JP2011201581A - Low adhesive packing material - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a low adhesive packing material used as an external packing material, where only one sheet of transdermal medicine which penetrates active substance(s) through skin, is accommodated therein, while taking an easiness of extraction of the content from the package in consideration.SOLUTION: Front and back side films are welded on the outer periphery to form a bag shape, and the innermost layer of each film is formed of a co-extrusion laminated film including a polyolefin layer, adhesive resin layer, and polyethylene terephthalate resin layer, in this order from the front side. A peel starting portion, which is formed adjacent to the welded portion where the polyethylene terephthalate resin layer surfaces are welded, is provided so that the peel starting portion serving as a cue to open the package by utilizing interlayer peeling of the innermost layers.

Description

  The present invention relates to a low adsorptive packaging material that seals a single percutaneous absorbent such as a patch or a patch.

  2. Description of the Related Art In food and pharmaceutical packaging materials, a phenomenon in which an active ingredient and a trace amount component having a high cost are adsorbed or sorbed on a heat-welded layer has been a problem. For this reason, the amount of the adsorbed and sorbed amount is anticipated so that the content component is excessively contained, and the effect and efficacy are stably expressed even after the adsorbed and sorbed. In recent years, as described in Patent Document 1, polyethylene terephthalate resin (non-crystalline PET), polyacrylonitrile resin (PAN), and the like have been used. It is used in pharmaceutical packaging materials.

However, contents that require non-adsorbability such as PAN and non-crystalline PET cannot be attached with a chuck for resealing. Was mostly small.
For this reason, in view of ease of taking out, what is torn from two directions as described in Patent Document 2 is widely used.

JP-A-8-143453 JP 2008-213923 A

  The present invention has been made to solve the problems of the prior art, and it has been a problem to provide a low-adsorbent packaging material in consideration of the ease of taking out the contents.

  The present invention has been made to solve the above-mentioned problems, and the invention of claim 1 is a low-adsorbent packaging material that contains only one transdermal absorbent that permeates an active ingredient through the skin. The innermost layer of each film formed into a bag shape by thermally welding the outer periphery of the front and back films is a coextruded laminated film of a polyolefin layer, an adhesive resin layer, and a polyethylene terephthalate resin layer from the surface side, and the polyethylene terephthalate resin A low adsorptive packaging material provided with a peeling start portion that is formed adjacent to a heat-welded portion where the layer surfaces are heat-welded and opens when utilizing delamination of the innermost layer.

  The invention according to claim 2 is characterized in that the thickness of the innermost co-extruded laminated film is 50 μm or less and the thickness of the polyethylene terephthalate resin layer is 5 μm or less. It is a material.

  The invention of claim 3 is characterized in that the seal strength after heat welding of the heat welded portion is 15 N / 15 mm or less, and the peeling start portion is made smaller than the heat welded portion. This is a low adsorptive packaging material.

  A low-adsorptive polyethylene terephthalate-based resin layer with low seal strength after heat welding is provided in the innermost layer, so that the contents can be easily taken out even if the bag is small, without compromising the low adsorbability of the content components. Can be obtained.

  A packaging bag in which the thickness of the coextruded laminated film of the innermost layer is 50 μm or less and the thickness of the polyethylene terephthalate resin layer is 5 μm or less so that the polyethylene terephthalate resin layer can be stably destroyed and delaminated when opened. Can be obtained.

  By devising the shape of the peeling start part by setting the seal strength after heat welding to 15 N / 15 mm or less, it is possible to provide a packaging bag that is easy to take out the contents considering the universal design.

  Furthermore, a compact packaging bag can be obtained by eliminating the cut line as an opening assisting means.

It is an example of sectional drawing of the laminated | multilayer film used for the low adsorptive packaging material of this invention. It is an expanded sectional view of the heat welding layer of the laminated | multilayer film used for the low adsorptive packaging material of this invention. It is the plane schematic of the low adsorptive packaging material of this invention, and is the example of heat welding which showed an example of the non-thermal welding part which is an opening start part.

The example of the form for implementing this invention is demonstrated concretely below.
FIG. 1 is an example of a cross-sectional view of a laminated film used in the low adsorptive packaging material of the present invention.
The base material layer (1) is not particularly limited as long as it is a film that can be used as a printing base material and has a necessary barrier property. ) Any commercially available film may be used as long as it is a stretched film such as a film and a stretched film on which an inorganic compound such as alumina or silica is transparently deposited.
There are no particular restrictions on the thickness of the various films used for the substrate layer (1). For PET films, 30 μm or less, for OPP films, about 20 μm to 40 μm, for ONy films, about 10 μm to 30 μm are suitable. is there.
Adhesive layer (2) is 1 solution used in dry lamination, or any if two-component curing type urethane-based adhesive may be used, the coating amount on drying is ^1g / m ² ~3g / m 2 about It is desirable from the viewpoint of adhesive strength.
There is no problem as long as the heat-welded layer (3) is a coextruded film laminated in the order of the polyolefin layer (4), the adhesive resin layer (5), and the PET resin layer (6), and the thickness is 50 μm or less The thickness of the PET resin layer is desirably 5 μm or less. FIG. 2 is an enlarged cross-sectional view of the heat welding layer (3) of FIG.
FIG. 3 is a schematic plan view of the low adsorptive packaging material of the present invention, and is an example of heat welding in consideration of an easily peelable portion.
Here, the heat welding part (8) is a region inside the outline of the substrate and is formed at a position larger than the contents, and a non-thermal welding part (9) is provided in contact with the end part. At the time of opening, the non-thermally welded part (9) can be used as a trigger to easily peel off and open the surrounding heat welded part (8). The position and shape of the non-thermally welded portion are not limited to the illustrated example, and may be arranged so that the opening operation can be easily performed.

<Example 1>
A laminated film in which the base material layer / adhesive layer / thermal welding layer was formed of the following layers was produced.
Base material layer: inorganic compound vapor-deposited film (Toppan Printing Co., Ltd., GL-ARH-F) 12 μm
Adhesive layer: Urethane adhesive (Mitsui Chemicals Polyurethanes Co., Ltd., A-525 / A-52) coating amount (dry) 3 g / m ²
Thermal welding layer: DIC Corporation, TX2457, 30 μm (PET resin layer thickness 5 μm)
<Example 2>
A laminated film was produced in the same manner as in Example 1 except that the heat-welded layer was replaced by Tamapoly Co., Ltd. Hytron PG 30 μm (PET resin layer thickness 5 μm).
<Comparative Example 1>
A laminated film was produced in the same manner as in Example 1 except that the heat welding layer was replaced with 30 μm of LLDPE (SE620M) manufactured by Tamapoly Co., Ltd.

<Experiment 1>
Adsorption amount:
A 100 mm × 100 mm four-sided bag was prepared using the laminated films prepared in the above Examples and Comparative Examples, and 0.3 g of an L-menthol 25 wt% aqueous solution was included in absorbent cotton and sealed. It was left for 1 month in an environment of 40 ° C. and 75% RH. L-menthol was extracted with 50 ml of ethanol, and after extraction, it was calibrated by gas chromatography to determine the adsorption amount. The results are shown in Table 1.

表１に示したとおり、実施例１の積層フィルムを用いた場合には、Ｌ−メントールの吸着量も少なく剥離強度も小さくなっている。実施例２の積層フィルムを用いた場合は吸着量はより少なく剥離強度もやや小さい。比較例１の積層フィルムを用いた場合には吸着量も剥離強度もともに著しく大きかった。 <Experiment 2>
Seal strength:
Using the laminated films prepared in the above examples and comparative examples, heat sealing was performed under the following conditions, and the films were cut into strips having a width of 15 mm, and then peel strength was measured with a tensile tester. The results are shown in Table 1.
Sealing temperature: 160 ° C., sealing time: 1 second, sealing pressure: 2 kgf / cm ² , upper plate one side heating.

As shown in Table 1, when the laminated film of Example 1 was used, the amount of L-menthol adsorbed was small and the peel strength was small. When the laminated film of Example 2 is used, the amount of adsorption is smaller and the peel strength is slightly smaller. When the laminated film of Comparative Example 1 was used, both the adsorption amount and the peel strength were remarkably large.

  The low adsorptive packaging material of the present invention can be used for an outer packaging bag such as a transdermal absorbent.

DESCRIPTION OF SYMBOLS 1 ... Base material layer 2 ... Adhesive layer 3 ... Thermal welding layer 4 ... Polyolefin layer 5 ... Adhesive resin layer 6 ... Polyethylene terephthalate resin layer 7 ... Contents (tape agent)
8 ... Thermal welding part 9 ... Peeling start part (non-thermal welding part)

Claims (3)

  A low-adsorbent packaging material that contains only one transdermal absorbent that allows the active ingredient to permeate through the skin, and the innermost layer of each film that is formed into a bag shape by thermally welding the outer periphery of the front and back films From the coextruded laminated film of polyolefin layer, adhesive resin layer, and polyethylene terephthalate resin layer, using the innermost layer delamination formed adjacent to the heat welded part where the polyethylene terephthalate resin layer surface is heat welded A low adsorptive packaging material provided with a peeling start portion that triggers opening.   2. The low-adsorbent packaging material according to claim 1, wherein the innermost co-extruded laminated film has a thickness of 50 [mu] m or less, and the polyethylene terephthalate resin layer has a thickness of 5 [mu] m or less.   The low adsorptive packaging material according to claim 1 or 2, wherein a seal strength of the heat welded portion after heat welding is 15 N / 15 mm or less, and a peeling start portion is made smaller than the heat welded portion.

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