JP2010180190A - Deodorant - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a deodorant having excellent deodorizing/antibromic effects, persistence thereof, and a good feeling of use without stickiness. <P>SOLUTION: The deodorant includes a liposome containing an antioxidant of a liquid oil, and a trehalose. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a deodorant composition suitable for body deodorization and deodorization.

  With the recent increase in etiquette orientation, deodorant needs for body odor are increasing. Deodorant agents containing antioxidants have been proposed because of the oxidation of metabolites as a cause of body odor generation. However, when cosmetics containing antioxidants such as vitamin E are applied to the skin surface, the production of lipid peroxide derived from metabolites is suppressed and the deodorant effect is exhibited, but the effect is insufficient. Since it is a stable substance, the sustainability of the deodorant effect was also insufficient. Furthermore, there was a problem such as a sticky feeling caused by the antioxidant. In addition, metabolites that are sources of body odor exist not only in the skin surface but also in the stratum corneum. However, although the antioxidant acts on the skin surface, the deodorant effect and its sustainability are insufficient because the penetration into the skin is weak in the form as it is and the action inside the stratum corneum is weak.

JP 2007-63192 A Japanese Patent Laid-Open No. 11-286423

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a deodorant agent that has excellent deodorizing and deodorizing effects and its sustainability and is non-sticky and has a good feeling of use.

  As a result of intensive studies to achieve the above-mentioned object, the present inventors have found that, among a number of compounds, a combination of liposomes containing an antioxidant, which is a liquid oil, and trehalose can provide a remarkable deodorizing / deodorizing effect. It has been found that it exhibits its sustainability, is non-sticky and has a good feeling of use, and has led to the present invention.

Accordingly, the present invention provides the following deodorant agent.
[1]. A deodorant comprising a liposome containing a liquid oil antioxidant and trehalose.
[2]. The deodorant composition according to claim 1, wherein the liposome has an average particle diameter of 20 to 40 nm and is composed of a single layer film.
[3]. The deodorant composition according to [1] or [2], wherein the antioxidant is vitamin E and / or a derivative thereof.

  ADVANTAGE OF THE INVENTION According to this invention, while having the outstanding deodorizing and deodorizing effect and its sustainability, it can provide the deodorant agent which is not sticky and has a favorable usability.

Hereinafter, the present invention will be described in detail.
The deodorant agent of the present invention comprises a liposome containing an antioxidant, which is a liquid oil, and trehalose.

  Liposomes used in the present invention are those in which an antioxidant, which is a liquid oil, is coated with a lamellar or thin film liquid crystal film made of an amphiphilic substance such as phospholipid. Antioxidants for liquid oil include vitamin E and / or its derivatives D-α-tocopherol, DL-α-tocopherol, D-α-tocopherol acetate, DL-α-tocopherol acetate, vitamin A and / or its Examples of the derivatives of retinol, retinol ester, retinal, and retinoic acid include ascorbyl palmitate and β-carotene. Among these, D-α-tocopherol acetate has a higher antioxidant ability and is more preferable. The liquid oil here means oil that is liquid at normal temperature (15 to 25 ° C.).

  0.001-1 mass% is preferable with respect to a deodorant agent, and, as for the compounding quantity of an antioxidant, 0.04-0.1 mass% is more preferable. If the blending amount is less than 0.001% by mass, the effect of suppressing odor may not be sufficiently obtained, and if it exceeds 1% by mass, the sticky feeling may be deteriorated.

Although the magnitude | size of a liposome is not specifically limited, The average particle diameter of 150-250 nm is preferable and 20-40 nm is more preferable. The interval between human keratinocytes is about 50 nm. In order to improve the transdermal absorbability of the liposome and to improve the deodorizing effect due to the antioxidant action, the liposome smaller than 50 nm is preferable. The average particle diameter here means a diameter giving a height of 50% in a cumulative distribution diagram based on the number, and means a particle number median diameter. The average particle diameter can be obtained by the following measurement method.
Particle diameter measurement method: Number average particle diameter measurement method Apparatus: Light scattering photometer (ELS-8000 manufactured by Otsuka Electronics Co., Ltd.)
Measuring method: Dynamic light scattering (DLS)
Measurement conditions: measured at 25 ° C

  The constituent components of the liposome are not particularly limited, and include a liquid oil antioxidant, a nonionic surfactant, a phospholipid, an organic acid salt, and water. Moreover, a commercially available product can be used for the liposome, and examples of the commercially available product include liposome: Tinoderm E manufactured by Ciba Specialty Chemicals. Tinoderm E is DL-α-tocopherol acetate as an antioxidant of liquid oil, caprylic acid / capric acid triglyceride as other components, water, polyoxyethylene sorbitan monooleate (20E.O.), soybean phospholipid, It consists of disodium hydrogen phosphate, sodium hydrogen phosphate, and disodium edetate. TinodermE contains 2% D-α-tocopherol acetate.

  Trehalose used in the present invention is a non-reducing disaccharide in which two molecules of glucose are linked by 1,1. There are two types of isomers, α, α-type trehalose (α-D-glucopyranosyl α-D-glucopyranoside), α, β type (neotrehalose), and β, β type (isotrehalose). In the present invention, any type may be used, and one type may be used alone, or two or more types may be used in appropriate combination, and α and α types are particularly preferable. Moreover, a commercial item can be used for trehalose, and a commercial item includes trehalose (for cosmetics) (manufactured by Hayashibara Biochemical Laboratories Co., Ltd.).

  0.1-10 mass% is preferable with respect to the deodorant agent whole quantity, as for the compounding quantity of a trehalose, 1-5 mass% is more preferable, and 1-5 mass% is further more preferable. If the blending amount is less than 0.1% by mass, the effect of suppressing odor may not be sufficiently obtained, and if it exceeds 10% by mass, it may become sticky and feel unusable.

  In the deodorant agent, an antiperspirant component such as chlorohydroxyaluminum and zinc paraphenolsulfonate is preferably blended from the viewpoint of suppressing odor generated from the skin more effectively by suppressing the secretion of sweat and sebum. 0.1-30 mass% is preferable with respect to the deodorant agent whole quantity, and, as for the compounding quantity of an antiperspirant component, 0.3-25 mass% is more preferable. Within this range, the effect of suppressing the secretion of sweat and sebum can be further obtained, and if it exceeds 30% by mass, clogging may occur at the time of spraying or the blending amount of other blending components may be limited.

  Moreover, it is good to mix | blend bactericidal components, such as an isopropyl methylphenol and a benzalkonium chloride liquid, from the point which suppresses the odor which generate | occur | produces from skin more effectively by weakening the function of skin resident bacteria. The blending amount of the sterilizing component is preferably 0.01 to 5.0% by mass, and more preferably 0.05 to 1% by mass with respect to the total amount of the deodorant agent. Within this range, the bactericidal effect can be further obtained.

  In the deodorant agent of the present invention, optional components can be blended singly or in appropriate combination of two or more as long as the effects of the present invention are not impaired. Optional components include, for example, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, oils such as silicone oils and ester oils, inorganic powders, organic powders, polymers Compounds, moisturizers, clathrate compounds, vitamins, UV absorbers, amino acids, anti-inflammatory agents, cooling agents, antioxidants, colorants, fragrances, preservatives, solvents (ethanol etc.), fatty acids, water, etc. Is mentioned. In addition, a compounding quantity is selected suitably.

  The deodorant agent of the present invention can be made into a solid, semi-solid, gel, liquid, etc., specifically, powder spray, mist, sheet, stick, roll-on type, etc. Is preferred. Among these, in the case of powder spray, it can be obtained by blending a deodorant agent (raw solution) with a propellant such as liquefied petroleum gas (LPG) or dimethyl ether and filling the aerosol can. The mass ratio between the deodorant agent (stock solution) and the propellant is preferably in the range of deodorant agent (stock solution) / propellant = 1/99 to 20/80. In the case of powder spray, the propellant is not included in the total amount of deodorant in the amount of liposome and trehalose. In the case of forming a sheet, it can be obtained by impregnating a carrier such as a spunlace nonwoven fabric or a spunbond nonwoven fabric of an appropriate size with a trunk deodorant agent. The impregnation amount of the trunk deodorant agent is preferably 2 to 4 times (mass) of the carrier amount.

  Although it does not specifically limit as a usage method, By applying a deodorant agent to a trunk, the oil odor generated from a trunk can be deodorized and deodorized.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, unless otherwise specified, “%” in the composition represents mass%, and the amount of each component in the table is an amount converted into a pure component.

[Examples 1-5, Comparative Examples 1-3]
The mist type deodorant agents listed in Table 1 were prepared on the basis of conventional methods and evaluated as follows. The results are also shown in the table.

[Trunk deodorant effect]
Twenty male subjects (average age 31 years old) have a sample sprayed about 10 times (equivalent to 1 g of preparation) on the trunk after bathing, and then wear a test T-shirt that has been washed in advance. received. Have the T-shirts go to bed, collect the T-shirts the next day, and perform sensory evaluation on the odor adhering to the torso of the T-shirts based on the following evaluation criteria with 5 specialist panels. The average point of odor was determined. The average point of odor evaluation of 20 worn T-shirts was determined. A result is shown based on the following deodorant effect criteria. The subject prohibited the use of other antiperspirant deodorant agents from 3 days before the test, and was asked to use an unscented botisorap during bathing.
<Evaluation criteria>
5 points: Strong odor attached to the T-shirt 4 points: Strong odor attached to the T-shirt 3 points: The odor attached to the T-shirt can be easily detected 2 points: The odor attached to the T-shirt is known 1 point of weak odor: very weak odor that can finally be recognized by the odor attached to the T-shirt 0 point: almost no odor attached to the T-shirt
<Trunk Deodorant Effect Standard>
◎: Average score of odor evaluation is 0 or more and less than 1 mark ○: Average score of odor evaluation is 1 or more and less than 2 points △: Average score of odor evaluation is 2 or more and less than 3.5 points ×: Average of odor evaluation Points 3.5 or more and 5 or less

[Feel of use (no stickiness)]
Method (use feeling: no stickiness)
Twenty male subjects (average age 31 years old) have bathed and sprayed the sample to the trunk about 10 times (equivalent to 1 g of preparation), and performed sensory evaluation on the touch on the skin based on the following evaluation criteria. It was. A result is shown based on the following use feeling effect criteria from the sensory evaluation average value of 20 test subjects.
<Evaluation criteria>
5 points: very sticky 4 points: sticky 3 points: slightly sticky 2 points: hardly sticky 1 point: not sticky at all
<Usage feeling effect standard>
A: The average score of 20 subjects is 1 or more and less than 2 ○: The average score of 20 subjects is 2 or more and less than 3 Δ: The average score of 20 subjects is 3 or more and less than 4 points ×: 20 subjects The average score is 4 or more and 5 or less

(Note) Uses Tinoderm E. Tinoderm E contains 2% of DL-α-tocopherol acetate.

[Example 6]
Mist type deodorant agent The mist type deodorant agent of the following composition was prepared based on the conventional method.
Composition%
Trehalose 2.0
(Product name: Trehalose (for cosmetics), Hayashibara Biochemical Research Institute)
DL-α-tocopherol acetate 0.04

(Product name: Tinoderm E, Ciba Specialty Chemicals) Benzalkonium chloride 0.5
(Net)
(Product name: Trizone solution, Yamada Pharmaceutical Co., Ltd.)
Zinc paraphenol sulfonate 2.5
Ethanol 30.0
Purified water balance 100.0

[Example 7]
Powder Spray Type Deodorant Agent A powder spray type deodorant agent having the following composition was prepared based on a conventional method.
Composition%
<Undiluted solution>
Trehalose 3.0
(Product name: Trehalose (for cosmetics), Hayashibara Biochemical Research Institute)
DL-α-tocopherol acetate 0.05

(Product name: Tinoderm E, Ciba Specialty Chemicals) Isopropylmethylphenol 0.1
(Product name: Isopropylmethylphenol, Osaka Kasei Co., Ltd.)
Chlorhydroxyaluminum 23.0
Silicic anhydride 5.0
Isopropyl myristate 53.9
POE (20) glyceryl triisostearate 15.0
Total 100.0
<Propellant>
Liquefied petroleum gas (0.15 MPa, 20 ° C.) 100.0
<Stock solution / propellant ratio = 10/90>

Claims (3)

  A deodorant comprising a liposome containing a liquid oil antioxidant and trehalose.   The deodorant composition according to claim 1, wherein the liposome has an average particle diameter of 20 to 40 nm and is composed of a single layer film.   The deodorant composition according to claim 1 or 2, wherein the antioxidant is vitamin E and / or a derivative thereof.