JP2011520465A5 - - Google Patents
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- Publication number
- JP2011520465A5 JP2011520465A5 JP2011510505A JP2011510505A JP2011520465A5 JP 2011520465 A5 JP2011520465 A5 JP 2011520465A5 JP 2011510505 A JP2011510505 A JP 2011510505A JP 2011510505 A JP2011510505 A JP 2011510505A JP 2011520465 A5 JP2011520465 A5 JP 2011520465A5
- Authority
- JP
- Japan
- Prior art keywords
- human mammal
- genome
- disruption
- transgenic non
- gpr101
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000009261 transgenic effect Effects 0.000 claims 20
- 101150089560 GPR101 gene Proteins 0.000 claims 16
- 101100449163 Homo sapiens GPR101 gene Proteins 0.000 claims 16
- 238000000034 method Methods 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 230000006801 homologous recombination Effects 0.000 claims 7
- 238000002744 homologous recombination Methods 0.000 claims 7
- 230000008685 targeting Effects 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 6
- 230000037396 body weight Effects 0.000 claims 5
- 230000037406 food intake Effects 0.000 claims 5
- 235000012631 food intake Nutrition 0.000 claims 5
- 101001070479 Homo sapiens Probable G-protein coupled receptor 101 Proteins 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 102100034137 Probable G-protein coupled receptor 101 Human genes 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 210000001671 embryonic stem cell Anatomy 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12811008P | 2008-05-19 | 2008-05-19 | |
| US61/128,110 | 2008-05-19 | ||
| PCT/US2009/003094 WO2009142724A2 (en) | 2008-05-19 | 2009-05-18 | Novel gpr101 transgenic mice and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011520465A JP2011520465A (ja) | 2011-07-21 |
| JP2011520465A5 true JP2011520465A5 (https=) | 2012-06-28 |
Family
ID=41010556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510505A Withdrawn JP2011520465A (ja) | 2008-05-19 | 2009-05-18 | 新規ｇｐｒ１０１トランスジェニックマウスおよびそれを使用する方法 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2303002A2 (https=) |
| JP (1) | JP2011520465A (https=) |
| WO (1) | WO2009142724A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007142979A2 (en) | 2006-05-31 | 2007-12-13 | Arena Pharmaceuticals, Inc. | Use of gpr101 receptor in methods to identify modulators of hypothalamic proopiomelanocortin (pomc)-derived biologically active peptide secretion useful in the treatment of pomc-derived biologically active peptide-related disorders |
| US20110173706A1 (en) * | 2008-05-19 | 2011-07-14 | Beth Israel Deaconess Medical Center, Inc. | Novel gpr101 transgenic mice and methods of use thereof |
| EP2918166A1 (en) | 2014-03-10 | 2015-09-16 | Westfälische Wilhelms-Universität Münster | TTP/MRP14 double knock out mouse model of psoriasis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| AU764310B2 (en) | 1999-07-15 | 2003-08-14 | Solvay Pharmaceuticals B.V. | Human G-protein coupled receptor |
| CA2388227A1 (en) | 1999-10-05 | 2001-04-12 | Japan Science And Technology Corporation | A human gene over-expressing animal and test methods using the animal |
| DE10004930A1 (de) | 2000-02-04 | 2001-08-09 | Michael Brues | Seralpha: Gen, cDNA, Expression, Aminosäuresequenz |
| GB2367295A (en) | 2000-06-16 | 2002-04-03 | Smithkline Beecham Corp | AXOR69 polypeptides and polynucleotides |
| US20060123502A1 (en) | 2004-12-03 | 2006-06-08 | Murphy Andrew J | Assay methods for identifying RE2-like antagonists, methods of use, and non-human transgenic animals |
| WO2007142979A2 (en) | 2006-05-31 | 2007-12-13 | Arena Pharmaceuticals, Inc. | Use of gpr101 receptor in methods to identify modulators of hypothalamic proopiomelanocortin (pomc)-derived biologically active peptide secretion useful in the treatment of pomc-derived biologically active peptide-related disorders |
-
2009
- 2009-05-18 JP JP2011510505A patent/JP2011520465A/ja not_active Withdrawn
- 2009-05-18 EP EP09750955A patent/EP2303002A2/en not_active Withdrawn
- 2009-05-18 WO PCT/US2009/003094 patent/WO2009142724A2/en not_active Ceased
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