JP2011510092A5 - - Google Patents
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- Publication number
- JP2011510092A5 JP2011510092A5 JP2010544419A JP2010544419A JP2011510092A5 JP 2011510092 A5 JP2011510092 A5 JP 2011510092A5 JP 2010544419 A JP2010544419 A JP 2010544419A JP 2010544419 A JP2010544419 A JP 2010544419A JP 2011510092 A5 JP2011510092 A5 JP 2011510092A5
- Authority
- JP
- Japan
- Prior art keywords
- volatile anesthetic
- composition
- solution
- group
- isoflurane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 247
- 239000003983 inhalation anesthetic agent Substances 0.000 claims description 177
- 239000000203 mixture Substances 0.000 claims description 158
- 239000000243 solution Substances 0.000 claims description 66
- 208000002193 Pain Diseases 0.000 claims description 55
- 239000000839 emulsion Substances 0.000 claims description 53
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 claims description 46
- 229960002725 isoflurane Drugs 0.000 claims description 46
- 230000036407 pain Effects 0.000 claims description 45
- 239000000725 suspension Substances 0.000 claims description 41
- 239000002904 solvent Substances 0.000 claims description 39
- 238000000605 extraction Methods 0.000 claims description 29
- RFKMCNOHBTXSMU-UHFFFAOYSA-N methoxyflurane Chemical compound COC(F)(F)C(Cl)Cl RFKMCNOHBTXSMU-UHFFFAOYSA-N 0.000 claims description 25
- 229960002455 methoxyflurane Drugs 0.000 claims description 25
- 229960002078 sevoflurane Drugs 0.000 claims description 25
- DFEYYRMXOJXZRJ-UHFFFAOYSA-N sevoflurane Chemical compound FCOC(C(F)(F)F)C(F)(F)F DFEYYRMXOJXZRJ-UHFFFAOYSA-N 0.000 claims description 25
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 24
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 20
- DPYMFVXJLLWWEU-UHFFFAOYSA-N desflurane Chemical compound FC(F)OC(F)C(F)(F)F DPYMFVXJLLWWEU-UHFFFAOYSA-N 0.000 claims description 20
- 229960003537 desflurane Drugs 0.000 claims description 20
- JPGQOUSTVILISH-UHFFFAOYSA-N enflurane Chemical compound FC(F)OC(F)(F)C(F)Cl JPGQOUSTVILISH-UHFFFAOYSA-N 0.000 claims description 20
- 229960000305 enflurane Drugs 0.000 claims description 20
- 229960003132 halothane Drugs 0.000 claims description 20
- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 claims description 20
- 229910052724 xenon Inorganic materials 0.000 claims description 20
- 229960004529 xenon Drugs 0.000 claims description 20
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims description 20
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 15
- 150000003904 phospholipids Chemical class 0.000 claims description 14
- 238000007918 intramuscular administration Methods 0.000 claims description 11
- 238000007913 intrathecal administration Methods 0.000 claims description 11
- 210000005036 nerve Anatomy 0.000 claims description 11
- 238000007920 subcutaneous administration Methods 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 10
- 239000002502 liposome Substances 0.000 claims description 10
- 210000002200 mouth mucosa Anatomy 0.000 claims description 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
- 238000001990 intravenous administration Methods 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 230000008595 infiltration Effects 0.000 claims description 6
- 238000001764 infiltration Methods 0.000 claims description 6
- MEJYDZQQVZJMPP-ULAWRXDQSA-N (3s,3ar,6r,6ar)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan Chemical compound CO[C@H]1CO[C@@H]2[C@H](OC)CO[C@@H]21 MEJYDZQQVZJMPP-ULAWRXDQSA-N 0.000 claims description 5
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 5
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 5
- 230000000087 stabilizing effect Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 26
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 25
- 239000011780 sodium chloride Substances 0.000 description 21
- 239000003995 emulsifying agent Substances 0.000 description 18
- 150000002632 lipids Chemical class 0.000 description 18
- 230000005764 inhibitory process Effects 0.000 description 15
- 230000007659 motor function Effects 0.000 description 15
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 14
- 229920000858 Cyclodextrin Polymers 0.000 description 10
- 102000008100 Human Serum Albumin Human genes 0.000 description 10
- 108091006905 Human Serum Albumin Proteins 0.000 description 10
- 239000002504 physiological saline solution Substances 0.000 description 10
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 235000012424 soybean oil Nutrition 0.000 description 6
- 239000003549 soybean oil Substances 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 230000002459 sustained effect Effects 0.000 description 6
- 208000000094 Chronic Pain Diseases 0.000 description 5
- 208000005298 acute pain Diseases 0.000 description 5
- 230000003444 anaesthetic effect Effects 0.000 description 5
- 150000002170 ethers Chemical class 0.000 description 5
- 238000001802 infusion Methods 0.000 description 5
- 230000037324 pain perception Effects 0.000 description 5
- 230000000737 periodic effect Effects 0.000 description 5
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- MWRBNPKJOOWZPW-CLFAGFIQSA-N dioleoyl phosphatidylethanolamine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC MWRBNPKJOOWZPW-CLFAGFIQSA-N 0.000 description 3
- 229940035674 anesthetics Drugs 0.000 description 2
- 239000003193 general anesthetic agent Substances 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 238000000527 sonication Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1189808P | 2008-01-22 | 2008-01-22 | |
| US61/011,898 | 2008-01-22 | ||
| PCT/US2009/031707 WO2009094460A2 (en) | 2008-01-22 | 2009-01-22 | Volatile anesthetic compositions and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014174830A Division JP5952357B2 (ja) | 2008-01-22 | 2014-08-29 | 揮発性麻酔薬組成物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510092A JP2011510092A (ja) | 2011-03-31 |
| JP2011510092A5 true JP2011510092A5 (enExample) | 2012-01-05 |
| JP5835542B2 JP5835542B2 (ja) | 2015-12-24 |
Family
ID=40901623
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544419A Expired - Fee Related JP5835542B2 (ja) | 2008-01-22 | 2009-01-22 | 揮発性麻酔薬組成物およびその使用 |
| JP2014174830A Expired - Fee Related JP5952357B2 (ja) | 2008-01-22 | 2014-08-29 | 揮発性麻酔薬組成物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014174830A Expired - Fee Related JP5952357B2 (ja) | 2008-01-22 | 2014-08-29 | 揮発性麻酔薬組成物およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20110159078A1 (enExample) |
| EP (1) | EP2244783B1 (enExample) |
| JP (2) | JP5835542B2 (enExample) |
| CN (1) | CN102006903A (enExample) |
| AU (1) | AU2009206391A1 (enExample) |
| CA (1) | CA2712516C (enExample) |
| DK (1) | DK2244783T3 (enExample) |
| ES (1) | ES2765007T3 (enExample) |
| PL (1) | PL2244783T3 (enExample) |
| WO (1) | WO2009094460A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2081562B1 (en) | 2006-09-20 | 2016-02-24 | The Board of Regents of The University of Texas System | Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief |
| WO2009094459A1 (en) | 2008-01-22 | 2009-07-30 | The Board Of Regents Of The University Of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
| PL2244783T3 (pl) * | 2008-01-22 | 2020-08-24 | Board Of Regents, The University Of Texas System | Kompozycje lotnego anestetyku i sposoby stosowania |
| WO2010025505A1 (en) * | 2008-09-04 | 2010-03-11 | Phebra Pty Ltd | Analgesia by transmucosal administration |
| JP2012526133A (ja) * | 2009-05-05 | 2012-10-25 | ベイポジェニックス インコーポレイテッド | 炎症を低減させるための新規揮発性麻酔薬製剤およびその使用法 |
| EP2345427A1 (de) * | 2010-01-14 | 2011-07-20 | SapioTec GmbH | Flurankomplex |
| DE102010042615A1 (de) | 2010-10-19 | 2012-04-19 | Wacker Chemie Ag | 1:1, 2:1- oder 3:1-Komplex bestehend aus einem Cyclodextrin oder Cyclodextrinderivat und einem halogeniertem Ether, seine Herstellung und seine Verwendung als Schlafmittel |
| WO2012174649A1 (en) * | 2011-06-20 | 2012-12-27 | Dmf Medical Incorporated | An anesthetic circuit and a method for using the anesthetic circuit |
| US9968540B2 (en) * | 2011-06-24 | 2018-05-15 | Vapogenix, Inc. | Formulations and methods for treating dermatological disorders or diseases |
| GB201116271D0 (en) * | 2011-09-21 | 2011-11-02 | Univ Cardiff | Dispersion anaesthetic device |
| US11083696B2 (en) * | 2011-09-21 | 2021-08-10 | University College Cardiff Consultants Limited | Dispersion anaesthetic device |
| WO2014094139A1 (en) | 2012-12-22 | 2014-06-26 | Dmf Medical Incorporated | An anesthetic circuit having a hollow fiber membrane |
| CN113712911A (zh) * | 2013-03-15 | 2021-11-30 | 维普詹尼克斯公司 | 新型镇痛组合物 |
| US10213574B2 (en) | 2015-07-20 | 2019-02-26 | Medical Developments International Limited | Inhaler device for inhalable liquids |
| US20180207370A1 (en) | 2015-07-20 | 2018-07-26 | Medical Developments International Limited | Inhaler device for inhalable liquids |
| AU2016295425B2 (en) | 2015-07-20 | 2020-09-24 | Medical Developments International Limited | Inhaler device for inhalable liquids |
| CN109803702B (zh) | 2016-09-06 | 2022-04-12 | 医疗发展国际有限公司 | 用于可吸入液体的吸入器装置 |
| WO2019183130A1 (en) * | 2018-03-19 | 2019-09-26 | Trustees Of Boston University | Systems, devices, and methods for ultrasonic agitation mediated kinetic release testing of compounds |
| CN115843263B (zh) | 2020-06-02 | 2025-07-04 | 医疗发展国际有限公司 | 用于可吸入液体的吸入器装置 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4879062A (en) * | 1981-10-20 | 1989-11-07 | Adamantech, Inc. | Preparation of a gel having gas transporting capability |
| US4622219A (en) | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
| US4725442A (en) * | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
| US4744989A (en) * | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
| US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US5114714A (en) | 1990-11-29 | 1992-05-19 | Sepracor, Inc. | Methods of use and compositions of (r)-isoflurane and (r)-desflurane |
| US5114715A (en) | 1990-11-29 | 1992-05-19 | Sepracor Inc. | Methods of use and compositions of (s)-isoflurane and (s)-desflurane |
| US5416071A (en) * | 1991-03-12 | 1995-05-16 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release containing epo and hyaluronic acid |
| BE1005163A3 (fr) | 1991-08-01 | 1993-05-11 | Solvay | Compositions contenant un ether fluore et utilisation de ces compositions. |
| US5283372A (en) | 1991-12-04 | 1994-02-01 | Anaquest, Inc. | Preparation of purified optical isomers of desflurane |
| US5230778A (en) | 1992-05-01 | 1993-07-27 | Gavlin Associates | Purification of isoflurane by extractive distillation |
| US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| HUP9900879A2 (hu) * | 1995-06-07 | 1999-08-30 | Alliance Pharmaceutical Corp. | Fordított fluor-szénhidrogén emulziós készítmények gyógyszeradagoláshoz |
| US5874469A (en) * | 1996-01-05 | 1999-02-23 | Alcon Laboratories, Inc. | Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs |
| US5861175A (en) * | 1996-03-15 | 1999-01-19 | Alliance Pharmaceutical Corp. | Use of fluorocarbons for diagnosis and treatment of articular disorders |
| DE19709704C2 (de) | 1997-03-10 | 1999-11-04 | Michael Georgieff | Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie |
| US20030185761A1 (en) | 1997-10-01 | 2003-10-02 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
| US20050287075A1 (en) * | 1997-10-01 | 2005-12-29 | Dugger Harry A Iii | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
| GB2350297A (en) * | 1999-05-27 | 2000-11-29 | Abbott Lab | Injectable halogenated anesthetic formulation in emulsion form |
| US6673363B2 (en) * | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
| WO2002058670A1 (en) * | 2001-01-25 | 2002-08-01 | Euroceltique S.A. | Local anesthetic, and method of use |
| WO2002089849A1 (en) * | 2001-05-07 | 2002-11-14 | Corium International | Compositions and delivery systems for administration of a local anesthetic agent |
| KR20120030598A (ko) * | 2002-10-11 | 2012-03-28 | 백스터 인터내셔널 인코포레이티드 | 할로겐화된 휘발성 마취제의 정맥내 투여에 의한 심장보호 및 신경보호방법 |
| CA2530407A1 (en) * | 2003-07-23 | 2005-02-03 | The Regents Of The University Of California | Penetration enhancer combinations for transdermal delivery |
| AU2004280118B2 (en) * | 2003-10-10 | 2009-01-15 | Imperial Innovations Limited | Use of xenon with hypothermia for treating neonatal asphyxia |
| US8557861B2 (en) * | 2004-09-28 | 2013-10-15 | Mast Therapeutics, Inc. | Low oil emulsion compositions for delivering taxoids and other insoluble drugs |
| US20060198891A1 (en) * | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
| EP2081562B1 (en) | 2006-09-20 | 2016-02-24 | The Board of Regents of The University of Texas System | Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief |
| US9000048B2 (en) * | 2006-11-28 | 2015-04-07 | Wisconsin Alumni Research Foundation | Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics |
| PL2244783T3 (pl) * | 2008-01-22 | 2020-08-24 | Board Of Regents, The University Of Texas System | Kompozycje lotnego anestetyku i sposoby stosowania |
| WO2009094459A1 (en) * | 2008-01-22 | 2009-07-30 | The Board Of Regents Of The University Of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
| JP2012526133A (ja) | 2009-05-05 | 2012-10-25 | ベイポジェニックス インコーポレイテッド | 炎症を低減させるための新規揮発性麻酔薬製剤およびその使用法 |
-
2009
- 2009-01-22 PL PL09704014T patent/PL2244783T3/pl unknown
- 2009-01-22 WO PCT/US2009/031707 patent/WO2009094460A2/en not_active Ceased
- 2009-01-22 CN CN2009801108275A patent/CN102006903A/zh active Pending
- 2009-01-22 DK DK09704014.1T patent/DK2244783T3/da active
- 2009-01-22 EP EP09704014.1A patent/EP2244783B1/en active Active
- 2009-01-22 AU AU2009206391A patent/AU2009206391A1/en not_active Abandoned
- 2009-01-22 US US12/863,757 patent/US20110159078A1/en not_active Abandoned
- 2009-01-22 CA CA2712516A patent/CA2712516C/en not_active Expired - Fee Related
- 2009-01-22 ES ES09704014T patent/ES2765007T3/es active Active
- 2009-01-22 JP JP2010544419A patent/JP5835542B2/ja not_active Expired - Fee Related
-
2012
- 2012-12-20 US US13/722,880 patent/US9566251B2/en not_active Expired - Fee Related
-
2014
- 2014-08-29 JP JP2014174830A patent/JP5952357B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-03 US US15/397,698 patent/US20170112783A1/en not_active Abandoned
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