JP2010533478A5 - - Google Patents
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- Publication number
- JP2010533478A5 JP2010533478A5 JP2010516305A JP2010516305A JP2010533478A5 JP 2010533478 A5 JP2010533478 A5 JP 2010533478A5 JP 2010516305 A JP2010516305 A JP 2010516305A JP 2010516305 A JP2010516305 A JP 2010516305A JP 2010533478 A5 JP2010533478 A5 JP 2010533478A5
- Authority
- JP
- Japan
- Prior art keywords
- gamma secretase
- seq
- ledaefrhds
- lvml
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 51
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 51
- 239000000758 substrate Substances 0.000 claims 37
- 238000000034 method Methods 0.000 claims 30
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 11
- 230000000694 effects Effects 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 238000003776 cleavage reaction Methods 0.000 claims 8
- 230000007017 scission Effects 0.000 claims 8
- 229910052698 phosphorus Inorganic materials 0.000 claims 6
- 229910052700 potassium Inorganic materials 0.000 claims 6
- 231100000673 dose–response relationship Toxicity 0.000 claims 5
- 102100040038 Amyloid beta precursor like protein 2 Human genes 0.000 claims 4
- 102100032912 CD44 antigen Human genes 0.000 claims 4
- 101000890401 Homo sapiens Amyloid beta precursor like protein 2 Proteins 0.000 claims 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 102000003425 Tyrosinase Human genes 0.000 claims 4
- 108060008724 Tyrosinase Proteins 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 4
- 101800001415 Bri23 peptide Proteins 0.000 claims 2
- 102400000107 C-terminal peptide Human genes 0.000 claims 2
- 101800000655 C-terminal peptide Proteins 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 102220349549 c.73G>A Human genes 0.000 claims 2
- 229910052805 deuterium Inorganic materials 0.000 claims 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 102200097281 rs35807406 Human genes 0.000 claims 2
- 102200153449 rs587777876 Human genes 0.000 claims 2
- 229910052722 tritium Inorganic materials 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94973807P | 2007-07-13 | 2007-07-13 | |
| PCT/US2008/070012 WO2009012237A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase |
| US12/172,978 US20090023158A1 (en) | 2007-07-13 | 2008-07-14 | Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010533478A JP2010533478A (ja) | 2010-10-28 |
| JP2010533478A5 true JP2010533478A5 (OSRAM) | 2011-09-01 |
Family
ID=39739883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010516305A Withdrawn JP2010533478A (ja) | 2007-07-13 | 2008-07-14 | ガンマセクレターゼの阻害剤の基質特異性を同定するための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20090023158A1 (OSRAM) |
| EP (1) | EP2183598A1 (OSRAM) |
| JP (1) | JP2010533478A (OSRAM) |
| CA (1) | CA2692604A1 (OSRAM) |
| WO (1) | WO2009012237A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5511377B2 (ja) * | 2007-06-08 | 2014-06-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ＥｐｈＡ４を利用したスクリーニング方法 |
| JPWO2009011426A1 (ja) * | 2007-07-19 | 2010-09-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | γ−セクレターゼの新規基質ｃ−Ｍｅｔを利用したスクリーニング方法 |
| US20100190184A1 (en) * | 2007-08-01 | 2010-07-29 | Eisai R & D Management Co., Ltd. | Screening method utilizing novel substrate c-ret for gamma-secretase |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
| US8530181B2 (en) * | 2007-11-15 | 2013-09-10 | Eisai R&D Management Co., Ltd. | Method of screening for compounds which affect the cleavage of EphA7 byγ-secretase |
| DK2223999T3 (en) * | 2007-11-30 | 2017-12-18 | Eisai R&D Man Co Ltd | EPHA4 POLYPEPTIDE WITH UNKNOWN ACTIVITY AND USE THEREOF |
| EP2653552B1 (en) | 2010-12-17 | 2016-10-19 | Eisai R&D Management Co., Ltd. | SCREENING METHOD USING GELATINASE-MEDIATED EphA4 CLEAVAGE REACTION AS AN INDICATOR |
| US9784751B2 (en) | 2011-04-25 | 2017-10-10 | Eisai R&D Management Co., Ltd. | Method for detecting neurological disease associated with cognitive impairment by measuring EphA4 extracellular domain |
| RU2627177C2 (ru) | 2012-06-22 | 2017-08-03 | Джентиум С.Р.Л. | Способ определения биологической активности дефибротида, основанный на применении эуглобулина |
| EP3026122A1 (en) * | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| WO2019169243A1 (en) * | 2018-03-02 | 2019-09-06 | Ionis Pharmaceuticals, Inc. | Compounds and methods for the modulation of amyloid-beta precursor protein |
| CN117398459A (zh) | 2019-07-01 | 2024-01-16 | 卫材R&D管理有限公司 | 抗EphA4抗体 |
| WO2021174075A1 (en) * | 2020-02-27 | 2021-09-02 | Adeptrix Corp. | Multiplexed bead-based analytical assays |
| US20230174612A1 (en) * | 2020-04-09 | 2023-06-08 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| UY39344A (es) | 2020-07-28 | 2022-02-25 | Ionis Pharmaceuticals Inc | Compuestos y métodos para reducir la expresión de app |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| US5441870A (en) * | 1992-04-15 | 1995-08-15 | Athena Neurosciences, Inc. | Methods for monitoring cellular processing of β-amyloid precursor protein |
| US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US5605811A (en) | 1992-10-26 | 1997-02-25 | Athena Neurosciences, Inc. | Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein |
| ES2155099T3 (es) | 1993-10-27 | 2001-05-01 | Elan Pharm Inc | Animales transgenicos que albergan alelos app que presentan una mutacion sueca. |
| DE10131899A1 (de) * | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| WO2007058987A1 (en) * | 2005-11-10 | 2007-05-24 | Bristol-Myers Squibb Company | Methods of identifying compounds that inhibit notch cleavage |
| US20090163594A1 (en) * | 2007-10-31 | 2009-06-25 | Elan Pharmaceuticals, Inc. | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors |
-
2008
- 2008-07-14 JP JP2010516305A patent/JP2010533478A/ja not_active Withdrawn
- 2008-07-14 EP EP08826401A patent/EP2183598A1/en not_active Withdrawn
- 2008-07-14 CA CA 2692604 patent/CA2692604A1/en not_active Abandoned
- 2008-07-14 US US12/172,978 patent/US20090023158A1/en not_active Abandoned
- 2008-07-14 WO PCT/US2008/070012 patent/WO2009012237A1/en not_active Ceased
-
2011
- 2011-03-08 US US13/043,278 patent/US20110306071A1/en not_active Abandoned
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