JP2011194213A - Therapeutic material for skin diseases caused by trichophyton bacteria and therapeutic device for the diseases - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a revolutionary therapeutic material for skin diseases caused by Trichophyton bacteria making an effective anti-trichophyton bacteria component with excellent anti-bacterial (sterilizing) effect against Trichophyton bacteria act on all trichophyton bacteria existing on from the surface to the inside of the skin to sterilize trichophyton bacteria, the etiologic bacteria, from the origin to make complete recovery from skin diseases caused by trichophyton bacteria, and a therapeutic device therefor.SOLUTION: The therapeutic material for skin diseases caused by trichophyton bacteria includes an anti-trichophyton effective component generation portion 2 having an anti-trichophyton effective component generation agent 1 containing the anti-trichophyton effective component in a gas state presenting antibacterial and sterilizing actions against trichophyton bacteria or making the anti-trichophyton effective component into a gas state and discharging it. The gas state anti-trichophyton effective component is discharged from the anti-trichophyton effective component generation portion 2 and the discharged gas state anti-trichophyton effective component is attached to and penetrate into a lesion part.

Description

  INDUSTRIAL APPLICABILITY The present invention relates to ringworm used for the treatment of skin diseases caused by ringworm fungus having an antifungal active ingredient having an antibacterial (bactericidal) effect against ringworm fungus (also referred to as filamentous fungus) which is a causative bacterium such as athlete's foot and bug. The present invention relates to a skin disease treatment material and a treatment tool thereof.

  At present, it is said that about 15% of Japanese people, that is, one out of every six people suffer from skin diseases caused by ringworm fungus (so-called athlete's foot).

  As shown in FIG. 17, the epidermis of human skin has a crevice (concave portion) and a skin hill (convex portion), and is a type of fungus that is a causative fungus causing ringworm (also called a filamentous fungus). ) Mainly occurs in the crevice, which is a recess.

  The epidermis of human skin, that is, the stratum corneum, has a mechanism in which cuticles are secreted to prevent dryness of the epidermis, and the components of this cuticle are keratin containing proteins. Mold accumulates in the groove, mixes with waste excretion discharged from sweat glands, and rots due to moisture to germinate mold. Molds that develop in the skin groove are ringworm fungus, and this ringworm grows and grows in the skin groove using keratin as a nutrient source, thereby expanding the affected area, that is, the symptoms of skin disease caused by ringworm bacteria. go.

  In addition, this ringworm is branched and proliferated. It seeks keratin as a nutrient source in the deep part of the stratum corneum, sinks into the skin cells (in the stratum corneum), and separates from the branches to newly proliferate. It is a fungus that has mitochondria, an organelle unique to eukaryotic cells, and has various characteristics. Antibacterial (sterilizing) ringworms with such characteristics. That is, it was very difficult to completely cure the skin disease caused by the ringworm fungus factor.

  In order to cope with the current situation in which complete cure is difficult and the number of patients is increasing year by year, approximately 70 kinds of athlete's foot treatment drugs are provided by pharmaceutical manufacturers in Japan alone. However, conventional athlete's foot treatment seems to be effective as soon as it is treated, suppressing itching, and in fact, it has little effect as an athlete's foot treatment, and treatment seems to be completely cured. There are many problems such as recurrence as soon as it is stopped, and worsening of symptoms in some people, and there are few athlete's foot treatments that satisfy patients suffering from athlete's foot (dermatosis caused by ringworm fungus) It is a situation that can be said.

  Further, the problems of this conventional athlete's foot treatment drug will be described in detail. Most of the conventional commercially available athlete's foot treatment drugs are water-soluble, ointment (cream) or powder spray type. These are applied directly to human skin to cause the antifungal (bactericidal) effect of the athlete's foot therapeutic agent to act on the skin surface or the causal fungus that is a causative bacterium in the skin.

  However, in this ointment (cream form) or liquid form, the therapeutic agent containing the anti-tinea fungi active ingredient has a large particle size and is difficult to penetrate into the skin cells.

  In addition to this, conventional athlete's foot treatments are applied to the skin by applying an ointment that rubs strongly into the affected area, or by applying a liquid that has a low temperature at which the skin feels cold. Although human skin cells will give strong stimuli, human skin cells react sensitively to environmental stimuli such as strong force, temperature, and light from the outside, and have a defensive action to prevent the entry of foreign substances from the outside. Since the skin breathing hole contracts, the skin breathing hole, which is the entrance to the skin cell inside, is contracted by the stimulation at the time of application. As a result, the particles containing the active ingredients of the anthracnose antifungal agent applied to the affected area are prevented from penetrating into the skin cells, and the skin cells (specifically, Horn Since the active ingredient of anti- ringworm fungus does not reach the ringworm that exists in the deep part of the layer, as a result, only the epidermis of the affected part (surface layer of the stratum corneum) is treated, so that it seems to be completely cured There were many patients who relapsed immediately after stopping treatment and thus continued to be incomplete.

  Also, in general, skin disease caused by ringworm fungus, that is, the area where athlete's foot develops, has many toes, and the toes are poorly breathable in terms of environment and shape, and moisture accumulates due to sweat. Because it is easy, it is in a situation of promoting the growth of ringworm.

  Furthermore, most commercially available athlete's foot treatments are applied directly to the affected area with an ointment or a liquid form, and depending on the substances contained in the athlete's foot treatment and the substances that reduce the breathability, it is even more effective. The increase in the humidity of the affected area and further promotion of the growth of ringworm bacteria was one of the factors that hindered the complete cure of athlete's foot treatment.

  In other words, by leaving the residual component of the athlete's foot drug attached to the skin of the affected area, the waste product excreted from the skin is inhibited, and a film of this waste product is formed on the surface of the affected area to respire the skin. Will further exacerbate the symptoms because it will prevent the heat and moisture released from the skin from spreading to the outside and create an environment that promotes the growth of ringworm bacteria present in the affected area. It was.

  By the way, there are three points to completely cure the skin diseases (such as athlete's foot and bugs) caused by ringworm fungus. The first point is to always improve the ventilation of the affected area. Is to continue the treatment for a long time while living a normal life, and the third point is that it can be treated without being noticed by others.

  For this purpose, athlete's foot treatment needs to focus not only on the therapeutic material (therapeutic agent) but also on the fixing device for fixing the therapeutic material (therapeutic agent). It was difficult to completely cure skin diseases caused by ringworm fungus unless they were identified.

  Therefore, the present invention acts against all ringworms present in the skin from the surface layer with an antifungal active ingredient having an excellent antibacterial (bactericidal) effect against ringworm, and It can be cut off from the beginning, moreover, the point to cure the above-mentioned skin disease caused by ringworm fungus can be easily carried out, and can be satisfied and used by people suffering from skin disease caused by ringworm. It is an object of the present invention to provide an epoch-making therapeutic agent for dermatosis caused by tinea factor which can surely cure the dermatosis of the cause, and a treatment tool therefor.

  An anti- ringworm fungus active ingredient that contains an anti-tinea fungus active ingredient that gives antibacterial and bactericidal action against ringworm, a causative agent of athlete's foot and insects, in a gaseous state or that can be released in the form of a gas An anti- ringworm fungus active ingredient generator 2 having a generating agent 1, releases the gaseous anti-tinea fungus active ingredient from the anti-tinea fungus active ingredient generator 2, and releases the released gaseous anti-tinea fungus active ingredient The present invention relates to a therapeutic agent for skin diseases caused by ringworm fungi, characterized in that it can be attached and penetrated into the affected area.

  The anti-tinea bacterium active ingredient generating part 2 containing the anti-tinea dermatitis active ingredient in a gaseous state is made of a fiber, and relates to a dermatosis-causing agent for tinea fungus factor according to claim 1. .

  Also, the anti-tinea active ingredient generator 2 having the anti-tinea active ingredient generator 1 is configured to allow the gaseous anti-tinea active ingredient generated from the anti-tinea active ingredient generator 1 to be freely breathable. The present invention relates to a material for treating skin diseases caused by ringworm fungus according to claim 1.

  Further, the anti-tinea bacterium active ingredient generator 1 is formed into a granular shape, and the anti-tinea bacterium active ingredient generator 2 having the granular anti-tinea bacterium active ingredient generator 1 generates the granular anti-tinea bacterium active ingredient generator. The agent 1 is configured to be movably accommodated, and the gaseous anti-tinea fungus active ingredient generated from the anti-tinea bacterium active ingredient generator 1 accommodated movably is used as the anti-tinea bacterium active ingredient generator 2. 4. The skin disease treatment material for ringworm fungus factor according to any one of claims 1 and 3, wherein a vent hole 3 is provided to be discharged outward.

  The anti-tinea bacterium active ingredient is a pyridine alkaloid, and relates to the dermatosis-causing agent for dermatophytosis according to any one of claims 1 to 4.

  Further, the pyridine alkaloid is trigonene, piperine, lobeline, pseudoperetierin, coniine, calpain, execetin, nornicotine, nicotine, α-nicotyrin, β-nicotyrin, nicotinic acid, nicotinonitrile, arekaidin, arecoline, anabasine, It is selected from ricinin and lithinin, according to the skin disease treatment material for ringworm fungus factor according to claim 5.

Further, an alkaloid compound composed of carbon, hydrogen, and nitrogen and having a molecular formula represented by C _x H _y N ₂ is used as an anti- ringworm fungus active ingredient, and the alkaloid compound that is the anti-tinea fungus active ingredient is in a gaseous state, The present invention relates to a therapeutic agent for dermatosis caused by ringworm fungus, characterized in that the active ingredient generating portion 2 containing antibacterial fungus containing the gaseous alkaloid compound can be attached to the affected area.

  The material for treating dermatosis caused by ringworm fungus according to claim 7, wherein the alkaloid compound which is an active ingredient of anti-ringworm fungus is selected from nicotine, nicotinonitrile, α-nicotiline, and β-nicotiline. It is related to.

  In addition, the anti-tinea fungus active ingredient generator 2 has a content of the alkaloid compound of 0.8 mg to 1.2 mg. It relates to the skin disease treatment material of the factor.

  Furthermore, the anti-tinea fungi active ingredient generator 2 has a moisture content of 20% or less, and relates to a dermatosis-causing agent for tinea fungus factor according to any one of claims 7 to 9, Is.

  The anti-tinea bacterium active ingredient generator 2 is made of fiber, and the anti-tinea bacterium active ingredient generator 2 made of this fiber is formed in a roll shape to form a roll-like sheet. The structure according to any one of claims 7 to 10, wherein the part 2 can be attached between fingers.

  The dermatosis-treating material for ringworm fungus factor according to any one of claims 1 to 11, and the treatment material for pressing the dermatosis treatment material for ringworm fungus factor attached between the toes, which is an affected part. It is a skin disease treatment tool for ringworm fungus factor comprising a presser 4, wherein the therapeutic material presser 4 is made of a material having air permeability, and each finger of a foot is inserted into one end side. Provided with a locking portion 6 that is locked to the heel or ankle at the other end side, and a pressing portion that presses against the dermatosis-causing agent for causing ringworm fungus is provided between the finger insertion portions 5. The present invention relates to a device for treating skin diseases caused by ringworm fungus, which is characterized by having a constitution.

  Since the present invention is constituted as described above, the gaseous anti-tinea active ingredient penetrates into the skin cells of the affected area, that is, into the deep layer of the stratum corneum. Unprecedented breakthrough ringworm-causing dermatosis that can be cut off (killed), and can cure the dermatosis-causing dermatosis that has been required to be treated for a long time. It becomes a therapeutic material.

  That is, most of the conventional skin disease treatment materials (so-called athlete's foot treatment drugs) caused by ringworm fungi are aqueous solutions, ointments (cream form) or powder mist spray type, and these treatments contain anti-tinea fungus active ingredients. Since the drug is present in a relatively large particle size, it is difficult to penetrate into the skin cells. As a result, the antibacterial (bactericidal) action is only exerted on ringworm bacteria present on the skin surface, and the inside of the skin cells, that is, the stratum corneum Since the ringworm in the deep part of the skin continues to exist without being sterilized, the disappearance of the ringworm on the skin epidermis only temporarily subsides the symptoms, and the ringworm in the deep part of the stratum corneum repeats branch growth. Since it spreads to the surface of the skin again, symptoms such as itching and pain recur, and it was supposed to suffer from athlete's foot without being completely cured forever. Small granules By being in a state, it can easily penetrate into the skin cells, that is, the deep part of the stratum corneum, and not only to the ringworms present on the skin surface but also to the ringworms present in the deep part of the stratum corneum. The antibacterial (bactericidal) effect also acts on it, and can kill the ringworm bacteria completely from the beginning.

  Moreover, it is applied without irritating the skin without applying it so that it rubs strongly into the affected area like an ointment, or applying something that is cold like a liquid therapeutic agent. The skin breathing hole contracts and the entrance for the active ingredient of anti-tinea fungus to penetrate into the skin cells is not narrowed, and it is always easy to penetrate inside the skin cells, ensuring that the stratum corneum It is an epoch-making therapeutic agent for dermatosis caused by trichophyton, which exhibits an excellent therapeutic effect capable of reaching the active ingredient of anti- ringworm bacteria to the ringworm bacteria present in the deep part of the skin.

  Further, in the inventions according to claims 2 to 4, it becomes a therapeutic agent for skin diseases caused by ringworm bacteria, which can release a gaseous anti-ringworm active ingredient more easily.

  Moreover, in invention of Claims 5-8, it becomes the dermatological treatment material of the groundbreaking fungus factor which has the therapeutic effect and was excellent in practicality.

  The invention according to claim 9 provides a skin disease treatment material for ringworm fungus that has no adverse effects on the human body, has a therapeutic effect, and has no safety problems.

  In the invention according to claim 10, it is possible to keep the moisture in the anaerobic living environment of ringworm bacteria, and to become a skin disease treatment material of ringworm bacteria factors that can further enhance the effect of the therapeutic agent.

  In the invention of claim 11, the contact area with the affected part can be further increased. For example, it can be reliably applied to a three-dimensional affected part such as between the toes (the root and the inner sides of the fingers on both sides). It is an epoch-making material for treating skin diseases caused by trichophyton, which can be attached to a therapeutic agent and can kill trichophyton.

  In the invention described in claim 12, when the skin disease treatment material caused by ringworm fungus is attached to the affected area, the skin disease treatment material caused by ringworm fungus is surely pressed against the affected area and the attached state is maintained. Because the skin disease treatment material caused by ringworm bacteria does not deviate from or deviate from the affected area, the active ingredient of anti-ringworm bacteria can continuously adhere to the affected area and exhibit an excellent therapeutic effect. It becomes a dermatosis treatment tool of various ringworm fungus factors.

FIG. 3 is an explanatory perspective view in which a part showing the athlete's foot treatment material of Example 1 is cut away. It is explanatory drawing which shows a mode that the anti- ringworm fungus active ingredient discharge | released from the anti-ringworm fungus active ingredient generation | occurrence | production part of Example 1 permeates into a skin cell through an envelope. It is a top view which shows the state which contact | attached the athlete's foot treatment material of Example 1 between toes. It is AA sectional drawing of FIG. It is a top view which shows the athlete's foot therapeutic material at the time of comprising the anti- ringworm fungus active ingredient generation | occurrence | production part of Example 1 in a capsule storage body. It is a description perspective view which shows the athlete's foot treatment material at the time of comprising the anti- ringworm fungus active ingredient generation | occurrence | production part of Example 1 in a capsule-shaped storage body. It is a description exploded perspective view which shows the athlete's foot treatment material at the time of comprising the anti- ringworm fungus active ingredient generation | occurrence | production part of Example 1 and Example 2 in a roll-shaped sheet | seat, and providing in an adhesive sheet and comprising the adhesive bandage type. It is a disassembled perspective view which shows the athlete's foot treatment material at the time of comprising the anti-tinea fungus active ingredient generation | occurrence | production part of Example 1 and Example 2 in a roll-shaped sheet | seat, providing in an adhesive sheet, and comprising the adhesive bandage type. It is a description perspective view which shows the athlete's foot treatment material at the time of comprising the anti- ringworm fungus active ingredient generation | occurrence | production part of Example 1 and Example 2 in a roll-shaped sheet | seat, providing in an adhesive sheet, and comprising the adhesive bandage type. It is a side view which shows the athlete's foot treatment material at the time of comprising the anti-tinea fungus active ingredient generation | occurrence | production part of Example 1 and Example 2 in a roll-shaped sheet | seat, providing in an adhesive sheet, and comprising in a bandage type. It is explanatory drawing which shows the use condition of the athlete's foot treatment material of Example 1 and Example 2. FIG. It is explanatory side view which shows the use condition of the athlete's foot treatment material of Example 1 and Example 2. FIG. It is a perspective view which shows the treatment material pressing tool of Example 1 and Example 2. FIG. It is explanatory side view which shows the use condition of the treatment material pressing tool of Example 1 and Example 2. FIG. It is a description perspective view which shows the use condition of the treatment material pressing tool of Example 1 and Example 2. FIG. It is explanatory drawing which shows a mode that the gaseous anti- ringworm fungus active ingredient contained in the anti- ringworm fungus active ingredient generation | occurrence | production part of Example 1 and Example 2 reaches | attains the deep layer part of a stratum corneum. It is explanatory drawing which shows the state of a human epidermis.

  An embodiment of the present invention which is considered to be suitable will be briefly described with reference to the drawings showing the operation of the present invention.

  Anti-tinea bacterium active ingredient generator 2 containing gaseous anti-tinea bacterium active ingredient or anti-tinea bacterium active ingredient generator 2 having anti-tinea bacterium active ingredient generator 1 that releases gaseous anti-tinea bacterium active ingredient Gaseous anti-tinea active ingredient, such as pyridine alkaloids, is released from this, and the released anti-tinea active ingredient is attracted to and attached to the affected area (skin surface) that develops the skin disease caused by trichomycosis. By the antibacterial (bactericidal) action of the active ingredient of anti- ringworm bacteria attached to the skin surface, the ringworm bacteria existing on the skin surface are sterilized.

  In addition, the active ingredient of anti-tinea fungus adhering to the skin surface further penetrates into the skin cells, that is, the deep part of the stratum corneum by skin respiration, and this infiltrated anti-tinea fungus is effective. The ingredient also acts against ringworm fungi present in the deep part of the stratum corneum and sterilizes.

  More specifically, the therapeutic agent for dermatosis caused by ringworm fungus of the present invention has an anti-tinea bacterium active ingredient present in a very fine particle state (particle size: about 0.1 μm to 0.5 μm) in a gaseous state. Yes. In general, gaseous substances are very light and have a very small particle size, and have the property of being attracted by water molecules having a large mass, and this moisture is also present on the human skin surface.

  That is, the present invention makes use of the properties of the gaseous substances described above to easily attract and attach the gaseous anti-tinea active ingredient released from the anti-tinea active ingredient generating unit 2 to the human skin surface. Can do.

  The active ingredient of anti- ringworm fungus that adheres to the skin surface is not only the ringworm fungus that exists on the skin surface, but also the ointment (cream-like) and powder mist spray type athlete's foot athletes have a therapeutic agent particle size. The stratum corneum easily penetrates into the skin cells by the skin respiration action from the fine skin breathing holes formed in the skin cells, even against ringworm bacteria that exist in the deep part of the stratum corneum that could not be reached due to its large size Since it can reach the deeper part of the body, it can cut off the source of branching proliferative ringworm, so it will recur immediately as soon as the symptoms subside as before, and this can be repeated for a long time Unlike the treatment of dermatosis caused by ringworm fungus, it is a highly effective therapeutic agent for skin disease caused by tinea fungus that can cure skin disease caused by ringworm in a short period of time. .

  In addition, for example, when pyridine alkaloid (for example, execetin or nicotine) is used as an active ingredient for anti-tinea, this pyridine alkaloid is a substance having a strong hygroscopic and antibacterial (bactericidal) effect. By drying the affected area, it is possible to eliminate moisture, which is one of the survival conditions for ringworm, to make an anaerobic living environment for ringworm, and to kill and decompose the ringworm reliably by antibacterial (bactericidal) effect.

  Furthermore, there is almost no irritation compared to conventional ointment (cream) and powder mist spray type athlete's foot treatment drugs, and the above-mentioned defense action against skin irritation does not work, so that skin cells contract and resist Since the skin respiratory pore that becomes the entrance to the inside of the skin cells of the active agent for ringworm fungus is not narrowed, the gaseous anti-ringworm fungus active component released from the active portion for active ingredient of anti-ringworm fungus 2 is continuously produced by skin respiration. It penetrates into the skin cell layer and reaches the ringworm that exists in the deep part of the stratum corneum, and it is surely killed by the above-mentioned strong moisture absorption and bactericidal power. The groundbreaking ringworm that can treat and cure the skin diseases (such as athlete's foot and bugs) of this ringworm that could not be completely cured. Factor skin disease treatment The wood.

  A first embodiment of the present invention will be described with reference to the drawings.

  This embodiment is a skin disease treatment material caused by ringworm fungus, specifically, an athlete's foot treatment material 7 for treating athlete's foot developed between the toes of the foot, and a foot finger that is an affected part of the athlete's foot treatment material 7 A skin disease treatment tool of ringworm fungus factor comprising a treatment material presser 4 for pressing the athlete's foot treatment material 7 from the outside so that the athlete's foot treatment material 7 is not displaced or detached from the affected area when it is attached between It is.

  Specifically, the athlete's foot treatment material 7 of the present embodiment includes an anti-tinea fungus active ingredient generator 2 containing a gaseous anti-tinea active ingredient and an envelope covering the anti-tinea active ingredient generator 2. More specifically, the anti-tinea fungi active ingredient generator 2 is a fiber formed in a columnar shape (roll shape), and the anti-tinea fungus active ingredient generator 2 comprising this columnar fiber. In this composition, the active ingredient of the anti-tinea fungus in the form of gas is contained, and the peripheral surface of the active ingredient-producing part 2 of the anti-tinea fungus is covered with the envelope 8 made of fibers.

  In addition, pyridine alkaloid is used as the gaseous anti-tinea active ingredient contained in the anti-tinea active ingredient generator 2, and in this embodiment, execetin, which is one of the pyridine alkaloids, is generated. The structure is contained in part 2.

  This pyridine alkaloid, execetin, is a component that is abundantly contained in horsetail, which is easily available in nature. In this example, the composition using execetin extracted (generated) from horsetail of the plant is used. It is said.

  In this example, as a method of extracting (generating) gaseous exetine from this horsetail, first, the collected horsetail is dried in the sun, the dried horsetail is crushed, and hot air is blown to the dried and crushed horsetail. This is a method for producing execetin-containing smoke, that is, gaseous execetin, by dehydrating and drying, further finely pulverizing the dehydrated and dried cedar, and burning (specifically, steaming) the crushed cedar. Adopted.

  The gaseous execetin thus produced is contained in the anti-tinea fungus active ingredient generator 2 composed of cylindrical fibers, and the anti-tinea fungus active ingredient generator 2 containing gaseous execetin is dried, The anti-tinea active ingredient generating part 2 containing this gaseous exetine is further dried, and the moisture content of the anti-tinea active ingredient generating part 2 is a predetermined value or less, specifically, 20 wt% or less, Preferably, the peripheral surface of the columnar (roll-shaped) anti-tinea fungus active ingredient generating part 2 which is adjusted to 10 wt% to 16 wt% and whose water content is adjusted to a predetermined value or less is covered with the envelope 8 made of fiber. The envelope member 8 has a configuration in which mesh-like thin sheet-like fibers are formed in a plurality of layers.

  In the present example, gaseous execetin is obtained from Sugina, a natural plant of the family Cryptaceae, but this execetin can also be produced chemically to obtain gaseous execetin. The method is not limited to the method shown in the present embodiment, and is appropriately adopted.

  In addition, as described above, the athlete's foot treatment material 7 of the present embodiment has a configuration in which the anti-tinea fungus active ingredient generating part 2 containing exetin is formed of columnar fibers. For example, instead of the columnar fibers, 5 and 6, a configuration using a capsule-like storage body may be used, or a roll-shaped sheet as shown in FIGS. 7 and 8 may be used.

  Specifically, when the anti-tinea fungus active ingredient generator 2 is configured using a capsule-like storage body, the anti-tinea fungus active ingredient generator 2 is formed in a capsule-like storage body, and this capsule-like storage body A vent hole 3 is formed in the wall of the anti-scabies fungus active ingredient generating part 2 configured in the capsule-like housing so that the inside and the outside can be freely ventilated, and the anti-scabies fungus active ingredient generated so as to be ventilated is generated. An anti-tinea bacterium active ingredient generator 1 capable of releasing an anti-tinea bacterium active ingredient in the form of gas in the part 2 is housed, and the anti-tinea bacterium active ingredient generated by the anti-tinea bacterium active ingredient generator 1 is an anti-tinea bacterium The active ingredient generator 2 is discharged to the outside.

  More specifically, the anti-tinea bacterium active ingredient generator 1 contained in the anti-tinea bacterium active ingredient generator 2 is formed into a granular shape, and can be moved freely within the capsule-shaped anti-tinea bacterium active ingredient generator 2. It is set as the structure accommodated, It is set as the structure which releases more anti- ringworm bacteria active ingredients by colliding with the anti-ringworm bacteria active ingredient generating agent 1 by moving in this anti-ringworm bacteria active ingredient generation | occurrence | production part 2. FIG.

In addition, when the anti-tinea active ingredient generating part 2 is configured as a roll sheet, the fiber formed into a sheet is made to contain a gaseous anti-tinea active ingredient and the fiber sheet containing this anti-tinea active ingredient Is formed into a roll shape to form the anti-tinea fungus active ingredient generating part 2 into a roll-like sheet, which is further dried, and the water content of the anti-tinea fungus active ingredient generating part 2 is not more than a predetermined value as described above. The both ends of the roll-shaped sheet with the moisture content adjusted are formed in an inclined state toward the lower inner side to form a reverse trapezoidal shape in side view, and this is formed at the center of the adhesive sheet 9 Established and configured as a bandage type.

  When the athlete's foot treatment material 7 configured as described above is attached to the affected area, the therapeutic material pressing tool for pressing the athlete's foot treatment material 7 from the outside so that the athlete's foot treatment material 7 is not displaced from or removed from the affected area. 4 is used.

  This therapeutic material stopper 4 is made of a material having air permeability, provided with a finger insertion part 5 for inserting each finger of a foot on one end side, and a locking part for locking to a heel or ankle on the other end side. 6 is provided, and a pressing portion that presses against the athlete's foot treatment material 7 is provided between the finger insertion portions 5.

  Specifically, an opening is provided on the distal end side of the finger insertion portion 5 to configure the finger insertion portion 5 so that the toes of the toes are exposed, and between the finger insertion portions 5, that is, between the fingers. In order to improve the air permeability from the outside to the athlete's foot treatment material 7 also from the pressing part that presses the athlete's foot treatment material 7 in contact, the entire treatment material stopper 4 is made of a mesh material.

  In addition, this mesh material employs a stretchable material such as a sock. When the therapeutic material stopper 4 is worn, the finger is passed through the finger insertion portion 5 and the locking portion 6 is attached to the heel. It is set as the structure which does not provide the coating | coated surface which coat | covers the instep and the back of the foot.

  Therefore, using a mesh material, the body temperature is less likely to stay in the affected area, that is, it is made of a material with good ventilation, and the contact area with the foot surface is minimized to the minimum possible. In particular, the inter-finger space is warmed by body temperature so that moisture does not swell.

  Further, the therapeutic material stopper 4 of the present embodiment does not press the skin with a strong force that gives irritation to the skin, but the gaseous active anti-tinea fungus active ingredient without causing the skin to defend against the irritation. Since it is pressed and locked with a pressing force that allows it to be easily penetrated into the skin cells, the active ingredients of the anti-tinea fungus adhering to the affected area are not contained in the skin cells without causing a skin defense action due to environmental stimulation. Antibacterial (sterilizing) action can be applied to ringworm bacteria that penetrate easily and exist in the deep part of the stratum corneum. In addition, the entire foot is not compressed, and a feeling of pressure is felt even when worn. First, when the treatment material stopper 4 is worn, since the wearer does not feel uncomfortable, it can be worn for a long time and can have a high therapeutic effect. It becomes a tool.

  In addition, the structure of the treatment material stopper 4 is not limited to the above, and it has good air permeability and does not overstress the affected part, and can be configured to press and lock the athlete's foot treatment material 7 attached between the toes. If it is a thing, it will employ | adopt suitably.

  The skin disease treatment tool of the ringworm fungus factor comprising the athlete's foot treatment material 7 and the treatment material retainer 4 configured as described above, or the skin disease of the ringworm fungus factor (specifically, using the athlete's foot treatment material 7) The following are some examples of treatments that have been treated.

  In addition, when only the athlete's foot treatment material 7 is used, a fixing tool (for example, a bandage) other than the treatment material stopper 4 for fixing and holding the athlete's foot treatment material 7 on the affected part is used. In addition, under the circumstances where the commercially available therapeutic drugs for athlete's foot were not completely cured, the effect of the skin disease treatment device for the cause of ringworm of this Example was confirmed.

<Treatment example 1>
・ Blister-type athlete's foot female 62 years old Medical history 2-3 years Symptoms: A blister developed between the fingers of both hands, and itching and reddish.

  Treatment result: The athlete's foot treatment material 7 was applied between the fingers of the affected area, fixed with a bandage, and the athlete's foot treatment material 7 was replaced every time the bath was taken.

<Treatment example 2>
-Intercostal athlete's foot male Male 43 years of medical history Over 10 years Symptoms: Athlete's foot develops between the toes of both feet, the skin is white and very soft and itchy. Itching was particularly intense from spring to summer, and over-the-counter drugs were used, but there was no effect at all.

  Treatment result: The athlete's foot treatment material 7 is sandwiched between the fingers of the affected part, the therapeutic material pressing tool 4 is attached so that the athlete's foot therapeutic material 7 is not displaced from the affected part, and the therapeutic material pressing tool 4 is attached. In the condition, wearing socks, working as usual, and performing treatment to replace athlete's foot treatment material 7 at the time of bathing, all the affected areas were completely cured in 12 days.

<Treatment Example 3>
-Intercostal athlete's foot Male 40 years of medical history Over 10 years Symptoms: Athlete's foot developed between all the fingers of both feet, the skin was white and dandruff, and some of the skin also had bleeding from subcutaneous fat. It was also accompanied by a very strong itch.

  Treatment result: The athlete's foot treatment material 7 is sandwiched between the fingers of the affected part, the therapeutic material pressing tool 4 is attached so that the athlete's foot therapeutic material 7 is not displaced from the affected part, and the therapeutic material pressing tool 4 is attached. In the condition, wearing socks, working as usual, and performing treatment to replace athlete's foot treatment material 7 at the time of bathing, all the affected areas were completely cured in 16 days.

  Thus, the skin disease caused by ringworm fungus that has not been completely cured with conventional commercially available athlete's foot treatments has been treated with the skin disease treatment material caused by ringworm fungus according to the present embodiment (athlete's foot). By using the therapeutic material 7), it was confirmed that all cases had a very high therapeutic effect that they were completely cured in about 2 weeks and never recurred.

  In addition, in this example, it is a skin disease skin disease treatment material (aquatic foot treatment material 7) caused by ringworm fungus using gaseous execetin as an active ingredient for anti-tinea, but in addition to this gaseous execetin, for example, Anti-pyridine alkaloids such as trigonene, piperine, lobeline, pseudoperetierin, coniine, calpain, nornicotine, nicotine, α-nicotiline, β-nicotiline, nicotinic acid, nicotinonitrile, arekaidin, arecoline, anabasine, ricinine, lithinin It may be used as an active ingredient of ringworm, and when these are used, it becomes a therapeutic agent for skin diseases caused by ringworm, which can exhibit an excellent antibacterial (bactericidal) effect against ringworm like execetin.

  A second embodiment of the present invention will be described with reference to the drawings.

In this example, an alkaloid compound composed of carbon, hydrogen and nitrogen and having a molecular formula represented by C _x H _y N ₂ is used as an anti-tinea fungus active ingredient, and the alkaloid compound as an anti-tinea fungus active ingredient is in a gaseous state. In addition, an anti- ringworm fungus active ingredient generating part 2 containing this gaseous alkaloid-based compound can be attached to the affected area and is a therapeutic agent for skin disease caused by ringworm fungus.

  Specifically, the anti-tinea fungus active ingredient generating part 2 is configured in the roll-shaped sheet described in Example 1, and the roll-shaped sheet is configured in the adhesive bandage type provided in the adhesive sheet 9, and the athlete's foot treatment material 7 is a dermatosis-causing agent for dermatosis caused by nicotine as an active ingredient for anti-tinea fungus contained in the active ingredient generating part 2 for anti-tinea fungus.

  The nicotine used in this example was generated from alkaloids contained in the leaves of a plant of the solanaceous plant. Specifically, for example, tobacco leaves were dried in the sun, crushed, It is dehydrated by applying hot air, and the dehydrated material is further crushed and burned (steamed) to produce nicotine-containing smoke, that is, nicotine in a gaseous state.

  In other words, nicotine, which is an anti-tinea fungi active ingredient shown in the present example, is contained in the anti-tinea fungus active ingredient generator 2 configured in a roll-like sheet made of fibers in a gaseous state that is fine particles of smoke. By attaching the anti-tinea fungi active ingredient generating part 2 configured in a roll-shaped sheet to the affected part, the skin respiration inside the skin cells where the causative fungus is present, specifically into the deep part of the stratum corneum It is configured to penetrate.

  In addition, 0.8 mg to 1.2 mg is appropriate for the nicotine component to be contained in the anti-tinea fungi active ingredient generator 2 configured in the roll sheet, and in this embodiment, the nicotine component content is set to 1.0 mg. is doing. Furthermore, the moisture content contained in the anti-tinea fungi active ingredient generator 2 configured in the roll sheet is appropriate to be 20% or less, and in this embodiment, the moisture content is set to 10% to 16%. ing.

In addition, the adhesive sheet 9 provided with the anti-tinea fungi active ingredient generator 2 configured in a roll-shaped sheet,
It is formed in a band shape having a wide attachment portion 10 for attaching an anti-tinea fungus active ingredient generation portion 2 to the central portion, and a ventilation hole 11 is formed on the entire surface.

  In this example, gaseous nicotine is obtained from tobacco leaves, which are natural solanaceous plants, but this nicotine can also be produced chemically, and gaseous nicotine is produced. The method for obtaining the above is not limited to the method shown in this embodiment, and is appropriately adopted.

  Since the present embodiment is configured as described above, the following effects can be obtained.

  The athlete's foot treatment material 7 of the present embodiment is formed by forming the anti-tinea fungus active ingredient generating portion 2 containing the anti-tinea fungus active ingredient in a roll-shaped sheet, and forming both ends of the roll-shaped sheet in an inclined shape by inverting the base. By configuring the shape, the contact area to the affected area can be further increased, and this roll is also used when coming into contact with a three-dimensional affected area such as between the toes (the root and the inside of the fingers on both sides). Even if the anti- ringworm fungus active ingredient generator 2 configured on the sheet is bent, the anti-tinea fungus active ingredient generator 2 can be reliably attached.

  Moreover, by providing a large number of ventilation holes 11 in the adhesive sheet 9 for attaching the anti-tinea fungus active ingredient generator 2 to the affected part, the air permeability to the affected part is improved, and the anti-tinea fungus active ingredient generator 2 The active ingredient of anti-tinea fungus contained in can be reliably attached to and penetrated into the affected area, and can be an excellent dermatosis-causing agent for tinea fungus factor having a high therapeutic effect.

  Furthermore, by setting the content of the anti-tinea fungus agent containing gaseous nicotine as an active ingredient to 1.0 mg, there is no adverse effect on the human body, and the moisture content of the anti-tinea fungus active ingredient generating part 2 By reducing the humidity to 10% to 16%, it is possible to eliminate moisture, which is the survival condition of ringworm bacteria, to surely kill ringworm bacteria, and to completely cure skin diseases such as athlete's foot and insects caused by this ringworm. It is an epoch-making material for treating skin diseases caused by groundbreaking trichophyton, which has a very high therapeutic effect.

In this example, gaseous nicotine is used as an active ingredient for anti- ringworm bacteria, but an alkaloid compound composed of carbon, hydrogen and nitrogen and having a molecular formula represented by C _x H _y N ₂ , for example, 4 -Cyanopyridine, 1-ethyl-1,4-dihydronicotinonitrile, 1-butyl-1,4-dihydronicotinonitrile, 1,4-dihydro-1-propylnicotinonitrile, 3-cyanopyridine, 1, 4-dihydro-2-isopropyl-6-phenylnicotinonitrile, 2- (phenylethynyl) -5-phenylnicotinonitrile, avanacin, nornicotine, isonicotitine, 1-methyl-2- (4-pyridinyl) pyrrolidine, meta Nicotine, α-nicotine, (R) -noriconicotine, N-ethylnornicotine, 4-isonornicotine, 2-isonornicotine 2-isonicotine, 4-isonicotine, 6-ethylnicotine, N′-benzylnornicotine, (+)-nicotine, (±) -nicotine, N-methylnicotine, (±) -nornicotine, trans-metanicotine N-propylnornicotine, N-butylnornicotine, nicotyline (β-nicotyline), 2- (1-methyl-1H-pyrrol-2-yl) pyridine (α-nicotyline), 3- (2-pyrrolyl) pyridine Further, a configuration using dihydronicotiline may be used, and when these are used, an excellent effect as the athlete's foot treatment material 7 can be exhibited in the same manner as nicotine.

  Next, the results of an antibacterial test of gaseous nicotine used in this example against ringworm bacteria are shown below.

  In order to confirm the antibacterial activity of nicotine gasified as an active ingredient of anti- ringworm fungus, antibacterial activity was examined with reference to JIS L 1902: 2008 “Antimicrobial test method and antibacterial effect of textile products” 9 Qualitative test (Hello method) A force test was performed. However, the test bacterium Ringworm is a single strain, and the pre-culture medium of this ringworm is potato dextrose agar medium, the bacterial solution preparation solution is 0.005% dioctyl sodium sulfosuccinate solution, and the plate medium is Sabouraud agar medium. The culture was performed at 25 ° C. for 7 days.

  In this antibacterial test, three sheet-like fibers containing gaseous nicotine were prepared as specimens, and two of these specimens were prepared by adding gaseous nicotine to sheet-like fibers as in this example. The remaining one specimen has a gaseous nicotine content of 1.0 mg in the same manner as the two specimens described above, and the moisture content is adjusted to 10% to 16%. Although it was made to contain, it was set as the state which increased the moisture content to 70%-80%.

  Regarding the test results, that is, the presence or absence of halo (growth inhibition zone) formation against ringworm of the test strain, 1.0 mg of gaseous nicotine was contained, and the water content was adjusted to 10% to 16% 2 One specimen showed a halo (growth inhibition zone) (the formation of a growth inhibition zone was confirmed), and the width of this halo (growth inhibition zone) was 21.5 mm.

  In addition, halo (growth inhibition zone) was not observed in the sample whose water content was increased to 70% to 80%.

  From the above, the superiority of the antibacterial effect against ringworm fungus was confirmed in a specimen constructed in the same manner as the athlete's foot treatment material 7 shown in this example.

  As described above, the inventor actually used the athlete's foot treatment material 7 shown in the present example, which has been confirmed to have antibacterial effects against ringworm fungi, and used the subject as a subject to confirm the therapeutic effect. Is described below.

  The affected area of the subject, that is, the athlete's foot affected area was between the toes of both feet, and the affected area was in a state where the fingers were cracked and blood was bleeding, and itching was also accompanied. Thus, the skin disease treatment material 2 of this example was attached to a relatively severe athlete's foot, and the therapeutic effect was confirmed.

  Specifically, the athlete's foot treatment material 7 provided with the anti-tinea fungus active ingredient generating part 2 comprising gaseous nicotine as a roll sheet as an anti-tinea fungus active ingredient is attached to the affected part, and the athlete's foot therapeutic material 7 is attached to the affected part. The therapeutic material stopper 4 is worn so that it does not deviate from or come off from the state where it is attached to the shoe, and the sock is worn with the therapeutic material stopper 4 being worn, and the shoe or rubber boots are worn in this state. The treatment was performed while performing the normal work, and the therapeutic effect was confirmed.

  In addition, the therapeutic material pressing tool 4 used in the present embodiment employs the same therapeutic material pressing tool 4 shown in the first embodiment.

  As treatment conditions, the athlete's foot treatment material 7 is replaced every day, the treatment material retainer 4 is continuously used, and the footwear is not new, and it is used continuously without washing what was previously used. In addition, when you are in the room, always wear the treatment material restraint 4 and wear socks on it, and at bedtime, wear only the athlete's foot treatment material 7 and the treatment material restraint 4 It was in a state.

  Thus, when the therapeutic effect was confirmed, all the athlete's foot which developed between the toes of both feet in seven days (a total of eight affected parts) were completely cured.

  Thus, in this example, many commercially available athlete's foot drugs are spray type or ointment type, whereas nicotine, which is an active ingredient of anti-tinea, is used as gaseous fine particles such as smoke. In a state, it is contained in the anti-tinea fungus active ingredient generator 2, and the action of skin respiration causes the inside of skin cells, specifically the gaseous nicotine, which is an anti-tinea fungus active ingredient, to reach the deep part of the stratum corneum. What can be easily done without causing irritation to the skin, and thus without causing the skin defense action, the anti-tinea fungus active ingredient contained in the anti-tinea fungus active ingredient generator 2 is continuously applied over a long period of time. Because it does not need to be treated many times a day unlike conventional athlete's foot treatment, treatment can be continued without being noticed by others. Completely cure The patient can satisfy all of the following three points: to always improve the ventilation of the affected area, to continue treatment for a long time while living a normal life, and to be able to treat without being noticed by others. It is an unprecedented breakthrough for the treatment of skin diseases caused by ringworm fungi, which is satisfactory and extremely effective.

  Note that the present invention is not limited to the first and second embodiments, and the specific configuration of each component can be designed as appropriate.

DESCRIPTION OF SYMBOLS 1 Anti- ringworm bacteria active ingredient generator 2 Anti- ringworm bacteria active ingredient generation | occurrence | production part 3 Ventilation hole 4 Treatment material pressing part 5 Finger insertion part 6 Locking part

Claims (12)

  An anti- ringworm fungus active ingredient that contains an anti-tinea fungus active ingredient that gives antibacterial and bactericidal action against ringworm, a causative agent of athlete's foot and insects, in a gaseous state or that can be released in the form of a gas An anti- ringworm fungus active ingredient generator having a generating agent, and releasing the gaseous anti-tinea fungus active ingredient from the anti-tinea fungus active ingredient generator and supplying the released gaseous anti-tinea fungus active ingredient to the affected area A material for treating skin diseases caused by ringworm fungus, characterized in that it can be attached and penetrated.   The dermatophytosis factor skin disease treatment material according to claim 1, wherein the anti-tinea fungus active ingredient generating part containing the anti-tinea fungus active ingredient in a gaseous state is made of fiber.   The anti-tinea active ingredient generator having the anti-tinea active ingredient generator comprises the gas-like anti-tinea active ingredient generated from the anti-tinea active ingredient generator in a breathable manner. The therapeutic agent for skin diseases caused by ringworm fungus according to claim 1.   The anti-tinea active ingredient generator is formed into a granular shape, and the anti-tinea active ingredient generator having the granular anti-tinea active ingredient generator is capable of moving the granular anti-tinea active ingredient generator freely A vent for discharging the gaseous anti-scabies active ingredient generated from the movable anti-scabergic fungus active ingredient generator to the outside of the anti-scabergic fungus active ingredient generating part, with a storage structure The material for treating dermatosis caused by ringworm fungus according to any one of claims 1 and 3, wherein:   The material for treating dermatosis caused by ringworm fungus according to any one of claims 1 to 4, wherein the active ingredient against anti-ringworm is a pyridine alkaloid.   The pyridine alkaloids are trigonene, piperine, lobeline, pseudoperetierin, conine, calpain, execetin, nornicotine, nicotine, α-nicotyrin, β-nicotiline, nicotinic acid, nicotinonitrile, arekaidin, arecoline, anabasine, ricinine, The material for treating skin diseases caused by ringworm fungus according to claim 5, wherein the material is selected from lithinin. Carbon, hydrogen and configured molecular formula with nitrogen and C _x H _y N ₂ represented by alkaloid compounds anti trichophyton active ingredient, and the alkaloid compound is the anti-Trichophyton active ingredient in a gaseous state, the gas A therapeutic agent for dermatosis caused by ringworm fungus, characterized in that an active portion of an anti- ringworm fungus containing an alkaloid-based compound is attached to the affected area.   The dermatosis-causing agent for ringworm fungus factor according to claim 7, wherein the alkaloid compound which is an active ingredient of the anti-ringworm fungus is selected from nicotine, nicotinonitrile, α-nicotyrin, and β-nicotiline.   9. The skin of the ringworm fungus factor according to any one of claims 7 and 8, wherein the anti-tinea fungus active ingredient generator has a content of the alkaloid compound of 0.8 mg to 1.2 mg. Disease treatment material.   The material for treating dermatosis caused by ringworm fungus according to any one of claims 7 to 9, wherein the anti- ringworm fungus active ingredient generating part has a water content of 20% or less.   The anti-tinea bacterium active ingredient generating part is made of fiber, and the anti-tinea bacterium active ingredient generating part made of this fiber is formed in a roll shape to form a roll-like sheet, The material for treating skin diseases caused by ringworm fungus according to any one of claims 7 to 10, wherein the material is capable of adhering to the skin.   The skin disease treatment material of the ringworm fungus factor according to any one of claims 1 to 11 and the treatment material pressing for pressing the skin disease treatment material of the ringworm fungus factor attached between the toes as the affected part. It is a skin disease treatment tool for ringworm fungus factor consisting of a tool, wherein the treatment material pressing tool is formed of a material having air permeability, and is provided with a finger insertion part for inserting each finger of one foot on one end side, The other end side is provided with a locking portion that locks in a pressed state on the heel or ankle, and is provided with a pressing portion that presses against the dermatosis-causing agent for causing ringworm fungus between the finger insertion portions. The skin disease treatment tool of ringworm fungus factor.

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