JP2011520844A

JP2011520844A - 固相合成法により調製されたペプチドの精製

固相合成法により調製されたペプチドの精製 Download PDF

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Publication number: JP2011520844A
Authority: JP; Japan
Prior art keywords: glp; peptide; propionyl; butanoyl; solid phase
Prior art date: 2008-05-15
Legal status : Withdrawn

Application number

JP2011508936A

Other languages

English (en)

Japanese (ja)

Other versions

JP2011520844A5 (enExample

Inventor

カミラコルンベック，

トマス，ブッデハンセン，

Original Assignee

ノボ・ノルデイスク・エー／エス

Priority date

2008-05-15

Filing date

2009-05-15

Publication date

2011-07-21

2009-05-15 Application filed by ノボ・ノルデイスク・エー／エス filed Critical ノボ・ノルデイスク・エー／エス

2011-07-21 Publication of JP2011520844A publication Critical patent/JP2011520844A/ja

2012-07-05 Publication of JP2011520844A5 publication Critical patent/JP2011520844A5/ja

Status Withdrawn legal-status Critical Current

Links

108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 111
102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 24
238000010532 solid phase synthesis reaction Methods 0.000 title claims description 11
238000000746 purification Methods 0.000 title description 12
238000000034 method Methods 0.000 claims abstract description 84
238000010647 peptide synthesis reaction Methods 0.000 claims abstract description 25
239000007790 solid phase Substances 0.000 claims abstract description 23
-1 polyethylene Polymers 0.000 claims description 213
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 96
108010088406 Glucagon-Like Peptides Proteins 0.000 claims description 39
239000000872 buffer Substances 0.000 claims description 27
239000000284 extract Substances 0.000 claims description 24
239000007787 solid Substances 0.000 claims description 23
239000005022 packaging material Substances 0.000 claims description 19
229920001184 polypeptide Polymers 0.000 claims description 17
ZYASLTYCYTYKFC-UHFFFAOYSA-N 9-methylidenefluorene Chemical compound C1=CC=C2C(=C)C3=CC=CC=C3C2=C1 ZYASLTYCYTYKFC-UHFFFAOYSA-N 0.000 claims description 16
239000004698 Polyethylene Substances 0.000 claims description 15
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JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims description 7
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