JP2011195582A - Antibacterial, bactericidal or antiviral composition - Google Patents
Antibacterial, bactericidal or antiviral composition Download PDFInfo
- Publication number
- JP2011195582A JP2011195582A JP2011039290A JP2011039290A JP2011195582A JP 2011195582 A JP2011195582 A JP 2011195582A JP 2011039290 A JP2011039290 A JP 2011039290A JP 2011039290 A JP2011039290 A JP 2011039290A JP 2011195582 A JP2011195582 A JP 2011195582A
- Authority
- JP
- Japan
- Prior art keywords
- antibacterial
- bactericidal
- silver
- antiviral composition
- hydrogen peroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
本発明は、抗菌、殺菌若しくは抗ウイルス性組成物に関する。より詳細に、本発明は、安定化された銀−アミノ酸錯体を含む抗菌、殺菌若しくは抗ウイルス性組成物に関する。 The present invention relates to antibacterial, bactericidal or antiviral compositions. More particularly, the invention relates to antibacterial, bactericidal or antiviral compositions comprising stabilized silver-amino acid complexes.
殺菌剤もしくは抗菌剤として、銀−アミノ酸錯体が知られている。銀−アミノ酸錯体は、非毒性であるので、様々な工業製品や生活用品に使用されている。例えば、銀−アミノ酸錯体を水に添加して、水槽、プール、風呂などに発生しうる菌類等を殺菌できる。樹脂、塗料、接着剤、インクなどに銀−アミノ酸錯体を添加することによって抗菌性や殺菌性を付与できる。各種繊維、紙、皮革、セラミックス、ガラスなどに銀−アミノ酸錯体を塗布あるいは含浸させることによって抗菌性や殺菌性を付与できる。 Silver-amino acid complexes are known as bactericides or antibacterial agents. Since silver-amino acid complexes are non-toxic, they are used in various industrial products and daily necessities. For example, a silver-amino acid complex can be added to water to sterilize fungi that can be generated in water tanks, pools, baths, and the like. Antibacterial and bactericidal properties can be imparted by adding silver-amino acid complexes to resins, paints, adhesives, inks and the like. Antibacterial and bactericidal properties can be imparted by applying or impregnating a silver-amino acid complex to various fibers, paper, leather, ceramics, glass and the like.
銀−アミノ酸錯体として、例えば、特許文献１には、銀−ヒスチジン水溶性錯体が開示されている。また、特許文献２には、銀等の金属塩化合物とグルタミン酸、ロイシン、アルギニンなどのアミノ酸とを混合して、約２．０以下のｐＨで銀−アミノ酸錯体を調製したことが開示されている。そして、銀−アミノ酸錯体に過酸化水素水または水を添加した実施例が示されている。特許文献３には、ヒスチジン銀錯体とヒドロキシカルボン酸、多価カルボン酸およびそれらの塩からなる群から選ばれる少なくとも１種とを含有する液状組成物が開示されている。
これら銀−アミノ酸錯体は、紫外線照射の影響によって銀イオンが還元等して変色することがある。また、塩化物イオンなどによって、銀イオンを含む化合物が析出したり、沈殿したりすることがある。
As a silver-amino acid complex, for example, Patent Document 1 discloses a silver-histidine water-soluble complex. Patent Document 2 discloses that a silver-amino acid complex was prepared at a pH of about 2.0 or less by mixing a metal salt compound such as silver and an amino acid such as glutamic acid, leucine, and arginine. . And the Example which added hydrogen peroxide water or water to the silver-amino acid complex is shown. Patent Document 3 discloses a liquid composition containing a histidine silver complex and at least one selected from the group consisting of hydroxycarboxylic acids, polyvalent carboxylic acids and salts thereof.
These silver-amino acid complexes may be discolored due to reduction of silver ions or the like due to the influence of ultraviolet irradiation. In addition, a compound containing silver ions may be precipitated or precipitated by chloride ions or the like.
非特許文献１には、銀−アミノ酸錯体のｐＨを高くすると、塩化物イオンに対する安定性が増加したとの報告がされている。 Non-Patent Document 1 reports that when the pH of the silver-amino acid complex is increased, the stability against chloride ions is increased.
本発明者らは、非特許文献１に従って、銀−アミノ酸錯体を含有する水溶液のｐＨを高くしてみたところ、塩化物イオンに対する安定性が増加した。しかしながら、紫外線に対する安定性は解決されておらず、変色を防止することができなかった。また、銀−アミノ酸錯体の安定性を向上させることができても殺菌性等の活性が低下してしまうことがあった。
そこで、本発明は、紫外線に対しての安定性が高い銀−アミノ酸錯体を含有する抗菌、殺菌若しくは抗ウイルス性組成物を提供することが、課題である。
In accordance with Non-Patent Document 1, the present inventors tried increasing the pH of an aqueous solution containing a silver-amino acid complex, and the stability against chloride ions increased. However, the stability against ultraviolet rays has not been solved, and discoloration could not be prevented. Moreover, even if the stability of the silver-amino acid complex can be improved, the activity such as bactericidal properties may be lowered.
Therefore, an object of the present invention is to provide an antibacterial, bactericidal or antiviral composition containing a silver-amino acid complex having high stability against ultraviolet rays.
本発明者らは、上記課題を解決すべく鋭意検討した結果、特定のモル比で構成される銀−アミノ酸錯体に、過酸化水素を混合させ、且つ高ｐＨに調整した組成物は、紫外線が照射されても若しくは塩化物イオンが存在しても、着色や白濁などが生じないことを見出した。本発明は、この知見に基づいてさらに検討を加えることによって、完成するに至ったものである。 As a result of intensive studies to solve the above problems, the present inventors have found that a composition prepared by mixing hydrogen peroxide with a silver-amino acid complex having a specific molar ratio and adjusting to a high pH has ultraviolet rays. It was found that coloring or white turbidity did not occur even when irradiated or in the presence of chloride ions. The present invention has been completed by further studies based on this finding.
すなわち本発明は、以下のものを含む。
〔１〕 銀１モル部およびアミノ酸１〜３モル部からなる銀−アミノ酸錯体と、 過酸化水素または過酸化水素を発生させる化合物とを、 銀１モルに対して過酸化水素が０．００２〜１０００モルとなる割合で含有し、且つｐＨが６以上である、抗菌、殺菌若しくは抗ウイルス性組成物。
〔２〕 アミノ酸がヒスチジンである、上記〔１〕に記載の抗菌、殺菌若しくは抗ウイルス性組成物。
〔３〕 過酸化水素または過酸化水素を発生させる化合物が過酸化ナトリウムである、上記〔１〕または〔２〕に記載の抗菌、殺菌若しくは抗ウイルス性組成物。
〔４〕 ヒドロキシカルボン酸、多価カルボン酸およびそれらの塩からなる群から選択される１種以上をさらに含有する、上記〔１〕〜〔３〕のいずれか１項に記載の抗菌、殺菌若しくは抗ウイルス性組成物。
〔５〕 グルクロン酸、クエン酸およびそれらの塩からなる群から選択される１種以上をさらに含有する、上記〔１〕〜〔３〕のいずれか１項に記載の抗菌、殺菌若しくは抗ウイルス性組成物。
That is, the present invention includes the following.
[1] A silver-amino acid complex composed of 1 mol of silver and 1-3 mol of amino acid, and hydrogen peroxide or a compound that generates hydrogen peroxide. An antibacterial, bactericidal or antiviral composition containing 1000 mol and having a pH of 6 or more.
[2] The antibacterial, bactericidal or antiviral composition according to [1] above, wherein the amino acid is histidine.
[3] The antibacterial, bactericidal or antiviral composition according to [1] or [2] above, wherein the hydrogen peroxide or the compound that generates hydrogen peroxide is sodium peroxide.
[4] The antibacterial or bactericidal or sterilizing or any one of the above [1] to [3], further containing one or more selected from the group consisting of hydroxycarboxylic acids, polyvalent carboxylic acids and salts thereof Antiviral composition.
[5] The antibacterial, bactericidal or antiviral property according to any one of the above [1] to [3], further containing one or more selected from the group consisting of glucuronic acid, citric acid and salts thereof Composition.
〔６〕 上記〔１〕〜〔５〕のいずれか１項に記載の抗菌、殺菌若しくは抗ウイルス性組成物を含有する製品。
〔７〕 樹脂と、上記〔１〕〜〔５〕のいずれか１項に記載の抗菌、殺菌若しくは抗ウイルス性組成物とを含有する樹脂組成物。
〔８〕 上記〔１〕〜〔５〕のいずれか１項に記載の抗菌、殺菌若しくは抗ウイルス性組成物を含有する塗料。
〔９〕 上記〔１〕〜〔５〕のいずれか１項に記載の抗菌、殺菌若しくは抗ウイルス性組成物を含有する金属加工油。
〔１０〕 上記〔１〕〜〔５〕のいずれか１項に記載の抗菌、殺菌若しくは抗ウイルス性組成物を含有する接着剤。
〔１１〕 銀１モル部およびアミノ酸１〜３モル部からなる銀−アミノ酸錯体に、 過酸化水素または過酸化水素を発生させる化合物を、 銀１モルに対して過酸化水素が０．００２〜１０００モルとなる割合で混合し、且つ ｐＨを６以上に調整することを含む、抗菌、殺菌若しくは抗ウイルス性組成物の製造方法。
〔１２〕 アミノ酸がヒスチジンである、上記〔１１〕に記載の抗菌、殺菌若しくは抗ウイルス性組成物の製造方法。
〔１３〕 過酸化水素または過酸化水素を発生させる化合物が過酸化ナトリウムである、上記〔１１〕または〔１２〕に記載の抗菌、殺菌若しくは抗ウイルス性組成物の製造方法。
〔１４〕 ヒドロキシカルボン酸、多価カルボン酸およびそれらの塩からなる群から選択される１種類以上をさらに混合する、上記〔１１〕〜〔１３〕のいずれか１項に記載の抗菌、殺菌若しくは抗ウイルス性組成物の製造方法。
〔１５〕 グルクロン酸、クエン酸およびそれらの塩からなる群から選択される１種類以上をさらに混合する、上記〔１１〕〜〔１３〕に記載の抗菌、殺菌若しくは抗ウイルス性組成物の製造方法。
[6] A product containing the antibacterial, bactericidal or antiviral composition according to any one of [1] to [5].
[7] A resin composition comprising a resin and the antibacterial, bactericidal or antiviral composition according to any one of [1] to [5] above.
[8] A paint containing the antibacterial, bactericidal or antiviral composition according to any one of [1] to [5].
[9] A metal processing oil containing the antibacterial, bactericidal or antiviral composition according to any one of [1] to [5].
[10] An adhesive containing the antibacterial, bactericidal or antiviral composition according to any one of [1] to [5].
[11] Hydrogen peroxide or a compound that generates hydrogen peroxide is added to a silver-amino acid complex composed of 1 mol of silver and 1 to 3 mol of amino acid. A method for producing an antibacterial, bactericidal or antiviral composition comprising mixing at a molar ratio and adjusting the pH to 6 or more.
[12] The method for producing an antibacterial, bactericidal or antiviral composition according to [11] above, wherein the amino acid is histidine.
[13] The method for producing an antibacterial, bactericidal or antiviral composition according to [11] or [12] above, wherein the hydrogen peroxide or the compound that generates hydrogen peroxide is sodium peroxide.
[14] The antibacterial or sterilizing or any one of the above [11] to [13], further mixed with one or more selected from the group consisting of hydroxycarboxylic acid, polyvalent carboxylic acid and salts thereof A method for producing an antiviral composition.
[15] The method for producing an antibacterial, bactericidal or antiviral composition according to the above [11] to [13], wherein at least one selected from the group consisting of glucuronic acid, citric acid and salts thereof is further mixed .
本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、紫外線を含む光照射下等でも銀の析出等による変色や白濁を起こさず、保存安定性に優れている。さらに、本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、優れた抗菌、殺菌若しくは抗ウイルス効果を示す。 The antibacterial, bactericidal or antiviral composition of the present invention is excellent in storage stability without causing discoloration or white turbidity due to silver deposition or the like even under irradiation with light including ultraviolet rays. Furthermore, the antibacterial, bactericidal or antiviral composition of the present invention exhibits excellent antibacterial, bactericidal or antiviral effects.
本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、急性経口毒性、皮膚刺激性、粘膜刺激性などの毒性が低い。また、施用対象の素材の品質に影響を及ぼさない。さらに、抗菌性、殺菌性、抗カビ性、抗ウイルス性等の効果が長期間にわたり持続する。 The antibacterial, bactericidal or antiviral composition of the present invention has low toxicity such as acute oral toxicity, skin irritation and mucous membrane irritation. In addition, it does not affect the quality of the material to be applied. Furthermore, effects such as antibacterial properties, bactericidal properties, antifungal properties, and antiviral properties are maintained for a long period of time.
（抗菌、殺菌若しくは抗ウイルス性組成物）
本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、銀−アミノ酸錯体と、過酸化水素または過酸化水素を発生させる化合物とを含有するものである。
(Antimicrobial, bactericidal or antiviral composition)
The antibacterial, bactericidal or antiviral composition of the present invention contains a silver-amino acid complex and hydrogen peroxide or a compound that generates hydrogen peroxide.
本発明に用いられる銀−アミノ酸錯体は、銀１モル部と、アミノ酸１〜３モル部、好ましくは１．５〜２．５モル部とからなる錯体である。この錯体は水溶性であることが好ましい。 The silver-amino acid complex used in the present invention is a complex composed of 1 mol part of silver and 1 to 3 mol part of amino acid, preferably 1.5 to 2.5 mol part. This complex is preferably water-soluble.
銀−アミノ酸錯体は、銀化合物とアミノ酸とを共存させ、銀イオンにアミノ酸を配位させることによって得ることができる。 A silver-amino acid complex can be obtained by coexisting a silver compound and an amino acid and coordinating the amino acid to silver ions.
銀−アミノ酸錯体の調製に用いられる銀化合物は、特に限定されないが、酸化数１の銀化合物が特に好ましい。例えば、硝酸銀、酸化銀、塩化銀などが挙げられる。該銀化合物は１種単独で若しくは２種以上を組み合わせて用いることができる。 Although the silver compound used for preparation of a silver-amino acid complex is not specifically limited, The silver compound of oxidation number 1 is especially preferable. For example, silver nitrate, silver oxide, silver chloride and the like can be mentioned. These silver compounds can be used alone or in combination of two or more.
銀−アミノ酸錯体の調製に用いられるアミノ酸は特に限定されない。例えば、グリシン、アラニン、ロイシン、バリン、グルタミン、グルタミン酸、アスパラギン、アスパラギン酸、ヒスチジン、リジン、アルギニン、システイン、メチオニン、チロシン、トリプトファン等が挙げられる。これらアミノ酸は１種単独で若しくは２種以上を組み合わせて用いることができる。これらのうち塩基性アミノ酸が好ましく、ヒスチジン、リジンおよびアルギニンがより好ましく、ヒスチジンが特に好ましい。 The amino acid used for the preparation of the silver-amino acid complex is not particularly limited. Examples thereof include glycine, alanine, leucine, valine, glutamine, glutamic acid, asparagine, aspartic acid, histidine, lysine, arginine, cysteine, methionine, tyrosine, and tryptophan. These amino acids can be used alone or in combination of two or more. Of these, basic amino acids are preferred, histidine, lysine and arginine are more preferred, and histidine is particularly preferred.
銀−アミノ酸錯体の調製方法は特に制限されない。例えば、硝酸銀などの水溶性銀化合物を水に溶解させ、これにアミノ酸をそのまま若しくは水に溶解させて添加混合することによって、銀−アミノ酸錯体を調製することができる。また、アミノ酸を水に溶解させ、これに酸化銀や塩化銀などの水難溶性銀化合物を添加し、撹拌することによって、銀−アミノ酸錯体を調製することができる。 The method for preparing the silver-amino acid complex is not particularly limited. For example, a silver-amino acid complex can be prepared by dissolving a water-soluble silver compound such as silver nitrate in water and adding and mixing the amino acid as it is or dissolved in water. Moreover, a silver-amino acid complex can be prepared by dissolving an amino acid in water, adding a poorly water-soluble silver compound such as silver oxide or silver chloride thereto, and stirring.
銀−アミノ酸錯体の調製においては、銀化合物中の銀１モルに対してアミノ酸が１〜３モル、好ましくは１．５〜２．５モル用いられる。３モルを超えるアミノ酸を使用しても、製造コストが高くなるだけで経済的でない。 In the preparation of the silver-amino acid complex, the amino acid is used in an amount of 1 to 3 mol, preferably 1.5 to 2.5 mol, with respect to 1 mol of silver in the silver compound. Using more than 3 moles of amino acid is not economical because it only increases the production cost.
銀−アミノ酸錯体の調製における、銀化合物とアミノ酸との好ましい組み合わせは、酸化銀とヒスチジンとの組み合わせである。この組み合わせで調製された銀−アミノ酸錯体は保存安定性に優れている。 A preferred combination of a silver compound and an amino acid in the preparation of a silver-amino acid complex is a combination of silver oxide and histidine. The silver-amino acid complex prepared by this combination is excellent in storage stability.
本発明に用いられる過酸化水素は、酸化剤、酸素系漂白剤として周知の化合物である。また、その水溶液は単独で強い殺菌・抗ウイルス効果を有することが知られており、一般あるいは医療用の殺菌消毒に用いられている。
本発明の抗菌、殺菌若しくは抗ウイルス性組成物では、過酸化水素と併用してまたは過酸化水素に替えて、過酸化水素を発生させる化合物を用いることができる。
Hydrogen peroxide used in the present invention is a well-known compound as an oxidizing agent and an oxygen bleach. In addition, the aqueous solution is known to have a strong sterilization and antiviral effect by itself, and is used for general or medical sterilization.
In the antibacterial, bactericidal or antiviral composition of the present invention, a compound that generates hydrogen peroxide can be used in combination with or in place of hydrogen peroxide.
過酸化水素を発生させる化合物としては、過酸化ナトリウムなどの水との反応で過酸化水素を発生させる化合物；過炭酸ナトリウム、過ホウ酸ナトリウム、過酸化尿素などの過酸化水素を含む付加化合物が挙げられる。これらのうち過酸化ナトリウムが好ましい。過酸化水素を発生させる化合物は、水中では過酸化水素と同様の効果を有する。 Compounds that generate hydrogen peroxide include compounds that generate hydrogen peroxide by reaction with water such as sodium peroxide; addition compounds containing hydrogen peroxide such as sodium percarbonate, sodium perborate, and urea peroxide. Can be mentioned. Of these, sodium peroxide is preferred. A compound that generates hydrogen peroxide has the same effect as hydrogen peroxide in water.
本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、銀−アミノ酸錯体と過酸化水素または過酸化水素を発生させる化合物とを、銀１モルに対して過酸化水素が０．００２〜１０００モルとなる割合、好ましくは０．０２〜５０モルとなる割合で含有している。 In the antibacterial, bactericidal or antiviral composition of the present invention, the silver-amino acid complex and hydrogen peroxide or a compound that generates hydrogen peroxide are used in an amount of 0.002 to 1000 mol of hydrogen peroxide per 1 mol of silver. It is contained at a ratio of preferably 0.02 to 50 mol.
本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、ｐＨが６以上、好ましくは７以上、より好ましくは８以上である。ｐＨの上限は特に制限されないが、好ましくは１２、より好ましくは１１である。なお、該ｐＨは本発明に係る抗菌、殺菌若しくは抗ウイルス性組成物を水に溶解させたときの値である。この範囲のｐＨに調整された抗菌、殺菌若しくは抗ウイルス性組成物は、紫外線を含む光照射下等でも銀の析出等による変色や白濁を起こさないようになる。 The antibacterial, bactericidal or antiviral composition of the present invention has a pH of 6 or more, preferably 7 or more, more preferably 8 or more. The upper limit of the pH is not particularly limited, but is preferably 12 and more preferably 11. The pH is a value when the antibacterial, bactericidal or antiviral composition according to the present invention is dissolved in water. The antibacterial, bactericidal or antiviral composition adjusted to a pH within this range does not cause discoloration or cloudiness due to silver deposition or the like even under irradiation with light including ultraviolet rays.
本発明に係る抗菌、殺菌若しくは抗ウイルス性組成物のｐＨを調整するために、一般に使用されている公知のｐＨ調整剤を使用してもよい。ｐＨ調整剤としては、硫酸、硝酸、水酸化ナトリウム、水酸化カリウム、アンモニア、リン酸塩等が挙げられる。ｐＨを８以上にする場合にはアルカリ性化合物を用いることが好ましい。該アルカリ性化合物は、特に限定されないが、水酸化ナトリウムまたは水酸化カリウムが好ましい。 In order to adjust the pH of the antibacterial, bactericidal or antiviral composition according to the present invention, a commonly used pH adjusting agent that is generally used may be used. Examples of the pH adjuster include sulfuric acid, nitric acid, sodium hydroxide, potassium hydroxide, ammonia, and phosphate. When the pH is 8 or more, it is preferable to use an alkaline compound. The alkaline compound is not particularly limited, but sodium hydroxide or potassium hydroxide is preferable.
本発明に係る抗菌、殺菌若しくは抗ウイルス性組成物を水に溶解させたときに、銀−アミノ酸錯体の濃度が０．０００５質量％〜２０質量％であることが好ましく、０．０５質量％〜１０質量％であることがより好ましく、０．２５質量％〜５質量％であることが特に好ましい。また、本発明に係る抗菌、殺菌若しくは抗ウイルス性組成物を水に溶解させたときに、過酸化水素の濃度が、７０〜３００ｐｐｍであることが好ましい。なお、ここでの濃度は、銀−アミノ酸錯体、過酸化水素、および水の合計量を基準にした値である。 When the antibacterial, bactericidal or antiviral composition according to the present invention is dissolved in water, the concentration of the silver-amino acid complex is preferably 0.0005% by mass to 20% by mass, and 0.05% by mass to It is more preferably 10% by mass, and particularly preferably 0.25% by mass to 5% by mass. Moreover, when the antibacterial, bactericidal or antiviral composition according to the present invention is dissolved in water, the concentration of hydrogen peroxide is preferably 70 to 300 ppm. The concentration here is a value based on the total amount of silver-amino acid complex, hydrogen peroxide, and water.
本発明の抗菌、殺菌若しくは抗ウイルス性組成物には、さらに他の成分が含まれていてもよい。他の成分としては、界面活性剤、有機溶剤、増粘剤、酸化防止剤、光安定剤、香料、消泡剤等が挙げられる。 The antibacterial, bactericidal or antiviral composition of the present invention may further contain other components. Examples of other components include surfactants, organic solvents, thickeners, antioxidants, light stabilizers, fragrances, and antifoaming agents.
界面活性剤としては、アルキルトリメチルアンモニウム塩、ジアルキルジメチルアンモニウム塩、アルキルベンジルジメチルアンモニウム塩、アルキルピリジニウム塩、ポリヘキサメチレンビグアニド等のカチオン性界面活性剤；アルキルベンゼンスルホン酸塩、アルキル硫酸塩、アルキルナフタレンスルホン酸塩、ジアルキルスルホコハク酸塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレンアルキルエーテルカルボン酸塩、ポリオキシエチレンスチレン化フェニルエーテルサルフェートアンモニウム塩、リグニンスルホン酸塩、高級脂肪酸塩、α−オレフィン脂肪酸塩、α−スルホ脂肪酸塩等のアニオン性界面活性剤；アルキルメチルアミンオキシド、アルキルカルボキシベタイン、アルキルスルホベタイン等の両性界面活性剤が挙げられる。 Surfactants include cationic surfactants such as alkyltrimethylammonium salts, dialkyldimethylammonium salts, alkylbenzyldimethylammonium salts, alkylpyridinium salts, polyhexamethylene biguanides; alkylbenzene sulfonates, alkyl sulfates, alkylnaphthalene sulfones Acid salt, dialkylsulfosuccinate, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl ether carboxylate, polyoxyethylene styrenated phenyl ether sulfate ammonium salt, lignin sulfonate, higher fatty acid salt, α-olefin fatty acid salt , Α-sulfo fatty acid salts and other anionic surfactants; amphoteric boundaries such as alkylmethylamine oxide, alkylcarboxybetaine, alkylsulfobetaine A surface active agent is mentioned.
有機溶剤としては、エタノール、イソプロパノール等の低級アルコール；エチレングリコール、プロピレングリコール、ジプロピレングリコール、ポリプロピレングリコール、グリセリン等のグリコール系溶剤；アセトン、メチルエチルケトン、プロピレンカーボネート等のケトン系溶剤；ジメチルホルムアミド、ジメチルスルホキシド、アセトニトリル、Ｎ−メチルピロリドン等の極性溶剤が挙げられる。 Organic solvents include lower alcohols such as ethanol and isopropanol; glycol solvents such as ethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol and glycerin; ketone solvents such as acetone, methyl ethyl ketone and propylene carbonate; dimethylformamide and dimethyl sulfoxide , Polar solvents such as acetonitrile and N-methylpyrrolidone.
増粘剤としては、カルボキシメチルセルロース、キサンタンガム等が挙げられる。
酸化防止剤としては、２，６−ジ−ｔ−ブチル−４−メチルフェノール、２，２’−メチレンビス［４−メチル−６−ｔ−ブチルフェノール］、アルキルジフェニルアミン等が挙げられる。
光安定剤としては、ビス（２，２，６，６−テトラメチル−４−セバケート）等が挙げられる。
Examples of the thickener include carboxymethyl cellulose and xanthan gum.
Examples of the antioxidant include 2,6-di-t-butyl-4-methylphenol, 2,2′-methylenebis [4-methyl-6-t-butylphenol], alkyldiphenylamine, and the like.
Examples of the light stabilizer include bis (2,2,6,6-tetramethyl-4-sebacate).
その他の安定化剤として、ヒドロキシカルボン酸、多価カルボン酸またはそれらの塩が挙げられる。これらのうち、グルクロン酸、クエン酸またはそれらの塩が特に好ましい。これらの安定化剤は特に銀−アミノ酸錯体の光照射による変色を抑制する効果を有し、本発明の抗菌、殺菌若しくは抗ウイルス性組成物の安定化に寄与する。 Examples of other stabilizers include hydroxycarboxylic acids, polyvalent carboxylic acids, and salts thereof. Of these, glucuronic acid, citric acid or their salts are particularly preferred. These stabilizers particularly have an effect of suppressing discoloration of the silver-amino acid complex due to light irradiation, and contribute to stabilization of the antibacterial, bactericidal or antiviral composition of the present invention.
また、本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、その目的および用途に応じて、公知の殺菌防カビ剤、防腐剤、防藻剤等の活性成分が含有されていてもよい。
該活性成分としては、ジデシルジメチルアンモニウムクロライド（ＤＤＡＣ）、ジデシルジメチルアンモニウムアジペート（ＤＤＡＡ）等の第４級アンモニウム塩系化合物、ポリヘキサメチレンビグアニド（ＰＨＭＢ）、グルコン酸クロルへキシジン等のビグアナイド系化合物、セチルピリジニウムクロライド、ドデシルピリジニウムクロライド等のピリジニウム系化合物、１，２−ベンズイソチアゾリン−３−オン、５−クロロ−２−メチル−４−イソチアゾリン−３−オン、２−メチル−４−イソチアゾリン−３−オン、２−ｎ−オクチル−４−イソチアゾリン−３−オン、Ｎ−ｎ−ブチル−１，２−ベンズイソチアゾリン−３−オン等のイソチアゾリン系化合物、３−ヨード−２−プロピニル−ブチルカーバメート等の有機ヨウ素系化合物、２，３，５，６−テトラクロロ−４−（メチルスルホニル）ピリジン等のピリジン系化合物、ジンクピリチオン、ナトリウムピリチオン等のピリチオン系化合物、２−（４−チオシアノメチルチオ）ベンゾチアゾール等のベンゾチアゾール系化合物、メチル−２−ベンズイミダゾールカーバメート、２−（４−チアゾリル）−ベンズイミダゾール等のイミダゾール系化合物、テトラメチルチウラムジスルフィド等のチオカーバメート系化合物、２，４，５，６−テトラクロロイソフタロニトリル等のニトリル系化合物、Ｎ−（フルオロジクロロメチルチオ）−フタルイミドおよびＮ−（フルオロジクロロメチルチオ）−Ｎ，Ｎ’−ジメチル−Ｎ−フェニル−スルファミド等のハロアルキルチオ系化合物、α−ｔ−ブチル−α（ｐ−クロロフェニルエチル）−１Ｈ−１，２，４−トリアゾール−１−エタノール（慣用名テブコナゾール）等のトリアゾール系化合物、３−（３，４−ジクロロフェニル）−１，１−ジメチルウレア（慣用名ＤＣＭＵ）等のフェニルウレア系化合物、２−メチルチオ−４−ｔ−ブチルアミノ−６−シクロプロピルアミノ−Ｓ−トリアジン等のトリアジン系化合物等が挙げられる。
これらの活性成分は、１種単独で若しくは２種以上を組み合わせて使用することができる。またこれら活性成分の配合割合は、用途に応じて任意に決定することができる。
Moreover, the antibacterial, bactericidal or antiviral composition of the present invention may contain active ingredients such as known bactericidal and antifungal agents, antiseptics, and algaeproofing agents according to the purpose and application.
Examples of the active ingredient include quaternary ammonium salt compounds such as didecyldimethylammonium chloride (DDAC) and didecyldimethylammonium adipate (DDAA), biguanides such as polyhexamethylene biguanide (PHMB) and chlorhexidine gluconate. Compounds, pyridinium compounds such as cetylpyridinium chloride, dodecylpyridinium chloride, 1,2-benzisothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazoline- Isothiazoline compounds such as 3-one, 2-n-octyl-4-isothiazolin-3-one, Nn-butyl-1,2-benzisothiazolin-3-one, 3-iodo-2-propynyl-butyl carbamate Organic iodine system such as Products, pyridine compounds such as 2,3,5,6-tetrachloro-4- (methylsulfonyl) pyridine, pyrithion compounds such as zinc pyrithione and sodium pyrithione, and benzoates such as 2- (4-thiocyanomethylthio) benzothiazole Thiazole compounds, imidazole compounds such as methyl-2-benzimidazole carbamate, 2- (4-thiazolyl) -benzimidazole, thiocarbamate compounds such as tetramethylthiuram disulfide, 2,4,5,6-tetrachloroiso Nitrile compounds such as phthalonitrile, haloalkylthio compounds such as N- (fluorodichloromethylthio) -phthalimide and N- (fluorodichloromethylthio) -N, N′-dimethyl-N-phenyl-sulfamide, α-t-butyl -Α (p-chloroph Enylethyl) -1H-1,2,4-triazole-1-ethanol (common name tebuconazole) and other triazole compounds, 3- (3,4-dichlorophenyl) -1,1-dimethylurea (common name DCMU) and the like Examples include phenylurea compounds and triazine compounds such as 2-methylthio-4-t-butylamino-6-cyclopropylamino-S-triazine.
These active ingredients can be used individually by 1 type or in combination of 2 or more types. Moreover, the blending ratio of these active ingredients can be arbitrarily determined according to the application.
本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、その製造方法によって、特に制限されない。本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、例えば、銀化合物とアミノ酸と水とを混合して銀−アミノ酸錯体を調製し、これに過酸化水素または過酸化水素を発生させる化合物を添加し混合することによって、または、粉末状の銀−アミノ酸錯体と水とを混合し、これに過酸化水素または過酸化水素を発生させる化合物を添加し混合することによって得ることができる。抗菌、殺菌若しくは抗ウイルス性組成物の製造に使用される水としては、水道水、精製水、イオン交換水、蒸留水等が挙げられる。これらのうち、安定性や経済性の面から、精製水またはイオン交換水が好ましい。 The antibacterial, bactericidal or antiviral composition of the present invention is not particularly limited by the production method. In the antibacterial, bactericidal or antiviral composition of the present invention, for example, a silver compound, amino acid and water are mixed to prepare a silver-amino acid complex, and hydrogen peroxide or a compound capable of generating hydrogen peroxide is added thereto. Or by mixing a powdery silver-amino acid complex and water, adding hydrogen peroxide or a compound capable of generating hydrogen peroxide to the mixture, and mixing. Examples of the water used for the production of the antibacterial, sterilizing or antiviral composition include tap water, purified water, ion exchange water, distilled water and the like. Of these, purified water or ion-exchanged water is preferred from the viewpoint of stability and economy.
抗菌、殺菌若しくは抗ウイルス性組成物の製造における、各工程は、温度１０〜３０℃の環境下で行うのが好ましい。該組成物を構成する各成分の混合には、公知の撹拌装置を用いることができる。上記の方法等で製造された本発明の抗菌、殺菌若しくは抗ウイルス性組成物は濾過等を行って異物等を取り除くことが好ましい。 Each step in the production of an antibacterial, bactericidal or antiviral composition is preferably performed in an environment at a temperature of 10 to 30 ° C. A known stirrer can be used for mixing the components constituting the composition. The antibacterial, bactericidal or antiviral composition of the present invention produced by the above method is preferably filtered to remove foreign substances.
本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、そのままで若しくは製剤化して、抗菌剤、殺菌剤、抗カビ剤、若しくは抗ウイルス剤として用いることができる。
製剤の形態としては、粉剤、粒剤、ペースト剤、マイクロカプセル剤等が挙げられる。製剤化において、例えば、クレー、タルク、シリカ、アルミナ、モンモリロナイト等に抗菌、殺菌若しくは抗ウイルス性組成物を吸着させることができる。
The antibacterial, bactericidal or antiviral composition of the present invention can be used as an antibacterial agent, bactericidal agent, antifungal agent or antiviral agent as it is or in the form of a preparation.
Examples of the form of the preparation include powders, granules, pastes, microcapsules and the like. In formulation, for example, antibacterial, bactericidal or antiviral composition can be adsorbed on clay, talc, silica, alumina, montmorillonite or the like.
本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、抗菌性、殺菌性、抗カビ性、抗ウイルス性等の効果を必要とする素材に施用することができる。該素材としては、例えば、繊維、衛生加工品、医療用成形加工品、洗剤、化粧品、食品、青果物、種子、農作物、家畜、クリーンフィルム、包装材料、殺菌性材料、水性エマルション塗料、溶剤型塗料、エマルション樹脂、切削油等の金属加工油、合板、木材、皮革、カゼイン、でんぷん糊、にかわ、塗工紙、紙用塗工液、表面サイズ剤、接着剤、合成ゴムラテックス、印刷インキ、ポリビニルアルコールフィルム、塩化ビニルフィルム、プラスチック製品、セメント混和剤、シーリング剤、目地剤などが挙げられる。また、製紙パルプ工場や冷却水循環工程で使用される各種産業用水等にも用いることができる。
施用方法は、対象となる素材に応じて、適宜選択できる。例えば、素材に混ぜ合わせる方法、素材に浸み込ませる方法、素材表面に塗布する方法などが挙げられる。
The antibacterial, bactericidal or antiviral composition of the present invention can be applied to materials that require effects such as antibacterial, bactericidal, antifungal and antiviral properties. Examples of the material include fibers, sanitary processed products, medical molded products, detergents, cosmetics, foods, fruits and vegetables, seeds, agricultural products, livestock, clean films, packaging materials, bactericidal materials, aqueous emulsion paints, solvent-type paints. , Metal processing oil such as emulsion resin, cutting oil, plywood, wood, leather, casein, starch paste, glue, coated paper, paper coating liquid, surface sizing agent, adhesive, synthetic rubber latex, printing ink, polyvinyl Examples include alcohol films, vinyl chloride films, plastic products, cement admixtures, sealing agents, and joint agents. It can also be used for various industrial waters used in paper pulp mills and cooling water circulation processes.
The application method can be appropriately selected depending on the target material. For example, a method of mixing with a material, a method of soaking in a material, a method of applying to the surface of the material, and the like can be mentioned.
（樹脂組成物）
本発明の樹脂組成物は、樹脂と、本発明に係る抗菌、殺菌若しくは抗ウイルス性組成物とを含有するものである。使用する樹脂は、耐久性、耐水性、接着性、耐熱性、耐ブロッキング性、柔軟性等を考慮して適宜選択できる。
本発明の樹脂組成物に用いられる樹脂としては水性樹脂が好ましい。水性樹脂は、水に溶解、又は乳化分散可能な樹脂である。
樹脂はゴム状高分子と樹脂状高分子とに大別される。
ゴム状高分子としては、例えば、天然ゴム、エチレン−プロピレン−ジエンゴム（ＥＰＤＭ）、スチレン−ブタジエンゴム（ＳＢＲ）、クロロプレンゴム（ＣＲ）、アクリロニトリル−ブタジエンゴム（ＮＢＲ）等が挙げられる。
樹脂状高分子としては、例えば、松脂のような天然樹脂、ポリエチレン、スチレン−ブタジエン系樹脂、ポリ酢酸ビニル、エチレン−酢酸ビニル共重合体、ポリ塩化ビニル、ポリビニルブチラール、ポリスチレン、スチレン−ブタジエン系樹脂、ウレタン系樹脂、シリコン系樹脂、アクリル系樹脂等が挙げられる。
(Resin composition)
The resin composition of the present invention contains a resin and the antibacterial, bactericidal or antiviral composition according to the present invention. The resin to be used can be appropriately selected in consideration of durability, water resistance, adhesiveness, heat resistance, blocking resistance, flexibility, and the like.
The resin used in the resin composition of the present invention is preferably an aqueous resin. The aqueous resin is a resin that can be dissolved or emulsified and dispersed in water.
Resins are roughly classified into rubbery polymers and resinous polymers.
Examples of the rubbery polymer include natural rubber, ethylene-propylene-diene rubber (EPDM), styrene-butadiene rubber (SBR), chloroprene rubber (CR), acrylonitrile-butadiene rubber (NBR), and the like.
Examples of the resinous polymer include natural resins such as pine resin, polyethylene, styrene-butadiene resin, polyvinyl acetate, ethylene-vinyl acetate copolymer, polyvinyl chloride, polyvinyl butyral, polystyrene, styrene-butadiene resin. , Urethane resin, silicon resin, acrylic resin and the like.
（塗料）
本発明の塗料は、本発明に係る抗菌、殺菌若しくは抗ウイルス性組成物を含有するものである。本発明の塗料には、通常の塗料に含有されている成分が含まれている。例えば、バインダー、ワックス、顔料、有機溶剤などが挙げられる。バインダーとしては、水性樹脂、有機溶媒分散性樹脂などが挙げられる。バインダーとしてはアクリル系樹脂が好ましい。
(paint)
The paint of the present invention contains the antibacterial, bactericidal or antiviral composition according to the present invention. The paint of the present invention contains components contained in a normal paint. For example, a binder, a wax, a pigment, an organic solvent, etc. are mentioned. Examples of the binder include an aqueous resin and an organic solvent dispersible resin. As the binder, an acrylic resin is preferable.
（金属加工油）
本発明の金属加工油は、本発明に係る抗菌、殺菌若しくは抗ウイルス性組成物を含有するものである。本発明の金属加工油には、通常の金属加工油に含有されている成分が含まれている。例えば、シリコンカーバイド，ダイヤモンド，アルミナ等の砥粒、防錆剤、酸化ポリエチレン，ポリカルボン酸等のワックス、鉱物油，合成炭化水素油，エステル油，植物油などの油類、界面活性剤、消泡剤、防腐剤、無機塩類、極圧添加剤などが挙げられる。
(Metal processing oil)
The metalworking oil of the present invention contains the antibacterial, bactericidal or antiviral composition according to the present invention. The metal processing oil of the present invention contains components contained in ordinary metal processing oil. For example, abrasive grains such as silicon carbide, diamond and alumina, rust preventive agent, wax such as polyethylene oxide and polycarboxylic acid, oils such as mineral oil, synthetic hydrocarbon oil, ester oil and vegetable oil, surfactant, defoaming agent Agents, preservatives, inorganic salts, extreme pressure additives and the like.
（接着剤）
本発明の接着剤は、本発明に係る抗菌、殺菌若しくは抗ウイルス性組成物を含有するものである。本発明の接着剤には、通常の接着剤に含有されている成分が含まれている。例えば、接着性樹脂、有機溶剤、性能を改良するための付加的樹脂、可塑剤、接着助剤、安定剤、着色剤、界面活性剤、導電性付与剤などが挙げられる。接着性樹脂としては、エポキシ樹脂などの熱硬化性樹脂、熱可塑性樹脂などが挙げられる。
(adhesive)
The adhesive of the present invention contains the antibacterial, bactericidal or antiviral composition according to the present invention. The adhesive of the present invention contains components contained in a normal adhesive. Examples thereof include an adhesive resin, an organic solvent, an additional resin for improving performance, a plasticizer, an adhesion aid, a stabilizer, a colorant, a surfactant, and a conductivity imparting agent. Examples of the adhesive resin include a thermosetting resin such as an epoxy resin, a thermoplastic resin, and the like.
（その他の製品）
本発明の抗菌、殺菌若しくは抗ウイルス性組成物を含有する製品は、前記施用方法のいずれかにより本発明の抗菌、殺菌若しくは抗ウイルス性組成物を直接施用する方法で製造してもよいし、本発明の樹脂組成物、塗料、接着剤等を材料とする方法で製造してもよいし、また以上の両方法を組み合わせる方法で製造してもよい。例えば、本発明の抗菌、殺菌若しくは抗ウイルス性組成物を含有する樹脂組成物を用いて製造した塗料等の製品、本発明の抗菌、殺菌若しくは抗ウイルス性組成物を含有する樹脂組成物を成型して製造した製品、あるいは、前記樹脂成型品もしくはその他の素材からなる物品に本発明の塗料、接着剤等を施用して製造した製品等が含まれる。
(Other products)
The product containing the antibacterial, bactericidal or antiviral composition of the present invention may be manufactured by a method of directly applying the antibacterial, bactericidal or antiviral composition of the present invention by any of the above application methods, You may manufacture by the method which uses the resin composition of this invention, a coating material, an adhesive agent, etc. as a material, and you may manufacture by the method of combining both the above methods. For example, molding a resin composition containing the antibacterial, bactericidal or antiviral composition of the present invention, a product such as a paint manufactured using the resin composition containing the antibacterial, bactericidal or antiviral composition of the present invention Products manufactured by applying the paint, adhesive or the like of the present invention to the above-mentioned resin molded products or other articles made of other materials.
次に、実施例を示し、本発明をより具体的に説明する。ただし、本発明は、これら実施例により限定されるものではない。 Next, an Example is shown and this invention is demonstrated more concretely. However, the present invention is not limited to these examples.
〈使用した薬品等〉
酸化銀：試薬特級 和光純薬社製
Ｌ−ヒスチジン：試薬特級 和光純薬社製
クエン酸３ナトリウム：試薬特級 和光純薬社製
クエン酸：試薬特級 和光純薬社製
過酸化水素：試薬特級 和光純薬社製
過酸化ナトリウム：試薬特級 和光純薬社製
水酸化ナトリウム：試薬特級 和光純薬社製
水酸化カリウム：試薬特級 和光純薬社製
塩化ナトリウム：試薬特級 和光純薬社製
ニュートリエントブロス：普通ブイヨン「栄研」栄研化学社製
<Used chemicals>
Silver oxide: Reagent special grade Wako Pure Chemical Industries L-histidine: Reagent special grade Wako Pure Chemical Industries, Ltd. Trisodium citrate: Reagent special grade Wako Pure Chemical Industries, Ltd. Citric acid: Reagent special grade Wako Pure Chemical Industries, Ltd. Hydrogen peroxide: Reagent special grade Japan Sodium peroxide manufactured by Kojun Pharmaceutical Co., Ltd .: Special grade manufactured by Wako Pure Chemical Industries, Ltd. Sodium hydroxide: Special grade manufactured by Wako Pure Chemical Industries, Ltd. Potassium hydroxide: Special grade manufactured by Wako Pure Chemical Industries, Ltd. Sodium chloride: Special grade manufactured by Wako Pure Chemical Industries, Ltd. Nutrient Broth : Ordinary bouillon “Eiken” manufactured by Eiken Chemical Co., Ltd.
実施例１
ビーカーに、酸化銀１．０７４ｇ、Ｌ−ヒスチジン２．８８ｇ、クエン酸３ナトリウム０．４ｇ、クエン酸０．４ｇおよび水９５．６４６ｇを入れ、室温で３０分間以上攪拌し、ヒスチジン銀錯体２．４４重量％（銀として約１．００重量％）を含有するヒスチジン銀錯体溶液（ｐＨ６．８）１体積部を得た。
この溶液に６２６ｍｇ／Ｌの過酸化水素水１体積部を加え攪拌し、ヒスチジン銀錯体１．２２重量％（銀として０．５重量％）を含有する組成物（ｐＨ７．０）を得た。
Example 1
In a beaker, 1.074 g of silver oxide, 2.88 g of L-histidine, 0.4 g of trisodium citrate, 0.4 g of citric acid, and 95.646 g of water were stirred at room temperature for 30 minutes or more. 1 part by volume of a histidine silver complex solution (pH 6.8) containing 44% by weight (about 1.00% by weight as silver) was obtained.
To this solution was added 1 volume part of 626 mg / L hydrogen peroxide solution and stirred to obtain a composition (pH 7.0) containing 1.22% by weight of histidine silver complex (0.5% by weight as silver).
実施例２
実施例１と同じ方法によって得られたヒスチジン銀錯体溶液１体積部に、６２６ｍｇ／Ｌの過酸化ナトリウム水溶液１体積部を加え攪拌し、ヒスチジン銀錯体１．２２重量％（銀として０．５重量％）を含有する組成物（ｐＨ８．０）を得た。
Example 2
1 part by volume of a 626 mg / L sodium peroxide aqueous solution was added to 1 part by volume of the histidine silver complex solution obtained by the same method as in Example 1, and the mixture was stirred to give 1.22% by weight of histidine silver complex (0.5% by weight as silver). %) Was obtained (pH 8.0).
実施例３
実施例１と同じ方法によって得られたヒスチジン銀錯体溶液１体積部に、３２０ｍｇ／Ｌの過酸化水素水０．５体積部および２５６０ｍｇ／Ｌの水酸化ナトリウム水溶液０．５体積部を加え攪拌し、ヒスチジン銀錯体１．２２重量％（銀として０．５重量％）を含有する組成物（ｐＨ９．０）を得た。
Example 3
To 1 volume part of the histidine silver complex solution obtained by the same method as in Example 1, 0.5 volume part of 320 mg / L hydrogen peroxide solution and 0.5 volume part of 2560 mg / L sodium hydroxide aqueous solution were added and stirred. A composition (pH 9.0) containing 1.22% by weight of histidine silver complex (0.5% by weight as silver) was obtained.
実施例４
実施例１と同じ方法によって得られたヒスチジン銀錯体溶液１体積部に、３２０ｍｇ／Ｌの過酸化水素水０．５体積部および２５６０ｍｇ／Ｌの水酸化カリウム水溶液を０．５体積部を加え攪拌し、ヒスチジン銀錯体１．２２重量％（銀として０．５重量％）を含有する組成物（ｐＨ９．０）を得た。
Example 4
To 1 volume part of the histidine silver complex solution obtained by the same method as in Example 1, 0.5 volume part of 320 mg / L hydrogen peroxide solution and 0.5 volume part of 2560 mg / L potassium hydroxide aqueous solution were added and stirred. As a result, a composition (pH 9.0) containing 1.22% by weight of histidine silver complex (0.5% by weight as silver) was obtained.
比較例１
ビーカーに、酸化銀１．０７４ｇ、Ｌ−ヒスチジン２．８８ｇおよび水９６．０４６ｇを入れ、室温で３０分間以上攪拌し、ヒスチジン銀錯体２．４４重量％を含有する溶液（ｐＨ７．９）１体積部を得た。これに水１体積部を加え攪拌し、ヒスチジン銀錯体１．２２重量％（銀として０．５重量％）を含有する組成物（ｐＨ７．９）を得た。
Comparative Example 1
A beaker was charged with 1.074 g of silver oxide, 2.88 g of L-histidine and 96.046 g of water, stirred at room temperature for 30 minutes or more, and 1 volume of a solution (pH 7.9) containing 2.44% by weight of a histidine silver complex. Got a part. One volume part of water was added to this and stirred to obtain a composition (pH 7.9) containing 1.22% by weight of histidine silver complex (0.5% by weight as silver).
比較例２
実施例１と同じ方法によって得られたヒスチジン銀錯体溶液１体積部に、水１体積部を加え攪拌し、ヒスチジン銀錯体１．２２重量％（銀として０．５重量％）を含有する組成物（ｐＨ６．８）を得た。
Comparative Example 2
A composition containing 1.22% by weight of histidine silver complex (0.5% by weight as silver) by adding 1 part by volume of water to 1 part by volume of the histidine silver complex solution obtained by the same method as in Example 1. (PH 6.8) was obtained.
比較例３
実施例１と同じ方法によって得られたヒスチジン銀錯体溶液１体積部に、２５６０ｍｇ／Ｌの水酸化ナトリウム水溶液１体積部を加え攪拌し、ヒスチジン銀錯体１．２２重量％（銀として０．５重量％）を含有する組成物（ｐＨ９．０）を得た。
Comparative Example 3
To 1 part by volume of the histidine silver complex solution obtained by the same method as in Example 1, 1 part by volume of a 2560 mg / L sodium hydroxide aqueous solution was added and stirred, and 1.22% by weight of histidine silver complex (0.5% by weight as silver). %) Was obtained (pH 9.0).
上記の実施例および比較例で得られた組成物の保存安定性と殺菌性とを以下の手順にて評価した。 The storage stability and bactericidal properties of the compositions obtained in the above Examples and Comparative Examples were evaluated by the following procedure.
（保存安定性試験）
ガラス試験管にヒスチジン銀錯体を含有する組成物１体積部を入れ、これに精製水または塩化ナトリウム水溶液（塩化物イオンの最終濃度は１ｍｇ／Ｌ）１体積部を加えて混合し、試験管を栓で密封し、蛍光灯照射下（４０００Ｌｕｘ）、２５℃にて１週間放置した。次いで外観を観察し、以下の評価基準で評価した。各組成物の評価結果を表１に示す。
〔評価基準〕
ＡＡ：均一透明で変色なし
Ａ ：均一透明だがわずかな変色あり
Ｂ ：均一微濁または変色
Ｃ ：激しい変色、沈殿またはガラス器壁への付着物あり
(Storage stability test)
Place 1 part by volume of a composition containing a histidine silver complex in a glass test tube, add 1 part by volume of purified water or an aqueous sodium chloride solution (final concentration of chloride ion is 1 mg / L), and mix. The tube was sealed with a stopper and allowed to stand at 25 ° C. for 1 week under fluorescent lamp irradiation (4000 Lux). Next, the appearance was observed and evaluated according to the following evaluation criteria. The evaluation results of each composition are shown in Table 1.
〔Evaluation criteria〕
AA: Uniformly transparent and no discoloration A: Uniformly transparent but slight discoloration B: Uniform turbidity or discoloration C: Severe discoloration, precipitation or deposits on glassware walls
（殺菌性試験）
ニュートリエントブロス液体培地９ｍｌに、白金耳によりかきとった大腸菌または黄色ブドウ球菌のコロニー（１白金耳）を懸濁し、３１±１℃で１８時間振盪による前培養を行なった。この培養液を新鮮なニュートリエントブロス培地で１００倍に希釈した。該希釈液１００μＬを９６穴のマイクロプレートに入れた。
これに、実施例１〜４および比較例２で得られた組成物を表２または表３に表示した設定濃度に精製水で希釈して得た試験液各５０μＬを加えた。マイクロプレートを３１±１℃の環境下にて４８時間置き、培養した。該培養液を寒天含有培地に接種して菌が増殖するか否かで、菌の増殖の有無を判断した。なお、表２および表３において銀濃度０ｍｇ／Ｌは、試験液の代わりに精製水を加えたことを意味する。
表２に大腸菌の結果を、表３に黄色ブドウ球菌の結果をそれぞれ示す。表中の「＋」は菌の増殖有りを、「−」は菌の増殖無しを示す。
(Bactericidal test)
Escherichia coli or Staphylococcus aureus colonies (1 platinum loop) scraped with a platinum loop were suspended in 9 ml of a nutrient broth liquid medium, and precultured by shaking at 31 ± 1 ° C. for 18 hours. This culture was diluted 100-fold with fresh nutrient broth medium. 100 μL of the diluted solution was placed in a 96-well microplate.
50 μL of each test solution obtained by diluting the compositions obtained in Examples 1 to 4 and Comparative Example 2 with purified water to the set concentrations shown in Table 2 or Table 3 was added thereto. The microplate was placed in an environment of 31 ± 1 ° C. for 48 hours and cultured. The presence or absence of bacterial growth was determined by inoculating the culture solution on agar-containing medium and determining whether the bacteria grew. In Tables 2 and 3, a silver concentration of 0 mg / L means that purified water was added instead of the test solution.
Table 2 shows the results for E. coli, and Table 3 shows the results for S. aureus. In the table, “+” indicates the presence of bacterial growth, and “−” indicates the absence of bacterial growth.
表１と表２および表３とに示した通り、本発明の抗菌、殺菌若しくは抗ウイルス性組成物は、紫外線や塩化物イオンに対する耐性が高く、保存安定性に優れていることがわかる。しかも、安定化処理をしても殺菌活性等の低下がない。 As shown in Table 1, Table 2 and Table 3, it can be seen that the antibacterial, bactericidal or antiviral composition of the present invention has high resistance to ultraviolet rays and chloride ions and is excellent in storage stability. Moreover, even if the stabilization treatment is performed, the bactericidal activity does not decrease.
Claims (15)
過酸化水素または過酸化水素を発生させる化合物とを、
銀１モルに対して過酸化水素が０．００２〜１０００モルとなる割合で含有し、且つｐＨが６以上である、抗菌、殺菌若しくは抗ウイルス性組成物。 A silver-amino acid complex consisting of 1 mol of silver and 1-3 mol of amino acid;
Hydrogen peroxide or a compound that generates hydrogen peroxide,
An antibacterial, bactericidal or antiviral composition containing hydrogen peroxide in a proportion of 0.002 to 1000 mol per mol of silver and having a pH of 6 or more.
ｐＨを６以上に調整することを含む、抗菌、殺菌若しくは抗ウイルス性組成物の製造方法。 Hydrogen peroxide or a compound that generates hydrogen peroxide in a silver-amino acid complex consisting of 1 mol part of silver and 1 to 3 mol parts of amino acid is 0.002 to 1000 mol of hydrogen peroxide per 1 mol of silver. A method for producing an antibacterial, bactericidal or antiviral composition, comprising mixing at a ratio and adjusting the pH to 6 or more.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102504615A (en) * | 2011-11-17 | 2012-06-20 | 中国科学院宁波材料技术与工程研究所 | Antibacterial agent preparation method for antibacterial plastic product |
| JP2012144438A (en) * | 2011-01-06 | 2012-08-02 | Nippon Soda Co Ltd | Scalp hair cosmetic |
| JP2018154601A (en) * | 2017-03-21 | 2018-10-04 | 日本曹達株式会社 | Antiviral agent and use therefor |
| JP2019006744A (en) * | 2017-06-28 | 2019-01-17 | 日本碍子株式会社 | Bactericidal water, and production method of bactericidal water |
| CN111484421A (en) * | 2020-04-29 | 2020-08-04 | 洛阳冠银生物科技有限公司 | Antibacterial silver ion compound, non-irritant silver ion antibacterial agent and preparation method and application thereof |
| CN115335353A (en) * | 2020-06-23 | 2022-11-11 | 佐佐木化学工业株式会社 | Hydrogen-bis-silver citrate-containing composition and method for producing same, and antibacterial agent or antiviral agent using same and method for producing same |
| WO2024005163A1 (en) * | 2022-06-30 | 2024-01-04 | 株式会社キャスティングイン | Antibacterial composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08225418A (en) * | 1986-04-22 | 1996-09-03 | Sanosil Ag | Disinfectant |
| JPH11302119A (en) * | 1998-04-24 | 1999-11-02 | Daiso Co Ltd | Production of antimicrobial silver colloid |
| WO2009098850A1 (en) * | 2008-02-08 | 2009-08-13 | Nippon Soda Co., Ltd. | Liquid composition comprising histidine-silver complex, germicidal agent composition, and method for stabilization of histidine-silver complex |
-
2011
- 2011-02-25 JP JP2011039290A patent/JP5718092B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08225418A (en) * | 1986-04-22 | 1996-09-03 | Sanosil Ag | Disinfectant |
| JPH11302119A (en) * | 1998-04-24 | 1999-11-02 | Daiso Co Ltd | Production of antimicrobial silver colloid |
| WO2009098850A1 (en) * | 2008-02-08 | 2009-08-13 | Nippon Soda Co., Ltd. | Liquid composition comprising histidine-silver complex, germicidal agent composition, and method for stabilization of histidine-silver complex |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012144438A (en) * | 2011-01-06 | 2012-08-02 | Nippon Soda Co Ltd | Scalp hair cosmetic |
| CN102504615A (en) * | 2011-11-17 | 2012-06-20 | 中国科学院宁波材料技术与工程研究所 | Antibacterial agent preparation method for antibacterial plastic product |
| CN102504615B (en) * | 2011-11-17 | 2013-08-07 | 中国科学院宁波材料技术与工程研究所 | Antibacterial agent preparation method for antibacterial plastic product |
| JP2018154601A (en) * | 2017-03-21 | 2018-10-04 | 日本曹達株式会社 | Antiviral agent and use therefor |
| JP2019006744A (en) * | 2017-06-28 | 2019-01-17 | 日本碍子株式会社 | Bactericidal water, and production method of bactericidal water |
| CN111484421A (en) * | 2020-04-29 | 2020-08-04 | 洛阳冠银生物科技有限公司 | Antibacterial silver ion compound, non-irritant silver ion antibacterial agent and preparation method and application thereof |
| CN115335353A (en) * | 2020-06-23 | 2022-11-11 | 佐佐木化学工业株式会社 | Hydrogen-bis-silver citrate-containing composition and method for producing same, and antibacterial agent or antiviral agent using same and method for producing same |
| CN115335353B (en) * | 2020-06-23 | 2023-06-09 | 佐佐木化学工业株式会社 | Composition containing hydrogen citrate and dipsilver, process for producing the same, and antibacterial agent or antiviral agent using the same and process for producing the same |
| WO2024005163A1 (en) * | 2022-06-30 | 2024-01-04 | 株式会社キャスティングイン | Antibacterial composition |
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