JP2011067581A - Transdermal device and method for manufacturing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a transdermal device and a method for manufacturing the transdermal device reusable with no risk of a skin rash caused by an adhesive. <P>SOLUTION: A plurality of elastic granular materials 20 are stuck to a bottom 11 of a cloth part. The elastic granular material 20 includes plurality of holding means 21 holding effective component content bodies (not shown) inside, and an elastic base material 22 covering the plurality of holding means 21. The holding means 21 is structured to eject the effective component content bodies according to external pressure. The elastic base material 22 is adapted to form, according to the external pressure, a plurality of passages 23 for controlling the ejection amount of the effective component content bodies ejected from the holding means 21. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a transdermal device that absorbs an active ingredient such as nicotine from the skin into the body and a method for producing the same.

  When trying to quit smoking, it is especially painful for those who quit smoking for a long time. This is because smoking cessation needs to break away from “lifestyle” and “mental dependence”, and the amount of nicotine accumulated in the body due to smoking cessation decreases, so-called nicotine addiction (addiction) ) ”State. Therefore, as a method of quitting smoking while taking nicotine, there is a method of using a smoking cessation aid. This smoking cessation aid is, for example, a patch-type adhesive impregnated with nicotine, which is applied to the skin and absorbs nicotine from the skin into the body during smoking cessation (see Patent Document 1). In such a smoking cessation method using a smoking cessation aid, the goal is to eventually reduce the nicotine intake to zero while eventually reducing it to zero, and to acquire a habit of quitting during that time.

Patent Document 1: Japanese Patent Application Laid-Open No. 2003-034633

  However, the patch-type adhesive has a problem in that the adhesive is in contact with the skin for a long time, so that the skin is covered with the solvent contained in the adhesive. There is also a problem that the adhesive easily peels off from the skin due to the sweating action from the skin. Furthermore, once the adhesive is detached from the skin, the adhesive strength of the adhesive is weakened, and it is difficult to apply the adhesive to the skin again. That is, there is a problem that the patch type adhesive cannot be reused. These problems also occur when an active ingredient other than nicotine is absorbed into the body from the skin.

  The present invention has been made in view of such problems, and an object of the present invention is to provide a transdermal device that can be used repeatedly without causing a skin irritation caused by an adhesive and a method for producing the same. is there.

  The transdermal device according to the present invention comprises a base material and a plurality of elastic granules fixed to the base material. The plurality of elastic granular materials include a liquid substance or a gel substance, a plurality of holding means having a structure capable of holding the liquid substance or the gel substance inside and discharging the liquid substance or the gel substance according to the pressure from the outside, And an elastic base material covering the holding means. In the elastic base material, a plurality of passages for controlling the discharge amount of the liquid substance or the gel substance discharged from the holding means to the outside are formed according to the pressure from the outside.

  In the transdermal device according to the present invention, the liquid substance or the gel substance is held by a plurality of holding means. Thereby, for example, even when the liquid substance or the gel-like substance has a property that it is difficult to mix with the liquid base material that is a precursor in the manufacturing process of the elastic base material, the plurality of holding means are Since it acts as a relaxation material for relaxing such properties, a liquid substance or a gel substance can be dispersed in the liquid base material in the manufacturing process. As a result, the liquid substance or the gel substance can be finally confined in the elastic base material in a dispersed state. In the transdermal device according to the present invention, the plurality of holding means have a structure capable of discharging a liquid substance or a gel-like substance in accordance with an external pressure. Further, the elastic base material covering the plurality of holding means is formed such that a plurality of passages for controlling the discharge amount of the liquid substance or gel-like substance discharged from the holding means to the outside are formed according to the pressure from the outside. It has become. As a result, for example, when a plurality of elastic granular materials are subjected to pressure by stepping on a plurality of elastic granular materials with a foot or grasping with a hand, a plurality of passages are elastic base materials according to the pressure. The liquid substance or the gel substance in the plurality of holding means is discharged to the outside through the plurality of passages formed in the elastic base material. The discharge amount of the liquid substance or gel substance to the outside is mainly controlled by a passage through which the liquid substance or gel substance passes. The discharged liquid substance or gel substance adheres to, for example, the surface of the foot or hand (skin) where pressure is applied to a plurality of elastic granules, and then penetrates the skin and is absorbed into the body.

The method for manufacturing a transdermal device according to the present invention includes the following two steps.
(1) By holding a liquid substance or a gel-like substance inside and mixing a plurality of holding means for discharging in accordance with the pressure from the outside into the liquid base material and stirring, the plurality of holding means become fine spherical particles. (2) A step of heating the dispersion on the surface of the substrate after the dispersion is disposed at a predetermined position on the surface of the substrate.

  In the method for producing a transdermal device according to the present invention, a liquid substance or a gel substance is held by a plurality of holding means. Thereby, for example, even when the liquid substance or the gel-like substance has a property that it is difficult to mix with the liquid base material that is a precursor in the manufacturing process of the elastic base material, the plurality of holding means are Since it acts as a relaxation material for relaxing such properties, a liquid substance or a gel substance can be dispersed in the liquid base material in the manufacturing process. As a result, the liquid substance or the gel substance can be finally confined in the elastic base material in a dispersed state. Moreover, in the method for manufacturing a transdermal device according to the present invention, the plurality of holding means have a structure capable of discharging a liquid substance or a gel-like substance in accordance with an external pressure. Further, the dispersion is heated while being placed on the surface of the substrate. As a result, an elastic base material is formed in which a plurality of passages for controlling the discharge amount of the liquid substance or gel substance discharged from the holding means to the outside can be formed according to the pressure from the outside. As a result, when a pressure is applied to the plurality of elastic granules by, for example, stepping on the plurality of elastic granules with a foot or grasping with a hand, the plurality of passages are elastic base materials according to the pressure. The liquid substance or the gel substance in the plurality of holding means is discharged to the outside through the plurality of passages formed in the elastic base material. The discharge amount of the liquid substance or gel substance to the outside is mainly controlled by a passage through which the liquid substance or gel substance passes. The discharged liquid substance or gel substance adheres to, for example, the surface of the foot or hand (skin) where pressure is applied to a plurality of elastic granules, and then penetrates the skin and is absorbed into the body.

  According to the transdermal device and the method for producing the same according to the present invention, an appropriate amount of a liquid substance or a gel substance can be absorbed into the body through the skin without using an adhesive. Furthermore, a liquid substance or a gel-like substance can be absorbed into the body through the skin only by applying pressure to the plurality of elastic granular materials. Thus, the transdermal device can be repeatedly used while the liquid substance or the gel-like substance remains in the transdermal device. From the above, there is no risk of skin irritation caused by the pressure-sensitive adhesive, and it can be used repeatedly.

It is a figure showing the schematic structure of the sock for smoking cessation which concerns on 1st Embodiment by this invention, and the upper surface structure of the contact surface which touches a sole among the bottom parts of the sock for smoking cessation. It is a figure showing an example of the cross-sectional structure of the elastic granular material of FIG. It is a figure showing an example of the holding means of FIG. It is the figure showing the other example of the cross-sectional structure of the elastic granular material of FIG. It is a figure showing an example of the cross-sectional structure of the holding means of FIG. It is a figure for demonstrating an example of the manufacturing method of the holding means of FIG. It is a figure for demonstrating the other example of the manufacturing method of the holding means of FIG. It is a figure showing schematic structure of the sheet for smoking cessation concerning a 2nd embodiment by the present invention. It is a figure showing a mode that the sheet for smoking cessation of Drawing 8 was wound around the grip member. It is the figure showing a mode that one elastic granular material was provided in the sheet | seat for smoking cessation of FIG.

DESCRIPTION OF EMBODIMENTS Hereinafter, embodiments for carrying out the invention will be described in detail with reference to the drawings. The description will be given in the following order.
1. 1st Embodiment (FIGS. 1-3)
○ Examples where socks are used as a base material ○ Examples where a porous material is used as a holding means ○ Examples where an active ingredient-containing body contains nicotine as an active ingredient ○ Multiple elastic granules are provided Example 2. Modified example of the first embodiment (FIGS. 4 to 7)
An example in which a flexible membrane is used as a holding means Second embodiment (FIGS. 8 and 9)
○ Examples where fabrics are used as the base material ○ Examples where porous materials or flexible membranes are used as holding means ○ Examples where the active ingredient-containing body contains nicotine as an active ingredient ○ Multiple elastic granules Example where the base material is affixed to the grip member. Modification of the second embodiment (not shown)
○ Example where the base material is affixed to socks, etc. Modification common to the first and second embodiments ○ Example in which the active ingredient-containing body contains a substance other than nicotine as an active ingredient ○ Example in which one elastic granule is provided (FIG. 10)

<First Embodiment>
(About configuration)
FIG. 1A shows an example of a schematic configuration of a non-smoking sock 1 according to the first embodiment of the present invention. FIG. 1B illustrates an example of a schematic configuration of a contact surface 11A (inner surface) in contact with the sole of the bottom 11 of the non-smoking sock 1 illustrated in FIG. The non-smoking sock 1 corresponds to a specific example of the “transdermal device” of the present invention. The bottom 11 corresponds to a specific example of the “base material” of the present invention.

  The sock 1 for smoking cessation is a kind of smoking cessation aid such as a nicotine patch and nicotine gum, and is for smoking cessation while ingesting nicotine. The non-smoking sock 1 includes a cloth portion 10 and a plurality of elastic granular materials 20. The cloth part 10 is constituted by a woven fabric or a non-woven fabric. The cloth part 10 has, for example, a cylindrical shape having an opening 10A at one place, and is put into the cloth part 10 when a foot tip is put into the cloth part 10 through the opening 10A. The shape can be along the skin of the part. Here, the tip of the foot indicates, for example, a portion of the right foot or the left foot ahead of the ankle.

  In addition, although not shown in figure, the cloth part 10 may have the opening 10A in two places, for example. In this case, one opening 10A is an opening into which a foot is inserted when wearing the non-smoking sock 1, and the other opening 10A is an opening exposing the toe when the non-smoking sock 1 is worn. It has become.

  The plurality of elastic granules 20 are fixed to the bottom part 11 of the cloth part 10. More specifically, when the user wears the sock 1 for smoking cessation, the user touches the sole of the bottom part 11 of the cloth part 10. It is fixed to the contact surface 11A (inner surface). In other words, the plurality of elastic granular materials 20 are arranged at positions where most of the plurality of elastic granular materials 20 are in contact with the soles when the user stands or walks while wearing the non-smoking socks 1. Has been. As shown in FIG. 1 (B), for example, the plurality of elastic granular materials 20 are arranged from a portion corresponding to the toe to a portion corresponding to the heel at approximately equal intervals.

  In addition, although not shown in figure, the some elastic granular material 20 may be arrange | positioned only in parts other than the part corresponding to heel among 11 A of contact surfaces. Moreover, although not shown in figure, the some elastic granular material 20 may be arrange | positioned so that it may become non-uniform density distribution in the contact surface 11A.

  2A and 2B show an example of a cross-sectional configuration of one elastic granule 20. 2A shows an example of a cross-sectional configuration of the elastic granular material 20 before the user uses the sock 1 for smoking cessation, and FIG. 2B shows the sock 1 for smoking cessation by the user. An example of the cross-sectional structure of the elastic granular material 20 after using is represented. 2A and 2B are schematic representations and do not necessarily match the actual scale.

  Each elastic granule 20 includes, for example, a plurality of holding means 21 for holding an active ingredient-containing body (not shown) inside and a plurality of holding means 21 as schematically shown in FIG. An elastic base material (matrix) 22 is covered. The active ingredient-containing body is, for example, a liquid substance. A liquid substance refers to a low-viscosity substance that is difficult to maintain its shape by itself. The active ingredient-containing body contains nicotine as an active ingredient.

Here, nicotine is a substance having a chemical formula represented by C ₁₀ H ₁₄ N _2. For example, nicotine has a common configuration with i-stachydrin and L-proline separated by synthesizing racemic nicotine with tartaric acid. It has a substance. These types of nicotine are colorless, oily liquids that are water soluble. Therefore, when this type of water-soluble oily nicotine is contained in the active ingredient-containing body, the water-soluble oily nicotine dissolves in sweat (physiological water) and is easily taken from the skin. However, since the water-soluble oily liquid nicotine has a property of turning brown in the air when heated to 247 ° C., in the manufacturing process described later, for example, a liquid that is a precursor of the elastic base material 22 As the temperature for solidifying the base material 24, a material that can be set to a temperature at which the water-soluble oily liquid nicotine does not change to brown is preferably selected as the liquid base material 24. Note that nicotine different from the water-soluble oily liquid nicotine described above may be included in the active ingredient-containing body as an active ingredient.

  The plurality of holding means 21 have a structure capable of discharging the active ingredient-containing body in accordance with external pressure. The plurality of holding means 21 has a porous structure having a large number of fine voids inside as such a structure, and is made of, for example, a porous material. The active ingredient-containing body is accommodated in the voids in the porous structure. The plurality of holding means 21 are configured to discharge the internal active ingredient-containing body when the pressure from the outside exceeds a predetermined value. The diameter of each holding means 21 is, for example, a scale (for example, several hundred μm) smaller by one digit or more than the scale (for example, several mm) of each elastic granular material 20. Each gap in each holding means 21 has a scale (for example, several tens of μm) smaller by one digit or more than the scale (for example, several hundred μm) of each holding means 21. The porous material has high water absorption and high water retention.

High water absorption means that when water is poured into the porous material, the porous material absorbs a larger amount of water than the weight of the porous material. In addition, high water retention means that a porous material is placed in a container having a large number of fine openings on the bottom so that the porous material does not fall off, and water is poured into the container, and then the porous material in the container is filled with water. When a plate made of resin or the like is placed on the entire upper surface, and the surface pressure of a predetermined size is applied to the resin, the water in the container does not continuously leak out from the bottom of the container. pointing. Here, the above-mentioned predetermined size is that when the non-smoking sock 1 is washed with a washing machine or the like, the porous material is destroyed or the water absorbed in the porous material is extracted into the water tank of the washing machine. It is preferable that the size is not reduced (for example, 3 kg / cm ² or more). In addition, the predetermined size described above is such that when the infant steps on or bites the sock 1 for smoking cessation, the porous material is not destroyed or the water absorbed in the porous material is not extracted to the outside. More preferably (for example, 15 kg / cm ² or more).

  The above “plentiful” means pouring as much water as possible within a range not exceeding the upper limit of the amount of water that can be absorbed by the porous material. However, the upper limit of the amount of water that can be absorbed by the porous material varies depending on the temperature of the porous material and water. Therefore, when water is absorbed into the porous material in a state where the temperature of the porous material and water is higher than room temperature (100 ° C. or less), the temperature of the porous material and water is kept at room temperature. A larger amount of water can be absorbed by the porous material than when the porous material absorbs water. By the way, if the porous material and water are absorbed in a state where the temperature of the porous material and water is higher than room temperature and then the temperature of the porous material and water is decreased, the porous material and water are absorbed by the porous material. The formed water is condensed on the surface of the porous material due to supersaturation. Therefore, for example, after the porous material and the active ingredient-containing body are absorbed at a temperature higher than room temperature, the porous material that has absorbed the active ingredient-containing body is absorbed into the porous material. After mixing with the liquid base material 24 and finally creating the elastic granular material 20, when the temperature of the porous material that has absorbed the active ingredient-containing material is brought to room temperature, the effective that has been absorbed by the porous material The component-containing body is condensed on the surface of the porous material in the elastic base material 22.

  Moreover, the magnitude | size of the pressure shown above illustrated the value when this invention is applied to the use of the non-smoking sock 1, and when applied to another use, it is the same value as the above. It does not always become. In addition, “the water does not continuously leak” means that the water does not flow down like a rod but falls down.

  Among the porous materials, materials having high water absorption and high water retention can be classified into, for example, inorganic porous materials and organic porous materials. Here, examples of the porous material made of an inorganic material include zeolite. Moreover, as a porous material which consists of organic substance, diatomaceous earth, a high water content polymer, and fibrous powder are mentioned, for example. Zeolite is a trade name of an aluminosilicate having fine pores in the crystal. Diatomaceous earth is a deposit (sedimentary rock) made of fossil diatom shells, which is a kind of algae, and is mainly composed of silicon dioxide. Highly water-containing polymers are, for example, (1) Ammonium salt of a high polymer organic acid, (2) Na-Carboxymethyl ssyl, (3) Aqueous solution of acrylic (4) copolymer, (6) Aqueous solution of ammonium polymethylate, (7) Ammonium polyalylate, (8) Sodium polyalylate, (9) Modified soytipolypoly (10) Examples thereof include dized polyacrylate, (11) Potassium salt of vinyl polymers, or (12) Modifications and derivatives of the polymers described in (1) to (11) above. The fibrous powder is composed of fibrous carbohydrates (polysaccharides) such as cellulose. Therefore, zeolite, diatomaceous earth, highly water-containing polymer, and fibrous powder can all be safe materials for the human body.

  “Safe to the human body” means that, for example, the porous material and the sponge-like material do not cause rash on the skin when they touch the skin. When a material other than zeolite and diatomaceous earth is selected as the porous material and sponge-like material, it is preferable that the material is a material that is safe for the human body, like zeolite and diatomaceous earth. When the plurality of holding means 21 are configured to contain zeolite or diatomaceous earth, for example, as shown in FIG. 3, a large number of fine particles 21 </ b> A are aggregated, and voids in the particles 21 </ b> A are present. Contains an active ingredient-containing body.

  For example, as shown in FIG. 2A, the elastic base material 22 is fixed to the bottom part 11 of the cloth part 10, and more specifically, to the contact surface 11A of the bottom part 11 of the cloth part 10. Has been. For example, in the manufacturing process described later, the elastic base material 22 is made into a fiber by allowing the liquid base material 24, which is a precursor of the elastic base material 22, to penetrate into the gaps of the fibers of the cloth portion 10 and then solidifying the fibers. It is fixed with a tie (anchor shape). Thereby, the elastic base material 22 is fixed to the cloth part 10 as if it was printed.

  For example, as shown in FIG. 2A, the elastic base material 22 covers the plurality of holding means 21 and has, for example, an island-like convex shape. The elastic base material 22 has a plurality of passages 23 for controlling the discharge amount of the active ingredient-containing body (liquid substance or gel-like substance) discharged from at least one holding means 21 among the plurality of holding means 21 to the outside (FIG. 2 (B)) is formed according to the pressure from the outside. Therefore, when a pressure of a predetermined level or more is applied from the outside repeatedly to the elastic base material 22, the elastic base material 22 is formed on the elastic base material 22 according to the number of times the pressure of a predetermined level or more is applied. The number of passages 23 increases. The above-described properties of the elastic base material 22 are manifested by evaporation of volatile components (for example, moisture) contained in the liquid base material 24 described later or the active ingredient-containing body in the manufacturing process.

  The plurality of passages 23 may already be formed inside the elastic base material 22 when the smoking sock 1 is not used. In this case, however, the ends of the plurality of passages 23 are not exposed on the surface of a portion different from the portion in contact with the fabric portion 10 of the elastic base material 22 when the non-smoking sock 1 is not used. It is preferable.

  The elastic base material 22 includes, for example, a one-component addition type silicone, a two-component addition type silicone, a rubber latex, or a self-crosslinking type emulsion. These materials are safe for the human body. When a material other than the materials exemplified above is selected as the material of the elastic base material 22, it is preferable that the material is a material safe for the human body.

(About manufacturing method)
Next, an example of the manufacturing method of the non-smoking sock 1 of this Embodiment is demonstrated. Hereinafter, a production method in the case where the active ingredient-containing body is a liquid material will be described.

  First, as the liquid base material 24 which is a precursor in the manufacturing process of the elastic base material 22, for example, a liquid one-component addition type silicone, a liquid two-component addition type silicone, a liquid rubber latex, or a liquid self-crosslinking Prepare a mold emulsion. The process temperature and process time shown below are specific examples when liquid two-component addition type silicone is used as the liquid base material 24, but specific examples when other materials are used as the liquid base material 24. The values are applicable as examples.

  Subsequently, although not shown in the drawing, the liquid base material 24 is mixed with a plurality of holding means 21 for holding the active ingredient-containing body therein to create a mixed liquid, and then the mixed liquid is stirred, whereby a plurality of holding means are obtained. A dispersion liquid 25 in which 21 becomes fine spherical particles and is dispersed in the liquid base material 24 is created.

  Next, a mask (not shown) used in a transfer process described later is prepared. In this mask, for example, a resin layer (not shown) having a plurality of openings is formed on the surface of a mesh-like base material. Further, a thin plate (not shown) is prepared for use in making the shape of the cloth portion 10 a predetermined shape in a transfer step described later. This thin plate is a thin plate having a shape and a size corresponding to the bottom portion 11 of the cloth portion 10, for example, an aluminum thin plate having a thickness of 1.5 mm and having a substantially elliptic shape with both ends formed into a semicircular shape. is there. Then, a thin plate is put in the cloth part 10B which turned the cloth part 10 upside down. Thereby, for example, since the arrangement of the fabric weave is arranged and the wrinkles extend, the dispersion liquid 25 can be transferred to the correct position.

  Next, after the dispersion 25 is dropped on the surface of the mask, the printing iron (not shown) is moved while being rubbed against the surface of the mask. In this way, the dispersion liquid 25 is spread over the entire surface of the mask, and the dispersion liquid 25 is transferred to the contact surface 11A of the cloth portion 10B through each opening of the mask, so that the dispersion liquid 25 is added to the cloth portion 10B. It penetrates into the bottom part 11 and bites into the fibers of the cloth part 10 to form an island-like convex shape.

  The transfer of the dispersion liquid 25 to the contact surface 11A is not limited to the above-described screen printing method, and may be performed by other methods such as a hot press method. In addition, when the dispersion liquid 25 is transferred to the contact surface 11A, the process temperature is preferably room temperature. This is because the degree of freedom in selecting the material of the mask base material can be increased. The process temperature may be higher than room temperature, but is preferably lower than the temperature at which the water-soluble oily nicotine contained in the dispersion 25 changes to brown.

  Next, hot air (for example, 200 ° C.) is applied to the dispersion 25 on the cloth 10B to heat the dispersion 25 on the cloth 10B. Thereby, the dispersion liquid 25 on the cloth part 10B is firmly fixed to the contact surface 11A through a history of solidification by heating. Further, due to the heating, secondary cross-linking occurs in the liquid base material 24 contained in the dispersion 25, and the remaining vaporized oxide is decomposed and removed to form the elastic base material 22. Furthermore, moisture is vaporized from the active ingredient-containing body contained in the dispersion liquid 25, and the passage 23 or the precursor of the passage 23 is formed in the elastic base material 22. Note that the front casing of the passage 23 is a portion having a fragile property such that the passage 23 is formed by pressure applied when the non-smoking sock 1 is used, or a width that is extremely narrower than the width of the passage 23. It refers to the fine passage that has. In the case where the liquid base material 24 is composed of a material containing a volatile component (for example, water), specifically, a rubber latex or a self-crosslinking emulsion, the liquid base material 24 itself also contains water. As a result of vaporization, the passage 23 or the front casing of the passage 23 is formed in the elastic base material 22. In this way, the non-smoking sock 1 of the present embodiment is manufactured.

(About effect)
In the non-smoking sock 1 of the present embodiment, the active ingredient-containing body is held by a plurality of holding means 21. Thereby, even if the active ingredient-containing body has a property that is difficult to mix with the liquid base material 24, the plurality of holding means 21 act as a relaxation material that relaxes such a property. The active ingredient-containing body can be dispersed in the liquid base material 24. As a result, the active ingredient-containing body can be confined in a state of being finally dispersed in the elastic base material 22. Moreover, in the sock 1 for smoking cessation, the plurality of holding means 21 has a structure capable of discharging the active ingredient-containing body in accordance with an external pressure. Further, the elastic base material 22 covering the plurality of holding means 21 is formed with a plurality of passages 23 for controlling the discharge amount of the active ingredient-containing body discharged from the holding means 21 to the outside according to the pressure from the outside. It is like that. Thereby, for example, when a plurality of elastic granular materials 20 are stepped on with a foot and pressure is applied to the plurality of elastic granular materials 20, a plurality of passages 23 are formed in the elastic base material 22 according to the pressure. In addition, the active ingredient-containing body in the plurality of holding means 21 is discharged to the outside through the plurality of passages 23 formed in the elastic base material 22. The discharge amount of the active ingredient-containing body to the outside is controlled by the number and diameter of the passages 23 through which the active ingredient-containing body passes and the number, size, and shape of the elastic granules 20. For example, the discharged active ingredient-containing body adheres to the sole of the foot that has been pressed against the plurality of elastic granular bodies 20, and then penetrates the skin of the sole and is absorbed into the body. As described above, in the sock 1 for smoking cessation, an appropriate amount of the active ingredient-containing body can be absorbed into the body through the skin without using an adhesive. Furthermore, in the sock 1 for smoking cessation, the active ingredient-containing body can be absorbed into the body through the skin only by applying pressure to the plurality of elastic granular bodies 20. Thereby, while the active ingredient containing body remains in the non-smoking sock 1, the user can reuse the non-smoking sock 1. From the above, according to the sock 1 for smoking cessation, there is no possibility of causing skin irritation caused by the adhesive, and it can be reused.

  Moreover, in this Embodiment, the site | part which absorbs an active ingredient containing body becomes a sole. The skin on the sole of the foot is less likely to rub against not only the adhesive but also nicotine itself. Therefore, according to the sock 1 for smoking cessation, there is no possibility of causing skin irritation caused not only by the adhesive but also by nicotine itself. Moreover, in this Embodiment, since the some elastic granular material 20 is adhering to the fibrous sheet called the cloth part 10, the cloth part 10 does not prevent skin respiration of the sole. Therefore, there is no possibility of causing skin irritation caused by obstructing skin respiration.

  Further, in the manufacturing process of the present embodiment, after the holding means 21 absorbs the active ingredient-containing body in a state where the temperature of the holding means 21 and the active ingredient-containing body is higher than normal temperature, the active ingredient-containing body is absorbed. When the holding means 21 that absorbs the active ingredient-containing body is mixed with the liquid base material 24 and finally creates the elastic granular material 20, the holding means 21 that has absorbed the active ingredient-containing body is brought to room temperature. The active ingredient-containing body absorbed in 21 is condensed on the surface of the holding means 21 in the elastic base material 22. As a result, the active ingredient-containing body condensed on the surface of the holding means 21 is more easily discharged to the outside than the active ingredient-containing body absorbed by the holding means 21. The discharge amount of the component-containing body can be increased. Therefore, in this case, the immediate effect is excellent.

  By the way, the nicotine patch that is currently popular as a kind of smoking cessation aid is brought into contact with the skin using an adhesive. Therefore, since the adhesive is in contact with the skin throughout the use of the nicotine patch, there is a problem that the skin is rashed by the solvent contained in the adhesive. There is also a problem that the adhesive easily peels off from the skin due to the sweating action from the skin. Furthermore, once the adhesive is detached from the skin, the adhesive strength of the adhesive is weakened, and it is difficult to apply the nicotine patch to the skin again. In other words, there was a problem that the nicotine patch could not be reused.

  This non-reusability has been a problem in practice in the following cases. For example, suppose that a user peels off a nicotine patch when the user feels bad due to over-doze. At this time, it is assumed that nicotine remains in the nicotine patch. Thereafter, the user's mood is restored, and the user tries to reuse the nicotine patch and applies it to the skin again. However, since the adhesive has weakened adhesive strength, it peels off immediately and the user cannot use the nicotine remaining in the nicotine patch. As a result, the user has to discard the nicotine patch and use a new nicotine patch, so the problem is that the user has to frequently dispose of the nicotine patch in order to properly control overdose. Has occurred. The frequent disposal of expensive nicotine patches increases the economic burden on the user, and may hinder the continuity of smoking cessation.

  On the other hand, in this embodiment, the active ingredient-containing body is absorbed into the body based on a principle different from the conventional ingestion method in which the nicotine exuded from the nicotine patch is absorbed into the body by attaching the nicotine patch to the skin with an adhesive. Let Specifically, for example, the plurality of elastic granules 20 are stepped on with a foot so that the plurality of elastic granules 20 are brought into contact with the skin of the sole and the active ingredient-containing body is oozed out of the plurality of elastic granules 20. The active ingredient-containing body that has exuded is absorbed into the body. As a result, the user can take off or put on the smoking sock 1 any number of times, so that while the active ingredient-containing body remains in the smoking sock 1, the user can However, it is possible to reuse the sock 1 for smoking cessation. As a result, the user can appropriately control the overdose simply by taking off or wearing the smoking sock 1. Therefore, the sock 1 for smoking cessation has a very low economic burden on the user and promotes continuation of smoking cessation.

<Modification of the first embodiment>
[Modification 1]
(About configuration)
In the above embodiment, each elastic granule 20 includes a plurality of holding means 21 having a porous structure. For example, as shown in FIG. Instead, a plurality of holding means 26 may be incorporated. Similar to the plurality of holding means 21, the plurality of holding means 26 have a structure capable of discharging the active ingredient-containing body in accordance with an external pressure. The plurality of holding means 26 have, as such a structure, for example, a flexible film 28 that covers the active ingredient-containing body 27 as schematically shown in the cross-sectional view of FIG. The flexible membrane 28 is ruptured when the pressure from the outside exceeds a predetermined value, and discharges the internal active ingredient-containing body 27.

  The diameter (particle diameter) of the flexible membrane 28 (holding means 26) is, for example, a scale (for example, several hundred μm) smaller by one digit or more than the scale (for example, several millimeters) of each elastic granular material 20. The film thickness of the flexible film 28 is a value smaller than ½ of the particle diameter of the flexible film 28. The particle diameters of all the flexible films 28 included in one elastic granule 20 may be uniform or may not be uniform. As an example in which the particle diameters of all the flexible films 28 included in one elastic granular body 20 are not uniform, a plurality of flexible films 28 included in one elastic granular body 20 include a plurality of different particle diameters. The case where it is comprised by the kind of flexible film | membrane 28 is mentioned. The softness (or film thickness) of the flexible film 28 included in one elastic granule 20 may be uniform or may not be uniform. As an example in which the softness (or film thickness) of all the flexible films 28 included in one elastic granular body 20 is not uniform, a plurality of flexible films 28 included in one elastic granular body 20 include: The case where it is comprised by the multiple types of flexible film | membrane 28 from which softness (or film thickness) differs is mentioned. The particle diameters of all the flexible films 28 included in one elastic granular body 20 are not uniform, and the softness of all the flexible films 28 included in one elastic granular body 20 (or The film thickness may not be uniform.

  As described above, when at least one of the particle size and softness (or film thickness) of the flexible film 28 is not uniform in all the flexible films 28 included in one elastic granular body 20, The ease with which each flexible film 28 is ruptured against an external pressure varies depending on the particle size and softness (or film thickness) of the flexible film 28. Of course, even when the soft film 28 has a uniform particle diameter and softness (or film thickness) in all the soft films 28 included in one elastic granule 20, the soft film 28 is not affected by pressure from the outside. The ease of rupture varies depending on the position of the flexible film 28 in the one elastic granule 20, the positional relationship of the flexible film 28 with the passage 23, and the like.

  The active ingredient containing body 27 is, for example, a gel substance. The gel-like substance is a semi-solid substance, and refers to a medium-viscosity substance or a high-viscosity substance that can maintain its shape independently. The active ingredient-containing body 27 contains nicotine as an active ingredient, as in the first embodiment. This nicotine is the same as that in the first embodiment. On the other hand, the flexible film 28 is a thin and soft film that bends in response to an external pressure. For example, a heat-sensitive gelling material such as agar, konjac, and gelatin, a calcium chloride aqueous solution (nigari), or the like. It is formed by mixing (or contacting) the solidified material. The coagulant is not limited to an aqueous calcium chloride solution, and may be, for example, an aqueous solution of a polyvalent salt such as magnesium chloride. In this embodiment, the elastic base material 22 is configured to include a material containing a volatile component (for example, moisture), for example, a rubber latex or a self-crosslinking emulsion.

(About manufacturing method)
Next, an example of a method for manufacturing the non-smoking sock 1 according to this modification will be described. Hereinafter, a production method in the case where the active ingredient-containing body is a gel substance will be described.

  First, the gelled material mentioned above is boiled and melted in water. Next, an oily nicotine and various additives (for example, an aqueous solution of sodium alginate) are added to the solution and mixed together to prepare a mixed solution. (Not shown).

  Next, the dispersion liquid 29 is put into a heated solution tank 500, and the dispersion liquid 29 is heated at a predetermined temperature (for example, 70 ° C. ± 10 ° C.) (see FIG. 6). For example, a large number of holes 510 are provided on the bottom surface of the solution tank 500, and the solution tank 500 can drop the dispersion liquid 29 in the solution tank 500 through the plurality of holes 510. It has become. The diameter of each hole 510 is, for example, a scale (for example, several hundred μm) smaller by one digit or more than the scale (for example, several mm) of each elastic granular material 20. The diameters of the holes 510 may be equal to each other or may not be equal to each other. While the dispersion liquid 29 is not dropped from the solution tank 500, the hole 510 is sealed.

  The particle size of the flexible membrane 28 can be changed by adjusting the diameter of the hole 510. Accordingly, when it is desired to form a plurality of types of flexible membranes 28 having different particle diameters, for example, as the solution tank 500, a solution tank having a plurality of types of holes 510 having different particle diameters on the bottom surface is prepared. What is necessary is just to prepare the some solution tank which made the particle size of the hole 510 differ for every solution tank.

  Next, a solution tank 600 in which the solution 30 made of the above-described coagulant is put is prepared immediately below the solution tank 500. Subsequently, the hole 510 is unblocked, and the dispersion 29 is dropped into the solution 30 (FIG. 6). The dispersion liquid 29 after being dropped from the holes 510 has a spherical shape, for example, as shown in FIG. When the spherical dispersion liquid 29 (spherical dispersion liquid 29A) is immersed in the solution 30, the surface portion of the spherical dispersion liquid 29A reacts with the solution 30 and solidifies to form the flexible film 28. The film thickness of the flexible film 28 can be controlled by the immersion time in the solution 30 and the concentration of the solidified material. Thereafter, although not shown, the flexible film 28 holding the dispersion liquid 29 is washed to remove the solution 30 from the surface of the flexible film 28. In this way, a plurality of holding means 26 for holding the active ingredient-containing body 27 inside is created.

  In addition, the some holding | maintenance means 26 which hold | maintains the active ingredient containing body 27 inside is also producible also with the following manufacturing methods, for example. First, the dispersion liquid 29 is created using the method described above (not shown). Next, the dispersion liquid 29 is put into a cooled solution tank, and the dispersion liquid 29 is cooled and solidified to produce a solid material 29B (FIG. 7A). Subsequently, the solid material 29B is pulverized with a mixer or the like into a plurality of crushed pieces 29C (FIG. 7B). The diameter of each crushed piece 29C is, for example, a scale (for example, several hundred μm) smaller by one digit or more than the scale (for example, several mm) of each elastic granule 20.

  Next, a solution tank 600 in which the solution 30 made of the above-described coagulant is placed is prepared. Subsequently, a plurality of crushed pieces 29C are put into the solution 30 (FIG. 7C). When the plurality of crushed pieces 29 </ b> C are immersed in the solution 30, the surface portion thereof reacts with the solution 30 to solidify, thereby forming the flexible film 28. Thereafter, although not shown, the flexible membrane 28 holding the crushed pieces 29C is washed to remove the solution 30 from the surface of the flexible membrane 28. In this way, a plurality of holding means 26 for holding the active ingredient-containing body 27 inside is created.

  Next, the non-smoking sock 1 is created using the plurality of holding means 26 that holds the active ingredient-containing body 27 inside as described above. Specifically, first, although not shown, by mixing the liquid base material 24 with a plurality of holding means 26 for holding the active ingredient-containing body 27 therein to create a mixed solution, the mixed solution is stirred. The plurality of holding means 26 form fine spherical particles to create a dispersion 31 dispersed in the liquid base material 24.

  Next, as in the above-described embodiment, the dispersion liquid 31 is transferred to the contact surface 11A of the fabric portion 10B using, for example, a screen printing method. Next, hot air (for example, 200 ° C.) is applied to the dispersion 31 on the cloth part 10B to heat the dispersion 31 on the cloth part 10B. Thereby, the dispersion liquid 31 on the cloth part 10B is firmly fixed to the contact surface 11A through a history of solidification by heating. Further, by heating, secondary cross-linking occurs in the liquid base material 24 contained in the dispersion 31, and the remaining vaporized oxide is decomposed and removed to form the elastic base material 22. Further, volatile components (for example, moisture) contained in the liquid base material 24 are vaporized, and the passage 23 or the precursor of the passage 23 is formed in the elastic base material 22. In addition, since an active ingredient containing body is a gel-like substance, the water | moisture content contained in an active ingredient containing body hardly evaporates. In this way, the non-smoking sock 1 of this modification is manufactured.

(About effect)
In this modification, the active ingredient containing body 27 is held by a plurality of holding means 26. Thereby, the active ingredient containing body 27 can be confined in a state of being finally dispersed in the elastic base material 22. Moreover, in this modification, it has a structure in which the some holding | maintenance means 26 can discharge the active ingredient containing body 27 according to the pressure from the outside. Further, the elastic base material 22 covering the plurality of holding means 26 is formed with a plurality of passages 23 for controlling the discharge amount of the active ingredient-containing body 27 discharged from the holding means 26 to the outside according to the pressure from the outside. It has become so. Thereby, an appropriate amount of the active ingredient-containing body 27 can be absorbed into the body through the skin without using an adhesive. Furthermore, in this modification, the active ingredient containing body 27 can be absorbed into the body through the skin only by applying pressure to the plurality of elastic granular bodies 20. Thus, while the active ingredient-containing body 27 remains in the non-smoking sock 1 according to this modification, the user can reuse the non-smoking sock 1 according to this modification any number of times. From the above, according to the sock 1 for smoking cessation according to the present modification, there is no risk of skin irritation caused by the adhesive, and it can be reused.

  Moreover, in this modification, the site | part which absorbs the active ingredient containing body 27 becomes a sole like the said embodiment. Therefore, according to the sock 1 for smoking cessation according to this modification, there is no possibility of causing skin irritation caused by nicotine itself as well as the adhesive. Moreover, in this modification, since the some elastic granular material 20 is adhering to the fibrous sheet called the cloth part 10, like the said embodiment, the cloth part 10 does not prevent skin respiration of the sole. Therefore, there is no possibility of causing skin irritation caused by obstructing skin respiration.

  In addition, since it is possible to reuse the non-smoking sock 1 according to the present modification, the user can appropriately overdoze by simply taking off or wearing the non-smoking sock 1 according to the present modification. It is possible to control. Therefore, in the non-smoking sock 1 according to this modification, the economic burden on the user is extremely small, and the continuity of non-smoking is promoted.

  Moreover, in this modification, the flexible film | membrane 28 is used as what hold | maintains the active ingredient containing body 27. FIG. Thereby, in the some flexible film | membrane 28 contained in the one elastic granular material 20, at least 1 differs among the particle size and the softness | flexibility of the flexible film | membrane 28, and each flexible film | membrane 28 from the outside is changed. It becomes possible to vary the ease of bursting against pressure. As a result, it is possible to control not only the elastic base material 22 but also the flexible film 28 to control the discharge amount of the active ingredient-containing body 27. Therefore, the discharge amount can be controlled with a high degree of freedom.

  Even if the particle diameter and softness of all the flexible films 28 included in one elastic granular body 20 are uniform, the position of the flexible film 28 in the one elastic granular body 20 and Depending on the positional relationship of the flexible membrane 28 with the passage 23, etc., it is possible to vary the ease of rupture of each flexible membrane 28 with respect to external pressure. Therefore, in this case as well, the discharge amount of the active ingredient-containing body 27 can be controlled not only by the elastic base material 22 but also by the flexible film 28 to some extent. It can be done with a degree of freedom.

[Modification 2]
In the said embodiment and the modification 1, although the some elastic granular material 20 was adhering to the cloth part 10, for example, although not shown in figure, you may adhere to clothing, such as underpants. In the case where the plurality of elastic granular materials 20 are fixed to the pants, when the user sits on a chair or the like, pressure is applied to the plurality of elastic granular materials 20 by the buttocks, and the active ingredient discharged by the pressure After the inclusion body adheres to the butt where pressure is applied to the plurality of elastic granular materials 20, it penetrates the skin of the butt and is absorbed into the body.

  Here, as well as the sole, the buttocks are not easily rubbed against not only the adhesive but also nicotine itself. Therefore, according to the sock 1 for smoking cessation according to the present modification, there is no possibility of causing a skin irritation caused not only by the adhesive but also by nicotine itself, as in the above-described embodiment and modification 1.

[Modification 3]
In the above embodiment and Modifications 1 and 2, the plurality of elastic granular bodies 20 are fixed to the cloth portion 10, but are fixed to a fibrous sheet having a flexibility made of a material different from that of the cloth portion 10. Also good.

<Second Embodiment>
(About configuration)
FIG. 8 illustrates an example of a schematic configuration of the non-smoking sheet 2 according to the second embodiment of the present invention. FIG. 9 shows an example of a state when the non-smoking sheet 2 of FIG. 8 is wound around the grip member 40. The non-smoking sheet 2 corresponds to a specific example of the “transdermal device” of the present invention.

  The smoking cessation sheet 2 is a kind of smoking cessation aids such as a nicotine patch and nicotine gum, and is used when quitting smoking while ingesting nicotine. The non-smoking sheet 2 includes a sheet-like base material 32 and a plurality of elastic granules 33. The base material 32 is constituted by a fibrous sheet having flexibility. Examples of the fibrous sheet having flexibility include a synthetic fiber sheet, a breathable sheet, a fabric, or paper. The plurality of elastic granules 33 are configured by the same structure and material as the plurality of elastic granules 20 of the above-described embodiment or its modification (see FIGS. 2A, 2B, and 6). And it is fixed to the base material 32.

  In the non-smoking sheet 2, the base material 32 is further attached to a grippable object (for example, the above-described grip member 40) on the surface of the base material 32 opposite to the surface on which the plurality of elastic granular materials 33 are fixed. And a protective film 35 that protects the adhesive layer 34 when not in use. The adhesive layer 34 has an adhesive force that allows the base material 32 to be attached to an object that can be gripped and that allows the base material 32 to be easily peeled off after using the non-smoking sheet 2. . The protective film 35 is peeled off from the non-smoking sheet 2 when the non-smoking sheet 2 is used.

(About manufacturing method)
Parts of the non-smoking sheet 2 other than the adhesive layer 34 and the protective film 35 are manufactured by replacing the cloth portion 10 with the base material 32 in the manufacturing method of the non-smoking sock 1 of the above-described embodiment and its modifications. It is possible. Therefore, first, a portion other than the adhesive layer 34 and the protective film 35 of the non-smoking sheet 2 (non-smoking sheet 2A) using the same method as the manufacturing method of the non-smoking sock 1 of the above-described embodiment and its modifications. Create Next, the adhesive layer 34 and the protective film 35 are laminated | stacked in this order on the surface on the opposite side to the surface where the some elastic granular material 33 is adhering among 2A of non-smoking sheets. In this way, the non-smoking sheet 2 of the present embodiment is manufactured.

(About effect)
In the present embodiment, the active ingredient-containing body is held by the plurality of holding means 21 or the plurality of holding means 26 as in the above embodiment. Thereby, the active ingredient containing body can be confined in a state of being finally dispersed in the elastic base material 22. Further, in the present embodiment, the plurality of holding units 21 or the plurality of holding units 26 have a structure capable of discharging the active ingredient-containing body in accordance with an external pressure. Further, a plurality of elastic base materials 22 covering the plurality of holding units 21 or the plurality of holding units 26 control the discharge amount of the active ingredient-containing body discharged from the plurality of holding units 21 or the plurality of holding units 26 to the outside. The passage 23 is formed according to the pressure from the outside. Thereby, for example, after the protective film 35 is peeled off and the smoking cessation assisting sheet 2 is attached to the grip member 40, the smoking cessation assisting sheet 2 attached to the grip member 40 is grasped by hand, thereby forming a plurality of elastic granular bodies 20. When pressure is applied to the elastic base material 22, a plurality of passages 23 are formed in the elastic base material 22 according to the pressure, and the plurality of holding means 21 or the plurality of passages 23 are formed in the elastic base material 22. The active ingredient containing bodies in the plurality of holding means 26 are discharged to the outside. The discharge amount of the active ingredient-containing body to the outside is controlled by the number and diameter of the passages 23 through which the active ingredient-containing body passes and the number, size, and shape of the elastic granules 20. For example, after the discharged active ingredient-containing body adheres to the palm of the plurality of elastic granular bodies 20 that has been pressurized, it penetrates the skin of the palm and is absorbed into the body. Thus, the smoking cessation auxiliary sheet 2 can absorb an appropriate amount of the active ingredient-containing body into the body through the skin without using an adhesive. Furthermore, the smoking cessation auxiliary sheet 2 can absorb the active ingredient-containing body into the body through the skin only by applying pressure to the plurality of elastic granular bodies 20. Thereby, while the active ingredient containing body remains in the smoking cessation assisting sheet 2, the smoking cessation assisting sheet 2 can be reused. From the above, according to the smoking cessation auxiliary sheet 2 of the present embodiment, there is no possibility of causing skin irritation caused by the adhesive, and it can be reused.

  Moreover, in this Embodiment, the site | part which absorbs an active ingredient containing body becomes a palm. Therefore, according to the smoking cessation auxiliary sheet 2 of the present embodiment, there is no possibility of causing skin irritation caused by nicotine itself as well as the adhesive. Moreover, in this Embodiment, since the some elastic granular material 20 is adhering to the fibrous sheet called the base material 32 similarly to the said embodiment, the base material 32 does not prevent skin respiration of the palm. Therefore, there is no possibility of causing skin irritation caused by obstructing skin respiration.

  In this embodiment, since the smoking cessation assisting sheet 2 can be reused, the user can appropriately control the overdose only by grasping the smoking cessation assisting sheet 2 occasionally. is there. Therefore, in the smoking cessation assistance sheet 2 of the present embodiment, the economic burden on the user is extremely small, and continuation of smoking cessation is promoted.

<Modification of Second Embodiment>
[Modification 1]
In the second embodiment, the smoking cessation assisting sheet 2 is used in a state of being wrapped around the grip member 40. For example, a contact surface (inner surface) in contact with the sole of the bottom of a general sock is used. Or you may use in the state stuck on the surface which touches skin among clothes, such as underpants.

<Modifications common to the first and second embodiments>
While the present invention has been described with reference to the embodiment and its modifications, the present invention is not limited to the above-described embodiment and the like, and various modifications can be made.

  For example, in the above-described embodiment and the like, the active ingredient-containing body contains nicotine as an active ingredient, but other substances may be contained as an active ingredient. For example, the active ingredient-containing body may contain a bottle extract as an active ingredient.

  In the above-described embodiment and the like, the non-smoking sock 1 and the non-smoking sheet 2 are provided with the plurality of elastic granular materials 20 and 33. However, if necessary, one elastic granular material 20 and 33 is provided. It may be provided. For example, as shown in FIG. 10, one elastic granular body 33 may be provided in the non-smoking sheet 2.

  In the above-described embodiment and the like, the passage 23 is formed naturally in the manufacturing process, or is formed by pressure applied when the non-smoking sock 1 or the non-smoking sheet 2 is used. Furthermore, it may be artificially formed, for example, by piercing the elastic base material 22 with a needle or the like.

  Moreover, although the case where this invention was applied to a smoking cessation aid was demonstrated in the said embodiment etc., of course, it is also possible to apply this invention to the other use. However, in that case, the active ingredient-containing body contains an active ingredient according to the application. For example, when the present invention is applied to a therapeutic device for heart disease, the active ingredient-containing body contains, for example, nitroglycerin as an active ingredient. In addition, for example, when the present invention is applied to an athlete's foot treatment tool, the active ingredient-containing body contains, for example, an anti-tinea agent as an active ingredient. In addition, for example, when the present invention is applied to a hay fever treatment device, the active ingredient-containing body contains, for example, an antihistamine as an active ingredient.

  DESCRIPTION OF SYMBOLS 1 ... Non-smoking socks, 2 ... Non-smoking sheet, 10, 10B ... Cloth part, 10A ... Opening, 11 ... Bottom part, 11A ... Contact surface, 20, 33 ... Elastic granular material, 21, 26 ... Holding means, 21A ... Particle , 22 ... elastic matrix, 23 ... passage, 24 ... liquid matrix, 25, 29, 31 ... dispersion, 27 ... active ingredient-containing body, 28 ... flexible membrane, 29A ... spherical dispersion, 29B ... solid, 29C ... crushed pieces, 30 ... solution, 32 ... base material, 34 ... adhesive layer, 35 ... protective layer, 40 ... grip member, 500, 600 ... solution tank, 510 ... hole.

Claims (14)

A substrate;
A plurality of elastic granules fixed to the substrate;
The plurality of elastic granules are
A liquid or gel material;
A plurality of holding means having a structure capable of holding the liquid substance or the gel substance inside and discharging the liquid substance or the like according to the pressure from the outside;
Elasticity that covers the plurality of holding means and that has a plurality of passages for controlling the discharge amount of the liquid substance or the gel-like substance discharged from the holding means to the outside according to the pressure from the outside A transdermal device having a base material. The transdermal device according to claim 1, wherein the base material is a fibrous sheet having flexibility. The transdermal device according to claim 2, wherein the base material is a synthetic fiber sheet, a breathable sheet, a fabric, or paper. The transdermal device according to claim 3, wherein the base material has an adhesive layer for attaching the base material to a grippable object on a surface opposite to a surface to which the plurality of elastic granular materials are fixed. device. The transdermal device according to claim 1, wherein the base material is clothing or socks. The transdermal device according to any one of claims 1 to 5, wherein the liquid substance or the gel substance contains nicotine or a bottle extract as an active ingredient. The transdermal device according to any one of claims 1 to 5, wherein the liquid substance or the gel-like substance contains nitroglycerin, an anti-tinea agent, or an anti-histamine as an active ingredient. The transdermal device according to any one of claims 1 to 5, wherein the holding means is made of a porous material. The transdermal device according to claim 8, wherein the porous material is zeolite, diatomaceous earth, a highly water-containing polymer, or a fibrous powder. The transdermal device according to any one of claims 1 to 5, wherein the holding means is formed of a flexible membrane that bends in response to pressure from the outside. The transdermal device according to any one of claims 1 to 5, wherein the elastic base material includes a one-component addition silicone, a two-component addition silicone, a rubber-based latex, or a self-crosslinking emulsion. device. A plurality of holding means for holding a liquid substance or a gel-like substance inside and discharging according to pressure from the outside are mixed with the liquid base material and stirred, whereby the plurality of holding means become fine spherical particles. Creating a dispersed dispersion; and
And placing the dispersion at a predetermined position on the surface of the substrate, and then heating the dispersion on the surface of the substrate. The holding means is made of a porous material and holds the liquid substance inside,
The method for manufacturing a transdermal device according to claim 12, wherein the liquid substance contains moisture. The holding means is made of a flexible membrane that bends in response to external pressure, and holds the gel substance inside.
The method for manufacturing a transdermal device according to claim 12, wherein the liquid base material contains moisture.

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