JP2010514413A5 - - Google Patents

Info

Publication number

JP2010514413A5

JP2010514413A5 JP2009542211A JP2009542211A JP2010514413A5 JP 2010514413 A5 JP2010514413 A5 JP 2010514413A5 JP 2009542211 A JP2009542211 A JP 2009542211A JP 2009542211 A JP2009542211 A JP 2009542211A JP 2010514413 A5 JP2010514413 A5 JP 2010514413A5

Authority

JP

Japan

Prior art keywords

antibody

antigen

seq

binding fragment

variant

Prior art date

2007-12-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000012634 fragment Substances 0.000 claims 30
• 239000000427 antigen Substances 0.000 claims 27
• 102000036639 antigens Human genes 0.000 claims 27
• 108091007433 antigens Proteins 0.000 claims 27
• 125000003275 alpha amino acid group Chemical group 0.000 claims 16
• 230000004927 fusion Effects 0.000 claims 16
• 239000003795 chemical substances by application Substances 0.000 claims 14
• 102100025320 Integrin alpha-11 Human genes 0.000 claims 9
• 101710123196 Integrin alpha-11 Proteins 0.000 claims 9
• 239000000833 heterodimer Substances 0.000 claims 7
• 210000004027 cell Anatomy 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
• 230000001684 chronic effect Effects 0.000 claims 2
• 230000011382 collagen catabolic process Effects 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 238000001727 in vivo Methods 0.000 claims 2
• 230000002757 inflammatory effect Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 208000024891 symptom Diseases 0.000 claims 2
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
• 208000011594 Autoinflammatory disease Diseases 0.000 claims 1
• 206010009900 Colitis ulcerative Diseases 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000012659 Joint disease Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
• 206010003246 arthritis Diseases 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 210000000845 cartilage Anatomy 0.000 claims 1
• 210000001612 chondrocyte Anatomy 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 230000006378 damage Effects 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 210000002950 fibroblast Anatomy 0.000 claims 1
• 238000003384 imaging method Methods 0.000 claims 1
• 230000004968 inflammatory condition Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 208000018937 joint inflammation Diseases 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 201000001245 periodontitis Diseases 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1