JP2011132169A - Liquid composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a transparent liquid composition for oral cavity which raises the adsorption effect on the surface of a tooth of cetylpyridinium chloride which has bactericidal activity to dental bacteria. <P>SOLUTION: The transparent liquid composition for oral cavity includes a specific calcium salt, cetylpyridinium chloride, an oil-soluble component, and a nonionic surfactant, wherein the formulation ratio of the nonionic surfactant to the oil-soluble component is 0.57-3.5. Especially, the difference (A)-(B) of the formulation amount of the calcium salt (A) and the nonionic surfactant (B) is desirably -0.25 to 0.15. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a transparent liquid oral composition that promotes the adsorption effect of cetylpyridinium chloride having bactericidal activity on oral bacteria on the tooth surface.

  Cetylpyridinium chloride not only has high bactericidal activity against oral bacteria, but also adsorbs to the oral mucosa and tooth surface, inhibits the adsorption of oral bacteria to the surface of the tooth and oral mucosa, improves oral hygiene, It is known to suppress plaque formation. Therefore, cetylpyridinium chloride is blended in many oral compositions for the purpose of preventing and improving periodontal diseases and bad breath.

  Various methods have been disclosed for further enhancing the bactericidal activity of the cationic bactericides such as cetylpyridinium chloride against oral bacteria. Patent Document 1 discloses that when cetylpyridinium chloride is combined with a lower alkyl ester of an N-long-chain acyl basic amino acid or a salt thereof, adsorption of cetylpyridinium chloride to teeth is promoted. -It is disclosed that the effect of promoting the adsorption of a cationic fungicide on a tooth by a lower alkyl ester of a long-chain acyl basic amino acid or a salt thereof is highest in a pH range of 5.5 to 6.5.

  Patent Document 3 discloses that when a specific compound is added to the composition for oral cavity in which a cationic fungicide and a nonionic surfactant are used in combination, the inactivation of the fungicide is effectively prevented. Is disclosed. Patent Document 4 discloses that when cetylpyridinium chloride is combined with a specific polyoxyethylene hydrogenated castor oil, it does not inhibit the adsorption of cetylpyridinium chloride to teeth as compared with other surfactants. Furthermore, in Patent Document 5, polyvinyl alcohol is used to enhance the adsorptivity of cetylpyridinium chloride to teeth. However, even with these techniques, there is a problem that the activity of cetylpyridinium chloride cannot be improved to a satisfactory degree.

JP-A-4-36231 JP-A-9-286712 JP 60-255717 A JP-A-4-173728 Japanese Patent Laid-Open No. 2003-113059

  This invention is providing the transparent liquid composition for oral cavity which improved the activity of cetylpyridinium chloride by improving the adsorption effect to the tooth surface of the cetylpyridinium chloride which has bactericidal activity with respect to bacteria in the oral cavity.

  As a result of intensive studies in view of such circumstances, the present inventors have formulated cetylpyridinium chloride, an oil-soluble component, a nonionic surfactant, and a specific calcium salt, and obtained a nonionic surfactant for the oil-soluble component. It has been found that when the blending ratio and blending amount difference of the agent are in a specific range, a transparent liquid oral composition is obtained in which the adsorption effect of cetylpyridinium chloride on the tooth surface is remarkably enhanced.

That is, this invention provides the composition for liquid oral cavity of the following items 1-6 especially.
Item 1.
Calcium salt which is at least one selected from the group consisting of calcium gluconate, calcium lactate, calcium chloride, calcium acetate, calcium L-ascorbate, calcium pantothenate, calcium propionate, calcium nitrate and calcium carbonate, and cetyl chloride It contains pyridinium, an oil-soluble component and a nonionic surfactant, and the blending ratio of the nonionic surfactant to the oil-soluble component is 0.57 to 3.5, and the oil-soluble component (A) and the non-ionic surfactant The transparent liquid composition for oral cavity, wherein the difference (A)-(B) in the blending amount of the ionic surfactant (B) is -0.25 to 0.15.
Item 2.
Item 2. The transparent liquid oral composition according to Item 1, wherein the oil-soluble component comprises an oil-soluble medicinal component and / or a fragrance.
Item 3.
Item 3. The transparent liquid composition for oral cavity according to Item 2, containing 0.1 to 0.5% by mass of an oil-soluble component.
Item 4.
The oil-soluble medicinal component is at least one selected from the group consisting of triclosan, tocopherol acetate, β-glycyrrhetinic acid, p-hydroxybenzoate, isopropylmethylphenol, tocopherol nicotinate and oil-soluble plant extract. Item 4. The transparent liquid composition for oral cavity according to any one of Items 2 and 3.
Item 5.
Item 5. The transparent liquid oral composition according to any one of Items 1 to 4, which contains 0.01 to 1.0% by mass of cetylpyridinium chloride.
Item 6.
Item 6. The transparent liquid oral composition according to any one of Items 1 to 5, wherein the nonionic surfactant is polyoxyethylene hydrogenated castor oil.
Item 7.
Item 7. The transparent liquid oral composition according to any one of Items 1 to 6, wherein the amount of ethyl alcohol is less than 1% by mass.
The present invention also provides a liquid oral composition characterized by not containing ethyl alcohol.

  The liquid oral composition of the present invention further enhances the activity of cetylpyridinium chloride to promote the adsorption effect on the tooth surface, thereby adsorbing oral bacteria that cause dental caries and periodontal disease on the tooth surface. It is possible to effectively inhibit the formation of plaque by inhibiting, and further maintain the appearance transparency on the formulation and improve the solution stability, thereby providing a transparent liquid oral composition. Good performance quality can be ensured.

  The transparent liquid oral composition according to the present invention contains cetylpyridinium chloride, an oil-soluble component, a nonionic surfactant, and a specific calcium salt, and further, the mixing ratio of the nonionic surfactant to the oil-soluble component 0.57 to 3.5, and the difference in blending amount of the oil-soluble medicinal component and the nonionic surfactant is −0.25 to 0.15. In the present specification, the blending ratio represents the blending mass ratio unless otherwise specified.

  Cetylpyridinium chloride used in the present invention is a cationic bactericidal agent contained in a quaternary ammonium compound and is widely used in the field of oral compositions. Such cetylpyridinium chloride can be blended in an amount of 0.01 to 1.0% by mass, preferably 0.01 to 0.5% by mass, more preferably, based on the total amount of the liquid oral composition of the present invention. 0.01-0.3 mass%, Most preferably 0.05 mass% can be mix | blended. If it is less than 0.01% by mass, the effect of adsorption of cetylpyridinium chloride on the tooth surface will be reduced. On the other hand, if it exceeds 1.0% by mass, problems such as bitterness and coloring of teeth will occur. Therefore, it is not preferable.

  Examples of the oil-soluble component used in the present invention include an oil-soluble medicinal component and a fragrance, and these can be used alone or both at the same time. Especially in this invention, it is preferable to use together an oil-soluble medicinal component and a fragrance | flavor as an oil-soluble component, and it is more preferable that an oil-soluble component is a fragrance | flavor containing an oil-soluble medicinal component and l-menthol.

  The oil-soluble medicinal component is not particularly limited. For example, as a bactericidal agent, a halogenated diphenyl ether such as triclosan (2 ′, 4,4′-trichloro-2-hydroxy-diphenyl ether) or a phenolic compound such as isopropylmethylphenol; Vitamin Es such as dl-α-tocopherol acetate, tocopherol succinate, tocopherol nicotinate as promoters; p-hydroxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate Oil-soluble plant extracts extracted with oil-soluble solvents such as glycyrrhetinic acid, oil-soluble licorice, oil-soluble sugar beet, oil-soluble arnica, oil-soluble chamomile, oil-soluble silicon, etc. It may be included in the liquid oral compositions of the present invention together. Among these oil-soluble medicinal ingredients, p-hydroxybenzoic acid ester is preferable from the viewpoint of further enhancing the bactericidal activity against oral bacteria, and among them, methyl paraoxybenzoate is particularly preferable. The compounding quantity of an oil-soluble medicinal ingredient is 0.01-1 mass% with respect to the composition whole quantity, Preferably it is 0.01-0.5 mass%, More preferably, it is 0.01-0.1 mass%. When the blending amount is less than 0.01% by mass, sufficient bactericidal power in the composition cannot be exhibited, and when it is more than 1% by mass, there is a risk of irritation to the oral mucosa, which is a practical problem. Since it may become, it is not preferable.

  Although it does not restrict | limit especially as a fragrance | flavor, It is preferable to use a mint-type fragrance | flavor. Mint flavors can be obtained by conventional methods. For example, menthol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove Oil, eucalyptus oil, pimento oil, anethole, eugenol, plum oil, menthone and the like can be used. Of these, menthol, spearmint oil, peppermint oil, and menthone can be preferably used. Of these, l-menthol is most preferred. These perfume materials can be used alone or in combination of two or more. The compounding quantity of a fragrance | flavor is 0.01-1 mass% normally with respect to the composition whole quantity, Preferably it is 0.05-0.5 mass%. If the blending amount is less than 0.01% by mass, the flavor is low and the usability is poor, and if it is more than 1% by mass, the flavor is too strong and the usability is poor, and further irritation may be increased, which is not preferable. .

  In addition, when an oil-soluble component consists of an oil-soluble medicinal component and / or a fragrance | flavor, it is preferable to mix | blend 0.1-0.5 mass% of oil-soluble components with respect to the composition whole quantity, and 0.1-0. It is more preferable to add 4% by mass.

  The nonionic surfactant used in the present invention is not particularly limited, but is sugar sugar fatty acid ester such as sucrose fatty acid ester or maltose fatty acid ester; sugar alcohol fatty acid ester such as maltitol fatty acid ester; sorbitan fatty acid such as sorbitan monolaurate Esters; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monolaurate and polyoxyethylene sorbitan monostearate; fatty acid alkanolamides such as lauric acid diethanolamide; polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, etc. Polyoxyethylene alkyl ethers; polyethylene glycol fats such as polyethylene glycol monooleate and polyethylene glycol monolaurate Esters; alkyl glucosides such as lauryl glucoside and decyl glucoside; polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene fatty acid esters, alkyl glucosides, polyoxyethylene hydrogenated castor oil, glycerin fatty acid esters, polyoxyethylene propylene blocks A copolymer etc. are mentioned, Each can be mix | blended individually or in mixture of 2 or more types. Among these nonionic surfactants, polyoxyethylene hydrogenated castor oil is preferred, and the average added mole number of ethylene oxide is usually 2 to 150, preferably 40 to 100, more preferably 40 to 80. . A nonionic surfactant can mix | blend 0.001-1 mass%, and it is preferable to set it as 0.01-0.5 mass% among them. In this invention, it is especially preferable to set it as 0.1-0.35 mass% turned out to be the range of the compounding quantity which does not impair the effectiveness of cetyl pyridinium chloride more.

  In the composition for liquid oral cavity of the present invention, an oil-soluble component and a nonionic surfactant are further blended while blending cetylpyridinium chloride, and the blending amount of the nonionic surfactant is changed to the blending amount of the oil-soluble component. On the other hand, the blending ratio is in the range of 0.57 to 3.5. The blending ratio is preferably 0.67 to 1.0. The value obtained by subtracting the blending amount of the nonionic surfactant from the blending amount of the oil-soluble component is preferably −0.25 to 0.15, and preferably 0 to 0.1. This is more preferable because the retention of is increased. When it is smaller than the above range, the amount of adsorption of cetylpyridinium chloride on the teeth tends to decrease.

  Although a limited interpretation is not desired, when the blending ratio of the nonionic surfactant with respect to the blending amount of the oil-soluble component is smaller than the above range, the transparency of the composition becomes poor, and conversely, When it is larger than the range, there is a tendency that the amount of cetylpyridinium chloride adsorbed on the teeth decreases.

  Examples of the calcium salt used in the present invention include calcium gluconate, calcium lactate, calcium chloride, calcium acetate, calcium L-ascorbate, calcium pantothenate, calcium propionate, calcium nitrate and calcium carbonate. Of these, calcium gluconate, calcium lactate, calcium chloride, calcium acetate, calcium pantothenate, calcium propionate and calcium nitrate are preferred, calcium gluconate, calcium lactate, calcium chloride, calcium acetate and calcium nitrate are more preferred, and calcium gluconate Most preferred are calcium lactate and calcium chloride.

  It is preferable that the transparent liquid composition for oral cavity of the present invention does not contain ethyl alcohol as much as possible. Specifically, the blending amount of ethyl alcohol is preferably suppressed to less than 1% by mass, and most preferably no ethyl alcohol is blended.

  The liquid oral cavity composition of the present invention can be provided in the form of a liquid dentifrice, mouthwash, low viscosity gel, and the like. In addition to the components described above, the liquid oral composition can further contain the following suitable components according to the form of the composition within a range not impairing the effects of the present invention.

  For example, examples of the surfactant include amphoteric surfactants, cationic surfactants, and anionic surfactants in addition to the nonionic surfactants. Examples of zwitterionic surfactants include N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine and N-myristyldiethylglycine, N-alkyl-N-carboxymethylammonium betaine, and 2-alkyl-1hydroxyethylimidazoline betaine sodium. Can be mentioned. Examples of the cationic surfactant include alkyl trimethyl ammonium chloride, alkyl trimethyl ammonium bromide, and dialkyl dimethyl ammonium chloride. Examples of the anionic surfactant include sodium lauryl sulfate, sodium myristyl sulfate, sodium N-acyl sarcosine, sodium N-acyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, α -Sodium olefin sulfonate and the like. These surfactants can be blended alone or in combination of two or more. The compounding quantity is 0.01-1 mass% normally with respect to the composition whole quantity.

  As a flavoring agent, what is handled as a water-soluble fragrance | flavor other than said fragrance | flavor can be used.

  As the wetting agent, sorbit, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polypropylene glycol, polyethylene glycol and the like can be used alone or in combination of two or more. A compounding quantity is 3-20 mass% normally with respect to the composition whole quantity.

  Furthermore, sweetness such as saccharin sodium, acesulfame potassium, stevioside, glycyrrhizin, perilartin, thaumatin, asparatylphenylalanyl methyl ester, ρ-methoxycinnamic aldehyde, sucralose, palatinose, reduced palatinose, mannitol, xylitol, maltitol, lactitol An agent can be mix | blended 0.001-1 mass% with respect to the composition whole quantity.

  Examples of pH adjusters include citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, aspartic acid, succinic acid, glucuronic acid, fumaric acid, glutamic acid, adipic acid, and salts thereof, hydrochloric acid, sodium hydroxide , Potassium hydroxide, sodium silicate and the like. These components can be contained in the oral composition of the present invention alone or in combination of two or more. The pH of the oral composition of the present invention is not particularly limited as long as it can be used in the oral cavity, but is usually pH 3.0 to 10.5, preferably pH 5.5 to 8.0.

  In addition, the liquid oral composition of the present invention can contain a water-soluble medicinal component as the medicinal component in addition to the oil-soluble medicinal component. In addition to cetylpyridinium chloride as a water-soluble medicinal ingredient, for example, cationic fungicides such as chlorhexidine hydrochloride, chlorhexidine gluconate, benzethonium chloride and benzalkonium chloride; amphoteric fungicides such as dodecyldiaminoethylglycine; Enzymes such as nuclease, amylase, protease, mutanase, lysozyme, lytic enzyme (lytechenzyme); glycyrrhizinate such as dipotassium glycyrrhizinate as anti-inflammatory agent; tranexamic acid, epsilon aminocaproic acid as antiplasmin agent; ascorbine as bleeding ameliorating agent Acids, etc .; Allantoin, etc. as tissue repair agents; Others include plant extracts extracted with water-soluble solvents, chlorophyll, sodium chloride, caropeptide, zinc chloride, etc. It may be blended singly or in combination of two or more. The compounding quantity is 0.001-5 mass% normally with respect to the composition whole quantity.

  Further, the liquid oral composition of the present invention includes alkali metal alginates such as cationized hydroxyethyl cellulose and sodium alginate; propylene glycol alginate, xanthan gum, tragacanth gum, karaya gum, arabiya gum, carrageenan and the like. Gums: One or two or more kinds of binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, carboxymethylcellulose, and hydroxyethylcellulose can be blended. When blending these, the blending amount is usually about 0.001 to 1% by mass.

  In addition, the liquid oral composition of the present invention may contain an N-long chain acyl basic amino acid lower alkyl ester or a salt thereof. In particular, the basic amino acid moiety may be ornithine, lysine or arginine, which may be either optically active or racemic. The acyl group is a saturated or unsaturated fatty acid residue having 8 to 22 carbon atoms, and examples thereof include single fatty acid residues such as lauroyl group, myristyl group, palmitoyl group, stearoyl group, and coconut oil. Natural mixed fatty acid residues such as fatty acid residues and beef oil fatty acid residues may also be used. Examples of lower alkyl esters include methyl esters, ethyl esters, and propyl esters. As salts of these N-long chain acyl basic amino acid lower alkyl esters, inorganic acid salts such as hydrochloride and sulfate; glutamate, pyroglutamate, acetate, tartrate, citrate, fatty acid salt, Organic acid salts such as acidic amino acid salts are listed. In particular, glutamate, pyroglutamate, acetate, and citrate are preferable. Specific examples of N-long chain acyl basic amino acid lower alkyl esters or salts thereof include N-cocoyl-L-arginine ethyl ester / pyrrolidone carboxylate (CAE), N-lauryl-L-arginine ethyl ester, Examples include pyrrolidone carboxylate. The amount of N-long chain acyl basic amino acid lower alkyl ester or a salt thereof is preferably about 0.005 to 1% by mass based on the whole oral liquid preparation. Moreover, about 1/5 or more is preferable by weight ratio with respect to cetyl pyridinium chloride. The upper limit of the weight ratio in this case is not particularly limited, but is usually about 10 times.

Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples. In the following, “%” means “mass%” unless otherwise specified.

<Adsorption test of cetylpyridinium chloride on tooth surface>
As a model of tooth enamel, hydroxyapatite powder (BIO-RAD Lab. Hydroxyapatite Bio-Gel HTP Gel) (hereinafter abbreviated as HA) immersed in human saliva at 37 ° C. for 24 hours was used. By dipping in saliva, salivary mucoproteins and the like were adsorbed on the HA surface to approximate the actual state of tooth enamel wetted by saliva. Each sample shown in Table 1 was added to the saliva-treated HA and shaken at 37 ° C. for 15 minutes. Thereafter, the cetylpyridinium chloride finally rinsed with distilled water and adsorbed on HA was quantified using liquid chromatography, and the influence of the mixing ratio of the nonionic surfactant to the oil-soluble component was examined. In addition, the judgment criteria are as follows. Here, the unit of the adsorption amount of cetylpyridinium chloride is μg / HA 50 mg.

◎: Adsorption amount of cetylpyridinium chloride is 60 or more ○: Adsorption amount of cetylpyridinium chloride is 40 or more and less than 60 ×: Adsorption amount of cetylpyridinium chloride is less than 40

  In addition, the adsorption amount of cetylpyridinium chloride is preferably 40 or more, and a larger value is more preferable. Those having an adsorption amount of less than 40 are considered to be unable to exhibit a sufficient sterilizing effect and are not preferable.

<Appearance evaluation test>
As described above, after preparing each sample shown in Table 1, the transparency as a liquid preparation was examined visually. The judgment criteria were as follows. In addition, the numerical value of each component shown in Table 1 and Table 2 shows the mass%.

◎: colorless and transparent ○: slightly transparent ×: cloudy

  As shown in Tables 1 and 2, the ratio of the blending amount of the nonionic surfactant to the blending amount of the oil-soluble component is 0.57 to 3.5, and the blending amount of the oil-soluble component determines the nonionic surfactant. It was found that when the value obtained by subtracting the amount of was in the range of -0.25 to 0.15, the composition exhibited excellent transparency and retention of cetylpyridinium chloride on the hydroxyapatite surface.

  Hereinafter, although the prescription of the Example of the transparent liquid oral cavity composition which concerns on this invention is given, this invention is not limited to the following prescription. (A) and (B) described after the component name indicate that the component corresponds to the oil-soluble component (A) and the nonionic surfactant (B).

Formulation 1 Liquid Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
Calcium gluconate 1.0
Fragrance (A) 0.2
Methyl paraoxybenzoate (A) 0.1
Triclosan (A) 0.05
Polyoxyethylene (60) hydrogenated castor oil (B) 0.2
Glycerin 10.0
Propylene glycol 5.0
Saccharin sodium 0.01
N-cocoyl-L-arginine ethyl ester / pyrrolidone carboxylate 0.01
pH adjuster
Purified water balance
Total 100.0
B / A value is 0.57. The AB value is 0.15.

Formulation Example 2 Liquid Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
Calcium gluconate 1.5
l-Menthol (A) 0.1
Tocopherol acetate (A) 0.05
Methyl paraoxybenzoate (A) 0.2
Polyoxyethylene (60) hydrogenated castor oil (B) 0.3
Glycerin 10.0
Maltitol 0.5
Propylene glycol 5.0
N-cocoyl-L-arginine ethyl ester / pyrrolidone carboxylate 0.01
pH adjuster
Purified water balance
Total 100.0
The B / A value is 0.85. AB value is 0.05.

Formulation Example 3 Liquid Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
Calcium gluconate 1.5
l-Menthol (A) 0.15
Isopropylmethylphenol (A) 0.05
Methyl paraoxybenzoate (A) 0.1
Polyoxyethylene (60) hydrogenated castor oil (B) 0.25
Glycerin 13.0
Xylitol 1.0
Hydroxyethyl cellulose 0.2
pH adjuster
Purified water balance
Total 100.0
B / A value is 0.83. AB value is 0.05.

Formulation Example 4 Liquid Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.3
Calcium gluconate 1.5
l-Menthol (A) 0.05
Methyl paraoxybenzoate (A) 0.15
Polyoxyethylene (60) hydrogenated castor oil (B) 0.15
Glycerin 10.0
Reduced palatinose 1.0
pH adjuster
Purified water balance
Total 100.0
B / A value is 0.75. AB value is 0.05.

Formulation Example 5 Liquid Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
Calcium gluconate 1.5
l-Menthol (A) 0.05
Methyl paraoxybenzoate (A) 0.05
Polyoxyethylene (40) hydrogenated castor oil (B) 0.3
Glycerin 10.0
Propylene glycol 5.0
Saccharin sodium 0.01
N-cocoyl-L-arginine ethyl ester / pyrrolidone carboxylate 0.01
pH adjuster
Purified water balance
Total 100.0
B / A value is 3. The AB value is -0.2.

Formulation Example 6 Liquid Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
Calcium lactate 1.0
l-Menthol (A) 0.05
Tocopherol acetate (A) 0.01
Methyl paraoxybenzoate (A) 0.05
Polyoxyethylene (60) hydrogenated castor oil (B) 0.15
Glycerin 10.0
1,3-butylene glycol 2.0
Reduced palatinose 1.0
pH adjuster
Purified water balance
Total 100.0
B / A value is 1.36. The AB value is -0.04.

Formula 7 Liquid Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
Calcium lactate 1.0
l-Menthol (A) 0.05
Methyl paraoxybenzoate (A) 0.05
Polyoxyethylene (60) hydrogenated castor oil (B) 0.35
Glycerin 10.0
Propylene glycol 5.0
Saccharin sodium 0.01
N-cocoyl-L-arginine ethyl ester / pyrrolidone carboxylate 0.01
pH adjuster
Purified water balance
Total 100.0
B / A value is 3.5. The AB value is -0.25.

Formulation Example 8 Liquid Dentifrice

Ingredients Amount
Cetylpyridinium chloride 0.05
Calcium chloride 0.5
l-Menthol (A) 0.15
Triclosan (A) 0.05
Methyl paraoxybenzoate (A) 0.05
Polyoxyethylene (60) hydrogenated castor oil (B) 0.4
Glycerin 10.0
1,3 Butylene glycol 3.0
Saccharin sodium 0.01
pH adjuster
Purified water balance
Total 100.0
B / A value is 1.6. The AB value is -0.15.

Formulation Example 9 Mouthwash

Ingredients Amount
Cetylpyridinium chloride 0.05
Calcium pantothenate 1.0
Fragrance (A) 0.15
Tocopherol nicotinate (A) 0.05
Polyoxyethylene (60) hydrogenated castor oil (B) 0.3
Glycerin 10.0
Saccharin sodium 0.01
pH adjuster
Purified water balance
Total 100.0
B / A value is 1.5. The AB value is -0.1.

Example 10 Mouthwash

Ingredients Amount
Cetylpyridinium chloride 0.05
Calcium propionate 0.5
Oil-soluble daylily (A) 0.01
l-Menthol (A) 0.1
Methyl paraoxybenzoate (A) 0.1
Polyoxyethylene (60) hydrogenated castor oil (B) 0.3
Glycerin 10.0
Saccharin sodium 0.01
pH adjuster
Purified water balance
Total 100.0
B / A value is 1.42. The AB value is -0.09.

Claims (7)

  Calcium salt which is at least one selected from the group consisting of calcium gluconate, calcium lactate, calcium chloride, calcium acetate, calcium L-ascorbate, calcium pantothenate, calcium propionate, calcium nitrate and calcium carbonate, and cetyl chloride It contains pyridinium, an oil-soluble component and a nonionic surfactant, and the blending ratio of the nonionic surfactant to the oil-soluble component is 0.57 to 3.5, and the oil-soluble component (A) and the non-ionic surfactant The transparent liquid composition for oral cavity, wherein the difference (A)-(B) in the blending amount of the ionic surfactant (B) is -0.25 to 0.15.   The transparent liquid composition for oral cavity according to claim 1, wherein the oil-soluble component comprises an oil-soluble medicinal component and / or a fragrance.   The transparent liquid composition for oral cavity according to claim 2, containing 0.1 to 0.5% by mass of an oil-soluble component.   The oil-soluble medicinal component is at least one selected from the group consisting of triclosan, tocopherol acetate, β-glycyrrhetinic acid, p-hydroxybenzoic acid ester, isopropylmethylphenol, tocopherol nicotinate and oil-soluble plant extract The transparent liquid oral cavity composition according to any one of claims 2 and 3.   The transparent liquid oral composition according to any one of claims 1 to 4, comprising 0.01 to 1.0% by mass of cetylpyridinium chloride.   The transparent liquid oral composition according to any one of claims 1 to 5, wherein the nonionic surfactant is polyoxyethylene hydrogenated castor oil.   The transparent liquid composition for oral cavity according to any one of claims 1 to 6, wherein the amount of ethyl alcohol is less than 1% by mass.