JP2011074007A - Sleep-improving agent, and method for evaluating the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sleep-inducing agent by the adjustment of a fragrance tone, having a sleep induction-improving effect and high sleep-inducing effect, and a method for evaluating the effects. <P>SOLUTION: This sleep-improving agent is provided by containing fruity floral-based fragrant components containing ≥1% α-damascone and γ-undecalactone in its fragrant composition as active ingredients, and its effect is evaluated by using a bath agent blended with the sleep-improving agent and measuring at least any one of sleep polysomnography (PSG) or epidermal temperature after bathing. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

The present invention relates to a sleep-improving agent and a method for evaluating the same, and in particular, particularly for sleep disorders caused by changes in the living environment, in particular, increased nighttime activities and irregular day / night life patterns. It is related with the sleep improving agent which improves the problem of falling asleep, and its evaluation method.

In recent years, nearly 60% of people feel stressed at work due to rapid changes in the social environment, such as relationships between companies, schools and families, the development of Internet mail, AV, OA, and IC. Health response is becoming important. In addition, due to such changes in living environment, nighttime activities are increasing, daytime and nightlife patterns are irregular, and diseases caused by sleep disorders are increasing. Causes of insomnia include cases in which the autonomic nervous system, endocrine system, and immune system are lowered due to various concerns and concerns in various stress societies.

In particular, due to an increase in stress in recent years, a method for relieving stress with a fragrance component having a sedative effect has been proposed. For example, a method of orally or transdermally administering an active ingredient to a person, an aromatherapy that vaporizes a fragrance composition and inhales the vapor thereof, and the like have been performed for a long time. Bergamot, lavender, geranium, ylang-ylang, rose and the like are widely known as essential oils that have a sedative effect and relieve stress as a method of dealing with such psychological stress concerns. More specifically, bergamot is a fragrance ingredient that is traditionally said to have a mirror effect, and a technique for its evaluation has been proposed (Patent Document 1) Bitter Orange Essential Oil (Patent Document 2) and Jasmine. It has been proposed to promote arousal by absorbing lactone (Patent Document 3) from the nasal mucosa, oral mucosa or lung tissue. It has also been proposed to use low boiling components of cedarwood oil (α-pinene, α-cedrene, β-cedrene, caryophyllene, etc.) as essential oils for sedation (Patent Document 4).

However, the sedative effects of these components are not determined by academic evaluation results, but by empirical knowledge or sensory tests. In the future, objective and reproducible evaluation methods will be required to study the effects of fragrances on the mental state.

In Patent Document 5 and Non-Patent Document 1, a method is described in which an evaluation target compound is applied using a mask, and the balance of the autonomic nerve is measured by electrocardiogram measurement during sleep onset and sleep. However, since the mask is used in such a method, the test is performed in a situation away from daily life, and the stress due to the use of the mask is likely to affect the test result. As background art related to the present invention, the techniques of Patent Documents 6 to 8 can be cited in addition to the above-mentioned documents.

As a method for solving these problems, it is widely applied to products for the purpose of recovering mental fatigue, reducing stress, refreshing, changing mood, etc. by fragrance or color such as fragrance, bathing agent, aroma oil, incense and spray. Recently, researches on aromatherapy such as relaxation by plant essential oil and Ayurbeta in India are also active. Under such circumstances, bathing agents are a simple method, and mental effects have recently been evaluated using indicators such as brain waves and saliva, as well as research on effects on sleep. .

JP2007-159919 Japanese Patent Laid-Open No. 4-128234 Japanese Patent Laid-Open No. 6-40911 JP-A-5-255688 International Publication No. 01/058435 Pamphlet JP 2005-325070 A JP 2006-062998 A JP 2006-063063 A JP 2007-197334 A JP 2008-0050352 A

Automatic Neuroscuence: Basic and Clinical 108 (2003) pp. 79-86

In view of the above-mentioned present situation, the present invention has an object of providing a sleep improving agent for adjusting incense tone having a sleep improvement effect and having a high sleep induction effect, and a method for evaluating the effect.

The present inventors have found that a fruity floral fragrance component has a sleep improvement effect upon falling asleep, and have completed the present invention. That is, this invention is a sleep improving agent characterized by including a fruity floral fragrance | flavor component as an active ingredient.

The evaluation method of the present invention is performed by measuring at least one of sleep polysomnography (PSG) and epidermis temperature after bathing, using a bath preparation containing the above sleep-improving agent.

ADVANTAGE OF THE INVENTION According to this invention, it has the sleep improvement effect and can provide the sleep improvement agent of adjustment with the incense tone which has a high sleep induction effect, and the method of evaluating the effect.

It is a graph which shows the result of having compared a time-dependent change about the difference of distal (right leg | foot part) and proximal (left chest part) of epidermis temperature in one Embodiment of the sleep improving agent of this invention.

Hereinafter, the present invention will be described in detail.

As a fruity floral fragrance | flavor mix | blended with the sleep improving agent of this invention, it is essential to contain 1% or more of (alpha) -damascon ((alpha) -Damascone) and (gamma) -undecalactone ((gamma) -Undecalactone) in a fragrance | flavor composition. Other fruity floral fragrance components include limonene, linalool, ethyl butylate, phenylethyl alcohol, geraniol, citronellol, hexyl acetate ( Hexyl acetate, Benzaldehyde, Hedione, Iso E super and Galaxolide can be included, and one or more can be added arbitrarily from these, The blending amount is not particularly limited as long as the effects of α-Damascone and γ-Undecalactone are not inhibited.

The method for evaluating a sleep-improving agent of the present invention uses a bathing agent containing the fruity floral fragrance as an active ingredient, and measures at least one of sleep polysomnography (PSG) and epidermal temperature after bathing. This is to evaluate the sleep improvement effect.

EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the present invention, the sleep effect measurement method can be confirmed by the following measurement method. In the following examples, unless otherwise specified, “%” of the composition is mass%.

[Examples and Comparative Examples]
Samples were prepared with the fragrances listed in Table 1, and the sleep asleep effect was evaluated by the following method. The subjects were seven healthy women with consent, and used an emulsion type bath preparation sample (Example) in which a fruity floral fragrance was added and a control sample (Comparative Example) in which no fragrance was added. Table 2 shows the composition of the fruity floral fragrance used in this experiment. It contains 1% α-Damascone and 1% γ-Undecalactone, and other components include Limonene, Linalool, Ethyl Butylate, Phenylethyl alcohol, Geraniol, Citronellol, Hexyl acetate, Benzaldehyde, Hedione, Iso E super, Galaxolide, etc. The inclusion was evaluated as a fruity floral fragrance.

The experiment was conducted for one subject, 3 nights in total, one night of adaptation followed by 2 nights of sample use. For the nights of sample use, the crossover method was used and the order effect was taken into account, and a fruity floral fragrance was used. Either a bathing agent (Example) containing 0.95% or an unscented bathing agent (Comparative Example) was assigned. In addition, the subject confirmed that there was no serious physical history in the past and that there was no big problem in the present sleep habit using the sleep questionnaire. During the experiment, alcoholic beverages, caffeine-containing beverages such as coffee and tea leaf extracts, catecholamine-containing foods and beverages such as bananas and citrus fruits, excessive exercise, and nap were prohibited. In addition, considering the effect of the day of the week on the third night of the experiment, the experiment schedule was adjusted so that all the cases were on the same day of the week.

After having dinner by 19 o'clock, bathing was performed for 15 minutes from 20 o'clock using the bathing agent of the prescription in Table 1. The hot water temperature was 40 ° C., and the bathing agent was adjusted to a concentration of 40 mL with respect to 200 L of tap water.

Between 20:30 and 22:00, electrodes for overnight polysomnography (PSG) recording were mounted and connected to a PSG recording apparatus for physiological calibration. At 22:55, a bed was placed on the bed and a PSG measurement start preparation state was entered. At 23:00, the PSG recording was performed until 7:00 the next morning in a state where the illuminance was 5 lux or less. An epidermis temperature measurement probe was attached to the third and fourth ribs of the right foot and the left chest, and the epidermis temperature was measured using a portable body temperature logger for a long time. The measurement included adaptation nights, and 24 hours of continuous measurement was performed and recorded for 3 days, except when there was a risk of damage to the behavior logger such as bathing. The epidermal temperature was measured from 20:00 to 7:00 the next morning, and recorded continuously for 3 nights. The wake-up time was 7:00, a shower bath was taken to remove the electrode paste attached to the scalp, etc., and after having breakfast, it was dissolved, and it was instructed to continue normal life during the day.

Data analysis was conducted by comparing the difference between Example night and Comparative example night for two nights excluding adaptation night. The sleep stage determination of PSG is performed by the method of Rechtschaffen & Kales (1968). Sleep time (SPT), sleep latency (SL), sleep stages 1-4 and REM sleep latency (
S1-S4, LR) Deep sleep latency (SWSL) REM sleep latency (RL), sleep efficiency (SE), awakening, sleep stage 1-4, time of each stage of REM (Wm, 1m-4m, Rm) And the ratio of each sleep stage (Wr, 1r-4r, Rr).

Table 3 shows the results of the sleep stage according to the sleep 3-minute method (method of analyzing every 150 minutes from bedtime).

As a result of the analysis using the sleep trisection method, the example showed a higher value than the comparative example with respect to the appearance rate of S3 and S4 and the appearance rate of S4 at 23: 00-1: 30. As a result of comparing temporal changes in the difference between the distal (right foot) and proximal (left chest) of the epidermal temperature, the Example showed a significantly higher value in the early stage of sleep than the Comparative Example. (Shown in FIG. 1)

By the sleep 3-minute method, the appearance rate of S3 + S4 and the appearance rate of S4 of the example in the sleep induction period were higher than those of the comparative example, so that the sleep state was improved by the bath agent bath containing the fragrance. I understood. The surface skin temperature is a result of reflecting the contraction and dilation of epidermal capillaries, and this is a result of reflecting changes in the activity of the autonomic nervous system. It is also known that the difference between the distal skin temperature and the proximal skin temperature is greater after sleep on the Example than the comparative example, and the difference between the distal skin temperature and the proximal skin temperature is greater during sleep on the result. Therefore, it is clear that bathing using a bathing agent blended with a fruity floral fragrance has a positive effect on the sleep state during the sleeping process.

1 Example 2 Comparative example

Claims (2)

A sleep-improving agent comprising, as an active ingredient, a fruity floral fragrance component containing 1% or more of α-Damascone and γ-Undecalactone in the fragrance composition. The bath improving agent according to claim 1 is used, and the sleep improving effect is evaluated by measuring at least one of sleep polysomnography (PSG) and epidermis temperature after bathing. Evaluation method of sleep improving agent.

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