JP2011110233A - Keratin peeling adhesive composition and keratin peeling adhesive sheet - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a keratin peeling adhesive composition which prepares an adhesive layer with an excellent keratin peeling capability; and a keratin peeling adhesive sheet which is excellent in keratin peeling capability. <P>SOLUTION: The keratin peeling adhesive composition includes an oil-and-fat absorptive material and an adhesive ingredient. The keratin peeling adhesive sheet has the adhesive layer prepared from the keratin peeling adhesive composition. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a keratin exfoliating pressure-sensitive adhesive composition and a keratin exfoliating pressure-sensitive adhesive sheet that contain an oil and fat absorbent and an adhesive component and are excellent in exfoliating ability.

The stratum corneum in the outermost layer of the skin is an interface that separates the inside of the living body from the outside world, and has a barrier function that prevents biological components from leaking into the outside world and prevents harmful components from entering the living body.
As described above, the keratin has an important function for the living body.For example, an active ingredient such as a drug or a vaccine is administered into the living body by percutaneous absorption, or a suction leachate is applied from the skin for the purpose of clinical examination or the like. It may be necessary to remove the stratum corneum during vacuum suction.

Conventionally, as a method for removing the keratin, for example, a method of removing the keratin by sticking an adhesive tape (adhesive sheet for exfoliating keratin) on the skin surface and peeling it after a certain time is known (Patent Document) 1-6 etc.).
However, the conventional adhesive tape (adhesive sheet for exfoliating keratin) may have insufficient keratin exfoliation ability when the sebum secretion amount is large. Sebum is secreted in different amounts depending on factors such as individual differences and seasonal differences, but it is possible to reduce the effects of these factors, and there is a need for the development of an adhesive sheet for exfoliating keratin that has better exfoliating ability. Is the current situation.

JP-A-5-123326 JP-A-3-151951 JP 2007-289672 A JP 2008-201698 A JP 2009-102304 A JP 2009-29742 A

  This invention is made | formed in view of an above-described situation, The subject is providing the adhesive composition for exfoliation and the exfoliation adhesive sheet which are excellent in exfoliation ability.

  As a result of intensive studies to solve the above problems, the inventors of the present invention have a stratum corneum peeling pressure-sensitive adhesive composition containing a pressure-sensitive adhesive component. The present inventors have found that an exfoliated pressure-sensitive adhesive sheet can be obtained, and have completed the present invention.

Thus, according to the first aspect of the present invention, the following adhesive compositions for exfoliating (1) to (5) are provided.
(1) A pressure-sensitive adhesive composition for exfoliating keratin containing an oil and fat absorbent and an adhesive component.
(2) The stratum corneum according to (1), wherein the oil and fat absorbent is made of at least one selected from the group consisting of inorganic materials, resin materials, organic-inorganic hybrid materials, charcoal and silk. Peeling adhesive composition for peeling.
(3) The keratin exfoliation according to (1) or (2), wherein the oil absorption amount of the oil and fat absorbent material measured in accordance with JIS K 5101-13-1 is 50 ml / 100 g or more. Pressure-sensitive adhesive composition.
(4) The oil and fat absorbing material is fine particles having oil and fat absorbing ability, and an average particle diameter measured according to JIS Z8825-1 is 1 to 100 μm (1) to ( The adhesive composition for exfoliating skin according to any one of 3).
(5) The keratin exfoliation according to any one of (1) to (4), wherein the content of the oil and fat absorbent is 1 to 50% by mass with respect to the entire pressure-sensitive adhesive composition for exfoliation. Pressure-sensitive adhesive composition.

According to 2nd of this invention, the adhesive sheet for exfoliation of the following (6) is provided.
(6) A stratum corneum peeling pressure-sensitive adhesive sheet having a pressure-sensitive adhesive layer comprising the stratum corneum peeling pressure-sensitive adhesive composition according to any one of (1) to (5).

The pressure-sensitive adhesive composition for exfoliating skin of the present invention is useful as a material for forming a pressure-sensitive adhesive layer that is extremely excellent in exfoliating ability.
The pressure-sensitive adhesive sheet for exfoliation of the present invention has a pressure-sensitive adhesive layer formed from the pressure-sensitive adhesive composition for exfoliation of the present invention, and is extremely excellent in the ability to exfoliate keratin.

  Hereinafter, the present invention will be described in detail by classifying it into 1) an exfoliating pressure-sensitive adhesive composition and 2) an exfoliating pressure-sensitive adhesive sheet.

1) Keratin peeling pressure-sensitive adhesive composition The stratum corneum peeling pressure-sensitive adhesive composition of the present invention is characterized by containing an oil and fat absorbent and an adhesive component.
The oil and fat absorbing material used in the present invention is not particularly limited as long as it is made of a material that is safe for human skin and has a property of absorbing sebum existing on the skin. Especially, it is preferable to consist of at least 1 type chosen from the group which consists of an inorganic material, a resin material, an organic inorganic hybrid material, charcoal, and silk.

  Inorganic materials include zeolite, silica, calcium, bentonite, hectorite, montmorillonite, smectite, kaolinite, halosite, diatomaceous earth, magnesium silicate / aluminum, magnesium silicate / sodium, kaolin, mica, talc, calcium carbonate , Barley stone, anhydrous silicic acid and the like. Also, for example, a surface of silica fine particles or the like coated with calcium or the like can be used.

  Resin-based materials include urethane resin; polyamide resin; nylon resin; cross-linked polyalkylstyrene resin; polymethyl methacrylate, polyethyl methacrylate, polymethyl methacrylate / ethylene glycol dimethacrylate copolymer, polyallyl methacrylate / ethylene glycol dimethacrylate copolymer, ethylene Acrylic resins such as glycol dimethacrylate / lauryl methacrylate copolymer; cellulose; and the like.

  Examples of the organic-inorganic hybrid material include compounds in which a hydrocarbon group such as an octadecyl group is bonded to the surface of silica or the like.

These fat and oil absorbing materials can be used alone or in combination of two or more.
Among these, zeolite, silica, urethane resin, charcoal, silk, and silica fine particles whose surface is modified with an organic group (for example, silica fine particles having an octadecyl group bonded to the surface) are preferable.

The oil and fat absorbent used in the present invention is preferably fine particles.
The shape of the fine particles is not particularly limited, and may be any shape such as a spherical shape, a rod shape, a plate shape, or a disk shape.
The average particle diameter of the fine particles measured according to JIS Z8825-1 is preferably 1 to 100 μm, and more preferably 5 to 50 μm. By using fine particles of such a size, the absorbability of sebum can be further increased.

  The oil-absorbing material used in the present invention has an oil absorption measured in accordance with JIS K5101-13-1 and is preferably 50 ml / 100 g or more. By using the oil and fat absorbent having such an oil absorption amount, it is possible to obtain an adhesive composition for exfoliating keratin capable of forming an adhesive layer having more excellent exfoliating ability.

  In this invention, a commercial item can also be used as an oil-fat absorber. Examples of commercially available products include synthetic zeolite A (manufactured by Wako Pure Chemical Industries, Ltd.), silical (manufactured by Nippon Steel & Mining Co., Ltd.), Urepearl US-01, Urepearl Prototype-501 (manufactured by Konishi), YMC-Pack ODS-A. (Manufactured by YMC Co., Ltd.), fine particle charcoal powder (manufactured by Peach Pig), ultra fine particle silk powder (manufactured by Mandy Moon), and the like.

The addition amount of the fat and oil absorbent is preferably 1 to 50% by mass, and more preferably 2 to 40% by mass with respect to the entire pressure-sensitive adhesive composition for exfoliation.
If the content of the oil / fat absorber is too small, the intended effect of the present invention cannot be obtained. If the content of the oil and fat absorbing material is too large, the followability is lowered, irregularities are formed on the surface, the contact area with the skin is reduced, and the adhesive force may be reduced.

The stratum corneum is composed of a protein mainly composed of keratin and an intercellular lipid mainly composed of ceramide and cholesterol, and is covered with sebum composed of oleic acid glyceride and squalene.
Since the pressure-sensitive adhesive composition for exfoliation of the present invention contains the oil absorbent as described above, it can efficiently absorb and remove sebum covering the surface of the stratum corneum. Therefore, there is no decrease in adhesive strength due to the presence of sebum, and an adhesive layer that is extremely excellent in exfoliating ability can be formed.

The pressure-sensitive adhesive composition for exfoliation of the present invention contains an adhesive component for exfoliating exfoliation in addition to the oil and fat absorbent.
The adhesive component is not particularly limited as long as the keratin can be peeled off by the adhesive force, and examples thereof include a rubber-based adhesive, an acrylic-based adhesive, a silicone-based adhesive, and a urethane-based adhesive. Among these, an acrylic pressure-sensitive adhesive is preferable in terms of easy control of the adhesive force.

The adhesive composition for exfoliation of the present invention preferably has the following adhesive strength. That is, an adhesive composition for exfoliating exfoliation was applied to a 50 μm thick polyethylene terephthalate film so that the basis weight after drying was 30 g / m ² and dried to form an adhesive layer. Adhesive strength (mode: 180 ° peeling, peeling speed: 300 mm / min, sticking time: 5 minutes) in accordance with JIS Z0237 5 minutes after sticking the adhesive sheet to a bakelite plate is 5 to 25 N / 25 mm It is particularly preferable that it is 7 to 20 N / 25 mm. If the adhesive force is less than 5 N / 25 mm, the stratum corneum cannot be effectively peeled off. On the other hand, when the adhesive strength exceeds 25 N / 25 mm, there is a possibility that an adhesive residue may occur on the skin.

The said stratum corneum peeling adhesive composition may further contain other components according to the intended purpose.
Examples of other components include various additives such as drugs, humectants, antioxidants, viscosity modifiers, ultraviolet absorbers, masking agents, plasticizers, waxes, colorants, inorganic fillers, and organic fillers.

  The pressure-sensitive adhesive composition for exfoliating exfoliation can be prepared by appropriately mixing the above-mentioned pressure-sensitive adhesive component and optionally other components and an organic solvent according to a conventional method.

  Examples of the organic solvent used here include aromatic hydrocarbon solvents such as toluene; ester solvents such as ethyl acetate and butyl acetate; ketone solvents such as acetone, methyl ethyl ketone, and methyl isobutyl ketone; n-pentane, n-hexane, and aliphatic hydrocarbon solvents such as n-heptane; alicyclic hydrocarbon solvents such as cyclopentane and cyclohexane; and mixed solvents composed of two or more of these solvents.

  Although the usage-amount of an organic solvent is not specifically limited, It is 5-90 mass% normally with respect to the whole adhesive composition for exfoliation, Preferably it is 10-80 mass%, More preferably, it is 20-70 mass%.

  According to the pressure-sensitive adhesive composition for exfoliating skin of the present invention, an adhesive layer having excellent exfoliating ability can be formed. In particular, the pressure-sensitive adhesive composition for exfoliation of the present invention is useful as a material for forming the pressure-sensitive adhesive layer of the pressure-sensitive adhesive sheet for exfoliation of the present invention described later.

2) The exfoliating pressure-sensitive adhesive sheet The exfoliating pressure-sensitive adhesive sheet of the present invention is characterized by having an adhesive layer comprising the exfoliating pressure-sensitive adhesive composition of the present invention.

  The pressure-sensitive adhesive layer composed of the pressure-sensitive adhesive composition for exfoliation of the present invention is, for example, after diluting the pressure-sensitive adhesive composition for exfoliation of the present invention with an organic solvent such as toluene, ethyl acetate, methyl ethyl ketone, acetone, etc. It can be formed by applying to a support and drying by a conventional method.

  The support to be used is not particularly limited as long as it can support the pressure-sensitive adhesive layer, and can be appropriately selected in consideration of the purpose of use of the resulting exfoliated pressure-sensitive adhesive sheet.

  Supports used include polyester films such as polyethylene terephthalate (PET), polyethylene, polypropylene, ethylene / methacrylic acid copolymers, polyolefin films such as ethylene / methyl methacrylate, polyurethane films, and polystyrene-based thermoplastic elastomers. Resin films such as films; Films obtained by vapor-depositing metals such as aluminum on these resin films; Fibers such as woven fabrics, knitted fabrics and nonwoven fabrics made of various synthetic fibers and / or natural fibers; fine paper, glassine paper, Papers such as coated paper; laminates thereof; and the like.

  The thickness of the support is not particularly limited, but when the support is a resin film, it is usually 5 to 250 μm, preferably 10 to 100 μm, and when the support is made of fibers or papers, Usually, it is 10-1000 micrometers, Preferably it is 20-500 micrometers.

  In addition, surface treatment such as primer treatment, corona treatment, and plasma treatment may be performed in advance on the surface of the support on the side where the pressure-sensitive adhesive layer is formed in order to enhance the adhesion with the pressure-sensitive adhesive layer. In addition, when the obtained exfoliated pressure-sensitive adhesive sheet is used as a wound body suitable for transportation and storage, the surface of the support on which the pressure-sensitive adhesive layer is not formed is coated with a silicone-based release agent, a long-chain alkyl compound, etc. The peeling treatment may be performed by

  Application of the pressure-sensitive adhesive composition for exfoliating exfoliation can be performed using an existing application apparatus. Examples of the coating apparatus include a gravure coater, a Mayer bar coater, a roll coater, a knife coater, a die coater, and a screen coater.

  Although there is no restriction | limiting in particular in drying temperature, Usually, 60-200 degreeC, Preferably it is 80-120 degreeC. Although depending on the drying temperature, the drying time is usually 5 seconds to 10 minutes, preferably 10 seconds to 5 minutes.

The basis weight (mass per unit area) of the obtained adhesive layer is not particularly limited, but is preferably 10 to 200 g / m ² and particularly preferably 15 to 100 g / m ² from the viewpoint of effectively exfoliating the stratum corneum. ² .

  A release sheet may be laminated on the obtained adhesive layer for storage and transportation. The release sheet is peeled off when the keratin peeling adhesive sheet is used.

  Examples of release sheets include paper such as fine paper, glassine paper, coated paper, polyethylene laminated paper, and polypropylene laminated paper; polyester-based films such as PET; synthetic resin films such as polyolefin-based films such as polyethylene and polypropylene; and these One or both surfaces of paper or a synthetic resin film are subjected to a release treatment with a silicone-based release agent, a long-chain alkyl compound, or the like; Of these, a polyester film that has been subjected to a release treatment is preferred from the standpoint of availability and ease of handling.

  The pressure-sensitive adhesive sheet for exfoliation of the present invention has a pressure-sensitive adhesive force (mode: 180 ° peeling, peeling speed: 300 mm / min, sticking time: 5 minutes after sticking the pressure-sensitive adhesive sheet for exfoliation to a bakelite plate. 5 minutes) is preferably 5 to 25 N / 25 mm, and particularly preferably 7 to 20 N / 25 mm. If the adhesive force is less than 5 N / 25 mm, the stratum corneum cannot be effectively peeled off. On the other hand, when the adhesive strength exceeds 25 N / 25 mm, there is a possibility that an adhesive residue may occur on the skin.

Since the pressure-sensitive adhesive sheet for exfoliation of the present invention has a pressure-sensitive adhesive layer obtained from the pressure-sensitive adhesive composition for exfoliation of the present invention, the exfoliation ability is extremely excellent. The exfoliating adhesive sheet of the present invention is excellent in exfoliating ability. For example, the exfoliating adhesive sheet is applied to a human forehead for 5 minutes and then peeled off. It can be confirmed by measuring the amount of exfoliation (μg / cm ² ) with Biorad Laboratories.

  Sebum is hardly confirmed in the skin after exfoliating the stratum corneum with the pressure-sensitive adhesive sheet for exfoliation of the present invention. Since the fat and oil absorbent in the adhesive composition for exfoliating skin of the present invention absorbs sebum, there is no decrease in exfoliating ability due to the presence of sebum, and the adhesive sheet for exfoliating exfoliation of the present invention has excellent exfoliating ability. It is thought to have.

  Whether or not sebum remains on the skin is determined by, for example, applying a keratin exfoliating adhesive sheet to the skin and exfoliating the keratin, holding the filter paper on the exfoliated site for 1 minute, and then removing the filter paper. Leave in osmium tetroxide vapor for 15 minutes. If the sebum remains, the filter paper develops a black color, and if the sebum does not remain, the filter paper does not develop a black color. This is because oleic acid, which is the main component of sebum, and its glycerin ester have an unsaturated double bond in the molecule, so that they undergo an addition reaction with osmium tetroxide and develop a black color.

  Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. The present invention is not limited in any way by these examples.

Example 1
Synthetic zeolite (A-4, Wako Pure Chemical Industries) in an ethyl acetate solution of acrylic adhesive (a copolymer of 70% by mass of 2-ethylhexyl acrylate and 25% by mass of N-vinylpyrrolidone, solid content: 50% by mass). Kogyo Co., Ltd.) was mixed at 20.8% by mass with respect to 100% by mass of the dry weight of the acrylic pressure-sensitive adhesive to obtain a mixed solution 1.
Next, as a release sheet, a PET film release sheet whose one side is release-treated with a silicone resin having a thickness of 38 μm is prepared, and the basis weight after drying is 30 g / m on the release surface of the mixed solution 1. After application so as to be ² , it was dried by heating to form an adhesive layer. On the obtained adhesive layer, a PET film (Lumirror, average thickness: 50 μm, manufactured by Toray Industries, Inc.) as a support was laminated to prepare an exfoliating adhesive sheet 1 for exfoliation.

(Examples 2-9)
In Example 1, instead of the synthetic zeolite 20.8% by mass, the fat and oil absorbent shown in Table 1 below was used in the same manner as in Example 1 except that the amount shown in Table 1 was used. Sheets 2 to 9 were produced. In the table, the oil and fat absorbents A to G represent the following.

A: Synthetic zeolite A-4, Wako Pure Chemical Industries, Ltd. B: Silical, Nittetsu Mining Co., Ltd. C: Urepearl US-01, Konishi Co., Ltd. D: Urepearl Prototype-501, Konishi E: YMC-Pack ODS -A, YMC Co. F: Fine particle charcoal powder, Peach Pig Co. G: Ultra fine particle silk powder, Monday Moon Co.

  The average particle diameter and oil absorption amount of the oil and fat absorbent were measured by the following methods. The results are summarized in Table 1 below.

(1) Average particle size of fat and oil absorbing material Laser diffraction and scattering type particle size distribution measuring device (manufactured by Horiba Seisakusho Co., Ltd.) according to JIS Z8825-1 (particle size analysis-laser diffraction method) , Trade name “LA-920”, He—Ne laser wavelength: 632.8 nm).

In addition, the dispersion liquid at the time of measurement used ethyl acetate only for the fat and oil absorbing material E, and used purified water otherwise. In addition, 100 mg of an oil and fat absorbent was added to 5 mL of the dispersion, and the test liquid that had been shaken for 3 minutes with an ultrasonic shaker was added to a measurement cell in which the same dispersion was filled to 90% capacity in advance. The measurement was performed by adding dropwise and adjusting the light transmittance to be 70 to 95%.
Moreover, the refractive index of each material is as follows: purified water: 1.333, ethyl acetate: 1.372, fat / oil absorber A: 1.5, fat / oil absorber B: 1.5, fat / oil absorber C: 1.5, The fat and oil absorbent D: 1.5, the fat and oil absorbent E: 1.5, the fat and oil absorbent F: 1.8, and the fat and oil absorbent G: 1.4.

(2) Oil absorption amount of fat and oil absorbing material The oil absorption amount of the fat and oil absorbing material was measured according to JIS K5101-13-1 (refined linseed oil method).

(Comparative Example 1)
Except not using synthetic zeolite, it carried out similarly to Example 1, and produced the adhesive sheet 10 for exfoliating exfoliation.

(Comparative Example 2)
A cellophane tape (registered trademark) manufactured by Nichiban Co., Ltd. was used as the exfoliating pressure-sensitive adhesive sheet 11.

  For the exfoliated adhesive sheets 1 to 11 obtained in Examples 1 to 9 and Comparative Examples 1 and 2, the exfoliation amount, the remaining amount of sebum after exfoliation, and the adhesive strength were measured by the methods described below. The results are summarized in Table 1 below.

(1) Measurement of keratin exfoliation amount The keratin exfoliation amount was measured based on the protein quantification method (Lowry method).
First, an adhesive sheet for exfoliating exfoliation is applied to a human forehead for 5 minutes and then exfoliated. / Cm ² ). [Ref: F. Dreher, Colorimetric Method for Quantifying Human Stratum Corneum Removed by Adhesive-Tape-Striping, Acta Derme Venesol (Stock 78) -1898;

(2) Evaluation of remaining amount of sebum The exfoliating pressure-sensitive adhesive sheet was applied to a human forehead for 5 minutes and then peeled off. After fixing the filter paper to the keratin exfoliation site of the forehead for 1 minute, this filter paper was left in osmium tetroxide vapor for 15 minutes. The degree of color development on the filter paper is confirmed with the naked eye, and the amount of sebum remaining on the skin is 1: no sebum remaining (no color development), 2: little sebum remaining (slight color development), 3: there is sebum remaining (color development) Yes).

(3) Adhesive strength Adhering strength (mode: 180 ° peeling, peeling speed: 300 mm / min, pasting time: 5 minutes) in accordance with JIS Z0237 5 minutes after sticking the adhesive sheet for exfoliating keratin to a bakelite plate It was measured.

  From Table 1, the keratin exfoliating pressure-sensitive adhesive sheets 1 to 9 of the present invention have a large amount of exfoliated keratin exfoliating and extremely excellent keratin exfoliating ability as compared with the keratin exfoliating adhesive sheets 10 and 11 of Comparative Examples 1 and 2. I understand.

Claims (6)

  A pressure-sensitive adhesive composition for exfoliating keratin containing an oil and fat absorbent and an adhesive component.   The said fat-and-oil absorber is made of at least one selected from the group consisting of an inorganic material, a resin-based material, an organic-inorganic hybrid material, charcoal, and silk. Agent composition.   3. The keratin exfoliating pressure-sensitive adhesive composition according to claim 1 or 2, wherein the oil and fat absorbent has an oil absorption amount of 50 ml / 100 g or more measured according to JIS K5101-13-1.   4. The oil or fat absorbing material is fine particles having oil absorbing ability, and an average particle diameter measured according to JIS Z8825-1 is 1 to 100 μm. 2. A pressure-sensitive adhesive composition for exfoliation according to 1.   The content of the oil and fat absorbent is 1 to 50 mass% with respect to the entire horny peeling adhesive composition, and the keratin peeling adhesive composition according to any one of claims 1 to 4 .   A pressure-sensitive adhesive sheet for exfoliation having a pressure-sensitive adhesive layer formed from the pressure-sensitive adhesive composition for exfoliation according to claim 1.