CN203743858U - On-line cooling device for injection water pipeline - Google Patents
On-line cooling device for injection water pipeline Download PDFInfo
- Publication number
- CN203743858U CN203743858U CN201420074167.8U CN201420074167U CN203743858U CN 203743858 U CN203743858 U CN 203743858U CN 201420074167 U CN201420074167 U CN 201420074167U CN 203743858 U CN203743858 U CN 203743858U
- Authority
- CN
- China
- Prior art keywords
- water
- injection
- pipeline
- controllable valve
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 86
- 238000001816 cooling Methods 0.000 title claims abstract description 27
- 238000002347 injection Methods 0.000 title abstract description 14
- 239000007924 injection Substances 0.000 title abstract description 14
- 239000008215 water for injection Substances 0.000 claims description 65
- 239000000498 cooling water Substances 0.000 claims description 10
- 238000012544 monitoring process Methods 0.000 claims description 2
- 238000012806 monitoring device Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000013019 agitation Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 102000010911 Enzyme Precursors Human genes 0.000 description 1
- 108010062466 Enzyme Precursors Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Abstract
The utility model provides an on-line cooling device for an injection water pipeline. Injection water can be cooled to be at the indoor temperature conveniently, and it is guaranteed that cooled injection water cannot flow back into a main pipeline. The on-line cooling device for the injection water pipeline comprises a set of parallel injection water pipelines which are connected into the injection water pipeline. The parallel injection water pipelines comprise the high temperature pipeline and the temperature control pipeline. The high temperature pipeline is connected into a first controllable valve capable of being opened and closed automatically, the temperature control pipeline is connected into a second controllable valve capable of being opened and closed automatically and a bypass with an outlet, and the temperature control pipeline is further provided with a heat exchange device used for cooling injection water and a temperature monitoring device capable of giving out electric signals. The bypass is connected into a third controllable valve capable of being opened and closed automatically. The heat exchange device is provided with an electromagnetic valve. The first controllable valve, the second controllable valve, the third controllable valve, the temperature monitoring device and the electromagnetic valve are all connected with a temperature control box, and the temperature control box can receive the electric signals sent out by the temperature monitoring device and control all the above components to be opened and closed.
Description
Technical field
The utility model relates to field of biological pharmacy, relates in particular to water for injection application, is specifically related to a kind of water for injection pipeline on-line cooling device.
Background technique
At present, domestic pharmacy corporation issues the requirement of " pharmaceutical production checking guide (2003) " according to State Food and Drug Administration, water for injection is required to following (selected parts): pipeline distribution system is necessary for circulation loop, and more than 80 DEG C insulation circulation, intrasystem " blind pipe " segment length must not be greater than the requirements such as 6 times of calibers.
According to afore mentioned rules, should be at 80 DEG C from the water for injection temperature that uses some valve to emit, if ingredients with medicine to thermo-responsive, need high temperature injection water to be cooled to the temperature of technological requirement, generally 50 DEG C of left and right, conventionally have two kinds of methods: the first is first discharged in Agitation Tank disposable the high temperature injection water of requirement, inject cooling water simultaneously toward Agitation Tank interlayer, the stirring apparatus of opening Agitation Tank is accelerated heat exchange.This method energy safety temperature is lowered, but waste the resources such as a large amount of power and waters, more need a large amount of time, for example, the waters for injection of 3 tons 80 DEG C are cooled to 50 DEG C with the cooling water (water temperature in summer being provided by cooling tower) of 32 DEG C, minimum needs 1 hour, are not suitable for continuous, a large amount of production.It two is mounting heat exchangers under U-shaped curved membrane valve, there are several points that need to use low-temperature injection water that several heat exchangers just need to be installed, this way can lower temperature rapidly, but pipeline, valve investment strengthen, and in cooling zone, seem very in disorder, easily cause operate miss.
When preparation accessory cleans, last procedure is to clean with water for injection, but from the foregoing, the temperature of water for injection in preparation and storage process, 80 DEG C of left and right, for convenience of using, need to cool to it.So needing to increase by one group of device on rising pipe comes pipeline to lower the temperature.
In addition, for energy-conservation object, cooling water for injection must not be back in main line, because cooling water for injection is back in main line, can affect water for injection temperature in supervisor.In addition, clearly specify at drug's GMP (production quality control procedure), water for injection stores and circulating temperature will be 80 DEG C of left and right, cooling water for injection must not be back in main line, because cooling water for injection is back in main line, can impact be responsible for interior water for injection temperature, not meet laws and regulations requirement.
In order to meet above two demands, in the urgent need to a kind of cooling unit.
Model utility content
For addressing the above problem, the purpose of this utility model is: a kind of water for injection pipeline on-line cooling device is provided, can be convenient to water for injection to be cooled to room temperature, and guarantee that cooling water for injection is not back in main line.
For achieving the above object, the scheme that the utility model is taked is:
A kind of water for injection pipeline on-line cooling device, comprising:
One group of water for injection pipeline in parallel of access water for injection pipeline, comprises a high temperature conduit and a temperature control pipeline;
The access of described high temperature conduit can automatic opening-closing one first controllable valve;
The access of described temperature control pipeline can have the bypass of outlet by automatic opening-closing one second controllable valve and, and is provided with a heat-exchange device of cooling water for injection and can sends a device for detecting temperature of electrical signal;
Described bypass access can automatic opening-closing 1 the 3rd controllable valve;
Described heat-exchange device has a solenoid valve;
Described the first controllable valve, the second controllable valve, the 3rd controllable valve, temperature monitoring and solenoid valve are all connected with a temperature control box;
Described temperature control box can receive the switching that temperature-detecting device sends electrical signal and can control the first controllable valve, the second controllable valve, the 3rd controllable valve and solenoid valve.
Further, described the first controllable valve, the second controllable valve and the 3rd controllable valve are all pneumatic valves.
Further, described temperature-detecting device is an electronic thermometer.
Further, described solenoid valve is a cooling electric magnet valve.
Further, described heat-exchange device is a cooler.
By taking said structure, need to use water for injection time, only need be by temperature control box switch opens, cooled water for injection can flow out from outlet.After finishing using, close temperature control box switch, cooler cuts out.Water for injection flows out from outlet, in line in pond.In the time of temperature recovery, the 3rd controllable valve is closed automatically, and the second controllable valve is opened automatically, and water for injection is back in high temperature conduit.Not only cooling convenience, it is convenient to control, and can effectively avoid cooling water for injection to flow into high temperature conduit and water for injection main line.
Brief description of the drawings
Fig. 1 is the utility model embodiment's structural representation
Reference character: 1-1 water for injection pneumatic valve 2-water for injection pipeline 3-2 water for injection pneumatic valve 4-3 water for injection pneumatic valve 5-electronic thermometer 6-outlet 7-temperature control box 8-cooling electric magnet valve 9-cooler.
Embodiment
For above-mentioned feature and advantage of the present utility model can be become apparent, special embodiment below, and coordinate institute's accompanying drawing to be described in detail below.
As shown in Figure 1, be applied to the water for injection pipeline on-line cooling device in injection recombinant human urokinase zymogen manufacture, in water for injection pipeline 2, access one group of water for injection pipeline in parallel, wherein one of pipeline in parallel is high temperature conduit, and what wherein circulate is the water for injection of 80 DEG C of left and right always.In addition be temperature control pipeline, wherein circulation water for injection be it to be cooled to below 37 DEG C by control.
Wherein, No. 1 water for injection pneumatic valve 1 of high temperature conduit access, can be controlled and be opened and closed by temperature control box 8.
Temperature control pipeline accesses successively as the cooler 9 of heat-exchange device, as the electronic thermometer 5 of device for detecting temperature, has bypass and No. 2 water for injection pneumatic valves 3 of No. 3 water for injection pneumatic valves 4 and outlet 6.
Cooler 9 is provided with the cooling electric magnet valve 8 of controlling its switch.
Temperature control box 8 can be controlled the switching of 3, No. 3 water for injection pneumatic valves 4 of No. 2 water for injection pneumatic valves and cooling electric magnet valve 8 equally, can accept the electrical signal that thermometer 5 sends simultaneously.
In the time that needs use this water for injection, only need be by temperature control box 7 switch opens, cooled water for injection is from exporting 6 outflows.
After finishing using, close the switch of temperature control box 7, cooler 9 cuts out.But now water temperature is lower than 80 DEG C, and water for injection flows out from outlet, in line in pond.In the time that temperature reaches 80 DEG C, No. 3 water for injection pneumatic valve 4 cuts out automatically, and No. 2 water for injection pneumatic valve 3 is opened automatically, and water for injection is back in main line.
Particularly, when temperature control box 7 switches cut out and water for injection temperature during lower than 80 DEG C, each point valve in state as following table:
| Legend code name | Title | State |
| 1 | No. 1 water for injection pneumatic valve | Open |
| 3 | No. 2 water for injection pneumatic valves | Close |
| 4 | No. 3 water for injection pneumatic valves | Open |
| 6 | Outlet | Water for injection flows out |
| 8 | Cooling electric magnet valve | Close |
| 9 | Cooler | Close |
When temperature control box 7 switches cut out and when water for injection temperature is more than or equal to 80 DEG C, each point valve in state as following table:
| Legend code name | Title | State |
| 1 | No. 1 water for injection pneumatic valve | Open |
| 3 | No. 2 water for injection pneumatic valves | Open |
| 4 | No. 3 water for injection pneumatic valves | Close |
| 6 | Outlet | Flow out without water for injection |
| 8 | Cooling electric magnet valve | Close |
| 9 | Cooler | Close |
In the time of temperature control box 7 switch open, each point valve in state as following table:
| Legend code name | Title | State |
| 1 | Water for injection pneumatic valve 1 | Close |
| 3 | Water for injection pneumatic valve 2 | Close |
| 4 | Water for injection pneumatic valve 3 | Open |
| 6 | Outlet | There is water for injection to flow out |
| 8 | Cooling electric magnet valve | Open |
| 9 | Cooler | Open |
Known by above-mentioned three tables, water for injection only cooling in temperature control loop and flow out for use, can't after use, flow in water for injection main line, in order to avoid affect the temperature in water for injection main line, not only reach the object that keeps temperature constant in water for injection main line.
Although the utility model is described as above with aforesaid embodiment, it can not be in order to limit the utility model.Those of ordinary skill under the utility model in technical field, not departing from spirit and scope of the present utility model, does a little change and modification, all in protection domain of the present utility model.Therefore protection domain of the present utility model when with claim the person of being defined be as the criterion.
Claims (5)
1. a water for injection pipeline on-line cooling device, is characterized in that, comprising:
One group of water for injection pipeline in parallel of access water for injection pipeline, comprises a high temperature conduit and a temperature control pipeline;
The access of described high temperature conduit can automatic opening-closing one first controllable valve;
The access of described temperature control pipeline can have the bypass of outlet by automatic opening-closing one second controllable valve and, and is provided with a heat-exchange device of cooling water for injection and can sends a device for detecting temperature of electrical signal;
Described bypass access can automatic opening-closing 1 the 3rd controllable valve;
Described heat-exchange device has a solenoid valve;
Described the first controllable valve, the second controllable valve, the 3rd controllable valve, temperature monitoring and solenoid valve are all connected with a temperature control box;
Described temperature control box can receive the switching that temperature-detecting device sends electrical signal and can control the first controllable valve, the second controllable valve, the 3rd controllable valve and solenoid valve.
2. water for injection pipeline on-line cooling device according to claim 1, is characterized in that, described the first controllable valve, the second controllable valve and the 3rd controllable valve are all pneumatic valves.
3. water for injection pipeline on-line cooling device according to claim 1, is characterized in that, described temperature-detecting device is an electronic thermometer.
4. water for injection pipeline on-line cooling device according to claim 1, is characterized in that, described solenoid valve is a cooling electric magnet valve.
5. water for injection pipeline on-line cooling device according to claim 1, is characterized in that, described heat-exchange device is a cooler.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420074167.8U CN203743858U (en) | 2014-02-20 | 2014-02-20 | On-line cooling device for injection water pipeline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420074167.8U CN203743858U (en) | 2014-02-20 | 2014-02-20 | On-line cooling device for injection water pipeline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203743858U true CN203743858U (en) | 2014-07-30 |
Family
ID=51343659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420074167.8U Expired - Lifetime CN203743858U (en) | 2014-02-20 | 2014-02-20 | On-line cooling device for injection water pipeline |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203743858U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107490984A (en) * | 2016-06-12 | 2017-12-19 | 上海奥星制药技术装备有限公司 | Colod-application control cabinet of water for injection |
| CN112503396A (en) * | 2020-11-05 | 2021-03-16 | 扬子江药业集团广州海瑞药业有限公司 | Cooling injection water drainage control method and system |
-
2014
- 2014-02-20 CN CN201420074167.8U patent/CN203743858U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107490984A (en) * | 2016-06-12 | 2017-12-19 | 上海奥星制药技术装备有限公司 | Colod-application control cabinet of water for injection |
| CN107490984B (en) * | 2016-06-12 | 2023-05-16 | 上海奥星制药技术装备有限公司 | Water-cooling point control box for injection |
| CN112503396A (en) * | 2020-11-05 | 2021-03-16 | 扬子江药业集团广州海瑞药业有限公司 | Cooling injection water drainage control method and system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: No. 1 and No. 2, 280 Curie Road, China (Shanghai) Free Trade Pilot Area, Shanghai, 2003 Patentee after: TASLY PHARMACEUTICAL GROUP Co.,Ltd. Address before: 201203 No. 280 Curie Road, Zhangjiang High-tech Park, Pudong New Area, Shanghai Patentee before: SHANGHAI TASLY PHARMACEUTICAL Co.,Ltd. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140730 |