JP2010508029A5 - - Google Patents
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- JP2010508029A5 JP2010508029A5 JP2009534893A JP2009534893A JP2010508029A5 JP 2010508029 A5 JP2010508029 A5 JP 2010508029A5 JP 2009534893 A JP2009534893 A JP 2009534893A JP 2009534893 A JP2009534893 A JP 2009534893A JP 2010508029 A5 JP2010508029 A5 JP 2010508029A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- intron
- polymorphism
- genotype
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 238000000034 method Methods 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 12
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 8
- 206010042458 Suicidal ideation Diseases 0.000 claims 7
- 238000004458 analytical method Methods 0.000 claims 6
- 102100030652 Glutamate receptor 1 Human genes 0.000 claims 5
- 101001010445 Homo sapiens Glutamate receptor 1 Proteins 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 5
- 108700028369 Alleles Proteins 0.000 claims 4
- 102100022758 Glutamate receptor ionotropic, kainate 2 Human genes 0.000 claims 4
- 101000903346 Homo sapiens Glutamate receptor ionotropic, kainate 2 Proteins 0.000 claims 4
- 101000903313 Homo sapiens Glutamate receptor ionotropic, kainate 5 Proteins 0.000 claims 4
- 102000004310 Ion Channels Human genes 0.000 claims 4
- 108090000862 Ion Channels Proteins 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 238000000123 temperature gradient gel electrophoresis Methods 0.000 claims 4
- 102100035080 BDNF/NT-3 growth factors receptor Human genes 0.000 claims 3
- 102000018899 Glutamate Receptors Human genes 0.000 claims 3
- 108010027915 Glutamate Receptors Proteins 0.000 claims 3
- 102100029458 Glutamate receptor ionotropic, NMDA 2A Human genes 0.000 claims 3
- 102000017678 HTR3B Human genes 0.000 claims 3
- 101000964058 Homo sapiens 5-hydroxytryptamine receptor 3B Proteins 0.000 claims 3
- 101000596896 Homo sapiens BDNF/NT-3 growth factors receptor Proteins 0.000 claims 3
- 101001125242 Homo sapiens Glutamate receptor ionotropic, NMDA 2A Proteins 0.000 claims 3
- 108091027305 Heteroduplex Proteins 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 2
- 238000012300 Sequence Analysis Methods 0.000 claims 2
- 239000003398 denaturant Substances 0.000 claims 2
- 238000001502 gel electrophoresis Methods 0.000 claims 2
- 239000011544 gradient gel Substances 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 238000010208 microarray analysis Methods 0.000 claims 2
- 230000000508 neurotrophic effect Effects 0.000 claims 2
- 102000020233 phosphotransferase Human genes 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 229940076279 serotonin Drugs 0.000 claims 2
- 108010002164 tyrosine receptor Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- VLSMHEGGTFMBBZ-UHFFFAOYSA-N alpha-Kainic acid Natural products CC(=C)C1CNC(C(O)=O)C1CC(O)=O VLSMHEGGTFMBBZ-UHFFFAOYSA-N 0.000 claims 1
- 108010025843 glutamine receptor Proteins 0.000 claims 1
- VLSMHEGGTFMBBZ-OOZYFLPDSA-N kainic acid Chemical compound CC(=C)[C@H]1CN[C@H](C(O)=O)[C@H]1CC(O)=O VLSMHEGGTFMBBZ-OOZYFLPDSA-N 0.000 claims 1
- 229950006874 kainic acid Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85497806P | 2006-10-27 | 2006-10-27 | |
| PCT/US2007/082683 WO2008052167A2 (en) | 2006-10-27 | 2007-10-26 | Methods to identify patients at risk of developing adverse events during treatment with antidepressant medication |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010508029A JP2010508029A (ja) | 2010-03-18 |
| JP2010508029A5 true JP2010508029A5 (enExample) | 2010-12-16 |
Family
ID=39276298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534893A Withdrawn JP2010508029A (ja) | 2006-10-27 | 2007-10-26 | 抗うつ薬による治療時に有害事象を発現する危険性のある患者の識別方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7906283B2 (enExample) |
| EP (1) | EP2087136A2 (enExample) |
| JP (1) | JP2010508029A (enExample) |
| CA (1) | CA2667812A1 (enExample) |
| WO (1) | WO2008052167A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2166112B1 (en) * | 2008-09-18 | 2013-06-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Means and methods for diagnosing predisposition for treatment emergent suicidal ideation |
| CA2736936A1 (en) * | 2008-09-18 | 2010-03-25 | Andreas Menke | Means and methods for diagnosing predisposition for treatment emergent suicidal ideation (tesi) |
| CA2918054C (en) * | 2013-07-11 | 2022-12-13 | The Johns Hopkins University | A dna methylation and genotype specific biomarker of suicide attempt and/or suicide ideation |
| US11122997B2 (en) | 2015-04-17 | 2021-09-21 | Mayo Foundation For Medical Education And Research | Modulating the aryl hydrocarbon receptor system to treat major depressive disorder |
| CA2891830A1 (en) * | 2015-05-15 | 2016-11-15 | Centre For Addiction And Mental Health | Genetic markers for suicide risk and related methods |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002057790A2 (en) | 2001-01-19 | 2002-07-25 | Mindsense Biosystems Ltd. | Methods and compositions for diagnosing and treating a subject having depression |
| WO2003020982A1 (en) | 2001-08-29 | 2003-03-13 | Murphy Greer M | A method to determine the risk for side effects of an ssri treatment in a person |
| US8401801B2 (en) | 2003-02-20 | 2013-03-19 | Mayo Foundation For Medical Education And Research | Methods for selecting medications |
| US7374760B2 (en) * | 2003-05-15 | 2008-05-20 | The University Of Chicago | Methods and compositions for nerve regeneration |
| US20050069936A1 (en) | 2003-09-26 | 2005-03-31 | Cornelius Diamond | Diagnostic markers of depression treatment and methods of use thereof |
| WO2006076695A2 (en) | 2005-01-14 | 2006-07-20 | East Tennessee State University Research Foundation | Genetic screening for improving treatment of patients diagnosed with depression |
| US20080299125A1 (en) | 2006-06-05 | 2008-12-04 | Perlegen Sciences, Inc. | Genetic basis of treatment response in depression patients |
-
2007
- 2007-10-26 EP EP07868595A patent/EP2087136A2/en not_active Withdrawn
- 2007-10-26 WO PCT/US2007/082683 patent/WO2008052167A2/en not_active Ceased
- 2007-10-26 CA CA 2667812 patent/CA2667812A1/en not_active Abandoned
- 2007-10-26 JP JP2009534893A patent/JP2010508029A/ja not_active Withdrawn
- 2007-10-26 US US11/925,334 patent/US7906283B2/en not_active Expired - Fee Related
-
2011
- 2011-01-27 US US13/015,068 patent/US20110118133A1/en not_active Abandoned
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