JP2011527699A5 - - Google Patents
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- JP2011527699A5 JP2011527699A5 JP2011517621A JP2011517621A JP2011527699A5 JP 2011527699 A5 JP2011527699 A5 JP 2011527699A5 JP 2011517621 A JP2011517621 A JP 2011517621A JP 2011517621 A JP2011517621 A JP 2011517621A JP 2011527699 A5 JP2011527699 A5 JP 2011527699A5
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- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- hydrogen
- formula
- different
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000006239 protecting group Chemical group 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 3
- 239000011612 calcitriol Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- AEDMQUAPBVOJNN-UHFFFAOYSA-N [3-[2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl]-1,2,4-oxadiazol-5-yl]methanol Chemical compound O1C(CO)=NC(C=2SC(=NC=2)N2CCC(CC2)OC=2C(=CC=CC=2)C(F)(F)F)=N1 AEDMQUAPBVOJNN-UHFFFAOYSA-N 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000006409 renal osteodystrophy Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000002374 sebum Anatomy 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 230000037393 skin firmness Effects 0.000 claims 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
- PUPMEPQKWQUIDD-ZIARKUSISA-N CC(C)C/C=C/[C@H](C)[C@@H](CC1)[C@@](C)(CCC2)[C@]1(C)/C2=C/C=C(C[C@H](C1=C)O)C[C@H]1O Chemical compound CC(C)C/C=C/[C@H](C)[C@@H](CC1)[C@@](C)(CCC2)[C@]1(C)/C2=C/C=C(C[C@H](C1=C)O)C[C@H]1O PUPMEPQKWQUIDD-ZIARKUSISA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/171,120 US8399439B2 (en) | 2008-07-10 | 2008-07-10 | 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs |
| US12/171,120 | 2008-07-10 | ||
| PCT/US2009/050106 WO2010006169A2 (en) | 2008-07-10 | 2009-07-09 | 2-methylene-19, 26-dinor-(20s, 22e, 25r)-vitamin d analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011527699A JP2011527699A (ja) | 2011-11-04 |
| JP2011527699A5 true JP2011527699A5 (https=) | 2012-08-23 |
Family
ID=41382534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517621A Pending JP2011527699A (ja) | 2008-07-10 | 2009-07-09 | ２−メチレン−１９，２６−ジノル−（２０ｓ，２２ｅ，２５ｒ）−ビタミンｄ類似物質 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8399439B2 (https=) |
| EP (1) | EP2315745A2 (https=) |
| JP (1) | JP2011527699A (https=) |
| AU (1) | AU2009268505B2 (https=) |
| CA (1) | CA2730257A1 (https=) |
| WO (1) | WO2010006169A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007298651A1 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| AU2011232633B2 (en) * | 2010-03-23 | 2014-05-29 | Wisconsin Alumni Research Foundation | (20S)-2-methylene-19-nor-22-dimethyl-1alpha,25- dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22- dimethyl-1alpha,25-hydroxyvitamin D3 |
| JP5931845B2 (ja) * | 2010-03-23 | 2016-06-08 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１９−ノル−２２−メチル−１α，２５−ジヒドロキシビタミンＤ３のジアステレオマー |
| JP6035331B2 (ja) * | 2011-06-14 | 2016-11-30 | ウイスコンシン アラムニ リサーチ ファンデーション | ３−デスオキシ−２−メチレン−１９−ノル−ビタミンｄ類似体およびそれらの使用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| GB9214202D0 (en) | 1992-07-03 | 1992-08-12 | Leo Pharm Prod Ltd | Chemical compounds |
| DE69400495T2 (de) | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| DK0717034T3 (da) | 1994-12-14 | 1999-10-18 | Duphar Int Res | Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser |
| US5843928A (en) | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| GB9721156D0 (en) | 1997-10-06 | 1997-12-03 | Leo Pharm Prod Ltd | Novel vitamin d analogues |
| WO2002020021A1 (en) | 2000-09-08 | 2002-03-14 | Wisconsin Alumni Research Foundation | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| US6627622B2 (en) | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| AU2004266706B2 (en) * | 2003-08-20 | 2009-07-30 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin D2 compounds |
| CA2544502A1 (en) * | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Vitamin d analogs for obesity prevention and treatment |
| AU2005309804B9 (en) | 2004-11-22 | 2011-12-08 | Wisconsin Alumni Research Foundation | 2alpha-methyl-19-nor-(20S)-1alpha-hydroxy-bishomopregnacalciferol and its uses |
| JP2008520689A (ja) | 2004-11-22 | 2008-06-19 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | １９，２６，２７−トリノル−（２０Ｓ）−１α−ヒドロキシビタミンＤ３の２α−メチルおよび２β−メチル類似体およびそれらの使用 |
| ATE467614T1 (de) | 2004-11-22 | 2010-05-15 | Wisconsin Alumni Res Found | 2-methylen-19,26,27-trinor-(20s)-1-alpha- hydroxyvitamin d3 and dessen verwendungen |
| US7803789B2 (en) | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
| US7528122B2 (en) | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| MX2008012671A (es) | 2006-04-06 | 2008-10-15 | Wisconsin Alumni Res Found | Analogos 1 a,25-dihidroxi- 19, 26,27-trinor vitamina d 2-sustituidos y sus usos. |
| ATE552238T1 (de) | 2006-09-28 | 2012-04-15 | Wisconsin Alumni Res Found | 2-methylen-(20s,25s)-19,27-dinor-(22e)-vitamin- - analoga |
| MX2009003241A (es) * | 2006-09-28 | 2009-05-05 | Wisconsin Alumni Res Found | Analogos de 2-metilen-(20r,25s)-19,27-dinor-(22e)-vitamina d. |
| EP2240440A2 (en) * | 2007-12-28 | 2010-10-20 | Wisconsin Alumni Research Foundation | 2-methylene-(20s,25s)-19,26-dinor-vitamin d analogs |
-
2008
- 2008-07-10 US US12/171,120 patent/US8399439B2/en not_active Expired - Fee Related
-
2009
- 2009-07-09 JP JP2011517621A patent/JP2011527699A/ja active Pending
- 2009-07-09 CA CA2730257A patent/CA2730257A1/en not_active Abandoned
- 2009-07-09 WO PCT/US2009/050106 patent/WO2010006169A2/en not_active Ceased
- 2009-07-09 AU AU2009268505A patent/AU2009268505B2/en not_active Ceased
- 2009-07-09 EP EP09790222A patent/EP2315745A2/en not_active Withdrawn