JP2010194225A - Syringe needle and use method of syringe needle - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a syringe needle, even if introducing the syringe needle into a phase-separated specimen, capable of injecting a component into a lower phase or extracting a component from the lower phase without being affected by the upper phase; and to provide a use method of the syringe needle. <P>SOLUTION: This syringe needle 1 including a hollow cylindrical section 4 and a distal end 3, further includes an opening/closing device 2 at an opening section which is present at a side face of the cylindrical section 4 or the distal end 3. Alternatively, this use method includes steps for: introducing the syringe needle 1 into the specimen having the upper phase consisting of a solid or liquid, and the lower phase located below the upper phase and consisting of liquid; opening/closing the opening/closing device 2 of the syringe needle 1 in the lower phase and; injecting the component into the lower phase or extracting the component from the lower phase. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a syringe needle and a method for using the syringe needle. Specifically, even if the syringe needle is introduced into a phase-separated sample, the liquid is injected into the lower phase or from the lower phase without being affected by the upper phase. The present invention relates to a syringe needle that can extract the components of and a method of using the syringe needle.

  Traditionally, syringe needles are used for liquid injection or component extraction. In particular, it is used very often in the medical field, and various syringe needles have been proposed.

  For example, Patent Document 1 includes one or more openings that fluidly connect the inner hole to the outside of the injection needle, and at least a part of the at least one opening is a cylindrical portion and / or an elongated portion. A needle on the side or on top is disclosed. Thus, by having the opening on the side surface, after injecting the injection needle, the liquid can be injected through the opening.

Japanese Patent Laying-Open No. 2005-523082 (Claims etc.)

  As described in Patent Document 1, when a liquid is injected by inserting an injection needle into the skin, the skin is a solid solid, so that there is no possibility that the skin enters the inside of the injection needle from the opening of the injection needle. However, in the case of liquid-liquid separation or solid-liquid separation, components may enter the injection needle depending on the state of the upper phase liquid or solid in the case of extraction. FIG. 5 is a cross-sectional view showing a conventional syringe needle, and FIG. 6 is a cross-sectional view showing a method of using the conventional syringe needle. As shown in FIG. 5, the conventional syringe needle 31 has an opening 32 at the tip and is always open. Therefore, as shown in FIG. 6, the syringe needle is attached to the sample 19 having the upper phase 17 and the lower phase 18. When 31 is introduced, the component 17a of the upper phase enters the tip of the syringe needle 31, and only the component of the lower phase 18 cannot be extracted. Similarly, when the liquid is injected into the lower phase 18, the liquid or solid in the upper phase 17 may enter the syringe needle 31 and the injection liquid may leak into the liquid or solid in the upper phase 17. There is.

  Accordingly, an object of the present invention is to provide a syringe capable of injecting a component into the lower phase or extracting a component from the lower phase without being influenced by the upper phase even if a syringe needle is introduced into the phase-separated sample. It is to provide a method for using a needle and a syringe needle.

  As a result of intensive studies to solve the above problems, the present inventor has provided a predetermined opening / closing function to the syringe needle, so that the injection of the component into the phase or the component from the lower phase can be performed without being affected by the upper phase. It has been found that extraction can be performed, and the present invention has been completed.

That is, the syringe needle of the present invention is a syringe needle having a hollow cylindrical portion and a tip portion.
An opening / closing device is provided on the side surface of the cylindrical portion or the opening portion existing in the tip portion.

  In the syringe needle of the present invention, it is preferable that the tip portion has a shape in which the inner diameter of the cylindrical portion is gradually narrowed.

  In the syringe needle of the present invention, the opening / closing device is preferably an opening / closing valve.

  Preferably, the opening / closing device has an inner cylindrical body that is inserted from the cylindrical portion to the distal end portion, and the opening portion is opened and closed by taking in and out the inner cylindrical body. Good.

  Further preferably, the opening / closing device includes an inner cylinder that is rotatably inserted from the cylindrical portion to the tip and has an opening at a position overlapping the opening, and the opening of the inner cylinder The opening portion may be opened and closed by making the portion and the opening portion present on the side surface or the tip portion of the cylindrical portion coincide or disagree.

The method of using the syringe needle of the present invention introduces the syringe needle into a sample having an upper phase made of solid or liquid and a lower phase made of liquid under the upper phase,
In the lower phase, the syringe needle opening and closing device is opened and closed to inject the component into the lower phase or extract the component from the lower phase.

  According to the present invention, the above configuration allows the injection of the component into the lower phase or the introduction of the component from the lower phase without being affected by the upper phase even when the syringe needle is introduced into the phase-separated sample. It is possible to provide a syringe needle that can be extracted and a method of using the syringe needle.

It is explanatory drawing which shows an example of the syringe needle of this invention. It is explanatory drawing which shows another example of the syringe needle of this invention. It is explanatory drawing which shows an example of the usage method of the syringe needle of this invention. It is explanatory drawing which shows another example of the syringe needle of this invention. It is a perspective view which shows the conventional syringe needle. It is explanatory drawing which shows the usage method of the conventional syringe needle.

Hereinafter, preferred embodiments of the present invention will be described in detail.
The syringe needle of the present invention has a hollow cylindrical portion and a distal end portion, and has an opening / closing device on a side surface of the cylindrical portion or an opening existing in the distal end portion. By providing such an opening / closing device, it is possible to inject components into the lower phase or extract components from the lower phase without being affected by the upper phase even if the syringe needle is introduced into the phase-separated sample. it can.

  In the present invention, the sample may have a layer made of a solid or a liquid between the upper phase and the lower phase, or under the lower phase.

  Further, in the syringe needle of the present invention, it is preferable that the inner end of the cylindrical portion is gradually narrowed at the distal end, for example, it is conically thin (FIGS. 1 (c) and 1 (d)) or a blade shape. (FIGS. 1A and 1B).

  Although the switchgear according to the present invention is not particularly limited, the following preferred embodiments can be exemplified.

  FIGS. 1A and 1B are explanatory views showing a preferred example of the syringe needle of the present invention. The syringe needle 1 has a valve 2 at the opening of the tip 3, and the valve 2 is an opening / closing device. In FIG. 1A, the valve 2 is in a closed state. As shown in FIG. 1B, the valve 2 is movably attached at one end to the tip 3 and can be opened.

  FIGS. 1C and 1D are preferred examples in which the valve 2 is provided on the side surface of the cylindrical portion 4 of the syringe needle 1. The syringe needle 1 has a valve 2 at the opening on the side surface of the cylindrical portion 4, and the valve 2 is an opening / closing device. In FIG. 1C, the valve 2 is in a closed state. As shown in FIG. 1D, the valve 2 is movably attached to one side surface of the cylindrical portion 4 and can be opened. By using the valve 2 shown in FIG. 1 as the switchgear, even if the syringe needle is introduced into the phase-separated sample, the injection of the component into the lower phase or the introduction of the component from the lower phase is not affected by the upper phase. Extraction can be performed.

  FIG. 2 is an explanatory view showing another preferred example of the syringe needle of the present invention. As shown in FIG. 2A, the syringe needle 11 shown in the figure has an inner cylindrical body 12 into which the opening / closing device is inserted from the cylindrical portion to the distal end portion. The opening 14 is opened and closed by taking in and out the inner cylinder 12.

  Such an opening / closing device has a double structure of an inner cylindrical body 12 and a cylindrical portion 13 having an opening 14. The cylindrical portion 13 has a distal end portion 3 whose inner diameter is gradually narrowed. On the other hand, the inner cylinder 12 has a solid cylindrical portion and a tip portion in which the inner diameter of the cylindrical portion gradually decreases, and has a structure that is inserted from the cylindrical portion 13 to the tip portion 3. The opening 14 may be provided not at the cylindrical portion 13 but at the tip portion 3, and the inner cylinder 12 may be solid or hollow.

  With this structure, the opening 14 of the cylindrical portion 13 can be closed by the inner cylindrical body 12. Moreover, this syringe needle 11 can open the opening part 14 by pulling out the inner side cylinder 12 in the longitudinal direction (arrow) of FIG.2 (b).

  FIG. 3 is an explanatory view showing an example of a method of using the syringe needle 11 shown in FIG. As shown in FIG. 3A, first, the syringe needle 11 is introduced into a sample 19 having an upper phase 17 and a lower phase 18 with the opening 14 closed. Thereafter, as shown in FIG. 3 (b), when the syringe needle 11 is introduced to the lower phase 18, the inner cylinder 12 is pulled out to open the opening 14, and only the component of the lower phase 18 is removed from the cylindrical portion 13. It can be extracted into the hollow part (arrow A).

  FIG. 4 is an explanatory view showing still another preferred example of the syringe needle of the present invention. As shown in FIG. 4A, the illustrated syringe needle 21 includes an inner cylindrical body 22 having an opening 25 and a cylindrical portion 23 having an opening 24. In the syringe needle 21, the inner cylindrical body 22 is rotatably inserted from the cylindrical portion 23 to the tip, and an opening 25 exists at a position overlapping the opening 24. The opening 24 can be opened and closed by making the opening 25 of the inner cylinder 22 and the opening 24 present on the side surface of the cylinder 23 coincide or disagree.

  Specifically, the opening / closing device is closed when the opening 25 of the inner cylinder 22 and the opening 24 of the cylinder 23 do not overlap (see FIG. 4B). On the other hand, when the opening 25 of the inner cylinder 22 and the opening 24 of the cylindrical part 23 overlap, the opening / closing device is open. The opening / closing device can be easily opened and closed by rotating the inner cylinder 22.

  The magnitude | size of the syringe needle of this invention is not specifically limited, It can determine suitably according to a use. The material of the syringe needle is not particularly limited as long as it does not react with the components in the sample. For example, plastic, metal, etc. can be used as appropriate, and stainless steel can be preferably used.

Hereinafter, the present invention will be described in more detail with reference to examples.
(Examples 1-4)
As Examples 1 to 4, the syringe needles A1 and A2 of the type shown in FIGS. 1A and 1B, the syringe needle B of the type shown in FIGS. 1C and 1D, and the type shown in FIG. The syringe needle C and the syringe needle D of the type shown in FIG. 4 were each made of stainless steel.

(Comparative example)
On the other hand, as a comparative example, a conventional type syringe needle shown in FIG. 5 was made of stainless steel.

  Using the syringe needles of Examples 1 to 4 and Comparative Example, the components of the lower phase of the two-layered sample having the upper phase and the lower phase were extracted. In Examples 1 to 4, only the lower phase component was successfully extracted without including the upper phase component, whereas in the comparative example, the upper phase component was mixed, and only the lower phase component was included. Could not be extracted.

DESCRIPTION OF SYMBOLS 1, 11, 21 Syringe needle 2 Valve 3 Tip part 4, 13, 23 Cylindrical part 12, 22 Inner cylinder 14, 24 Opening part 17 Upper phase 17a Upper phase component 18 Lower phase 19 Sample 25 Opening part 31 Conventional syringe Needle 32 opening

Claims (6)

In a syringe needle having a hollow cylindrical portion and a tip portion,
A syringe needle having an opening / closing device in an opening portion present on a side surface of the cylindrical portion or the tip portion.   The syringe needle according to claim 1, wherein the tip portion has a shape in which the inner diameter of the cylindrical portion is gradually narrowed.   The syringe needle according to claim 1 or 2, wherein the opening / closing device is an open / close valve.   The syringe needle according to claim 1 or 2, wherein the opening / closing device has an inner cylindrical body that is inserted and fitted from the cylindrical portion to the distal end portion, and the opening portion is opened and closed by taking in and out the inner cylindrical body. .   The opening / closing device has an inner cylindrical body that is rotatably inserted from the cylindrical portion to the tip and has an opening at a position overlapping the opening, and the opening of the inner cylindrical body and the cylinder The syringe needle according to claim 1 or 2, wherein the opening is opened and closed by making the side surface of the portion or the opening existing at the tip end coincide or not. A syringe needle according to any one of claims 1 to 5 is introduced into a sample having an upper phase consisting of a solid or a liquid and a lower phase consisting of a liquid below the upper phase,
A method of using a syringe needle, wherein the syringe needle opening and closing device is opened and closed in the lower phase to inject a component into the lower phase or extract a component from the lower phase.

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