JP2012115545A5 - - Google Patents
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- JP2012115545A5 JP2012115545A5 JP2010269108A JP2010269108A JP2012115545A5 JP 2012115545 A5 JP2012115545 A5 JP 2012115545A5 JP 2010269108 A JP2010269108 A JP 2010269108A JP 2010269108 A JP2010269108 A JP 2010269108A JP 2012115545 A5 JP2012115545 A5 JP 2012115545A5
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- semiconductor switch
- current source
- stimulation
- circuit
- living tissue
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- 239000004065 semiconductor Substances 0.000 claims description 40
- 230000000638 stimulation Effects 0.000 claims description 23
- 238000001514 detection method Methods 0.000 claims description 4
- 230000004936 stimulating effect Effects 0.000 claims 2
Description
(1) 電源側の第1半導体スイッチと接地側の第3半導体スイッチを直列接続してなる第1直列部と,電源側の第2半導体スイッチと接地側の第4半導体スイッチを直列接続してなる第2直列部とが並列接続されてなるHブリッジ回路と、前記第1直列部の第1半導体スイッチと第3半導体スイッチとの間の第1接続点に接続される刺激電極と、前記第2直列部の第2半導体スイッチと第4半導体スイッチとの間の第2接続点に接続される対向電極と、前記第3半導体スイッチ及び前記第4半導体スイッチの接地側の一端に設けられる第1電流源であって,前記刺激電極から出力される電流値を定めるための第1電流源と、前記第1半導体スイッチ及び前記第2半導体スイッチの電源側の一端に設けられる第2電流源であって,前記刺激電極から出力される電流値を定める第2電流源と、を備えることを特徴とする。
(2) (1)の生体組織用刺激回路において、前記Hブリッジ回路の対向する前記第1半導体スイッチ及び前記第4半導体スイッチの組み合わせと、前記第2半導体スイッチと前記第3半導体スイッチとの組み合わせのオンとオフが交互に切換えられることにより、前記刺激電極から出力される双極性の電気刺激パルス信号の1stパルスと2ndパルスの正負の電流の極性が切換えられることを特徴とする。
(3) (1)又は(2)の生体組織用刺激回路において、前記電源側及び前記接地側のうち少なくとも一方には、前記第1電流源又は前記第2電流源と前記Hブリッジ回路との電気的な接続の有無を切換えるために,前記第1電流源又は前記第2電流源に対して並列接続されるバイパススイッチが設けられていることを特徴とする。
(4) (3)の生体組織用刺激回路において、前記バイパススイッチは少なくとも前記第1半導体スイッチ及び第3半導体スイッチに対してそれぞれ並列接続される又は、前記接地側に接続される前記第2半導体スイッチと第4半導体スイッチに対してそれぞれ並列接続されることを特徴とする。
(5) (3)又は(4)の生体組織用刺激回路において、前記第1電流源又は前記第2電流源に並列接続される前記バイパススイッチのうち少なくとも一方は、前記1stパルスの出力時にオンとされ,前記2ndパルスの出力時にオフとされることを特徴とする。
(6) (3)から(5)何れかの生体組織用刺激回路において、前記第1接続点及び前記第2接続点の電位差を検出するための電位差検出回路を備え、該電位差検出回路で検出された電位差に基づき前記第1電流源又は前記第2電流源に並列接続される前記バイパススイッチのうち少なくとも一方をオンとすることを特徴とする。
(1) A first series part formed by connecting a first semiconductor switch on the power supply side and a third semiconductor switch on the ground side in series, and a second semiconductor switch on the power supply side and a fourth semiconductor switch on the ground side connected in series. An H bridge circuit in which the second series part is connected in parallel; a stimulation electrode connected to a first connection point between the first semiconductor switch and the third semiconductor switch of the first series part; A counter electrode connected to a second connection point between the second semiconductor switch and the fourth semiconductor switch in the two series portions, and a first electrode provided at one end on the ground side of the third semiconductor switch and the fourth semiconductor switch; A first current source for determining a current value output from the stimulation electrode; and a second current source provided at one end of the first semiconductor switch and the second semiconductor switch on the power source side. The stimulation electrode And a second current source that determines a current value output from.
(2) In the biological tissue stimulation circuit according to (1), a combination of the first semiconductor switch and the fourth semiconductor switch facing each other of the H bridge circuit, and a combination of the second semiconductor switch and the third semiconductor switch By alternately switching on and off, the polarity of the positive and negative currents of the 1st pulse and 2nd pulse of the bipolar electrical stimulation pulse signal output from the stimulation electrode is switched.
(3) In the biological tissue stimulation circuit according to (1) or (2), at least one of the power supply side and the ground side includes the first current source or the second current source and the H bridge circuit. In order to switch the presence or absence of electrical connection, a bypass switch connected in parallel to the first current source or the second current source is provided.
(4) in a biological tissue for stimulation circuit (3), the bypass switch or is connected in parallel respectively to at least said first semiconductor switch and the third semiconductor switch, the second semiconductor connected to the ground side The switch and the fourth semiconductor switch are respectively connected in parallel.
(5) In the biological tissue stimulation circuit according to (3) or (4) , at least one of the bypass switches connected in parallel to the first current source or the second current source is turned on when the first pulse is output. And is turned off when the 2nd pulse is output.
(6) In the (3) (5) one of the biological tissue for stimulation circuit includes a potential difference detection circuit for detecting a potential difference of the first connecting point and the second connecting point, detected by the potential difference detection circuit Based on the potential difference, at least one of the bypass switches connected in parallel to the first current source or the second current source is turned on.
Claims (6)
前記第1直列部の第1半導体スイッチと第3半導体スイッチとの間の第1接続点に接続される刺激電極と、
前記第2直列部の第2半導体スイッチと第4半導体スイッチとの間の第2接続点に接続される対向電極と、
前記第3半導体スイッチ及び前記第4半導体スイッチの接地側の一端に設けられる第1電流源であって,前記刺激電極から出力される電流値を定めるための第1電流源と、
前記第1半導体スイッチ及び前記第2半導体スイッチの電源側の一端に設けられる第2電流源であって,前記刺激電極から出力される電流値を定める第2電流源と、
を備えることを特徴とする生体組織用刺激回路。 A first series part in which the first semiconductor switch on the power source side and the third semiconductor switch on the ground side are connected in series, and a second serial part in which the second semiconductor switch on the power source side and the fourth semiconductor switch on the ground side are connected in series. An H bridge circuit in which a series part is connected in parallel;
A stimulation electrode connected to a first connection point between the first semiconductor switch and the third semiconductor switch of the first series part;
A counter electrode connected to a second connection point between the second semiconductor switch and the fourth semiconductor switch of the second series portion;
A first current source provided at one end on the ground side of the third semiconductor switch and the fourth semiconductor switch, the first current source for determining a current value output from the stimulation electrode;
A second current source provided at one end on the power source side of the first semiconductor switch and the second semiconductor switch, wherein the second current source determines a current value output from the stimulation electrode;
A stimulating circuit for living tissue, comprising:
前記Hブリッジ回路の対向する前記第1半導体スイッチ及び前記第4半導体スイッチの組み合わせと、前記第2半導体スイッチと前記第3半導体スイッチとの組み合わせのオンとオフが交互に切換えられることにより、前記刺激電極から出力される双極性の電気刺激パルス信号の1stパルスと2ndパルスの正負の電流の極性が切換えられることを特徴とする生体組織用刺激回路。The combination of the first semiconductor switch and the fourth semiconductor switch facing each other in the H-bridge circuit and the combination of the second semiconductor switch and the third semiconductor switch are alternately switched on and off, whereby the stimulation A stimulation circuit for living tissue, wherein the polarity of positive and negative currents of the 1st pulse and 2nd pulse of a bipolar electrical stimulation pulse signal output from an electrode is switched.
前記電源側及び前記接地側のうち少なくとも一方には、前記第1電流源又は前記第2電流源と前記Hブリッジ回路との電気的な接続の有無を切換えるために,前記第1電流源又は前記第2電流源に対して並列接続されるバイパススイッチが設けられていることを特徴とする生体組織用刺激回路。 The stimulation circuit for living tissue according to claim 1 or 2 ,
At least one of the power supply side and the ground side is configured to switch the first current source or the second current source and the H bridge circuit with or without electrical connection. A stimulating circuit for living tissue, wherein a bypass switch connected in parallel to the second current source is provided.
前記バイパススイッチは少なくとも前記第1半導体スイッチ及び第3半導体スイッチに対してそれぞれ並列接続される又は、前記接地側に接続される前記第2半導体スイッチと第4半導体スイッチに対してそれぞれ並列接続されることを特徴とする生体組織用刺激回路。 The stimulation circuit for living tissue according to claim 3 ,
The bypass switch is connected in parallel to at least the first semiconductor switch and the third semiconductor switch, or connected in parallel to the second semiconductor switch and the fourth semiconductor switch connected to the ground side. A stimulation circuit for living tissue characterized by the above.
前記第1電流源又は前記第2電流源に並列接続される前記バイパススイッチのうち少なくとも一方は、前記1stパルスの出力時にオンとされ,前記2ndパルスの出力時にオフとされることを特徴とする生体組織用刺激回路。 The stimulation circuit for living tissue according to claim 3 or 4 ,
At least one of the bypass switches connected in parallel to the first current source or the second current source is turned on when the first pulse is output and turned off when the second pulse is output. Stimulation circuit for living tissue.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010269108A JP2012115545A (en) | 2010-12-02 | 2010-12-02 | Living tissue stimulation circuit |
US13/289,440 US8504167B2 (en) | 2010-11-05 | 2011-11-04 | Living tissue stimulation circuit |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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JP2010269108A JP2012115545A (en) | 2010-12-02 | 2010-12-02 | Living tissue stimulation circuit |
Publications (2)
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JP2012115545A JP2012115545A (en) | 2012-06-21 |
JP2012115545A5 true JP2012115545A5 (en) | 2014-01-23 |
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JP2010269108A Ceased JP2012115545A (en) | 2010-11-05 | 2010-12-02 | Living tissue stimulation circuit |
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Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103313754B (en) | 2010-11-16 | 2015-09-30 | 小利兰·斯坦福大学理事会 | Be used for the treatment of the system and method for xerophthalmia |
US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
JP6048053B2 (en) * | 2012-10-11 | 2016-12-21 | 株式会社ニデック | Biological tissue stimulator |
US9717627B2 (en) | 2013-03-12 | 2017-08-01 | Oculeve, Inc. | Implant delivery devices, systems, and methods |
NZ704579A (en) * | 2013-04-19 | 2018-10-26 | Oculeve Inc | Nasal stimulation devices and methods |
CN106470673B (en) | 2014-02-25 | 2020-01-31 | 奥库利维公司 | Polymer formulations for nasolacrimal stimulation |
JP6643313B2 (en) | 2014-07-25 | 2020-02-12 | オキュリーブ, インコーポレイテッド | Stimulation patterns for treating dry eye |
ES2809599T3 (en) | 2014-10-22 | 2021-03-04 | Oculeve Inc | Stimulation devices to treat dry eyes |
WO2016065211A1 (en) | 2014-10-22 | 2016-04-28 | Oculeve, Inc. | Contact lens for increasing tear production |
US10426958B2 (en) | 2015-12-04 | 2019-10-01 | Oculeve, Inc. | Intranasal stimulation for enhanced release of ocular mucins and other tear proteins |
US10252048B2 (en) | 2016-02-19 | 2019-04-09 | Oculeve, Inc. | Nasal stimulation for rhinitis, nasal congestion, and ocular allergies |
CA3022683A1 (en) | 2016-05-02 | 2017-11-09 | Oculeve, Inc. | Intranasal stimulation for treatment of meibomian gland disease and blepharitis |
KR101838150B1 (en) * | 2016-08-31 | 2018-03-15 | 가천대학교 산학협력단 | Photodiode array based sub-retinal prosthetic device and method thereby |
JP2020500609A (en) | 2016-12-02 | 2020-01-16 | オキュリーブ, インコーポレイテッド | Apparatus and method for dry eye prediction and treatment recommendations |
CN109939352B (en) * | 2017-12-20 | 2023-04-11 | 上海力声特医学科技有限公司 | Electronic cochlea, electronic cochlea implant body and stimulating electrode polar array circuit applied to same |
JP7302268B2 (en) * | 2019-05-09 | 2023-07-04 | 株式会社ニデック | vision regeneration aid |
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US6208895B1 (en) * | 1998-10-13 | 2001-03-27 | Physio-Control Manufacturing Corporation | Circuit for performing external pacing and biphasic defibrillation |
US7222290B2 (en) * | 2003-11-18 | 2007-05-22 | Agere Systems Inc. | Method and apparatus for receiver detection on a PCI-Express bus |
JP4099590B2 (en) * | 2004-03-17 | 2008-06-11 | ソニー株式会社 | WRITE DRIVER CIRCUIT FOR MAGNETIC HEAD AND MAGNETIC RECORDING DEVICE HAVING THE CIRCUIT |
JP4359567B2 (en) * | 2005-01-05 | 2009-11-04 | 株式会社ニデック | Visual reproduction assist device and method of manufacturing the same |
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