JP2010520855A - 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー - Google Patents

修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー Download PDF

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Publication number
JP2010520855A
JP2010520855A JP2009548419A JP2009548419A JP2010520855A JP 2010520855 A JP2010520855 A JP 2010520855A JP 2009548419 A JP2009548419 A JP 2009548419A JP 2009548419 A JP2009548419 A JP 2009548419A JP 2010520855 A JP2010520855 A JP 2010520855A
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JP
Japan
Prior art keywords
integer
moiety
peptide
compound
linker
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Pending
Application number
JP2009548419A
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English (en)
Japanese (ja)
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JP2010520855A5 (enExample
Inventor
ホームズ，クリストファー，ピー．
チャクラバーティ，アンジャン
フレデリック，ブライアン，ティー．
パン，イージュン
ドン，ヤオファー，エス．
アショーカ，バンダリ
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Affymax Inc
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Affymax Inc
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Application filed by Affymax Inc filed Critical Affymax Inc
Publication of JP2010520855A publication Critical patent/JP2010520855A/ja
Publication of JP2010520855A5 publication Critical patent/JP2010520855A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
JP2009548419A 2007-01-31 2008-01-30 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー Pending JP2010520855A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89886807P 2007-01-31 2007-01-31
PCT/US2008/052467 WO2008095004A2 (en) 2007-01-31 2008-01-30 Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013198572A Division JP2014051498A (ja) 2007-01-31 2013-09-25 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー

Publications (2)

Publication Number Publication Date
JP2010520855A true JP2010520855A (ja) 2010-06-17
JP2010520855A5 JP2010520855A5 (enExample) 2011-03-17

Family

ID=39674769

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009548419A Pending JP2010520855A (ja) 2007-01-31 2008-01-30 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー
JP2013198572A Pending JP2014051498A (ja) 2007-01-31 2013-09-25 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013198572A Pending JP2014051498A (ja) 2007-01-31 2013-09-25 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー

Country Status (5)

Country Link
US (2) US8106154B2 (enExample)
EP (1) EP2118127A4 (enExample)
JP (2) JP2010520855A (enExample)
CA (1) CA2676820A1 (enExample)
WO (1) WO2008095004A2 (enExample)

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US8101729B2 (en) * 2007-03-19 2012-01-24 Henry Joseph Niemczyk Pegylated amino acid derivatives and the process to synthesize the same
KR101200659B1 (ko) 2008-07-23 2012-11-12 한미사이언스 주식회사 세 말단 반응기를 갖는 비펩타이드성 중합체를 이용한 생리활성 폴리펩타이드 약물 결합체
CN102939302A (zh) * 2010-03-24 2013-02-20 医药研究委员会 方法
EP2709648A4 (en) * 2011-05-19 2015-04-08 Geysen Hendrik M COMPOUNDS FOR BINDING TO THE ERYTHROPOIETIN RECEPTOR
EP2592103A1 (en) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymer aldehyde derivatives
EP2958947B1 (en) * 2013-02-20 2019-08-14 The University of Queensland Conjugate compound and uses of same
WO2015031536A1 (en) 2013-08-27 2015-03-05 Northeastern University Nanoparticle drug delivery system and method of treating cancer and neurotrauma
WO2016025752A1 (en) * 2014-08-14 2016-02-18 Prolynx Llc Reagents for thiol conjugation and conjugates formed therefrom
KR101811996B1 (ko) * 2015-06-09 2018-01-30 경희대학교 산학협력단 신규 페길화 서브스턴스 ｐ
US10526284B2 (en) * 2016-12-21 2020-01-07 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery
KR102142978B1 (ko) * 2017-12-18 2020-08-11 경희대학교 산학협력단 신규 페길화 서브스턴스 ｐ

Citations (5)

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WO2004101606A2 (en) * 2003-05-12 2004-11-25 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
JP2006505634A (ja) * 2002-08-13 2006-02-16 エンゾン，インコーポレーテッド 脂肪族生物分解性リンカーに基づく放出可能な高分子コンジュゲート
WO2006060148A2 (en) * 2004-11-11 2006-06-08 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
WO2006062685A2 (en) * 2004-11-11 2006-06-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
WO2006133144A2 (en) * 2005-06-03 2006-12-14 Affymax, Inc. Erythropoietin receptor peptide formulations and uses

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Also Published As

Publication number Publication date
US20090048147A1 (en) 2009-02-19
US8106154B2 (en) 2012-01-31
WO2008095004A3 (en) 2010-03-25
WO2008095004A2 (en) 2008-08-07
EP2118127A2 (en) 2009-11-18
CA2676820A1 (en) 2008-08-07
EP2118127A4 (en) 2010-12-01
JP2014051498A (ja) 2014-03-20
US20120165275A1 (en) 2012-06-28

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