JP2011518109A - 抗菌剤としてのテトラヒドロ−イソキノリンｐｐａｔ阻害剤 - Google Patents

抗菌剤としてのテトラヒドロ−イソキノリンｐｐａｔ阻害剤 Download PDF

Info

Publication number
JP2011518109A
JP2011518109A JP2010536184A JP2010536184A JP2011518109A JP 2011518109 A JP2011518109 A JP 2011518109A JP 2010536184 A JP2010536184 A JP 2010536184A JP 2010536184 A JP2010536184 A JP 2010536184A JP 2011518109 A JP2011518109 A JP 2011518109A
Authority
JP
Japan
Prior art keywords
independently
alkyl
aryl
aralkyl
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010536184A
Other languages
English (en)
Japanese (ja)
Inventor
フレシェッテ，ロジャー
Original Assignee
ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド filed Critical ビオタ サイエンティフィック マネージメント ピーティーワイ リミテッド
Publication of JP2011518109A publication Critical patent/JP2011518109A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010536184A 2007-11-30 2008-11-26 抗菌剤としてのテトラヒドロ−イソキノリンｐｐａｔ阻害剤 Pending JP2011518109A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99152507P 2007-11-30 2007-11-30
US60/991,525 2007-11-30
PCT/US2008/084948 WO2009073545A2 (fr) 2007-11-30 2008-11-26 Inhibiteurs tétrahydro-isoquinolino de ppat utilisés en tant qu'agents antibactériens

Publications (1)

Publication Number Publication Date
JP2011518109A true JP2011518109A (ja) 2011-06-23

Family

ID=40718459

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010536184A Pending JP2011518109A (ja) 2007-11-30 2008-11-26 抗菌剤としてのテトラヒドロ−イソキノリンｐｐａｔ阻害剤

Country Status (6)

Country Link
EP (1) EP2225207A2 (fr)
JP (1) JP2011518109A (fr)
CN (1) CN102007101A (fr)
AU (1) AU2008334075A1 (fr)
CA (1) CA2707445A1 (fr)
WO (1) WO2009073545A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2225250A2 (fr) 2007-11-30 2010-09-08 Biota Scientific Management Pty Ltd Inhibiteurs de ppat bicycliques utilisés en tant qu'agents antibactériens
FR2986002B1 (fr) 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN102603755B (zh) * 2012-02-08 2015-09-09 中国人民解放军第二军医大学 一类具有协同氟康唑抗耐药真菌作用的化合物
FR3008975A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008977A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008976A1 (fr) 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
JP6633618B2 (ja) 2014-08-21 2020-01-22 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 強力なｒｏｃｋ阻害剤としてのタイドバックのベンズアミド誘導体
EP3334715B1 (fr) * 2015-08-12 2019-05-22 Syngenta Participations AG Dérivés hétérobicycliques microbiocides
CN113461699B (zh) * 2021-04-14 2022-06-21 宁波大学 一种四环吡咯生物碱类化合物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002540206A (ja) * 1999-03-11 2002-11-26 ニューロゲン コーポレイション アリールの縮合した２，４−二置換ピリジン：ｎｋ３受容体リガンド
US20050070570A1 (en) * 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
EP1637529A1 (fr) * 2004-09-20 2006-03-22 4Sc Ag Nouveaux analogues de piperidin-4-yl-thiazole-carboxamide en tant qu'inhibiteurs de proliferation de lymphocytes T er leurs utilisations
WO2007104557A2 (fr) * 2006-03-15 2007-09-20 4Sc Ag Nouveaux inhibiteurs hétérocycliques de nf/kb

Also Published As

Publication number Publication date
EP2225207A2 (fr) 2010-09-08
WO2009073545A3 (fr) 2009-09-11
CA2707445A1 (fr) 2009-06-11
AU2008334075A1 (en) 2009-06-11
CN102007101A (zh) 2011-04-06
WO2009073545A2 (fr) 2009-06-11

Similar Documents

Publication Publication Date Title
JP2011518109A (ja) 抗菌剤としてのテトラヒドロ−イソキノリンｐｐａｔ阻害剤
US10493071B2 (en) Use of pyrroloquinoline compounds to kill clinically latent microorganisms
JP2021513534A (ja) 抗癌剤として有用なテトラヒドロキナゾリン誘導体
EP2609082B1 (fr) Imidazo[4,5-c]quinolines utilisés en tant qu'inhibiteurs d'adn-pk
US20100093691A1 (en) Topical formulations
NO327312B1 (no) Gyraseinhibitorer og anvendelser derav
JP2011505373A (ja) 抗菌剤としての２環式ｐｐａｔ阻害剤
EP1628977B1 (fr) DERIVES DE TETRAHYDRO-b-CARBOLINE ANTIBIOTIQUES
JP2011518108A (ja) 抗菌性テトラヒドロ−β−カルボリン誘導体
KR102276340B1 (ko) 신규한 헤테로고리 화합물
JP2007513055A (ja) 抗菌性シクロアルキルテトラヒドロキノリン誘導体
WO2004064837A1 (fr) Antibacterien inhibiteur du fab i
US20090203726A1 (en) Substituted tetrahydroquinolines as antibacterial agents