JP2010517991A5 - - Google Patents
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- Publication number
- JP2010517991A5 JP2010517991A5 JP2009547779A JP2009547779A JP2010517991A5 JP 2010517991 A5 JP2010517991 A5 JP 2010517991A5 JP 2009547779 A JP2009547779 A JP 2009547779A JP 2009547779 A JP2009547779 A JP 2009547779A JP 2010517991 A5 JP2010517991 A5 JP 2010517991A5
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- JP
- Japan
- Prior art keywords
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- composition
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 2
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- -1 2-methylpyridin-3-yl Chemical group 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88798107P | 2007-02-02 | 2007-02-02 | |
| PCT/IB2008/000249 WO2008093236A1 (en) | 2007-02-02 | 2008-01-28 | Tricyclic compounds and their use as glucocorticoid receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010517991A JP2010517991A (ja) | 2010-05-27 |
| JP2010517991A5 true JP2010517991A5 (cg-RX-API-DMAC7.html) | 2010-09-24 |
| JP4579333B2 JP4579333B2 (ja) | 2010-11-10 |
Family
ID=39887754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547779A Expired - Fee Related JP4579333B2 (ja) | 2007-02-02 | 2008-01-28 | 三環式化合物およびそれらのグルココルチコイド受容体調節剤としての使用 |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP2114888B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4579333B2 (cg-RX-API-DMAC7.html) |
| AP (1) | AP2411A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE487700T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008211622B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0807121A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2676907C (cg-RX-API-DMAC7.html) |
| DE (1) | DE602008003405D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2114888T3 (cg-RX-API-DMAC7.html) |
| EA (1) | EA016001B1 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20100726T1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL200044A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2009008286A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ578661A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2114888T3 (cg-RX-API-DMAC7.html) |
| SI (1) | SI2114888T1 (cg-RX-API-DMAC7.html) |
| UZ (1) | UZ4378C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008093236A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2114970E (pt) * | 2007-02-02 | 2011-09-22 | Pfizer Prod Inc | Compostos tricíclicos e sua utilização como moduladores de receptor de glucocorticóide |
| KR101377860B1 (ko) * | 2008-07-28 | 2014-03-25 | 화이자 인코포레이티드 | 페난트렌온 화합물, 조성물 및 방법 |
| UY33957A (es) * | 2011-03-15 | 2012-10-31 | Abbott Lab | Moduladores de los receptores de hormonas nucleares |
| WO2013040233A1 (en) * | 2011-09-13 | 2013-03-21 | New York University | Controlling regulatory t cell function |
| TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
| EP2935284A4 (en) | 2012-12-21 | 2016-04-27 | Abbvie Inc | HETEROCYCLIC MODULATORS OF HORMONE NUCLEAR RECEPTORS |
| UA120980C2 (uk) * | 2015-09-15 | 2020-03-10 | Лео Фарма А/С | Нестероїдні модулятори глюкокортикоїдних рецепторів для місцевої доставки ліків |
| CA3121719A1 (en) | 2018-12-19 | 2020-06-25 | Leo Pharma A/S | Amino-acid anilides as small molecule modulators of il-17 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE05584B1 (et) * | 1999-04-30 | 2012-10-15 | Pfizer Products Inc. | Glkokortikoidretseptori modulaatorid |
| JP4738603B2 (ja) * | 2000-11-06 | 2011-08-03 | ライオン株式会社 | 歯ブラシ |
| IL146057A (en) * | 2000-10-27 | 2007-09-20 | Pfizer Prod Inc | A process for the preparation of modulators of a non-steroidal glucocorticoid receptor |
| ES2262612T3 (es) * | 2000-10-28 | 2006-12-01 | Pfizer Products Inc. | Moduladpres del receptor de glucocorticoides. |
| JP2007511501A (ja) * | 2003-11-13 | 2007-05-10 | ファイザー・プロダクツ・インク | グルココルチコイド受容体調節剤として有用なオクタヒドロフェナンスレンヒドラジド誘導体 |
| WO2007131041A2 (en) * | 2006-05-02 | 2007-11-15 | Corcept Therapeutics, Inc. | The use of a glucocorticoid receptor ii antagonist to treat depression in patients taking il-2 |
-
2008
- 2008-01-28 BR BRPI0807121-7A2A patent/BRPI0807121A2/pt not_active Application Discontinuation
- 2008-01-28 MX MX2009008286A patent/MX2009008286A/es active IP Right Grant
- 2008-01-28 EA EA200970662A patent/EA016001B1/ru not_active IP Right Cessation
- 2008-01-28 WO PCT/IB2008/000249 patent/WO2008093236A1/en not_active Ceased
- 2008-01-28 NZ NZ578661A patent/NZ578661A/en not_active IP Right Cessation
- 2008-01-28 AP AP2009004941A patent/AP2411A/xx active
- 2008-01-28 AT AT08702358T patent/ATE487700T1/de active
- 2008-01-28 SI SI200830124T patent/SI2114888T1/sl unknown
- 2008-01-28 DK DK08702358.6T patent/DK2114888T3/da active
- 2008-01-28 DE DE602008003405T patent/DE602008003405D1/de active Active
- 2008-01-28 UZ UZ0900241A patent/UZ4378C/xx unknown
- 2008-01-28 JP JP2009547779A patent/JP4579333B2/ja not_active Expired - Fee Related
- 2008-01-28 CA CA2676907A patent/CA2676907C/en not_active Expired - Fee Related
- 2008-01-28 EP EP08702358A patent/EP2114888B1/en active Active
- 2008-01-28 AU AU2008211622A patent/AU2008211622B2/en not_active Ceased
- 2008-01-28 HR HR20100726T patent/HRP20100726T1/hr unknown
- 2008-01-28 PL PL08702358T patent/PL2114888T3/pl unknown
-
2009
- 2009-07-23 IL IL200044A patent/IL200044A/en active IP Right Grant