ES2765007T3 - Composiciones anestésicas volátiles y métodos de uso - Google Patents
Composiciones anestésicas volátiles y métodos de uso Download PDFInfo
- Publication number
- ES2765007T3 ES2765007T3 ES09704014T ES09704014T ES2765007T3 ES 2765007 T3 ES2765007 T3 ES 2765007T3 ES 09704014 T ES09704014 T ES 09704014T ES 09704014 T ES09704014 T ES 09704014T ES 2765007 T3 ES2765007 T3 ES 2765007T3
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- Prior art keywords
- volatile anesthetic
- isoflurane
- composition
- pain
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
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- A61K31/075—Ethers or acetals
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Dispersion Chemistry (AREA)
- Psychology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1189808P | 2008-01-22 | 2008-01-22 | |
| PCT/US2009/031707 WO2009094460A2 (en) | 2008-01-22 | 2009-01-22 | Volatile anesthetic compositions and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2765007T3 true ES2765007T3 (es) | 2020-06-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| ES09704014T Active ES2765007T3 (es) | 2008-01-22 | 2009-01-22 | Composiciones anestésicas volátiles y métodos de uso |
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| Country | Link |
|---|---|
| US (3) | US20110159078A1 (enExample) |
| EP (1) | EP2244783B1 (enExample) |
| JP (2) | JP5835542B2 (enExample) |
| CN (1) | CN102006903A (enExample) |
| AU (1) | AU2009206391A1 (enExample) |
| CA (1) | CA2712516C (enExample) |
| DK (1) | DK2244783T3 (enExample) |
| ES (1) | ES2765007T3 (enExample) |
| PL (1) | PL2244783T3 (enExample) |
| WO (1) | WO2009094460A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| PL2081562T3 (pl) | 2006-09-20 | 2017-05-31 | The Board Of Regents Of The University Of Texas System | Sposoby dostarczania lotnych środków znieczulających do znieczulenia regionalnego i/lub zmniejszania bólu |
| PL2244737T3 (pl) * | 2008-01-22 | 2020-05-18 | The Board Of Regents Of The University Of Texas System | Kompozycje lotnego środka znieczulającego zawierające rozpuszczalniki ekstrakcyjne do znieczulania miejscowego i / albo zwalczania bólu |
| AU2009206391A1 (en) * | 2008-01-22 | 2009-07-30 | Board Of Regents, The University Of Texas System | Volatile anesthetic compositions and methods of use |
| WO2010025505A1 (en) * | 2008-09-04 | 2010-03-11 | Phebra Pty Ltd | Analgesia by transmucosal administration |
| WO2010129686A1 (en) * | 2009-05-05 | 2010-11-11 | Vapogenix, Inc. | Novel formulations of volatile anesthetics and methods of use for reducing inflammation |
| EP2345427A1 (de) * | 2010-01-14 | 2011-07-20 | SapioTec GmbH | Flurankomplex |
| DE102010042615A1 (de) | 2010-10-19 | 2012-04-19 | Wacker Chemie Ag | 1:1, 2:1- oder 3:1-Komplex bestehend aus einem Cyclodextrin oder Cyclodextrinderivat und einem halogeniertem Ether, seine Herstellung und seine Verwendung als Schlafmittel |
| EP2720744B1 (en) * | 2011-06-20 | 2017-09-06 | DMF Medical Incorporated | An anesthetic circuit |
| AU2012272933B2 (en) * | 2011-06-24 | 2016-08-11 | Vapogenix, Inc. | Novel formulations and methods for treating dermatological disorders or diseases |
| US11083696B2 (en) * | 2011-09-21 | 2021-08-10 | University College Cardiff Consultants Limited | Dispersion anaesthetic device |
| GB201116271D0 (en) * | 2011-09-21 | 2011-11-02 | Univ Cardiff | Dispersion anaesthetic device |
| US10076620B2 (en) | 2012-12-22 | 2018-09-18 | Dmf Medical Incorporated | Anesthetic circuit having a hollow fiber membrane |
| JP6669645B2 (ja) * | 2013-03-15 | 2020-03-18 | ベイポジェニックス インコーポレイテッド | 新規な鎮痛組成物 |
| US10213574B2 (en) | 2015-07-20 | 2019-02-26 | Medical Developments International Limited | Inhaler device for inhalable liquids |
| EP3325061B1 (en) | 2015-07-20 | 2021-05-05 | Medical Developments International Limited | Inhaler device for inhalable liquids |
| EP3325062A4 (en) | 2015-07-20 | 2019-03-13 | Medical Developments International Limited | INHALER FOR INHALABLE LIQUIDS |
| WO2018045418A1 (en) | 2016-09-06 | 2018-03-15 | Medical Developments International Limited | Inhaler device for inhalable liquids |
| US12480926B2 (en) | 2018-03-19 | 2025-11-25 | Trustees Of Boston University | Systems, devices, and methods for ultrasonic agitation mediated kinetic release testing of compounds |
| CN115843263B (zh) | 2020-06-02 | 2025-07-04 | 医疗发展国际有限公司 | 用于可吸入液体的吸入器装置 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879062A (en) * | 1981-10-20 | 1989-11-07 | Adamantech, Inc. | Preparation of a gel having gas transporting capability |
| US4622219A (en) * | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
| US4725442A (en) * | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
| US4744989A (en) * | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
| US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US5114715A (en) | 1990-11-29 | 1992-05-19 | Sepracor Inc. | Methods of use and compositions of (s)-isoflurane and (s)-desflurane |
| US5114714A (en) | 1990-11-29 | 1992-05-19 | Sepracor, Inc. | Methods of use and compositions of (r)-isoflurane and (r)-desflurane |
| US5416071A (en) * | 1991-03-12 | 1995-05-16 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release containing epo and hyaluronic acid |
| BE1005163A3 (fr) * | 1991-08-01 | 1993-05-11 | Solvay | Compositions contenant un ether fluore et utilisation de ces compositions. |
| US5283372A (en) | 1991-12-04 | 1994-02-01 | Anaquest, Inc. | Preparation of purified optical isomers of desflurane |
| US5230778A (en) * | 1992-05-01 | 1993-07-27 | Gavlin Associates | Purification of isoflurane by extractive distillation |
| US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| JPH11508237A (ja) * | 1995-06-07 | 1999-07-21 | アライアンス ファーマシューティカル コーポレイション | 薬物送達のための逆相フルオロカーボンエマルジョン組成物 |
| US5874469A (en) * | 1996-01-05 | 1999-02-23 | Alcon Laboratories, Inc. | Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs |
| US5861175A (en) * | 1996-03-15 | 1999-01-19 | Alliance Pharmaceutical Corp. | Use of fluorocarbons for diagnosis and treatment of articular disorders |
| DE19709704C2 (de) | 1997-03-10 | 1999-11-04 | Michael Georgieff | Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie |
| US20030185761A1 (en) * | 1997-10-01 | 2003-10-02 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
| US20050287075A1 (en) * | 1997-10-01 | 2005-12-29 | Dugger Harry A Iii | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
| GB2350297A (en) | 1999-05-27 | 2000-11-29 | Abbott Lab | Injectable halogenated anesthetic formulation in emulsion form |
| US6673363B2 (en) * | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
| EP1363602A4 (en) * | 2001-01-25 | 2006-01-11 | Euro Celtique Sa | LOCAL ANESTHESIA, AND METHOD OF USE |
| US20030027833A1 (en) * | 2001-05-07 | 2003-02-06 | Cleary Gary W. | Compositions and delivery systems for administration of a local anesthetic agent |
| ATE546136T1 (de) * | 2002-10-11 | 2012-03-15 | Baxter Int | Kardioprotektions- und neuroprotektionsverfahren durch intravenöse verabreichung von halogenierten flüchtigen narkosemitteln |
| CA2530407A1 (en) * | 2003-07-23 | 2005-02-03 | The Regents Of The University Of California | Penetration enhancer combinations for transdermal delivery |
| MXPA06003471A (es) * | 2003-10-10 | 2006-06-14 | Protexeon Ltd | Uso de xenon con hipotermia para tratar la asfixia neonatal. |
| US8557861B2 (en) * | 2004-09-28 | 2013-10-15 | Mast Therapeutics, Inc. | Low oil emulsion compositions for delivering taxoids and other insoluble drugs |
| US20060198891A1 (en) * | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
| PL2081562T3 (pl) | 2006-09-20 | 2017-05-31 | The Board Of Regents Of The University Of Texas System | Sposoby dostarczania lotnych środków znieczulających do znieczulenia regionalnego i/lub zmniejszania bólu |
| US9000048B2 (en) * | 2006-11-28 | 2015-04-07 | Wisconsin Alumni Research Foundation | Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics |
| PL2244737T3 (pl) * | 2008-01-22 | 2020-05-18 | The Board Of Regents Of The University Of Texas System | Kompozycje lotnego środka znieczulającego zawierające rozpuszczalniki ekstrakcyjne do znieczulania miejscowego i / albo zwalczania bólu |
| AU2009206391A1 (en) * | 2008-01-22 | 2009-07-30 | Board Of Regents, The University Of Texas System | Volatile anesthetic compositions and methods of use |
| WO2010129686A1 (en) | 2009-05-05 | 2010-11-11 | Vapogenix, Inc. | Novel formulations of volatile anesthetics and methods of use for reducing inflammation |
-
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- 2009-01-22 AU AU2009206391A patent/AU2009206391A1/en not_active Abandoned
- 2009-01-22 JP JP2010544419A patent/JP5835542B2/ja not_active Expired - Fee Related
- 2009-01-22 ES ES09704014T patent/ES2765007T3/es active Active
- 2009-01-22 DK DK09704014.1T patent/DK2244783T3/da active
- 2009-01-22 CA CA2712516A patent/CA2712516C/en not_active Expired - Fee Related
- 2009-01-22 PL PL09704014T patent/PL2244783T3/pl unknown
- 2009-01-22 WO PCT/US2009/031707 patent/WO2009094460A2/en not_active Ceased
- 2009-01-22 CN CN2009801108275A patent/CN102006903A/zh active Pending
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2012
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2014
- 2014-08-29 JP JP2014174830A patent/JP5952357B2/ja not_active Expired - Fee Related
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2017
- 2017-01-03 US US15/397,698 patent/US20170112783A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2244783B1 (en) | 2019-12-18 |
| JP5835542B2 (ja) | 2015-12-24 |
| EP2244783A4 (en) | 2011-03-09 |
| CA2712516A1 (en) | 2009-07-30 |
| DK2244783T3 (da) | 2020-03-16 |
| WO2009094460A3 (en) | 2009-12-30 |
| EP2244783A2 (en) | 2010-11-03 |
| JP2011510092A (ja) | 2011-03-31 |
| JP5952357B2 (ja) | 2016-07-13 |
| US20130273141A1 (en) | 2013-10-17 |
| PL2244783T3 (pl) | 2020-08-24 |
| WO2009094460A2 (en) | 2009-07-30 |
| JP2014240420A (ja) | 2014-12-25 |
| US9566251B2 (en) | 2017-02-14 |
| AU2009206391A1 (en) | 2009-07-30 |
| CN102006903A (zh) | 2011-04-06 |
| US20170112783A1 (en) | 2017-04-27 |
| CA2712516C (en) | 2016-06-28 |
| US20110159078A1 (en) | 2011-06-30 |
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