JP2012135635A - Bioinformation measurement device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To eliminate trouble of applying or sticking on a part to be measured, or work for wiping off an adhering substance of the part to be measured, and to simplify the handling to allow measurement on the same conditions.SOLUTION: This bioinformation measurement device includes: a measurement part for noninvasively measuring a substance inside a test subject based on light irradiating the test subject with light; a strip-like coupling tape, interposed between the test subject and the measurement part, for coupling the test subject and the measurement part; and a carrying mechanism for carrying the coupling tape. The coupling tape has: a sheet body formed in a strip shape; and coupling sheets, provided on the sheet body at prescribed interval, and transmitting light irradiated from the measurement part and the light from the test subject.

Description

  The present invention relates to a biological information measuring apparatus that non-invasively measures a component or concentration of a substance present in a subject such as a living body, or physical property information of a living tissue, and is used for improving the measurement accuracy of biological information. The present invention relates to a biological information measuring apparatus with a specimen.

  For example, non-invasive measurement of the concentration of substances in blood, biological tissue cells, or body fluids outside biological tissue cells, and optical properties of biological tissues for health management, diagnosis and treatment of diseases, or beauty. A biological information measuring device is used. This biological information measuring apparatus irradiates a subject such as a living body with light such as visible light, near-infrared light, mid-infrared light, or far-infrared light, receives light transmitted, reflected, or scattered inside the living body, and enters the living body. Measure the concentration of the components of existing biological materials. A biological information measurement apparatus using such light changes the state of the measurement target part by changing the temperature of the measurement target part in the subject, and measures biological information based on the change in optical intensity due to this change. To do.

  Concentrations of biological substances to be measured include protein components such as glucose, cholesterol, neutral fat and albumin, blood component concentrations such as hemoglobin and creatinine, in-vivo gas concentrations such as oxygen and carbon dioxide, alcohols and drugs And so on. In addition, the biological information measuring apparatus also measures non-invasively information related to degeneration of biological information represented by cancer, inflammation, skin moisturizing ability, arteriosclerosis and the like.

  Such a biological information measuring device is disclosed in Patent Document 1, for example. This Patent Document 1 is a technique for noninvasively measuring glucose levels in blood using near-infrared light. The wrist-elbow part is placed on a pad, and the skin surface from the wrist to the elbow part. And measuring the glucose level by directly contacting the sensor.

  In the measurement of biological information, for example, in order to obtain biological information effectively based on light transmitted through the living body, it is necessary to irradiate the living body with light with high efficiency and receive light from the living body. For this purpose, a coupling member is arranged between the measurement part and the measurement part in the subject to enhance the optical characteristics and thermal conductivity between the measurement part and the measurement part. As the coupling member, there are a type that is applied to the measurement target part and a seal type that is attached to the measurement target part.

  These coupling members must be carried separately from the biological information measuring apparatus for both the application type and the seal type. In addition, when performing measurement, the type of coupling member to be applied must be applied to the measurement portion of the subject, and the seal-type coupling member is attached to the measurement portion of the subject. Work has to be done and both types are laborious.

  Since the coupling member is applied to or pasted on the measurement target portion, for example, the measurement target portion may be contaminated by a substance attached when the coupling member is applied to or attached to the measurement target portion. If the measurement is performed while the measurement target is dirty, the light that is transmitted, reflected, or scattered according to the biological substance by the substance attached to the measurement target is further scattered. For this reason, the precision of a measurement result will fall. In order to prevent a decrease in the accuracy of the measurement result, it is necessary to perform an operation of wiping off the substance attached to the measurement target part.

  It is difficult to apply or affix the coupling member to the measurement target part under the same conditions for both the application type and the seal type.

US Pat. No. 6,088,605

  An object of the present invention is to provide an easy-to-handle biological information measuring apparatus that eliminates the trouble of applying or pasting to a measurement target part and the operation of wiping off the adhered substance on the measurement target part and enables measurement under the same conditions. It is in.

  The biological information measuring apparatus according to the first aspect of the present invention is a measurement unit that non-invasively measures a substance in the subject based on light from the subject when the subject is irradiated with light. And a strip-shaped coupling tape that is interposed between the subject and the measurement unit and couples between the subject and the measurement unit, and a transport mechanism that transports the coupling tape. The coupling tape includes a sheet main body formed in a strip shape, a coupling sheet that is provided in the sheet main body at predetermined intervals and transmits light emitted from the measurement unit and light from the subject. Have

  The biological information measuring apparatus according to the second aspect of the present invention is a measuring unit that non-invasively measures a substance in the subject based on light from the subject when the subject is irradiated with light. And a sheet main body formed in a belt shape, and a coupling sheet that is provided in the sheet main body at predetermined intervals and transmits light emitted from the measurement unit and light from the subject, A transport mechanism that transports a strip-shaped coupling tape that is interposed between the subject and the measurement unit and couples between the subject and the measurement unit.

  According to the present invention, it is possible to provide an easy-to-handle biological information measuring apparatus that eliminates the trouble of applying or pasting to a measurement target part and the operation of wiping off the adhered substance on the measurement target part and enables measurement under the same conditions.

The internal structure figure which shows 1st Embodiment of the biological information measuring device which concerns on this invention. Functional block diagram of the apparatus. The figure which shows the periphery structure of the coupling tape and measurement part in the same apparatus. The specific cross-section block diagram of the peelable coupling tape in the apparatus. The top view of the coupling sheet | seat in the same apparatus. The plane block diagram of the coupling sheet | seat in the same apparatus. The specific block diagram of the adhesion part in the apparatus. The figure which shows arrangement | positioning of the coupling sheet | seat at the time of the measurement in the same apparatus. The figure which shows the affixing to the subject of the coupling sheet by the raise of the measurement part in the same apparatus. The figure which shows the state which affixed the coupling sheet in the same apparatus on the subject. The figure which shows the sliding movement of the coupling tape in the apparatus. The figure which shows the coupling | bonding of the subject and measurement part via the coupling sheet in the same apparatus. The figure which shows the return to the original position of the measurement part after the measurement completion in the same apparatus. The figure which shows the cleaning state of the measurement part by the cleaning sheet in the apparatus. The figure which shows arrangement | positioning of the coupling sheet | seat at the time of the next measurement in the same apparatus. The block diagram which shows the modification of the peeling mechanism in the apparatus. The specific cross-section block diagram which shows 2nd Embodiment of the integral coupling tape in the biological information measuring device which concerns on this invention. The top view of the coupling sheet | seat in the same apparatus. The plane block diagram of the coupling sheet | seat in the same apparatus. The specific block diagram of the adhesion part in the apparatus. The internal structure figure of the apparatus. The figure which shows the periphery structure of the coupling tape and measurement part in the same apparatus. The figure which shows arrangement | positioning of the coupling sheet | seat at the time of the measurement in the same apparatus. The figure which shows the affixing to the subject of the coupling sheet by the raise of the measurement part in the same apparatus. The figure which shows the cleaning state of the measurement part by the cleaning sheet in the apparatus. The figure which shows arrangement | positioning of the coupling sheet | seat at the time of the next measurement in the same apparatus. The figure which shows confrontation of the coupling sheet | seat and measurement part at the time of the measurement in the same apparatus. The figure which shows the affixing to the subject of the coupling sheet by the raise of the measurement part in the same apparatus. The figure which shows the silicon resin etc. which adhered to the upper surface of the measurement part in the same apparatus. The figure which shows the facing state of the cleaning sheet and measurement part in the apparatus. The figure which shows the cleaning state of the measurement part by the cleaning sheet in the apparatus. The figure which shows the cleaning state of the measurement part by the cleaning sheet in the apparatus. The figure which shows arrangement | positioning of the coupling sheet | seat at the time of the next measurement in the same apparatus. The figure which shows the state of the door open | release at the time of tape feeding of the coupling tape case in the apparatus. The figure which shows the state of a door closing at the time of the tape feed stop of the coupling tape case in the apparatus.

Hereinafter, a first embodiment of the present invention will be described with reference to the drawings.
FIG. 1 shows an internal structure diagram of the biological information measuring apparatus, and FIG. 2 shows a functional block diagram. A holder portion 2 formed in a U shape is provided on the upper surface of the apparatus housing 1. On the holder part 2, for example, a human arm as a subject is placed. The holder portion 2 is formed in a U shape that matches the shape of the human arm.
A measurement unit 3 is provided inside the apparatus housing 1. The measurement unit 3 noninvasively measures a substance in the human arm based on light from the human arm when the subject H is irradiated with light on the human arm, for example. The measurement unit 3 is provided below the measurement window 4 provided in the holder unit 2.

  A coupling tape case 5 and a collection case 6 are provided inside the apparatus housing 1. The coupling tape case 5 and the collection case 6 are provided on both sides of the measuring unit 3, respectively. In this coupling tape case 5, a wound coupling tape 7 is rotatably supported on a shaft 8. The coupling tape case 5 can be attached to and detached from the inside of the apparatus housing 1. The coupling tape case 5 is configured with high confidentiality, and maintains the humidity in the case 5. Thereby, the chemical component for cleaning of the measuring unit 3 included in the coupling tape 7 does not evaporate.

The collection case 6 is supplied from the coupling tape 7 above the measuring unit 3 and collects the coupling tape 7 used for measurement. Specifically, the collection case 6 is provided with a rotatable shaft 9. The tip of the coupling tape 7 is locked to the shaft 9. The shaft 9 is connected to a drive unit 9a having a motor or the like. The drive unit 9a is driven for a predetermined period when the coupling tape 7 is collected. As a result, when the shaft 9 is rotated by the drive of the drive unit 9a, the coupling tape 7 is wound around the shaft 9, and the coupling tape 7 is conveyed by a predetermined distance in the direction of the arrow A.
Therefore, the coupling tape case 5 and the recovery case 6 serve as a transport mechanism for the coupling tape 7, the coupling tape case 5 side is the upstream side of the transport of the coupling tape 7, and the recovery case 6 side is the coupling. It is the downstream side of the conveyance of the tape 7.

The measurement unit 3 includes a light source unit 10 as shown in FIG. The light source unit 10 outputs monochromatic light having a desired wavelength, a plurality of monochromatic lights having different wavelengths, or light having a wavelength close to these monochromatic lights. The light source unit 10 uses a small light emitting element such as a semiconductor laser (LD) or a light emitting diode (LED). The light source unit 10 uses one or a plurality of light emitting elements such as LDs or LEDs that output light of a desired wavelength.
The multiplexing unit 11 superimposes monochromatic light of each wavelength of light output from the light source unit 10 on the same optical axis. The irradiation / light receiving unit 12 irradiates the measurement target portion of the subject H such as a human arm via the interface unit 13 with the light having the monochromatic light of each wavelength superimposed on the same optical axis by the multiplexing unit 11. In addition, the optical axis of each light for simultaneously receiving each light diffused, transmitted or reflected from the measurement target portion of the subject H is controlled. The interface unit 13 irradiates the subject H with light from the irradiation / light receiving unit 12, and guides the diffused, transmitted, or reflected light from the subject H to the light detection unit 14. A coupling tape 7 is interposed between the interface unit 13 and the subject H.

  The light detection unit 14 simultaneously receives each optical signal diffused, transmitted, or reflected from the measurement unit of the subject H whose optical axes are controlled by the irradiation / light reception unit 12, and each of these optical signals is an analog electrical signal. It converts into each detection signal which is. The intensity of each light diffused, transmitted or reflected through the subject H depends on the abundance ratio or concentration of a predetermined substance existing in the subject H, for example, glucose. Therefore, the level of each detection signal output from the light detection unit 14 depends on the abundance ratio and concentration of a predetermined substance present in the subject H. The signal amplification unit 15 amplifies each detection signal output from the light detection unit 14 to a desired amplitude.

  A temperature controller 16 and a temperature sensor 17 are provided in the apparatus housing 1. The temperature control unit 16 and the temperature sensor 17 are provided in the vicinity of the measurement unit 3, for example, in the vicinity of the measurement unit of the subject H. The temperature control unit 16 receives the temperature measurement signal output from the temperature sensor 17 and feedback-controls the temperature of the measurement target portion of the subject H to a predetermined temperature set in advance. The temperature control unit 16 is formed by using, for example, a metal material such as aluminum having good thermal conductivity as a thermal interface unit with the subject H, and a Peltier element serving as a heat source is attached to the bottom surface of the thermal interface unit. The temperature sensor 17 measures the temperature of the measurement target portion of the subject H and outputs the temperature measurement signal. The temperature sensor 17 is composed of, for example, a thermocouple or a thermistor and is embedded in a thermal interface unit with the subject H.

A display unit 19, an operation unit 20, a data storage unit 21, a data collection unit 22, and a signal processing unit 23 are connected to the control unit 18. The control unit 18 includes a CPU that constitutes a computer, issues a display command to the display unit 19, receives an operation instruction from the operation unit 20, writes data to and reads data from the data storage unit 21, Each processing command is issued to the data collection unit 22 and the signal processing unit 23.
The display unit 19 is composed of, for example, a liquid crystal display device, and displays, for example, a substance in the body of the subject H, such as a measurement result of glucose concentration, on the display screen.
The operation unit 20 functions as an information input unit using, for example, a man-machine interface, and includes, for example, a keyboard, a mouse, a button, or a touch key panel.
The data collection unit 22 converts each detection signal amplified to a desired amplitude by the signal amplification unit 15 into a digital signal and collects it as measurement data.
The signal processing unit 23 processes each measurement data collected by the data collecting unit 22 and information on the component and concentration of the substance present in the subject H or the tissue degeneration of the subject H, for example, the subject H The glucose concentration in the body is calculated, and the glucose concentration and the like are stored in the data storage unit 21 as necessary.

The control unit 18 includes a display unit 19, a power supply unit 24, a light source unit 10, a signal amplification unit 15, a temperature control unit 16, a data storage unit 21, a data collection unit 22, signal processing based on an operation signal from the operation unit 20. The operation of the unit 23 and the like is controlled. The control unit 18 supplies power to the temperature control unit 16, the data storage unit 21, the signal processing unit 23, and the like as necessary. The power supply unit 24 supplies power to the display unit 19, the light source unit 10, the signal amplification unit 15, the control unit 18, and the like.
FIG. 3 shows a peripheral configuration of the peelable coupling tape 7 and the measuring unit 3, and FIG. 4 shows a specific cross-sectional structure of the peelable coupling tape 7. The coupling tape 7 includes a strip-shaped protective sheet 30 as a sheet body, a plurality of coupling sheets 31 provided on the upper surface of the protective sheet 30, and a strip-shaped release sheet provided on the coupling sheet 31. 32 and a belt-like cleaning sheet 33 provided on the lower surface of the protective sheet 30.
The protection sheet 30 is formed in a band shape. The protective sheet 30 transmits monochromatic light having a desired wavelength output from the light source unit 10, a plurality of monochromatic lights having different wavelengths, or light having a wavelength close to these monochromatic lights.

  The plurality of coupling sheets 31 are provided on the upper surface of the protective sheet 30 at predetermined intervals. These coupling sheets 31 couple between the measurement unit 3 and the subject H. FIG. 5 shows a top view of the coupling sheet 31. These coupling sheets 31 are formed in an elliptical shape, for example. These coupling sheets 31 are provided to be peelable from the protective sheet 30. These coupling sheets 31 are light transmissive and have high thermal conductivity, and include, for example, glassine paper coated with silicon.

  FIG. 6 shows a specific configuration of the coupling sheet 31. Each of the coupling sheets 31 includes a light transmission part 34 and an adhesive part 35 that are formed in an elliptical shape. The light transmitting portion 34 and the bonding portion 35 are provided in a concentric shape with the light transmitting portion 34 as an inner side and the bonding portion 35 as an outer side. The light transmission unit 34 transmits the light emitted from the measurement unit 3 and the light from the subject H. The light transmission part 34 is made of, for example, a silicon resin such as silicon rubber. For example, the light transmitting portion 34 transmits light having a wavelength of 400 to 2500 nm and has a refractive index of 1.38 to 1.50. The light transmission part 34 has a thermal conductivity of 1.0 Mw / cm / ° C. or higher at a temperature of 10 to 45 ° C.

  The adhesion part 35 adheres to the subject H. The bonding portion 35 is made of, for example, an acrylic adhesive emulsion. As shown in FIG. 7, the bonding portion 35 includes a first layer bonding portion 35a and a second layer bonding portion 35b. The first layer bonding portion 35 a is bonded to the upper surface of the protective sheet 30. The first layer adhesive portion 35a has a lower degree of adhesion than the second layer adhesive portion 35b. However, the first layer bonding portion 35a is lightly bonded to, for example, the upper surface of the protective sheet 30, and has a degree of adhesion that peels off from the upper surface of the protective sheet 30 when the second layer bonding portion 35b is bonded to the subject H. The second layer bonding portion 35b can be peeled off from the release sheet 32 and adheres to the subject H with a predetermined strength. Thereby, the adhesive part 35 has the highest adhesive strength with the subject H, and then decreases in the order of the adhesive strength with the protective sheet 30 and then the adhesive strength with the release sheet 32. Have

The release sheet 32 is provided on the upper surface of each coupling sheet 31 and protects the coupling sheet 31. The release sheet 32 is peeled off from the coupling sheet 31 immediately before the coupling sheet 31 is attached to the subject H.
The cleaning sheet 33 is provided on the lower surface of the protective sheet 30, that is, on the side facing the measuring unit 3. The cleaning sheet 33 is in contact with the upper surface of the measuring unit 3 at a constant pressure, and removes deposits on the upper surface of the measuring unit 3 by friction when moving while rubbing the upper surface of the measuring unit 3. That is, the cleaning sheet 33 is conveyed toward the collection case 6 together with the coupling tape 7. At this time, the cleaning sheet 33 moves in contact with the measurement unit 3 at a constant pressure, thereby generating friction with the measurement unit 3. The friction removes deposits on the upper surface of the measurement unit 3. The cleaning sheet 33 is made of, for example, a fiber material. The cleaning sheet 33 includes a chemical component that cleans the measuring unit 3, such as ethanol.

  A vertical mechanism 40 is provided in the measurement unit 3. The up-and-down mechanism 40 moves the measuring unit 3 in the direction of the arrow B when the substance H in the human arm, for example, is measured non-invasively as the subject H, and the measuring unit 3 is coupled via the coupling tape 7. Close contact with human arm. When the measurement is finished, the vertical mechanism 40 returns to the original position.

  An armrest 41 is provided around the measurement window 4. A subject H is placed on the armrest 41. On the supply side of the coupling tape 7 in the armrest 41, a peeling introduction member 42 and a peeling roller 43 as a peeling mechanism are provided. A passage for collecting the release sheet 32 is formed between the release introduction member 42 and the armrest 41. A peeling roller 43 is provided at the leading end of the peeling introduction member 42 on the measurement window 4 side. Accordingly, the release sheet 32 is hung on the release roller 43 and set in the collection path. As a result, the release sheet 32 is guided into the collection passage through the release roller 43 along with the conveyance of the coupling tape 7 in the arrow A direction, and is released from the top of each coupling sheet 31.

A slide mechanism 44 is provided in the coupling tape case 5 and the collection case 6. The slide mechanism 44 slides the coupling tape case 5 and the collection case 6 together in the direction of the arrow C within the apparatus housing 1, and retracts the coupling tape 7 from the position above the measuring unit 3. The direction C of the slide movement is, for example, a direction orthogonal to the direction of the arrow A that transports the coupling tape 7.
The control unit 18 controls driving of the driving unit 9a and the slide mechanism 44.

  Next, a measurement operation using the peelable coupling tape 7 will be described with reference to FIGS. 8A to 15A are top views, and FIGS. 8B to 15B are side views. Moreover, in the same figure, the several coupling sheet | seat 31 is shown as coupling sheet | seat 31-1, 31-2, 31-3 on the degree of description.

  First, the coupling tape case 5 and the collection case 6 are each attached to the inside of the apparatus housing 1. The coupling tape 7 housed in the coupling tape case 5 is pulled out from the coupling tape case 5 at the tip, and is locked to the shaft 9 of the collection case 6 via the upper part of the measuring unit 3. . Further, the front end portion of the release sheet 32 is peeled off from each coupling sheet 31, hung on a peeling roller 43, and set in a collection passage.

  Next, a subject H such as a human arm is placed on the holder part 2 formed in a U-shape. In this state, the control unit 18 drives the drive unit 9 a to rotate the shaft 9 to wind the coupling tape 7 around the shaft 9, and the coupling tape 7 is wound along with the winding of the coupling tape 7. 7 is conveyed in the direction of arrow A. Along with the conveyance of the coupling tape 7, the release sheet 32 is guided into the collection passage through the release roller 43 and is released from the coupling sheet 31. The peeled release sheet 32 is collected.

  As shown in FIG. 8A, one coupling sheet 31-1 immediately after the release sheet 32 is peeled off by the conveyance of the coupling tape 7 is below the measurement window 4 and substantially at the center of the measurement window 4. Then, the control unit 18 stops driving the drive unit 9a and stops the conveyance of the coupling tape 7. At this time, the coupling sheet 31-2 on the downstream side of the coupling sheet 31-1 from which the release sheet 32 has been peeled is present on the upstream side of the peeling roller 43 as shown in FIG. Is not peeled. In addition, the stop control of the conveyance of the coupling tape 7 may be stopped by a manual instruction to the control unit 18, or the coupling sheet 31 is conveyed below the measurement window 4 and substantially at the center of the measurement window 4. It may be automatically stopped when it is detected.

  Next, the vertical mechanism 40 raises the measuring unit 3 by a predetermined distance in the direction of arrow B as shown in FIG. As the measurement unit 3 moves up, the measurement unit 3 pushes up the coupling tape 7 and presses the coupling tape 7 onto the arm or the like of the human body that is the subject H. As a result, the coupling sheet 31-1 on the coupling tape 7 adheres to the subject H by the adhesive portion 35. The rising distance of the measuring unit 3 is, for example, the distance between the upper surface of the measuring unit 3 and the cleaning sheet 33 before the measuring unit 3 moves upward, and the coupling sheet 31-1 from the cleaning sheet 33 in the coupling tape 7. And the distance between the upper surface of the coupling sheet 31-1 and the measurement window 4 and the ascending distance for pressing the coupling sheet 31-1 to the subject H with a predetermined pressure. It is determined.

  Next, the vertical mechanism 40 lowers the measuring unit 3 in the arrow B direction and returns it to the original position as shown in FIG. As a result, the coupling tape 7 also descends as the measuring unit 3 descends. At this time, since the first layer adhesive portion 35a in the coupling sheet 31-1 has a lower adhesiveness than the adhesiveness of the second layer adhesive portion 35b, the coupling sheet 31-1 adhered to the subject H. It peels from the protective sheet 30 as it is.

Next, as shown in FIGS. 11A and 11B, the slide mechanism 44 slides the coupling tape case 5 and the collection case 6 together in the direction of the arrow C within the apparatus housing 1 to perform coupling. The tape 7 is retracted from the upper position of the measuring unit 3. Thereby, the upper surface of the measurement unit 3 directly faces the subject H through the measurement window 4.
Next, the vertical mechanism 40 raises the measuring unit 3 by a predetermined distance in the arrow B direction as shown in FIG. The measuring unit 3 comes into contact with the coupling sheet 31-1 by being lifted, and pushes up the coupling sheet 31-1 and presses it against the subject H. By this pressing, the coupling sheet 31-1 on the coupling tape 7 adheres to the subject H. As a result, the measurement unit 3 is coupled to the subject H via the coupling sheet 31-1. Thereby, the optical characteristic and thermal conductivity between the measurement part 3 and the subject H are improved. Note that the ascending distance of the measuring unit 3 is, for example, the distance between the upper surface of the measuring unit 3 and the measuring window 4 before the measuring unit 3 moves upward, and the coupling sheet 31-1 with the subject H at a predetermined pressure. It is determined by adding the rising distance for pressure bonding.

  In this state, the measurement unit 3 irradiates the subject H with light via the coupling sheet 31-1, and non-invasively disposes the substance in the subject H based on the light from the subject H at this time. To measure. That is, the light source unit 7 outputs monochromatic light having a desired wavelength, a plurality of monochromatic lights having different wavelengths, or light having a wavelength close to these monochromatic lights. This light enters the multiplexing unit 8 and monochromatic light of each wavelength is superimposed on the same optical axis. The light emitted from the multiplexer 8 is irradiated to the subject H by the irradiation / light receiving unit 9 via the interface unit 10. At this time, the light beams diffused, transmitted or reflected by the subject H are simultaneously received by the light detection unit 11 by the irradiation / light reception unit 9, so that the optical axis of each light is controlled.

  The light detection unit 11 simultaneously receives each light diffused, transmitted, or reflected from a desired site or a plurality of measurement sites of the subject H whose optical axes are controlled by the irradiation / light reception unit 9 and receives these lights. Each detection signal is an analog electrical signal. At this time, the intensity of each optical signal diffused, transmitted or reflected through the subject H depends on the abundance ratio or concentration of a predetermined substance, for example, glucose present in the subject H.

Therefore, the level of each detection signal output from the light detection unit 11 depends on the abundance ratio and concentration of a predetermined substance present in the subject H. The signal amplification unit 12 amplifies each detection signal output from the light detection unit 11 to a desired amplitude. The data collection unit 17 converts each detection signal amplified to a desired amplitude by the signal amplification unit 12 into a digital signal and collects it as each measurement data. The collected measurement data is stored in the data storage unit 16 together with time information at the time of measurement by the control unit 15. Thereby, the measurement of the substance in the subject H is completed. At the time of non-invasive measurement, the temperature control unit 13 inputs a temperature measurement signal output from the temperature sensor 14 and feedback-controls the temperature of a desired part or a plurality of parts to be measured of the subject H to a predetermined temperature. .
When the non-invasive measurement of the substance in the subject H is completed, the vertical mechanism 40 lowers the measuring unit 3 in the arrow B direction and returns it to the original position as shown in FIG. At this time, the 1st layer adhesion part 35a in the coupling sheet 31-1 has an adhesiveness lower than the adhesiveness of the 2nd layer adhesion part 35b. As a result, the coupling sheet 31-1 leaves the upper surface of the measurement unit 3 while adhering to the subject H. In this state, the subject H such as a human arm is removed from the holder unit 2.

  Next, as shown in FIGS. 14A and 14B, the slide mechanism 44 slides the coupling tape case 5 and the recovery case 6 together in the direction of the arrow C within the apparatus housing 1 to perform coupling. The tape 7 is returned to the upper position of the measuring unit 3. Thereby, the coupling tape 7 is disposed on the upper surface of the measuring unit 3, and the cleaning sheet 33 contacts the upper surface of the measuring unit 3. And in this state, it waits until the next measurement.

  At the time of the next measurement, the control unit 18 drives the drive unit 9a for a predetermined period, rotates the shaft 9 and winds the coupling tape 7 around the shaft 9, and with the winding of the coupling tape 7 Then, the coupling tape 7 is conveyed in the direction of arrow A. The transport distance of the coupling tape 7 at this time is set to be the same as the arrangement interval of the coupling sheets 31-1 and 31-2. In the same manner as described above, the release sheet 32 is guided to the collection passage through the release roller 43 and is peeled off from the coupling sheet 31-2 by the transport of the coupling tape 7. The The peeled release sheet 32 is collected.

  As the coupling tape 7 is transported, the cleaning sheet 33 is brought into contact with the upper surface of the measuring unit 3 at a constant pressure as shown in FIG. For example, a silicon resin such as silicon rubber which forms the light transmitting portion 34 of the coupling sheet 31-1 is wiped off. Since the cleaning sheet 33 contains a chemical component such as ethanol, the cleaning sheet 33 is wiped off without leaving any deposits on the upper surface of the measuring unit 3.

As shown in FIGS. 15A and 15B, the next coupling sheet 31-2 from which the release sheet 32 has been peeled is conveyed below the measurement window 4 and substantially at the center of the measurement window 4 as the coupling tape 7 is conveyed. Then, the control unit 18 stops driving the drive unit 9a and stops the conveyance of the coupling tape 7.
Thereafter, the substance in the subject H is measured in the same manner as described above.

  As described above, according to the first embodiment, the plurality of coupling sheets 31 are provided on the protective sheet 30, the release sheet 32 is provided on the coupling sheet 31, and the cleaning sheet is provided on the lower surface of the protective sheet 30. 33 is provided to form a peeling-type coupling tape 7 and when the substance information in the subject H is measured, the coupling tape 7 is automatically conveyed, and the peeling sheet 32 is peeled along with this conveyance. Then, the measuring unit 3 is coupled to the subject H via the coupling tape 7. Each coupling sheet 31 is uniform in size, thickness, and the like, and can be made substantially the same position to be attached to the subject H. However, it is possible to improve the reproducibility of the state when measuring the substance information in the subject H by coupling the measuring unit 3 to the subject H via the coupling tape 7, and in the subject H under the same conditions. Non-invasive measurement of substances is possible.

  At the time of non-invasive measurement of the substance in the subject H, the coupling sheet 31 is sandwiched between the subject H and the measurement unit 3, so that reflection on the skin surface of the subject H such as a human arm is performed. Light can be suppressed, and light can be efficiently irradiated into the subject H such as a human arm.

  The coupling sheet 31 is peeled off immediately after the non-invasive measurement of the substance in the subject H is started and is in close contact with the subject H. The coupling sheet 31 is connected to the measuring unit 3 via the coupling sheet 31. Since the coupling with the subject H is performed, dust or the like adheres to the coupling sheet 31 and the measurement unit 3 and the subject H are not contaminated by the attached matter. Further, along with the conveyance of the coupling tape 7, the cleaning sheet 33 can be wiped without leaving any deposits on the upper surface of the measuring unit 3. Thereby, the transmitted light, reflected light, and scattered light according to the biological material information in the subject H can be received, and the accuracy of the measurement result can be maintained high. The work of wiping off the substance adhering to the upper surface of the measuring unit 3 is also eliminated.

  Since the attachment of the coupling sheet 31 to the subject H is automatically performed by the ascending of the measurement unit 3, for example, it is possible to eliminate the time and labor of attaching by the manual operation of the operator. Since the coupling tape 7 is attached in the apparatus housing 1, the coupling tape 7 is not carried separately from the apparatus housing 1.

  Since the coupling tape 7 after the coupling sheet 31 is used for measurement, that is, the protective sheet 30 and the cleaning sheet 33 are collected in the collection case 6, protection after using the entire coupling sheet 31. The sheet 30 and the cleaning sheet 33 can be discarded together. Similarly, the release sheet 32 can be recovered and discarded.

  Note that the peeling mechanism for peeling the release sheet 32 may be configured as shown in FIG. The measuring unit 3 is in a raised state. Lower surface side tape guides 50 and 51 are rotatably provided on the lower surface side of the coupling tape 7. The lower surface side tape guides 50 and 51 are provided at substantially the same height as the height position of the upper surface of the measuring unit 3 at the rising position of the measuring unit 3.

  A pair of upper surface side tape guides 52 and 53 are rotatably provided on the upstream side of the conveyance of the coupling tape 7 in the measuring unit 3 and on the upper surface side of the release sheet 32. These upper surface side tape guides 52, 53 rotate while sandwiching the release sheet 32 to release the release sheet 32 from the coupling tape 7. The peeled release sheet 32 can be collected and discarded in the same manner as described above.

  A recovery tape guide 54 is provided on the downstream side of the conveyance of the coupling tape 7 in the measurement unit 3 and on the upper surface side of the release sheet 32. The collection tape guide 54 sends the coupling tape 7 using the coupling sheet 31 to, for example, the collection case 6.

Next, a second embodiment of the present invention will be described with reference to the drawings.
FIG. 17 shows a specific cross-sectional configuration of the integrated coupling tape 60. The coupling tape 60 is sandwiched between a belt-shaped protective sheet 61 as a sheet body, a belt-shaped cleaning sheet 62 provided on the lower surface of the protective sheet 61, and the protective sheet 61 and the cleaning sheet 62. It comprises a plurality of coupling sheets 63 and a strip-like release sheet 64 provided on the upper surface of the protective sheet 30.

The protective sheet 61 is formed in a band shape. The protective sheet 61 transmits monochromatic light having a desired wavelength output from the light source unit 10, a plurality of monochromatic lights having different wavelengths, or light having a wavelength close to these monochromatic lights.
The cleaning sheet 62 contacts the measuring unit 3 with a certain pressure and rubs to remove deposits on the measuring unit 3. That is, the cleaning sheet 62 is conveyed toward the collection case 6 together with the protective sheet 61. At this time, the cleaning sheet 62 comes into contact with the measuring unit 3 at a constant pressure, and friction is generated between the cleaning sheet 62 and the measuring unit 3. The cleaning sheet 62 is made of a fiber material. The cleaning sheet 62 includes a chemical component that cleans the measuring unit 3, such as ethanol.

  The plurality of coupling sheets 63 are sandwiched between the protective sheet 61 and the cleaning sheet 62, respectively, and are provided at predetermined intervals. Specifically, the protective sheet 61 and the cleaning sheet 62 are laminated, and for example, a plurality of circular holes are provided in the protective sheet 61 and the cleaning sheet 62 at regular intervals, and the coupling sheets 63 are respectively provided in the holes. Is provided. These coupling sheets 63 couple between the measurement unit 3 and the subject H. These coupling sheets 63 are formed in a circular shape, for example, as shown in the top view of FIG. These coupling sheets 63 are fixed to the protective sheet 61 and the cleaning sheet 62. These coupling sheets 61 are light transmissive and have high thermal conductivity, and include, for example, glassine paper coated with silicon. The coupling sheet 63 may be provided so as to be peelable from the protective sheet 61 and the cleaning sheet 62.

Specifically, the coupling sheet 63 includes a light transmitting portion 65 and an adhesive portion 66 each formed in a circular shape as shown in FIG. 19, for example. The light transmitting portion 65 and the bonding portion 66 are provided in a concentric manner with the light transmitting portion 65 as an inner side and the bonding portion 66 as an outer side.
The light transmission unit 65 transmits the light emitted from the measurement unit 3 and the light from the subject H. The light transmitting portion 65 is made of, for example, a silicon resin such as silicon rubber. The light transmission part 65 transmits light having a wavelength of 400 to 2500 nm, for example, and has a refractive index of 1.38 to 1.50. The light transmitting portion 65 has a thermal conductivity of 1.0 Mw / cm / ° C. or higher at a temperature of 10 to 45 ° C.

  The adhesion part 66 adheres to the subject H. The adhesive portion 66 is made of, for example, an acrylic adhesive emulsion. As shown in FIG. 20, the adhesive portion 66 includes a first layer adhesive portion 66a and a second layer adhesive portion 66b. The first layer adhesive portion 66a has a lower degree of adhesiveness than the adhesiveness of the second layer adhesive portion 66b. Therefore, the adhesive portion 66 has the highest adhesive strength between the protective sheet 61 and the cleaning sheet 62, then decreases in the order of the adhesive strength between the subject H and the adhesive strength between the peeling sheet 64 and the next. Has adhesive strength.

  When the coupling sheet 63 can be peeled off between the protective sheet 61 and the cleaning sheet 62, when the second layer adhesive portion 66b adheres to the subject H, the first layer adhesive portion 66a and the second layer adhesive portion. 66b has such a degree of adhesion that it is peeled off from being sandwiched between the protective sheet 61 and the cleaning sheet 62. The release sheet 64 can be peeled off from the second layer adhesive portion 66b and adheres to the subject H with a predetermined strength. As a result, the adhesive portion 66 has the highest adhesive strength with the subject H, then the adhesive strength between the protective sheet 61 and the cleaning sheet 62, and then the adhesive strength with the release sheet 64. Has reduced adhesive strength.

  The release sheet 64 is provided on the upper surface of the protective sheet 61 and each coupling sheet 63 and protects each coupling sheet 63. The release sheet 32 is peeled off from the protective sheet 61 and the coupling sheet 63 immediately before the coupling sheet 31 is attached to the subject H.

FIG. 21 shows an internal structure diagram of the biological information measuring apparatus using the integral coupling tape 60. The same parts as those in FIG. 1 are denoted by the same reference numerals, and detailed description thereof is omitted. In this biological information measuring device, the slide mechanism 44 is omitted from the device shown in FIG.
A coupling tape 60 is rotatably supported on the shaft 8 in the coupling tape case 5. The collection case 6 is supplied from the coupling tape case 5 to above the measuring unit 3 and collects the coupling tape 60 used for measurement.

Next, a measurement operation using the integrated coupling tape 60 will be described with reference to FIGS. 23A to 26A are top views, and FIGS. 23B to 26B are side views. Moreover, in the same figure, the several coupling sheet | seat 63 is shown as coupling sheet | seat 63-1, 63-2, 63-3 on the degree of description.
First, the coupling tape case 5 and the collection case 6 are each attached to the inside of the apparatus housing 1. The tip of the coupling tape 60 accommodated in the coupling tape case 5 is pulled out from the coupling tape case 5 and is locked to the shaft 9 of the collection case 6 through the upper part of the measuring unit 3. Further, the leading end portion of the release sheet 64 is peeled off from each of the protective sheets 61, is hung on the peeling roller 43, and is set in the collection passage.

  Next, a subject H such as a human arm is placed on the holder part 2 formed in a U-shape. In this state, the control unit 18 drives the drive unit 9 a to rotate the shaft 9 to wind the coupling tape 60 around the shaft 9, and the coupling tape 60 is wound along with the winding of the coupling tape 60. 60 is conveyed in the direction of arrow A. Along with the conveyance of the coupling tape 60, the release sheet 64 is guided into the collection passage through the release roller 43 and is released from the coupling sheet 60. The peeled release sheet 64 is collected.

  One coupling sheet 63-1 immediately after the release sheet 64 is peeled off as shown in FIG. 23A by the transport of the coupling tape 60 is below the measurement window 4 and is an abbreviation of the measurement window 4. When transported to the center, the control unit 18 stops driving the drive unit 9a and stops transporting the coupling tape 60. At this time, the coupling sheet 63-2 on the downstream side of the coupling sheet 63-1 from which the release sheet 64 has been peeled is present on the upstream side of the peeling roller 43 as shown in FIG. Is not peeled.

Next, the vertical mechanism 40 raises the measurement unit 3 by a predetermined distance in the direction of arrow B as shown in FIG. As the measurement unit 3 moves up, the measurement unit 3 pushes up the coupling tape 60 and presses it against a subject H such as a human arm. Thereby, the coupling sheet 63-1 is pressed against and attached to the subject H. As a result, the measurement unit 3 is coupled to the subject H through the coupling sheet 63-1. Thereby, the optical characteristic and thermal conductivity between the measurement part 3 and the subject H are improved. The rising distance of the measuring unit 3 includes, for example, the distance between the upper surface of the measuring unit 3 and the cleaning sheet 62 before the measuring unit 3 moves upward, the thickness of the cleaning sheet 62, the thickness of the protective sheet 61, and the protection. It is determined by adding the distance between the upper surface of the sheet 61 and the measurement window 4 and the rising distance for pressing the coupling sheet 63-1 to the subject H with a predetermined pressure.
In this state, the measurement unit 3 irradiates the subject H with light as described above, and non-invasively measures the substance in the subject H based on the light from the subject H at this time.

  When the noninvasive measurement of the substance in the subject H is completed, the vertical mechanism 40 lowers the measuring unit 3 in the direction of arrow B and returns it to the original position as shown in FIG. At this time, the coupling sheet 63-1 is peeled off from the subject H such as a human arm, and descends while being sandwiched between the protective sheet 61 and the cleaning sheet 62.

  At the next measurement time, the control unit 18 drives the drive unit 9 a for a predetermined period, rotates the shaft 9 and winds the coupling tape 60 around the shaft 9, and with the winding of the coupling tape 60. Then, the coupling tape 60 is conveyed in the direction of arrow A. The transport distance of the coupling tape 60 at this time is set to be the same as the arrangement interval of the coupling sheets 60. As a result, the release sheet 64 is guided into the collection passage through the release roller 43 and peeled off from the coupling sheet 60 as the coupling tape 60 is transported. The peeled release sheet 60 is collected.

  Along with the conveyance of the coupling tape 60, the cleaning sheet 63 comes into contact with the upper surface of the measuring unit 3 at a constant pressure as shown in FIG. A deposit on the upper surface, for example, a silicon resin such as silicon rubber that forms the light transmitting portion 65 of the coupling sheet 63 is wiped off. Since the cleaning sheet 63 contains a chemical component such as ethanol, the cleaning sheet 63 is wiped without leaving any deposits on the upper surface of the measuring unit 3.

As shown in FIGS. 26A and 26B, the next coupling sheet 63-2 from which the release sheet 62 has been peeled by the transport of the coupling tape 60 is below the measurement window 4 and the measurement window 4 When transported to a substantially central portion, the control unit 18 stops driving the drive unit 9a and stops transporting the coupling tape 60.
Thereafter, the substance in the subject H is measured in the same manner as described above.

Here, the cleaning of the measuring unit 3 by the cleaning sheet 63 will be described with reference to FIGS. 27 to 33.
When the coupling sheet 63-1 is conveyed to a position facing the measuring unit 3 as shown in FIG. 27 by the conveyance of the coupling tape 60, the measuring unit 3 rises as shown in FIG. It binds to the subject H via 63-1. In this state, the measurement unit 3 noninvasively measures a substance in the subject H.

  When the noninvasive measurement of the substance in the subject H is completed, the measuring unit 3 descends and returns to the original position as shown in FIG. At this time, a silicon resin 65 a such as silicon rubber that forms the transmission portion 65 of the coupling sheet 63-1 adheres to the upper surface of the measurement unit 3. That is, since the upper surface of the measurement unit 3 is pressure-bonded to the subject H such as a human arm via the coupling sheet 63-1, even if the measurement unit 3 is lowered, the silicon resin 65a or the like that forms the transmission unit 65 is the same. The part remains attached to the upper surface of the measuring part 3.

  At the time of the next measurement, as shown in FIG. 30, the coupling tape 60 is transported in the direction of arrow A along with the winding of the coupling tape 60. At this time, the measuring unit 3 rises as shown in FIG. The upper surface of the measuring unit 3 is brought into contact with the cleaning sheet 63 with a constant pressure. As a result, the upper surface of the measuring unit 3 comes into contact with the cleaning sheet 63 at a constant pressure and is rubbed by the movement of the cleaning sheet 63 as shown in FIG. For example, silicon resin such as silicon rubber that forms the light transmitting portion 65 of the coupling sheet 63 is wiped off.

  As described above, according to the second embodiment, the protective sheet 61, the cleaning sheet 62 provided on the lower surface of the protective sheet 61, and the plural sandwiched between the protective sheet 61 and the cleaning sheet 62. Since the integrated coupling tape 60 comprising the coupling sheet 63 and the release sheet 64 provided on the upper surface of the protective sheet 30 is used, the same effects as the effects of the first embodiment, that is, each cup Each of the ring sheets 63 has a uniform size, thickness, and the like, and the position where the ring sheet 63 is attached to the subject H can be made substantially the same, whereby the measurement unit 3 is connected to the subject H via the coupling tape 7. It is possible to improve the reproducibility of the state when the substance information in the subject H is measured by being coupled to the same, and the non-invasive measurement of the substance in the subject H under the same conditions can be performed.

At the time of non-invasive measurement of the substance in the subject H, the coupling sheet 63 is tightly sandwiched between the subject H and the measurement unit 3, so that reflection on the skin surface of the subject H such as a human arm is performed. Light can be suppressed, and light can be efficiently irradiated into the subject H such as a human arm.
The coupling sheet 63 is attached to the subject H by peeling the release sheet 32 immediately before starting noninvasive measurement of the substance in the subject H, and with the measuring unit 3 via the coupling sheet 63. Since the coupling with the subject H is performed, dust or the like adheres to the coupling sheet 31 and the measurement unit 3 and the subject H are not contaminated by the attached matter. Further, along with the conveyance of the coupling tape 7, the cleaning sheet 62 can be wiped without leaving any deposits on the upper surface of the measuring unit 3. Thereby, the transmitted light, reflected light, and scattered light according to the biological material information in the subject H can be received, and the accuracy of the measurement result can be maintained high. The work of wiping off the substance adhering to the upper surface of the measuring unit 3 is also eliminated.

Since the attachment of the coupling sheet 63 to the subject H is automatically performed by raising the measuring unit 3, for example, it is possible to eliminate the time and labor of the pasting operation by the manual operation of the operator. Since the coupling tape 7 is attached in the apparatus housing 1, the coupling tape 7 is not carried separately from the apparatus housing 1.
Since the coupling tape 7 after the coupling sheet 63 is used for measurement, that is, the protective sheet 61 and the cleaning sheet 62 are collected in the collection case 6, protection after using the entire coupling sheet 63. The sheet 61 and the cleaning sheet 62 can be discarded together. The release sheet 64 can be similarly collected and discarded.

  Since the plurality of coupling sheets 63 are provided integrally with the protective sheet 61 and the cleaning sheet 62, when the non-invasive measurement of the substance in the subject H is performed by raising the measurement unit 3, It is not necessary to retract the coupling tape 60 from the upper position of the measuring unit 3 as in the first embodiment. Thus, in the present embodiment, it is not necessary to provide the slide mechanism 44 that slides the coupling tape case 5 and the collection case 6 together in the apparatus housing 1 in the direction of arrow C.

  In the present embodiment, the integrated coupling tape 60 is applied to the apparatus shown in FIG. 21, but it can also be applied to the apparatus shown in FIG. In this case, in the apparatus shown in FIG. 1, it is not necessary to operate the slide mechanism 44, but it may be operated intentionally.

Note that the present invention is not limited to the above-described embodiment as it is, and can be embodied by modifying the constituent elements without departing from the scope of the invention in the implementation stage. In addition, various inventions can be formed by appropriately combining a plurality of components disclosed in the embodiment. For example, some components may be deleted from all the components shown in the embodiment. Furthermore, constituent elements over different embodiments may be appropriately combined.
For example, the coupling tape case 5 is provided with a tape supply port 70 as shown in FIG. The tape supply port 70 is provided with an open / close door 71. The opening / closing door 71 opens the tape supply port 70 when the coupling tapes 7 and 60 are fed. Further, as shown in FIG. 35, the open / close door 71 closes the tape supply port 70 when the tape feeding of the coupling tapes 7 and 60 is stopped. Thereby, the humidity in the coupling tape case 5 can be kept constant.

  For example, glassine paper having a strong paper strength may be used for each of the protective sheets 30 and 61 and each of the cleaning sheets 33 and 62. Thereby, each protection sheet 30 and 61 and each cleaning sheet 33 and 62 can prevent being cut | disconnected during conveyance.

Each adhesion part 35 and 66 in each coupling sheet 31 and 63 may change adhesive strength suitably, respectively. Thereby, it becomes possible to adjust the peeling force of each peeling sheet 32 and 64. FIG.
A mechanism for drying the surface of the subject H by wiping the surface of the subject H such as a human arm with a cotton member or the like, or by blowing wind on the surface of the subject H may be provided. Thereby, the coupling sheets 31 and 63 can be easily attached to the surface of the subject H.

  You may provide the mechanism which adjusts the conveyance position of each peeling type and integral type coupling tape 7 and 60 manually or automatically. Thereby, the conveyance position of each cleaning sheet 33 and 62 with respect to the measurement part 3 can be adjusted, and the deposit | attachment on the upper surface of the measurement part 3 can be wiped off reliably.

When the cleaning sheets 33 and 62 are slid while being brought into contact with the upper surface of the measuring unit 3, the cleaning sheets 33 and 62 are pressed against the upper surface of the measuring unit 3 with a constant pressure using, for example, a tape guide or the like. May be. The deposits on the upper surface of the measuring unit 3 can be reliably removed.
The transporting mechanism for the separation-type and integral-type coupling tapes 7 and 60 may be provided with a mechanism for transporting the coupling tapes 7 and 60 to the coupling tape case 5 and the collection case 6 at regular intervals, for example. Good.

  1: device housing, 2: holder unit, 3: measuring unit, 4: measuring window, 5: coupling tape case, 6: collection case, 7: coupling tape, 8, 9: shaft, 9a: driving unit, 10: light source unit, 11: multiplexing unit, 12: irradiation / light receiving unit, 13: interface unit, 14: light detection unit, 15: signal amplification unit, 16: temperature control unit, 17: temperature sensor, 18: control unit , 19: display unit, 20: operation unit, 21: data storage unit, 22: data collection unit, 23: signal processing unit, 24: power supply unit, 30: protective sheet, 31: peelable coupling sheet, 31- 1, 31-2, 31-3: coupling sheet, 32: release sheet, 33: cleaning sheet, 34: light transmission part, 35: adhesion part, 35a: first layer adhesion part, 35b: second layer adhesion part , 40: vertical mechanism, 41: armrest, 42: guide for peeling Member, 43: peeling roller, 44: slide mechanism, 50, 51: lower surface side tape guide, 52, 53: upper surface side tape guide, 54: recovery tape guide, 60: coupling tape, 61: protective sheet, 62 : Cleaning sheet, 63: Integrated coupling sheet, 63-1, 63-2, 63-3: Coupling sheet, 64: Release sheet, 65: Light transmission part, 65a: Silicon resin, 66: Adhesion part, 66a: 1st layer adhesion part, 66b: 2nd layer adhesion part.

Claims (22)

A measurement unit that non-invasively measures a substance in the subject based on light from the subject when the subject is irradiated with light;
A strip-shaped coupling tape that is interposed between the subject and the measurement unit, and couples between the subject and the measurement unit;
A transport mechanism for transporting the coupling tape;
Comprising
The coupling tape includes a sheet main body formed in a belt shape, and a coupling sheet provided in the sheet main body at predetermined intervals and transmitting light emitted from the measurement unit and light from the subject. A biological information measuring device comprising: A measurement unit that non-invasively measures a substance in the subject based on light from the subject when the subject is irradiated with light;
A sheet main body formed in a band shape, and a coupling sheet that is provided in the sheet main body at predetermined intervals and transmits light emitted from the measurement unit and light from the subject, and the subject A transport mechanism that transports a strip-shaped coupling tape that is interposed between the measurement unit and the subject and the measurement unit;
A biological information measuring device comprising:   The biological information measuring apparatus according to claim 1, wherein the coupling sheet is provided so as to be peelable from the sheet main body.   The biological information measuring apparatus according to claim 1, wherein the coupling sheet is provided integrally with the sheet main body.   The biological information measuring apparatus according to claim 1, wherein the coupling sheet is light transmissive and has high thermal conductivity.   The biological information measuring apparatus according to claim 1, wherein the coupling sheet includes glassine paper coated with silicon. The coupling sheet includes a light transmission unit that transmits the light emitted from the measurement unit and the light from the subject;
An adhesive part that adheres to the subject;
The living body information measuring device according to claim 1, wherein the living body information measuring device is provided.   The biological information measuring apparatus according to claim 7, wherein the light transmission part includes silicon rubber or silicon resin.   The light transmission part transmits light having a wavelength of 400 to 2500 nm, has a refractive index of 1.38 to 1.50, and has a thermal conductivity of 1.0 Mw / cm / ° C. or more at a temperature of 10 to 45 ° C. The biological information measuring device according to claim 7, comprising: Having a release sheet for protecting the coupling sheet;
The adhesive portion is peelable from the release sheet and adheres to the subject with a predetermined strength.
The living body information measuring device according to claim 7 characterized by things. Having a release sheet for protecting the coupling sheet;
The adhesive portion has an adhesive strength that decreases in the order of the adhesive strength between the subject, the adhesive strength between the sheet body, and the adhesive strength between the release sheet,
The living body information measuring device according to claim 7 characterized by things.   The biological information measuring apparatus according to claim 7, wherein the adhesive portion includes an acrylic pressure-sensitive adhesive emulsion.   The biological information measuring apparatus according to claim 1, wherein the coupling sheet is exchangeable for each subject.   The biological information measuring apparatus according to claim 1, further comprising a cleaning sheet that contacts the measuring unit at a constant pressure and rubs to remove the deposits on the measuring unit.   The biological information measuring apparatus according to claim 14, wherein the cleaning sheet is made of a fiber material.   The biological information measuring device according to claim 14, wherein the cleaning sheet includes a chemical component for cleaning the measuring unit. A release sheet provided on the sheet body and protecting the coupling sheet;
A peeling mechanism for peeling the release sheet;
The living body information measuring device according to claim 1, wherein the living body information measuring device is provided. The release sheet is detachably provided on the sheet body provided with the plurality of coupling sheets,
The transport mechanism transports the sheet main body for each distance between the coupling sheets,
The peeling mechanism peels the release sheet every time the sheet main body is transported by the transport mechanism.
The living body information measuring device according to claim 17 characterized by things.   The biological information measuring apparatus according to claim 18, wherein the peeling mechanism includes a plurality of guide rollers that peel and guide the peeling sheet from the sheet main body. The coupling sheet has a cleaning sheet for cleaning the measuring unit,
The transport mechanism transports the coupling sheet while removing the deposit on the measurement unit while bringing the cleaning sheet into contact with the measurement unit at a constant pressure.
The living body information measuring device according to claim 1 or 2 characterized by things. The transport mechanism includes a first case that houses the coupling tape in a wound state;
A second case for winding and collecting the coupling tape housed in the first case via the measuring unit;
The biological information measuring device according to claim 1, wherein   The biological information measuring apparatus according to claim 21, wherein the first and second cases are formed airtight.

Images