JP2010246533A - Total nutritional food containing branched-chain amino acid - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a total nutritional food having shape retainability even after baked, capable of ameliorating the PEM (protein energy malnutrition) of patients suffered from cirrhosis such as those suffered from chronic hepatic failure accompanied by hepatic encephalopathy, usable as a LES (late evening snack) as well, and also enabling energy intake, by containing three kinds of branched-chain amino acids as active ingredients, in the form of baked confectionery, obtained by compounding the three kinds of branched-chain amino acids, i.e. isoleucine, leucine and valine, with dietary fibers and at least one protein material, i.e. casein sodium and/or concentrated soybean protein. <P>SOLUTION: The total nutritional food containing branched-chain amino acids includes 3.0-4.5 g, per 100 kcal of the branched-chain amino aids, at least one protein material, i.e. casein sodium and/or concentrated soybean protein, and dietary fibers; wherein the protein is 20-26 energy%; the lipid is 15-35 energy%; the shape retainability index after baked is 1.0-1.2; and the moisture content is 3-10 wt.%. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

The present invention relates to a comprehensive nutritive food in the form of a baked confectionery containing as active ingredients a branched chain amino acid of isoleucine, leucine and valine.
More specifically, the amount of the branched chain amino acid is 3.0 to 4.5 g per 100 kcal, at least one protein raw material of sodium caseinate or concentrated soy protein and dietary fiber are blended, the protein is 20 to 26 energy%, the lipid Is 15 to 35 energy%, the shape retention after baking is 1.0 to 1.15, and the moisture content is related to a branched chain amino acid-containing comprehensive nutritional food with 3 to 10% by weight.

In patients with cirrhosis, protein and energy malnutrition (PEM) frequently occurs due to protein and energy metabolism abnormalities, and lack of both protein and energy. Abnormal energy metabolism is thought to be due to a decrease in glycogen storage due to atrophy of the liver and poor glucose uptake in peripheral tissues due to insulin resistance. In particular, when the stomach is hungry early in the morning, there is an abnormality in the burning rate of the energy substrate, the burning rate of carbohydrates decreases, and the burning rate of lipids increases. It is said that the early morning starvation state of cirrhosis patients corresponds to the metabolic state at the time of fasting for 2-3 days in healthy persons. For the purpose of avoiding this starvation state, it has been clarified that the energy metabolism abnormality is improved by administering a divided meal or a night evening snack (LES) (Non-Patent Document 1).
In addition, branched-chain amino acids have been administered to improve the low protein nutritional status of cirrhotic patients. It has also been reported that administration of branched chain amino acids at night or before going to bed is more advantageous for protein synthesis (Non-patent Document 2). That is, it has been proven that when both branched-chain amino acids and energy are administered preferentially at night or before going to bed, they are useful for improving protein and energy metabolism in cirrhotic patients.

For this reason, it is considered that a preparation containing three kinds of branched chain amino acids of isoleucine, leucine and valine as active ingredients and capable of taking energy is effective in improving the nutritional status of cirrhotic patients. Currently, for the purpose of improving the nutritional status of patients with chronic liver failure associated with hepatic encephalopathy, a preparation containing three kinds of branched chain amino acids, carbohydrates, lipids and the like is commercially available. At the time of ingestion, the granules are dissolved in water to form a liquid (Amino Levan (registered trademark) EN, Hepan ED (registered trademark)), or are in a liquid state in advance (Hepas, Hepas II). All of the preparations are in a liquid form and are accompanied by water intake. When these preparations are used as LES, there is a problem that abdominal fullness or stomach sag is present, sleep is disturbed, and nighttime toilet time due to water intake before going to bed is painful (Non-patent Document 3). ). In particular, the elderly had problems from the viewpoint of administration.
Therefore, it was considered that a solid product is suitable as a preparation that contains a branched chain amino acid as an active ingredient, can consume energy, and has as little water content as possible, and the form of baked confectionery is optimal. However, when a baked confectionery containing a large amount of branched chain amino acids is prepared by a conventional method of preparing a baked confectionery, shape retention is lost during the preparation and it is difficult to prepare. There was no effective means to meet all of these requirements.

Hisaki Moriwaki, Nutritional Evaluation and Treatment, 23 (1), 2006, pp. 79-81. Hideki Fukushima, Hepatobiliary pancreas, 50 (5), 2005, pp. 739-747. Nutritional Evaluation and Treatment, 24 (3), 2007, pp. 64-73.

  The object of the present invention is to improve the PEM of cirrhosis patients such as chronic liver failure patients with hepatic encephalopathy, which is made in view of the above situation, and can be used as LES, and branched chain amino acids are effective. The present invention provides a branched chain amino acid-containing comprehensive nutritional food in the form of a baked confectionery that can be consumed as an ingredient.

  As a result of intensive studies to achieve the above object, the present inventors have found that three branched chain amino acids of isoleucine, leucine and valine, which are active ingredients, contain at least one protein raw material of sodium caseinate or concentrated soybean protein and By blending dietary fiber, it has been found that a branched chain amino acid-containing comprehensive nutritional food in the form of a baked confectionery having shape retention after baking can be obtained, and the present invention has been completed based on this finding.

That is, this invention is shown to the following (1)-(7).
(1) Comprehensive nutritional food in the form of a baked goods confectionery containing isoleucine, leucine and valine branched chain amino acids, wherein the amount of the three branched chain amino acids is 3.0 to 4.5 g per 100 kcal, sodium caseinate or concentrated Contains at least one protein raw material and dietary fiber of soy protein, protein is 20-26 energy%, lipid is 15-35 energy%, shape retention after baking is 1.0-1.15, moisture A branched chain amino acid-containing comprehensive nutritional food having an amount of 3 to 10% by weight.
(2) The branched chain amino acid-containing comprehensive nutritional food according to (1), wherein the protein raw material is 0.05 to 0.3 parts by weight with respect to 1 part by weight of the total of branched chain amino acids of isoleucine, leucine and valine.
(3) The branched-chain amino acid content according to (1) or (2) above, wherein the dietary fiber is at least one of guar gum enzyme degradation product, cellulose, psyllium seed coat, corn fiber, resistant starch, wheat bran, or inulin General nutrition food.
(4) The branch according to any one of (1) to (3) above, wherein the dietary fiber is 0.1 to 0.5 parts by weight with respect to 1 part by weight of the total of branched chain amino acids of isoleucine, leucine and valine. General nutrition food containing chain amino acids.
(5) The blending ratio of isoleucine, leucine and valine is 0.9 to 1.1: 1.8 to 2.2: 0.9 to 1.1, and any one of (1) to (4) above A comprehensive nutritional food containing branched-chain amino acids.
(6) The branched chain amino acid-containing comprehensive nutritional food according to any one of (1) to (5), wherein vitamins and minerals are blended.
(7) The branched chain amino acid-containing comprehensive nutritional food according to any one of (1) to (6), which contains substantially no iron compound.

  As described above, the branched chain amino acid-containing comprehensive nutritional food of the present invention comprises at least one protein raw material and food of sodium casein or concentrated soy protein in addition to the three branched chain amino acids isoleucine, leucine and valine as active ingredients. By blending the fiber, it has shape retention after firing. Can be used as LES because it can improve PEM in cirrhotic patients such as chronic liver failure patients with hepatic encephalopathy and does not involve excessive water intake when taking branched chain amino acid-containing total nutrition It is also possible to provide a branched chain amino acid-containing comprehensive nutritional food in the form of a baked confectionery that contains a branched chain amino acid as an active ingredient and can also consume energy.

Hereinafter, the branched chain amino acid-containing comprehensive nutritional food of the present invention will be described in detail.
The “baked goods confectionery” shown in the present invention means a product obtained by shaping a dough and then heating and baking it. The raw materials used for the dough can be any of those conventionally used when preparing baked goods, for example, flour, sugar, edible oils and fats as the main raw materials, if necessary, salt, dairy products, Eggs, swelling agents, etc. are added. Representative examples of the baked goods that meet this purpose include cookies, biscuits, and sachets.

The “shape-retaining property” of the present invention refers to a pre-baked dough that is formed into a disk shape by cutting a dough stretched into a uniform plate shape having a thickness of 4 to 8 mm using a die having a diameter of 5.5 to 8 cm. The size (area) is 1, and it means the change value when the area ratio of the branched chain amino acid-containing comprehensive nutritional food after baking is measured using image analysis software.
Examples of the image analysis software used when measuring the area ratio in the present invention include Scion Image (Scion Corporation).
The branched chain amino acid used in the branched chain amino acid-containing comprehensive nutritional food of the present invention is not particularly limited as long as it satisfies the standards of the Food Additives Official Document.

  The amount of the branched chain amino acid blended in the branched chain amino acid-containing comprehensive nutritional food of the present invention is in the range of 3.0 to 4.5 g, preferably 3.5 to 4.3 g per 100 kcal. If the amount of the branched chain amino acid is less than 3.0 g, the target branched chain amino acid amount cannot be taken, which is not preferable. On the other hand, if it exceeds 4.5 g, the baked baked goods do not have sufficient shape retention, which is not preferable as a food.

As the shape-retaining protein used for imparting shape retention used in the branched chain amino acid-containing comprehensive nutritional food of the present invention, at least one of sodium casein and concentrated soy protein is required.
The amount of sodium caseinate or concentrated soybean protein to be blended in the branched chain amino acid-containing general nutritional food of the present invention is preferably 0.05 to 0.3 with respect to 1 part by weight of the total of branched chain amino acids of isoleucine, leucine and valine. Parts by weight, more preferably 0.1 to 0.2 parts by weight. When the amount of sodium caseinate or concentrated soybean protein is less than 0.05 parts by weight, the baked baked goods do not have sufficient shape retention, which is not preferable as a food. Moreover, since it will become hard and it will become difficult to eat when it exceeds 0.3 weight part, it is unpreferable.

A protein raw material conventionally used in foods may be blended with the branched chain amino acid-containing comprehensive nutritional food of the present invention, other than sodium caseinate or concentrated soy protein, within the range not departing from the gist of the present invention. Examples of protein materials other than sodium caseinate or concentrated soy protein include plant protein materials such as soy protein, concentrated soy protein, wheat protein, and corn gluten meal. Examples of animal protein materials include dairy products such as milk and skim milk, casein other than sodium caseinate, whey, total milk protein (TMP), and milk protein concentrate (MPC). Examples include milk protein, egg white, collagen, protamine and the like. In particular, whey with a high content of branched chain amino acids of isoleucine, leucine and valine is preferable in terms of nutrition.
The ratio of the protein in the branched chain amino acid-containing comprehensive nutritional food of the present invention is in the range of 20 to 26 energy%, preferably 22 to 25 energy%. If the ratio of the protein is less than 20% by energy, the target protein mass cannot be ingested, which is not preferable. Moreover, since it will become hard and it will become difficult to eat when it exceeds 26 energy%, it is not preferable as a foodstuff.

The branched chain amino acid-containing comprehensive nutritional food of the present invention requires a shape-retaining dietary fiber used for imparting shape retention. As dietary fiber to be blended, various known dietary fibers conventionally used in foods can be used singly or in combination of two or more. For example, water-soluble dietary fiber such as guar gum enzyme degradation product, low molecular weight sodium alginate, glucomannan, inulin, apple dietary fiber, corn fiber, resistant starch, psyllium seed coat, beet fiber, apple fiber, sugarcane dietary fiber, wheat bran And insoluble dietary fiber such as fermented barley fiber, pea fiber, evening fruit fruit dietary fiber, citrus fiber, cellulose, wheat fiber, oat fiber, potato fiber, soybean fiber and the like. Among these dietary fibers, it is particularly preferable to use at least one of guar gum enzyme degradation product or cellulose, psyllium seed coat, corn fiber, resistant starch, wheat bran, or inulin.
The amount of dietary fiber to be blended in the branched chain amino acid-containing comprehensive nutritional food of the present invention is 0.1 to 0.5 parts by weight, preferably 0, per 1 part by weight of the total of branched chain amino acids of isoleucine, leucine and valine. The range is from 2 to 0.4 parts by weight. When the blending amount of dietary fiber is less than 0.1 parts by weight, the baked baked goods do not have sufficient shape retention, which is not preferable as a food. Moreover, since it will become hard and it will become difficult to eat when it exceeds 0.5 weight part, it is unpreferable.

As the lipid blended in the branched chain amino acid-containing comprehensive nutritional food of the present invention, various known edible fats and oils that have been conventionally used in foods can be used singly or in combination of two or more. For example, linseed oil, sesame oil, olive oil, sesame oil, rice oil, rice bran oil, safflower oil, perilla oil, soybean oil, corn oil, rapeseed oil, germ oil, palm oil, palm kernel oil, sunflower oil, cottonseed oil, palm Vegetable oils such as oil, nut oil, peanut oil, cacao butter, animal oils such as lard, beef tallow, fish oil, milk fat, medium chain fatty acids, highly unsaturated fatty acids, processed oils such as DHA, EPA, diacylglycerol. Moreover, fats and oils processed products, such as butter, margarine, and shortening containing these fats and oils are mentioned.
The proportion of lipid in the branched chain amino acid-containing comprehensive nutritional food of the present invention is in the range of 15 to 35 energy%, preferably 15 to 30 energy%. If the protein ratio is less than 15 energy%, the target lipid amount cannot be taken, which is not preferable. Moreover, when it exceeds 35 energy%, the amount of lipid to ingest increases and it is not preferable as a comprehensive nutrition food.

As the carbohydrate used in the branched chain amino acid-containing comprehensive nutritional food of the present invention, any of various known substances that have been conventionally used in foods can be used. For example, monosaccharides such as glucose (glucose), lactose (lactose), fructose (fructose), disaccharides such as sucrose, granulated sugar, maltose, trehalose, maltose, isomaltose, glycogen, dextrin, starch (wheat starch etc.) Polysaccharides, chickenpox, reduced starch syrup, honey, isomerized sugar, invert sugar, oligosaccharide (isomaltooligosaccharide, reduced xylo-oligosaccharide, reduced gentio-oligosaccharide, xylo-oligosaccharide, gentio-oligosaccharide, nigerooligosaccharide, theande-oligosaccharide, soybean oligosaccharide, etc.) , Powdered sugar, sugar alcohol (maltitol, erythritol, sorbitol, palatinit, xylitol, lactitol, etc.), sugar-bound starch syrup (coupling sugar) and the like. These may be used alone or in combination of two or more.
In addition, conventionally known or future sweet ingredients can also be used in place of sugars. Specifically, sweet ingredients such as aspartame, acesulfame potassium, sucralose, alitame, neotame, licorice extract (glycyrrhizin), saccharin, saccharin sodium, stevia extract, stevia powder, etc. may be used, but the above-mentioned lipids and proteins As is apparent from the description regarding energy%, the sugar content of the branched chain amino acid-containing comprehensive nutritional food of the present invention is 39 to 65 energy%. Therefore, the sweetener component is formulated with attention to the energy% of the sugar. There is a need.

When producing the branched chain amino acid-containing comprehensive nutritional food of the present invention, components such as appropriate vitamins and minerals that are usually used can be blended depending on the type of product.
The vitamins used in the branched chain amino acid-containing comprehensive nutritional food of the present invention include vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, pantothenic acid, folic acid, biotin, vitamin C, vitamin A, vitamin D, vitamin E, Vitamin K and the like can be mentioned, and it is preferable to combine a plurality of these as much as possible. A vitamin derivative may be used as the vitamin.
As the amount of the vitamin, the following range is appropriate per 100 kcal of the branched chain amino acid-containing comprehensive nutritional food.
Vitamin B1 0.1-40 mg, preferably 0.3-25 mg
Vitamin B2 0.1-20 mg, preferably 0.33-12 mg
Vitamin B6 0.1-60 mg, preferably 0.3-10 mg
Vitamin B12 0.1-100 μg, preferably 0.60-60 μg
Niacin 1-300 mg, preferably 3.3-60 mg
Pantothenic acid 0.1-55 mg, preferably 1.65-30 mg
Folic acid 10-1000 μg, preferably 60-200 μg
Biotin 1-1000 μg, preferably 14-500 μg
Vitamin C 10-2000 mg, preferably 24-1000 mg
Vitamin A 0-3000 μg, preferably 135-600 μg
Vitamin D 0.1-50 μg, preferably 1.5-5.0 μg
Vitamin E 1-800 mg, preferably 2.4-150 mg
Vitamin K 0.5-1000 μg, preferably 2-700 μg

Examples of the minerals used in the branched chain amino acid-containing comprehensive nutritional food of the present invention include sodium, potassium, calcium, magnesium, phosphorus, and zinc, and it is preferable to combine a plurality of these as much as possible. These may be mix | blended as an inorganic electrolyte component, and may be mix | blended as an organic electrolyte component. Examples of the inorganic electrolyte component include alkali metal or alkaline earth metal salts such as chlorides, sulfates, carbonates, and phosphorus oxides. The organic electrolyte component includes an organic acid such as citric acid, lactic acid, amino acid (such as glutamic acid and aspartic acid), alginic acid, malic acid or gluconic acid and an inorganic base such as an alkali metal or alkaline earth metal. Examples include salts. For example, calcium chloride, calcium citrate, calcium glycerophosphate, calcium gluconate, calcium hydroxide, calcium stearate, calcium stearoyl lactate, calcium carbonate, calcium lactate, dihydrogen pyrophosphate, calcium sulfate, tricalcium phosphate, monophosphate Examples include calcium hydrogen, calcium dihydrogen phosphate, uncalcined calcium, magnesium chloride, magnesium stearate, magnesium carbonate, magnesium sulfate, trimagnesium phosphate, zinc gluconate, and zinc sulfate.
As the blending amount of the mineral, the following range is appropriate per 100 kcal of the branched chain amino acid-containing comprehensive nutritional food.
Sodium 5-6000mg, preferably 10-3500mg
Potassium 1-3500 mg, preferably 25-1800 mg
Magnesium 1-740 mg, preferably 25-300 mg
Calcium 10-2300 mg, preferably 250-600 mg
Phosphorus 1-3500 mg, preferably 25-1500 mg
Zinc 0.1-30mg, preferably 1-15mg

The branched chain amino acid-containing comprehensive nutritional food of the present invention contains various additives used for the purpose of increasing nutritional value, imparting flavor, or coloring, as necessary, in addition to the main component. Furthermore, it can contain. Examples of the additives include flavors for the purpose of imparting flavor (synthetic flavors and natural flavors), soy sauce, miso, chemical seasonings, flavor substances (cheese, chocolate, etc.), caramels for coloring purposes, natural Other examples include emulsifiers (glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, sucrose fatty acid ester, lecithin, etc.), stabilizers, preservatives, and the like. These additives can be used either individually or in combination of two or more.
In addition, salt, yeast, an enzyme, a swelling agent, etc. can also be added to the branched chain amino acid containing comprehensive nutritional food of the present invention as needed. Examples of the enzyme include various proteases, amylases, cellulases and the like that are generally well known for confectionery. Examples of the swelling agent include those commonly used in the food industry, such as sodium bicarbonate and ammonium bicarbonate, and those containing these. A typical example is a commercially available baking powder. The amount of salt, yeast, enzyme, swelling agent and the like to be added can be the same as the amount in which they are usually added, and can generally be up to about 1% by weight.

In the method for producing a branched chain amino acid-containing comprehensive nutritional food according to the present invention, first, a dough containing each of the above components is prepared. This can be done by mixing a predetermined amount of each of the above components with water and kneading the mixture.
Preparation of the dough by mixing and kneading each of the above components can be performed appropriately using ordinary equipment, conditions and the like so that the obtained dough becomes uniform. For example, first, powdery raw material components are weighed and mixed, and a liquid animal protein material (milk, whole egg, etc.) containing a lot of water and moisture is mixed into the mixed powder. At this time, the water and liquid protein material can be preheated to about 50 ° C., and the temperature of the resulting fabric is raised to about 30 to 35 ° C. to soften the fabric, and the subsequent fabric Can be easily formed.
In the present invention, the dough obtained above is then shaped into an arbitrary shape. This shaping is performed according to a normal method, for example, using a rolling pin, a depositor, a rolling roller or the like to stretch the dough and perform die cutting. The shape at that time can be arbitrary. Considering the ease of production, the ease of eating the resulting food, etc., it is usually desirable to use a plate-like body having a thickness of about 4 to 8 mm. The size and length of these shaped products may be appropriately determined in consideration of the ease of eating and handling of the final product. The fabric may be cut as necessary.
In the present invention, it is indispensable to heat and bake the dough, thereby obtaining a comprehensive nutritional food in the form of a baked confectionery object of the present invention having shape retention and high content of branched chain amino acids.

The conditions for heating and baking can be appropriately selected according to the raw material used, the moisture content of the dough, and the like, and are not particularly different from those generally employed in confectionery production. Usually, the heating temperature range is selected from the range of about 60 to 250 ° C., and the heating time is selected from the range of about 2 to 60 minutes. Particularly preferred temperatures and times are about 160-220 ° C. and about 8-15 minutes.
The heat source for the heating and firing is not particularly limited, and those using combustion heat such as hot water, steam, electric heaters, gas ovens, microwave ovens, microwaves, far infrared rays, infrared rays, etc. Can be used.
In the production of the present invention, based on the composition range described above, the present invention can be further obtained by using a method conventionally known as a production method of Examples and baked goods described later, or a method newly provided in the future. The desired branched chain amino acid-containing comprehensive nutritional food can be produced.

The shape retention of the branched chain amino acid-containing comprehensive nutritional food of the present invention is in the range of 1.0 to 1.15. If the shape retention of the branched-chain amino acid-containing comprehensive nutritional food is less than 1.0, the branched-chain amino acid-containing comprehensive nutritional food becomes hard and difficult to eat. On the other hand, if it exceeds 1.15, the baked baked goods do not have sufficient shape retention, which is not preferable as a food.
The water content of the branched chain amino acid-containing general nutritional food of the present invention is 3 to 10% by weight, preferably 4 to 8% by weight. If the water content of the branched chain amino acid-containing general nutritional food is less than 3% by weight, the branched chain amino acid-containing general nutritional food becomes hard and difficult to eat. It is not preferable. On the other hand, if it exceeds 10% by weight, it is not suitable for long-term storage.

  The thus obtained branched chain amino acid-containing comprehensive nutritional food contains at least one protein raw material and dietary fiber of sodium casein or concentrated soy protein in the three branched chain amino acids of isoleucine, leucine and valine which are active ingredients. By blending, it retains its shape after firing, can improve PEM in patients with cirrhosis such as chronic liver failure patients with hepatic encephalopathy, can also be used as LES, and ingests branched chain amino acids and energy can do.

EXAMPLES Next, although an Example is given and this invention is demonstrated further in detail, this invention is not limited to these.
Example 1
Based on the formulation shown in Table 1, a branched chain amino acid-containing comprehensive nutritional food was obtained by the method of Preparation Method 1. In addition, the composition of the vitamin mix in Table 1 is as shown in Table 2. The resulting branched chain amino acid-containing general nutritional food had a shape retention of 1.11 and a moisture content of 6.3 wt%.

(Preparation method 1)
Margarine (Bronte, ADEKA Co., Ltd.), granulated sugar and emulsifier (Sunsoft No. 818H, Taiyo Kagaku Co., Ltd.) are placed in a 4.8 L stainless steel bowl and a mixer (KitchenAid model: KSM5, flat beater, F. Co., Ltd.) Mixing was performed at a speed scale of 2 minutes for 2 minutes. Next, frozen whole eggs (for confectionery, QP Corporation) were added and mixed for 2 minutes at a speed scale of 2. Furthermore, after adding microcalmag S, vitamin mix and zinc gluconate, mixing at speed scale 2 for 3 minutes, leucine, isoleucine, valine (L-leucine, L-isoleucine, L-valine, all Kyowa Hakko Bio Co., Ltd.) Company), dietary fiber (guar gum enzyme degradation product, Sunfiber R, Taiyo Kagaku Co., Ltd.), concentrated soy protein (ARCON S, Nippon Shinyaku Co., Ltd.) and whey protein (Lacprodan DI-9224, Arafu's Ingredients Japan) Company) was added and mixed on speed scale 1 for 30 seconds and speed scale 2 for 30 seconds. Finally, wheat flour (Nisshin Flour flour, Nisshin Foods Co., Ltd.) was added and mixed with a speed scale 1 for 30 seconds and a speed scale 2 for 1 minute to prepare a dough for a branched chain amino acid-containing comprehensive nutrition food. . The obtained dough was stretched into a uniform plate shape having a thickness of 7 mm with a rolling pin, and was cut out with a die having a diameter of 6 cm. Then, the die cut dough was baked at 170 ° C. for 11 minutes in an microwave oven (product number: NE-M250, Matsushita Electric Industrial Co., Ltd.) to obtain a branched chain amino acid-containing comprehensive nutritional food.

(Evaluation method 1)
The shape retention of the branched chain amino acid-containing comprehensive nutritional foods of Examples 1 to 3 and the samples of Comparative Examples 1 to 4 is the branched chain amino acid-containing comprehensive nutrition after baking when the size (area) before baking is set to 1. The area ratio of food was measured by setting a threshold value with the Threshold function using image analysis software (Scion Image, Scion Corporation), performing binarization processing. The measurement was performed at n = 3, and the result was shown as an average value. The results are shown in Table 3.
(Evaluation method 2)
The moisture content of the branched chain amino acid-containing comprehensive nutritional food of Examples 1 to 3 and the samples of Comparative Examples 1 to 4 was 110 ° C. using an infrared moisture meter (model number: AD-4715, A & D Co., Ltd.). Measured with The measurement was performed at n = 3, and the results were shown as average values. The results are shown in Table 3.

(Example 2)
In Example 1, except that the concentrated soybean protein was changed to sodium caseinate (Nippon Shinyaku Co., Ltd.), the same preparation method as in Example 1 was repeated to obtain a branched chain amino acid-containing comprehensive nutritional food. The resulting branched chain amino acid-containing general nutritional food had a shape retention of 1.10 and a water content of 6.8% by weight. The results are shown in Table 3.
(Comparative Example 1)
A sample was obtained by repeating exactly the same preparation method as in Example 1, except that the concentrated soybean protein was changed to calcium caseinate S (Nihon Shinyaku Co., Ltd.) in Example 1. The shape retention property of the obtained sample was 1.35, and the water content was 7.2% by weight. The results are shown in Table 3.
(Comparative Example 2)
A sample was obtained by repeating exactly the same preparation method as in Example 1, except that all the concentrated soybean protein and whey protein were changed to whey protein in Example 1. The shape retention property of the obtained sample was 1.36, and the water content was 7.1% by weight. The results are shown in Table 3.

(Example 3)
In Example 1, except that the dietary fiber was changed to insoluble dietary fiber (cellulose, Theolas (registered trademark), Asahi Kasei Chemicals Co., Ltd.), the same preparation method as in Example 1 was repeated to obtain a branched chain amino acid-containing comprehensive nutritional food. Obtained. The obtained branched chain amino acid-containing comprehensive nutritional food had a shape retention of 1.11 and a moisture content of 7.0% by weight. The results are shown in Table 3.
Example 4
In Example 1, the same preparation method as in Example 1 was repeated except that the dietary fiber was changed to a water-soluble / insoluble mixed dietary fiber (silium seed coat, healthy gum (registered trademark), Dainippon Sumitomo Pharma Co., Ltd.). A comprehensive nutritional food containing branched chain amino acids was obtained. The obtained branched-chain amino acid-containing comprehensive nutritional food had a shape retention of 1.06 and a moisture content of 5.0% by weight. The results are shown in Table 3.
(Example 5)
In Example 1, the same preparation method as in Example 1 was repeated except that the dietary fiber was changed to insoluble dietary fiber (corn fiber, solar eclipse, Nippon Shokuhin Kako Co., Ltd.). Obtained. The resulting branched chain amino acid-containing general nutritional food had a shape retention of 1.04 and a water content of 4.9% by weight. The results are shown in Table 3.
(Example 6)
In Example 1, the same preparation method as in Example 1 was repeated except that the dietary fiber was changed to insoluble dietary fiber (resistant starch, solar eclipse roadster, Nippon Shokuhin Kako Co., Ltd.). Got. The obtained branched-chain amino acid-containing comprehensive nutritional food had a shape retention of 1.10 and a water content of 5.2% by weight. The results are shown in Table 3.
(Example 7)
In Example 1, except that the dietary fiber is changed to insoluble dietary fiber (wheat bran, blanc ace powder P, Nippon Flour Mills Co., Ltd.), the same preparation method as in Example 1 is repeated to obtain a branched chain amino acid-containing comprehensive nutritional food. Got. The resulting branched chain amino acid-containing general nutritional food had a shape retention of 1.06 and a moisture content of 4.6% by weight. The results are shown in Table 3.
(Example 8)
In Example 1, except that the dietary fiber was changed to water-soluble dietary fiber (Inulin, Fibrin Instant, Sanei Saccharification Co., Ltd.), the same preparation method as in Example 1 was repeated to obtain a branched chain amino acid-containing comprehensive nutritional food. . The obtained branched chain amino acid-containing general nutritional food had a shape retention of 1.12 and a water content of 4.9% by weight. The results are shown in Table 3.
(Comparative Example 3)
In Example 1, a sample was obtained by repeating exactly the same preparation method as in Example 1 except that dietary fiber was not blended. The shape retention property of the obtained sample was 1.24, and the water content was 5.6% by weight. The results are shown in Table 3.
(Comparative Example 4)
In Example 1, a sample was obtained by repeating exactly the same preparation method as in Example 1 except that the dietary fiber was changed to water-soluble dietary fiber (indigestible dextrin, pine fiber, Matsutani Chemical Co., Ltd.). The shape retention property of the obtained sample was 1.32 and the water content was 6.8% by weight. The results are shown in Table 3.
(Comparative Example 5)
In Example 1, exactly the same preparation method as in Example 1 except that dietary fiber was changed to water-soluble dietary fiber (water-soluble soybean polysaccharide, Soya Five (registered trademark) -S-ZR100, Fuji Oil Co., Ltd.). Samples were obtained repeatedly. The shape retention property of the obtained sample was 1.16, and the water content was 7.0% by weight. The results are shown in Table 3.
(Comparative Example 6)
In Example 1, a sample was obtained by repeating exactly the same preparation method as in Example 1, except that the dietary fiber was changed to water-soluble dietary fiber (Polydextrose, Lightes Ultra (Lightes III), Danisco Japan Co., Ltd.). . The shape retention property of the obtained sample was 1.20, and the water content was 4.5% by weight. The results are shown in Table 3.
(Comparative Example 7)
A sample was obtained by repeating exactly the same preparation method as in Example 1, except that the dietary fiber was changed to water-soluble dietary fiber (Gum Arabic, Gum Arabic A, Ina Food Industry Co., Ltd.) in Example 1. The shape retention property of the obtained sample was 1.19, and the water content was 5.0% by weight. The results are shown in Table 3.
(Comparative Example 8)
A sample was obtained by repeating exactly the same preparation method as in Example 1, except that the dietary fiber was changed to a water-soluble / insoluble mixed dietary fiber (Agar, Ina Food Industry Co., Ltd.). The shape retention property of the obtained sample was 1.25, and the water content was 5.3% by weight. The results are shown in Table 3.

  The present invention provides shape retention after baking by blending at least one protein raw material of sodium casein or concentrated soy protein and dietary fiber with three branched chain amino acids of isoleucine, leucine and valine which are active ingredients. Branched-chain amino acids in the form of baked goods that can improve PEM of cirrhosis patients such as chronic liver failure patients with hepatic encephalopathy, can also be used as LES, have branched-chain amino acids as active ingredients, and can consume energy It is related to the contained comprehensive nutritional food and can be used industrially.

Claims (7)

  It is a comprehensive nutritional food in the form of a baked confectionery containing the branched chain amino acids of isoleucine, leucine and valine, the amount of the three types of branched chain amino acids is 3.0-4.5 g per 100 kcal, and the protein is a protein for shape retention It contains at least one of sodium caseinate or concentrated soy protein, further contains dietary fiber for shape retention, the protein is 20-26 energy%, the lipid is 15-35 energy%, and the shape retention after baking is A branched chain amino acid-containing comprehensive nutritional food having a water content of 1.0 to 1.15 and a water content of 3 to 10% by weight.   The branched-chain amino acid-containing comprehensive nutritional food according to claim 1, wherein the shape-retaining protein material is 0.05 to 0.3 parts by weight with respect to 1 part by weight of the total of branched-chain amino acids of isoleucine, leucine and valine.   The branched-chain amino acid-containing comprehensive nutrition food according to claim 1 or 2, wherein the shape-retaining dietary fiber is at least one of guar gum enzyme degradation product, cellulose, psyllium seed coat, corn furber, resistant starch, wheat bran, or inulin. .   The branched chain amino acid according to any one of claims 1 to 3, wherein the shape-retaining dietary fiber is 0.1 to 0.5 parts by weight with respect to 1 part by weight of a total of branched chain amino acids of isoleucine, leucine and valine. Contains comprehensive nutritional food.   The branched chain amino acid-containing synthesis according to any one of claims 1 to 4, wherein the blending ratio of isoleucine, leucine and valine is 0.9 to 1.1: 1.8 to 2.2: 0.9 to 1.1. Nutritional food.   The branched chain amino acid-containing comprehensive nutritional food according to any one of claims 1 to 5, wherein vitamins and minerals are blended.   The branched chain amino acid-containing comprehensive nutritional food according to any one of claims 1 to 6, which contains substantially no iron compound.