JP2011236167A - Eye-drops and method for producing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide eye-drops and a method for producing the eye-drops composed of minerals as principal components and exhibiting excellent efficacy to relieving symptoms such as eyestrain and dry eyes by paying attention to effect of the minerals.SOLUTION: The method for producing eye-drops includes: a process for preparing mineral water; a process for diluting the mineral water with demineralized water; a process for precipitating impurities in the mineral water during the dilution or after the dilution, preferably by leaving the dilution at rest after heating it to 70°C or higher; and a process for collecting the supernatant obtained by precipitating the impurities. The process for preparing the mineral water includes a process for dissolving granite porphyry or other ores with acetic acid.

Description

  The present invention relates to eye drops and a method for producing the same. More specifically, the present invention is prominent in eyestrain caused by long-term use of a personal computer or the like, dry eye, flying mosquito disease, or a decrease in visual acuity associated with aging. The present invention relates to an ophthalmic solution whose efficacy is recognized and a method for producing the same.

  In recent years, the use of personal computers has increased, and there are an increasing number of people who operate personal computers for a long time regardless of gender. As a result of operating the personal computer for a long time, many people complain of stiff shoulders and eye strain. In addition to the use of personal computers, the use of contact lenses and the spread of air conditioners are increasing the number of people with dry eye symptoms. In general, eye drops containing vitamins, hyaluronic acid and the like are used to relieve such symptoms of eye strain and dry eye.

  However, these vitamins, hyaluronic acid, and the like are originally absorbed into the body by taking them through the mouth and are considered to exert their effects. It is not possible to expect a noticeable effect to relieve eye symptoms. In addition, there are eye drops containing minerals, but as is clear from the fact that the mineral content in that case is small, they are not expected to be effective by paying attention to the effects of minerals.

Special table 2009-515821 Special table 2008-500282 Japanese translation of PCT publication No. 2002-522382

  As described above, no ophthalmic solution has been proposed that is effective in relieving the symptoms of eye strain and dry eye, and particularly focusing on the effects of minerals on these symptoms. Then, this invention pays attention to the effect of a mineral, and has as a subject to provide the eyedrop which has this as a main component, and exhibits the effect excellent in relieving the symptoms of eye strain and dry eye, and its manufacturing method. To do.

  Since human cells are basically minerals, it goes without saying that mineral components are essential for the normal functioning of cells. Therefore, the present inventors have obtained the knowledge that if an eye drop containing a mineral as a main component is used, the mineral component will be absorbed from the eye and will effectively act to alleviate the symptoms of various eye diseases. The present invention has been made.

  That is, the invention according to claim 1 for solving the above-described problem is an eye drop mainly composed of a mineral obtained by diluting mineral water with pure water. In a preferred embodiment, the mineral water is a granite porphyry or other ore dissolved with acetic acid, and further contains physiological saline. In that case, the mineral water, pure water, and physiological water The mixing ratio of the saline is preferably about 0.8 to 1.3: 8.2 to 7.7: 1, more preferably about 1: 8: 1.

  In addition, the invention according to claim 4 for solving the above-described problems includes a step of preparing mineral water, a step of diluting the mineral water with pure water, and heating to a predetermined temperature or higher during or after the dilution. Then, it is allowed to stand and precipitate the impurities in the mineral water, and a method for producing an eye drop comprising the step of collecting the supernatant obtained by precipitating the impurities.

  In a preferred embodiment, the step of preparing the mineral water is a step of dissolving granite porphyry or other ore with acetic acid, and the predetermined temperature is 70 ° C. The method further includes the step of adding physiological saline, in which case the mixing ratio of mineral water, pure water, and physiological saline is preferably about 0.8 to 1.3: 8.2 to 7. 7: 1, more preferably about 1: 8: 1. The step of adding physiological saline is performed after the step of collecting the supernatant.

  The present invention is as described above, and the eye drop according to the present invention is obtained by diluting mineral water obtained by dissolving granite porphyry or other ore with acetic acid with pure water, and adding it to a predetermined temperature or higher during or after the dilution. It is composed mainly of a mineral composed of a supernatant obtained by precipitating after warming and precipitating impurities in mineral water, and is preferably heated to 70 ° C. or more at the time of dilution or after dilution. Since the impurities are precipitated and separated as large crystals, it becomes a clean substance containing only effective mineral components, and there is an effect that eye drops having the effect of sufficiently relieving various eye disease symptoms can be obtained.

  Below, the form for implementing this invention is demonstrated. The eye drop according to the present invention is mainly composed of a mineral obtained by diluting mineral water with pure water, and preferably further contains physiological saline. And, the method according to the present invention for producing the eye drops includes a step of preparing mineral water, a step of diluting the mineral water with pure water, and heating after the dilution or after dilution. The method comprises a step of precipitating impurities in the mineral water, and a step of collecting a supernatant obtained by precipitating the impurities. Below, each process is demonstrated in detail.

  As the mineral water used in the present invention, for example, it is recommended to use a granulated porphyry or other ore extracted from acetic acid. The eye drops according to the present invention are obtained by diluting this mineral water with pure water, and even if used in that state, a certain effect can be expected.

  However, when the mineral water is simply diluted with pure water, the entire liquid begins to become cloudy within a few hours after dilution, and becomes visibly cloudy after a few days. Become. This is presumably due to the inclusion of unnecessary components in addition to effective mineral components in order to extract ores such as granite porphyry from raw materials by dissolving them with acetic acid.

  Even if such an ophthalmic solution with turbidity is effective, it may cause eyelids and sometimes be accompanied by pain. Therefore, as a result of researches to eliminate this turbidity, the present inventors have found that in order to solve the problem of turbidity, it should be allowed to stand after being heated to a predetermined temperature or higher at the time of dilution or after dilution. . The heating temperature is preferably 70 ° C. or higher. Thus, when heated at the time of dilution or after dilution, impurities in the mineral water crystallize within a short time, and then settled to become a solid and precipitate at the bottom of the container. As a result of the impurities being separated in this way, the supernatant liquid becomes very clear, so that the supernatant liquid is recovered.

  The reason why the dilution liquid is heated to 70 ° C. or higher as described above is to precipitate impurities as a large crystal within a relatively short time, for example, when heated to a low temperature of 20 to 30 ° C. Will remain in the liquid as impurities in the micron unit. And if this floating substance is removed using a permeable membrane, there is a possibility that even an effective mineral component may be removed.

  According to the tests by the present inventors, the occurrence of turbidity starts immediately after dilution, and crystallization of impurities becomes remarkable after about 48 hours heated to 70 ° C. or higher, and the supernatant liquid becomes almost transparent after about 10 days. Therefore, the supernatant is collected after that.

  Preferably, physiological saline is added to the supernatant. This is because physiological saline is thought to promote penetration of the active ingredient into the eye. In this case, the mixing ratio of mineral water, pure water, and physiological saline is preferably about 1: 8: 1, but the mineral water has a higher concentration (for example, mineral water: pure water = 1.3). : 7.7), or a lower concentration (for example, mineral water: pure water = 0.8: 8.2).

The following is an example of a mineral composition table (in 100 ml) after adding physiological saline as described above.
Mg 0.029mg
P 0.00013mg
Ca 0.00228mg
Se 0.000001mg
Cu 0.00001mg
Mn 0.00013mg
Na 0.0001mg
Fe 0.00069mg
Mn 0.00013mg
V Trace Mo Trace Other useful mineral Trace Nacl 0.9g

The effectiveness of this eye drop has been confirmed through trials with more than 50 monitors. The following are examples of responses received from monitors for reference.
・ Setagaya-ku Okuzawa 20s male (trademark designer)
I have been using various eye drops so far, but nothing has been so effective.
Although it is dry eye, it is possible to work without problems by using it 5 or 6 times a day.
・ Meguro-ku Yakumo 20s male (self-employed (using computer))
Although I had dry eyes and flying mosquitoes on my job, daily symptoms gave me both symptoms and comfortable work.
・ Female in Meguro Yakumo 40s (company employee (using a computer))
The effect appeared from the start of use, and stiff shoulders due to eye strain, and the back of the neck was always stiff, but by instilling the symptoms alleviated and the stiffness of the neck improved considerably.
・ Female in Setagaya-ku Okuzawa 50s (restaurant)
The presbyopia thought that his visual acuity was unavoidable, but when he applied it, his visual acuity recovered and his eyes looked good. When I asked a senior elderly woman in the neighborhood, he said it would have the same effect.
・ Yokohama City 60s (unemployed)
Although I couldn't take my eye drops all the time, the use of this medicine significantly reduced the symptoms such as dry eye.
・ Setagaya-ku Okusawa 50s (doctor)
The effect was found immediately after use. Although it is dry eye, the symptoms are clearly alleviated. It has been well received by doctors.
・ Ikegami 30s (Setagaya-ku)
I had a lot of eye strain in my computer work, but I feel better.
・ Kawasaki City 60s Female (Housewife)
Until last year, the pollen period in spring was uncomfortable for the eyes, and I used a commercially available eye drop, but there was no improvement at all. No problem with instilling many times in the eyes.
・ Yokohama City 40s female (part-time housewife)
Although eye fatigue was serious in the personal computer business, there was no negative point for work by using this ophthalmic solution. However, although the eyesight recovered considerably after instillation, the dry eye situation remained unchanged.
・ Female, 50s, Kamiikedai, Ota-ku (working at the Embassy)
Since I started taking instillation, my dry eye symptoms have improved considerably even at work on my computer.
The situation continues to be much easier than before. Without this, work is difficult.
・ Toyoaki City, Nagoya City 60s male (engineer)
Immediately after use, you can feel the effect, and now it can not be released.
・ Fuchu City 40s female (foreign car sales)
Until now, I found that my eyes were tired and my vision decreased in the evening using a personal computer.
・ Yokohama City 30s (Automobile Sales)
There are times when I use a computer a lot during my work, and I was troubled with eye fatigue, but using this I can realize the recovery of my vision.

  Although the present invention has been described in some detail with respect to its most preferred embodiments, it will be apparent that a wide variety of different embodiments can be constructed without departing from the spirit and scope of the invention, the invention being defined by the appended claims. It is not restricted to the specific embodiment other than limiting in.

The following is an example of a mineral composition table (in 100 ml) after adding physiological saline as described above.
Mg 0.029mg
P 0.00013mg
Ca 0.00228mg
Se 0.000001mg
Cu 0.00001mg
Mn 0.00013mg
Na 0.0001mg
Fe 0.00069mg
Mn 0.00013mg
V Trace Mo Trace Other useful mineral Trace Nacl 0.09g

The invention according to claim 1 for solving the above-mentioned problems is an eye drop obtained by diluting mineral water obtained by dissolving granite porphyry with acetic acid with pure water and appropriately containing physiological saline. is there. The mixing ratio of mineral water, pure water, and physiological saline is 0.8 to 1.3: 8.2 to 7.7: 1, and preferably 1: 8: 1.

Further, the invention according to claim 4 for solving the above-mentioned problems is a step of dissolving mineral porphyry with acetic acid to obtain mineral water, a step of diluting the mineral water with pure water, and the time of the dilution. Alternatively, the method comprises a step of allowing the impurities in the diluted mineral water to settle after warming to a predetermined temperature or higher after dilution, and a step of recovering a supernatant obtained by precipitating the impurities. And a method for producing eye drops.

In a preferred embodiment, the predetermined temperature is 70 ° C. The method further includes a step of adding physiological saline, in which case the mixing ratio of mineral water, pure water and physiological saline is 0.8 to 1.3: 8.2 to 7.7: 1. Preferably, the ratio is 1: 8: 1. The step of adding physiological saline is performed after the step of collecting the supernatant.

Claims (10)

  Eye drops mainly composed of minerals made by diluting mineral water with pure water.   The eye drop according to claim 1, wherein the mineral water is obtained by dissolving granite porphyry and other ores with acetic acid.   The eye drop according to claim 1 or 2, further comprising physiological saline.   The mixing ratio of the mineral water, the pure water and the physiological saline is about 0.8-1.3: 8.2-7.7: 1, preferably about 1: 8: 1. Item 4. Eyedrops. A process of preparing mineral water;
Diluting the mineral water with pure water;
A step of precipitating impurities in the mineral water by standing after being heated to a predetermined temperature or higher at the time of dilution or after dilution;
And a step of recovering a supernatant obtained by precipitating the impurities.   The method for producing eye drops according to claim 5, wherein the step of preparing the mineral water comprises a step of dissolving granite porphyry or other ores with acetic acid.   The method for producing eye drops according to claim 5, wherein the predetermined temperature is 70 ° C. The method for producing eye drops according to any one of claims 5 to 7, further comprising a step of adding physiological saline.   The method for producing eye drops according to claim 8, wherein the step of adding physiological saline is performed after the step of collecting the supernatant.   The mixing ratio of the mineral water, the pure water, and the physiological saline is about 0.8-1.3: 8.2-7.7: 1, preferably about 1: 8: 1. Item 10. A method for producing an eye drop according to Item 8 or 9.