JP2010535811A - 薬物キャリアとしてのクロロトキシン - Google Patents

薬物キャリアとしてのクロロトキシン Download PDF

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Publication number
JP2010535811A
JP2010535811A JP2010520313A JP2010520313A JP2010535811A JP 2010535811 A JP2010535811 A JP 2010535811A JP 2010520313 A JP2010520313 A JP 2010520313A JP 2010520313 A JP2010520313 A JP 2010520313A JP 2010535811 A JP2010535811 A JP 2010535811A
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JP
Japan
Prior art keywords
cancer
conjugate
moiety
agent
toxin
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JP2010520313A
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English (en)
Japanese (ja)
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JP2010535811A5 (https=
Inventor
ダグラス ヤコビー,
アブデラー センティッシ,
Original Assignee
トランスモレキュラー, インコーポレイテッド
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Application filed by トランスモレキュラー, インコーポレイテッド filed Critical トランスモレキュラー, インコーポレイテッド
Publication of JP2010535811A publication Critical patent/JP2010535811A/ja
Publication of JP2010535811A5 publication Critical patent/JP2010535811A5/ja
Withdrawn legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2010520313A 2007-08-07 2008-08-07 薬物キャリアとしてのクロロトキシン Withdrawn JP2010535811A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95440907P 2007-08-07 2007-08-07
PCT/US2008/072524 WO2009021136A1 (en) 2007-08-07 2008-08-07 Chlorotoxins as drug carriers

Publications (2)

Publication Number Publication Date
JP2010535811A true JP2010535811A (ja) 2010-11-25
JP2010535811A5 JP2010535811A5 (https=) 2011-09-22

Family

ID=40341745

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010520313A Withdrawn JP2010535811A (ja) 2007-08-07 2008-08-07 薬物キャリアとしてのクロロトキシン

Country Status (6)

Country Link
US (1) US20110091380A1 (https=)
EP (1) EP2173385A1 (https=)
JP (1) JP2010535811A (https=)
AU (1) AU2008285364A1 (https=)
CA (1) CA2696303A1 (https=)
WO (1) WO2009021136A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006020710D1 (de) * 2005-04-22 2011-04-28 Fred Hutchinson Cancer Res Foundation Fluoreszentes chlorotoxinkonjugat und verfahren zur intraoperativen sichtbarmachung von krebs
CA2724384A1 (en) 2008-05-15 2009-11-19 Transmolecular, Inc. Treatment of metastatic tumors
CN102844044B (zh) 2010-02-04 2016-10-26 摩尔弗泰克有限公司 氯毒素多肽和结合物及其应用
WO2011126010A1 (ja) * 2010-04-06 2011-10-13 三菱化学株式会社 癌細胞選択的膜透過性ペプチドおよびその利用
EP3165533B1 (en) 2010-05-11 2020-04-08 Fred Hutchinson Cancer Research Center Chlorotoxin variants, conjugates and methods for their use
WO2013003507A1 (en) 2011-06-27 2013-01-03 Morphotek, Inc. Multifunctional agents
CA2913029A1 (en) 2012-12-10 2014-06-19 Fred Hutchinson Cancer Research Center Lipocalin fusion partners
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
US12048732B2 (en) 2016-04-15 2024-07-30 Blaze Bioscience, Inc. Methods of treating breast cancer
US11421005B2 (en) * 2016-12-09 2022-08-23 The Uab Research Foundation Chimeric chlorotoxin receptors
CN111542345B (zh) 2017-09-15 2025-02-25 卫材公司 氯毒素剂及其用途
CA3086040A1 (en) 2017-12-19 2019-06-27 Blaze Bioscience, Inc. Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5905027A (en) * 1995-12-27 1999-05-18 Uab Research Foundation Method of diagnosing and treating gliomas
US6667156B2 (en) * 1995-12-27 2003-12-23 Uab Research Foundation Diagnosis and treatment of neuroectodermal tumors
AU2003237347B2 (en) * 2002-05-31 2009-07-23 Transmolecular Inc. Treatment of cell proliferative disorders with chlorotoxin
US20060088899A1 (en) * 2002-05-31 2006-04-27 Alvarez Vernon L Combination chemotherapy with chlorotoxin
WO2006091231A2 (en) * 2004-07-21 2006-08-31 Ambrx, Inc. Biosynthetic polypeptides utilizing non-naturally encoded amino acids
DE602006020710D1 (de) * 2005-04-22 2011-04-28 Fred Hutchinson Cancer Res Foundation Fluoreszentes chlorotoxinkonjugat und verfahren zur intraoperativen sichtbarmachung von krebs

Also Published As

Publication number Publication date
WO2009021136A1 (en) 2009-02-12
US20110091380A1 (en) 2011-04-21
CA2696303A1 (en) 2009-02-12
EP2173385A1 (en) 2010-04-14
AU2008285364A1 (en) 2009-02-12

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