ml of octylbenzyldimethylammonium chloride solution obtained by diluting sterile water, benzyl alcohol (BA), mixed solution of octylbenzyldimethylammonium chloride solution and BA to 10 μl of this spore solution. For 5 minutes at room temperature. And 100 microliters of liquids after contact were diluted with 900 microliters LP (Lecithin Polysorbate) dilution liquid (Wako Pure Chemical Industries), the test liquid was inactivated, and the number of surviving bacteria was calculated | required by the agar smear method. The results are shown in Table 1.

  From Table 1, in the octyl benzyl dimethyl ammonium chloride density | concentration of 250-6000 ppm, the improvement of the extremely high antimicrobial force was confirmed by using benzyl alcohol together.

Example 2 Evaluation of antibacterial activity against living environmental fungi (1)
As test strains, purchased strains and isolates of fungal species that were often isolated from the living environment were used.
As purchased strains, Cladosporium cladosporioides NBRC6348, Aspergillus niger NBRC6341, Aspergillus flavus NBRC6343, Penicillium citrinum NBRC6352, Aureobasidium pullulans NBRC6353 were used.
The isolate was isolated from bathroom and clothing in the living environment using Poteto Dextrose Agar (PDA) (Difco) + Chloramphenicol (50 μg / ml) as the medium, observation of the colony shape, spore, etc. under microscope and 28S rRNA gene D2 region Alternalia sp. A-BW strain, Phoma sp. A-BT strain, and Exophiala sp. Pc01 strain, for which bacterial species were identified by genetic analysis, were used.

  A spore solution was recovered from each bacterium by the same method as in Example 1. To 10 μl of this spore solution, add 1 ml of octylbenzyldimethylammonium chloride solution, benzyl alcohol solution, octylbenzyldimethylammonium chloride and benzyl alcohol mixed solution obtained by diluting sterile water, The contact was made at room temperature for 5 minutes. And 100 microliters of liquids after contact were diluted with 900 microliters LP (Lecithin Polysorbate) dilution liquid (Wako Pure Chemical Industries), the test liquid was inactivated, and the number of surviving bacteria was calculated | required by the agar smear method. The results are shown in Table 2.

  Table 2 shows that octylbenzyldimethylammonium chloride has a concentration of benzyl alcohol of 5000 ppm or more at various concentrations of octylbenzyldimethylammonium chloride, which has no antibacterial property alone or exhibits a weak antibacterial property, against various fungi that are well separated from the living environment. In addition, extremely high antibacterial properties were confirmed in a short time.

Example 3 Evaluation of antibacterial activity against living environmental fungi (2)
The spore solution of Cladosporium sp. PA-4 strain, which is a bathroom isolate, was recovered in the same procedure as in Example 1. For 10 μl of this spore solution, 1 ml of octylbenzyldimethylammonium chloride solution obtained by diluting sterilized water, various solvents shown in Table 3, mixed solution of octylbenzyldimethylammonium chloride and various solvents Added and contacted at room temperature for 5 minutes. And 100 microliters of liquids after contact were diluted with 900 microliters LP (Lecithin Polysorbate) dilution liquid (Wako Pure Chemical Industries), the test liquid was inactivated, and the number of surviving bacteria was calculated | required by the agar smear method. The results are shown in Table 3.

  From Table 3, the antibacterial improvement was confirmed by adding all the solvents used for the test to octylbenzyldimethylammonium chloride.

Example 4 Evaluation of antibacterial activity against living environmental fungi (3)
A fungal species purchased strain and a spore solution of the isolate that were well separated from the living environment were prepared in the same procedure as in Example 1. As purchased strains, Cladosporium cladosporioides NBRC6348 strain and Penicillium citrinum NBRC6352 strain were used. Isolates were Cladosporium sp. PA-4 and Phoma sp. A-BT. Further, benzyl alcohol was added to each concentration shown in Table 4 with respect to the dodecylbenzyldimethylammonium chloride and didecyldimethylammonium chloride solution obtained by diluting with sterilized water. 10 μl of each spore solution is added to 1 ml of a mixed solution of these two kinds of quaternary ammonium salts and a solvent or one of these agents, brought into contact at room temperature for 5 minutes, and then diluted to 1/10 with LP diluent. Thus, the test solution was inactivated, and the number of surviving bacteria was determined by the agar smear method. The results are shown in Table 4.

  From Table 4, a high effect was obtained at room temperature for a short time by adding benzyl alcohol to dodecylbenzyldimethylammonium chloride and didecyldimethylammonium chloride.

Example 5 Evaluation of antibacterial activity against living environmental fungi (4)
The spore solution of Cladosporium sp. PA-4 was recovered in the same manner as in Example 1. To 10 μl of this spore solution, 1 ml of octylbenzyldimethylammonium chloride obtained by diluting sterilized water was added and contacted at room temperature for 5 to 180 minutes. The test was carried out with and without the addition of 21628 ppm final concentration of benzyl alcohol. The results are shown in Table 5.

  By adding benzyl alcohol, octylbenzyldimethylammonium chloride can be contacted at a high concentration (1000 ppm) for a long time (180 minutes) with only a short contact time of only 5 minutes using an octylbenzyldimethylammonium chloride concentration of 250 ppm. Unobtainable high antibacterial activity was obtained.

Example 6 Evaluation of antibacterial performance against dirt in the actual environment The packing with scum dirt was collected from an actual bathroom. This was cut into 10 × 4 × 1 (mm) and subjected to an antibacterial test. The antibacterial test was carried out by putting packing into 500 ml, 5000 ppm dodecylbenzyldimethylammonium chloride with and without final concentrations of 10000 and 20000 ppm benzyl alcohol added to 1 ml. After conducting a contact test at room temperature for 5 minutes, transfer the sections to a test tube containing 1 mL of LP diluent, vigorously agitate with a vortex mixer to detach and disperse the bacteria, and then add PDA + chloramphenicol 50 The antibacterial activity on the wrinkles present on the packing surface was evaluated by applying to a μg / ml medium and measuring the number of bacteria.

  As shown in Table 6, high antifungal activity was obtained in a short time by adding benzyl alcohol (BA) to dodecylbenzyldimethylammonium chloride against molds present in the actual bathroom.

Claims (7)

An anti-residential fungus agent comprising a combination of the following components (A) and (B).
(A) One or more quaternary ammonium salts selected from dialkyldimethylammonium salts and alkylbenzyldimethylammonium salts (B) benzyl alcohol, diethylene glycol monobenzyl ether, 2-benzyloxyethanol, 1- (2-butoxy-1 One or more organic solvents selected from -methylethoxy) propan-2-ol, 1-pentanol and 1-phenoxy-2-propanol   The anti-residential fungus agent according to claim 1, which exhibits an effect of reducing the number of bacteria of 1 log or more by contacting the living environment fungus within 5 minutes without applying heat treatment.   The anti-residential environmental fungus according to claim 1 or 2, wherein the quaternary ammonium salt of (A) is at least one selected from octylbenzyldimethylammonium chloride, dodecylbenzyldimethylammonium chloride and didecyldimethylammonium chloride.   The organic solvent of (B) is benzyl alcohol, The anti-residential environmental fungus according to any one of claims 1 to 3.   The antifungal agent composition containing the anti-residential fungi agent of any one of Claims 1-4.   The composition according to claim 5, wherein the composition contains 5 to 6000 ppm of component (A) and 5000 ppm or more of component (B).   (A) One or more quaternary ammonium salts selected from dialkyldimethylammonium salts and alkylbenzyldimethylammonium salts are added to (B) benzyl alcohol, diethylene glycol monobenzyl ether, 2-benzyloxyethanol, 1- (2-butoxy 1-methylethoxy) propan-2-ol, 1-pentanol and 1-phenoxy-2-propanol are used in combination with one or more organic solvents, wherein said quaternary against dwelling environmental fungi A method for enhancing the antibacterial properties of ammonium salts.