JP2011184378A - Intraoral disintegrating preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an intraoral disintegrating preparation of new dosage form which is simply produced and has a high medicine content. <P>SOLUTION: The intraoral disintegrating preparation is obtained by kneading a medicine or functionally coated medicine particles with a high-concentration sugar solution (e.g., a high-concentration sugar solution of a sugar selected from the group consisting of maltose, fructose and sucrose or a high-concentration sugar solution of a sugar alcohol selected from the group consisting of maltitol, xylitol, sorbitol and lactitol) having ≥70 wt.% sugar content as a solid content or ≥15 wt.% of an aqueous solution of a binder having a viscosity (25°C) of 5% aqueous solution of ≤55 mPa s, pulverizing the mixture and drying the pulverized product. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

The present invention relates to an orally disintegrating preparation that rapidly disintegrates in the oral cavity. The preparation referred to here is an oral preparation having the same function as a tablet, and “disintegrate rapidly” means that it disintegrates in the mouth usually within 1 minute, preferably within 30 seconds.

In recent years, intraoral rapidly disintegrating tablets have been noticed and various types have been invented as dosage forms for improving drug compliance and improving compliance of patients, particularly elderly people and children.
In the early days, Zydis (Non-Patent Document 1), in which a drug was dissolved in gelatin and freeze-dried, was developed. Then, in consideration of good solubility in the mouth, sugars containing sugar alcohols such as mannitol and xylitol were used as excipients. Orally disintegrating tablets have been studied. However, sugar alcohols are prone to problems such as sticking (adhering to the punch) and binding (adhering to the die) during tableting as they are.

In order to avoid the tableting trouble, when manufacturing an orally rapidly disintegrating tablet using sugar alcohol as an excipient, for example, a mixture containing sugar alcohol is moistened with appropriate moisture and compression molded at low pressure. Later, a special production method (Patent Document 1) for drying and tableting and a special device for producing the preparation have been developed (Patent Document 2).

On the other hand, orally disintegrating tablets, which are prepared by directly compressing a mixture of drugs and additives such as extenders and disintegrants, or drugs and additives such as extenders and disintegrants, are prepared by a wet process. Many devices have also been devised for the production of rapidly disintegrating tablets in the oral cavity that are almost infinitely similar to ordinary tablet manufacturing methods, such as orally disintegrating tablets that are granulated and dried using particles produced by drying. For example, a method of obtaining an orally disintegrating tablet by directly compression-molding (direct compression method) a mixture of a) active ingredient, b) D-mannitol having an average particle size of 30 to 300 μm, c) a disintegrant and d) celluloses. (Patent Document 3) has been devised. In addition, a method of obtaining an orally disintegrating tablet by humidifying and drying after producing a tablet using an amorphized saccharide has been devised (Patent Documents 4 and 5).
Recently, fine particles with an average particle size of about 400 μm or less containing drugs, etc., and having functions such as bitterness masking and sustained release, and a disintegrant, binder, and lubricant are added thereto, Patents for obtaining orally disintegrating tablets have been disclosed (Patent Document 6), and attention is focused on preparations using fine particles produced by applying such a functional coating.
In addition, many techniques for orally disintegrating tablets using saccharides and sugar alcohols have been disclosed, and in particular, powdered reduced water candy or water candy pulverized powder is also used as an additive (for example, Patent Document 7). In the production of a preparation using conventional water candy, powdered water candy (rice flour) and powdered reduced maltose water candy are used as they are or as a relatively low concentration aqueous solution. These powder raw materials and low-viscosity water candy solutions are superior to water candy (aqueous solution having a solid content of 75%) in terms of handling. However, when used in a powder or low-concentration sugar aqueous solution, it is different from the case where it is used at a high concentration such as water candy, especially from ordinary raw materials such as fine particles (average particle size is several hundred μm). However, when the particle size is slightly increased, sufficient bonding strength cannot be exhibited, and the resulting solid agent is fragile and unsuitable for practical use. Therefore, a high-concentration aqueous solution is required for bonding between the fine particles.
These preparations are designed so that they can be produced by the usual preparation method as much as possible except for some steps, but the physical properties and characteristics of the tablets are not perfect.

Manufacturing Chemist, Feb. vol. 36 (1990) JP 2000-344664 A JP-A-6-218028 Republished 2000-078292 Republished 1999-47124 JP 11-349475 A JP 2000-281564 A Japanese Patent Laid-Open No. 2005-53792

The oral solid preparations currently on the market are mainly tablets, capsules and powders. However, some drugs are administered to patients with weak swallowing ability, such as elderly people and children, and according to the disease field, for example, patients with weak swallowing ability such as low saliva in schizophrenia There are many. Under such circumstances, an orally disintegrating preparation that can be taken without water is also important in terms of enhancing patient compliance. Therefore, it is desired to develop an orally administered orally disintegrating preparation that is easy to take from the viewpoint of compliance.

The problem of the present invention is that the drug itself is a fine particle, or contains a high content of drug-containing fine particles having functions such as masking and sustained release, easily disintegrating in the oral cavity, and good dosing feeling And it is providing the orally disintegrating formulation which has sufficient intensity | strength, and its manufacturing method.

The present inventors have conducted intensive research on a method for producing an orally disintegrating preparation in which the drug itself is a fine particle, or a fine particle having an average particle diameter of about 400 μm or less having functions such as masking and sustained release. Carried out. As a result, using the fine particles, adding a disintegrant, a sweetener, etc., if necessary, kneading with a water-containing solution of saccharides or certain binders, shaping, and drying, the fine particle content is high The present invention was completed by finding that an orally disintegrating oral administration preparation having a good dosing feeling can be obtained.
That is, the present invention contains a high-concentration sugar-containing solution of a drug or drug-containing fine particles and water candy, or a water-containing solution of a certain binder, and further contains a disintegrating agent, a sweetening agent, a fragrance and the like. An orally disintegrating preparation is provided.

Specifically, in the case of saccharides, a water-containing solution of high-concentration sugar such as water candy and reduced maltose water candy (30% or more can be used, but preferably 70% or more) is used. In the case of an aqueous binder solution, a binder having a 5% aqueous solution viscosity (25 ° C.) of 55 mPa · s or less is added at a concentration of 15% by weight or more (for example, K30 of polyvinyl pyrrolidone and hydroxypropyl cellulose: HPC -If it is SSL, it is characteristic to use in the density | concentration of 20-30 weight%, etc., and an orally disintegrating formulation is provided by kneading | mixing a medicine containing fine particle etc., and shape-drying.

According to the present invention, in the preparation of an orally disintegrating preparation containing fine particles having an average particle diameter of about 400 μm or less having functions such as fine particles or masking and sustained release, the fine particle content is 50. It was possible to produce an orally disintegrating preparation with a high content of at least 90%, and in some cases 90%.

Moreover, the manufacturing method of said characteristic formulation is a simple process which consists of kneading | mixing, shaping | molding, and drying, and can manufacture an orally disintegrating formulation easily.

In the present invention, the drug itself is a fine particle, or a fine particle having an average particle diameter of about 400 μm or less having functions such as masking and sustained release, and if necessary, a disintegrating agent, a sweetener, etc. are added, and a saccharide Alternatively, the present invention relates to an orally disintegrating oral dosage preparation that can be satisfactorily taken by kneading with a water-containing solution of a certain binder, molding, and drying, and a method for producing the same.

The composition of the drug or drug-containing fine particles used in the orally disintegrating preparation of the present invention can be applied to many drugs as long as it is used as an oral medicine and is itself a fine particle or can be produced. it can. The fine particles have a size of about 400 μm or less, and may be a fine particle of crystalline cellulose, a fine particle of sucrose or the like coated with a drug or polymer, or a granulated fine particle.

The saccharide used in the orally disintegrating preparation of the present invention is not particularly limited as long as it is a pharmaceutically acceptable saccharide, and those usually used as sweeteners, excipients, stabilizers and the like can be used. Preferably, water malt containing maltose (maltose), dextrin and the like, and reduced maltose water cane containing reduced maltose (maltitol), the sugar content in the water can be 30% by weight or more, In order to obtain a solid agent having sufficient strength, it is preferably used at 70% by weight or more, which becomes water-like. In addition, it can also be prepared in a high concentration aqueous solution (syrup) such as xylitol, sorbitol, or lactitol.
Water candy is obtained by adding water to starch and heating it, and then gelatinizing it to add amylase and hydrolyzing it, and reducing it further is reduced maltose water candy. Water candy contains maltose, dextrin and the like, and reduced maltose water candy usually contains 70 to 95% by weight of maltitol. Commercially available water candy includes the product name “Malster” (registered trademark, Hayashibara Shoji: sugar solid content 74% or more), the product name “Mulltrap” (registered trademark, Hayashibara Shoji: sugar solid content 70% or more) Etc. In addition, as commercially available reduced maltose water candy, the product name “Mabit” (registered trademark, Hayashibara Shoji: sugar solid content 74% or more), the product name “Amarty Syrup” (registered trademark) (manufactured by Mitsubishi Corporation Foodtech: Sugar solid content of 74% or more). In addition, JP D-sorbitol solution (concentration 70%) can also be used. Other sugars may be used as much as possible as a highly concentrated aqueous solution or a water-containing solution (containing alcohol or the like).
Moreover, as long as a high concentration water containing solution can be prepared, you may mix and use them.

The binder used in the orally disintegrating preparation of the present invention is not particularly limited as long as it is a pharmaceutically acceptable binder, but a binder having a 5% aqueous solution viscosity (25 ° C.) of 55 mPa · s or less can be used. . Preferably, polyvinylpyrrolidone K30 and K90 grades (trade names “Collidon 30” and “Collidon 90”: manufactured by BASF and trade names “Prasidone K29 / 32” and “Prasudon K90”: manufactured by ISP), hydroxypropyl cellulose (commodity) The names “HPC-SSL” and “HPC-SL” (manufactured by Nippon Soda), etc., and the concentration of the water-containing solution may be 15% by weight or more.

The disintegrant used in the orally disintegrating preparation of the present invention is not particularly limited as long as it is a pharmaceutically acceptable disintegrant, but crystalline cellulose, low-substituted hydroxypropylcellulose, carboxymethylcellulose (carmellose), carboxy Starches represented by methylcellulose calcium (carmellose calcium), crospovidone; or potato starch, wheat starch, corn starch, rice starch, hydroxypropyl starch (HPS), sodium carboxymethyl starch, partially pregelatinized starch (PCS) Can be mentioned. These contents are 20% or less, and can be used alone or in combination of two or more. Particularly preferred are low-substituted hydroxypropylcellulose and crospovidone.

The sweetener used in the orally disintegrating preparation of the present invention (added as a powder in the same manner as the disintegrant) is not particularly limited as long as it is a pharmaceutically acceptable sweetener, but sucrose, maltose (maltose), which are the sugars described above ), Fructose, lactose, glucose, and sugar alcohols such as mannitol, maltitol, sorbitol, reduced palatinose, xylitol, erythritol, and the like. In addition, sweeteners such as aspartame, sucralose, acesulfame potassium and stevia can also be mentioned. Their content is less than a few percent. One or more of these can be used.

The fragrance used in the orally disintegrating preparation of the present invention (added as a powder in the same manner as the disintegrant) is not particularly limited as long as it is a pharmaceutically acceptable fragrance. For example, lemon, orange, menthol, mint oil, vanilla Etc., or powdered fragrances obtained by processing them.

Applicable to the present invention are those in which the drug itself is in the form of fine particles or fine particles containing the drug, and the average particle diameter is not particularly limited. From the viewpoint of roughness, the average particle size is preferably about 400 μm or less, but more preferably 300 μm or less.

Although it does not restrict | limit especially as a pharmaceutical component applicable to the said microparticles | fine-particles etc., The following pharmaceutical can be mentioned, for example.
Antipyretic / analgesic / anti-inflammatory agents include indomethacin, aspirin, diclofenac sodium, ketoprofen, ibuprofen, mefenamic acid, dexamethasone, dexamethasone sodium sulfate, hydrocortisone, prednisolone, azulene, phenacetin, isopropylantipyrine, acetaminophen, benzytamine hydrochloride, phenylbutamine Zon, flufenamic acid, sodium salicylate, choline salicylate, sazapyrine, clofesone, etodolac, felbinac. Antiulcer agents include sulpiride, cetraxate hydrochloride, gefarnate, irsogladine maleate, cimetidine, ranitidine hydrochloride, famotidine, nizatidine, roxatidine acetate hydrochloride, and sodium azulene sulfonate. Antibiotics include ampicillin, amoxiline, cephalexin, erythromycin ethyl succinate, bacampicin hydrochloride, minocycline hydrochloride, chloramphenicol, tetracycline, erythromycin, griseofulvin, cefditoren pivoxil, azithromycin, clarithromycin. Synthetic antibacterial agents include nalidixic acid, pyrometic acid, pipemidic acid trihydrate, enoxacin, sinoxacin, ofloxacin, levofloxacin hydrate, norfloxacin, ciprofloxacin hydrochloride, sulfamethoxazole / trimethoprim, and itraconazole. As antiviral agents, acyclovir and valaciclovir hydrochloride. As the antiseptic, propantheline bromide, atropine sulfate, oxobium bromide, timebidium bromide, butyl scopolamine bromide, trospium chloride, butropium bromide, N-methyl scopolamine methyl sulfate, methyl octatropine bromide. Anti-cough / anti-asthma / anti-allergic agents include theophylline, aminophylline, methylephedrine hydrochloride, procaterol hydrochloride, trimethquinol hydrochloride, codeine phosphate, sodium cromoglycate, tranilast, dextromethorphan hydrobromide, dimemorphan phosphate phosphate, hydrochloric acid Clobutinol, fominoben hydrochloride, benproperine phosphate, ambroxol hydrochloride, tipepidine hibenzate, eprazinone hydrochloride, epinastine hydrochloride, clofedanol hydrochloride, ephedrine hydrochloride, olopatadine hydrochloride, fexofenadine hydrochloride, noscapine, carbetapentene citrate, tannin Oxerazine acid, isoaminyl citrate, pranlukast, fluticasone propionate. As bronchodilators, diprofilin, salbutamol sulfate, chlorprenalin hydrochloride, formoterol fumarate, orciprenaline sulfate, pyrbuterol hydrochloride, hexoprenaline sulfate, bitorterol mesylate, clenbuterol hydrochloride, terbutaline sulfate, mabuterol hydrochloride, fenoterol hydrobromide, hydrochloric acid Methoxyphenamine. Muscle relaxants include chlorphenesin carbamate, tolperisone hydrochloride, eperisone hydrochloride, tizanidine hydrochloride, mephenesin, chlorzoxazone, phenprobamate, metcarbamol, chlormezanone, pridinol mesylate, afroqualone, baclofen, and dantrolene sodium. Minor tranquilizers include oxazolam, diazepam, clothiazepam, medazepam, temazepam, fludiazepam, meprobamate, nitrazepam, chlordiazepoxide, and quazepam. Major tranquilizers include sulpiride, clocapramine hydrochloride, sodepine, chlorpromadinone, haloperidol, risperidone, and olanzapine. Antihypertensive agents include enalapril maleate, valsartan, alacepril, delapril hydrochloride, candesartan cilexetin, nifedipine, isosorbite dinitrate, diltiazem hydrochloride, trapidil, dipyridamole, dilazep hydrochloride, verapamil, nicardipine, nicardipine hydrochloride, verapamil hydrochloride, pindolol, Propranolol hydrochloride, carteolol hydrochloride, metoprolol tartrate, labetalol hydrochloride, seriprolol hydrochloride, acebutolol hydrochloride, bufetrol hydrochloride, alprenolol hydrochloride, arotinolol hydrochloride, oxprenolol hydrochloride, nadolol, bucmolol hydrochloride, indenolol hydrochloride, timolol maleate , Befnolol hydrochloride, bupranolol hydrochloride, carvedilol, dimethylaminoethyl reserpinate hydrochloride, resinamine, Tildopa, prazosin hydrochloride, bunazosin hydrochloride, clonidine hydrochloride, budralazine, urapidin, furosemide, acetazolamide, trichlormethiazide, methiclotiazide, hydrochlorothiazide, hydroflumethiazide, ethiazide, cyclopenthiazide, spironolactone, triamterene, flurothiazide, furotathide Acid, azosemide, clofenamide. Antiarrhythmic agents include procainamide hydrochloride, disopyramide, azimarin, quinidine sulfate, aprindine hydrochloride, propaphenone hydrochloride, and mexiletine hydrochloride. Allopurinol, probenecid, colchicine, sulfinpyrazone, benzbromarone, bucolome as gout treatments. Anticoagulants include ticlopidine hydrochloride, dicoumarol, and warfarin potassium. Anti-epileptic agents include phenytoin, sodium valproate, metalbital, carbamazepine. Antihistamines include chlorpheniramine maleate, clemastine fumarate, mequitazine, alimemazine tartrate, and cycloheptadine hydrochloride. Antiemetics include diphenidol hydrochloride, metoclopramide, domperidone, betahistine mesylate, and trimebutine maleate. Sympathomimetic agents include dihydroergotamine mesylate, isoproterenol hydrochloride, and ethylephrine hydrochloride. As a leavening agent, bromhexine hydrochloride, carbocystine, ethylcysteine hydrochloride, methylcysteine hydrochloride. Oral diabetes treatment agents include glibengramide, tolbutamide, grimidine sodium, troglitazone, rosiglitazone, pioglitazone hydrochloride, epalrestat. As vitamin preparations, vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin B ₁₂ , vitamin C, folic acid. Frequent urinary and urinary incontinence treatments include flavoxate hydrochloride, oxybutynin hydrochloride, and terolidine hydrochloride. Tacrolimus, an immunosuppressant. Paclitaxel, docetaxel, bicalutamide as antineoplastic agents.

In the present invention, the drug itself is a fine particle, or a fine particle having an average particle diameter of about 400 μm or less having functions such as masking and sustained release, and if necessary, a disintegrating agent, a sweetener, etc. are added, and a saccharide Or a high-concentration water-containing solution, or a water-containing solution of a certain binder, and a method for producing an orally-disintegrating oral dosage preparation that can be satisfactorily taken by drying, molding and drying.
A further feature of the present invention is that when the drug itself is a fine particle, or an orally disintegrating preparation containing fine particles having an average particle diameter of about 400 μm or less having functions such as masking and sustained release, The present inventors have found a method for producing an orally disintegrating preparation having a fine particle content of 50% or more, and in some cases 90%.
In the case of an orally disintegrating preparation, the drug content in a solid preparation is often 50% or less, but according to the present invention, it can be produced into an orally disintegrating tablet having a drug content of 50% to about 90%. . However, in the case of a preparation containing fine particles having an average particle size of about 400 μm or less and containing a drug or the like and having functions such as bitterness masking and sustained release, the fine particle content is 50 to about 90%.
This is possible by adding a high-concentration saccharide solution of 70% or more, or a water-containing solution having a concentration of 15% by weight or more of a binder having a 5% aqueous solution viscosity (25 ° C.) of 55 mPa · s or less. This is because it has found a method of kneading and granulating, and this point has great value.
For the functional fine particles used above, for example, fine particles with an average particle size of 200 μm or less such as crystalline lactose, granulated sugar, corn starch, crystalline cellulose, D-mannitol, etc., and the outer layer is coated with the drug substance and the binder, Furthermore, the outer layer can be produced by a method such as coating a film for preventing bitterness or controlling elution, but the production method is not limited. Of course, it is free to use fine particles coated with a film for preventing bitterness and controlling elution on the drug substance itself.

The polymer coating agent used for bitterness masking and elution control may be any as long as it is well known in this field. For masking bitterness, water-insoluble polymers such as ethyl cellulose and Eudragit RS, or gastric polymers such as Eudragit E, Eudragit RD100, and polyvinyl acetal diethylaminoacetate are used. As the enteric coating agent, for example, a cellulose polymer such as hydroxypropylmethylcellulose acetate succinate, and an acrylic polymer such as Eudragit S and Eudragit L are used.

The orally disintegrating preparation of the present invention comprises the above drug-containing microparticles containing a sugar water-containing solution such as water candy or a 5% aqueous solution having a concentration of 15% by weight or more of a binder having a viscosity (25 ° C.) of 55 mPa · s or less. After kneading with a solution, it can be produced by molding in a wet state and drying.
The concentration of the aqueous sugar solution (particularly water candy) when kneading with the drug-containing fine particles is preferably 70% by weight or more. In addition, a water-containing solution having a concentration of 20 to 30% by weight for the polyvinyl pyrrolidone K30 grade as a binder and a concentration of 15 to 30% by weight for the K90 grade of polyvinyl pyrrolidone is preferable. Kneading can be carried out by stirring in a beaker on a small scale, but a kneading machine such as a planetary mixer or a kneader that is generally used may be used for the preparation of the preparation.

The composition thus kneaded is molded in a wet state with a weak pressure (100 kg / cm 2 or less). It is preferable to formulate in the form of an agglomerate of granules. What is necessary is just to dry the lump at 20-100 degreeC. If the drug is unstable in temperature, it may be vacuum dried at 20 to 40 ° C.

In order to mold from a composition obtained by kneading a drug-containing fine particle and an aqueous sugar solution or a water-containing solution of a certain binder, the kneaded composition may be directly molded in a wet state and then dried. For drying, natural drying, vacuum drying, oven drying, microwave drying, or the like can be applied.

The preparation molding machine can be manufactured by a light molding machine (apparatus) without using a large pressure as in the rotary type single tablet press for wet tableting developed for wet granules. Also, by filling many other molds, various methods can be taken, such as extruding wet grains in an extruded form and cutting them into a certain length. The shape may be any shape such as various shapes having a circular, elliptical, oval, square, or other surface shape, a cylindrical shape, or a caplet type, and a meteorite-type preparation is also suitable for the oral cavity. .
The shape of the preparation of the present invention is not particularly limited, for example, other than a circle, an elliptical shape, a donut-shaped variant, and the like. It can also be a divided preparation. Although the thickness is not particularly limited, 1 to 10 mm is appropriate, and 2 to 8 mm is preferable. In general, the thinner the thickness and the larger the surface area, the better the quick disintegration. The size is not particularly limited, but is determined depending on the drug content of the preparation. For example, when the content is low, it is easy to make a small preparation, but it is crafted depending on the composition of the fine particles.

EXAMPLES Next, although an Example is given and this invention is demonstrated more concretely, this is only an illustration and does not restrict | limit this invention.

Reference example 1:
Ambroxol hydrochloride was layered on the core of crystalline cellulose (trade name “Selfia CP102”: Asahi Kasei Chemicals) using a binder. An aqueous dispersion (solid content 20%) obtained by adding a plasticizer to Eudragit NE30D for sustained release was added to the obtained drug-containing fine particle nuclei, and a rolling fluidized bed granulator / dryer (Paurec Co., Ltd .: MP-01). ) Was used to produce fine particles containing ambroxol hydrochloride. The drug content of the microparticles is about 20%.

Reference example 2:
Pioglitazone hydrochloride was layered on the nucleus of crystalline cellulose (Selfia CP102) using hydroxypropylcellulose as a binder to prepare nuclei of fine particles containing pioglitazone hydrochloride. The obtained fine particle nuclei were spray coated with an ethanol-containing aqueous solution of Eudragit E100 using a rolling fluidized bed granulator / dryer (Freund Corporation: SFC-MINI) to give fine particles containing pioglitazone hydrochloride (drug content about 20%). Made.

Example 1:
Crystalline cellulose (trade name “Selfia CP102”: Asahi Kasei Chemicals) is used as a placebo for the drug-containing fine particles, and 8 parts thereof are 2.66 parts of maltose water candy (Malster: Hayashibara Corporation: sugar solid content 74% or more) ( 2 parts as a solid content) kneading dropwise, so that water candy is evenly blended into the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 2:
Serfia CP102 was used as a placebo for the drug-containing fine particles, and 8 parts thereof were kneaded dropwise with 2.66 parts (2 parts as solids) of reduced maltose water candy (Mabit: Hayashibara Shoji: sugar solid content of 74% or more), Incorporate water candy uniformly into fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 3:
Serfia CP102 was used as a placebo for the drug-containing fine particles, and 8 parts thereof were kneaded dropwise with 2.66 parts of water candy (Maltrap: Hayashibara Shoji: sugar solid content of 70% or more) (2 parts as solid content). Mix candy uniformly into fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 4:
Crystalline cellulose (trade name “Selfia CP305”: Asahi Kasei Chemicals) is used as a placebo for the drug-containing fine particles, and 8 parts thereof is 1.33 parts (1 part as a solid content) of maltose water candy (malster) dropwise. , Make water candy evenly blended into fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 5:
CP305 is used as a placebo for drug-containing fine particles, and 8 parts of it is kneaded with 1.33 parts (1 part as a solid content) of reduced maltose water candy (mabit), and the water candy is uniformly mixed with the drug-containing fine particles. Make it. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 6:
CP305 is used as a placebo for drug-containing fine particles, and 8 parts of it is kneaded with 1.33 parts of water candy (1 part as a solid content), so that water candy is uniformly blended with drug-containing fine particles. . The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 7:
Using CP102 as a placebo for drug-containing fine particles, 7.5 parts of it and 0.5 parts of low-substituted hydroxypropylcellulose (trade name “L-HPC LH-31” Shin-Etsu Chemical) 0.5 parts maltose water candy (Malster) 1.8 parts (1.4 parts as a solid content) are kneaded dropwise, and water candy is uniformly blended with the drug-containing fine particle mixture. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 8:
Using CP102 as a placebo for drug-containing fine particles, 7.5 parts of it and 0.5 parts of crospovidone (trade name “Collidon XL-10” BASF), 1.8 parts of reduced maltose candy (mabit) (solid) 1.4 parts as a fraction) knead dropwise, and uniformly blend the water candy with the drug-containing fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 9:
Using CP102 as a placebo for drug-containing microparticles, 1.7 parts of Japanese Pharmacopoeia D-sorbitol solution (concentration: 70%) (trade name “Sorbit D-70”, Mitsubishi Corporation Foodtech) was added to 6 parts (solid content). As 1.3 parts) and kneaded dropwise to make the D-sorbitol aqueous solution evenly blended with the drug-containing fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 10:
Using CP102 as a placebo for drug-containing microparticles, 3 parts of Japanese Pharmacopoeia D-sorbitol solution (concentration 70%) (Sorbit D-70: Mitsubishi Corporation Foodtech) is added to 7.5 parts and 0.5 parts of crospovidone. 0.0 part (2.1 parts as a solid content) is dropped and kneaded, and the D-sorbitol aqueous solution is uniformly mixed with the drug-containing fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 11:
Using CP102 as a placebo for drug-containing fine particles, 6 parts of it and 0.2 parts of erythritol (product food science) are dripped and kneaded with 1.8 parts (1.4 parts as a solid content) of maltose water candy (malster). Combine water candy uniformly with drug-containing fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 12:
Using CP102 as a placebo for drug-containing fine particles, 7.5 parts thereof and 0.5 parts of crospovidone are kneaded dropwise with 2.4 parts of reduced maltose water candy (mabit) (2 parts as solids), and water. Mix candy uniformly into drug-containing microparticles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 13:
Using CP102 as a placebo for drug-containing microparticles, 7 parts thereof, 1 part of crospovidone and 0.05 part of acesulfame K (Sanet: Nutrinova) 2.2 parts of maltose candy (malster) as a solid content. 65 parts) Knead dropwise to blend water candy uniformly into drug-containing fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 14
Serfia CP102 is used as a placebo for drug-containing fine particles, and 6 parts of it is kneaded with 1.5 parts of a 30% aqueous solution of polyvinylpyrrolidone (trade name “Collidon 30”: BASF), so that the polyvinyl pyrrolidone is uniformly blended with the fine particles. Make it. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 15:
Using Serfia CP102 as a placebo for drug-containing fine particles, 2.5 parts of a 30% aqueous solution of polyvinylpyrrolidone (trade name “Collidon 30”: BASF) is dripped and kneaded into 6 parts g and 0.5 parts of crosvidone. Incorporate pyrrolidone uniformly into fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 16:
Serfia CP102 as a placebo for drug-containing fine particles was used, and 7.5 parts thereof and 0.5 parts of crospovidone were dropwise kneaded with 1.5 parts of a 30% aqueous solution of polyvinylpyrrolidone (trade name “Collidon 90”: BASF). , Polyvinylpyrrolidone is uniformly blended into the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 17:
Using SELFIA CP102 as a placebo for drug-containing fine particles, 1.5 parts of a 20% aqueous solution of hydroxypropylcellulose (trade name “HPC-SSL” Nippon Soda) was dripped and kneaded into 6 parts thereof to make hydroxypropylcellulose into fine particles. Acclimate evenly. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 18:
Using SELFIA CP102 as a placebo for drug-containing fine particles, 7.5 parts thereof and 0.5 parts of crospovidone are kneaded with 2 parts of a 20% aqueous solution of hydroxypropylcellulose (HPC-SSL), and hydroxypropylcellulose is finely divided. Get evenly blended into. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 19:
Using ambroxol hydrochloride-containing microparticles (coated with Eudragit NE30D) prepared by the method described in Reference Example 1, 7.5 parts thereof and 0.5 parts of L-HPC (LH-31) were mixed with maltose water candy (Malster 1.83 parts (1.4 parts as a solid content) is kneaded dropwise, and water candy is uniformly blended with the drug-containing fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Example 20:
Using pioglitazone hydrochloride-containing fine particles (coated with Eudragit E100) prepared by the method described in Reference Example 2, 7.5 parts thereof and 0.5 parts of crospovidone were mixed with 1.83 parts of maltose candy (malster) ( 1.4 parts as a solid content) kneading dropwise to make the water candy uniformly blend into the drug-containing fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative example

In the comparative example, hydroxypropylcellulose (trade name “HPC-L”: Nippon Soda), hypromellose (trade name “TC-5R”: Shin-Etsu Chemical) and polyvinylpyrrolidone were used as binders, and their solution concentrations were changed. A formulation study was conducted.

Comparative Example 1:
Using SELFIA CP102, 1.5 g of a 5% aqueous solution of hydroxypropylcellulose (HPC-L) is dripped and kneaded into 6 g thereof, and HPC-L is uniformly blended with the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 2:
Serfia CP102 is used and 1.5 g of a 5% aqueous solution of hypromellose (TC-5R) is dripped and kneaded with 6 g of the same, so that hypromellose is uniformly blended with the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 3:
Using SELFIA CP102, 7.5 g of L-HPC (LH-31) and 0.5 g of a 5% aqueous solution of hydroxypropylcellulose are kneaded dropwise, and HPC-L is uniformly blended with the fine particles.
The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 4:
Serfia CP305 is used, and 1.5 g of a 5% aqueous solution of hypromellose (TC-5R) is kneaded dropwise with 7.5 g thereof and 0.5 g of crospovidone, so that hypromellose is uniformly blended with the fine particles.
The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 5:
Serfia CP102 was used and 1.5 g of a 20% aqueous solution of hydroxypropylcellulose (HPC-L) was kneaded dropwise with 6 g of the HPC-L.
Intimately blend into the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 6:
Using SELFIA CP102, 2.0 g of a 20% aqueous solution of hypromellose (TC-5R) is dripped and kneaded into 6 g of the same, so that hypromellose is uniformly blended with the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 7:
Using SELFIA CP102, 2.5 g of a 20% aqueous solution of hydroxypropylcellulose (HPC-L) is dripped and kneaded into 7.5 g thereof and 0.5 g of crospovidone, so that HPC-L is uniformly blended with the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 8:
Using SELFIA CP102, 7.5 g of L-HPC (LH-31) and 0.5 g of L-HPC (LH-31) are kneaded with 3 g of a 20% aqueous solution of hypromellose (TC-5R), so that hypromellose is uniformly mixed with the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 9:
2 g of a 5% aqueous solution of polyvinyl pyrrolidone (trade name “Collidon 30”: BASF) is dripped and kneaded with 6 g of SELFIA CP102, so that the polyvinyl pyrrolidone is uniformly blended with the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 10:
Using SELFIA CP102, 7.5g of the product and 0.5g of crospovidone were kneaded with 2.5g of 5% aqueous solution of polyvinylpyrrolidone (trade name "Collidon 30": BASF), and the polyvinylpyrrolidone was uniformly blended into the fine particles. Make it. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 11:
Using SELFIA CP102, 2.0 g of a 5% aqueous solution of hydroxypropylcellulose (HPC-SSL) is dripped and kneaded with 7.5 g thereof and 0.5 g of crospovidone, so that hydroxypropylcellulose is uniformly blended with the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 12:
Serfia CP102 is used, 1.5 g of 20% aqueous solution of hypromellose (TC-5E) is dripped and kneaded into 6 g thereof, and hypromellose is uniformly blended with the fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Comparative Example 13:
10% of hydroxypropylcellulose (HPC-L) was added to 7.5 g of ambroxol hydrochloride-containing fine particles (coated with Eudragit NE30D) and 0.5 g of L-HPC (LH-31) produced by the method described in Reference Example 1. 2.5 g of aqueous solution is dropped and kneaded, and HPC-L is uniformly blended with the drug-containing fine particles. The obtained wet granule was formed into a 9 mm diameter cylindrical shape with a thickness of 5 to 7 mm and vacuum dried at 40 ° C. for 12 hours to produce an orally disintegrating preparation (mass 200 to 250 mg).

Evaluation of the said Example and comparative example was performed by disintegration time measurement and hardness.
The disintegration time was measured according to the “disintegration test method” in the general test method of the 15th Japanese Pharmacopoeia.
The preparation (mass 200-250 mg) was thrown in, and the time required for the mass to pass through the mesh was measured by visual observation.

Moreover, about the placebo formulation (mass 200-250 mg) in which microparticles | fine-particles do not contain drugs like Serfia CP102 and CP305, the time which actually contains in a mouth and disintegrates was measured.

The results of measuring the hardness of the preparation (mass 200 to 250 mg) with a hardness meter (TC-75N: Okada Seiko) were as follows.

The following summarizes the results of disintegration time and hardness in Table 1 (Examples) and Table 2 (Comparative Examples).

In the preparations of Examples 1 to 20 (mass 200 to 250 mg), although the results of the disintegration test tend to be long, disintegration in the mouth was as fast as almost 1 minute. In Comparative Examples 1 to 13, in the examples having a low binder concentration (Comparative Examples 1 to 4, 9, 10, and 11), the disintegration time was fast, but it was brittle and did not exhibit hardness (see Table 2). In addition, when the concentration of the binder is high, the disintegration time tends to be extended.

All of Examples 1-20 were 10N or more, and were preparations with hardness. In the comparative example, the hardness was increased with hydroxypropylcellulose and hypromellose, but the disintegration was long and hard and did not become an orally disintegrating preparation. Further, when the concentration of polyvinyl pyrrolidone (K30) is 5 to 10%, a molded product having a hardness cannot be produced.

Each of the orally disintegrating preparations of the present invention obtained in the above examples had an appropriate hardness and easily disintegrated in the oral cavity. In addition, it was found that by adding a disintegrant and a sweetener, it can be formulated into an orally disintegrating preparation with a better feeling of administration.

Claims (11)

  15% by weight or more of a high-concentration saccharide solution containing 70% by weight or more of sugar as a solid content or a 5% aqueous solution having a viscosity (25 ° C.) of 55 mPa · s or less. Orally disintegrating preparation obtained by kneading with a water-containing solution of   The orally disintegrating preparation according to claim 1, wherein the drug or drug particles are fine particles having an average particle size of 400 µm or less.   The orally disintegrating preparation according to claim 2, comprising 50 to 90 wt% of the fine particles.   The orally disintegrating preparation according to claim 1, wherein a disintegrating agent is added to the drug or drug particles.   The orally disintegrating preparation according to claim 4, wherein the disintegrating agent to be added is 20 wt% or less of the preparation.   The oral disintegration of claim 4, wherein the disintegrant is selected from the group consisting of crystalline cellulose, starch, low substituted hydroxypropyl cellulose, crospovidone, croscarmellose sodium, carmellose calcium, sodium carboxymethyl starch, and mixtures thereof. Formulation.   The orally disintegrating preparation according to any one of claims 1 to 6, wherein the high-concentration saccharide solution containing 70 wt% or more of sugar as the solid content is selected from water candy, reduced maltose water candy, or reduced water candy.   The high-concentration saccharide solution containing 70 wt% or more of the sugar as the solid content is a high-concentration solution of sugar selected from maltose, fructose or sucrose, or a high concentration of sugar alcohol selected from maltitol, xylitol, sorbitol or lactitol The orally disintegrating preparation according to any one of claims 1 to 6, which is an aqueous solution.   As the binder, a water-containing solution having a concentration of 15 wt% or more of a binder whose viscosity (25 ° C.) of a 5% aqueous solution is 55 mPa · s or less is polyvinylpyrrolidone K30 and K90, hydroxypropyl cellulose (low viscosity Grade) and a water-containing aqueous solution of a binder selected from hypromellose.   The subdividing is carried out by placing a drug or drug particle kneaded with a high-concentration sugar solution into a mold, or by continuously extruding and cutting from an extruder. 9. The orally disintegrating preparation according to any one of 9 above. The orally disintegrating preparation according to claim 10, which is compressed at a pressure of 100 kg / cm ² or less during molding, and has a hardness that can withstand handling including packaging and dispensing after drying.