JP2012001477A - Method for producing thiourea compound - Google Patents
Method for producing thiourea compound Download PDFInfo
- Publication number
- JP2012001477A JP2012001477A JP2010137202A JP2010137202A JP2012001477A JP 2012001477 A JP2012001477 A JP 2012001477A JP 2010137202 A JP2010137202 A JP 2010137202A JP 2010137202 A JP2010137202 A JP 2010137202A JP 2012001477 A JP2012001477 A JP 2012001477A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- thiourea
- group
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Description
本発明は環状カルボジイミド化合物の中間体として有用なチオウレア体の製造方法に関し、さらに詳しくは特定のチオウレア体の製造方法に関する。 The present invention relates to a method for producing a thiourea compound useful as an intermediate of a cyclic carbodiimide compound, and more particularly to a method for producing a specific thiourea compound.
ポリエステル等のエステル結合を有する化合物は、カルボキシル基等の極性基により加水分解が促進されるため、カルボキシル基の封止剤を適用して、カルボキシル基濃度を低減することが提案されている（特許文献１、特許文献２）。かかるカルボキシル基の封止剤として、カルボジイミド化合物が使用されている。
しかし、このカルボジイミド化合物は、いずれも線状の化合物であるため、使用時、揮発性のイソシアネート化合物が副生して、悪臭を発し、作業環境を悪化させるという欠点を有する。
そこで、本発明者は、封止剤として、カルボキシル基と反応してもイソシアネート化合物が副生しない環状カルボジイミド化合物を見出し国際出願した（特許文献３）。しかし、この有用な環状カルボジイミド化合物およびその中間体の工業的な製造方法は確立されていない。
Since a compound having an ester bond such as polyester is accelerated by a polar group such as a carboxyl group, it has been proposed to reduce the carboxyl group concentration by applying a carboxyl group sealant (patent) Literature 1, Patent Literature 2). A carbodiimide compound is used as such a carboxyl group sealing agent.
However, since all of these carbodiimide compounds are linear compounds, a volatile isocyanate compound is produced as a by-product during use, and has a drawback of producing a bad odor and deteriorating the working environment.
Then, this inventor discovered the cyclic carbodiimide compound by which an isocyanate compound does not byproduce even if it reacts with a carboxyl group as a sealing agent, and applied internationally (patent document 3). However, an industrial production method for this useful cyclic carbodiimide compound and its intermediate has not been established.
そこで本発明の目的は、環状カルボジイミド化合物の中間体の製造方法を提供することにある。 Therefore, an object of the present invention is to provide a method for producing an intermediate of a cyclic carbodiimide compound.
本発明者は、環状カルボジイミド化合物の中間体の工業的製造方法について検討した結果、式（Ａ）で表されるアミン体に二硫化炭素を反応させ式（Ｂ）で表されるチオウレア体を合成する際に、イミダゾールを存在させると、収率が顕著に向上することを見出し、本発明を完成した。 As a result of studying an industrial production method of an intermediate of a cyclic carbodiimide compound, the present inventors synthesized a thiourea compound represented by formula (B) by reacting carbon disulfide with an amine compound represented by formula (A). In this case, it was found that the yield was remarkably improved when imidazole was present, and the present invention was completed.
即ち本発明は、以下の発明を包含する。
１． 下記式（Ａ）で表されるアミン体と二硫化炭素とをイミダゾールの存在下で反応させる工程を含む、下記式（Ｂ）で表されるチオウレア体の製造方法である。
That is, the present invention includes the following inventions.
1. It is a manufacturing method of the thiourea body represented by a following formula (B) including the process with which the amine body represented by a following formula (A) and carbon disulfide are made to react in presence of imidazole.
（式（Ａ）中、Ｒは、水素原子または炭素原子数１〜６のアルキル基である。） (In the formula (A), R is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms.)
（式（Ｂ）中、Ｒは式（Ａ）と同じである。）
２． 反応溶媒としてメチルエチルケトンを使用する前項１記載の製造方法。
(In formula (B), R is the same as in formula (A).)
2. 2. The production method according to 1 above, wherein methyl ethyl ketone is used as the reaction solvent.
本発明の製造方法によれば、環状カルボジイミド化合物の中間体として有用な、式（Ｂ）で表されるチオウレア体を高収率で製造することができる。 According to the production method of the present invention, a thiourea compound represented by the formula (B), which is useful as an intermediate of a cyclic carbodiimide compound, can be produced in a high yield.
本発明は、下記式（Ａ）で表されるアミン体と二硫化炭素（ＣＳ２）とを、イミダゾールの存在下で反応させる工程を含む。
（アミン体）
アミン体は下記式（Ａ）で表される。
The present invention includes a step of reacting an amine compound represented by the following formula (A) with carbon disulfide (CS 2 ) in the presence of imidazole.
(Amine body)
The amine body is represented by the following formula (A).
式（Ａ）中、Ｒは、水素原子または炭素原子数１〜６のアルキル基である。炭素原子数１〜６のアルキル基として、メチル基、エチル基、ｎ−プロピル基、ｓｅｃ−プロピル基、ｉｓｏ−プロピル基、ｎ−ブチル基、ｔｅｒｔ−ブチル基、ｓｅｃ−ブチル基、ｉｓｏ−ブチル基、ｎ−ペンチル基、ｓｅｃ−ペンチル基、ｉｓｏ−ペンチル基、ｎ−ヘキシル基、ｓｅｃ−ヘキシル基、ｉｓｏ−ヘキシル基等が挙げられる。 In formula (A), R is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms. Examples of the alkyl group having 1 to 6 carbon atoms include methyl group, ethyl group, n-propyl group, sec-propyl group, iso-propyl group, n-butyl group, tert-butyl group, sec-butyl group and iso-butyl. Group, n-pentyl group, sec-pentyl group, iso-pentyl group, n-hexyl group, sec-hexyl group, iso-hexyl group and the like.
（チオウレア体）
本発明の製造方法で得られるチオウレア体は下記式（Ｂ）で表される。
(Thiourea)
The thiourea compound obtained by the production method of the present invention is represented by the following formula (B).
式（Ｂ）中、Ｒは式（Ａ）と同じである。 In formula (B), R is the same as formula (A).
（反応）
反応は、アミン体（Ａ）を、二硫化炭素およびイミダゾールの存在下、溶媒中で反応させることにより行うことができる。ここで、アミン体（Ａ）と二硫化炭素との量比は反応が進行する範囲で適宜設定すればよく、アミン体（Ａ）１当量に対して二硫化炭素２当量以上であれば、十分に反応が進行する。また、上限も特にないが、コストとの兼ね合いから、１０当量以下程度までとすればよい。アミン体とイミダゾールとの量比についても同様に反応が進行する範囲で適宜設定すればよく、アミン体（Ａ）１当量に対してイミダゾール２当量以上であれば、十分に反応が進行する。また、上限も特にないが、コストとの兼ね合いから、１０当量以下程度までとすればよい。
反応温度は２５〜１５０℃の範囲が選択される。２５℃よりも低いと反応性が低く、十分な収率が得られない場合がある。また１５０℃よりも高いと、分解反応など本来の反応とは異なる副反応が併発する場合がある。かかる観点より、上記基準において、好ましくは５０〜１００℃、さらに好ましくは７０〜９０℃の範囲である。反応は常圧で十分進行するが、加圧条件下で反応してもよい。
(reaction)
The reaction can be carried out by reacting the amine body (A) in a solvent in the presence of carbon disulfide and imidazole. Here, the amount ratio of the amine body (A) and carbon disulfide may be appropriately set within a range in which the reaction proceeds, and it is sufficient if the carbon dioxide disulfide is 2 equivalents or more per 1 equivalent of the amine body (A). The reaction proceeds. Moreover, although there is no upper limit in particular, it may be set to about 10 equivalents or less in consideration of cost. Similarly, the amount ratio of the amine body and imidazole may be appropriately set within the range in which the reaction proceeds, and the reaction proceeds sufficiently if it is 2 equivalents or more of imidazole to 1 equivalent of the amine body (A). Moreover, although there is no upper limit in particular, it may be set to about 10 equivalents or less in consideration of cost.
The reaction temperature is selected in the range of 25 to 150 ° C. When it is lower than 25 ° C., the reactivity is low, and a sufficient yield may not be obtained. On the other hand, when the temperature is higher than 150 ° C., side reactions different from the original reactions such as decomposition reactions may occur at the same time. From this viewpoint, in the above criteria, the temperature is preferably in the range of 50 to 100 ° C, more preferably 70 to 90 ° C. The reaction proceeds sufficiently at normal pressure, but may be performed under pressurized conditions.
溶媒としては、メタノール、エタノール、イソプロピルアルコール、ジオキサン、テトラヒドロフラン、酢酸エチル、ジクロロメタン、クロロホルム、Ｎ，Ｎ−ジメチルホルムアミド、メチルエチルケトン、アセトン、トルエン、アセトニトリル等が使用される。反応は上記記載の溶媒で行えるが、得られるチオウレア体の収率および純度の観点から、メチルエチルケトンが好適に使用される。
装置としては、反応で発生する硫化水素を回収する設備を組み合わせた、攪拌および加熱機能を有する反応釜などが使用される。
As the solvent, methanol, ethanol, isopropyl alcohol, dioxane, tetrahydrofuran, ethyl acetate, dichloromethane, chloroform, N, N-dimethylformamide, methyl ethyl ketone, acetone, toluene, acetonitrile and the like are used. Although the reaction can be carried out with the above-mentioned solvents, methyl ethyl ketone is preferably used from the viewpoint of the yield and purity of the resulting thiourea compound.
As the apparatus, a reaction kettle having a stirring and heating function combined with a facility for recovering hydrogen sulfide generated by the reaction is used.
以下本発明を実施例によりさらに説明する。各物性は以下の方法により測定した。 The invention is further illustrated by the following examples. Each physical property was measured by the following methods.
（１）チオウレア体のＮＭＲによる同定：
合成したチオウレア体は１Ｈ−ＮＭＲ、１３Ｃ−ＮＭＲによって確認した。ＮＭＲは日本電子（株）製ＪＮＲ−ＥＸ２７０を使用した。溶媒は重ジメチルスルホキシドを用いた。
（２）チオウレア体の収率：
合成したチオウレア体の収率は、ＮＭＲにより同定されたチオウレア体の乾燥重量を測定し、下記式により求めた。
チオウレア体の収率[％]＝（（チオウレア体乾燥重量／チオウレア体分子量）／アミン体モル数）×１００[％]
(1) NMR identification of thiourea:
The synthesized thiourea product was confirmed by 1 H-NMR and 13 C-NMR. For NMR, JNR-EX270 manufactured by JEOL Ltd. was used. Heavy dimethyl sulfoxide was used as the solvent.
(2) Yield of thiourea compound:
The yield of the synthesized thiourea compound was determined by the following formula by measuring the dry weight of the thiourea compound identified by NMR.
Thiourea yield [%] = ((Thiourea dry weight / Thiourea molecular weight) / Amine mole number) × 100 [%]
［実施例１］チオウレア体Ｔ１の合成：
Ａ１・・・式（Ａ）においてＲ＝Ｈの化合物
Ｔ１・・・式（Ｂ）においてＲ＝Ｈの化合物
攪拌装置および加熱装置、アルカリ水入りウォルターを設置した反応装置に、Ｎ２雰囲気下、下記式で表されるアミン体Ａ１（０．０２５ｍｏｌ）
[Example 1] Synthesis of thiourea compound T1:
A1... Compound with R = H in Formula (A) T1. Compound with R = H in Formula (B) A reactor equipped with a stirrer and a heating device and a Walter containing alkaline water, under an N 2 atmosphere, Amines A1 (0.025 mol) represented by the following formula
とイミダゾール（０．１５ｍｏｌ）、二硫化炭素（０．１５ｍｏｌ）、メチルエチルケトン６０ｍｌを仕込んだ。この反応溶液の温度を８０℃にし、１５時間反応させた。反応後析出した固体をろ過回収し、アセトンで洗浄することで生成回収物が得られた。ＮＭＲにより生成回収物が下記式で表わされるチオウレア体Ｔ１であることが確認された。 And imidazole (0.15 mol), carbon disulfide (0.15 mol), and 60 ml of methyl ethyl ketone were charged. The temperature of the reaction solution was raised to 80 ° C. and reacted for 15 hours. The solid precipitated after the reaction was collected by filtration and washed with acetone to obtain a product recovery product. NMR confirmed that the recovered product was a thiourea T1 represented by the following formula.
チオウレア体Ｔ１の収率は８９．４％であった。 The yield of thiourea T1 was 89.4%.
［比較例１］チオウレア体Ｔ１の合成：
攪拌装置および加熱装置、アルカリ水入りウォルターを設置した反応装置に、Ｎ２雰囲気下、下記式で表されるアミン体Ａ１（０．０２５ｍｏｌ）
[Comparative Example 1] Synthesis of thiourea T1:
In a reactor equipped with a stirrer and a heating device and a Walter containing alkaline water, an amine compound A1 (0.025 mol) represented by the following formula under N 2 atmosphere
とトリエチルアミン（０．２ｍｏｌ）、二硫化炭素（０．２ｍｏｌ）、メチルエチルケトン６０ｍｌを仕込んだ。この反応溶液の温度を８０℃にし、１５時間反応させた。反応後析出した固体をろ過回収し、アセトンで洗浄することで生成回収物が得られた。ＮＭＲにより生成回収物が下記式で表わされるチオウレア体Ｔ１であることが確認された。 And triethylamine (0.2 mol), carbon disulfide (0.2 mol), and 60 ml of methyl ethyl ketone were charged. The temperature of the reaction solution was raised to 80 ° C. and reacted for 15 hours. The solid precipitated after the reaction was collected by filtration and washed with acetone to obtain a product recovery product. NMR confirmed that the recovered product was a thiourea T1 represented by the following formula.
チオウレア体Ｔ１の収率は６６．１％であった。 The yield of thiourea compound T1 was 66.1%.
本発明で得られる式（Ｂ）で表されるチオウレア体は、ポリエステルの末端封止剤として有用な環状カルボジイミド化合物の中間体である。
The thiourea compound represented by the formula (B) obtained in the present invention is an intermediate of a cyclic carbodiimide compound useful as an end-capping agent for polyester.
Claims (2)
The production method according to claim 1, wherein methyl ethyl ketone is used as a reaction solvent.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010137202A JP5604184B2 (en) | 2010-06-16 | 2010-06-16 | Method for producing thiourea compound |
| KR1020127032367A KR20130087387A (en) | 2010-06-16 | 2011-06-15 | Process for production of intermediate for cyclic carbodiimide compound |
| EP11795861.1A EP2583960A4 (en) | 2010-06-16 | 2011-06-15 | Process for production of intermediate for cyclic carbodiimide compound |
| TW100120879A TWI511945B (en) | 2010-06-16 | 2011-06-15 | Preparation of intermediate of cyclic carbodiimide compound |
| CN201180029334.6A CN102933542B (en) | 2010-06-16 | 2011-06-15 | The manufacture method of the intermediate of Cyclic carbodiimide compound |
| PCT/JP2011/064194 WO2011158959A1 (en) | 2010-06-16 | 2011-06-15 | Process for production of intermediate for cyclic carbodiimide compound |
| US13/704,093 US9346826B2 (en) | 2010-06-16 | 2011-06-15 | Process for producing an intermediate for a cyclic carbodiimide compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010137202A JP5604184B2 (en) | 2010-06-16 | 2010-06-16 | Method for producing thiourea compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012001477A true JP2012001477A (en) | 2012-01-05 |
| JP5604184B2 JP5604184B2 (en) | 2014-10-08 |
Family
ID=45533872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010137202A Active JP5604184B2 (en) | 2010-06-16 | 2010-06-16 | Method for producing thiourea compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5604184B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012001476A (en) * | 2010-06-16 | 2012-01-05 | Kawaguchi Kagaku Kogyo Kk | Method for producing carbodiimide compound |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3809692A (en) * | 1971-07-16 | 1974-05-07 | Squibb & Sons Inc | (1,3,5)-thiadiazinobisbenzimidazoles |
| JP2004332166A (en) * | 2003-05-09 | 2004-11-25 | Toray Ind Inc | Polylactic acid fiber |
| JP2005350829A (en) * | 2004-06-14 | 2005-12-22 | Nippon Ester Co Ltd | Polylactic acid fiber having excellent hydrolytic resistance |
| JP2011251967A (en) * | 2008-12-15 | 2011-12-15 | Teijin Ltd | Intermediate for cyclic carbodiimide compound |
-
2010
- 2010-06-16 JP JP2010137202A patent/JP5604184B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3809692A (en) * | 1971-07-16 | 1974-05-07 | Squibb & Sons Inc | (1,3,5)-thiadiazinobisbenzimidazoles |
| JP2004332166A (en) * | 2003-05-09 | 2004-11-25 | Toray Ind Inc | Polylactic acid fiber |
| JP2005350829A (en) * | 2004-06-14 | 2005-12-22 | Nippon Ester Co Ltd | Polylactic acid fiber having excellent hydrolytic resistance |
| JP2011251967A (en) * | 2008-12-15 | 2011-12-15 | Teijin Ltd | Intermediate for cyclic carbodiimide compound |
Non-Patent Citations (1)
| Title |
|---|
| JPN6014032144; ＳＯＵＫＲＩ，Ｍ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ｎｏｖｅｌ ５ａ，１０，１４ｂ，１５-ｔｅｔｒａａｚａ-ｂｅｎｚｏ［ａ］ｉｎｄｅｎｏ［１，２-ｃ］ａｎｔｈｒａｃｅｎ-５-ｏｎｅ ａｎｄ ｂｅｎｚｉｍｉｄａｚｏ［１，２-ｃ］' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４１， Ｎｏ．３１, 2000, ｐ．５８５７-５８６０ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012001476A (en) * | 2010-06-16 | 2012-01-05 | Kawaguchi Kagaku Kogyo Kk | Method for producing carbodiimide compound |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5604184B2 (en) | 2014-10-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011225569A (en) | Aromatic terminal group-bearing amide gelatinizing compound | |
| EP2036899B1 (en) | Method for producing cyclic disulfonic acid ester | |
| US9018398B2 (en) | Intermediate for acenedichalcogenophene derivative and method for synthesizing same | |
| JP5604184B2 (en) | Method for producing thiourea compound | |
| US9346826B2 (en) | Process for producing an intermediate for a cyclic carbodiimide compound | |
| KR102320689B1 (en) | Isocyanuric acid derivative having an alkoxyalkyl group and method for producing the same | |
| KR20180050471A (en) | A method for preparation of (S)-N1-(2-aminoethyl)-3-(4-alkoxyphenyl)propane-1,2-diamine trihydrocholoride | |
| JP5544892B2 (en) | Process for producing 2-cyano-1,3-diketonate salt and ionic liquid | |
| JP2000212132A (en) | Production of quaternary tetraethylammonium chloride | |
| KR101600557B1 (en) | New polyurethane reaction catalyst and synthesizing method thereof | |
| CN112457272B (en) | Preparation method of (3-methoxy-1, 2, 4-thiadiazole-5-amino) phenyl formate | |
| JP5645494B2 (en) | Method for producing amine body | |
| CN109574894B (en) | Synthesis method of N- (3- (dimethylamino) -3-propylsulfonyl) -substituted benzamide (I) | |
| JP5615051B2 (en) | Method for producing carbodiimide body | |
| JP2012036155A (en) | Bis(oxetane vinyl ether) compound, and method for producing the same | |
| JP2017160340A (en) | N, n-dichloro amino modified silicone and method for producing the same, and method for producing cyano modified silicone | |
| JP3905571B2 (en) | Mercapto compounds and process for producing the same | |
| JP5248132B2 (en) | Method for producing calixarene derivative | |
| KR100927242B1 (en) | Allyl allene derivatives and preparation methods thereof | |
| EP2888250A1 (en) | Process for the synthesis of substituted gamma lactams | |
| US20210403417A1 (en) | Process for preparing diisocyanates based on lysine | |
| JPH11152284A (en) | Production of carboxylic acid ester of cyclic phenol sulfide | |
| JP4752121B2 (en) | Method for producing nitrile derivative, intermediate thereof and method for producing intermediate | |
| JP2022029051A (en) | Method for producing thioester derivative | |
| JPS6130580A (en) | Preparation of thiazolidine-2-one |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130521 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140806 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140825 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5604184 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |