JP2011115434A - Wear for preventing and treating artery disease and exercise training method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a technique to prevent and treat arterial diseases by a new approach different from conventional medication and lifestyle improvement. <P>SOLUTION: There is provided the wear for preventing and/or treating arterial diseases which is formed of a raw material having elasticity, covers one or more parts chosen from among the four limbs, the neck and the body by adhering to the skin surfaces of the parts, and gives a plurality of physical stimulations different in kind and/or size to the skin surfaces. The wear can improve arterial compliance by giving the physical stimulations to the skin surfaces. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a wear and an exercise training method used for prevention and / or treatment of arterial disease. Specifically, the present invention relates to a wear or the like that improves arterial compliance by applying physical stimulation to the skin surface.

  In general, lifestyle-related diseases such as obesity, hypertension, hyperglycemia, and hyperlipidemia are known as diseases caused by lifestyle habits such as high-calorie diet, drinking / smoking, lack of exercise, and stress. These lifestyle-related diseases are known as risk factors for arteriosclerosis, which is one of the main causes of cardiovascular diseases such as myocardial infarction and cerebral infarction, and have become a serious social problem. As for the symptoms of arteriosclerosis, no fundamental treatment has been established other than the improvement of dietary habits and the improvement of lifestyle habits by appropriate exercise.

  Recently, it has been confirmed that one of the causes of arteriosclerosis is associated with a decrease in the function of vascular endothelial cells. Vascular endothelial cells protect the vascular endothelium by inhibiting monocyte adhesion and inhibiting thrombus formation by regulating blood coagulation by releasing blood coagulation inhibitor in addition to regulating vasodilation by releasing endothelium-derived relaxing factor, etc. Suppress.

  However, when damage to the vascular endothelium occurs due to lifestyle-related diseases such as hypertension, a decrease in vascular diastolic function due to a decrease in the release of endothelium-derived relaxing factor, and a decrease in endothelial function due to a decrease in blood coagulation suppression function due to inflammation, etc. The decrease in vascular endothelial function exacerbates arteriosclerosis, causes cardiovascular diseases such as myocardial infarction and cerebral infarction, and worsens symptoms. Currently, there is an urgent need to develop preventive and therapeutic agents for the deterioration of vascular endothelial function caused by lifestyle-related diseases such as hypertension.

  Conventionally, it is known that an extract derived from a natural component has an action of promoting the release of nitric oxide (NO), which is one of endothelium-derived relaxing factors, in the regulation of vasodilation, which is one of vascular endothelial functions. ing. Patent Document 1 discloses a vascular endothelial function improving drug containing polyphenols derived from citrus fruits as an active ingredient. Patent Document 2 describes a composition for improving vascular flexibility, which contains isohumulones derived from hops as active ingredients.

In general, nitric oxide is synthesized from arginine by nitric oxide synthase (NOS) in vivo, and the activity of nitric oxide synthase when shear stress (resistance force that endothelial cells receive due to blood flow and blood viscosity) works. Is known to be enhanced. Nitric oxide has a vascular smooth muscle relaxing action, a platelet aggregation inhibitory action by producing prostaglandin I ₂ (PGI ₂ ), and a production inhibitory action of a cell adhesion factor that causes thrombus. It is known to exert an improving action. Nitric oxide is expected to exert an anti-arteriosclerotic effect by these actions.

JP 2009-13080 A International Publication No. 2004/064818

  For arteriosclerosis, pharmacotherapy as disclosed in Patent Documents 1 and 2 has been studied, but there are fundamental countermeasures other than improving dietary habits and lifestyle habits by appropriate exercise. There is no current situation, and there is an urgent need to develop a technique for preventing or treating deterioration of vascular endothelial function.

  Therefore, the main object of the present invention is to provide a technique for preventing and treating arteriosclerosis by a new approach different from conventional drug therapy and lifestyle improvement.

In order to solve the above problems, the present invention comprises a stretchable material, and covers one or more parts selected from the limbs, neck and torso in close contact with the skin surface of the part, Provided is a wear for preventing and / or treating arterial disease, which applies a plurality of physical stimuli of different types and / or sizes to the skin surface.
By applying physical stimulation to the skin surface, blood flow velocity, gradient of blood flow velocity, blood vessel diameter, etc. change, shear stress is applied to vascular endothelial cells, and nitric oxide (NO) of vascular endothelial cells due to shear stress ), And the arterial stiffness can be improved by the effect of relaxing vascular smooth muscle and inhibiting platelet aggregation by NO.
The wear covers at least four limbs and is one or more selected from the group consisting of a dorsal artery, plantar artery, anterior tibial artery, posterior tibial artery, radial artery, popliteal artery, femoral artery, radial artery and brachial artery The skin surface located on the muscular arteries can be applied with the physical stimulus, and at least the ankle and calf are covered, the dorsal artery, the plantar artery, the anterior tibial artery, the posterior tibial artery, the radius Preferably, the physical stimulation is applied to a skin surface located on one or more muscular arteries selected from the group consisting of arteries and popliteal arteries.
In this wear, a compression stimulus can be adopted as the physical stimulus. In this case, the wear may be configured to cover at least the ankle and the calf, and the pressure applied when wearing the area covering the ankle may be greater than the pressure applied when wearing the area covering the calf. It can comprise so that it may be provided with the compression pressure distribution in which the compression pressure at the time of wearing becomes small stepwise or gradually toward a calf. Under the present circumstances, it is preferable that the pressure pressure at the time of wearing of the area | region which covers an ankle is 18-52 hPa, and the pressure pressure at the time of wearing of the area | region which covers a calf is 9-40 hPa.
The present invention also provides an exercise training method including a procedure for applying a plurality of physical stimuli of different types and / or sizes to a muscular artery located under the skin surface through the skin surface. .

  In the present invention, the concept of “applying physical stimulation to the skin surface” includes not only applying physical (energy) stimulation such as compression stimulation to the skin contact surface, but also epidermis located deeper than the surface, It is also intended to include physical stimulation of the dermis and subcutaneous tissue. In addition, the concept includes applying physical stimulation to the wound area formed in the skin. Therefore, “applying physical stimulation to the skin surface” means that a needle-like object provided on the skin contact surface of the wear is stabbed into the skin, and electrical stimulation is applied to the dermis or subcutaneous tissue. Covering the wound periphery and applying a compression stimulus or the like to the wound part can also be included.

  According to the present invention, a technique for preventing and treating arteriosclerosis is provided by a new approach different from conventional drug therapy and lifestyle improvement.

It is a figure explaining suitable embodiment (band form) of the wear concerning the present invention. It is a figure explaining suitable embodiment (sleeve-like form) of the wear concerning the present invention. It is a figure explaining suitable embodiment (shirt-like form) of the wear concerning the present invention. (A) is a front view, (B) is a rear view. It is a figure explaining suitable embodiment (sock-like form) of the wear concerning the present invention. (A) is a front view, (B) is a rear view. It is a figure explaining suitable embodiment (stockings form) of the wear concerning the present invention. (A) is a front view, (B) is a rear view. It is a figure explaining suitable embodiment (tights form) of the wear concerning the present invention. (A) is a front view, (B) is a rear view. It is a figure explaining suitable embodiment (pants-like form) of the wear concerning the present invention.

  In assessing arterial compliance, i.e., elasticity and extensibility of arteries, based on measurement of pulse wave velocity, the present inventors applied arterial stiffness to the skin surface to provide stiffness (hardness) of the arteries. ) Was discovered. Based on this new knowledge, the wear for arterial disease prevention and / or treatment (hereinafter simply referred to as “wear”) and an exercise training method according to the present invention for applying physical stimulation to the skin surface were completed. . “Pulse wave propagation speed” means the speed at which a pulse wave propagates through an artery, and can be measured using a general-purpose inspection apparatus (see Examples described later).

  The reason why the stiffness of the artery can be improved by applying a physical stimulus to the skin surface is that the present inventors have changed the blood flow velocity, the gradient of the blood flow velocity, the blood vessel diameter, etc. It is considered that shear stress is applied to the cells. When shear stress is applied to vascular endothelial cells, the production of nitric oxide (NO) in vascular endothelial cells is promoted, and the arterial stiffness is improved by the relaxing action of vascular smooth muscle and the inhibition of platelet aggregation by NO. It is done.

  DESCRIPTION OF EMBODIMENTS Hereinafter, preferred embodiments for carrying out the present invention will be described with reference to the drawings. In addition, embodiment described below shows an example of typical embodiment of this invention, and, thereby, the range of this invention is not interpreted narrowly.

1. Wear for Arterial Disease Prevention / Treatment (1) Form The wear according to the present invention includes a stretchable material, and one or more parts selected from the extremities, the neck, and the torso are used as the skin of the part. The surface is coated in close contact with the skin, and a plurality of physical stimuli of different types and / or sizes are applied to the skin surface.

  The form of the wear according to the present invention is not particularly limited as long as it can cover one or more parts selected from the limbs, the neck, and the torso in close contact with the skin surface. It is assumed that it is a clothing-like form that can be worn or not (a specific form will be described later). By adopting a clothing form, adjustment and change of the wearing position, long-term use, repeated use, etc. can be performed easily and comfortably.

(2) Material The wear according to the present invention is made of at least a part of a stretchable material in order to cover the limbs and the like in close contact with the skin surface. By forming a stretchable material alone or in combination of a stretchable material and a non-stretchable material, adhesion to the skin surface can be improved and the movement of the wearer's muscles can be prevented.

  As a material having elasticity, a knitted fabric, a woven fabric, a nonwoven fabric, a foamed sheet, a synthetic resin sheet (film), or the like can be used. The wear according to the present invention is formed by knitting, weaving, sewing, laminating, adhering, or welding these materials alone or in combination as appropriate.

  The yarn constituting the knitted fabric may be either natural fiber or chemical fiber, such as polyamide fiber, polyester fiber, acrylic fiber, cellulosic fiber (cotton, rayon, polynosic, lyocell, etc.), polyurethane fiber, A yarn using a polyolefin fiber (polyethylene, polypropylene, etc.), an acetate fiber, a polyvinylidene chloride fiber, a polyvinyl chloride fiber or the like alone or a mixture of these fibers can be used. As the type of yarn, monofilament, multifilament, twisted yarn, covered yarn, core yarn and the like can be used, and those subjected to stretch processing or bulk processing may be used.

  In addition, when forming the wear by knitting, various knitting structures such as warp knitting or weft knitting can be used, for example, flat knitted fabric, rubber knitted (rib knitted) fabric, pearl knitted fabric, tuck knitted fabric, circular knitted fabric, horizontal knitted fabric, Knitted fabrics, tricot fabrics, raschel fabrics, pile knitted fabrics, spliced yarn knitted fabrics and the like can be used.

  When the physical stimulus applied to the skin surface is a compression stimulus, the elasticity (elongation) characteristics of the stretchable material are taken into account by taking into account changes in the compression pressure caused by changes in the circumference of the extremities due to skeletal muscle contraction, etc. The relationship with the tension can be adjusted. For example, by adjusting the relationship between the elastic properties of the stretchable material and the tension, it is possible to appropriately arrange the magnitude of the pressure fluctuation according to the stimulation site.

(3) Physical Stimulation The wear according to the present invention can provide a plurality of partitioned areas on the skin contact surface in order to impart a plurality of physical stimuli of different types and / or sizes to the skin surface. Applying physical stimuli to the skin surface, especially applying multiple physical stimuli of different types and / or sizes, changes blood flow velocity, gradient of blood flow velocity, blood vessel diameter, etc. Shear stress can be applied to the endothelial cells. Shear stress promotes the production of nitric oxide (NO) in vascular endothelial cells, improves the stiffness of arteries and suppresses arteriosclerosis by relaxing vascular smooth muscle and inhibiting platelet aggregation. can do.

  Types of physical stimulation include compression stimulation, friction stimulation, electrical stimulation, thermal stimulation (warm or cold stimulation), magnetic stimulation, and light stimulation. These physical stimuli are applied to the skin surface alone or in combination as appropriate. The physical stimulation is preferably compression stimulation or friction stimulation, and compression stimulation is particularly preferable.

(3-1) Compression stimulus As a method of applying a compression stimulus, a method of adjusting the extensibility and stretchability of the material constituting the region covering the skin surface to which the stimulus is applied, a method of adjusting the peripheral size of the region, Examples thereof include a method of arranging convex portions such as pads in the region.

  The stretchability and stretchability of the material can be performed by changing the structure constituting the material, adjusting the yarn density, or changing the yarn type. The stretchability and stretchability can be adjusted, for example, by inserting an elastic yarn such as a covered yarn of polyurethane fiber or rubber yarn into a knitted structure or by adjusting the number of inserted elastic yarns.

  As sleeve-like, sock-like, stocking-like, tights-like wear that can give compression stimulation for limbs, for example, using a circular knitting machine, polyurethane yarn, rubber yarn, etc. as ground yarn such as polyamide yarn or cotton yarn Can be suitably formed by a flat knitted structure or a rubber knitted structure into which the elastic yarn is inserted.

  It is preferable to apply the compression stimulus so that different pressures are applied to various portions of the skin surface covered with the wear. The compression pressures of different sizes are, for example, by increasing the compression pressure of a predetermined area of the wear compared to other areas, or by changing the compression pressure between adjacent areas stepwise or gradually, Can be applied to various places on the skin surface. By providing such a pressure distribution, the blood flow velocity, the gradient of the blood flow velocity, the blood vessel diameter, etc. can be changed more effectively, and the vascular endothelial cells are oxidized by applying shear stress to the vascular endothelial cells. Nitrogen (NO) production can be promoted.

  The skin surface to which the compression stimulus is applied is preferably a site where muscular arteries having a blood vessel diameter of about 1 mm or more are distributed from the viewpoint of easy action on the blood flow and blood vessel diameter of the stimulus and ease of introduction of the stimulus, In particular, it is preferable to compress the site through which the muscular artery distributed in the extremities runs.

  Examples of such muscular arteries include the dorsal artery, plantar artery, anterior tibial artery, posterior tibial artery, radial artery, popliteal artery, femoral artery, radial artery, and brachial artery. Preferably, a compression stimulus is applied to the skin surface of the limb located on at least one selected muscular artery. Further, compression stimulation is applied to the skin surface of the ankle and calf located on at least one muscular artery selected from the group consisting of the dorsal artery, plantar artery, anterior tibial artery, posterior tibial artery, radial artery, and popliteal artery. It is particularly preferred to add.

  Especially on the muscular arteries, such as the pressure distribution, which gradually or gradually decreases the pressure from the peripheral part of the extremity toward the center of the trunk (trunk), such as from the ankle to the calf, or from the ankle to the thigh. An embodiment in which a compression pressure distribution with a difference in height is provided is preferable.

  The compression pressure applied to the skin surface is preferably 18 to 52 hPa, more preferably 25 to 45 hPa in terms of the compression pressure when wearing the wear, in the region covering the ankle. Moreover, in the area | region which coat | covers a calf, 9-40 hPa is preferable and 18-35 hPa is further more preferable.

  The measurement of the compression pressure when wearing the wear can be performed using a conventionally known pressure measuring device MST (for example, Salzmann (manufactured by AG)). Specifically, a probe of a measuring instrument is placed between the wear and the measurement site (skin surface) with the wear attached, and the compression pressure measured at that time is calculated as the wearing pressure. Note that the pressure at the ankle is measured at the minimum leg and the pressure at the calf is measured at the maximum leg.

  In order to give an appropriate compression stimulus to the skin surface, an indicator function that can confirm and adjust the compression pressure when wearing the wear may be provided. Specifically, a figure or scale whose shape changes depending on the degree of expansion can be provided on the material constituting the wear by printing, embroidery, or the like, and used as a compression pressure indicator. In addition, a fixing means such as a belt or a hook-and-loop fastener for fixing the wear to a predetermined part may be provided with a numerical value or a scale indicating the degree of tightening at the time of wearing to provide a compression pressure indicator. Further, a pressure sensor or the like may be installed in a region to which a compression stimulus is applied.

(3-2) Friction stimulation As a method of applying friction stimulation to the skin, a method of forming a skin surface to which irritation is applied and a region covering the skin surface to which irritation is not applied by using different materials and imparting different friction characteristics. Is mentioned.

  For example, changing the frictional properties can change the surface roughness of the fabric by changing the thickness, material, and form of the yarn, or by changing the surface roughness depending on the type of fabric (knitted fabric, woven fabric, non-woven fabric, etc.). Or a method of forming irregularities on the surface by changing the structure such as the weaving pattern and density.

  In addition, a method of imparting a friction characteristic that easily recognizes a tactile sensation can be used by applying paint and / or powder by spraying a region where the frictional stimulus of the wear is imparted. If application by jetting is used, a frictional stimulus imparting region having a predetermined shape and position can be easily and accurately formed. Specifically, (1) resin characteristics or powder characteristics of the paint or powder itself to be applied, (2) uneven structure of the applied paint or powder formed on the surface of the cloth, and (3) the applied removal. Friction characteristics can be easily adjusted by the concavo-convex structure formed on the surface of the fabric by the corrosive agent.

  As for the coating form of paint and powder by spraying, in addition to the form that is applied to the cloth on the skin contact surface side of the wear, dot pattern, lattice pattern, mesh pattern, striped pattern, wavy line pattern, zigzag line pattern, spiral pattern, etc. The form which apply | coats to arbitrary pattern patterns of (1) can be used.

  As a spray coating method, it is particularly preferable to use an ink jet method. According to the ink jet method, an original drawing of a coating pattern to be formed is subjected to image processing by a computer, and the result is printed by the ink jet method, so that various patterns can be produced easily and at low cost. The friction characteristics can be arbitrarily changed depending on the type of paint used and its application pattern.

  The friction characteristics can also be changed by applying and spraying synthetic resin, oil, gel, adhesive, inorganic particles, etc. on the surface of the wear on the skin contact side by an application method other than the above-described spray application.

  The skin surface to which the frictional stimulus is applied can be the same as the compression stimulus. The frictional stimulus is preferably used in combination with a compression stimulus.

(3-3) Electrical stimulation As a method of applying electrical stimulation to the skin, a flexible and conductive material may be used as a part of the material constituting the region covering the skin surface to which stimulation is applied, and a power source may be connected. . Specifically, for example, a conductive gel having adhesiveness, a substrate formed by printing or coating a conductive material in a predetermined pattern (circuit), a conductive resin film, a thread or cloth made of conductive fibers, a metal foil A mode in which flat materials such as these are arranged on the skin contact surface of the wear alone or in appropriate combination can be used.

  The skin surface to which electrical stimulation is applied can be similar to compression stimulation. The electrical stimulation is preferably used in combination with the compression stimulation.

(3-4) Thermal stimulation As a method of applying thermal stimulation (thermal stimulation) to the skin, for example, a heat-generating material is used as a part of the material constituting the region covering the skin surface to which stimulation is applied, or a power source is used. A heat-generating resistor or other thermoelectric element connected to the surface may be provided on the skin contact surface of the wear.

  In addition, as a method of applying thermal stimulation (cold stimulation) to the skin, for example, an endothermic material is used as a part of the material constituting the region covering the skin surface to which irritation is applied, or a cooling pad is used on the skin of the wear What is necessary is just to provide in a contact surface. The cooling pad is preferably composed of, for example, a liquid and a liquid-holding base material that holds the liquid, and is obtained by absorbing and holding a liquid such as water or oil in an absorbent fiber or absorbent open-cell foam. A pad or a cooling pad obtained by holding a liquid in a liquid-impermeable bag can be used.

  The skin surface to which a thermal stimulus is applied can be similar to a compression stimulus. Moreover, it is preferable to use thermal stimulation together with compression stimulation.

(3-5) Magnetic Stimulation As a method of applying magnetic stimulation to the skin, for example, a method of providing a coil or the like for generating a magnetic field in a region covering the skin surface to which stimulation is applied and connecting a power source can be employed.

  The skin surface to which a magnetic stimulus is applied can be similar to a compression stimulus. Moreover, it is preferable to use magnetic stimulation together with compression stimulation.

(3-6) Light Stimulation As a method of applying light stimulation to the skin, for example, a method of providing a light emitting element in a region covering the skin surface to which stimulation is applied and connecting a power source can be employed.

  The skin surface to which the light stimulus is applied can be the same as the pressure stimulus. The light stimulus is preferably used in combination with a compression stimulus.

2. Preferred Embodiment of Wear for Arterial Disease Prevention / Treatment FIGS. 1 to 7 show a specific embodiment of the wear according to the present invention. The wear according to the present invention has a plurality of partitioned regions on the skin contact surface in order to apply a plurality of physical stimuli of different types and / or sizes to the skin surface. In the figure, regions indicated by different patterns represent regions to which physical stimuli of different types and / or sizes are applied, and regions indicated by the same pattern represent regions to which the same physical stimuli are applied.

  Hereinafter, an embodiment of wear when a compression stimulus is used as a physical stimulus will be described with reference to FIGS.

(1) Belt-like / sleeve-like wear FIG. 1 shows wear formed in a belt shape covering the extremities, neck, and trunk (chest or abdomen). The belt-like wear shown in FIG. 1 has convex pads having three kinds of hardness arranged at two places on the left and right sides, and is wound around a target portion and attached by engaging a surface fastener provided at an end portion. Thus, a predetermined compression stimulus by the convex pad can be applied to the target site. FIG. 2 shows the wear formed in a sleeve shape covering the extremities, the neck, and the trunk. The wear shown in FIG. 2 (A) is particularly used for the upper limbs and the lower leg, and the wear shown in (B) is used for the thigh. These wears are provided with regions in which the compression pressure changes stepwise or gradually.

(2) Shirt-like Wear FIG. 3 is a shirt-like wear that can apply compression stimuli of different sizes to the skin surface located on the radial artery and brachial artery. The areas covering the forearm and the upper arm are formed of different materials and stretchable fabrics so as to apply a pressure greater than that of the brachial artery on the radial artery.

(3) Socks-like wear FIG. 4 is a high-sock-like wear that applies compression pressures of different sizes to the skin surface located on the dorsal artery, plantar artery, anterior tibial artery, posterior tibial artery, and radial artery. It is something that can be done. The stretchability of the material constituting the fabric is changed for each region so that the compression pressure gradually decreases from the ankle to the calf.

(4) Stocking-like wear FIG. 5 is an over knee sock or stocking-like wear, with different sizes on the skin surface located on the dorsal artery, plantar artery, anterior tibial artery, posterior tibial artery, radial artery, popliteal artery This is the pressure that can be applied. The stretchability of the material constituting the fabric is changed for each region so that the compression pressure gradually decreases from the ankle to the thigh.

(5) Tights-like wear FIG. 6 shows tights-like wears with different sizes on the skin surface located on the dorsal artery, plantar artery, anterior tibial artery, posterior tibial artery, radial artery, popliteal artery, and femoral artery. This is the pressure that can be applied. The stretchability of the material constituting the fabric is changed for each region so that the compression pressure gradually decreases from the ankle to the thigh.

(6) Pant-like wear FIG. 7 is a pant-like wear in which (A) covers the top of the knee and (B) covers the bottom of the knee. Skin located on the popliteal artery and the femoral artery Different pressures can be applied to the surface. The compression pressure distribution can be configured similarly to the wear shown in FIG.

  Of the embodiments described above, the sock shape, the high sock shape (FIG. 4), and the stocking shape (FIG. 4) are easy to mount, less uncomfortable at the time of mounting, and easily exhibit the effect of improving the stiffness of the artery. 5), tights (FIG. 6), pants (FIG. 7), etc. are particularly preferred.

3. Exercise Training Method Next, the exercise training method according to the present invention will be described. This exercise training method includes a procedure of applying a plurality of physical stimuli of different types and / or sizes to a muscular artery located below the skin surface through the skin surface.

  In recent years, it has been reported that when anaerobic exercise such as strength training is continued, arterial stiffness is increased and the risk of arteriosclerosis is increased. On the other hand, it has also been revealed that arterial compliance is improved by performing aerobic exercise. However, in order to improve health, it is important to improve not only aerobic exercise but also anaerobic exercise as appropriate to improve muscle strength and improve physical strength in a balanced manner.

  According to the method of the present invention, in anaerobic exercise training in which instantaneous force such as muscular strength training or short-distance running is required, exercise compliance of arterial compliance is utilized by utilizing the aforementioned NO production promoting action of vascular endothelial cells. It is thought that improvement can be aimed at. Further, not only during exercise training, but also during warm-up before exercise training and during cool-down after exercise training, arterial compliance can be improved.

  Specifically, the exercise training method according to the present invention can be performed using, for example, the wear according to the present invention described above. First, wear the clothing in close contact with the skin surface. The part to be worn is not particularly limited as long as it is a part of the limb or the like where the muscular artery is present as described above, but preferably the dorsal artery, plantar artery, anterior tibial artery, posterior tibial artery, radial artery, and knee It is the lower limb portion where the foveal artery is present, and it is more preferable to wear the calf portion from the ankle portion. Then, while wearing the wear, warm-up is performed before exercise training, followed by exercise training, and further cool-down is performed after training.

  By performing exercise training in this manner, a plurality of physical stimuli of different types and / or sizes are applied to the muscular arteries located below the skin surface through the skin surface. The diameter changes. As a result, shear stress is applied to vascular endothelial cells, and nitric oxide production is promoted in vascular endothelial cells, and an increase in arterial stiffness due to training is suppressed during exercise training and before and after training to improve arterial compliance. It is considered possible. In particular, when anaerobic exercise training such as strength training is performed, it is preferable to train by wearing the wear of the present invention that can apply compression stimulation, and by training while applying compression stimulation in this way, This reduces the amount of wasted motion of joints and joints and enables efficient training.

<Example 1>
In this example, high socks-like wear (see FIG. 4) was knitted. Flat knitting was adopted from the ankle to the calf. For the yarns that form flat knitted stitches, elastic yarns in which polyurethane elastic yarns are single-covered with wooly nylon yarns, and blended yarns made of cotton and polyester (mixed yarns of 50% cotton and 50% polyester) are used. Then, an elastic yarn in which a polyurethane elastic yarn was double-covered with a nylon yarn was used as a yarn to be inserted into the stitch from the lateral direction. The wear was formed so that the width of the outer shape from the ankle to the calf gradually increased, and the outer edge on the calf side from the ankle to the calf was curved.

  The pressure distribution at the time of wearing of the obtained wear has a pressure distribution in which the pressure decreases gradually from the ankle to the calf, the pressure at the ankle is 33.0 hPa, and the pressure at the calf is 24.3 hPa. (See “Table 1”). The measurement of the compression pressure was performed in a state in which the wear was mounted on a foot with a circumference of 21 cm at the ankle, 35 cm at the calf, and 46.5 cm at the center of the thigh.

<Examples 2 to 5>
In Examples 2 to 5, the high socks-like wear created in Example 1 was knitted with a changed pressure distribution. Flat knitting was adopted from the ankle to the calf. As the yarn constituting the flat knitting stitch, a wooly nylon yarn was used, and an elastic yarn in which a polyurethane elastic yarn was double-covered with a nylon yarn was used as a yarn to be inserted into the stitch from the lateral direction. As in Example 1, the wear was formed such that the width of the outer shape from the ankle to the calf gradually increased, and the outer edge on the calf side from the ankle to the calf was curved.

  The pressure distribution at the time of wearing of the obtained wear had a pressure distribution in which the pressure gradually decreased from the ankle to the calf. The measurement results of the compression pressure at the ankle and calf in each wear are shown in “Table 1”.

<Test Example 1>
About the wear created in Examples 1-5, the influence which it has on arterial compliance was examined.

  The arterial compliance was evaluated using the brachial-ankle pulse wave velocity (baPWV) as an index. The measurement of baPWV was performed in the supine position using a blood pressure pulse wave test device (BP-203RPEIII, OMRON Colin). In addition, the blood pressure of the upper arm was also recorded.

  The baPWV and blood pressure measurements were performed in the two test subject groups shown in “Table 1” under wear wearing conditions and non-wearing conditions, and the results were compared. The measurement results are shown in “Table 1”.

  The baPWV generally indicates that the smaller the value, the higher the arterial blood vessel flexibility. As shown in “Table 1”, baPWV was able to be reduced in all test groups under the wear wearing condition as compared with the non-wearing condition.

  From the results of Test Example 1, it became clear that the arterial stiffness can be improved by the wear according to the present invention. This result strongly suggests that the wear according to the present invention is effective for the prevention and treatment of arterial diseases such as arteriosclerosis, myocardial infarction, and cerebral infarction.

  According to the wear according to the present invention, the stiffness of the artery can be improved by a simple method of wearing the wear compared to conventional methods such as drug therapy and lifestyle improvement. Therefore, the wear according to the present invention can be suitably used for preventing or treating arteriosclerosis, myocardial infarction, cerebral infarction, etc. in combination with or in place of the conventional method to suppress arteriosclerosis. .

Claims (8)

One or more parts selected from limbs, neck and torso are covered and covered with the skin surface of the part, including a stretchable material,
A wear for preventing and / or treating arterial disease, which imparts a plurality of physical stimuli of different types and / or sizes to the skin surface. Covering at least the limbs,
Skin surface located on one or more muscular arteries selected from the group consisting of ankle dorsal artery, plantar artery, anterior tibial artery, posterior tibial artery, radial artery, popliteal artery, femoral artery, radial artery and brachial artery The ware according to claim 1, wherein the physical stimulus is applied. Covering at least the ankle and calf,
The physical stimulation is applied to the skin surface located on one or more muscular arteries selected from the group consisting of the dorsal artery, plantar artery, anterior tibial artery, posterior tibial artery, radial artery and popliteal artery The wear according to claim 2.   The wear according to any one of claims 1 to 3, wherein the physical stimulus is a compression stimulus. Covering at least the ankle and calf,
The wear according to claim 4, wherein the pressure applied when wearing the area covering the ankle is made larger than the pressure applied when wearing the area covering the calf.   The garment according to claim 5, further comprising a pressure distribution in which the pressure when worn from the ankle toward the calf is gradually or gradually reduced.   The wear according to claim 5 or 6, wherein the compression pressure when wearing in the region covering the ankle is 18 to 52 hPa, and the compression pressure when wearing in the region covering the calf is 9 to 40 hPa.   An exercise training method comprising a step of applying a plurality of physical stimuli of different types and / or sizes to a muscular artery located under the skin surface through the skin surface.

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