JP2011016729A - Aqueous external preparation for scalp - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an aqueous external preparation for scalp that improves a voluminous feeling of the hair without causing stickiness.SOLUTION: The aqueous external preparation for scalp comprises the following components (A)-(F): (A) at least one blood circulation-promoting component selected from among an extract of Swertia japonica, vitamin E's and nicotinic acids; (B) an extract of Eucalyptus globules; (C) 1×10to 1×10 mass% of an N-propionyl polyethyleneimine-methylpolysiloxane copolymer; (D) 5×10to 5 mass% of an N,N-dimethylaminoethyl methacrylate diethyl sulfate-N,N-dimethylacrylamide-polyethylene glycol dimethacrylate copolymer; (E) 2×10 to 6×10 mass% of ethanol; and (F) water.

Description

  The present invention relates to an aqueous scalp external preparation.

  Conventionally, functions expected for hair nourishing and hair-growth include hair quality improvement effects such as thinning hair, reduction of hair loss, and improvement in hair tension. However, although the hair nurturing agent described in Patent Document 1 can improve the harshness of the hair, the hair remains stiff and is insufficient for the hair quality improvement effect. Further, as in Patent Document 2, a technique for improving the stiffness is disclosed, but the stickiness is not improved. The effect of improving the immediate effect of hair quality superior to the present is desired, and an aqueous scalp external preparation (see Patent Document 3) in which the type of polymer is changed has been reported.

JP 2006-213637 A JP 2009-96765 A JP 2008-208117 A

Conventional aqueous scalp external preparations have a lot of stickiness in hair immediately after use, have no voluminous feel, and are not satisfactory.
Then, this invention provides the aqueous | water-based scalp external preparation which improves the volume feeling of hair without stickiness by combining a specific polymer.

  The present invention relates to a specific (C) N-propionylpolyethyleneimine / methylpolysiloxane co-polymerized with (A) at least one blood circulation promoting component selected from assembly extract, vitamin E, nicotinic acid and (B) eucalyptus extract. An aqueous solution containing a combination of (D) N, N-dimethylaminoethyl diethyl methacrylate methacrylate / N, N-dimethylacrylamide / polyethylene glycol dimethacrylate copolymer and further containing (E) ethanol and (F) water An external preparation for scalp is provided.

  ADVANTAGE OF THE INVENTION According to this invention, the aqueous scalp external preparation which improves the volume feeling of hair without stickiness is provided.

Embodiments of the present invention will be described below.
The aqueous scalp external preparation of this embodiment is
The following components (A) to (F):
(A) at least one blood circulation promoting component selected from assembly extract, vitamin E, and nicotinic acid;
(B) Eucalyptus extract;
(C) 1 × 10 ⁻¹ to 1 × 10 mass% of N-propionylpolyethyleneimine / methylpolysiloxane copolymer;
(D) 5 × 10 ^{−2 to} 5% by mass of N, N-dimethylaminoethyl diethyl methacrylate methacrylate / N, N-dimethylacrylamide / polyethylene glycol dimethacrylate copolymer;
(E) 2 × 10-6 × 10 mass% ethanol;
And (F) an aqueous scalp external preparation containing water is preferable. Next, each component will be described in detail.

(Ingredient (A))
Component (A) is at least one blood circulation promoting component selected from assembly extract, vitamin Es, and nicotinic acids. Specifically, assembly extract, vitamin E (DL-α-tocopherol, D-α-tocopherol, DL-α-tocopherol acetate, D-α-tocopherol acetate, etc.), nicotinic acids (nicotinic acid, DL-α- Tocopherol nicotinate, nicotinamide, benzyl nicotinate, etc.). Of these, DL-α-tocopherol acetate, nicotinic acid amide and assembly extract are preferable for promoting blood circulation of the scalp, and these can be used alone or in combination of two or more. In particular, nicotinamide and assembly extract are preferable from the viewpoint of promoting blood circulation of the scalp and contributing to hair elasticity.

The assembly extract, which is a blood circulation promoter of component (A), has a dry mass of 1 × 10 ⁻⁵ to 1% by mass, preferably 1 × 10 ⁻⁴ to 1 × 10 ⁻¹ % by mass, From the viewpoint of promoting blood circulation of the scalp, it is preferable to contain 1 × 10 ^{−3 to} 5 × 10 ⁻² mass%. Vitamin Es and nicotinic acids are 1 × 10 ^{−4 to} 3% by mass, preferably 1 × 10 ⁻³ to 1% by mass, and 1 × 10 ^{−2 to} 5 × 10 ⁻ in terms of promoting blood circulation of the scalp. It is preferable to contain ¹ mass%.

(Ingredient (B))
The eucalyptus extract of component (B) is obtained by extracting the leaves, branches, etc. of Eucalyptus globulus [scientific name: Eucalyptus globulus], which is a eucalyptus family Eucalyptus plant, as they are or by dry pulverization, solvent extraction and concentration. The extract is generally used as a moisturizer, antibacterial, antibacterial, blood circulation promotion, astringent effect and the like. Moreover, a commercial item can also be utilized. In addition, as an extraction solvent, a solvent usually used for extraction of plant components, for example, water, petroleum ether, n-hexane, toluene, dichloroethane, chloroform, ether, ethyl acetate, acetone, methanol, ethanol, propanol, butanol, Ethylene glycol, propylene glycol, butylene glycol and the like can be used, and water, ethanol, propylene glycol and butylene glycol can be preferably used. You may use these in combination of 2 or more type. Moreover, the extraction conditions can follow the extraction conditions of the conventional eucalyptus extract. For example, the above plant can be immersed in the extraction solvent at 3 to 100 ° C. for several hours to several weeks, or the extraction solvent can be heated to reflux. Can be mentioned.

Eucalyptus extract component (B), based on the whole composition, 1 × ¹⁰ -5 to 1 wt% as dry weight, preferably 1 × ¹⁰ -4 ~1 × ^{10 -1} wt%, more preferably 1 × 10 ^{- 3 to} 5 × 10 ⁻² mass%. By blending in this range, stickiness of the scalp and hair can be suppressed and the feel of hair can be prevented from being impaired.

(Ingredient (C))
The component (C) N-propionyl polyethyleneimine / methyl polysiloxane copolymer is represented by the following general formula (1).

(Wherein R ² represents C ₂ H ₅ , m represents a number of 20 to 10000, n represents a number of 20 to 10000, x and y each represents a number of 5 to 100, and Y ⁻ Represents an anion).
Examples of the anion Y ⁻ in the general formula (1) include an ethyl sulfate anion. )

  The weight average molecular weight (MWt) of the component (C) is preferably 35,000 to 130,000, and more preferably 85,000 to 120,000, because the hair does not feel sticky.

  The molecular weight (MWox) of the poly (N-propionylpolyethyleneimine) segment of component (C) refers to the number average molecular weight measured by GPC measurement method, preferably 700 to 3000, more preferably 1000 to 2800. As a result, the hair can be made smooth and have a soft finish.

  The weight average molecular weight (MWsi) of the organopolysiloxane segment constituting the main chain is 30,000 to 110,000, but preferably 80,000 to 100,000 from the viewpoint of making the hair smooth and soft. .

The weight average molecular weight is a polystyrene equivalent weight average molecular weight measured by GPC under the following conditions.
Column: Super HZ4000 + Super HZ2000 (manufactured by Tosoh Corporation)
Eluent: 1 mM triethylamine / THF
Flow rate: 0.35 mL / min
Column temperature: 40 ° C
Detector: UV
Sample: 50 μL

  The mass content of the weight average molecular weight (MWsi) of the methylpolysiloxane segment, which is the main chain in the component (C) weight average molecular weight (MWt), is 50 to 98%. can get. Of these, 80 to 95% is preferable.

The component (C) can be contained in the total composition at 1 × 10 ⁻¹ to 1 × 10 mass%. Preferably it is 1 * 10 < ^-1 > -5 mass%, Most preferably, it is 5 * 10 < ^-1 > ^-3 mass%. Further, by blending in this range, it is possible to suppress the stickiness of the scalp and hair so as not to impair the feel of the hair.

(Component (D))
The component (D) N, N-dimethylaminoethyl diethyl methacrylate methacrylate / N, N-dimethylacrylamide / polyethylene glycol dimethacrylate copolymer preferably has a molecular weight in the range of 500 to 3000. The range of 1000-2000, especially the range of 1200-1800 is preferable.

The content of the component (D) N, N-dimethylaminoethyl diethyl methacrylate methacrylate / N, N-dimethylacrylamide / polyethylene glycol dimethacrylate copolymer is preferably 5 × 10 in the total amount of the aqueous scalp external preparation. ^{−2 to} 5% by weight, preferably 1 × 10 ^{−1 to} 5% by weight, particularly preferably 3 × 10 ^{−1 to} 3% by weight. Moreover, by containing in this range, the stickiness of a scalp and hair is suppressed and it is excellent in the touch of hair.
Component (C) N-propionylpolyethyleneimine / methylpolysiloxane copolymer in aqueous scalp external preparation, component (D) N, N-dimethylaminoethyl diethyl methacrylate sulfate, N, N-dimethylacrylamide, The content ratio of the polyethylene glycol dimethacrylate copolymer is preferably (C) / (D) = 1/2 to 10/1 by mass ratio. Above all, by setting the mass ratio to (C) / (D) = 1/1 to 5/1, these components can be found at the base of the hair that grows from the scalp whose blood circulation is promoted by the components (A) and (B). Since it absorbs and acts as a cushion, the effect of raising the hair from the root is obtained, and as a result, it is possible to make the hair supple and voluminous.

(Ingredient (E))
Content of ethanol of a component (E) is 2 * 10-6 * 10 mass% in the whole composition.
More preferably, it is 3 * 10-5.5 * 10 mass%.

(Ingredient (F))
The water content of the component (F) is preferably 3 × 10 to 7.5 × 10 mass%, more preferably 4 × 10 to 7.3 × 10 mass% in the entire composition.

The aqueous scalp external preparation of the present invention can further contain a component (G) flavonols. As the flavonols, any of the synthetic flavonols described in JP-A-8-157464 or JP-A-8-157334 can be used. Of these, trans-3,4′-dimethyl-3-hydroxyflavanone is particularly preferable. Flavanols can be contained in at least one or two or more. Content in the whole composition is preferably from 1 × ¹⁰ -3 to 2 wt% from the viewpoint of improvement of the hair growth effects and healthy scalp, inter alia 5 × ¹⁰ -3 to 1 wt%, especially 1 × 10 ^{- 2} to 8 × ^{10 -1%} by mass.

The aqueous scalp external preparation of the present invention further contains at least one or two or more components (H) glycyrrhetinic acid, glycyrrhizic acid, dipotassium glycyrrhizinate, and stearyl glycyrrhetinate from the aspect of improving the healthy scalp. Can do. The content in the total composition is preferably 1 × 10 ^{−4 to} 5% by mass, particularly 5 × 10 ⁻³ to 1% by mass, particularly 1 × 10 ^{−2 to} 5%, from the viewpoint of the effect of improving healthy scalp. × 10 ⁻¹ mass% is preferable.

The aqueous scalp external preparation of the present invention further contains an antibacterial agent, hair follicle activator, moisturizer, keratolytic agent, antiseborrheic agent, local stimulant, antiandrogen, potassium channel opener and One or more components selected from antioxidants can be blended. These components are contained in the aqueous scalp external preparation of the present invention in an amount of 1 × 10 ^{−3 to} 3 × 10 mass%, preferably 1 × 10 ^{−2 to} 1.5 × 10 mass%.

  Examples of the antibacterial agent include isopropylmethylphenol, benzalkonium chloride, octopirox, photosensitive dye 101, photosensitive dye 201, chlorhexidine, salicylic acid, zinc pyrithione, potassium sorbate, hinokitiol, phenol and the like. Of these, isopropylmethylphenol, benzalkonium chloride, octopirox, zinc pyrithione, hinokitiol and the like are particularly preferable.

  Examples of hair follicle activators include trans-3,4'-dimethyl-3-hydroxyflavanone, adenosine, pantothenyl ethyl ether, cytopurine, N-acetyl-L-methionine, Tamazaki kurafuji, cephalanthin, adenosine triphosphate Disodium, potassium aspartate, photosensitive dye 301, pentadecanoic acid glyceride, ethyl pantothenate, chixet carrot, biotin, mononitroguaiacol sodium, yeast extract, garlic component, pearl protein extract, tiso extract, placenta extract, royal jelly, sophora Examples include extraction paste (kudin), 6-benzylaminopurine, dialkyl monoamine derivatives, and the like. Among these, particularly Japanese cypress rafji, cephalanthin, adenosine triphosphate disodium, pentadecane glyceride, ethyl pantothenate, chixetsuninjin, biotin, sodium mononitroguaiacol, placenta extract, royal jelly and the like.

  Examples of the moisturizing agent include hypericum extract, oat extract, soluble collagen, glycerin, chondroitin sulfate, tuberose polysaccharide, propylene glycol, cordyceps extract, life-grass extract, barley extract, orange extract, grape extract, seaweed extract, button pi extract , Jiou extract, Duke extract, Maikai flower extract, Yokuinin extract, Panax ginseng extract, Delamide, Altea extract, Kuchachararate extract, Japanese spinach extract, Coriander extract, Salamander extract, Achacha extract, Hop extract, etc. It is done. Among these, especially Hypericum extract, Oat extract, Glycerin, Tuberose polysaccharide, Cordyceps extract, Life-extending grass extract, Barley extract, Grape extract, Seaweed extract, Potampi extract, Diou extract, Duke extract, Maikai flower extract, Yakuinin extract, etc. Can be mentioned.

  Examples of the keratolytic agent include aspirin. Examples of antiseborrheic agents include sulfur, lecithin, cachet extract, and thioxolone.

  Examples of the local stimulant include camphor, capsicum tincture, l-menthol, nonyl acid vanillylamide, ginger tincture, Dutch pepper, cantalis tincture, salamander extract, peppermint oil, horseradish radish extract and the like. Examples of anti-androgenic agents include cyproterone acetate, 11α-hydroxyprogesterone, flutamide, 3-deoxyadenosine, chlormadinone acetate, ethinyl estradiol, spironolactone, epitesterone, aloe, salamander, ginseng and the like.

  Examples of the potassium channel opener include minoxidil, chroma potassium, diazoxide and derivatives thereof, pinacidil and the like.

  Examples of the antioxidant include black tea extract, tea extract, clove extract, age extract, jaundice extract, vitamin C and its derivatives, erythorbic acid, propyl gallate, dibutylhydroxytoluene and the like.

The aqueous scalp external preparation of the present invention further contains one or more surfactants selected from nonionic surfactants, cationic surfactants, anionic surfactants and amphoteric surfactants. Can do. Such a surfactant is not particularly limited as long as it is used in ordinary cosmetics and the like. For example, nonionic surfactants include polyoxyethylene alkyl ether, polyoxyethylene alkyl allyl ether, polyoxyethylene. Derivatives, polyoxyethylene fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitol fatty acid esters, and the like. Examples of cationic surfactants include tertiary amine salts, And the like. Examples of the anionic surfactant include lauryl sulfate and polyoxyethylene lauryl ether sulfate. Examples of the amphoteric surfactant include alkyl betaine and amine oxide. . These components are 5 * 10 < ^-3 > ^-2 * 10 mass% in the whole composition, More preferably, they are 1 * 10 ^<-2 > ^-1 * 10 mass%.

  The aqueous scalp external preparation of the present invention can be produced according to a usual method, for example, it can be produced by uniformly mixing the aforementioned components (A) to (F) and other components according to a conventional method. it can. Also, component (D), component (E), and component (G) are mixed and dissolved, and components (A), (B), (C), (F), (H) and other components are added. , Mixed and dissolved.

  The aqueous scalp external preparation of the present invention can be used as cosmetics, pharmaceuticals, quasi drugs, etc., depending on other additives and dosage forms to be blended. Here, the dosage form is not particularly limited as long as the aqueous scalp external preparation of the present invention can be applied to the scalp, and for example, a dosage form such as lotion, tonic, cream, gel, foam, spray, aerosol, etc. be able to. Moreover, when setting it as the aerosol agent containing a propellant, as a propellant, carbon dioxide gas, LPG, dimethyl ether, nitrogen gas, isopentane, nitrous oxide etc. are mentioned, for example, These are 1 type or in combination of 2 or more types. Can be used. As the propellant, carbon dioxide gas is particularly preferable from the viewpoint of usability.

  The method for using the aqueous scalp external preparation of the present invention is not particularly limited as long as the aqueous scalp external preparation adheres to the scalp.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated further more concretely, this invention is not limited to these Examples.

N-propionylpolyethyleneimine / methylpolysiloxane copolymers C1 and C2 as the component (C) used in Table 1 were produced by the following method.
(Method for producing C1)
Poly (N-propionylethyleneimine) having a number average molecular weight of 2700 was obtained from 0.8 g (0.005 mol) of diethyl sulfate, 12.8 g (0.14 mol) of 2-ethyl-2-oxazoline and 29 g of dehydrated ethyl acetate. Obtained. Further, 100 g of side chain primary aminopropyl-modified polydimethylsiloxane (weight average molecular weight 100000, amine equivalent 20000) was used to convert N-propionylethyleneimine-dimethylsiloxane copolymer into a pale yellow rubber-like solid (111 g, yield 98%). ). The content of the organopolysiloxane segment in the final product was 88% by mass, and the weight average molecular weight was 114,000. As a result of neutralization titration with hydrochloric acid using methanol as a solvent, it was found that no amino group remained.

(Method for producing C2)
In the same manner as C1, 6.5 g (0.042 mol) of diethyl sulfate, 34.4 g (0.36 mol) of 2-ethyl-2-oxazoline, and 87 g of dehydrated ethyl acetate were used to obtain a poly ( N-propionylethyleneimine) was obtained. Further, 100 g of side chain primary aminopropyl-modified polydimethylsiloxane (weight average molecular weight 32000, amine equivalent 2000) was used to convert N-propionylethyleneimine-dimethylsiloxane copolymer into a pale yellow rubber-like semisolid (138 g, yield 98). %). The final product had an organopolysiloxane segment content of 71% by mass and a weight average molecular weight of 46,000. As a result of neutralization titration with hydrochloric acid using methanol as a solvent, it was found that about 22% by mass of amino groups remained.

  Table 1 shows the physical properties of the N-propionyl polyethyleneimine / methyl polysiloxane copolymers C1 and C2 used in this example.

MWsi / MWt: Content of organopolysiloxane segment (MWsi) in the total weight of N-propionylpolyethyleneimine / methylpolysiloxane copolymer MWsi: Weight average molecular weight of organopolysiloxane segment constituting main chain MWox: Poly ( N-propionylpolyethyleneimine) segment number average molecular weight MWt: N-propionylpolyethyleneimine / methylpolysiloxane copolymer weight average molecular weight

The component (D1) used in Table 1 was produced by the following method.
(Method for producing D1)

<Production Example 1 of cationic group-containing copolymer>
In a 1 L beaker, 267.4 g of ion-exchanged water, MOEDES (Equimolar adduct of dimethylaminoethyl methacrylate and dimethylsulfate (effective content 80% by weight), both reagents, Wako Pure Chemical Industries, Ltd.) 185.63 g (effective 148.50 g), DMAAm (N, N-dimethylacrylamide, reagent, manufactured by Wako Pure Chemical Industries, Ltd.) 110.46 g, NK-14G (crosslinking agent, polyethylene glycol dimethacrylate, manufactured by Shin-Nakamura Chemical Co., Ltd.) 0.415 g, V-50 (polymerization initiator, 2,2 &apos; -azobis (2-amidinopropane) .dihydrochloride, manufactured by Wako Pure Chemical Industries, Ltd.) 0.952 g were mixed to obtain an aqueous monomer solution A. . Into a 5 L glass container, 1648 g of cyclohexane and 1.94 g of sugar ester S-770 (manufactured by Mitsubishi Kasei Co., Ltd.) as a dispersant were charged and dissolved uniformly at 60 ° C. over 1 hour. After dissolution, the mixture was cooled to 30 ° C. to obtain Dispersant Solution B.

  The monomer aqueous solution A is added to the dispersant solution B, set in a homomixer (ROBOMICS, manufactured by Tokki Kika Kogyo Co., Ltd.), and stirred at 9000 rpm for 4 minutes to obtain a monomer dispersion having an average particle size of 5 μm. . The whole amount was charged into a 5 L SUS tank equipped with a stirrer, a thermometer and a cooling tube, purged with nitrogen, heated, and polymerized at 55 ° C for 1 hour. Further, after aging at 70 ° C. for 1 hour, a dehydrating tube with a cooling tube was attached, and 269 g of water was removed from the system over about 2 hours. As dehydration progressed, the temperature in the tank increased from 70 ° C to 90 ° C.

  Subsequently, it was cooled to 40 ° C. or lower, and the contents were transferred to a stainless steel tray and dried with hot air at 80 ° C. to remove the solvent, thereby obtaining a white / granular cationic group-containing copolymer 1. The cationic group-containing copolymer 1 used in the examples was lightly pulverized in a household coffee mill for about 1 second to obtain a cationic group-containing copolymer D1 having an average particle size of 4.0 μm.

In Table 2, the assembly extract and eucalyptus extract are shown based on the content in a commercially available solution state. In the case of the dry weight of the assembly extract, in the case of a commercially available product, for example, (Ichimaru Falcos) raw material name: Srutianin, the dry weight is 0.9 to 1.1% by mass. Moreover, in the case of the dry mass of a eucalyptus extract, in a commercial item, for example (Maruzen Pharmaceutical Co., Ltd.) raw material name: Eucalyptus extract BG-KA, it is a dry residue: 0.15-0.25 mass%.
Here, the dry mass is obtained as a ratio (mass%) of 10 ml of the extract at 105 ° C. for 6 hours and dried to the 10 ml of the extract.

(Examples 1-8 and Comparative Examples 1-3)
The components (D), (E), and (G) having the composition shown in Table 2 are mixed and dissolved, and the components (A), (B), (C), (F), (H) and other components are mixed. Was added and mixed and dissolved to prepare an aqueous scalp external preparation. In Table 2, the unit of component content is mass%. From Example 1 and Comparative Examples 1, 2, 3, and Example 3 and Comparative Examples 1, 2, 3, the combination of the component (C) and the component (D) gives the hair firmness, suppleness, and volume. It turns out that it becomes remarkable.

Each aqueous scalp preparation 1 g thus obtained was applied to a scalp portion about 10 cm square twice a day for 10 subjects and compared with the start time. Evaluation items are: no stickiness immediately after application, sharpness of hair immediately after application, light smoothness of hair immediately after application, suppleness of hair immediately after application, volume of hair immediately after application, and volume of hair for 2 weeks after application. Two skilled evaluators evaluated the following 1 to 5 points by visual inspection and palpation. The obtained results are shown in Table 2.
Determined to be effective by 9 or more people: 5
7, 8 or more people judged to be effective: 4
5 or 6 people judged to have effect: 3
3 and 4 people are judged to be effective: 2
2 or less people judged to be effective: 1

Example 9
Components (D), (E), and (G) having the composition shown in Table 3 are mixed and dissolved, and components (A), (B), (C), (F), (H), and other components are mixed. To obtain a lotion stock solution. 97.5 g of this lotion and 2.5 g of carbon dioxide were each filled into an aerosol container to prepare an aerosol type hair restorer. In Table 3, the unit of content of components is mass%.

Claims (5)

The following components (A) to (F):
(A) at least one blood circulation promoting component selected from assembly extract, vitamin E, and nicotinic acid;
(B) Eucalyptus extract;
(C) 1 × 10 ⁻¹ to 1 × 10 mass% of N-propionylpolyethyleneimine / methylpolysiloxane copolymer;
(D) 5 × 10 ^{−2 to} 5% by mass of N, N-dimethylaminoethyl diethyl methacrylate methacrylate / N, N-dimethylacrylamide / polyethylene glycol dimethacrylate copolymer;
(E) 2 × 10-6 × 10 mass% ethanol;
And (F) an aqueous scalp preparation containing water.   The N-propionyl polyethyleneimine / methyl polysiloxane copolymer of the component (C) has a weight average molecular weight of 35,000 to 130,000, and the mass content of methyl polysiloxane as a main chain is 50 to 98%. Aqueous scalp preparation.   The aqueous scalp external preparation according to claim 1 or 2, wherein a content ratio of the component (C) to the component (D) is (C) / (D) = 1/2 to 10/1 in terms of mass ratio.   Furthermore, the aqueous | water-based scalp external preparation in any one of Claims 1 thru | or 3 containing (G) flavononols.   5. The composition according to claim 1, further comprising (H) at least one anti-inflammatory agent selected from glycyrrhetinic acid, glycyrrhizic acid, dipotassium glycyrrhizinate, and stearyl glycyrrhetinate at 0.001 to 1% by mass. Aqueous scalp external preparation.