JP2011010968A - Biological light measuring instrument - Google Patents

Abstract

PROBLEM TO BE SOLVED: To establish more effective technique for inputting or recognizing subject identification information since there is a problem that the input work of the subject identification information by a measuring person in biological light measurement brings complication when biological information of multiple subjects is obtained, so as to increase difficulty in information management and also to generate the risk of an input mistake.SOLUTION: An optical attenuation and absorbance, obtained by a biological light measuring instrument are compared with one kind of or a plurality of kinds of previously preserved subject information, thereby the optimum subject identification information is selected and the selected identification information is displayed in a display means.

Description

The present invention relates to an apparatus for measuring information inside a living body using light.

Devices that measure information inside a living body simply and without harming the living body are used in fields such as clinical medicine and brain science. Among them, the measurement method using light is a very effective means. The first reason is that the oxygen metabolism function in the living body corresponds to the concentration of specific pigments (hemoglobin, cytochrome aa ₃ , myoglobin, etc.) in the living body, and the concentration of these pigments is obtained from the amount of light absorption. Because it is. In addition, the second and third reasons that optical measurement is effective include that light is easy to handle with an optical fiber, and that it does not harm a living body when used within the range of safety standards.

  Taking advantage of such optical measurement, a biological optical measurement device that measures the inside of a living body using a plurality of lights having wavelengths from visible to infrared to form a two-dimensional image is disclosed in Patent Document 1 or Patent Document 2, for example. Are listed. The living body light measuring devices described in these documents generate light by a semiconductor laser, guide the generated light through an optical fiber, irradiate a plurality of locations on the subject's head, and transmit or reflect light inside the living body. Is detected at a plurality of locations, and the detected light is guided to a photodiode by an optical fiber, and biological information such as blood circulation, hemodynamics, and hemoglobin concentration change is converted into a two-dimensional image from the detected light amount.

JP-A-9-98972 JP-A-9-149903

In biological light measurement, biological information of changes in specific pigment concentration in the living body, such as changes in hemoglobin concentration, can be obtained by measuring changes in the detected light amount.
At that time, when handling such information, it is indispensable to store the biological information together with the identification information of the target subject. In particular, when observing the progress of biological information over a long period of time, it is necessary to read and input the identification information of the subject every measurement.

  Usually, subject identification information (subject ID) is manually input by a measurer using an input device such as a computer keyboard or mouse. However, the task of inputting the identification information of the subject by the measurer is troublesome in the case where the biological information of a large number of subjects is acquired, increasing the difficulty of information management, and also causing the risk of an input error. there were.

  In addition, even when information is input by an individual subject, authentication via manual input is difficult if the subject ID is forgotten or a patient who is difficult to input is targeted.

  Although biometric authentication technology that identifies the person by hand, fingerprint, iris, etc. without manual input is known, a separate device must be provided, the configuration becomes complicated, and the cost increases. there were.

  In order to cope with this problem, it has been a challenge to establish a more effective input or recognition technique for identifying the subject.

  In order to solve the above problems, one or more light irradiating means for irradiating a subject with light, one or more light detecting means for detecting light transmitted or reflected inside the subject, Information for calculating the intensity of light detected from the output value of the light detection means, and calculating the light attenuation and absorbance in the subject, which is the ratio of the intensity of the detected light to the intensity of light irradiated on the subject. A processing means and a storage means, the intensity of the light irradiated to the subject, the intensity of the light transmitted or reflected inside the subject, and the light attenuation and absorbance calculated by the information processing means, Provided is an optical measurement device that compares one or a plurality of object information stored in advance in a storage unit and displays the comparison result on the display unit.

  According to the biological light measurement device of the present invention, it is possible to select optimal subject information from the light attenuation amount and absorbance of the biological body.

1 is a schematic diagram of a biological light measurement device according to the present invention. The flowchart which shows the procedure which selects and displays test subject ID. The flowchart which shows an example of the procedure which selects optimal test subject ID. The flowchart which shows an example of a procedure when the optimal subject ID does not exist in a database. The flowchart which shows an example of the procedure which displays the candidate of test subject ID. The flowchart which shows an example of the procedure which adjusts irradiation light quantity so that detection light quantity is made constant, and selects the optimal test subject ID. The figure which shows an example of the table | surface of test subject information. The figure which shows an example which displays the selected optimal test subject ID. The figure which shows an example which displays the candidate of test subject ID in the optimal order. The figure which shows an example of a display when other than the optimal candidate of test subject ID is selected. The figure which shows an example which added the number which shows the kind of subject, and the time change of the test subject's light transmittance change with respect to this subject to the subject information table. The figure which showed an example of the table which shows matching of a task number and task content. The figure which shows an example of a subject presentation screen. The figure which shows an example of a subject presentation screen. The flowchart which shows an example which calculates | requires the pigment density | concentration change with respect to a subject, calculates a correlation coefficient with the pigment density | concentration change obtained from a database, and displays it as a coincidence degree. The figure which shows an example which displays selected subject ID and a coincidence degree. The figure which shows the external appearance of the apparatus structure which comprised the light irradiation part and the photon detection part in the cap which a test subject wears without using an optical fiber. The figure which shows the external appearance of the apparatus structure which comprised the light irradiation part and the photon detection part in the cap which a test subject wears without using an optical fiber. The figure which shows the light absorbency measurement result in 22 head parts of 5 test subjects. The figure which shows the result which normalized the result shown in FIG. 17 in each measurement location. The figure which shows a series of subjects authentication, a subject selection, a subject presentation, and a biometric measurement result. (A) As a result of subject authentication, No. The figure which shows an example which 0008 was selected and this was displayed on the display apparatus. (B) The figure which shows an example which selected the spatial WM task as a task appropriate for the selected subject ID and displayed the name of the task on the display device based on (a). (C) The figure which shows an example which displayed the selected spatial WM subject on the display apparatus. (D) The figure which shows an example of the result of having analyzed the test subject's biometric information with respect to the subject displayed by (c). The figure which shows an example which displays the screen which asks whether it is a new user on a display apparatus. The figure which shows an example which displays on the display apparatus that the said test subject is registered as a new user. The figure which shows an example which displays on a display apparatus that there exists a possibility that the light irradiation part and the light detection part are not mounted | worn or cannot be mounted | worn. The figure which shows an example of the structure which manages subject identification information collectively by one memory | storage device using two caps among the structures using two or more easy mounting caps which consist of a light irradiation part and a light detection part. The figure which shows an example of the display of a display apparatus at the time of applying the biological light measuring device by this invention to a game. The figure which shows an example of the display of a display apparatus at the time of applying the biological light measuring device by this invention to a game.

  DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

In order to solve the above problems, attention was paid to light transmittance in biological light measurement.
Patent Documents 1 and 2 exemplify a biological light measurement device that irradiates light at a plurality of locations on a subject's head, transmits or reflects the inside of the living body, and detects blood circulation, hemodynamics, Biological information such as hemoglobin concentration change is converted into a two-dimensional image. At this time, each detected light amount varies depending on the light transmittance at each measurement location. On the other hand, among the light transmittances in the living tissue, the light transmittance of the head in particular varies depending on the hemodynamics associated with brain activity, respiration, blood pressure, etc., but the amount of change is at most several percent.

Here, when the light transmittance T was repeatedly measured at a plurality of locations on the head and the absorbance A = log ₁₀ (1 / T) was determined at each location, the variation in absorbance A was found at 80% or more of the total measurement locations. It was found to be within 10%. The results are shown in FIG. 17 and FIG. FIG. 17 shows a case in which the distance between the light irradiation point and the light detection point is 30 mm, and the absorbance A at all 22 locations is 5 persons in a configuration that detects light transmitted or reflected through a plurality of biological tissues such as the scalp, skull, and cerebral cortex. It is the result measured from the subject. Absorbance is measured 5 times and error bars are standard deviations. FIG. 17 shows that the obtained absorbance varies depending on each measurement location and each subject. FIG. 18 is a graph in which each absorbance in FIG. From FIG. 2, it was found that error bars were less than 10% at 18 or more measurement locations among all 22 normalized absorbances of all subjects.

  The head is composed of a complex structure composed of a plurality of biological tissues such as the scalp, skull, and cerebral cortex. Since these structures have large individual differences, the light transmittance T and the absorbance A are large among individuals (FIG. 17). It was found that the light transmittance T and the absorbance A were measured with good reproducibility at each measurement location of a specific individual (FIG. 18).

Therefore, a first embodiment of the biological optical measurement device according to the present invention, which uses the above knowledge and images biological information such as hemodynamics in the living body, will be described.
FIG. 1 is a diagram showing a first embodiment of the present invention. The information processing apparatus 301 reads the irradiation light amount data stored in the storage device 401 through the cable 902 and sends it to the apparatus main body 100 through the cable 901. A light source control signal generated by the circuit 1001 under the control of the CPU 1000 inside the apparatus main body 100 is sent to the light source driving devices 1031 and 1032.

  The light source driving devices 1031 and 1032 cause the light emitting elements 101 and 102 to emit light based on the light source control signal. Here, the light emitting elements 101 and 102 are laser diodes, LEDs, surface emitting lasers, or the like.

Light emitted from the light emitting elements 101 and 102 is irradiated to the subject 1 by the light irradiation units 1011 and 1012 through the optical fiber 905, respectively. Light transmitted or reflected inside the subject 1 is collected by the light detection units 2011 and 2012, and transmitted to the light receiving elements 201 and 202 through the optical fiber 905, respectively.
Here, an example in which light is transmitted to the light receiving element using the optical fiber 905 has been described, but the present invention can also be realized in a form in which no optical fiber is used as shown in FIGS.
FIGS. 16A and 16B show examples of the biological light measurement device 1601 configured without using the optical fiber 905 in the biological light measurement device of FIG.
In FIG. 16A, the appearance of the biological light measurement device 1601 and the lower figure show the inner surface of the biological light measurement device 1601. On the other hand, in FIG. 16B, the upper diagram shows the appearance of the biological light measurement device 1701, and the lower diagram shows the inner surface of 17011 that is a part of the biological light measurement device 1701. Since no optical fiber is used, the light source element 101 and the light receiving element 201 in FIG. 1 correspond to the light irradiation unit 1011 and the light detection unit 2011, respectively.

  Next, light received by the light receiving elements 201 and 202 is photoelectrically converted and amplified by gains 1041 and 1042, respectively. Thereafter, the amplified optical signal is converted into a digital signal by analog-digital converters (A / D converters) 1051 and 1042 and sent to the circuit 1002.

  Here, the gains 1041 and 1042 are set to appropriate values by the CPU 1000 in consideration of the resolution of the A / D converters 1051 and 1052. The digital signal is sent to the information processing device 301 through the cable 901 together with the gain 1041 and 1042 data, and the detected light amount is calculated based on the gain 1041 and 1042 data and the sensitivity information of the light receiving elements 201 and 202.

  The information processing apparatus 301 includes an authentication unit 3011, a task presentation unit 3012, and a biological information analysis unit 3013 inside. The authentication unit 3011 selects the optimum subject identification information based on the calculated detected light amount and compares it with the subject information database stored in the storage device 401 by the comparison method described later. Displayed on the display device 501 as shown in FIG. The authentication unit 3011 selects a task suitable for the selected subject identification information from the tasks stored in the storage device 401, and displays the task name on the display device 501 as shown in FIG. . Following this, the biological information analysis unit 3013 starts to acquire the biological information of the subject, and the task presentation unit 3012 presents the task to the display device 501 as shown in FIG. 19C, for example. After completing the task presentation and the acquisition of the biological information of the subject, the biological information analysis unit 3013 analyzes the biological information of the subject with respect to the task presented to the subject, and the result is displayed on the display device 501 as shown in FIG. indicate. Further, the biological information analysis unit 3013 stores the analysis result of the biological information in the storage device 401.

  With the above configuration, the biological light measurement device according to the present invention selects the subject identification information of the subject, selects a subject appropriate for the subject, and acquires, analyzes, and displays biological information such as the subject's hemodynamics for the subject. A series of biological light measurement until storage is automatically performed.

  Hereinafter, a method for selecting subject identification information will be described in detail.

FIG. 2 is a flowchart showing the procedure of the present embodiment, excluding the procedure from reading the irradiation light amount to calculating the detected light amount. The authentication unit 3011 calculates the light transmittance T = irradiation light amount / detected light amount in step S203 from the irradiation light amount read in step S201 and the detected light amount calculated in step S202, and the absorbance A = log ₁₀ ( 1 / T). The storage device 401 stores a database as shown in FIG.
In this database, the irradiation light quantity at each measurement point and each wavelength, the detected light quantity measured in advance at each measurement point, the light transmittance, and the absorbance are recorded for each subject, and FIG. 6 shows each of the N measurement points. The data which recorded the data measured with the light of 2 wavelengths is shown.

  In step S205, the authentication unit 3011 compares the calculated absorbance A at each measurement point with the absorbance in the database, selects an optimal subject in step S206, and displays it on the display device 501 through the cable 903. An example of display on the display device 501 is shown in FIG. FIG. 7 is an example in which the number “0008” of the identification information of the subject is selected as the optimal one.

  FIG. 3A shows an example of a specific procedure for comparing in step S205 and selecting an optimal subject in S206. In step S2061, the difference between the absorbance A calculated at each measurement point and the absorbance at each measurement point of each subject in the database is obtained, and the square average of all measurement points is calculated for each subject. In step S2062, the authentication unit 3011 selects a subject having a square average indicating the minimum value among the square average values of each subject as an optimal subject in the database, and in step 2063 displays identification information of the subject on the display device 501. Is displayed as shown in FIG.

  On the other hand, there is a possibility that the optimum information cannot be selected from the subject identification information stored in the database of the storage device 401. FIG. 3B shows a flowchart when the optimum subject identification information cannot be selected. Step S <b> 2067 is a step of performing a mismatch determination between the absorbance measured by the authentication unit 3011 and the subject identification information stored in the database of the storage device 401. Here, inconsistency determination is issued when the value of the square average calculated by the authentication unit 3011 is large for any subject. For example, when the average value of all measurement points of the subject's absorbance is calculated, and the square average value is equal to or greater than the average value, that is, the absorbance recorded in the database of the storage device 401 and the subject's absorbance. A discrepancy judgment is given when a difference of 2 times or more is observed in the absorbance. If it is determined that there is a discrepancy, in step S2068, in order to confirm whether or not the subject is a new subject that is not registered in the database of the storage device 401, a display such as that shown in FIG. If YES is selected here, in step S2069a, for example, it is displayed on the display device 501 as shown in FIG. 21, and the absorbance data is stored in the database of the storage device 401 as a new subject. Further, when NO is selected in step S2068, for example, it is displayed on the display device 501 as shown in FIG. 22, indicating that the light irradiation unit and the light detection unit are not attached or are not firmly attached.

  Next, a second embodiment of the biological light measurement device according to the present invention will be described. FIG. 4 shows a flowchart of a method for sequentially displaying a plurality of candidates for the identification information of the optimum subject in place of FIG. After step S2061, in step S2065, candidate ranks for subject identification division are determined in order from the smallest square average value.

  In step S2066, the subject identification information is displayed on the display device 501 in the order of the candidate ranks. An example of the display at this time is shown in FIG. Here, the 1st to 5th candidate ranks are shown. A subject identification number is displayed for each candidate rank, and a button for selecting which identification number corresponds is displayed. Here, when the first place is selected, the information processing apparatus 301 recognizes the first place identification number, but when the second place or later is selected, a confirmation screen as shown in FIG. indicate. The confirmation screen indicates that the first subject identification number has not been selected, and the data measured this time (the read irradiation light amount, the measured detected light amount, the light transmittance, and the absorbance) are stored in the database. A message asking whether or not to reflect, and YES and NO buttons are displayed. When YES is selected, the data measured this time is reflected instead of the data recorded in the database. When NO is selected, the identification number selected in FIG. 8 is recognized without changing the stored data.

  Next, a third embodiment of the biological light measurement device according to the present invention will be described. In Examples 1 and 2, an example in which the detected light amount at each measurement point is obtained with respect to a constant irradiation light amount is shown, but in this embodiment, the irradiation light amount is adjusted so that the detected light amount is constant as shown in FIG. After that, a flowchart for selecting the optimal subject identification information based on the absorbance is shown. The detected light amount is obtained in step S502 with respect to the irradiation light amount read in step S501, and the light transmittance is calculated in step S503. Here, a certain value of the detected light quantity is introduced. This may be a value of the detected light quantity specified in advance or a value such as an average value, maximum value, minimum value, etc. of the detected light quantity obtained in step S502. When the value of the constant detected light amount is divided by the light transmittance obtained in step S503, the intensity of light to be irradiated with respect to the constant detected light amount is obtained, and this is set as the irradiated light amount (step S504). In step S505, the absorbance is obtained, compared with the absorbance in the database in step S506, the optimum subject identification information is selected in the same manner as in the first and second embodiments, and the optimum subject identification information is displayed in step S507. Further, the value of the irradiation light amount and the constant detected light amount set in step S504 are reflected in the database (step 508). In this embodiment, by storing the irradiation light amount with a constant detection light amount, the signal-to-noise ratio can be obtained regardless of the variation in light transmittance at each measurement point by using this irradiation light amount for the next light measurement. It becomes possible to make it almost constant.

  Next, a fourth embodiment of the biological light measurement device according to the present invention will be described. FIG. 10 shows an example in which the task number presented to the subject by the display device 501 and the temporal change (time-series data) of the detected light quantity when presenting this task are added to the database of the storage device 401 and recorded. Show.

The task number in FIG. 10 has a table associated with the task content as shown in FIG. 11, and this table is stored in the storage device 401. After selecting an optimal subject by the procedure of S201 to S206 of FIG. 2, or S501 to S505 of FIG. 3 or FIG. 5, a screen as shown in FIG. 12 is presented on the display device 501. Here, it is assumed that the table of FIG. 10 and FIG. 11 is followed, and the task presentation unit 3012 presents the task number T0003 “Spatial Working Memory 1” as the task to the subject selected here (FIG. 13). The analysis unit 3013 measures a temporal change in the light transmittance at this time, and stores the measurement result in the storage device 401. Based on the measurement result, according to the flowchart shown in FIG. 14, the temporal change C ₁ (t) of the dye concentration with respect to the problem is obtained in step S1401. Next, in step S1402, a temporal change C ₂ (t) in the dye concentration is obtained from a time-series change in light transmittance stored in the database. Subsequently, in step S1403, a correlation coefficient between C ₁ (t) and C ₂ (t) is calculated. Thereafter, the degree of coincidence of the subject based on the correlation coefficient is obtained and displayed on the display device 501 (step S1404). FIG. 15 shows an example of the display at this time. The degree of coincidence when the correlation coefficient between C ₁ (t) and C ₂ (t) is 0.903 is set to “90.3%”, and the absorbance measurement is performed. The identification number “0001” of the subject selected by the above and the degree of coincidence “90.3%” of the pigment concentration change when the subject set for this identification number is presented. As described above, in addition to the absorbance value at each measurement point based on the structure information of the subject, more robust subject authentication is achieved by using the degree of coincidence of changes in pigment concentration in the body with respect to tasks that are functional changes of the subject. can do.

  On the other hand, it is assumed that the change in the pigment concentration with respect to the task becomes smaller as the subject gets used to the task. For example, if the same task is performed every day, there is a possibility that a change in the dye concentration that reacts to the task cannot be obtained sufficiently. In this case, it is necessary to change the change in the pigment concentration, which is a reference for determining the degree of coincidence, according to the familiarity with the task. Here, all the data of the dye density change stored in the storage device 401 are stored, and are stored together with the measured date and time. When the measurement of the pigment concentration change for the subject's task is completed, the biological information analysis unit 3013 refers to the date and time of the previous data for the same task. If the period between the previous date and time and the measurement date and time is less than 14 days, the effect of getting used to the task is strong, and the degree of coincidence is determined based on the latest data among the past dye density change data stored in the storage device 401. calculate. In the case of 14 days or more and less than 28 days, it is assumed that the effect of habituation is weakening, and an average value at each measurement point of past dye density change data stored in the storage device 401 is calculated, and this average value is used as a reference. The degree of coincidence is calculated as follows. In the case of 28 days or more, it is determined that the effect of habituation can be ignored, and the degree of coincidence is calculated based on the first dye density change data among the past data stored in the storage device 401.

  Next, a fifth embodiment of the biological light measurement device according to the present invention will be described. In the present embodiment, it is assumed that a large number of brain function observation data of a dementia patient is acquired at a day care center or a day service center. Although it is necessary to input or authenticate subject information for data acquisition, it is difficult for a dementia patient who is a subject to input his / her subject information. When the biological light measurement device according to the present invention is used, the subject can set the light irradiation unit and the light detection unit of the biological light measurement device shown in FIG. 1 or the easy wearing type as shown in FIGS. It is possible to recognize the identification information of the subject by the methods shown in Examples 1 to 4 simply by wearing the cap, and it is possible to easily obtain the brain function observation data of a large number of subjects.

  In addition, a large number of data can be acquired at such facilities by installing a plurality of easy-mounting caps as shown in FIGS. 16A and 16B so that users of the facility can play a game between rehabilitations. It is assumed that data is acquired with a sense. In such a case, the facility user needs to recognize the identification information of the subject regardless of which cap among the plurality of caps is worn, and needs to manage the subject identification information collectively. FIG. 23 shows a diagram in which subject identification information is collectively managed in a configuration using two caps in a configuration using a plurality of caps. Although the structure which has the apparatus main body 101, the information processing apparatus 301, and the display apparatus 501 with respect to each of two caps is the same as before, the storage device 401 is made into one. It is assumed that all the information stored in the storage device 401 described in the first to sixth embodiments is stored in this one device. According to this configuration, regardless of which cap the subject wears, information such as the subject identification information, the presentation task, and the pigment concentration change can be read out and stored in the same manner as in the above embodiment.

  Next, a sixth embodiment of the biological optical measurement device according to the present invention will be described. In the present embodiment, a situation is assumed in which a TV game using brain function observation data is performed. As an example of the TV game, here is a zazen game, and an example of content displayed on the display device 501 is shown in FIG. The subject wears an easy-wearing cap as shown in FIGS. 16A and 16B and authenticates the subject identification information. After the personal setting is read, the game is started in accordance with the instruction of the display device 501 and the biological information analysis unit 3013 measures biological information such as hemodynamics in the living body at this time. After the game ends, the biological information analysis unit 3013 extracts and analyzes various information (such as a biological activation state) included in the biological information such as hemodynamics. Based on this analysis result, the biological information analysis unit 3013 displays the game result on the display device 501 as shown in FIG. Here, the progress of zazen is displayed, and the previous progress is also displayed to show the change in progress. According to the above configuration, the subject does not need to input subject identification information before starting the game, can start the game simply by wearing the easy-to-wear cap, and whether the progress has been improved compared to the past game results. It will be understood.

Also, if the configuration of the present embodiment is used, if the game is to be finished halfway and continued afterwards, the game and settings that have been halfway finished are stored in the storage device 401, so that the game can be started later. By loading the cap and reading the personal settings, the continuation of the game can be started immediately.

The biological light measurement apparatus according to the present invention includes one or more light irradiating means for irradiating a subject with light, one or more light detecting means for detecting light transmitted or reflected by the subject, and the light detection. Information processing means for calculating the intensity of light detected from the output value of the means and calculating the light attenuation and absorbance in the subject, which is the ratio of the intensity of the detected light to the intensity of light irradiated on the subject And subject information including, as items, the intensity of the irradiated light, the intensity of the detected light, the light attenuation, the absorbance, and the identification information of the subject corresponding to the subject Storage means and display means for displaying the subject information, the intensity of the light irradiated on the subject, the intensity of the light transmitted through or reflected in the subject, and the information processing means Light attenuation And the absorbance are compared with one or a plurality of the subject information stored in advance in the storage means, and the most suitable subject identification information is selected, and the selected identification information is displayed on the previous term display means. I can do it. The living body optical measurement device according to the present invention can not only acquire the biological information of the subject without recognizing the individual subject information, but also can be used as a highly reliable security device as a means for identifying the subject. is there.

1 ... subject,
100 ... the device body,
1000 ... CPU,
1001 ... Electronic circuit,
1002 ... Electronic circuit,
101: Light source element,
102: Light source element,
1011 ... Light irradiation part,
1012: Light irradiation part,
1031 ... Light source driving device,
1032 ... Light source driving device,
1041 ... Gain,
1042 ... Gain,
1051... Analog / digital converter,
1052 ... Analog / digital converter,
201... Light receiving element,
202... Light receiving element,
2011 ... light detection unit,
2012 ... a light detection unit,
301 ... Information processing device,
3011: Authentication unit,
3012 ... assignment presentation section,
3013: Biological information analysis unit,
401... Storage device,
501... Display device,
901 ... Cable,
902 ... Cable,
903 ... cable,
905 ... Optical fiber,
S201: Irradiation light quantity reading step,
S202 ... detected light quantity calculation step,
S203: Light transmittance calculation step,
S204 ... absorbance calculation step,
S205 ... comparing the absorbance with the subject information database;
S206: a step of selecting an optimal subject,
S2061 ... calculating the square average of the difference between the absorbance calculated for each measurement point and the absorbance in the database;
S2062... Selecting the minimum value calculated in S2061;
S2063... Selecting the subject ID selected in S2062;
S2065 ... determining candidate ranks in ascending order of the square average calculated in S2061;
S2066 ... A step of arranging options on the display screen and giving the user choices;
S2067 ... a step of determining whether any of the subject identification information registered in the database does not match,
S2068: determining whether or not the subject is a new subject,
S2069a ... a step for displaying registration as a new subject,
S2069b ... a step of displaying that the subject identification information registered in the database is not applicable,
S207 ... a step of displaying the subject ID of the optimum subject,
S501: irradiation light amount reading step,
S502 ... Detected light quantity calculation step,
S503: Light transmittance calculation step,
S504: a step of setting a specific detected light amount divided by the light transmittance at each measurement point as an irradiation light amount;
S505 ... obtaining absorbance and comparing with subject information database;
S506: selecting an optimal subject,
S507 ... a step of displaying the subject ID of the optimum subject,
S508: reflecting the irradiation light amount and the detected light amount in the database;
S1401 ... calculating a dye density change from a light transmittance change for the problem,
S1402 ... calculating a dye density change obtained from a temporal change in light transmittance stored in the database;
S1403... Calculating the correlation coefficient of the dye density change obtained in S1401 and S1402.
S1404 ... displaying the degree of coincidence based on the correlation coefficient calculated in S1403;
1601 ... Living body light measuring device,
1701 ... Living body light measurement device,
17011 ... A part of the biological light measuring device 1701

Claims (6)

One or more light irradiation means for irradiating the subject with light;
One or more light detection means for detecting light transmitted or reflected inside the subject;
The intensity of the detected light is calculated from the output value of the light detection means, and the light attenuation and absorbance in the subject, which are the ratio of the intensity of the detected light to the intensity of the light irradiated on the subject, are calculated. Information processing means;
Storage means,
The intensity of light irradiated on the subject, the intensity of light transmitted or reflected inside the subject, and the light attenuation and absorbance calculated by the information processing means are stored in the storage means in advance or A biological light measurement apparatus characterized by comparing with a plurality of object information and displaying the comparison result on the display means. The biological light measurement device according to claim 1,
The storage means corresponds to the subject, and includes a subject whose items are the intensity of the irradiated light, the intensity of the detected light, the light attenuation, the absorbance, and the identification information of the subject. A biological light measurement device, characterized in that it is stored as information. The biological light measurement device according to claim 1,
The information processing means selects identification information of a subject based on the comparison result,
The biological light measuring device, wherein the selected identification information is displayed on the display means. The biological light measurement device according to claim 1,
The information processing means measures a temporal change in the light attenuation amount, and stores the temporal change in the light attenuation amount as a new item in the subject information in the storage means, Biological light measurement device. The biological light measurement device according to claim 4,
There are a plurality of wavelengths of light to be applied to the subject, and the storage means stores in advance an absorption spectrum of one or more pigment substances contained in the subject,
The information processing means presents a specific problem to the subject by the display device, changes with time of the light attenuation amount for each wavelength, and one or a plurality of the dyes stored in the storage means Based on the absorption spectrum of the substance, the temporal change in the concentration of the dye substance is calculated, and the subject information in the storage means includes the content of the problem and the concentration of the dye substance corresponding to the problem over time. Biological light measurement device characterized by storing various changes as new items.   The biological light measurement apparatus according to claim 1, wherein the intensity of light applied to the subject is adjusted so that the intensity of light detected by one or more of the light detection means is constant. A living body light measurement device.