CN105193845B - A kind of externally-applied medicinal composition and preparation method thereof for treating underarm odor - Google Patents
A kind of externally-applied medicinal composition and preparation method thereof for treating underarm odor Download PDFInfo
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- CN105193845B CN105193845B CN201510607097.7A CN201510607097A CN105193845B CN 105193845 B CN105193845 B CN 105193845B CN 201510607097 A CN201510607097 A CN 201510607097A CN 105193845 B CN105193845 B CN 105193845B
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Abstract
A kind of externally-applied medicinal composition and preparation method thereof for treating underarm odor, is related to medicine.A kind of externally-applied medicinal composition for treating underarm odor of the present invention is grouped as by the group of following parts by weight：3~15 parts of borneol, 8~20 parts of Humuleno, 8~20 parts of β elemenes, 5~20 parts of carypohyllene, 5~20 parts of mercury, 5~20 parts of potassium nitrate, 5~20 parts of 12 hydrazine aluminum sulfate potassium, 8~18 parts of talcum powder, 5~20 parts of boric acid, 0.5~5 part of magnesium carbonate.Preparation method is first to absorb Humuleno, carypohyllene, β elemenes and mercury talcum powder and boric acid；Then borneol, potassium nitrate and 12 hydrazine aluminum sulfate potassium are crushed, crosses 150 mesh sieve；Finally it is mixed to get.A kind of externally-applied medicinal composition for treating underarm odor of the present invention is easy to use, only needs to be applied with, does not influence the daily life of patient.And it is rapid to work.
Description
Technical field
The present invention relates to a kind of externally-applied medicinal compositions for treating underarm odor.
Background technology
Underarm odor refers generally to bromhidrosis, and referring to the sweat of secretion has special stink or sweat to generate stink after decomposition.Often
It sends out below armpit, groin, foot, crissum, vulva, omphalos and female breast.Bromhidrosis caused by eccrine gland often with it is more
Sweat disease is occurred together, and position between vola pedis and toe is common in, because bacterial decomposition sweat generates stink.Apocrine sweat gland is influenced by endocrine,
It is active that puberty just starts secretion, due to the secretion of bacterium and apocrine sweat gland have an effect generate unsaturated fatty acid cause it is special
The formation of stink.
In general underarm odor can cause patient larger mental handicape, influence the social interaction of patient, serious meeting shadow
Ring the mental health of patient.Operation method is mainly used to the treatment of underarm odor at present, that is, cuts off a part of apocrine sweat gland and subtracts to reach
Few sweat secretion.Such method is not very applicable for each patient, and can be had some impact on to daily life.
Invention content
In view of the above-mentioned problems, the present invention provides a kind of externally-applied medicinal composition and preparation method thereof for treating underarm odor, for
The patient for not being suitable for operation can also achieve the purpose that treat underarm odor.
The externally-applied medicinal composition of the treatment underarm odor of the present invention is grouped as by the group of following parts by weight：3~15 parts of borneol, humulus
8~20 parts of oxalene, 8~20 parts of beta-elemene, 5~20 parts of carypohyllene, 5~20 parts of mercury, 5~20 parts of potassium nitrate, 12 hydrations
5~20 parts of alum, 8~18 parts of talcum powder, 5~20 parts of boric acid, 0.5~5 part of magnesium carbonate.
Further, it is grouped as by the group of following parts by weight：5~10 parts of borneol, 10~15 parts of Humuleno, beta-elemene 10
~15 parts, 10~15 parts of carypohyllene, 8~15 parts of mercury, 5~15 parts of potassium nitrate, 5~15 parts of 12 hydrazine aluminum sulfate potassium, talcum
10~15 parts of powder, 10~15 parts of boric acid, 1~3 part of magnesium carbonate.
Specifically, it is grouped as by the group of following parts by weight：8 parts of borneol, 12 parts of Humuleno, 12 parts of beta-elemene, carypohyllene
11 parts, 10 parts of mercury, 10 parts of potassium nitrate, 10 parts of 12 hydrazine aluminum sulfate potassium, 13 parts of talcum powder, 12 parts of boric acid, 2 parts of magnesium carbonate.
The preparation method of the externally-applied medicinal composition of the treatment underarm odor of the present invention includes the following steps：
(1) presses formula ratio, and Humuleno, carypohyllene, beta-elemene and mercury talcum powder and boric acid are absorbed；
(2) crushes borneol, potassium nitrate and 12 hydrazine aluminum sulfate potassium, crosses 150 mesh sieve；
(3) borneol, the potassium nitrate that obtains the middle processing of talcum powder and boric acid and step (2) that processing obtains in step (1)
With 12 hydrazine aluminum sulfate potassium and magnesium carbonate be uniformly mixed to get.
Further, the preparation method is that：First processing obtains in magnesium carbonate and step (1) talcum powder and boric acid are mixed
It closes uniformly, then is mixed with borneol, potassium nitrate and the 12 hydrazine aluminum sulfate potassium and magnesium carbonate that processing obtains in step (2)
It is even.
Specifically, the preparation method of the beta-elemene is as follows：It is crushed after curcuma zedoary is cleaned, under 0.3~0.5 atmospheric pressure
Steam distillation 5h collects gained distillate at 60~77 DEG C, keeps its saturation, separation upper layer organic to distillate plus sodium chloride
Mutually to get.
Specifically, the preparation method for stating Humuleno and carypohyllene is as follows：It is crushed after humulus grass is cleaned, 0.3~0.5 air
Steam distillation 8h is depressed, gained distillate at 65~150 DEG C is collected, makes its saturation to distillate plus sodium chloride, detaches upper layer
Organic phase is carried out rectifying by organic phase, is collected 166~168 DEG C of groups and is divided into Humuleno, is collected 254~257 DEG C of groups and is divided into China pink
Alkene.
In component according to the present invention：
Borneol：Acrid flavour, hardship, are slightly cold；The thoughts of returning home, liver, lung channel；There is Delicate fragrance a surname dissipate inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison, improving eyesight to move back
The effect of screen, cure mainly high fever apoplexy coma due to blocking of the respiratory system shies epilepsy, apoplexy coma due to blocking of the respiratory system shies epilepsy, summer-heat and damp blinds clear key, aphtha tooth swells, sore carbuncle infantile malnutrition due to digestive disturbances or intestinalparasites hemorrhoid, hot eyes is swollen
Bitterly, pterygium.
Humuleno and carypohyllene are Herba humuli scandentis extract, have clearing heat and detoxicating, inducing diuresis to remove edema.Carbuncle furuncle poison is controlled in external application, eczema,
Venomous snake bite.According to《The side of walking alone》Described in, there is therapeutic effect to bedsore.
Beta-elemene is a kind of sesquiterpenoids, can reduce tumour cell mitotic capabilities, and induced tumor is thin
Born of the same parents' apoptosis inhibits the growth of tumour cell.
Mercury：The effect of with desinsection and delousion.For skin scabies, stubborn dermatitis；It goes out head louse.
Potassium nitrate：Also known as nitre, ward off it is dirty wash turbid, product of assaulting fortified position brokenly, sharp watery diarrhea is real, removing toxicity for detumescence.Cure mainly heat day wound it is cold, tremble with fear
Heat is vomited and diarrhoea, lump in the abdomen lump in the abdomen lump in the abdomen, neck scrofula, abdominal pain due to blood stasis, the black subcutaneous ulcer of jaundice, sandstone leaching pain, headache, larynx numbness, hot eyes, sore swollen toxin.
12 hydrazine aluminum sulfate potassium：Also known as alum, cold in nature sour, return lung；Spleen；Liver；Large intestine；Bladder warp.With dissolving phlegm,
The effect of eliminating dampness, antidiarrheal, hemostasis.External application can detoxify desinsection, and eliminating dampness is antipruritic
Talcum powder：Heat-clearing, excreting dampness, sharp key.Control hot summer weather polydipsia, difficult urination, watery diarrhea, hot dysentery, gonorrhoea, jaundice, oedema, nosebleed
Blood, tinea pedis, skin moisture fester.
Boric acid：This product is external application fungicide, disinfectant, astringent and preservative.There is inhibition to make various bacteria, mould
With.It can with the amino in bacterio protein in conjunction with and play a role.It can be used for skin, mucous membrane, wound, oral cavity, vagina, bladder
Equal irrigation and disinfections, it can also be used to otitis, burn, scald, eczema etc..
Magnesium carbonate：Medicine intermediate, antacid, drier, color stabilizer, carrier, anti-caking agent.
Inventor has surprisingly found that the pharmaceutical composition for combining said components has treats underarm odor well
Effect, it is easy to use, it only needs to be applied with, does not influence the daily life of patient.And it is rapid to work.
In order to better understand and implement, the following detailed description of the present invention.
Specific implementation mode
Prepare embodiment
The preparation method of the externally-applied medicinal composition of the treatment underarm odor of the present invention includes the following steps：
(1) preparation of beta-elemenes：It crushes, steam distillation 5h under 0.3~0.5 atmospheric pressure, receives after curcuma zedoary is cleaned
Gained distillate at 60~77 DEG C of collection makes its saturation to distillate plus sodium chloride, separation upper organic phase to get.
(2) preparation of Humulenos and beta-elemene：It is crushed after humulus grass is cleaned, vapor under 0.3~0.5 atmospheric pressure
8h is distilled, gained distillate at 65~150 DEG C is collected, makes its saturation to distillate plus sodium chloride, detaches upper organic phase, will have
Machine mutually carries out rectifying, collects 166~168 DEG C of groups and is divided into Humuleno, collects 254~257 DEG C of groups and is divided into carypohyllene.
(3) presses 1 formula ratio of table, and the Humuleno obtained in step (1) and (2), carypohyllene, beta-elemene and mercury are used
Talcum powder and boric acid absorb.
(4) crushes borneol, potassium nitrate and 12 hydrazine aluminum sulfate potassium, crosses 150 mesh sieve.
(5) presses 1 formula ratio of table, is first uniformly mixed magnesium carbonate with the talcum powder and boric acid that processing obtains in step (3),
It is uniformly mixed again with borneol, potassium nitrate and the 12 hydrazine aluminum sulfate potassium and magnesium carbonate that processing obtains in step (4).
<1 each component formula ratio of table, in parts by weight>
Skin irritation test embodiment
Tested material：Prepare Examples 1 to 5 sample made from embodiment.
Subject：Healthy People totally 36 people, men and women is fifty-fifty, 20~30 years old age, meets subject and volunteers inclusion criteria.
Test method：Tested material is put into spot examination device, dosage 0.02g.Control wells are that blank control (does not set any object
Matter).Back or the forearm song side of subject will be pasted on non-stimulated adhesive tape added with the spot of tested material examination device, gently being pressed with palm makes
Be equably pasted on skin, continue for 24 hours.It removes tested material spot and tries 30min after device, observation skin is anti-after impression disappearance
It answers.If result is feminine gender, observed again respectively with 48h for 24 hours after patch test primary.By (the skin adverse reaction grade scale of table 2
Table) record reaction result.
<2 skin adverse reaction grade scale table of table>
Test result is shown in Table 3：
<Table 3 removes assessment result after tested material>
The result observed again respectively with 48h for 24 hours after patch test is the same as table 3.The above results show that treatment underarm odor of the invention
Externally-applied medicinal composition to the nonirritant effect of human skin.
Effect example
Application method：Medicinal powder is picked with common cotton swab, is applied to oxter, 3 times a day.
Efficacy assessment standard
1, it cures：After perspiration, oxter free from extraneous odour；
2, effectively：After perspiration, in 20 cm distance of armpit, stink is substantially reduced, and profuse sweating in the armpit is reduced, and patient is not interfered to restore just
Normal social activity；
3, invalid：After perspiration, for 20 centimetres of outer stinks of armpit without improving or mitigating, profuse sweating in the armpit is interfering patient just without significantly reducing
Normal social activity.
Case is as follows：
Mr. Li：40 years old, suffers from 8 years underarm odor time, using the drug obtained by the embodiment of the present invention 2, be cured entirely after 20 days.
Mr. Chen：Suffer from 5 years underarm odor time within 35 years old, using the drug obtained by the embodiment of the present invention 3, is cured entirely after 16 days.
Mr. Deng：Suffer from 3 years underarm odor time within 25 years old, using the drug obtained by the embodiment of the present invention 3, is cured entirely after 15 days.
Ms Zhang：Suffer from 5 years underarm odor time within 30 years old, using the drug obtained by the embodiment of the present invention 4, is cured entirely after 15 days.
Mrs Li：Suffer from 7 years underarm odor time within 33 years old, using the drug obtained by the embodiment of the present invention 2, is cured entirely after 20 days.
The invention is not limited in the above embodiments, if the various changes or deformation to the present invention do not depart from the present invention
Spirit and scope, if these changes and deformation belong within the scope of the claim and equivalent technologies of the present invention, then this hair
It is bright to be also intended to comprising these changes and deformation.
Claims (5)
1. a kind of externally-applied medicinal composition for treating underarm odor, it is characterised in that be grouped as by the group of following parts by weight：Borneol 3~15
Part, 8~20 parts of Humuleno, 8~20 parts of beta-elemene, 5~20 parts of carypohyllene, 5~20 parts of mercury, 5~20 parts of potassium nitrate, 12
5~20 parts of hydrazine aluminum sulfate potassium, 8~18 parts of talcum powder, 5~20 parts of boric acid, 0.5~5 part of magnesium carbonate；
The preparation method of the beta-elemene is as follows：It is crushed after curcuma zedoary is cleaned, steam distillation under 0.3~0.5 atmospheric pressure
5h, collects gained distillate at 60~77 DEG C, makes its saturation to distillate plus sodium chloride, separation upper organic phase to get；
The preparation method of the Humuleno and carypohyllene is as follows：It is crushed after humulus grass is cleaned, water steams under 0.3~0.5 atmospheric pressure
Steam distillation 8h, collects gained distillate at 65~150 DEG C, makes its saturation to distillate plus sodium chloride, detaches upper organic phase, will
Organic phase carries out rectifying, collects 166~168 DEG C of groups and is divided into Humuleno, collects 254~257 DEG C of groups and is divided into carypohyllene.
2. the externally-applied medicinal composition for the treatment of underarm odor according to claim 1, it is characterised in that by the group of following parts by weight
It is grouped as：5~10 parts of borneol, 10~15 parts of Humuleno, 10~15 parts of beta-elemene, 10~15 parts of carypohyllene, mercury 8~15
Part, 5~15 parts of potassium nitrate, 5~15 parts of 12 hydrazine aluminum sulfate potassium, 10~15 parts of talcum powder, 10~15 parts of boric acid, magnesium carbonate 1
~3 parts.
3. the externally-applied medicinal composition for the treatment of underarm odor according to claim 2, it is characterised in that by the group of following parts by weight
It is grouped as：8 parts of borneol, 12 parts of Humuleno, 12 parts of beta-elemene, 11 parts of carypohyllene, 10 parts of mercury, 10 parts of potassium nitrate, Shi Ershui
Close 10 parts of alum, 13 parts of talcum powder, 12 parts of boric acid, 2 parts of magnesium carbonate.
4. a kind of preparation method of the externally-applied medicinal composition for the treatment of underarm odor according to claims 1 to 3 any one,
It is characterized in that including the following steps：
(1) presses formula ratio, and Humuleno, carypohyllene, beta-elemene and mercury talcum powder and boric acid are absorbed；
(2) crushes borneol, potassium nitrate and 12 hydrazine aluminum sulfate potassium, crosses 150 mesh sieve；
(3) borneol, the potassium nitrate and ten that obtains the middle processing of talcum powder and boric acid and step (2) that processing obtains in step (1)
Two hydrazine aluminum sulfate potassium and magnesium carbonate be uniformly mixed to get；
The preparation method of the beta-elemene is as follows：It is crushed after curcuma zedoary is cleaned, steam distillation under 0.3~0.5 atmospheric pressure
5h, collects gained distillate at 60~77 DEG C, makes its saturation to distillate plus sodium chloride, separation upper organic phase to get；
The preparation method of the Humuleno and carypohyllene is as follows：It is crushed after humulus grass is cleaned, water steams under 0.3~0.5 atmospheric pressure
Steam distillation 8h, collects gained distillate at 65~150 DEG C, makes its saturation to distillate plus sodium chloride, detaches upper organic phase, will
Organic phase carries out rectifying, collects 166~168 DEG C of groups and is divided into Humuleno, collects 254~257 DEG C of groups and is divided into carypohyllene.
5. the preparation method of the externally-applied medicinal composition for the treatment of underarm odor according to claim 4, it is characterised in that：First by carbon
Sour magnesium is uniformly mixed with processing obtains in step (1) talcum powder and boric acid, then borneol, the nitre obtained with the middle processing of step (2)
Sour potassium and 12 hydrazine aluminum sulfate potassium are uniformly mixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510607097.7A CN105193845B (en) | 2015-09-22 | A kind of externally-applied medicinal composition and preparation method thereof for treating underarm odor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510607097.7A CN105193845B (en) | 2015-09-22 | A kind of externally-applied medicinal composition and preparation method thereof for treating underarm odor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105193845A CN105193845A (en) | 2015-12-30 |
| CN105193845B true CN105193845B (en) | 2018-08-31 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635165A (en) * | 1995-09-27 | 1997-06-03 | Helene Curtis, Inc. | Antiperspirant deodorant compositions |
| CN203400332U (en) * | 2013-07-30 | 2014-01-22 | 牛太贵 | Bromhidrosis-resistance silver fiber medicinal patch |
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635165A (en) * | 1995-09-27 | 1997-06-03 | Helene Curtis, Inc. | Antiperspirant deodorant compositions |
| CN203400332U (en) * | 2013-07-30 | 2014-01-22 | 牛太贵 | Bromhidrosis-resistance silver fiber medicinal patch |
Non-Patent Citations (2)
| Title |
|---|
| 举起手来,向狐臭说"拜拜";吴志;《科技日报》;20120612;第2页第6-7段 * |
| 冰片的研究进展;陈艳红，等;《中国社区医师》;20131231;第15卷(第6期);第10页左栏第1段 * |
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