JP2010512747A - 筋疾患および心臓血管障害を処置するための組成物および方法 - Google Patents

筋疾患および心臓血管障害を処置するための組成物および方法 Download PDF

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JP2010512747A
JP2010512747A JP2009541384A JP2009541384A JP2010512747A JP 2010512747 A JP2010512747 A JP 2010512747A JP 2009541384 A JP2009541384 A JP 2009541384A JP 2009541384 A JP2009541384 A JP 2009541384A JP 2010512747 A JP2010512747 A JP 2010512747A
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nucleic acid
mir
seq
acid molecule
isolated nucleic
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JP2010512747A5 (cg-RX-API-DMAC7.html
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イワン・ブーフィンク
ジョナサン・ホール
ヤン・ヴァイラー
クリスチャン・シュネル
マティアス・ミューラー
マルティナ・シンケ−ブラウン
ファブリツィオ・セルルカ
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ノバルティス アーゲー
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2009541384A 2006-12-14 2007-12-13 筋疾患および心臓血管障害を処置するための組成物および方法 Withdrawn JP2010512747A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86993706P 2006-12-14 2006-12-14
PCT/US2007/025535 WO2008076324A2 (en) 2006-12-14 2007-12-13 Compositions and methods to treat muscular & cardiovascular disorders

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2011178297A Division JP2012019789A (ja) 2006-12-14 2011-08-17 筋疾患および心臓血管障害を処置するための組成物および方法
JP2012034691A Division JP2012131812A (ja) 2006-12-14 2012-02-21 筋疾患および心臓血管障害を処置するための組成物および方法

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JP2010512747A true JP2010512747A (ja) 2010-04-30
JP2010512747A5 JP2010512747A5 (cg-RX-API-DMAC7.html) 2011-02-03

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JP2009541384A Withdrawn JP2010512747A (ja) 2006-12-14 2007-12-13 筋疾患および心臓血管障害を処置するための組成物および方法
JP2011178297A Withdrawn JP2012019789A (ja) 2006-12-14 2011-08-17 筋疾患および心臓血管障害を処置するための組成物および方法
JP2012034691A Withdrawn JP2012131812A (ja) 2006-12-14 2012-02-21 筋疾患および心臓血管障害を処置するための組成物および方法

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JP2011178297A Withdrawn JP2012019789A (ja) 2006-12-14 2011-08-17 筋疾患および心臓血管障害を処置するための組成物および方法
JP2012034691A Withdrawn JP2012131812A (ja) 2006-12-14 2012-02-21 筋疾患および心臓血管障害を処置するための組成物および方法

Country Status (11)

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US (3) US20100280094A1 (cg-RX-API-DMAC7.html)
EP (1) EP2104733A2 (cg-RX-API-DMAC7.html)
JP (3) JP2010512747A (cg-RX-API-DMAC7.html)
KR (1) KR20090098818A (cg-RX-API-DMAC7.html)
CN (2) CN101563458A (cg-RX-API-DMAC7.html)
AU (1) AU2007334502B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0719995A2 (cg-RX-API-DMAC7.html)
CA (1) CA2672606A1 (cg-RX-API-DMAC7.html)
EA (2) EA201101361A1 (cg-RX-API-DMAC7.html)
MX (1) MX2009006310A (cg-RX-API-DMAC7.html)
WO (1) WO2008076324A2 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012516856A (ja) * 2009-02-04 2012-07-26 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 心臓障害の治療におけるmir−208およびmir−499の二重ターゲティング
JP2015536132A (ja) * 2012-10-15 2015-12-21 アイシス ファーマシューティカルズ, インコーポレーテッド C9orf72発現を調節するための組成物

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ES2397439T3 (es) 2006-08-01 2013-03-07 Board Of Regents Of The University Of Texas System Identificación de un microARN que activa la expresión de la cadena pesada beta de la miosina
CN101808649B (zh) 2007-07-31 2014-05-21 得克萨斯系统大学董事会 控制肌球蛋白表达和肌纤维身份的微小rna
IE20090047A1 (en) * 2009-02-26 2010-09-29 Nat Univ Ireland Protein targets in disease
AU2010224100B2 (en) * 2009-03-12 2015-10-22 Brandeis University Reagents and methods for PCR
AU2011343720A1 (en) 2010-12-15 2013-04-11 Miragen Therapeutics MicroRNA inhibitors comprising locked nucleotides
CA2850223A1 (en) 2011-10-06 2013-04-11 Eva Van Rooij Control of whole body energy homeostasis by microrna regulation
HK1209781A1 (en) 2012-06-21 2016-04-08 MiRagen Therapeutics, Inc. Oligonucleotide-based inhibitors comprising locked nucleic acid motif
EP2906697A4 (en) 2012-10-15 2016-06-22 Ionis Pharmaceuticals Inc METHOD FOR MONITORING THE C9ORF72 EXPRESSION
WO2014169126A1 (en) * 2013-04-10 2014-10-16 Reveragen Biopharma, Inc. Methods and agents to increase therapeutic dystrophin expression in muscle
CN112080502A (zh) 2013-10-11 2020-12-15 Ionis制药公司 用于调节c9orf72表达的组合物
WO2016022536A2 (en) * 2014-08-04 2016-02-11 MiRagen Therapeutics, Inc. Inhibitors of myh7b and uses thereof
BR112017015618A2 (pt) 2015-01-20 2018-04-10 Miragen Therapeutics Inc inibidores de mir-92 e usos destes.
PL3283080T3 (pl) 2015-04-16 2020-07-27 Ionis Pharmaceuticals, Inc. Kompozycja do modulowania ekspresji c9orf72
US11260073B2 (en) 2015-11-02 2022-03-01 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating C90RF72
CN106148519A (zh) * 2016-07-05 2016-11-23 无锡市第二人民医院 一种microRNA‑499的快速检测方法
US12054711B2 (en) 2017-07-14 2024-08-06 City Of Hope Meta-stable oligonucleotides junctions for delivery of therapeutics
EP3665281A4 (en) * 2017-08-10 2021-05-05 City of Hope CONDITIONAL SIRNA AND ITS USE IN THE TREATMENT OF CARDIAC HYERTROPHY
KR102281710B1 (ko) 2021-02-19 2021-07-28 조기정 에어튜브를 이용한 선박 안전장치
CN119246849B (zh) * 2024-12-09 2025-03-14 上海基灵生物科技有限公司 一种检测犬心脏损伤的试剂盒及应用

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ES2397439T3 (es) * 2006-08-01 2013-03-07 Board Of Regents Of The University Of Texas System Identificación de un microARN que activa la expresión de la cadena pesada beta de la miosina
CN101808649B (zh) * 2007-07-31 2014-05-21 得克萨斯系统大学董事会 控制肌球蛋白表达和肌纤维身份的微小rna

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012516856A (ja) * 2009-02-04 2012-07-26 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 心臓障害の治療におけるmir−208およびmir−499の二重ターゲティング
JP2015536132A (ja) * 2012-10-15 2015-12-21 アイシス ファーマシューティカルズ, インコーポレーテッド C9orf72発現を調節するための組成物
JP2019141075A (ja) * 2012-10-15 2019-08-29 アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. C9orf72発現を調節するための組成物
JP2021176329A (ja) * 2012-10-15 2021-11-11 アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals, Inc. C9orf72発現を調節するための組成物

Also Published As

Publication number Publication date
CN102604951A (zh) 2012-07-25
AU2007334502B2 (en) 2011-12-15
WO2008076324A3 (en) 2009-04-09
JP2012019789A (ja) 2012-02-02
JP2012131812A (ja) 2012-07-12
EA201101361A1 (ru) 2012-11-30
MX2009006310A (es) 2009-07-22
EP2104733A2 (en) 2009-09-30
AU2007334502A1 (en) 2008-06-26
BRPI0719995A2 (pt) 2014-03-18
US20100280094A1 (en) 2010-11-04
EA200900782A1 (ru) 2009-12-30
US20120114744A1 (en) 2012-05-10
WO2008076324A2 (en) 2008-06-26
CA2672606A1 (en) 2008-06-26
KR20090098818A (ko) 2009-09-17
CN101563458A (zh) 2009-10-21
US20120041052A1 (en) 2012-02-16

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