JP2011195581A - Composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition which does not aggregate or precipitate without containing an organic solvent, when stored under a frozen or prefrozen state, and is excellent in physiological activities such as algaecidal and fungicidal properties.SOLUTION: The composition comprises a triazine-based compound such as 2-methylthio-4-t-butylamino-6-cyclopropylamino-s-triazine, an isothiazoline-based compound such as 2-n-octyl-4-isothiazoline-3-one, an alkylsulfosuccinic acid-based surfactant, an alkylphenyl ether-based surfactant, and a polyoxyethylene sorbitan fatty acid ester-based surfactant.

Description

  The present invention relates to a composition. In more detail, this invention relates to the composition suitable for the coating-material use etc. which were excellent in storage stability.

Algae and fungi can grow on the outer walls, hulls, and waterways of buildings, resulting in problems such as loss of appearance and function. In order to prevent this, it is widely performed to paint on the outer wall or the like using a paint containing an algae or fungicide.
As an algae-proofing agent and a fungicide used in such paints, an algae- and fungicide composition containing both a triazine-type algae-proof agent and an isothiazoline-type fungicide is known.

  For example, Patent Document 1 discloses a triazine compound such as 2-methylthio-4-t-butylamino-6-cyclopropylamino-s-triazine as a specific example of an antibacterial and antifungal alga-proof composition, 2-n- Suspensions containing isothiazoline compounds such as octyl-4-isothiazolin-3-one, nonionic surfactants and water are disclosed.

  Patent Document 2 discloses a microcapsule aqueous dispersant in which an oil phase containing an isothiazoline compound such as 2-n-octyl-4-isothiazolin-3-one is dispersed in an aqueous phase containing an anionic surfactant, -A microcapsule aqueous dispersion in which an oil phase containing a triazine compound such as methylthio-4-t-butylamino-6-cyclopropylamino-s-triazine is dispersed in an aqueous phase containing an anionic surfactant An anti-algae agent is disclosed.

  Patent Document 3 discloses an algal control agent containing an algicidal triazine compound, a bactericidal isothiazolone compound, a dispersion stabilizer and a functional additive. As the dispersion stabilizer, sulfite and the like are shown. Nonionic surfactants are shown as functional additives.

  Patent Document 4 discloses 4,5-dichloro-2-n-octylisothiazolin-3-one, 2-methylthio-4-t-butylamino-6-cyclopropylamino-S-triazine compound, and methyl-2. An antifungal anti-algae composition containing benzimidazole carbamate, polyoxyethylene alkyl ether, polyoxyethylene styryl phenyl sulfate, and water is disclosed.

  As a composition containing a combination of a plurality of surfactants, for example, Patent Document 5 discloses a fatty acid ester of a polyhydric alcohol such as sorbitan monooleate, glycerin monostearate, sorbitan monostearate, and polyoxyethylene alkyl. Agrochemical compositions containing surfactants such as phenyl ether formalin condensate, polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether and the like are disclosed.

  Patent Document 6 discloses a composition containing polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether and dicetylsulfosuccinate soda salt, polyoxyethylene sorbitan monopalmitate, sorbitan monopalmitate and stearoylmethyltaurine sodium. A composition containing a salt is disclosed.

  Patent Document 7 contains a surfactant such as polyoxyethylene alkylphenyl ether, polyoxyethylene sorbitan fatty acid ester and the like in which the ethylene oxide group represents 70% by mass or more of the total mass, and a dialkyl sulfosuccinate. An energy ray curable oil-in-water emulsion is disclosed.

JP-A-11-116410 JP 2002-316903 A JP 2004-131478 A JP 2006-335707 A JP-A-5-155706 JP 2009-84489 A JP 2005-239803 A

Physiologically active substances include substances that are hardly soluble in water, such as triazine compounds and isothiazoline compounds. In addition, many physiologically active substances are solid at room temperature, such as triazine compounds. Therefore, when the aqueous suspension described in Patent Document 1 is stored at a low temperature just before freezing, physiologically active substances such as triazine compounds or isothiazoline compounds aggregate and precipitate. Sometimes. If the physiologically active substance is aggregated, physiological activity such as anti-algae and mold may be reduced. Conventionally, an organic solvent has been added to prevent this aggregation, but the use of this organic solvent is being restricted due to concern about the environmental impact of this organic solvent.
Therefore, the present invention provides a composition that does not contain an organic solvent and does not cause aggregation or precipitation when stored under freezing or pre-freezing conditions. It is a problem to provide an excellent composition.

As a result of intensive studies to solve the above problems, the present inventors have found that a composition containing a surfactant in a specific combination does not cause aggregation or particle growth of a physiologically active substance or the like even when frozen. I found.
The present invention has been completed by further studies based on this finding.

That is, the present invention includes the following.
[1] A composition containing a triazine compound, an isothiazoline compound, an alkylsulfosuccinic acid surfactant, an alkylphenyl ether surfactant, and a polyoxyethylene sorbitan fatty acid ester surfactant.
[2] The composition according to [1], wherein the amount of the isothiazoline compound is more than 0 parts by mass and less than 1 part by mass with respect to 1 part by mass of the triazine compound.
[3] The total amount of the alkylsulfosuccinic acid surfactant, the alkylphenyl ether surfactant, and the polyoxyethylene sorbitan fatty acid ester surfactant is 0.1 part by mass with respect to 1 part by mass of the triazine compound. The composition according to [1] or [2], which is more and 1 part by mass or less.

[4] The triazine compound is 2-methylthio-4-tert-butylamino-6-cyclopropylamino-s-triazine, 2-methylthio-4-tert-butylamino-6-ethylamino-s-triazine, 2 -Chloro-4,6-diethylamino-s-triazine, 2-chloro-4-ethylamino-6-isopropylamino-s-triazine, and 2-methylthio-4-ethylamino-6- (1,2-dimethylpropyl) The composition according to any one of [1] to [3], which is at least one selected from the group consisting of (amino) -s-triazine.
[5] The isothiazoline-based compound is 2-n-octyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, 5-chloro-2-n-octyl-4- Selected from the group consisting of isothiazoline-3-one, 4-chloro-2-n-octyl-4-isothiazolin-3-one, and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one The composition according to any one of [1] to [4], which is at least one kind.
[6] The composition according to any one of [1] to [5], wherein the composition is an anti-algal and anti-fungal composition.

[7] A composition comprising an alkylsulfosuccinic acid surfactant, an alkylphenyl ether surfactant, and a polyoxyethylene sorbitan fatty acid ester surfactant.

[8] A composition comprising a physiologically active substance, an alkylsulfosuccinic acid surfactant, an alkylphenyl ether surfactant, and a polyoxyethylene sorbitan fatty acid ester surfactant.
[9] The composition according to [8], further comprising a solvent, wherein the solvent is composed of only water.
[10] The composition according to [8] or [9] above, wherein the physiologically active substance is a water-insoluble compound.
[11] The composition according to any one of [8] to [10], wherein the physiologically active substance is either a triazine compound or an isothiazoline compound.

[12] Any one of [1] to [11] above, wherein the alkylphenyl ether surfactant is 1 part by mass to 5 parts by mass with respect to 1 part by mass of the alkylsulfosuccinic acid surfactant. A composition according to 1.
[13] Any of [1] to [12] above, wherein the polyoxyethylene sorbitan fatty acid ester surfactant is 1 part by mass to 5 parts by mass with respect to 1 part by mass of the alkylsulfosuccinic acid surfactant. The composition according to claim 1.

[14] A paint containing the composition according to any one of [1] to [13].

Even if it does not contain an organic solvent, the composition according to the present invention does not cause aggregation or particle growth when stored for a long time when frozen or at a low temperature, and can be stably stored for a long time. Since it is not necessary to use an organic solvent, the environmental impact can be reduced.
When a triazine compound, an isothiazoline compound, or the like is used as a physiologically active substance, the composition according to the present invention can stably obtain physiological activities such as antialgae and mold prevention.

1 is a graph showing the particle size distribution of an aqueous suspension preparation A obtained in Example 1. FIG. FIG. 3 is a view showing a particle size distribution of an aqueous suspension preparation B obtained in Comparative Example 1. 6 is a graph showing the particle size distribution of an aqueous suspension preparation C obtained in Comparative Example 2. FIG.

  The composition according to the present invention contains an alkylsulfosuccinic acid surfactant, an alkylphenyl ether surfactant, and a polyoxyethylene sorbitan fatty acid ester surfactant.

  The alkylsulfosuccinic acid surfactant used in the present invention is not particularly limited, and examples thereof include sodium dioctylsulfosuccinate, sodium dihexylsulfosuccinate, potassium dinonylsulfosuccinate and the like. These can be used alone or in combination of two or more.

The alkylphenyl ether surfactant used in the present invention is not particularly limited, but polyoxyethylene styryl phenyl ether, polyoxyethylene benzyl phenyl ether, polyoxyethylene nonyl phenyl ether, polyoxypropylene benzyl phenyl An ether etc. can be illustrated. These can be used alone or in combination of two or more.
The amount of the alkylphenyl ether surfactant is preferably 1 part by weight and 5 parts by weight, more preferably 1.5 parts by weight and 3 parts by weight with respect to 1 part by weight of the alkylsulfosuccinic acid surfactant. It is as follows.

Polyoxyethylene sorbitan fatty acid ester surfactant used in the present invention is not particularly limited, but polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan tristearate, Examples thereof include polyoxyethylene sorbitan monooleate and polyoxyethylene sorbitan trioleate. These can be used alone or in combination of two or more.
The amount of the polyoxyethylene sorbitan fatty acid ester surfactant is preferably 1 part by weight and 5 parts by weight, more preferably 1.5 parts by weight and more, with respect to 1 part by weight of the alkylsulfosuccinic acid surfactant. 3 parts by mass or less.
The combination of the above three kinds of surfactants improves the stability of the composition of the present invention at low temperatures.

  The composition of the present invention may contain a surfactant other than the above-described surfactants as necessary as long as the effects of the present invention are not impaired. Examples of such surfactants include polyoxyethylene fatty acid esters; polyoxyethylene alkyl ethers; acetylene glycols; sodium phthalene sulfonic acid formaldehyde condensate sodium salt, melamine sulfonic acid formaldehyde condensate sodium salt and the like Alkyl sulfates such as sodium cetyl sulfate and sodium dodecyl sulfate; sulfonates such as sodium alkylbenzene sulfonate and sodium lignin sulfonate;

  A preferred composition according to the present invention further contains a physiologically active substance. The preferred composition according to the present invention further contains a solvent, and the solvent consists only of water.

The physiologically active substance used in the present invention is preferably a compound that is insoluble in water.
Examples of the physiologically active substance used in the present invention include vitamins, hormones, enzymes, nucleic acids, urea, sulfur, kojic acid and derivatives thereof; medicines;

As vitamins, vitamin A such as retinol, retinol acetate, retinol palmitate; vitamin B ₂ such as riboflavin and riboflavin butyrate; pyridoxine, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dicaprate, pyridoxine dilaurate, dipalmitic acid Vitamin B ₆ composed of acylated pyridoxine such as pyridoxine and pyridoxine tripalmitate; ascorbic acid and its salts, ascorbyl phosphate and its salts, ascorbyl stearate, ascorbyl distearate, ascorbyl palmitate, ascorbyl dipalmitate, tri Vitamin Cs such as ascorbyl palmitate, ascorbyl diisopalmitate, ascorbyl dioleate; calcium pantothenate, D-pan Pantothenic acids such as tothenyl alcohol, pantothenyl ethyl ether and acetyl pantothenyl ethyl ether; vitamin Ds such as ergocalciferol and cholecalciferol; nicotinic acids such as nicotinic acid, nicotinic acid amide and benzyl nicotinate; α-tocopherol Vitamin E such as tocopherol acetate; vitamin P, biotin and the like.

  Hormones include follicular hormones such as estradiol, estrone, estriol, echirin, ethinyl estradiol; lutein hormones such as pregnenolone and progesterone; 11-deoxycorticosterone, corticosterone, aldosterone, 17α-hydroxyprogesterone, 11- Examples include corticosteroids such as deoxycortisol, cortisol, cortisone, hydrocortisone, prednisone, and 9-α-hydrofluorocortisone.

  Examples of the enzyme include protease, lipase, superoxide dismutase, lysozyme, alkaline phosphatase, glutathione peroxidase, catalase, and amylase.

  Examples of drugs include analgesics, antipyretic analgesics, headache treatments, antitussives, expectorants, sedatives, antispasmodics, antihistamines, antiallergic agents, antiplasmin agents, bronchodilators, asthma treatments, diabetes treatments , Liver disease treatment agent, ulcer treatment agent, gastritis treatment agent, healthy stomach digestive agent, gastrointestinal motility activator, hypertension treatment agent, angina pectoris treatment agent, antihypertensive agent, hypotension treatment agent, hyperlipidemia treatment agent , Hormonal agents, antibiotics, antiviral agents, sulfa drugs, anti-inflammatory agents, neuropsychiatric agents, intraocular pressure-lowering agents, antiemetics, antidiarrheals, gout treatment agents, arrhythmia treatment agents, vasoconstrictors, digestive agents, sleep or Hypnotic induction (induction) agent, sympathetic blocking agent, anemia treatment agent, antiepileptic agent, anti-vertigo agent, parallel injury treatment agent, tuberculosis treatment agent, vitamin deficiency treatment agent, dementia treatment agent, urinary incontinence treatment agent, antidepressant Mouth bactericides, parasite control agents, vitamins, Mino acids, such as minerals and the like.

  More specifically, for example, central nervous system drugs (acetaminophen, aspirin, indomethacin, ibuprofen, naproxen, diclofenac sodium, meclofenoxate hydrochloride, chlorpromazine, sodium tolmethine, milnacipran hydrochloride, phenobarbital, etc.) Peripheral nervous system drugs (etomidrine, tolperisone hydrochloride, ethyl pipetanate bromide, methylbenactidium bromide, furopropion, etc.), hemostatic drugs (sodium carbazochrome sulfonate, protamine sulfate, etc.), drugs for cardiovascular system (aminophylline, Such as ethylephrine hydrochloride, diltiazem hydrochloride, digitoxin, captopril), respiratory drugs (ephedrine hydrochloride, chlorprenalin hydrochloride, oxerazine citrate, cloperastine, sodium cromoglycate, etc.) Organ drugs (berberine chloride, loperamide hydrochloride, cimetidine, ranitidine hydrochloride, famotidine, etc.), coronary vasodilators (nifedipine, nicardipine, verapamil, etc.), vitamins (ascorbic acid, thiamine hydrochloride, calcium pantothenate, riboflavin, etc.), Metabolic preparations (camostat mesilate, mizoribine, lysozyme chloride, etc.), allergic drugs (cyproheptadine hydrochloride, diphenhydramine hydrochloride, alimemazine tartrate, suplatast tosylate, diphenhydramine maleate, etc.), chemotherapeutic agents (acyclovir, enoxacin, ofloxacin, pipemetic acid) Trihydrate, levofloxacin, etc.), antibiotics (erythromycin, cefcapene pivoxil hydrochloride, cefteram pivoxil, cefpodoxime proxetil, cefaclor) Cephalexin, clarithromycin, Rokitamycin) and the like.

As agricultural and horticultural agents, antibacterial agents, antiviral agents, fungicides, acaricides, insecticides, nematicides, rodenticides, herbicides, plant growth regulators, fertilizers, safeners, repellents, chitin synthesis inhibition And insect growth control agents.
Insecticides include pyrethroid compounds such as cyfluthrin, cypermethrin, deltamethrin, fenpropatoline, fenvalerate, esfenvalerate, tralomethrin, acrinathrin, bifenthrin, resmethrin, tetramethrin; propoxer, isoprocarb, xylylcarb, metolcarb, XMC, carbaryl Carbamate compounds such as pirimicarb, carbofuran, mesomil, phenoxycarb, alanibcarb, methoxadiazone; acephate, phentoate, bamidithione, trichlorphone, monocrotophos, tetrachlorvinphos, dimethylvinphos, fosarone, chlorpyrifos, chlorpyrifosmethyl, pyridafenthion, quinalphos, thionalmethione , Methamidophos, dimethoate, fermo Organic phosphorus compounds such as ON, azinephosethyl, azinephosmethyl, salicione; diflubenzuron, chlorfluazuron, rufenuron, hexaflumuron, flufenoxuron, flucycloxuron, cyromazine, diafenthiuron, hexithazox, novallon, teflubenzuron, triflumuuron 4-chloro-2- (2-chloro-2-methylpropyl) -5- (6-iodo-3-pyridylmethoxy) pyridazin-3 (2H) -one, 1- (2,6-difluorobenzoyl)- 3- [2-Fluoro-4- (trifluoromethyl) phenyl] urea, 1- (2,6-difluorobenzoyl) -3- [2-fluoro-4- (1,1,2,3,3,3) -Hexafluoropropoxy) phenyl] urea, 2-tert-butylimi -3-Isopropyl-5-phenyl-3,4,5,6-tetrahydro-2H-1,3,5-thiadiazon-4-one, 1- (2,6-difluorobenzoyl) -3- [2-fluoro Urea compounds such as -4- (1,1,2,2-tetrafluoroethoxy) phenyl] urea; chloronicotyl compounds such as imidacloprid, acetamiprid, nitenpyram, diacloden; cartap, buprofezin, thiocyclam, bensultap, phenoxycarb, phenazaquin , Fenpyroximate, pyridaben, liproxyfen, hydramethylnon, thiodicarb, chlorfenapyr, fenproximate, pymetrozine, pyrimidifen, tebufenozide, tebufenpyrad, triazamate, indoxacarb, sulfuramide, Examples include milbemectin, avermectin, boric acid, and paradichlorobenzene.

  Bactericides include benzimidazole compounds such as benomyl, carbendazim, thiabendazole and thiophanate methyl; phenyl carbamate compounds such as dietofencarb; dicarboximide compounds such as procimidone, iprodione and vinclozoline; diniconazole, epoxyconazole, tebuconazole, diphenoconazole , Azole compounds such as cyproconazole, flusilazole, and triadimephone; acylalanine compounds such as metalaxyl; carboxyamide compounds such as furametopil, mepronil, flutolanil, and trifluzamide; organic phosphorus such as tolcrophos methyl, fosetyl aluminum, and pyrazophos Compounds; anilinopyrimidine compounds such as pyrimesanil, mepanipyrim, and cyprodinil Cyanopyrrole compounds such as fludioxonil and fenpiclonyl; antibiotics such as blasticidin S, kasugamycin, polyoxin and validamycin; methoxyacrylate compounds such as azoxystrobin, cresoxime methyl, and SSF-126; chlorothalonil, manzeb, captan, and ford PET, Oxin copper, Basic copper chloride, Tricyclazole, Pyroxylone, Probenazole, Fusaride, Simoxanyl, Dimethomorph, CGA245704, Famoxadone, Oxolinic acid, Fluazinam, Ferimzone, Cloventazone, Isovaradione, Tetrachloroisophthalonitrile, Thiophthalimidooxybis Phenoxyarsine, 3-iodo-2-propylbutyl carbamate, silver zeolite, silica gel Silver, zirconium silver phosphate, para-hydroxybenzoic acid esters, sodium dehydroacetate, and the like potassium sorbate.

  Herbicides include triazine compounds such as atrazine and metribudine; urea compounds such as fluometuron and isoproturon; hydroxybenzonitrile compounds such as bromoxynyl and ioxynil; 2,6-dinitroaniline compounds such as pendimesalin and trifluralin Compound; Allyloxyalkanoic acid compounds such as 2,4-D, dicamba, fluroxypyr, and mecoprop; Sulfonyl urea compounds such as bensulfuron methyl, methylsulfuron methyl, nicosulfuron, primsulfuron methyl, and cyclosulfamuron; Imazapyr , Imidazolinone compounds such as imazaquin and imazetapyr; Bispyribac Na salt, Bisthiobac Na salt, Acifluorfen Na salt, Sulfentrazone, Paraquat, Flumetula , Triflusulfuron methyl, phenoxaprop-p-ethyl, cihalohop butyl, diflufenican, norflurazon, isoxaflutol, glufosinate ammunium salt, glyphosate, bentazone, beniocarb, mefenacet, propanil, fluthiamide, etc. Can be mentioned.

  Examples of plant growth regulators include maleic hydrazide, chlormecat, etephone, gibberellin, mepicut chloride, thidaziuron, inavenfide, paclobutrazol, uniconazole and the like. Insect repellents include 1S, 3R, 4R, 6R-caran-3,4-diol, dipropyl 2,5-pyridinedicarboxylate and the like.

As sterilizing fungicides, antiseptics or anti-algae agents, quaternary ammonium salt compounds such as didecyldimethylammonium chloride (DDAC), didecyldimethylammonium adipate (DDAA), polyhexamethylene biguanide (PHMB), gluconic acid Biguanide compounds such as chlorhexidine, pyridinium compounds such as cetylpyridinium chloride and dodecylpyridinium chloride, organic iodine compounds such as 3-iodo-2-propynyl-butylcarbamate, 2,3,5,6-tetrachloro- Pyridine compounds such as 4- (methylsulfonyl) pyridine, pyrithion compounds such as zinc pyrithione and sodium pyrithione, benzothiazole compounds such as 2- (4-thiocyanomethylthio) benzothiazole, Imidazole compounds such as lu-2-benzimidazole carbamate, 2- (4-thiazolyl) -benzimidazole, thiocarbamate compounds such as tetramethylthiuram disulfide, 2,4,5,6-tetrachloroisophthalonitrile, etc. Nitrile compounds, haloalkylthio compounds such as N- (fluorodichloromethylthio) -phthalimide, N- (fluorodichloromethylthio) -N, N′-dimethyl-N-phenyl-sulfamide, α-t-butyl-α (p -Chlorophenylethyl) -1H-1,2,4-triazole-1-ethanol (common name: tebuconazole) and other triazole compounds, 3- (3,4-dichlorophenyl) -1,1-dimethylurea (common name: DCMU) Phenylurea compounds such as It is done.
These physiologically active substances can be used singly or in combination of two or more.
Of these physiologically active substances, triazine compounds and / or isothiazoline compounds are preferred.

  A preferred embodiment of the composition of the present invention contains a triazine compound, an isothiazoline compound, an alkylsulfosuccinic acid surfactant, an alkylphenyl ether surfactant, and a polyoxyethylene sorbitan fatty acid ester surfactant. is there.

  The triazine compound used in the present invention is a compound having a triazine skeleton structure. As the triazine-based compound, those having an antialgal property are preferably used. Specific examples include 2-methylthio-4-t-butylamino-6-cyclopropylamino-s-triazine (also known as sibutrin), 2-methylthio-4-t-butylamino-6-ethylamino-s-triazine. (Alias: terbutrin), 2-chloro-4,6-diethylamino-s-triazine (alias: simazine), 2-chloro-4-ethylamino-6-isopropylamino-s-triazine (alias: atrazine), 2- And methylthio-4-ethylamino-6- (1,2-dimethylpropylamino) -s-triazine (also known as dimetamethrin). These can be used alone or in combination of two or more. Of these, sibutrin is preferred.

The isothiazoline-based compound used in the present invention is a compound having an isothiazoline skeleton structure. As the isothiazoline compound, those having antifungal properties are preferably used. Specific examples include 2-n-octyl-4-isothiazolin-3-one (hereinafter sometimes abbreviated as “OIT”), 5-chloro-2-methyl-4-isothiazolin-3-one, 5 -Chloro-2-n-octyl-4-isothiazolin-3-one, 4-chloro-2-n-octyl-4-isothiazolin-3-one, 4,5-dichloro-2-n-octyl-4-isothiazoline -3-one is mentioned. These can be used alone or in combination of two or more. Of these, OIT is preferred.
The amount of the isothiazoline compound is preferably more than 0 parts by mass and less than 1 part by mass, more preferably 0.3 parts by mass or more and 0.9 parts by mass or less with respect to 1 part by mass of the triazine compound. .

  In the composition according to the present invention, the total amount of the alkylsulfosuccinic acid surfactant, the alkylphenyl ether surfactant, and the polyoxyethylene sorbitan fatty acid ester surfactant is 1 part by mass of the triazine compound. Preferably they are more than 0.1 mass part and 1 mass part or less, More preferably, they are 0.2 mass part or more and 0.6 mass part or less.

  The composition according to the present invention may further contain other components. Examples of other components include organic solvents, thickeners, antioxidants, light stabilizers, fragrances, and antifoaming agents.

  Organic solvents include lower alcohols such as ethanol and isopropanol; glycol solvents such as ethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol and glycerin; ketone solvents such as acetone, methyl ethyl ketone and propylene carbonate; dimethylformamide and dimethyl sulfoxide And polar solvents such as acetonitrile and N-methylpyrrolidone.

Examples of the thickener include carboxymethyl cellulose and xanthan gum.
Examples of the antioxidant include 2,6-di-t-butyl-4-methylphenol, 2,2′-methylenebis [4-methyl-6-t-butylphenol], alkyldiphenylamine, and the like.
Examples of the light stabilizer include bis (2,2,6,6-tetramethyl-4-sebacate).

The composition of the present invention is not particularly limited by the production method. The composition of the present invention includes, for example, physiologically active substances such as triazine compounds and / or isothiazoline compounds, alkylsulfosuccinic acid surfactants, alkylphenyl ether surfactants, and polyoxyethylene sorbitan fatty acid ester compounds. It is obtained by mixing the surfactant in random order. Further, an alkylsulfosuccinic acid surfactant, an alkylphenyl ether surfactant, and a polyoxyethylene sorbitan fatty acid ester surfactant are mixed in random order to obtain a surfactant composition. It can be obtained by mixing the composition and a physiologically active substance such as a triazine compound and / or an isothiazoline compound in random order.
The above components can be dissolved or suspended in a solvent. As the solvent, those consisting only of water are preferred. Examples of water used in the composition of the present invention include tap water, purified water, ion exchange water, and distilled water. Of these, purified water or ion-exchanged water is preferred from the viewpoint of stability and economy. The composition of the present invention produced by the above method is preferably filtered to remove foreign substances.

  The composition of the present invention can be used as a medicine, agricultural chemical, health enhancer or the like as it is or as a preparation. Examples of the form of the preparation include powders, granules, pastes, microcapsules and the like. In formulation, for example, the composition of the present invention can be adsorbed on clay, talc, silica, alumina, montmorillonite and the like.

  The composition of the present invention can be applied to water-based emulsion paints, solvent-type paints, adhesives, leather, plastic products such as vinyl chloride, water used in the paper pulp process, industrial cooling water, etc. It is useful as an agate and algae control agent. Of these, the composition of the present invention is suitable for paints.

The paint can be obtained by blending the composition of the present invention in a paint composition.
Examples of the coating composition include a coating composition containing an aqueous resin, a coating composition containing an organic solvent-dispersible resin, and a coating composition containing a wax.

The resin used in the coating composition can be appropriately selected in consideration of durability, water resistance, adhesiveness, heat resistance, blocking resistance, flexibility, and the like. The resin is preferably an aqueous resin. The aqueous resin is a resin that can be dissolved or emulsified and dispersed in water.
Resins are roughly classified into rubbery polymers and resinous polymers.
Examples of the rubbery polymer include natural rubber, ethylene-propylene-diene rubber (EPDM), styrene-butadiene rubber (SBR), chloroprene rubber (CR), acrylonitrile-butadiene rubber (NBR), and the like.
Examples of the resinous polymer include natural resins such as pine resin, polyethylene, styrene-butadiene resin, polyvinyl acetate, ethylene-vinyl acetate copolymer, polyvinyl chloride, polyvinyl butyral, polystyrene, styrene-butadiene resin. , Urethane resin, silicon resin, acrylic resin and the like.

The composition of the present invention can be applied to materials that require effects such as antialgae and antifungal properties. Examples of the material include fibers, sanitary processed products, medical molded products, detergents, cosmetics, foods, fruits and vegetables, seeds, agricultural products, livestock, clean films, packaging materials, bactericidal materials, paints, emulsion resins, cutting oils. Metal processing oil such as plywood, wood, casein, starch paste, glue, coated paper, paper coating liquid, surface sizing agent, adhesive, synthetic rubber latex, printing ink, polyvinyl alcohol film, vinyl chloride film, plastic Examples include products, cement admixtures, sealing agents, and joint preparations. It can also be used for various industrial waters used in paper pulp mills and cooling water circulation processes.
The application method can be appropriately selected depending on the target material. For example, a method of mixing with a material, a method of soaking in a material, a method of applying to the surface of the material, and the like can be mentioned.

  Next, an Example is shown and this invention is demonstrated more concretely. However, the present invention is not limited to these examples.

Example 1
In a beaker, 864.8 parts by mass of water was added, and while stirring this, New Calgen CP15-200 (registered trademark, manufactured by Takemoto Yushi Co., Ltd., POA alkylphenyl ether) 8.57 parts by mass, Pionein D-945-T Registered trademark, Takemoto Yushi Co., Ltd., POE sorbitan trioleate) 8.57 parts by mass, Aerol CT-1L (registered trademark, manufactured by Toho Chemical Industry Co., Ltd., sodium dioctyl sulfosuccinate) 4.09 parts by mass, New Calgen PS- 5 parts by mass of LH (registered trademark, Takemoto Yushi Co., Naphthalenesulfonic acid formaldehyde condensate sodium salt), 1 part by mass of Surfinol 104 (registered trademark, manufactured by Air Products, acetylene-based antifoaming agent), and Rhodopol G (registered) Trademark, Rhodia Nikka Co., Ltd., xanthan gum) 4.2 parts by mass was added to obtain a suspension. To this suspension, 63.0 parts by mass of sibutrin (DP-2159, manufactured by Nippon Soda Co., Ltd.) and 42.0 parts by mass of OIT (KATHON 893T, manufactured by Dow) were added and dispersed. The dispersion was pulverized using a dyno mill (Shinmaru Enterprises Co., Ltd., horizontal bead mill: 0.3 L continuous mill) under the conditions of a peripheral speed of 12 m / sec and a flow rate of 100 g / min. A was obtained.

Comparative Example 1
Into a beaker, 906.8 parts by mass of water was added, and while stirring this, 8.57 parts by mass of Neukalgen CP15-200, 8.57 parts by mass of Pione D-945-T, 4.09 parts by mass of Airroll CT-1L , 5 parts by weight of Neukalgen PS-LH, 1 part by weight of Surfinol 104, and 4.2 parts by weight of Rhodopol G were added to obtain a suspension. To this suspension, 63.0 parts by mass of sibutrin (DP-2159, manufactured by Nippon Soda Co., Ltd.) was added and dispersed. The dispersion was pulverized using a dyno mill under conditions of a peripheral speed of 12 m / sec and a flow rate of 100 g / min to obtain an aqueous suspension preparation B.

Comparative Example 2
Into a beaker, 906.8 parts by mass of water was added, and while stirring this, 8.57 parts by mass of Neukalgen CP15-200, 8.57 parts by mass of Pione D-945-T, 4.09 parts by mass of Airroll CT-1L , 5 parts by weight of Neukalgen PS-LH, 1 part by weight of Surfinol 104, and 4.2 parts by weight of Rhodopol G were added to obtain a suspension. To this suspension, 63.0 parts by mass of terbutrin (manufactured by McTesim Agan) was added and dispersed. The dispersion was pulverized using a dyno mill under conditions of a peripheral speed of 12 m / sec and a flow rate of 100 g / min to obtain an aqueous suspension formulation C.

(Stability test)
Five bottles each containing 1 kg of the aqueous suspension preparation were prepared. One was allowed to stand under the following conditions.
(1) 1 month at -5 ° C (2) 1 month at room temperature (3) 1 month at 40 ° C (4) 1 month at 60 ° C (5) 50 ° C and -15 ° C every 72 hours 1 month after switching to

The state in the bottle after standing was visually observed.
The aqueous suspension preparation A did not show any changes such as precipitation or floating water under any conditions.
On the other hand, in the aqueous suspension preparation B and the aqueous suspension preparation C, floating water was observed under all conditions. Moreover, the sediment which condensed on the bottle bottom part was observed.

  The volume-based particle size distribution was measured for the sample of condition (1). The results are shown in FIGS.

In the aqueous suspension B and the aqueous suspension C, a clear frequency peak is observed at a particle diameter of 20 μm to 40 μm, and it can be seen that particle growth occurs due to low temperature storage.
On the other hand, it can be seen that the aqueous suspension A according to the present invention has a narrow particle size distribution, and no particle growth occurs even when stored at a low temperature.

Claims (14)

  A composition comprising a triazine compound, an isothiazoline compound, an alkylsulfosuccinic acid surfactant, an alkylphenyl ether surfactant, and a polyoxyethylene sorbitan fatty acid ester surfactant.   The composition according to claim 1, wherein the amount of the isothiazoline-based compound is more than 0 parts by mass and less than 1 part by mass with respect to 1 part by mass of the triazine-based compound.   The total amount of the alkylsulfosuccinic acid surfactant, the alkylphenyl ether surfactant, and the polyoxyethylene sorbitan fatty acid ester surfactant is more than 0.1 parts by weight with respect to 1 part by weight of the triazine compound, and The composition of Claim 1 or 2 which is 1 mass part or less.   Triazine compounds are 2-methylthio-4-t-butylamino-6-cyclopropylamino-s-triazine, 2-methylthio-4-t-butylamino-6-ethylamino-s-triazine, 2-chloro- 4,6-diethylamino-s-triazine, 2-chloro-4-ethylamino-6-isopropylamino-s-triazine, and 2-methylthio-4-ethylamino-6- (1,2-dimethylpropylamino)- The composition according to any one of claims 1 to 3, which is at least one selected from the group consisting of s-triazines.   The isothiazoline-based compounds are 2-n-octyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, 5-chloro-2-n-octyl-4-isothiazoline-3 -One, 4-chloro-2-n-octyl-4-isothiazolin-3-one, and at least one selected from the group consisting of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one The composition according to any one of claims 1 to 4, wherein   The composition according to any one of claims 1 to 5, wherein the composition is an anti-algal and anti-fungal composition.   A composition comprising an alkylsulfosuccinic acid surfactant, an alkylphenyl ether surfactant, and a polyoxyethylene sorbitan fatty acid ester surfactant.   A composition comprising a physiologically active substance, an alkylsulfosuccinic acid surfactant, an alkylphenyl ether surfactant, and a polyoxyethylene sorbitan fatty acid ester surfactant.   Furthermore, it is a composition containing a solvent, Comprising: This composition consists only of water.   The composition according to claim 8 or 9, wherein the physiologically active substance is a water-insoluble compound.   The composition according to any one of claims 8 to 10, wherein the physiologically active substance is either a triazine compound or an isothiazoline compound.   The composition according to any one of claims 1 to 11, wherein the alkylphenyl ether surfactant is 1 part by mass or more and 5 parts by mass or less with respect to 1 part by mass of the alkylsulfosuccinic acid surfactant.   The polyoxyethylene sorbitan fatty acid ester surfactant is 1 part by mass or more and 5 parts by mass or less with respect to 1 part by mass of the alkylsulfosuccinic acid surfactant. 13. Composition.   The coating material containing the composition of any one of Claims 1-13.

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