JP2010540654A - ゲルからのコンプスタチンアナログの持続的送達 - Google Patents

ゲルからのコンプスタチンアナログの持続的送達 Download PDF

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Publication number
JP2010540654A
JP2010540654A JP2010528129A JP2010528129A JP2010540654A JP 2010540654 A JP2010540654 A JP 2010540654A JP 2010528129 A JP2010528129 A JP 2010528129A JP 2010528129 A JP2010528129 A JP 2010528129A JP 2010540654 A JP2010540654 A JP 2010540654A
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Prior art keywords
compstatin analog
liquid composition
compstatin
composition
analog
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JP2010528129A
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Japanese (ja)
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JP2010540654A5 (https=
Inventor
セドリック フランソワ，
パスカル デスシャテレツ，
ポール オルソン，
Original Assignee
ポテンシア ファーマシューティカルズ， インコーポレイテッド
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Publication of JP2010540654A publication Critical patent/JP2010540654A/ja
Publication of JP2010540654A5 publication Critical patent/JP2010540654A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nanotechnology (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2010528129A 2007-10-02 2008-10-02 ゲルからのコンプスタチンアナログの持続的送達 Pending JP2010540654A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97691907P 2007-10-02 2007-10-02
US2646008P 2008-02-05 2008-02-05
PCT/US2008/078593 WO2009046198A2 (en) 2007-10-02 2008-10-02 Sustained delivery of compstatin analogs from gels

Publications (2)

Publication Number Publication Date
JP2010540654A true JP2010540654A (ja) 2010-12-24
JP2010540654A5 JP2010540654A5 (https=) 2011-10-27

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ID=40526950

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010528129A Pending JP2010540654A (ja) 2007-10-02 2008-10-02 ゲルからのコンプスタチンアナログの持続的送達

Country Status (12)

Country Link
US (1) US20110182877A1 (https=)
EP (1) EP2207530A4 (https=)
JP (1) JP2010540654A (https=)
KR (2) KR20150080007A (https=)
CN (1) CN101854916A (https=)
AU (1) AU2008308657A1 (https=)
BR (1) BRPI0817524A2 (https=)
CA (1) CA2701470A1 (https=)
MX (1) MX2010003630A (https=)
RU (1) RU2505311C2 (https=)
WO (1) WO2009046198A2 (https=)
ZA (1) ZA201002365B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014523882A (ja) * 2011-06-22 2014-09-18 アペリス・ファーマシューティカルズ・インコーポレイテッド 補体阻害剤による慢性障害の治療方法
JP2024028797A (ja) * 2017-12-15 2024-03-05 アペリス・ファーマシューティカルズ・インコーポレイテッド 投与レジメンならびに関連組成物および方法
US12528836B2 (en) 2015-10-07 2026-01-20 Apellis Pharmaceuticals, Inc. Dosing regimens

Families Citing this family (24)

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US8168584B2 (en) * 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
WO2009015087A2 (en) * 2007-07-20 2009-01-29 Potentia Pharmaceuticals, Inc. Compositions and methods for treatment of trauma
US20110190221A1 (en) * 2008-03-28 2011-08-04 Apellis Ag Modulation and repletion/enhancement of the complement system for treatment of trauma
TWI492769B (zh) * 2009-09-23 2015-07-21 Alcon Res Ltd 可注射的水性眼用組成物及其使用之方法
WO2011163394A2 (en) 2010-06-22 2011-12-29 Apellis Pharmaceuticals, Inc. Compstatin analogs for treatment of neuropathic pain
JP5829685B2 (ja) 2010-09-03 2015-12-09 サンテン・エス・エー・エス 眼の疾患を処置するための油中水型エマルション
US9107822B2 (en) 2010-09-03 2015-08-18 Santen Sas Water-in oil type emulsion for treating a disease of the eye
PT2425814E (pt) 2010-09-03 2013-09-02 Novagali Pharma Sa Emulsão de tipo água em óleo para tratamento de uma doença ocular
MX356528B (es) 2011-05-11 2018-06-01 Apellis Pharmaceuticals Inc Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y usos de los mismos.
WO2014028861A1 (en) * 2012-08-17 2014-02-20 Apellis Pharmaceuticals, Inc. Detection of high risk drusen
MX366404B (es) 2012-11-15 2019-07-08 Apellis Pharmaceuticals Inc Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y composiciones y metodos relacionados.
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
US9940683B2 (en) 2013-07-31 2018-04-10 Elwha Llc Managing a risk of a liability that is incurred if a subject treated for a condition is retreated within a specified time period
US20150039337A1 (en) * 2013-07-31 2015-02-05 Elwha Llc Managing a risk of a liability that is incurred if one or more subjects each treated for a respective condition are retreated within a respective specified time period
EP2918262B1 (en) 2014-03-10 2023-08-09 PLS-Design GmbH Induction of antigen-specific tolerance by peripheral phagocytosis
EP3973994A1 (en) 2014-06-12 2022-03-30 RA Pharmaceuticals, Inc. Modulation of complement activity
US20180228811A1 (en) * 2014-12-12 2018-08-16 The Schepens Eye Research Institute, Inc. Gdnf induction for the treatment of retinal disorders
US9937222B2 (en) 2015-01-28 2018-04-10 Ra Pharmaceuticals, Inc. Modulators of complement activity
EP3095440B1 (en) 2015-05-19 2020-01-15 PLS-Design GmbH Antigen-specific immunotherapy using tolerizing liposomes
RU2733720C2 (ru) 2015-12-16 2020-10-06 Ра Фармасьютикалз, Инк. Модуляторы активности комплемента
KR20190093196A (ko) 2016-12-07 2019-08-08 라 파마슈티컬스 인코포레이티드 보체 활성의 조절인자
RU2661621C2 (ru) * 2016-12-19 2018-07-17 Александр Николаевич Епихин Способ пролонгации и усиления терапевтического эффекта действия ингибиторов ангиогенеза при лечении неоваскулярных форм макулярных дегенераций
IL269844B2 (en) 2017-04-07 2025-01-01 Apellis Pharmaceuticals Inc Dosage regimens and related compositions and methods
JP2022535411A (ja) 2019-06-04 2022-08-08 ラ ファーマシューティカルズ インコーポレイテッド 補体阻害剤による炎症性疾患治療

Citations (1)

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WO2007044668A2 (en) * 2005-10-08 2007-04-19 Potentia Pharmaceuticals, Inc. Compstatin and analogs thereof for eye disorders

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US7488590B2 (en) * 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
PT1549333E (pt) * 2002-09-20 2012-01-03 Univ Pennsylvania Análogos de compstatina com actividade melhorada
US8168584B2 (en) * 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
CN102977191B (zh) * 2005-11-28 2016-08-10 宾夕法尼亚州大学理事会 有效的c3补体抑制素类似物
KR20080087814A (ko) * 2005-12-22 2008-10-01 알콘 리서치, 리미티드 보체 인자 ｈ의 위험 변이체가 있는 환자에서 연령 관련황반변성의 예방 및 치료를 위한 ｃ3-전환효소 저해제
US20070196367A1 (en) * 2006-02-22 2007-08-23 Valentin Dinu Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system
HUE026001T2 (en) * 2007-02-05 2016-04-28 Apellis Pharmaceuticals Inc Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system

Patent Citations (1)

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WO2007044668A2 (en) * 2005-10-08 2007-04-19 Potentia Pharmaceuticals, Inc. Compstatin and analogs thereof for eye disorders

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014523882A (ja) * 2011-06-22 2014-09-18 アペリス・ファーマシューティカルズ・インコーポレイテッド 補体阻害剤による慢性障害の治療方法
US10039802B2 (en) 2011-06-22 2018-08-07 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
JP2018138603A (ja) * 2011-06-22 2018-09-06 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 補体阻害剤による慢性障害の治療方法
JP2020045361A (ja) * 2011-06-22 2020-03-26 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 補体阻害剤による慢性障害の治療方法
US11013782B2 (en) 2011-06-22 2021-05-25 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
US11712460B2 (en) 2011-06-22 2023-08-01 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
US12528836B2 (en) 2015-10-07 2026-01-20 Apellis Pharmaceuticals, Inc. Dosing regimens
JP2024028797A (ja) * 2017-12-15 2024-03-05 アペリス・ファーマシューティカルズ・インコーポレイテッド 投与レジメンならびに関連組成物および方法
US12290566B2 (en) 2017-12-15 2025-05-06 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
US12458695B2 (en) 2017-12-15 2025-11-04 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods

Also Published As

Publication number Publication date
CN101854916A (zh) 2010-10-06
RU2505311C2 (ru) 2014-01-27
KR20150080007A (ko) 2015-07-08
CA2701470A1 (en) 2009-04-09
EP2207530A2 (en) 2010-07-21
KR20100094453A (ko) 2010-08-26
US20110182877A1 (en) 2011-07-28
RU2010113513A (ru) 2011-11-10
AU2008308657A1 (en) 2009-04-09
EP2207530A4 (en) 2013-09-11
ZA201002365B (en) 2010-12-29
WO2009046198A3 (en) 2009-07-16
MX2010003630A (es) 2010-04-21
BRPI0817524A2 (pt) 2017-05-02
WO2009046198A2 (en) 2009-04-09

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