JP2010537958A - Ｆａｂｐ４／ａｐ２を調節するためのｒｎａアンタゴニスト化合物 - Google Patents

Ｆａｂｐ４／ａｐ２を調節するためのｒｎａアンタゴニスト化合物 Download PDF

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JP2010537958A
JP2010537958A JP2010522397A JP2010522397A JP2010537958A JP 2010537958 A JP2010537958 A JP 2010537958A JP 2010522397 A JP2010522397 A JP 2010522397A JP 2010522397 A JP2010522397 A JP 2010522397A JP 2010537958 A JP2010537958 A JP 2010537958A
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oligomer
fabp4
lna
nucleotide
nucleobase
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JP2010537958A5 (enExample
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キース・マクラフ
エレン・マリー・ストラルプ
ニールス・フィスカー・ニールセン
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Roche Innovation Center Copenhagen AS
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Santaris Pharma AS
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===

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JP2010522397A 2007-08-30 2008-08-29 Ｆａｂｐ４／ａｐ２を調節するためのｒｎａアンタゴニスト化合物 Withdrawn JP2010537958A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96901607P 2007-08-30 2007-08-30
PCT/EP2008/061432 WO2009027527A2 (en) 2007-08-30 2008-08-29 Rna antagonist compounds for the modulation of fabp4/ap2

Publications (2)

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JP2010537958A true JP2010537958A (ja) 2010-12-09
JP2010537958A5 JP2010537958A5 (enExample) 2011-10-13

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JP2010522397A Withdrawn JP2010537958A (ja) 2007-08-30 2008-08-29 Ｆａｂｐ４／ａｐ２を調節するためのｒｎａアンタゴニスト化合物

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US (1) US20110054011A1 (enExample)
EP (1) EP2198024A2 (enExample)
JP (1) JP2010537958A (enExample)
AU (1) AU2008292091A1 (enExample)
CA (1) CA2697970A1 (enExample)
WO (1) WO2009027527A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016526529A (ja) * 2013-06-16 2016-09-05 国立大学法人 東京医科歯科大学 エクソンスキッピング効果を有する二本鎖アンチセンス核酸

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011009751A (es) * 2009-03-16 2011-09-29 Opko Curna Llc Tratamiento de enfermedades relacionadas con factor nuclear (eritroide derivado 2) tipo 2 (nrf2) por inhibicion del transcrito antisentido natural a nrf2.
CA2769665A1 (en) * 2009-08-05 2011-02-10 Opko Curna, Llc Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
WO2015009544A1 (en) * 2013-07-11 2015-01-22 Texas Heart Institute Rna interference of fabp4 for the treatment of atherosclerosis

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US4962029A (en) * 1987-10-02 1990-10-09 Cetus Corporation Covalent oligonucleotide-horseradish peroxidase conjugate
US4914210A (en) * 1987-10-02 1990-04-03 Cetus Corporation Oligonucleotide functionalizing reagents
US6423489B1 (en) * 1992-09-10 2002-07-23 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus-associated diseases
ATE202383T1 (de) * 1992-09-10 2001-07-15 Isis Pharmaceuticals Inc Zusammensetzungen und verfahren für die behandlung von mit hepatitis c viren assoziierten krankheiten
US6433159B1 (en) * 1992-09-10 2002-08-13 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus associated diseases
US5919795A (en) * 1995-06-07 1999-07-06 Pfizer Inc. Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion
TR199901180T2 (xx) * 1996-11-27 1999-08-23 Pfizer Inc. Apo B-Salg�lama/MTP inhibit�r amidler.
JP2001514508A (ja) * 1997-03-05 2001-09-11 ユニバーシティー オブ ワシントン Ｃ型肝炎ウイルスの複製を選択的に抑制する薬剤を同定するための新規なスクリーニング法
AU2003261434A1 (en) * 2002-08-12 2004-02-25 Bristol-Myers Squibb Company Iminothiazolidinones as inhibitors of hcv replication
UA79300C2 (en) * 2002-08-12 2007-06-11 Janssen Pharmaceutica Nv N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion
US7087229B2 (en) * 2003-05-30 2006-08-08 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
FR2848572B1 (fr) * 2002-12-12 2005-12-09 Univ Joseph Fourier Molecules inhibitrices de la synthese proteique du virus de l'hepatite c et procede de criblage desdites molecules inhibitrices
DE10300861A1 (de) * 2003-01-10 2004-07-22 Metagen Pharmaceuticals Gmbh Verwendung von an FABP4 bindenden Substanzen zur Diagnose und Behandlung des Harnblasenkarzinoms
WO2004076614A2 (de) * 2003-02-27 2004-09-10 Bernd Hinzmann Humane nukleinsäuresequenzen aus prostatakarzinomen
WO2005013901A2 (en) * 2003-07-31 2005-02-17 Isis Pharmaceuticals, Inc. Oligomeric compounds and compositions for use in modulation of small non-coding rnas
SI2409713T1 (sl) * 2004-08-10 2015-10-30 Genzyme Corporation Oligonukleotidi za uporabo pri uravnavanju nivojev lipoproteinov in holesterola pri ljudeh
EP2076597A2 (en) * 2006-10-09 2009-07-08 Santaris Pharma A/S Rna antagonist compounds for the modulation of pcsk9

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016526529A (ja) * 2013-06-16 2016-09-05 国立大学法人 東京医科歯科大学 エクソンスキッピング効果を有する二本鎖アンチセンス核酸
US10190117B2 (en) 2013-06-16 2019-01-29 National University Corporation Tokyo Medical And Dental University Double-stranded antisense nucleic acid with exon-skipping effect

Also Published As

Publication number Publication date
WO2009027527A3 (en) 2009-07-02
CA2697970A1 (en) 2009-03-05
WO2009027527A2 (en) 2009-03-05
EP2198024A2 (en) 2010-06-23
AU2008292091A1 (en) 2009-03-05
US20110054011A1 (en) 2011-03-03

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