JP2011209757A - Method and composition for care of contact lens - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a method and a composition for the care of contact lenses, the method and the composition exhibiting an effect of suppressing adhesion of microorganisms.SOLUTION: A method for suppressing adhesion of microorganisms to a contact lens or a contact lens case is provided, characterized by immersing a contact lens for a given time or longer in a composition for the care of contact lenses, the composition containing a polyoxyethylene sorbitan fatty acid ester and a buffer.

Description

  The present invention relates to a method for suppressing microbial adhesion to a contact lens or a contact lens case, and a contact lens care composition used in such a method.

  Wearing contact lenses are exposed to the risk of attachment of microorganisms floating in the air and microorganisms present in the ocular mucosa. In addition, when a wearer handles a contact lens such as attaching or detaching a contact lens, microorganisms on the finger adhere to the contact lens, or microorganisms attached to the contact lens case adhere to the contact lens during storage in the case. Sometimes.

  Since contact lens wearers tend to have dry eyes, there are reports that contact lens wearers have a lot of money due to the environment where microorganisms are likely to adhere to and proliferate. In addition, the attached microorganisms themselves, or the attached proteins and lipids triggered by the attached microorganisms, cause the contact lens to become soiled. However, the contact lens rear surface (corner side) stains give the wearer a strong sense of foreign matter. Or the wearing contact lens may cause fogging. Furthermore, among microorganisms, fungi digest contact lens polymers, aspergillus Aspergillum sp., Penicillium sp. And dermatophyte Tricophyton sp. Adhere to contact lens polymers, causing corrosion and deterioration. It is known that

  Furthermore, since these microorganisms are attached to the contact lens and the lens case surface alone, it is more problematic that a plurality of types of microorganisms form a complex with organic substances derived from these microorganisms. This complex is called a biofilm. Once the biofilm is formed, it cannot be removed by normal contact lens care, and microorganisms that have been gradually killed accumulate, forming a stronger biofilm. Eventually, when the amount of these microorganisms reaches a level that the biological defense system cannot tolerate, an eye infection develops (Non-patent Document 1).

  As described above, it is very important to remove microorganisms in contact lens cases or the like that can supply microorganisms indirectly to the lens, regardless of whether they contain water or not. However, in the method of cleaning and sterilizing microorganisms adhering to the contact lens and the lens case afterwards, the effectiveness of the cleaning and sterilizing components is not sufficiently exhibited by the above-described biofilm formation, so that the microorganisms cannot be sufficiently removed. Therefore, it is more important not only to reduce the number of microorganisms adhering to the contact lens afterwards but also to prevent the microorganisms from adhering to the contact lens and the lens case in advance.

  Thus, as a technique for preventing microorganisms from adhering to the contact lens in advance, there is a method of binding and adsorbing a preservative such as benzalkonium chloride to the contact lens material (Patent Document 1). However, in such a method, since a toxic preservative always comes into contact with the corneal surface, there is a risk of affecting the ocular surface, which is unacceptable in terms of safety. Further, it is disclosed that a contact lens is immersed in a composition containing a polyoxyethylene polyoxypropylene block copolymer, thereby exhibiting an adhesion suppressing effect on microorganisms after the immersion (Non-patent Documents 2 and 3). However, the concentration of poloxamer that exhibits the effect of suppressing the adhesion of microorganisms is set to 0.5 to 15%. At this concentration, not only safety is a concern, but also such a concentrated poloxamer solution has an extremely high viscosity. There is a concern that the user may feel uncomfortable when wearing the lens with the sticking.

  In conventional contact lens care methods or contact lens care compositions, a sufficient effect of suppressing microbial adhesion has not been obtained.

“Biofilm Formation in Contact Lenses”, Nihon Kore, 39: 143-147, 1997 Journal of Biomedical Materials Reserach, Vol.28,303-309,1994 Antimicrobial Agents and Chemotherapy, Vol.44 No.4,1093-1096,2000

JP-A-5-269181

  The objective of this invention is providing the contact lens care method used for the contact lens care method which suppresses microorganisms adhesion to a contact lens or a contact lens case, and such a method.

  The present inventors have made various studies in order to solve the above-mentioned problems. As a result, the contact lenses are immersed in a composition for contact lens care containing a polyoxyethylene sorbitan fatty acid ester and a buffer for a predetermined time or more. As a result, the inventors have found a completely new finding that the adhesion of microorganisms to the contact lens can be suppressed, thereby completing the present invention.

That is, the gist of the present invention is as follows.
[1] To a contact lens or contact lens case, wherein the contact lens is immersed in a contact lens care composition containing A) polyoxyethylene sorbitan fatty acid ester and B) a buffering agent for 1 hour or more. Microbial adhesion control method,
[2] A contact lens is immersed in a composition for contact lens care containing A) polyoxyethylene sorbitan fatty acid ester, B) buffer, and C) nonionic surfactant, for 1 hour or more. A method for suppressing microbial adhesion to a contact lens or contact lens case
[3] A contact lens is immersed in a contact lens care composition containing a monoterpene in the contact lens care composition used in the method according to [1] or [2]. A method for suppressing microbial adhesion to a contact lens or contact lens case,
[4] The contact lens is immersed in the contact lens care composition further containing an antibacterial agent in the contact lens care composition used in the method according to any one of [1] to [2] for 1 hour or more. A method for suppressing microbial adhesion to a contact lens or a contact lens case,
[3] The present invention relates to a contact lens care composition used in the method according to [1] to [4].

  INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a contact lens care method and a care composition exhibiting an effect of suppressing microbial adhesion.

  According to the contact lens care method of the present invention, microorganisms can be prevented from adhering to, invading, or proliferating into the contact lens or the contact lens case during contact lens wearing or storage, Problems can be prevented beforehand.

  For example, it is possible to keep the contact lens being worn clean, reduce the feeling of foreign matter, and reduce the fogging of the lens. Further, the contact lens material can be prevented from being corroded and deteriorated, and the lens life can be extended. In addition, microorganisms once depleted after contact lenses are soaked in contact lens disinfecting or cleaning compositions for a long period of time will grow again, or water in lavatory or bathrooms where microbial activity is active. Even when the inside and outside of the contact lens case are exposed to microbial contamination due to storage and handling around them, there is an effect of keeping the contact lens immersed in the case clean. Eventually, it can be expected to prevent eye infections such as sty, conjunctiva and cornea, complications such as giant papillary conjunctivitis, corneal epithelial disorder, and visual acuity, which can be caused by microorganisms attached to contact lenses.

  The method for suppressing microbial adhesion to a contact lens of the present invention is characterized in that the contact lens is immersed in a composition for contact lens care containing A) a polyoxyethylene sorbitan fatty acid ester and B) a buffer for a predetermined time or more. And Another method for inhibiting microbial adhesion to a contact lens of the present invention is a contact lens care composition containing A) a polyoxyethylene sorbitan fatty acid ester, B) a buffer, and C) a nonionic surfactant. In addition, the contact lens is immersed for a predetermined time or longer. Microorganisms can be prevented from adhering to the contact lens immersed in the contact lens care composition and the contact lens case containing the contact lens care composition.

  The method of the present invention can be applied to any contact lenses such as hard contact lenses, oxygen permeable hard contact lenses, soft contact lenses (containing or not containing water), plastic resins used for storing contact lenses that are not worn. Can be used for lens cases. Among them, the soft contact lens can be suitably used as a care method for the soft contact lens because it has a high moisture content and adheres to microorganisms, and easily penetrates into the lens and proliferates.

  By using the method of the present invention, microorganism adhesion to the contact lens can be suppressed. Examples of such microorganisms include bacteria, fungi, viruses, chlamydia, parasites (acanthamoeba, etc.), and the main types include the genus Pseudomonas (P. aeruginosa, P. stutzeri, P. cepacia, etc.), Staphylococcus Genus (S. epidermidis, S. aureus, etc.), E. coli group including Echerichia (E. coli, Enterobacter, etc.), Serratia (S. marcescens, etc.), Streptococcus (S. pneumoniae, etc.), Chlamydia ( C. trachomatis etc.), Corynebacterium genus, Candida genus (C. albicans etc.), Aspergillus genus (A. niger etc.), Cladosporium genus, Fusarium genus, virus (Herpes simplex etc.), Acanthamoeba genus (A. castellanii, A. polyphaga) Etc.).

  When immersed in the specific contact lens care composition of the present invention for a predetermined time or longer according to the method of the present invention, adhesion of microorganisms to the contact lens or the contact lens case is suppressed. For example, after the test substance (contact lens, contact lens case, etc.) is immersed in a chemical solution for a certain period of time, the test substance is further immersed in a microorganism suspension for a certain period of time. After rinsing lightly, it can be confirmed by testing whether the number of microorganisms remaining in the test substance is statistically less than the number of microorganisms when not immersed in the chemical solution.

  In the method of the present invention, an appropriate amount of a contact lens care composition containing A) polyoxyethylene sorbitan fatty acid ester and B) a buffer is placed in a container such as a contact lens case and the like. Immerse the contact lens. In order to exert the effect of suppressing the adhesion of microorganisms, it is necessary to immerse the contact lens in the composition for a predetermined time or more. The immersion time is preferably 1 hour or longer, more preferably 4 hours or longer, and particularly preferably 8 hours or longer.

  Further, in the method of the present invention, in addition to the above-mentioned essential components, C) a contact lens care composition containing a nonionic surfactant is used to suppress adhesion of microorganisms to the contact lens or the contact lens case. be able to. Furthermore, the contact lens care composition used in the present invention can realize a contact lens care method having a higher effect of suppressing the adhesion of microorganisms by containing a monoterpene or / and an antibacterial agent.

  The composition for contact lens care used in the method for inhibiting microbial adhesion of the present invention contains polyoxyethylene sorbitan fatty acid ester as an essential component. Examples of the polyoxyethylene sorbitan fatty acid ester used in the present invention include mono coconut oil fatty acid polyoxyethylene sorbitan, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monoisostearate, polyoleic monooleate Oxyethylene sorbitan, polyoxyethylene sorbitan trioleate, and the like can be used, and commercially available ones can be used. Particularly preferred is polyoxyethylene sorbitan monooleate, and the number of added moles of polyoxyethylene is preferably 20. A polyoxyethylene sorbitan fatty acid ester having an HLB of 9 or more is preferred, and a polyoxyethylene sorbitan fatty acid ester having an HLB of 14 or more is more preferred.

  The concentration of the polyoxyethylene sorbitan fatty acid ester in the contact lens care composition used in the method of the present invention is preferably 0.0002% by weight or more from the viewpoint of the effect of inhibiting the adhesion of microorganisms. From the viewpoint, it is preferably 2% by weight or less. The concentration is preferably 0.002 to 0.5% by weight, more preferably 0.004 to 0.2% by weight, and most preferably 0.008 to 0.1% by weight.

  The contact lens care composition used in the method of the present invention contains a buffer as an essential component. Examples of the buffer include borate buffer, phosphate buffer, carbonate buffer, citrate buffer, acetate buffer, tris (hydroxymethyl) aminomethane buffer, and buffers such as HEPES. Preferred are borate buffer, phosphate buffer, and citrate buffer. More specifically, borates such as alkali metal borate and alkaline earth metal borate can be used alone or in combination as the borate buffer. As the phosphate buffer, phosphates such as alkali metal phosphates and alkaline earth metal phosphates can be used alone or in combination. In addition, you may use these buffering agents in combination of 1 or more types.

  The concentration of the buffering agent in the composition for contact lens care used in the method of the present invention is preferably 0.001% by weight or more from the viewpoint of the effect of suppressing microbial adhesion, and from the viewpoint of suppressing eye irritation caused by excessive concentration. % By weight or less is preferred. The concentration is preferably 0.001 to 10% by weight, more preferably 0.01 to 1% by weight, and most preferably 0.02 to 2% by weight.

  Further, in the contact lens care composition used in the method of the present invention, A) a polyoxyethylene sorbitan fatty acid ester, and B) a contact lens care composition containing a buffer, in addition to the polyoxyethylene sorbitan fatty acid ester. By containing at least one nonionic surfactant, it is possible to enhance the effect of inhibiting the adhesion of microorganisms.

  The nonionic surfactant is not particularly limited as long as it is a nonionic surfactant that can be applied to contact lenses. For example, POE / POP block copolymer-substituted ethylenediamine, POE / POP block copolymer, POE (60) POE hydrogenated castor oil such as hydrogenated castor oil, POE alkyl ethers such as POE (9) lauryl ether, POE / POP alkyl ethers such as POE (20) POP (4) cetyl ether, POE (10) nonylphenyl ether, etc. Nonionic surfactants such as POE alkylphenyl ethers. POE is an abbreviation for polyoxyethylene and POP is an abbreviation for polyoxypropylene, and the numbers in parentheses indicate the number of moles added.

  Among these nonionic surfactants, POE / POP block copolymer and POE / POP block copolymer substituted ethylenediamine are particularly preferable. POE / POP block copolymers include (registered trademark) poloxamer ((registered trademark) Pluronic F127, P123, F98, F87, F85, F77, F83, P85, F88, F68, F38, L44), (registered trademark) poloxamine ( (Registered Trademarks) Tetronic 1508, 1504, 1307, 1304, 1107, 1104, 908, 904, 707, 704, 501, 304, etc.) and the like can be used. The average molecular weight is preferably 2,000 to 20,000, and more preferably 5,000 to 15,000. Further, the ethylene oxide content in the total molecule is preferably 40% or more, and more preferably 70% or more.

  The concentration of the nonionic surfactant in the composition for contact lens care used in the method of the present invention is preferably 0.001% by weight or more from the viewpoint of the effect of suppressing the adhesion of microorganisms, From the viewpoint of suppressing unpleasant stickiness, it is preferably 10% by weight or less. The concentration is preferably 0.001 to 10% by weight, more preferably 0.01 to 1% by weight, and most preferably 0.02 to 0.5% by weight.

  The contact lens care composition used in the method of the present invention preferably contains an inorganic salt from the viewpoint of the effect of suppressing the adhesion of microorganisms. Examples of inorganic salts include sodium chloride and potassium chloride. The concentration of the inorganic salts in the composition of the present invention is preferably 0.2 to 2.0% by weight, more preferably 0.1 to 1.0% by weight. The concentration is particularly preferably 0.2% by weight or more from the viewpoint of maintaining the shape of the water-containing contact lens, and preferably 2.0% by weight or less from the viewpoint of the effect of suppressing the adhesion of microorganisms.

  In the contact lens care composition used in the method of the present invention, the effect of attaching microorganisms can be enhanced by further using a monoterpene. Examples of such monoterpenes include menthol, camphor, borneol, geraniol, cineol, anethole, limonene, eugenol and the like. These monoterpenes may be any of d-form, l-form or dl-form, among which 1-menthol, d-menthol, dl-menthol, d-camphor, dl-camphor, d-borneol and dl-borneol Is preferred. Geraniol, l-menthol, d-camphor and d-borneol are particularly preferred from the viewpoints of sensory aspects such as refreshing feeling and fragrance, and safety. These can also be used in the state contained in essential oil, Preferably, eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, etc. can also be used. These monoterpenes can be used alone or in combination of two or more. In addition to the monoterpenes, sesquiterpenes such as farnesol and nerolidol, diterpenes such as sitol and semblene, and the like can be appropriately used as desired. These terpenoids may be d-form, l-form or dl-form.

  The concentration of the monoterpene in the contact lens care composition used in the method of the present invention is preferably 0.00001 to 0.1% by weight, more preferably 0.0001 to 0.05% by weight, and most preferably 0.0001 to 0.01% by weight. The amount is preferably 0.1% by weight or less, and preferably 0.00001% by weight or more from the viewpoint of obtaining a sufficient microbial adhesion suppressing effect.

  Further, the contact lens care composition used in the method of the present invention preferably contains an antibacterial agent. The number of microorganisms adhering to the contact lens can be sterilized while the contact lens is immersed, and the number of the microorganisms can be reduced. it can.

  The antibacterial agent is not limited as long as it is a highly safe antibacterial agent used in a contact lens care composition. For example, polydronium chloride (polyquarterium-1), poly [oxyethylene (dimethyliminio) Quaternary ammonium compounds such as ethylene- (dimethyliminio) ethylene dichloride] or salts thereof, biguanide compounds such as polyhexamethylene biguanide hydrochloride or salts thereof, and glycine type surfactants such as alkylpolyaminoethylglycine. .

  As these antibacterial agents, commercially available products can be used. For example, quaternary ammonium compounds or salts thereof include Glokill PQ (trade name, manufactured by Rhodia), Unisense CP (trade name, poly (diallyldimethylammonium chloride), Senka Co., Ltd.), WSCP (trade name, poly [oxyethylene (dimethyliminio) ethylene- (dimethyliminio) ethylene dichloride] containing about 60% by weight, manufactured by Bachman Laboratories), Croquat L (trade name, Lauryl) A quaternary ammonium-substituted polypeptide derived from a collagen hydrolyzate having a trimethylammonium chloride group, which is available from Clauder). The biguanide compound or a salt thereof can be obtained from Cosmosil CQ (trade name, containing about 20% by weight of polyhexamethylene biguanide hydrochloride, manufactured by ICI Americas).

  The concentration of the antibacterial agent in the contact lens care composition used in the present invention is preferably 0.00001 to 0.5% by weight, particularly preferably 0.00001 to 0.01% by weight. The concentration is preferably 0.00001% by weight or more from the viewpoint of obtaining sufficient sterilizing power, and preferably 0.5% by weight or less from the viewpoint of safety.

  The contact lens care composition used in the present invention includes, as necessary, a pharmaceutically active ingredient, a surfactant other than the above, an isotonic agent, a thickener, a chelating agent, a stabilizer, a pH adjuster, antiseptic, and the like. Various additives such as a preservative, a preservative, a refreshing agent, and a suspending agent can be appropriately mixed within a concentration range that does not affect the physicochemical parameters of the contact lens and causes no problems such as eye irritation. Although a specific example is given below, it is not limited to these.

  As the pharmaceutically active ingredient, an ingredient used as an active ingredient of an ophthalmic composition can be used. For example, a decongestant, a muscle regulating agent, an anti-inflammatory / astringent, an antihistamine, a vitamin, a sulfa, an antiallergy Agents, cell activators, and the like. Specifically, epinephrine, epinephrine hydrochloride, ephedrine hydrochloride, tetrahydrozoline hydrochloride, oxymetazoline hydrochloride, naphazoline hydrochloride, nafazoline nitrate, phenylephrine hydrochloride, dl-methylephedrine hydrochloride, etc. Removal components, muscle regulating functional agents such as neostigmine methylsulfate, epsilon-aminocaproic acid, allantoin, berberine chloride, berberine sulfate, sodium azulenesulfonate, dipotassium glycyrrhizinate, zinc sulfate, zinc lactate, lysozyme, etc. ,salt Antihistamines such as diphenhydramine and chlorpheniramine maleate, sodium flavin adenine dinucleotide, cyanocobalamin, retinol acetate, retinol palmitate, pyridoxine hydrochloride, panthenol, calcium pantothenate, sodium pantothenate, tocopherol acetate, riboflavin, Sulfa drugs such as famethoxazole, sulfamethoxazole sodium, sulfisoxazole, sulfisomidine sodium, antiallergic agents such as cromoglycate sodium, ketotifen fumarate, amlexanox, pemirolast potassium, tranilast, L -Potassium aspartate, magnesium L-aspartate, magnesium-potassium L-aspartate, aminoethylsulfonic acid, kon Cell activator such Roichin sodium sulfate including but not limited to.

  Surfactants include amphoteric surfactants such as glycine type such as alkyldiaminoethylglycine, betaine acetate type such as lauryldimethylaminoacetic acid betaine, imidazoline type, and POE alkyl ether phosphorus such as POE (10) sodium lauryl ether phosphate. Acids and salts thereof, N-acyl amino acid salts such as sodium lauroylmethylalanine, alkyl ether carboxylates, N-acyl taurine salts such as N-cocoylmethyl taurine sodium, sulfonates such as sodium tetradecenesulfonate, lauryl sulfate Examples thereof include alkyl sulfates such as sodium, POE alkyl ether sulfates such as POE (3) sodium lauryl ether sulfate, and anionic surfactants such as α-olefin sulfonates. POE is an abbreviation for polyoxyethylene and POP is an abbreviation for polyoxypropylene.

  Examples of isotonic agents include glycerin, propylene glycol, glucose, mannitol, sorbitol and the like.

  Thickeners include gum arabic powder, sodium alginate, propylene glycol alginate, sodium chondroitin sulfate, sorbitol, dextran 70, tragacanth powder, methylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, carboxyvinyl polymer, polyvinyl alcohol, polyvinyl Examples include pyrrolidone and macrogol 4000.

  Chelating agents include edetic acid, edetates (disodium edetate, disodium calcium edetate, trisodium edetate, tetrasodium edetate), nitrilotriacetic acid and its salts, trihydroxymethylaminomethane, sodium hexametaphosphate Citric acid and the like.

  Examples of the stabilizer include the edetic acid, the edetic acid salts, and sodium bisulfite.

  Examples of the pH adjuster include sodium hydroxide, potassium hydroxide, hydrochloric acid, sulfuric acid, acetic acid and the like.

  Preservatives and preservatives include sorbic acid, potassium sorbate, sodium sorbate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, chlorohexidine gluconate, chlorohexidine hydrochloride, benzalkonium chloride, benzethonium chloride, alkyl Examples include diaminoethylglycine and chlorobutanol.

  The contact lens care composition used in the method of the present invention can be produced according to a known method.

  The pH of the contact lens care composition used in the method of the present invention is not particularly limited, but is preferably about 5.0 to 9.0, more preferably 5 in view of safety for eyes. It is desirable to adjust in the range of .5 to 8.5. Adjustment of pH is performed by using the said pH adjuster. Further, the osmotic pressure ratio of the composition to the physiological saline (the osmotic pressure of the ophthalmic composition / the osmotic pressure of the physiological saline) is preferably 0.5 to 2.5, more preferably 0.7 to 1.5. It is desirable to adjust. Moreover, it is preferable that the osmotic pressure of a composition is about 140-700 mOsm, More preferably, it is 200-420 mOsm. The osmotic pressure can be measured with an osmometer.

Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited thereto.
Test Example 1 Microorganism Adhesion Inhibition Effect Evaluation Test Pseudomonas aerginosa ATCC9027 was used as a test bacterium, and 2 week Accuview (manufactured by Johnson & Johnson Co., Ltd.) was used as a test lens. Based on the formulation described in Table 1, the test solutions were prepared so that polysorbate 80, Pluronic (registered trademark) F127, and the like each had a concentration (w / v)% described in the table.

The test method was as follows (the test was performed with n = 5).
(1) The lens was immersed in 5 mL of each test solution in a 12-well multiplate for 4 hours.
(2) The lens was taken out from the test solution using sterilized tweezers, and water droplets were gently wiped off, and then immersed in 5 mL of a test bacterial solution adjusted to 1 × 10 ⁷ CFU / mL for 30 minutes.
(3) After immersion, remove the lens from the test bacterial solution and gently wipe off the water droplets, then transfer to a 5 mL commercial Dulbecco's salt buffer solution (pH 7.5, osmotic pressure 300 mOsm) in a Spitz tube, and manually Gently soaked for 1 minute.
(4) The lens was taken out from the buffer solution in (3) and lightly wiped with water droplets. The lens was transferred to a new Dulbecco's phosphate buffer solution, treated with ultrasound for 3 minutes, and then vigorously stirred with vortex for 1 minute.
(5) The number of viable bacteria in the buffer solution of (4) above was appropriately diluted and measured by the membrane filter method to obtain the number of adherent bacteria.

  About the test liquid prepared so that it might become the composition of Table 1, the microbe adhesion inhibitory effect was evaluated. The adhesion inhibition rate (%) was the ratio obtained by dividing the number of adherent bacteria in the test solution (comparative example or example) by the number of adherent bacteria in the control test solution. The results are shown in Table 1.

  As a result of the test, polyoxyethylene sorbitan fatty acid ester (polysorbate 80: polyoxyethylene (20) sorbitan monooleate, the number in parentheses indicates the number of added moles), sodium hydrogen phosphate and sodium dihydrogen phosphate were combined. It was shown that Pseudomonas aeruginosa adheres to the contact lens can be remarkably suppressed by immersing the contact lens in the composition for 4 hours. In addition, when immersed in a composition combining polyoxyethylene sorbitan fatty acid ester, sodium hydrogen phosphate, sodium dihydrogen phosphate, and further combining a polyoxyethylene polyoxypropylene block copolymer (Pluronic F127) It was confirmed that the effect of suppressing the adhesion of microorganisms was further increased.

On the other hand, even when the contact lens was immersed in a composition comprising a combination of a polyoxyethylene polyoxypropylene block copolymer, sodium hydrogen phosphate, and sodium dihydrogen phosphate for 4 hours, the effect of inhibiting microbial adhesion was not sufficiently obtained.
Test Example 2 Microorganism Adhesion Inhibition Effect Evaluation Test The test solution (pH 7.5) prepared to have the composition described in Table 2 shows the results of evaluating the fungus adhesion inhibition effect in the same manner as in Test Example 1. The case where the adhesion inhibition rate (%) was 80% or more was evaluated as ◎, the case where it was 60% or more and less than 80% was evaluated as ○, and the case where it was less than 60% was evaluated as ×.

  As a result of the test, the contact lens was immersed for 4 hours in a composition comprising a combination of polyoxyethylene sorbitan fatty acid ester (polysorbate 80), a buffer, a nonionic surfactant, 1-menthol and an antibacterial agent. It was shown that the adhesion of Pseudomonas aeruginosa can be remarkably suppressed.

Claims (3)

Microbial adhesion to a contact lens or contact lens case, wherein the contact lens is immersed in a composition for contact lens care containing A) polyoxyethylene sorbitan fatty acid ester and B) a buffering agent for 1 hour or more Suppression method. The contact lens is immersed in a composition for contact lens care containing A) polyoxyethylene sorbitan fatty acid ester, B) buffer, and C) nonionic surfactant for 1 hour or more, and the contact A method for suppressing microbial adhesion to a lens or a contact lens case. The composition for contact lens care used for the method of Claim 1 or 2.