JP2012087107A - Silica-containing gel composition, anti-inflammatory agent, water-retaining agent and cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To achieve serviceability as anti-inflammatory property, moisture-retaining property or a cosmetic which cannot be entirely anticipated from knowledge until now, by enabling enlargement of utilization of silica as medical treatment, a cosmetic or the like, and by enabling formation of a new constitution of a stable silica-colloid viscous fluid which cannot be entirely expected so far.SOLUTION: This invention relates to a silica-containing gel composition in which a mixture of (A) spherical silica and (B) a dispersion medium which is at least one kind of oil-and-fat and silicone oil is blended with (C) at least one kind of water and organic hydroxy compound.

Description

  The present invention relates to a viscous jelly-like silica-containing gel composition, and an anti-inflammatory agent, a water retention agent and a cosmetic comprising the same as an active ingredient.

Silica (SiO ₂ ) is a silicon oxide that occupies about 60% of the earth, and is used as a filler material for sealing materials, an anti-blocking material, a filler material for precision resin molding, a filler for wax, a raw material for sintered ceramics, etc. It is used for various industrial applications. Silica is useful in daily life and medical applications such as cleaning agents and dental materials, and in daily life as a cosmetic ingredient.

  However, even though silica is an important element for human skin, hair, and nail health, its use for medical treatment, cosmetics, and the like has not progressed much. In the background, it has been conventionally considered that silica is difficult to constitute a viscous jelly-like composition. The reason is that no means has been found for making silica particles a stable colloidal viscous fluid. For this reason, conventionally, silica is only added to creams, lotions and the like as auxiliary components when used for medical purposes, cosmetics and the like.

  Silica is only applied as a powder for drying or baby powder.

  From the background as described above, it is an object of the present invention to provide a new technical measure that enables the expansion of the use of silica as a medical treatment or cosmetics, and enables the construction of a stable silica-colloid viscous fluid. Yes.

  The present invention is characterized by the following as means for solving the above problems.

  That is, (C) silica in which (C) at least one of water and an organic hydroxy compound is blended in a mixture of spherical silica and (B) a dispersion medium that is at least one of oil and silicon oil It is a containing gel composition.

  Here, the mass ratio of (A) spherical silica and (B) the dispersion medium which is at least one kind of oil and fat is in the range of 1:10 to 10: 1, and 0.5 to It is preferable that at least one of (C) water and an organic hydroxy compound in a proportion within the range of 5% by mass is blended.

  The following is also preferable.

  (A) The volume average particle diameter of the spherical silica is less than 1 μm, and the sphericity is 0.5 or more.

  The oil for the dispersion medium is plant seed oil.

  The organic hydroxy compound is at least one of a low molecular alcohol having 1 to 3 carbon atoms or a hydroxycarboxylic acid.

  And this invention also provides the anti-inflammatory agent, skin moisturizer, and cosmetics characterized by using either of the above silica-containing gel compositions as an active ingredient.

  According to the present invention, it is possible to expand the use of silica as medical care, cosmetics, etc., and to enable a new structure of a stable silica colloid viscous fluid that has never been expected before.

  In addition, according to the present invention, anti-inflammatory properties, moisture retention, and usefulness as a cosmetic material, which cannot be predicted from the knowledge so far, are realized.

The optical micrograph (x1200) of the gel composition of this invention is illustrated.

  The jelly-like silica-containing gel composition as a stable silica-colloid viscous fluid of the present invention has a mixture of (A) spherical silica and at least one of (B) oil and silicon oil as a dispersion medium, (C) It is essential that at least one of water and an organic hydroxy compound is added and blended. Here, the said component (C) can also be called a stabilizer.

  It is essential that the component (C) is added and blended with the mixture of the components (A) and (B), and the component (A) can be prepared even in the simultaneous stirring mixture of the components (A), (B), and (C). It is important that the component (B) is not added to the stirred mixture of (C).

  It is presumed that for the first time in the present invention, the absolute value of the zeta potential can be increased and the colloidal particles can be stabilized by adsorbing the component (C) on the surface of the silica colloidal particles as a stabilizer.

  (A) About spherical silica, various spherical shapes, such as a true spherical shape and an elliptical spherical shape, can be used. More preferably, silica having a sphericity of 0.5 or more is considered.

  The volume average particle size is preferably 5 μm or less, and more preferably less than 1 μm. More preferably, it is the range of 0.02 micrometer-0.8 micrometer.

  Synthetic silica is considered for such spherical silica. Alternatively, it may be natural silica.

  (B) The fats and oils as a dispersion medium show the triglyceride which is a compound of a fatty acid and glycerin. About these, the thing liquid at normal temperature (about 10 to 28 degreeC) as a vegetable oil or fish oil is considered suitably. For example, plant seed oils such as soybean oil, sunflower oil, rice germ oil, safflower oil, corn oil, olive oil, peanut oil, canola oil, and sesame oil are preferred examples.

  In the present invention, silicon oil, that is, one having a (-Si-O-) n skeleton is also effective.

  Two or more of the above may be used.

  Conventionally, hydrocarbons such as kerosene and squalane, which have been studied as silica gels, are not effective in the present invention and cannot be used.

  Moreover, it is preferable that it is deionized water about the water of the component (C) which can also be called a stabilizer. For organic hydroxy compounds, alcohols, phenols, hydroxycarboxylic acids and the like are considered. Of these, low molecular alcohols having 1 to 3 carbon atoms such as methanol, ethanol, 1-propanol, isopropanol, ethylene glycol, and propylene glycol are preferable. Further, low molecular hydroxycarboxylic acids such as lactic acid are also preferred.

  Two or more kinds of water and the organic hydroxy compound may be used. In the silica-containing gel composition of the present invention, the mass ratio of the component (A) spherical silica and the (B) dispersion medium is preferably in the range of 1:10 to 10: 1. In particular, the range of 1: 3 to 3: 1 is more preferable. The mixture of component (A) spherical silica and (B) dispersion medium is a dispersion mixture obtained by stirring. On the other hand, component (C) has a total mass of 0. 0 of the total mass of components (A) and (B). It is preferable to add and mix in a proportion corresponding to 5 to 5% by mass. If it is less than 0.5%, gelation tends to be difficult, and if it exceeds 5%, gelation tends to be difficult due to phase separation.

  The silica-containing gel composition of the present invention can be suitably used as a jelly-like gel for medical use, cosmetic use and the like. For example, when used on the body of dry skin, it takes in atmospheric moisture and improves the moisture retention of the skin. In addition, the transpiration of moisture from the skin surface is suppressed.

  It is also useful as an external anti-inflammatory agent that suppresses inflammation of the skin and nails. For example, it has an excellent effect of treating and preventing discoloration and deformation of the limbs and nails called “meat-up” that occurs in meat processing workers, and itching and pain due to skin irritation. Antibacterial action is also considered.

  As a cosmetic, it is also useful as a material that exhibits moisturizing properties and anti-inflammatory properties.

  In particular, in the gel composition of the present invention, it is possible to provide more reliable safety by using a composition with components derived from natural products such as plant seed oil, water and ethanol, and components used in medicine and cosmetics. It is possible to provide a highly reliable product. This is also a major feature of the present invention.

  Of course, in the silica gel composition of the present invention, various components commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., within a range that does not impair the gel composition and its effect, corresponding to its purpose and use. For example, higher fatty acids, higher alcohols, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, preservatives, saccharides, sequestering agents, polymers such as water-soluble polymers, thickeners , Powder components, ultraviolet absorbers, ultraviolet shielding agents, humectants, fragrances, pH adjusters, and the like can be supplementarily blended. In addition, vitamins, skin activators, blood circulation promoters, active oxygen scavengers, anti-inflammatory agents, whitening agents, other medicinal components such as bactericides, bioactive components, and the like can be blended.

  Specific examples of the higher fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA).

  Specific examples of higher alcohols include linear alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol, cetostearyl alcohol, branched alcohols such as monostearyl glycerol ether, lanolin alcohol, cholesterol, phytosterol, octyldodecanol, and the like. It is done.

  Specific examples of the anionic surfactant include fatty acid salts such as sodium laurate, higher alkyl sulfate salts such as sodium lauryl sulfate, alkyl ether sulfate salts such as POE lauryl sulfate triethanolamine, N-acyl sarcosine acid, sulfosuccinate. Acid salts, N-acylamino acid salts and the like.

  Specific examples of the cationic surfactant include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride, benzalkonium chloride, and benzethonium chloride.

  Specific examples of the amphoteric surfactant include betaine surfactants such as alkyl betaines and amide betaines.

  Specific examples of the nonionic surfactant include sorbitan fatty acid esters such as sorbitan monooleate, and hardened castor oil derivatives.

  Specific examples of the preservative include methyl paraben and ethyl paraben.

  Specific examples of the sequestering agent include edetate salts such as disodium ethyldiaminetetraacetate, edetic acid, and sodium edetate.

  Specific examples of the polymer include gum arabic, gum tragacanth, galactan, guar gum, carrageenan, pectin, agar, quince seed, dextran, pullulan, carboxymethyl starch, collagen, casein, gelatin, methylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, Examples thereof include vinyl polymers such as sodium carboxymethylcellulose (CMC), sodium alginate, and carboxyvinyl polymer.

  Specific examples of the thickener include carrageenan, tragacanth gum, quince seed, casein, dextrin, gelatin, CMC, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxyvinyl polymer, guar gum, xanthan gum, bentonite and the like.

  Specific examples of the powder component include talc, kaolin, mica, zeolite, polyethylene powder, polystyrene powder, cellulose powder, inorganic white pigment, inorganic red pigment, titanium oxide coated mica, titanium oxide coated talc, and colored titanium oxide coated mica. Pearl pigments such as red, and organic pigments such as red 201 and red 202.

  Specific examples of the ultraviolet absorber include paraaminobenzoic acid, phenyl salicylate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2,4-dihydroxybenzophenone, and the like.

  Specific examples of the ultraviolet shielding agent include titanium oxide, talc, carmine, bentonite, kaolin, and zinc oxide.

  Specific examples of the humectant include polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, glycerin, diglycerin, polyglycerin, xylitol, maltitol, maltose, sorbitol, glucose Fructose, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, pyrrolidone carboxylic acid, cyclodextrin and the like.

  The composition of the present invention can be applied, for example, in the form of a solution such as an aqueous solution, oil, emulsion, suspension, semi-solid agent such as gel or cream, or solid agent such as solid. It can be prepared in these forms by conventionally known methods, and can be made into various dosage forms such as lotions, emulsions, gels, creams, ointments, plasters, haps, etc. Can be applied. Among these dosage forms, lotions, emulsions, creams, ointments, plasters, haptics and the like are particularly suitable for the external composition for skin.

  The composition of the present invention is more effective as a practical technique as a topical preparation for cosmetics and the like by being dispersed in water or an aqueous solvent such as a mixture of alcohol and water. Be expanded.

  Therefore, an example will be shown and described in more detail below. Of course, the present invention is not limited to the following examples.

<Silica gel composition>
As spherical silica, Admatech Co., Ltd. (sphericity> 0.7, specific surface area <30 m ² / g, volume average particle size 0.5 μm) was used.

  (1) 20 g of this spherical silica and 20 g of the dispersion medium were stirred and mixed, then 0.8 g of RO water (corresponding to a mass ratio of 2%) was added and stirred, and the presence or absence of gelation was evaluated. As a result, it was confirmed that in any case of soybean oil, camellia oil, rice germ oil, sunflower oil, silicon oil, or fish oil as a dispersion medium, a viscous jelly-like gelled product was uniformly mixed. FIG. 1 is an optical micrograph (× 1200) of the gel composition in the case of soybean.

  On the other hand, when kerosene or squalane was used as a dispersion medium as an example of hydrocarbons, separation from silica occurred and a uniformly mixed gel could not be obtained.

  (2) 20 g of the silica and 20 g of soybean oil were mixed with stirring, then 0.8 g of various stabilizers such as water were added and stirred, and the presence or absence of gelation was evaluated. As a result, gelation was performed for RO water (conductivity 2 ppm), tap water (conductivity 37 ppm), methanol, ethanol, 1-propanol, isopropanol, ethylene glycol, propylene glycol, lactic acid, 75% ethanol aqueous solution, and 20% acetic acid aqueous solution. confirmed. On the other hand, for each of acetone, acetic acid, DMF, and acetonitrile, a stable and viscous gel that was uniformly mixed could not be obtained.

  (3) For comparison, 20 g of silica, 20 g of soybean oil, and 0.8 g of RO water were stirred and mixed at the same time, but a uniformly mixed gel was not obtained, and a gel state in which silica was partially aggregated was obtained. Further, 20 g of silica and 0.8 g and 10 g of RO water were stirred and mixed, and then 20 g of soybean oil was added and stirred. However, in any case, a mixed gel was not obtained, and silica was partially agglomerated. It became a gel state.

When 20 g of silica and 20 g of soybean oil were stirred and mixed without using water as a stabilizer, a sticky state was obtained, and a uniform and good-quality viscous gel could not be obtained. This is considered to be due to the fact that the oil component cannot be uniformly held between the silica particles and a stable colloidal gel is not formed.
<Preparation of body cream>
A body cream was prepared using the spherical silica as follows.

Spherical silica and fats and oils (mass ratio 1: 1: 1) composed of soybean oil, rice germ oil, and daikyo oil were stirred and mixed at a mass ratio of 1: 1. To the resulting mixture, RO water corresponding to a mass ratio of 3% is added together with carrot extract (equivalent to 0.5%) and acetylglucosamine (equivalent to 0.2%), and the silica gel composition is effectively stirred. A body cream as an ingredient was prepared.
<Skin irritation: application to meat-cutting>
When the body cream was applied to 8 men and 5 women who were engaged in meat processing work and suffered discoloration or deformation of any of the limbs, skin discoloration, pain or itching, both were discolored. It was confirmed that deformation, pain and itching were improved, and that continuous use of the body cream was effective and necessary.
<Skin inflammation: Application to rash and itching>
When the body cream was applied 2-3 times a day to subjects who have been treated with steroids for rash (eczema) and itching that have been diagnosed as being caused by stress for many years, the affected area of the rash becomes flat and itchy It was confirmed that it disappeared in a few days. Rashes and itching that have been plagued for many years can now be addressed by the use of this body cream without the use of steroids, which are of concern for long-term application.

Claims (8)

  (C) At least one of (C) water and an organic hydroxy compound is blended in a mixture of (A) spherical silica and (B) a dispersion medium that is at least one of oil and silicon oil. A silica-containing gel composition.   The mass ratio of (A) spherical silica and (B) the dispersion medium which is at least one kind of oil and fat is within the range of 1:10 to 10: 1, and is 0.5 to 5% by mass with respect to the total amount. 2. The silica-containing gel composition according to claim 1, wherein at least one of (C) water and an organic hydroxy compound in a proportion within the range of 1 is blended.   (A) The silica gel composition according to claim 1 or 2, wherein the spherical silica has a volume average particle diameter of less than 1 μm and a sphericity of 0.5 or more.   The silica-containing gel composition according to any one of claims 1 to 3, wherein the fat or oil of the dispersion medium is plant seed oil.   The silica-containing gel composition according to any one of claims 1 to 4, wherein the organic hydroxy compound is at least one kind of a low molecular alcohol having 1 to 3 carbon atoms or a hydroxycarboxylic acid. object.   An anti-inflammatory agent comprising the silica-containing gel composition according to any one of claims 1 to 5 as an active ingredient.   A skin moisturizer comprising the silica-containing gel composition according to any one of claims 1 to 5 as an active ingredient.   A cosmetic comprising the silica-containing gel composition according to any one of claims 1 to 5 as an active ingredient.