JP2010523620A5 - - Google Patents
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- Publication number
- JP2010523620A5 JP2010523620A5 JP2010502504A JP2010502504A JP2010523620A5 JP 2010523620 A5 JP2010523620 A5 JP 2010523620A5 JP 2010502504 A JP2010502504 A JP 2010502504A JP 2010502504 A JP2010502504 A JP 2010502504A JP 2010523620 A5 JP2010523620 A5 JP 2010523620A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- enantiomeric excess
- weight
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 7
- 239000003638 chemical reducing agent Substances 0.000 claims 4
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 claims 4
- 229960001785 mirtazapine Drugs 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000006227 byproduct Substances 0.000 claims 3
- 150000002576 ketones Chemical class 0.000 claims 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 3
- -1 carboxylic acid compound Chemical class 0.000 claims 2
- 125000002843 carboxylic acid group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000004678 hydrides Chemical class 0.000 claims 2
- 150000002440 hydroxy compounds Chemical class 0.000 claims 2
- 229910052987 metal hydride Inorganic materials 0.000 claims 2
- 150000004681 metal hydrides Chemical class 0.000 claims 2
- 239000002841 Lewis acid Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012320 chlorinating reagent Substances 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 150000007517 lewis acids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910001507 metal halide Inorganic materials 0.000 claims 1
- 150000005309 metal halides Chemical class 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 238000011946 reduction process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07105985.1 | 2007-04-11 | ||
| EP07105985 | 2007-04-11 | ||
| PCT/EP2008/054316 WO2008125578A2 (en) | 2007-04-11 | 2008-04-10 | A method for the preparation of mirtazapine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523620A JP2010523620A (ja) | 2010-07-15 |
| JP2010523620A5 true JP2010523620A5 (OSRAM) | 2011-05-26 |
| JP5635905B2 JP5635905B2 (ja) | 2014-12-03 |
Family
ID=38474342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502504A Active JP5635905B2 (ja) | 2007-04-11 | 2008-04-10 | ミルタザピンの調製方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2146993B1 (OSRAM) |
| JP (1) | JP5635905B2 (OSRAM) |
| CN (1) | CN101679431B (OSRAM) |
| AR (1) | AR066005A1 (OSRAM) |
| CA (1) | CA2684021A1 (OSRAM) |
| MX (1) | MX2009010967A (OSRAM) |
| WO (1) | WO2008125578A2 (OSRAM) |
| ZA (1) | ZA200907537B (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140004114A (ko) * | 2011-03-31 | 2014-01-10 | 가부시키가이샤 가네카 | 환상 아민 화합물의 제조법 |
| WO2016138357A1 (en) | 2015-02-27 | 2016-09-01 | Kindred Biosciences, Inc. | Stimulation of appetite, management of weight loss, and treatment of anorexia in dogs and cats |
| CN121204204A (zh) * | 2025-11-27 | 2025-12-26 | 山东静远药业有限公司 | 一种苯磺酸米洛巴林关键中间体的对映体杂质的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| US6303595B1 (en) | 1997-11-14 | 2001-10-16 | Akzo Nobel N.V. | Use of mirtazapine for treating sleep apneas |
| KR20020019902A (ko) | 1999-04-19 | 2002-03-13 | 추후보정 | 피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법 |
| AU6476300A (en) | 1999-09-30 | 2001-05-10 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a piperazine derivative |
| AU6474200A (en) | 1999-12-13 | 2001-06-18 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
| EP1658850A1 (en) | 2000-02-11 | 2006-05-24 | Akzo Nobel N.V. | The use of mirtazapine for the treatment of sleep disorders |
| EP1426356B1 (en) | 2001-09-14 | 2008-04-16 | Medichem S.A. | Intermediate compounds for the preparation of mirtazapine and the production methods thereof |
| US6806283B2 (en) * | 2002-05-06 | 2004-10-19 | Virginia Commonwealth University | Selective serotonin receptor antagonists and therapeutic applications thereof |
| UA83666C2 (ru) * | 2003-07-10 | 2008-08-11 | Н.В. Органон | Способ получения энантиомерно чистого миртазапина |
| EA015104B1 (ru) * | 2003-08-01 | 2011-06-30 | Мицубиси Танабе Фарма Корпорейшн | Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортера |
| JP2007284358A (ja) | 2006-04-13 | 2007-11-01 | Sumitomo Chemical Co Ltd | 光学活性なピペラジン化合物の製造方法 |
| TW200815370A (en) * | 2006-06-16 | 2008-04-01 | Organon Nv | Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine |
-
2008
- 2008-04-10 JP JP2010502504A patent/JP5635905B2/ja active Active
- 2008-04-10 EP EP08736038.4A patent/EP2146993B1/en active Active
- 2008-04-10 WO PCT/EP2008/054316 patent/WO2008125578A2/en not_active Ceased
- 2008-04-10 CN CN200880016144.9A patent/CN101679431B/zh active Active
- 2008-04-10 MX MX2009010967A patent/MX2009010967A/es not_active Application Discontinuation
- 2008-04-10 AR ARP080101475 patent/AR066005A1/es unknown
- 2008-04-10 CA CA002684021A patent/CA2684021A1/en not_active Abandoned
-
2009
- 2009-10-27 ZA ZA200907537A patent/ZA200907537B/xx unknown