JP2012166181A - Heating/cooling mechanism of chemical reactor, and chemical reactor excellent in heating/cooling mechanism - Google Patents
Heating/cooling mechanism of chemical reactor, and chemical reactor excellent in heating/cooling mechanism Download PDFInfo
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- 238000001816 cooling Methods 0.000 title claims abstract description 71
- 238000010438 heat treatment Methods 0.000 title claims abstract description 51
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 96
- 239000007788 liquid Substances 0.000 claims abstract description 79
- 239000000110 cooling liquid Substances 0.000 claims abstract description 25
- 230000004044 response Effects 0.000 claims abstract description 7
- 239000002826 coolant Substances 0.000 claims description 50
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- 238000003756 stirring Methods 0.000 claims description 8
- 238000007664 blowing Methods 0.000 claims description 7
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- 238000007599 discharging Methods 0.000 claims description 5
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Abstract
Description
本発明は、化学反応装置の改良、詳しくは、反応槽内の液剤の加熱・冷却効率を向上することができ、しかも、ヒートショックによる器具の破損も防止できる化学反応装置の加熱冷却機構、及び加熱冷却機能に優れた化学反応装置に関するものである。 The present invention is an improvement of a chemical reaction apparatus, specifically, a heating / cooling mechanism of a chemical reaction apparatus that can improve the heating / cooling efficiency of a liquid agent in a reaction tank and that can also prevent damage to equipment due to heat shock, and The present invention relates to a chemical reaction apparatus excellent in heating and cooling functions.
周知のとおり、医薬品や化学物質の多くは、複数の薬剤を混ぜ合わせこれらを化学反応させることによって製造されている。しかし、化学反応の反応速度や反応後の生成物は、薬剤の温度や圧力、また触媒の有無等によって大きく変わるため、生産効率や歩留等の視点から工業生産に適した反応条件を調べる必要がある。 As is well known, many pharmaceuticals and chemical substances are produced by mixing a plurality of drugs and chemically reacting them. However, the reaction rate of the chemical reaction and the product after the reaction vary greatly depending on the temperature and pressure of the chemical and the presence or absence of a catalyst. Therefore, it is necessary to investigate the reaction conditions suitable for industrial production from the viewpoint of production efficiency and yield. There is.
また、上記反応条件を調べる試験研究においては、薬剤の温度を調節可能な反応装置が使用され、この種の装置としては、薬剤を収容する反応槽の周囲にジャケットを設け、このジャケット内に高温または低温の熱媒液を循環供給することにより薬剤の加熱冷却を行うものが知られている。 Further, in the test research for examining the above reaction conditions, a reaction apparatus capable of adjusting the temperature of the drug is used. As this type of apparatus, a jacket is provided around the reaction tank containing the drug, and the temperature inside the jacket is high. Or what heat-cools a chemical | medical agent by circulatingly supplying a low-temperature heat-medium liquid is known.
しかしながら、上記反応装置は、単一の熱媒液によって加熱と冷却の両方を行わなければならなかったため、加熱から冷却(または冷却から加熱)に切り替える際に熱媒液の温度を昇降させる必要が生じ、これが結果的に時間のロスとなって加熱・冷却の切り替えを迅速に行うことができなかった。 However, since the reaction apparatus had to perform both heating and cooling with a single heat transfer liquid, it is necessary to raise and lower the temperature of the heat transfer liquid when switching from heating to cooling (or from cooling to heating). As a result, this resulted in time loss, and switching between heating and cooling could not be performed quickly.
そこで、従来においては、ジャケット内の熱媒液を冷却にのみ使用し、加熱手段を別に設けた反応装置も開発されたが(特許文献１参照)、この装置についても、冷却液の液量調節は可能であるものの、基本的にジャケット内に冷却液を残した状態で加熱が行われるため、熱が冷却液に吸収されて効率良く加熱を行うことができなかった。 Thus, in the past, a reaction apparatus was also developed in which the heating medium liquid in the jacket was used only for cooling and a separate heating means was provided (see Patent Document 1). However, since the heating is basically performed with the cooling liquid left in the jacket, the heat is absorbed by the cooling liquid and the heating cannot be performed efficiently.
しかも、上記反応装置において、ジャケットや反応槽に内部を透視可能なガラスを使用し、更に加熱手段に薬剤を100℃以上の高温まで加熱可能な電熱ヒーター等を用いた場合には、加熱後に薬剤をいきなり低温の冷却液で冷やすと、薬剤と一緒に反応槽やジャケットの温度も急激に低下して、ヒートショックによりガラスが破損する危険もあった。 Moreover, in the above reaction apparatus, when glass that can see through the inside is used for the jacket or the reaction tank, and when an electric heater that can heat the drug to a high temperature of 100 ° C. or higher is used as the heating means, When suddenly cooled with a low-temperature cooling liquid, the temperature of the reaction tank and the jacket suddenly dropped with the chemicals, and there was a risk of breakage of the glass due to heat shock.
一方、従来においては、高温に加熱された薬剤をエアブローによって冷却する技術も公知となっているが(例えば、特許文献２参照)、このようなエアブローによる冷却は一般的に温度降下が非常に緩やかであるため、冷却に時間がかかり、特に100℃以上の高温から0℃以下の低温まで冷却する場合に冷却効率が悪かった。 On the other hand, conventionally, a technique for cooling a medicine heated to a high temperature by air blowing is also known (for example, see Patent Document 2). However, cooling by such air blowing generally has a very slow temperature drop. Therefore, it takes time for cooling, and the cooling efficiency is particularly poor when cooling from a high temperature of 100 ° C. or higher to a low temperature of 0 ° C. or lower.
そこで本発明は、上記の如き問題に鑑みて為されたものであり、その目的とするところは、反応槽内に収容した液剤の加熱・冷却効率を高めることができ、しかも、ヒートショックによる器具の破損も防止できる化学反応装置の加熱冷却機構、及び加熱冷却機能に優れた化学反応装置を提供することにある。 Therefore, the present invention has been made in view of the above problems, and the object of the present invention is to improve the heating / cooling efficiency of the liquid agent accommodated in the reaction tank, and to further provide a device by heat shock. An object of the present invention is to provide a heating / cooling mechanism for a chemical reaction apparatus that can prevent the damage of the chemical reaction apparatus, and a chemical reaction apparatus having an excellent heating / cooling function.
本発明者が上記課題を解決するために採用した手段を添付図面を参照して説明すれば次のとおりである。 Means employed by the present inventor for solving the above-described problems will be described with reference to the accompanying drawings.
即ち、本発明は、化学反応させる液剤Ｌを収容可能な反応槽１と；前記反応槽１内の液剤Ｌの温度を検知するための温度センサ２と；前記反応槽１内の液剤Ｌを加熱するためのヒーター装置３と；前記反応槽１の胴部を被覆するように設けられ、かつ、内部に冷却液Ｃを収容可能なジャケット４と；前記ジャケット４に循環路52を介して接続された貯溜タンク51を有し、かつ、ジャケット４内に冷却液Ｃを送り出すための循環ポンプ53、およびジャケット４内から回収した冷却液Ｃを再冷却するための冷却手段54を備えたチラーユニット５と；前記ジャケット４に接続されてジャケット４内に圧縮エアＡを供給可能なエアブロー装置６と；前記ヒーター装置３の始動・停止、及び冷却液Ｃの給排液弁Ｖ1・Ｖ2と圧縮エアＡの給排気弁Ｖ3・Ｖ4の開閉を制御可能な制御装置７とを含んで構成する一方、
前記制御装置７には、液剤Ｌを加熱するときにヒーター装置３への始動命令に応じて冷却液Ｃの給液弁Ｖ1を閉じ、ジャケット４内に残った冷却液Ｃを開放された排気弁Ｖ4或いは排液弁Ｖ2から排出する第一の制御機能と、液剤Ｌを冷却するときに温度センサ２から送られた液剤Ｌの温度が所定の閾値を下回ったところで圧縮エアＡの給気弁Ｖ3を閉じ、冷却液Ｃの給液弁Ｖ1を開いてジャケット４内を冷却液Ｃで満たす第二の制御機能とを備えた点に特徴がある。
That is, the present invention includes a reaction tank 1 capable of containing a liquid L to be chemically reacted; a temperature sensor 2 for detecting the temperature of the liquid L in the reaction tank 1; and heating the liquid L in the reaction tank 1. A heater device 3 for carrying out the operation; a jacket 4 provided so as to cover the body portion of the reaction tank 1 and capable of accommodating the coolant C therein; and connected to the jacket 4 via a circulation path 52 A chiller unit 5 having a storage tank 51 and having a circulation pump 53 for sending the coolant C into the jacket 4 and a cooling means 54 for re-cooling the coolant C recovered from the jacket 4. An air blow device 6 connected to the jacket 4 and capable of supplying compressed air A into the jacket 4; starting and stopping of the heater device 3, and supply and discharge valves V 1 and V 2 for the coolant C and compression Air A supply / exhaust valves V 3 and V 4 While including the control device 7 capable of controlling opening and closing,
The controller 7 closes the supply valve V 1 of the coolant C in response to a start command to the heater device 3 when the liquid L is heated, and the exhaust C with the coolant C remaining in the jacket 4 opened. Supply of compressed air A when the temperature of the liquid L sent from the temperature sensor 2 when the liquid L is cooled from the first control function discharged from the valve V 4 or the drain valve V 2 and cooling the liquid L is below a predetermined threshold. the closed valves V 3, it is characterized by opening the liquid supply valve V 1 of the coolant C to the jacket 4 in that a second control functions to meet the cooling liquid C.
なお、本明細書中で使用する「チラーユニット」とは、冷却液を循環させて対象物の冷却を行う液冷却装置を意味する。 In addition, the “chiller unit” used in this specification means a liquid cooling device that circulates a cooling liquid and cools an object.
また、上記ヒーター装置３については、反応槽１内に設置したインナーコイル31に直接電流を流して発熱させる抵抗加熱型、或いは反応槽１の下方に配置した電磁誘導コイル32に電流を流して、導電体から成る反応槽１本体または反応槽１内の攪拌翼11を渦電流により発熱させる誘導加熱型を採用することができる。 For the heater device 3, a current is passed through an inner coil 31 installed in the reaction tank 1 to generate heat by direct current flow, or an electromagnetic induction coil 32 disposed below the reaction tank 1. An induction heating type in which the main body of the reaction vessel 1 made of a conductor or the stirring blade 11 in the reaction vessel 1 generates heat by eddy current can be employed.
また本発明では、上記ジャケット４の上側に圧縮エアＡの給気口43を設けると共に、ジャケット４の下側に排気口44を設け、更に第一の制御機能において圧縮エアＡの給排気弁Ｖ3・Ｖ4を一定時間だけ開放する機能を制御装置７に備えることにより、ジャケット４内に残った冷却液Ｃを圧縮エアＡによって強制排出可能とすることもできる。 In the present invention, the compressed air A supply port 43 is provided above the jacket 4 and the exhaust port 44 is provided below the jacket 4, and the compressed air A supply / exhaust valve V is provided in the first control function. By providing the control device 7 with a function of opening 3 · V 4 for a predetermined time, the cooling liquid C remaining in the jacket 4 can be forcedly discharged by the compressed air A.
また更に、本発明では、上記チラーユニット５の循環路52を、給排液弁Ｖ1・Ｖ2よりもジャケット４寄りの位置で分岐させて、エアブロー装置６を接続する圧縮エアＡの給気路61および排気路62を設けることにより、ジャケット４に設けた冷却液Ｃの給排液口41・42を圧縮エアＡの給排気口43・44として兼用することもできる。 Furthermore, in the present invention, the supply path of the compressed air A that connects the air blowing device 6 by branching the circulation path 52 of the chiller unit 5 at a position closer to the jacket 4 than the supply / drainage valves V 1 and V 2. By providing the passage 61 and the exhaust passage 62, the supply / exhaust ports 41 and 42 for the coolant C provided in the jacket 4 can also be used as the supply / exhaust ports 43 and 44 for the compressed air A.
そしてまた、本発明では、上記ヒーター装置３への始動・停止命令の送信、および第二の制御機能の閾値の設定を行うための入力手段と、液剤Ｌの温度変化をモニタリングするための出力手段とを備えた入出力装置８を、有線または無線の伝送路81を介して制御装置７に接続することにより、反応装置から離れた場所での管理を可能とすることもできる。 In the present invention, the input means for transmitting the start / stop command to the heater device 3 and setting the threshold value of the second control function, and the output means for monitoring the temperature change of the liquid L By connecting the input / output device 8 including the above to the control device 7 via a wired or wireless transmission path 81, it is possible to enable management at a place away from the reaction device.
また、上記反応装置の入出力に関しては、複数の反応装置に個別に配設された制御装置７・７…を共通の入出力装置８にまとめて接続することにより、複数の装置を一括して管理することもできる。 In addition, regarding the input / output of the reaction apparatus, the control apparatuses 7, 7... Individually arranged in the plurality of reaction apparatuses are collectively connected to the common input / output apparatus 8, thereby collectively connecting the plurality of apparatuses. It can also be managed.
一方、本発明では、上記ヒーター装置３を、反応槽１が嵌装されるアルミブロックＢに付設して、アルミブロックＢを介して反応槽１内の液剤Ｌを加熱可能とすると共に、前記アルミブロックＢの内部に冷却液Ｃ或いは圧縮エアＡを通過させるための冷却流路Ｐを設けてこれを液剤Ｌの冷却手段とすることもできる。なお、その場合には、チラーユニット５の循環路52、およびエアブロー装置６を冷却流路Ｐの出入口に接続する。 On the other hand, in the present invention, the heater device 3 is attached to the aluminum block B in which the reaction tank 1 is fitted so that the liquid L in the reaction tank 1 can be heated via the aluminum block B, and the aluminum A cooling flow path P for allowing the cooling liquid C or the compressed air A to pass therethrough may be provided inside the block B, and this may be used as a cooling means for the liquid L. In this case, the circulation path 52 of the chiller unit 5 and the air blow device 6 are connected to the inlet / outlet of the cooling channel P.
本発明では、液剤を収容する反応槽の周囲に設けたジャケットに、冷却液を循環供給するためのチラーユニットと、圧縮エアを供給するためのエアブロー装置とを接続し、更にヒーター装置およびバルブ類を制御する制御装置に、加熱時にジャケット内に残った冷却液を排出する機能を付与したことにより、ジャケット内を完全に空にした状態で液剤の加熱を行うことができるため、熱の分散を防いで加熱効率を向上することができる。 In the present invention, a chiller unit for circulating and supplying a cooling liquid and an air blowing device for supplying compressed air are connected to a jacket provided around a reaction vessel containing a liquid agent, and further a heater device and valves Since the controller that controls the heat treatment is given a function to discharge the coolant remaining in the jacket during heating, the liquid agent can be heated in a state where the jacket is completely emptied. It can prevent and improve heating efficiency.
また本発明では、上記制御装置に、冷却時における冷却方式の切り替え機能も付与していることから、液剤をヒートショックが起こらない温度までエアブローで緩やかに冷却した後、冷却液に切り替えれば、液剤を設定温度まで高速に冷却することが可能となり、これによって冷却効率を損なわずにヒートショックの防止を図ることができる。 Further, in the present invention, since the control device is also provided with a cooling system switching function at the time of cooling, if the liquid agent is slowly cooled by air blow to a temperature at which heat shock does not occur and then switched to the cooling liquid, Can be cooled to the set temperature at high speed, thereby preventing heat shock without impairing the cooling efficiency.
したがって、本発明により、実験対象となる液剤の加熱・冷却を短時間で行うことができ、しかも、作業者が怪我をする虞れのあるヒートショックによる器具の破損も防止できる機能性および安全性に優れた化学反応装置を提供できることから、本発明の実用的利用価値は頗る高い。 Therefore, according to the present invention, it is possible to perform heating and cooling of the liquid agent to be tested in a short time, and to prevent damage to the instrument due to heat shock that may cause injury to the operator. Therefore, the practical use value of the present invention is very high.
『実施例１』
まず、本発明の実施例１について、図１から図８に基いて説明する。同図において、符号１で指示するものは、反応槽であり、符号２で指示するものは、温度センサである。また符号３で指示するものは、ヒーター装置であり、符号４で指示するものは、ジャケットである。また、符号５で指示するものは、チラーユニットであり、符号６で指示するものは、エアブロー装置である。また符号７で指示するものは、制御装置であり、符号８で指示するものは、入出力装置である。
“Example 1”
First, a first embodiment of the present invention will be described with reference to FIGS. In the figure, what is indicated by reference numeral 1 is a reaction tank, and what is indicated by reference numeral 2 is a temperature sensor. What is indicated by reference numeral 3 is a heater device, and what is indicated by reference numeral 4 is a jacket. Moreover, what is indicated by reference numeral 5 is a chiller unit, and what is indicated by reference numeral 6 is an air blowing device. What is indicated by reference numeral 7 is a control device, and what is indicated by reference numeral 8 is an input / output device.
この実施例１では、化学反応させる液剤Ｌを収容可能で、かつ、内部に駆動源Ｍにより回転する攪拌翼11を備えた反応槽１(材質:耐熱ガラス)に対して、槽内の液剤Ｌの温度を検知するための温度センサ２、および反応槽１内の液剤Ｌを加熱するためのヒーター装置３を付設している(図１参照)。また、ヒーター装置３に関しては、反応槽１内に設置したインナーコイル31に直接電流を流して発熱させる抵抗加熱型のものを使用している。 In the first embodiment, the liquid agent L in the tank can be contained in the reaction tank 1 (material: heat-resistant glass) that can contain the liquid agent L to be chemically reacted and has the stirring blade 11 that is rotated by the drive source M inside. And a heater device 3 for heating the liquid agent L in the reaction tank 1 (see FIG. 1). As for the heater device 3, a resistance heating type device is used in which a current is directly supplied to the inner coil 31 installed in the reaction tank 1 to generate heat.
そしてまた、上記反応槽１には、図２に示すように冷却液Ｃを収容可能なスペースを内側に有するジャケット４(材質:ステンレス)を胴部を被覆するように設け、更にこのジャケット４に設けた給排液口41・42には、冷却液Ｃの貯溜タンク51を備えたチラーユニット５を循環路52を介して接続している。 Further, in the reaction tank 1, as shown in FIG. 2, a jacket 4 (material: stainless steel) having a space in which the coolant C can be accommodated is provided so as to cover the body portion. A chiller unit 5 having a storage tank 51 for the coolant C is connected to the supply / drain ports 41 and 42 provided through a circulation path 52.
なお、上記チラーユニット５の貯溜タンク51は、ジャケット４内に冷却液Ｃを送り出すための循環ポンプ53、およびジャケット４内から回収した冷却液Ｃを再冷却するための冷却手段54を備えており、設定された所定温度の冷却液Ｃをジャケット４内に常時供給することができる。 The storage tank 51 of the chiller unit 5 includes a circulation pump 53 for sending the coolant C into the jacket 4 and a cooling means 54 for recooling the coolant C recovered from the jacket 4. The coolant C having a set predetermined temperature can be constantly supplied into the jacket 4.
一方、上記ジャケット４に設けた給排気口43・44には、図３に示すようにジャケット４内に圧縮エアＡを供給可能なエアブロー装置６を接続している。なお本実施例では、チラーユニット５の循環路52を、給排液弁Ｖ1・Ｖ2よりもジャケット４寄りの位置で分岐させて、圧縮エアＡの給気路61および排気路62を設けており、これによってジャケット４の給排液口41・42を圧縮エアＡの給排気口43・44としても使用できるようにしている。 On the other hand, an air blow device 6 capable of supplying compressed air A into the jacket 4 is connected to the air supply / exhaust ports 43 and 44 provided in the jacket 4 as shown in FIG. In this embodiment, the circulation path 52 of the chiller unit 5 is branched at a position closer to the jacket 4 than the supply / drainage valves V 1 and V 2 , and the supply path 61 and the exhaust path 62 for the compressed air A are provided. Thus, the supply / discharge liquid ports 41 and 42 of the jacket 4 can be used as the supply / exhaust ports 43 and 44 of the compressed air A.
また更に、上記反応装置には、ヒーター装置３の始動・停止、及びチラーユニット５の循環路52に設けた冷却液Ｃの給排液弁Ｖ1・Ｖ2と圧縮エアＡの給排気路61・62に設けた給排気弁Ｖ3・Ｖ4の開閉を制御可能な制御装置７を付設している。 Furthermore, the reaction apparatus includes start and stop of the heater device 3, and supply / discharge valves V 1 and V 2 for the coolant C provided in the circulation path 52 of the chiller unit 5 and a supply / exhaust path 61 for the compressed air A. A control device 7 capable of controlling the opening / closing of the supply / exhaust valves V 3 and V 4 provided at 62 is attached.
そして、上記制御装置７には、液剤Ｌを加熱するときにヒーター装置３への始動命令に応じて冷却液Ｃの給液弁Ｖ1を閉じ、ジャケット４内に残った冷却液Ｃを開放された排気弁Ｖ4或いは排液弁Ｖ2から排出する第一の制御機能を付与している。 The controller 7 closes the supply valve V 1 of the coolant C in response to a start command to the heater device 3 when heating the liquid L, and opens the coolant C remaining in the jacket 4. The first control function of discharging from the exhaust valve V 4 or the drain valve V 2 is provided.
また実施例１では、上記第一の制御機能において圧縮エアＡの給排気弁Ｖ3・Ｖ4を一定時間だけ開放する機能を制御装置７に備え、更にジャケット４の上側に圧縮エアＡの給気口43を、ジャケット４の下側に排気口44を設けることにより、図４に示すようにジャケット４内に残った冷却液Ｃを圧縮エアＡによって強制排出可能としている。 In the first embodiment, the control device 7 has a function of opening the supply / exhaust valves V 3 and V 4 of the compressed air A for a predetermined time in the first control function, and the compressed air A is supplied to the upper side of the jacket 4. By providing the air outlet 43 and the exhaust port 44 below the jacket 4, the cooling liquid C remaining in the jacket 4 can be forcibly discharged by the compressed air A as shown in FIG. 4.
また更に、上記制御装置７には、第一の制御機能に加え、液剤Ｌを冷却するときに温度センサ２から送られた液剤Ｌの温度が所定の閾値を下回ったところで、図５に示すように圧縮エアＡの給気弁Ｖ3を閉じ、冷却液Ｃの給液弁Ｖ1を開いてジャケット４内を冷却液Ｃで満たす第二の制御機能を付与している。 Furthermore, in addition to the first control function, the control device 7 has a configuration in which the temperature of the liquid L sent from the temperature sensor 2 when the liquid L is cooled falls below a predetermined threshold as shown in FIG. The air supply valve V 3 for the compressed air A is closed, the liquid supply valve V 1 for the coolant C is opened, and the second control function of filling the jacket 4 with the coolant C is added.
また、上記反応装置には、ヒーター装置３への始動・停止命令の送信、および第二の制御機能の閾値の設定を行うための入力手段と、液剤Ｌの温度変化をモニタリングするための出力手段とを備えた入出力装置８(本実施例では、「パソコン」)を、有線または無線の伝送路81を介して制御装置７に接続している。これにより、反応装置から離れた場所での管理が可能となる。 The reaction apparatus includes an input means for transmitting a start / stop command to the heater device 3 and setting a threshold value for the second control function, and an output means for monitoring a temperature change of the liquid L. Is connected to the control device 7 via a wired or wireless transmission path 81. Thereby, the management in the place away from the reaction apparatus is attained.
なお、図６の配線図は、本実施例における制御装置７の第一の制御機能や第二の制御機能、および他の機器との接続関係を示す資料である。 Note that the wiring diagram of FIG. 6 is data showing the first control function and the second control function of the control device 7 in this embodiment, and the connection relationship with other devices.
［効果の検証試験(Ｉ)］
次に、上記反応装置を使用して行った効果の検証試験(Ｉ)について説明する。この検証試験(Ｉ)では、反応槽１に収容する液剤Ｌに水(200ml)を使用し、この液剤Ｌをヒーター装置３を用いて出力100Ｗで加熱した。また検証試験(Ｉ)では、一方の装置をジャケット４内から冷却液Ｃを抜いた状態で加熱し、もう一方の装置をジャケット４内に冷却液Ｃ(冷水)を入れたままの状態で加熱した。
[Effectiveness verification test (I)]
Next, the verification test (I) of the effect performed using the reaction apparatus will be described. In this verification test (I), water (200 ml) was used as the liquid agent L accommodated in the reaction tank 1, and this liquid agent L was heated at an output of 100 W using the heater device 3. In the verification test (I), one apparatus is heated with the coolant C removed from the jacket 4, and the other apparatus is heated with the coolant C (cold water) remaining in the jacket 4. did.
その結果、図７に示すように、ジャケット４内から冷却液Ｃを抜いた状態で加熱した方が、ジャケット４内に冷却液Ｃを入れた状態のまま加熱するよりも液剤Ｌの加熱効率が向上することが検証された。 As a result, as shown in FIG. 7, heating with the coolant C removed from the jacket 4 has higher heating efficiency of the liquid L than heating with the coolant C in the jacket 4. It was verified to improve.
［効果の検証試験(II)］
次に、上記反応装置を使用して行った効果の検証試験(II)について説明する。この検証試験(II)では、制御装置７の第二の制御機能における、エア冷却から液冷却に切り替える閾値を60℃に設定した。また、液剤Ｌには水を、冷却液Ｃには冷水を使用した。
[Effectiveness verification test (II)]
Next, the verification test (II) of the effect performed using the reaction apparatus will be described. In this verification test (II), the threshold value for switching from air cooling to liquid cooling in the second control function of the control device 7 was set to 60 ° C. Moreover, water was used for the liquid L, and cold water was used for the cooling liquid C.
その結果、図８に示すように、液剤Ｌが120℃から50℃までは平均-1.7℃／minのスピードで冷却が緩やかに進み、その後、50℃から-20℃までは平均-4.7℃／minのスピードで高速に冷却が進んだ。また、ヒートショックの予兆は全くなかった。 As a result, as shown in FIG. 8, the liquid agent L gradually cooled at an average speed of −1.7 ° C./min from 120 ° C. to 50 ° C., and thereafter, an average of −4.7 ° C./min from 50 ° C. to −20 ° C. Cooling advanced at a high speed of min. There was no sign of heat shock.
『実施例２』
次に、本発明の実施例２について、図９に基いて説明する。この実施例２では、ヒーター装置３に、反応槽１の下方に配置した電磁誘導コイル32に電流を流して、導電体から成る反応槽１本体を渦電流により発熱させる誘導加熱型のものを使用している(図９参照)。
“Example 2”
Next, a second embodiment of the present invention will be described with reference to FIG. In the second embodiment, the heater device 3 is of an induction heating type in which a current is passed through an electromagnetic induction coil 32 disposed below the reaction tank 1 to heat the reaction tank 1 body made of a conductor by eddy current. (See FIG. 9).
『実施例３』
次に、本発明の実施例３について、図１０及び図１１に基いて説明する。この実施例３では、ヒーター装置３に、反応槽１を嵌装可能な窪みを有するアルミブロックＢにヒーター装置３を付設して、アルミブロックＢを介して反応槽１内の液剤Ｌを加熱できるように構成している(図１０参照)。
“Example 3”
Next, a third embodiment of the present invention will be described with reference to FIGS. In Example 3, the heater device 3 is attached to the aluminum block B having a recess into which the reaction vessel 1 can be fitted to the heater device 3, and the liquid L in the reaction vessel 1 can be heated via the aluminum block B. (See FIG. 10).
また、上記アルミブロックＢの内部には、図１１(a)及び(b)に示すように冷却液Ｃ或いは圧縮エアＡを通過させるための冷却流路Ｐを螺旋状に設け、この冷却流路Ｐの出入口にチラーユニット５の循環路52、およびエアブロー装置６を接続している。 Further, inside the aluminum block B, as shown in FIGS. 11A and 11B, a cooling flow path P for allowing the coolant C or compressed air A to pass therethrough is provided in a spiral shape. The circulation path 52 of the chiller unit 5 and the air blowing device 6 are connected to the P inlet / outlet.
『実施例４』
次に、本発明の実施例３について、図１２に基いて説明する。この実施例１では、複数の反応装置に個別に配設した制御装置７・７…を共通の入出力装置８にまとめて接続しており、これによって複数の反応装置を一括して管理することが可能となる(図１２参照)。
Example 4
Next, Embodiment 3 of the present invention will be described with reference to FIG. In the first embodiment, the control devices 7, 7... Individually arranged in a plurality of reaction apparatuses are collectively connected to the common input / output device 8, thereby managing the plurality of reaction apparatuses collectively. (See FIG. 12).
本発明は、概ね上記のように構成されるが、本発明は図示の実施形態に限定されるものではなく、「特許請求の範囲」の記載内において種々の変更が可能であって、例えば、反応槽１及びジャケット４の材質には、ガラス等の無機材料またはステンレス等の金属材料を適宜選択して使用することができ、特に反応槽１及びジャケット４の両方を透明なガラス製とした場合には、液剤Ｌの反応を目で見て確認することができる。 The present invention is generally configured as described above. However, the present invention is not limited to the illustrated embodiment, and various modifications can be made within the description of “Claims”. The reaction vessel 1 and the jacket 4 can be made by appropriately selecting an inorganic material such as glass or a metal material such as stainless steel, particularly when both the reaction vessel 1 and the jacket 4 are made of transparent glass. The reaction of the liquid L can be visually confirmed.
また、反応槽１内で液剤Ｌを攪拌する手段としては、攪拌翼11の代わりに磁気で攪拌子を回転させるマグネティックスターラーを使用することもできる。また更に、ヒーター装置３に誘導加熱型のものを使用する場合には、反応槽１をガラス製とし攪拌翼11をステンレス製として、攪拌翼11を電磁誘導コイル32により発熱させることもできる。 As a means for stirring the liquid L in the reaction tank 1, a magnetic stirrer that rotates a stirrer magnetically instead of the stirring blade 11 can be used. Further, when an induction heating type heater is used for the heater device 3, the reaction vessel 1 can be made of glass, the stirring blade 11 can be made of stainless steel, and the stirring blade 11 can be heated by the electromagnetic induction coil 32.
そしてまた、ジャケット４に設ける冷却液Ｃの給排液口41・42と圧縮エアＡの給排気口43・44は別々に設けることもでき、また、ジャケット４内に残った冷却液Ｃの排出に関しても、圧縮エアＡによって排気口44から強制排出しなくても、排液口42から自然排出することもできる。 Further, the coolant C supply / exhaust ports 41 and 42 and the compressed air A supply / exhaust ports 43 and 44 provided in the jacket 4 can be provided separately, and the coolant C remaining in the jacket 4 can be discharged. In this case, the compressed air A can be naturally discharged from the liquid discharge port 42 without being forcedly discharged from the exhaust port 44.
他方また、チラーユニット５において循環させる冷却液Ｃには、冷水だけでなくＨＦＣやＨＣＦＣなどの冷媒を使用することもでき、上記何れのものも本発明の技術的範囲に属する。 On the other hand, as the coolant C circulated in the chiller unit 5, not only cold water but also refrigerants such as HFC and HCFC can be used, and any of the above belongs to the technical scope of the present invention.
近年、製薬業界や化学業界において、開発研究を目的とした薬剤の反応試験が頻繁に行われており、研究者からは機能性に優れた反応装置が求められている。また、反応装置には、化学反応を目視するために透明なガラス材を用いることも多いため、ヒートショック対策は実験作業を安全に行うための必須の課題である。 In recent years, drug reaction tests for the purpose of development research have been frequently performed in the pharmaceutical industry and the chemical industry, and researchers have demanded reaction devices with excellent functionality. In addition, since a transparent glass material is often used for the reaction apparatus to visually observe a chemical reaction, countermeasures against heat shock are an indispensable issue for safely performing experimental work.
そのような中で、本発明の化学反応装置の加熱冷却機構、及び加熱冷却機能に優れた化学反応装置は、薬剤の加熱・冷却を迅速に行うことができ、しかも、ヒートショックによって器具が破損する心配もない有用な技術であるため、その産業上の利用価値は非常に高い。 Under such circumstances, the heating / cooling mechanism of the chemical reaction device of the present invention and the chemical reaction device excellent in the heating / cooling function can quickly heat and cool the drug, and the instrument is damaged by heat shock. Because it is a useful technology without worrying about it, its industrial utility value is very high.
１ 反応槽
11 攪拌翼
２ 温度センサ
３ ヒーター装置
31 インナーコイル
32 電磁誘導コイル
４ ジャケット
41 給液口
42 排液口
43 給気口
44 排気口
５ チラーユニット
51 貯溜タンク
52 循環路
53 循環ポンプ
54 冷却手段
６ エアブロー装置
61 給気路
62 排気路
７ 制御装置
８ 入出力装置
81 伝送路
Ｌ 液剤
Ｍ 駆動源
Ｃ 冷却液
Ａ 圧縮エア
Ｖ 給排出弁
Ｂ アルミブロック
Ｐ 冷却流路
1 reaction tank
11 Stirring blade 2 Temperature sensor 3 Heater device
31 Inner coil
32 Electromagnetic induction coil 4 Jacket
41 Supply port
42 Drainage port
43 Air inlet
44 Exhaust port 5 Chiller unit
51 Storage tank
52 Circuit
53 Circulation pump
54 Cooling means 6 Air blow device
61 Air supply path
62 Exhaust path 7 Control device 8 Input / output device
81 Transmission path L Liquid agent M Drive source C Coolant A Compressed air V Supply / discharge valve B Aluminum block P Cooling path
Claims (9)
前記制御装置(７)には、液剤(Ｌ)を加熱するときにヒーター装置(３)への始動命令に応じて冷却液(Ｃ)の給液弁(Ｖ1)を閉じ、ジャケット(４)内に残った冷却液(Ｃ)を開放された排気弁(Ｖ4)或いは排液弁(Ｖ2)から排出する第一の制御機能と、液剤(Ｌ)を冷却するときに温度センサ(２)から送られた液剤(Ｌ)の温度が所定の閾値を下回ったところで圧縮エア(Ａ)の給気弁(Ｖ3)を閉じ、冷却液(Ｃ)の給液弁(Ｖ1)を開いてジャケット(４)内を冷却液(Ｃ)で満たす第二の制御機能とを備えたことを特徴とする化学反応装置の加熱冷却機構。 A reaction tank (1) capable of containing a liquid agent (L) to be chemically reacted; a temperature sensor (2) for detecting the temperature of the liquid agent (L) in the reaction tank (1); and the reaction tank (1) A heater device (3) for heating the liquid agent (L) therein; a jacket (covering the body of the reaction vessel (1)) and accommodating the coolant (C) therein ( 4) and a circulation pump (51) having a storage tank (51) connected to the jacket (4) via a circulation path (52), and for sending the coolant (C) into the jacket (4) 53), and a chiller unit (5) provided with a cooling means (54) for recooling the coolant (C) recovered from the jacket (4); and the jacket (4) connected to the jacket (4) ) An air blow device (6) capable of supplying compressed air (A) into the inside; and starting and stopping of the heater device (3), and a supply / discharge valve (V 1 ) (V 2 ) for the coolant (C) Compression Intake and exhaust valves (A) (V 3) (V 4) controllable control unit (7) opening and closing of the one that is comprise configure,
The controller (7) closes the coolant supply valve (V 1 ) in response to a start command to the heater device (3) when the liquid (L) is heated, and the jacket (4) A first control function for discharging the remaining coolant (C) from the opened exhaust valve (V 4 ) or drain valve (V 2 ), and a temperature sensor (2 ) When the temperature of the liquid agent (L) sent from the liquid drops below a predetermined threshold, the compressed air (A) supply valve (V 3 ) is closed and the cooling liquid (C) supply valve (V 1 ) is opened. And a second control function of filling the inside of the jacket (4) with the cooling liquid (C).
前記制御装置(７)には、液剤(Ｌ)を加熱するときにヒーター装置(３)への始動命令に応じて冷却液(Ｃ)の給液弁(Ｖ1)を閉じ、アルミブロック(Ｂ)の冷却流路(Ｐ)内に残った冷却液(Ｃ)を開放された排気弁(Ｖ4)或いは排液弁(Ｖ2)から排出する第一の制御機能と、液剤(Ｌ)を冷却するときに温度センサ(２)から送られた液剤(Ｌ)の温度が所定の閾値を下回ったところで圧縮エア(Ａ)の給気弁(Ｖ3)を閉じ、更に冷却液(Ｃ)の給液弁(Ｖ1)を開いて冷却流路(Ｐ)内を冷却液(Ｃ)で満たす第二の制御機能とを備えたことを特徴とする化学反応装置の加熱冷却機構。 A reaction tank (1) capable of containing a liquid agent (L) to be chemically reacted; a temperature sensor (2) for detecting the temperature of the liquid agent (L) in the reaction tank (1); and the reaction tank (1) A heater device (3) attached to the aluminum block (B) into which the liquid agent (L) in the reaction tank (1) can be heated via the aluminum block (B); ) And a cooling flow path (P) for allowing the cooling liquid (C) or compressed air (A) to pass therethrough; a circulation path (52) to the cooling flow path (P) of the aluminum block (B). A storage tank (51) connected via a circulation pump (53) for sending the coolant (C) into the cooling channel (P), and recovery from the cooling channel (P) A chiller unit (5) having a cooling means (54) for re-cooling the cooled coolant (C); and compressed air in the flow path connected to the cooling flow path (P) of the aluminum block (B). (A) can be supplied Air blow device (6); start-stop of the heater unit (3), and supply drain valve of the cooling liquid (C) (V 1) (V 2) and the compressed air supply and exhaust valves of the air (A) (V 3 ) And a control device (7) capable of controlling the opening and closing of (V 4 ),
The controller (7) closes the coolant (C) supply valve (V 1 ) in response to a start command to the heater device (3) when the liquid agent (L) is heated, and the aluminum block (B The first control function for discharging the cooling liquid (C) remaining in the cooling flow path (P) from the open exhaust valve (V 4 ) or drainage valve (V 2 ), and the liquid agent (L) When the temperature of the liquid agent (L) sent from the temperature sensor (2) falls below a predetermined threshold when cooling, the air supply valve (V 3 ) of the compressed air (A) is closed, and the coolant (C) A heating / cooling mechanism for a chemical reaction apparatus, comprising a second control function for opening the liquid supply valve (V 1 ) and filling the cooling flow path (P) with the cooling liquid (C).
前記制御装置(７)には、液剤(Ｌ)を加熱するときにヒーター装置(３)への始動命令に応じて冷却液(Ｃ)の給液弁(Ｖ1)を閉じ、ジャケット(４)内に残った冷却液(Ｃ)を開放された排気弁(Ｖ4)或いは排液弁(Ｖ2)から排出する第一の制御機能と、液剤(Ｌ)を冷却するときに温度センサ(２)から送られた液剤(Ｌ)の温度が所定の閾値を下回ったところで圧縮エア(Ａ)の給気弁(Ｖ3)を閉じ、冷却液(Ｃ)の給液弁(Ｖ1)を開いてジャケット(４)内を冷却液(Ｃ)で満たす第二の制御機能とを備えたことを特徴とする加熱冷却機能に優れた化学反応装置。 A reaction tank (1) capable of containing a liquid agent (L) to be chemically reacted; a temperature sensor (2) for detecting the temperature of the liquid agent (L) in the reaction tank (1); and the reaction tank (1) A heater device (3) for heating the liquid agent (L) therein; a space provided to cover the body of the reaction vessel (1) and capable of containing the coolant (C) therein And a supply / drain port (41) (42) to which a chiller unit (5) used for circulating supply of the coolant (C) can be connected, and an air blow device (6) used for supplying compressed air (A). A jacket (4) having a connectable air inlet (43); starting and stopping of the heater device (3), and a supply and discharge valve (V 1 ) (V 2 ) and compression of the coolant (C) while being configured to include an air supply and exhaust valves (a) (V 3) controllable control the opening and closing of (V 4) (7),
The controller (7) closes the coolant supply valve (V 1 ) in response to a start command to the heater device (3) when the liquid (L) is heated, and the jacket (4) A first control function for discharging the remaining coolant (C) from the opened exhaust valve (V 4 ) or drain valve (V 2 ), and a temperature sensor (2 ) When the temperature of the liquid agent (L) sent from the liquid drops below a predetermined threshold, the compressed air (A) supply valve (V 3 ) is closed and the cooling liquid (C) supply valve (V 1 ) is opened. And a second control function for filling the inside of the jacket (4) with the coolant (C).
前記制御装置(７)には、液剤(Ｌ)を加熱するときにヒーター装置(３)への始動命令に応じて冷却液(Ｃ)の給液弁(Ｖ1)を閉じ、アルミブロック(Ｂ)の冷却流路(Ｐ)内に残った冷却液(Ｃ)を開放された排気弁(Ｖ4)或いは排液弁(Ｖ2)から排出する第一の制御機能と、液剤(Ｌ)を冷却するときに温度センサ(２)から送られた液剤(Ｌ)の温度が所定の閾値を下回ったところで圧縮エア(Ａ)の給気弁(Ｖ3)を閉じ、更に冷却液(Ｃ)の給液弁(Ｖ1)を開いて冷却流路(Ｐ)内を冷却液(Ｃ)で満たす第二の制御機能とを備えたことを特徴とする加熱冷却機能に優れた化学反応装置。 A reaction tank (1) capable of containing a liquid agent (L) to be chemically reacted; a temperature sensor (2) for detecting the temperature of the liquid agent (L) in the reaction tank (1); and the reaction tank (1) And a heater device (3) capable of heating the liquid (L) in the reaction vessel (1) through the aluminum block (B); and the aluminum block (B) ) Is a through hole for allowing the coolant (C) or compressed air (A) to pass therethrough, and the chiller unit (5) used for circulating supply of the coolant (C) can be connected to the inlet / outlet of the through hole. A cooling flow path (P) having an air supply port (43) to which an air supply and discharge port (41) (42) and an air blowing device (6) used for supplying compressed air (A) can be connected; Controls the start / stop of the device (3) and the opening / closing of the supply / exhaust valves (V 1 ) (V 2 ) for the coolant (C) and the supply / exhaust valves (V 3 ) (V 4 ) for the compressed air (A) With possible control device (7) While that,
The controller (7) closes the coolant (C) supply valve (V 1 ) in response to a start command to the heater device (3) when the liquid agent (L) is heated, and the aluminum block (B The first control function for discharging the cooling liquid (C) remaining in the cooling flow path (P) from the open exhaust valve (V 4 ) or drainage valve (V 2 ), and the liquid agent (L) When the temperature of the liquid agent (L) sent from the temperature sensor (2) falls below a predetermined threshold when cooling, the air supply valve (V 3 ) of the compressed air (A) is closed, and the coolant (C) A chemical reaction apparatus excellent in heating and cooling function, comprising a second control function of opening the liquid supply valve (V 1 ) and filling the cooling flow path (P) with the cooling liquid (C).
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| CN109482122A (en) * | 2018-12-05 | 2019-03-19 | 威海天宇新材料科技有限公司 | Enamel electric heating reacting kettle |
| CN114522553A (en) * | 2022-02-28 | 2022-05-24 | 上海沪析实业有限公司 | Brushless motor shearing emulsifying machine capable of continuously working |
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| CN110743475A (en) * | 2019-11-14 | 2020-02-04 | 清远市番亿聚氨酯有限公司 | Polyurethane reaction kettle |
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| JPH03127625A (en) * | 1989-10-13 | 1991-05-30 | Tlv Co Ltd | Steam heating and vaporization cooling equipment |
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| CN114522553A (en) * | 2022-02-28 | 2022-05-24 | 上海沪析实业有限公司 | Brushless motor shearing emulsifying machine capable of continuously working |
| CN114522553B (en) * | 2022-02-28 | 2024-03-12 | 上海沪析实业有限公司 | Brushless motor shearing emulsifying machine capable of continuously working |
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