JP2010143847A - Method for preserving hair for gene therapy of alopecia and hair preservation system - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To preserve healthy hair containing hairy root parts of a plurality of parts of the head in a shape retained state for each user for a long period of time simply and at a low cost without depending upon a specialist so as to perform a gene therapy of alopecia by using one's own hair in the future. <P>SOLUTION: Hair containing hairy roots of a plurality of parts of user is collected by using a hair preservation tray 20 having a hair feed groove 22 packed with a vitrifying liquid to which hair containing hairy root parts is fed in a shape retained state for each part of the head, sealing projected parts 26 at a lid part and holding the hair in the vitrifying liquid in a shape retained state when a lid is closed and collectively sealing the hair, storage racks 30 for storing the hair preservation trays for each user and a heat insulating container 40 for closing the storage racks in liquid nitrogen. Healthy hair is selected on the basis of an appearance state. The hair is fed to the hair feed groove of the hair preservation tray and the tray is closed. An individual discrimination label is pasted on the hair preservation tray, which is stored in the storage rack. The storage rack is fed to liquid nitrogen in the heat insulating preservation container and closed. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention collects user's hair before alopecia develops, and when alopecia occurs in the user in the future, gene therapy for alopecia can be performed using the collected own hair The present invention relates to a hair storage method and a hair storage system for storing collected user's hair over a long period of time.

Conventionally, many people suffer from alopecia, and various hair growth agents and hair nourishing agents that improve hair loss and thinning have been marketed, but no complete method has been developed to date to treat alopecia.
In recent years, with the development of genetic technology, regenerative medical technology for treating diseases by transplanting healthy tissues of their own has been developed. For this reason, the hair prior to the onset of alopecia is also stored for the hair, and when the alopecia develops in the future, a copy is generated from the stored hair, and this is applied to its own head. It is considered that regenerative treatment for treating alopecia by transplantation will be put to practical use in the future.
In recent years, human DNA (human genome) has been rapidly deciphered, and it has been aimed to develop a new gene therapy technique based on the human genome decipherment result. By analyzing gene information before and after the occurrence, a gene that causes alopecia is identified, and gene therapy for treating alopecia based on this gene may be put to practical use in the future.

  Against the backdrop of the development of such genetic technology, “Hairogenics” of San Francisco, USA, has started a hair bank business that preserves the hair of users for a long time. This hair bank business vacuum-packs the collected user's hair with a waterproof package and stores it in a temperature-controlled underground cooler. The initial cost is $ 49 and the annual storage fee is $ 10. A service for preserving hair is provided (see Non-Patent Document 1).

  However, since such a hair bank is for vacuum-packing the collected user's hair and storing it for a long period of time, when it is stored for a long period of time, the deterioration of the cells proceeds and the stored self-replicated hair is replicated. May be used for future hair removal treatment, such as generating hair and transplanting it to a hair removal part, or extracting gene information of each part of the stored own hair and performing gene therapy.

  In general, as a method of storing cells extracted from the human body for a long time so that genetic information can be used in the future, the cultured cells are immersed in a high concentration cryoprotective solution such as vitrification solution and frozen with liquid nitrogen. A storage method is known (see, for example, Patent Document 1).

  In addition, as a method for treating alopecia, a method for treating alopecia by collecting hair follicle tissue of the remaining part of the own hair and transplanting it into the hair loss part is known. Discloses a method for allowing hair loss treatment over a long period of time by culturing and cryopreserving the collected hair follicle tissue.

NewsNet5.com, “Beat Baldness By Storing Hair Strands”, Posted: 9:49 am EDT April 29, 2002, [Searched on December 1, 2008] Internet <URL: HYPERLINK "http://www.newsnet5.com /health/1423182/detail.html "http://www.newsnet5.com/health/1423182/detail.html> JP 2008-92801 A JP 2002-145701 A

  However, the cell cryopreservation method as disclosed in Patent Document 1 is a method in which tissue is fragmented and cultured and cryopreserved, and is not stored in a state in which the morphology of the tissue is retained. It cannot be applied to the purpose of generating duplicates of the same form by gene technology or extracting gene information of each part of the tissue to enable gene therapy.

  Moreover, the cryopreservation method of the hair follicle disclosed in Patent Document 2 is to preserve the own hair follicle tissue and transplant it to the hair removal part, and is common for the purpose of performing hair removal treatment. Since the object is a hair follicle tissue, and a surgical procedure is performed to extract it from the human body, it is necessary to perform it by an expert such as a doctor. Moreover, since only the hair follicle tissue is preserved, it is difficult to determine whether or not it is healthy from the extracted hair follicle tissue, and there is an unhealthy hair follicle tissue that cannot be used in the future. There is a risk of being saved. Furthermore, since the properties of the hair have different characteristics depending on the site of the head, it is desirable to store it for each extraction site. However, in order to freeze and store for each extraction site, it is necessary to repeat a complicated procedure, which requires a lot of storage. There were problems such as cost.

  Therefore, the purpose of the present invention is to maintain the form of healthy hair including the roots of multiple parts of the head in order to enable gene therapy for alopecia using own hair in the future. It is intended to provide a hair storage method and a hair storage system that can be stored for a long time for each user in a state, easily and at low cost without depending on an expert.

  The hair storage method of the present invention is an openable and closable chip-shaped tray for storing a user's hair before the onset of alopecia for each user. Having a plurality of hair insertion grooves into which the hair including the portion can be introduced in a state in which the shape is maintained, and the lid portion being elastically formed in a mountain shape to seal each of the plurality of hair insertion grooves A cryoprotective solution that prevents cells from being destroyed when the hair is frozen with liquid nitrogen is previously injected into the hair insertion groove, and the lid portion is attached to the main body portion. A hair storage tray in which, when closed, the hairs of the respective parts that have been put in are collectively held in the cryoprotective liquid and sealed, and a storage rack that stores a plurality of the hair storage trays for each user , Liquid nitrogen sealed in an insulated container In the method of storing hair using an insulated storage container for long-term storage of the stored user-specific hair storage tray by closing the storage rack by putting it in liquid nitrogen in the insulated container The step of separating and collecting the hair including the hair root part of the plurality of parts of the head before the onset of alopecia of the user and the plurality of parts collected by the step of collecting the hair Separating healthy hair from a plurality of parts selected by the step of selecting healthy hair based on the appearance mode including the outer shape from the hair and the step of selecting the hair into predetermined hair insertion grooves of the hair storage tray And the step of closing the hair storage tray into which the hair has been input by the step of inserting into the hair input groove, and the step of closing the hair storage tray, and the hair storage tray closed by the step of closing the hair storage tray. A step of affixing the personal identification label, a step of accommodating the hair storage tray affixed with the personal identification label in the step of affixing the personal identification label in the accommodation rack, and a step of accommodating the hair storage tray in the accommodation rack. And a process of closing the storage rack in which the storage rack is stored in liquid nitrogen in the heat insulating storage container.

According to this invention, the main body portion has a plurality of hair insertion grooves into which the hair including the hair root portion can be input in a state that maintains the form for each part of the head, and the lid portion has the hair insertion groove. The hair is stored in a hair storage groove using a hair storage tray that has been pre-injected with a cryoprotective solution, so the collected hair is stored in the hair. Simply put into the corresponding hair feeding groove of the tray and close the lid, the hair of each part put in is collectively sealed in the freeze protection liquid, and the hair storage tray in which the user's hair is sealed Is placed in a storage tray and poured into liquid nitrogen in a heat-insulated container, so that hair including the roots of multiple parts of the head can be treated in the future so that alopecia can be treated using its own hair. , Expert to store for a long time for each user, keeping the form It can be realized simply and at low cost regardless.
Further, according to the present invention, since the hair including the hair root portion of the user is stored, when gene therapy for alopecia is performed in the future, the genetic information regarding the beneficial growth factor contained in the hair root portion is obtained. It can be obtained from the hair and treated.
In addition, according to the present invention, since the hair of a plurality of parts of the user's head is separated and stored, when performing gene therapy for alopecia in the future, the difference in characteristics of the user's head according to the part Considering this point, it is possible to perform appropriate gene therapy.
Further, according to the present invention, since the user's hair is preserved while maintaining its form, when gene therapy for alopecia is performed in the future, a replica of the same form as healthy hair is generated and transplanted, or tissue It is possible to extract gene information of each part so that appropriate gene therapy can be performed.
In addition, according to the present invention, since it includes a step of selecting healthy hair from the collected hair based on the appearance including the outer shape, when performing gene therapy for alopecia in the future, the gene is generated by unhealthy hair. Treatment can be prevented from being performed. In this invention, since the hair containing a hair root part is extract | collected in the process of extract | collecting hair, healthy hair can be easily selected based on the external appearance aspect containing an external shape.

It is preferable that the plurality of parts include a frontal head, a back head, a left side head, a right side head, a crown, and a toothpick part.
The forehead, back of the head, left side of the head, right side of the head, the top of the head, and the toothpick part are characteristic parts that show different characteristics depending on the symptoms of alopecia. When gene therapy for alopecia is performed in the future, more appropriate gene therapy can be performed in consideration of the difference in the characteristics of each part of the user's head.

The step of selecting the hair includes a hair mounting table on which the collected hair is mounted, a microscope camera that images the hair mounted on the hair mounting table, and an image of the hair imaged by the microscope camera. It is preferably performed by a computer having an image processing function for selecting healthy hair by inputting and comparing the appearance of the input image of the hair with the appearance of healthy hair registered in advance.
Since the step of selecting the hair is to select healthy hair based on the appearance aspect including the outer shape of the collected hair, the appearance aspect of the image of the hair imaged with the microscope camera is registered in advance. It can be automatically performed by a computer having an image processing function for comparison with the appearance mode of sound hair, and sound hair can be selected more reliably.

  The hair storage system of the present invention is an openable and closable chip-shaped tray for storing the user's hair before the onset of alopecia for each user. Having a plurality of hair insertion grooves into which the hair including the portion can be introduced in a state in which the shape is maintained, and the lid portion being elastically formed in a mountain shape to seal each of the plurality of hair insertion grooves A cryoprotective solution that prevents cells from being destroyed when the hair is frozen with liquid nitrogen is previously injected into the hair insertion groove, and the lid portion is attached to the main body portion. A hair storage tray in which, when closed, the hairs of the respective parts that have been put in are collectively held in the cryoprotective liquid and sealed, and a storage rack that stores a plurality of the hair storage trays for each user , With liquid nitrogen sealed in an insulated container Then, by putting the storage rack into the liquid nitrogen in the heat insulation container and closing it, the heat storage container for storing the stored hair storage tray for each user for a long time, and the collected user's A hair mounting table for mounting hair, a microscope camera for imaging the hair mounted on the hair mounting table, and moving the microscope camera so that it can image all the hair mounted on the hair mounting table A hair selection table having a camera moving mechanism to be used, and a computer server for managing the storage state of the user's hair, and printing a personal identification label to be attached to the hair storage tray based on the input user information Personal identification label printing means, and personal identification label reading for reading and inputting personal identification information printed on the personal identification label affixed to the hair storage tray A hair storage management function for managing a storage position of each user's hair storage tray stored in the storage rack in the heat insulating storage container, and hair imaged by a microscope camera of the hair selection table A hair storage management server having an image processing function for selecting healthy hair by comparing the appearance of the input image of the hair with the appearance of the healthy hair registered in advance. It is a thing.

According to this invention, the main body portion has a plurality of hair insertion grooves into which the hair including the hair root portion can be input in a state that maintains the form for each part of the head, and the lid portion has the hair insertion groove. The hair is stored in a hair storage groove using a hair storage tray that has been pre-injected with a cryoprotective solution, so the collected hair is stored in the hair. Simply put into the corresponding hair feeding groove of the tray and close the lid, the hair of each part put in is collectively sealed in the freeze protection liquid, and the hair storage tray in which the user's hair is sealed Is placed in a storage tray and poured into liquid nitrogen in a heat-insulating container, so that hair including the hair roots of multiple parts of the head can be treated in the future with the use of own hair. , Expert to store for a long time for each user, keeping the form It can be realized simply and at low cost regardless.
In addition, according to the present invention, the hair storage management includes a personal identification label printing means for printing a personal identification label to be attached to the hair storage tray, and a personal identification label reading means for reading the personal identification label attached to the hair storage tray. Since the storage location of each user's hair storage tray stored in the storage rack is computer-controlled by the server's hair storage management function, each user's hair stored in the heat insulating storage container can be quickly and accurately stored. It can be taken out and used for alopecia gene therapy.
In addition, according to the present invention, a hair selection table for picking up the collected user's hair with a microscope camera is provided, and healthy hair can be automatically selected by the image processing function of the hair storage management server. The user's healthy hair to be selected can be selected more reliably.

  According to the present invention, in order to be able to perform gene therapy for alopecia using own hair in the future, in a state of maintaining the form of healthy hair including the hair root part of a plurality of parts of the head, There is an effect that long-term storage for each user can be performed easily and at a low cost without depending on an expert.

  The above object, other objects, features, and advantages of the present invention will become more apparent from the following description of the best mode for carrying out the invention with reference to the drawings.

FIG. 1 shows a system configuration of a hair storage system according to an embodiment of the present invention and a processing procedure of a hair storage method according to an embodiment of the present invention that uses this to store a user's hair.
A hair storage system according to an embodiment of the present invention includes a chip-shaped hair storage tray 20 for sealing a collected user's hair in a cryopreservation liquid, and a housing for storing the hair storage tray for each user. The rack 30, the hair storage tray stored in the storage rack can be put into liquid nitrogen, the heat insulating storage container 40 for freezing and storing the hair, and the collected user's hair can be used for gene therapy for alopecia A hair selection table 50 for selecting healthy hair and a hair storage management server 60 for managing the storage status of each user's hair storage tray stored in the heat insulating storage container 40 are provided.

FIG. 2 shows a schematic structure of a hair storage tray 20 that constitutes a hair storage system according to an embodiment of the present invention and is used in a hair storage method according to an embodiment of the present invention.
The hair storage tray 20 is an openable and closable chip-shaped sealed container for freezing and storing the collected user's hair in liquid nitrogen while maintaining the form, and has a main body portion and a lid portion.
2, (1) is a plan view when the lid portion of the hair storage tray is opened, (2) is a sectional view showing an AA cross section of the main body portion, and (3) is a BB cross section of the lid portion. It is sectional drawing shown.

  The main body of the hair storage tray 20 has a plurality of hair feeding grooves 22 for feeding hairs at a plurality of sites on the user's head, and the hairs are frozen with liquid nitrogen in each hair feeding groove. The vitrification solution 23 is preliminarily filled as a cryoprotective solution for preventing cells from being destroyed.

  In the present embodiment, six locations of the frontal head, the back of the head, the left side of the head, the right side of the head, the right side of the head, the top of the head, and the toothpick part having different hair characteristics are selected as the parts for storing the user's hair. The main body is provided with a hair feeding groove 22 corresponding to each storage site, and a storage site display 24 describing the hair storage site is attached to each hair feeding channel.

On the other hand, the lid portion of the hair storage tray 20 has an elastic sealing convex portion 26 formed in a mountain shape to seal each hair insertion groove 22 of the main body portion, and the lid portion is fixed to the main body portion. A lid closure 27 is provided.
Thereby, the collected hair of each part of the user is put into the corresponding hair feeding groove 22 of the main body part, and the use put in when the lid part is closed to the main body part and fixed by the lid closing tool 27. The hair of each part of the person is automatically sealed in the vitrification liquid in the hair feeding groove 22 for each storage part while maintaining the form.

A personal identification label 28 including a bar code for identifying the user of the hair storage tray is attached to the front surface of the hair storage tray 20 after the user's hair is sealed.
In addition, in this invention, attaching a personal identification label includes providing a label pocket in the front surface of the hair storage tray 20, and putting and displaying a personal identification label in this.

  FIG. 3 shows a schematic structure of a storage rack 30 according to an embodiment of the present invention. The storage rack 30 is a multi-stage storage shelf for storing the hair storage tray 20 for each user, and has a handle 32 for taking it out from the heat-insulating storage container 40 and carrying it.

The heat insulating storage container 40 includes a main body container formed of a heat insulating material and a heat insulating closing lid 46 for closing the main body container. The main body container is provided with a storage rack up-and-down mechanism 42 for setting the storage rack 30 and moving it up and down, and liquid nitrogen 44 is filled to a predetermined liquid level.
As a result, by lowering the storage rack 30 to the lowest point by the storage rack up-and-down mechanism 42, all the hair storage trays stored in the storage rack 30 are immersed in liquid nitrogen and insulated by the container closure 48. The hair storage tray 20 is frozen and stored in the adiabatic storage container 40 by fixing the lid 46 to the main body container.

  Since the liquid nitrogen 44 in the heat insulation storage container 40 is consumed by evaporation, it is necessary to replenish periodically so as to maintain a predetermined liquid level. The heat insulating storage container 40 has a pressure holding mechanism for holding the internal pressure below a certain level because the internal pressure rises due to the evaporation of liquid nitrogen in the closed state. To do.

  The storage rack up-and-down mechanism 42 moves the set storage rack 30 up and down step by step to store the newly stored user's hair storage tray 20 in the storage rack 30 or to store the user's hair storage tray that has already been stored. 20 can be taken out from the storage rack 30, but it may be a manual up-and-down mechanism with a ratchet mechanism that stops each storage rack at each level, according to a command from the hair storage management server 60. An electric vertical mechanism provided with a control means for controlling the receiving rack to a specified level may be used.

  The hair selection table 50 includes a hair mounting table 52 on which the hair collected from the user is mounted, a microscope camera 54 that images the hair mounted on the hair mounting table 52, and all the devices mounted on the hair mounting table 52. A camera moving mechanism 56 for moving the microscope camera 54 so that the hair of the hair can be imaged.

The hair storage management server 60 is a computer server in which a hair storage management program for managing the storage state of the user's hair is installed, and stores personal information of the user who receives the hair storage service and the hair storage tray of each user. A user information database in which places are registered is provided.
The hair storage management server 60 includes a label printer 62 for printing a personal identification label to be affixed to a newly stored hair storage tray, and a bar code for reading the personal identification label affixed to an existing hair storage tray The reader 64 is connected, and the personal identification label affixed to the hair storage tray strictly manages the withdrawal and insertion of each user's hair storage tray.

  The hair storage management server 60 includes an input / output interface connected to the hair selection table 50, drives the camera moving mechanism 56, moves the microscope camera 54, and each hair placed on the hair placing table. An image processing program for performing image processing for inputting healthy images and selecting healthy hair based on the appearance of the input hair image is installed.

Next, based on FIG. 1, the processing procedure of the hair preservation | save method which preserve | saves a user's hair with the said hair preservation | save system is demonstrated.
First, start the hair storage management program of the hair storage management server 60, select "User Registration" from the displayed menu screen, and enter the user name, contact information, etc., and the user information database Register user information in.

Next, the hair of the user before the onset of alopecia is collected by the hair collection tool 10.
There are 6 sites to be collected: frontal, occipital, left, right, top, and toothpick, which are considered to have the characteristic properties of the head, and have genetic information on hair growth factors. Collect the hair that contains the roots that are believed to be.

Hair is roughly divided into a hair shaft portion that appears on the surface of the skin and a hair root portion that is buried inside the skin, and a portion that swells in a spherical shape at the tip of the hair root portion is called a hair bulb.
As shown in FIG. 4, during the hair growth stage, the dermis enters the hair bulb at the tip of the hair root and is firmly fixed, and the hair matrix cells inside the hair bulb are connected to the capillary blood vessels of the subcutaneous tissue. It absorbs nutrients from the hair papilla and grows the hair. When the growth period is over, a regression phase occurs in which hair matrix cells are detached from the hair papilla. Then, the root sheath covering the hair root disappears and enters a resting period in which the fixing force of the hair is reduced, and then naturally depilates. Even after hair removal, if the hair papilla is healthy, new hair is generated and the above hair cycle is repeated.
As mentioned above, the hair is firmly fixed during the growth period, and if it is forcibly pulled, it may be cut off in the middle of the hair shaft or the subcutaneous tissue may be peeled off. It is preferable to carry out with respect to the hair from the regressing period to the resting period.

Next, the collected hairs are arranged on the hair mounting table 52 of the hair selection table 50, and “Select hair” is selected from the menu screen of the hair storage management server 60, whereby the hair imaged by the microscope camera 54 is selected. An image processing program for selecting healthy hair from an image is started.
In the image processing program, the microscope camera 54 is moved by the camera moving mechanism 56, the hair image captured by the microscope camera 54 is input for each hair mounted on the hair mounting table 52, and the appearance of the input hair image It is automatically determined whether or not each hair is healthy hair by comparing the appearance with the condition of appearance of healthy hair roots registered in advance, and each hair placed on the hair placing table 52 The determination result is displayed on the screen.

In FIG. 5, the example of the external appearance aspect of healthy hair and the external appearance aspect of unhealthy hair is shown.
(1) in FIG. 5 is an example of an appearance of healthy hair. The hair shaft has a predetermined range of length, a predetermined range of thickness, and a predetermined range of color corresponding to the hair pigment. The portion has a smooth elliptical outer shape, a maximum outer width of a predetermined range, an outer size of the predetermined range, and a predetermined range of colors corresponding to the pigment at the root of the hair.
On the other hand, (2) in FIG. 5 is an example of the appearance of unhealthy hair, A is an example of forcibly extracted hair, B, C, D, and E are examples of hair with thin hair and alopecia, and F is a circular shape. Examples of alopecia hair, GH are other examples of unhealthy hair. Each of A has an irregular hair root shape and a semi-transparent gelatinous tissue is attached around the hair root, B has almost no swelling of the hair root part, C has a deformed hair root part, and D There is a tail-like tip at the tip of the hair root, E has sebum attached to the hair root, F has a sharp hair root like a needle, and G has gray hair at the root of the hair shaft H is split off from the hair shaft to the root.

In the image processing program of the hair storage management server 60, as appearance mode conditions for selecting healthy hair, the length condition of the above-described healthy hair, the thickness condition of the hair shaft, the color condition of the hair shaft, The outer shape condition of the hair root part, the maximum outer width condition of the hair root part, and the color condition of the hair root part are registered in advance.
The image processing program of the hair storage management server 60 calculates the length of the hair shaft part, the thickness of the hair shaft part, the color of the hair shaft part, the outer shape of the hair root part, and the maximum outer shape of the hair root part from the inputted hair image of each part. Appearance aspect information regarding the width and color of the hair root is extracted, and these are compared with the above-described appearance aspect conditions registered in advance, and the hair determined to satisfy all the conditions is displayed as “good” For hair that is determined not to satisfy any of the conditions, a condition item that is determined not to be satisfied is presented, and a screen display that prompts the user to collect the hair at the site again is displayed.
In addition, you may make it register the hair image of each site | part finally selected as healthy hair as the said user's hair image data of a user information database.

  Next, healthy hair at each of the selected sites is charged into the vitrification solution 23 in the corresponding hair charging groove 22 of the hair storage tray 20.

  When all the selected hairs have been charged, the lid of the hair storage tray 20 is closed, and the lid is fixed to the main body by the lid closure tool 27. Thereby, the healthy hair of each part of the collected user is collectively sealed in the vitrification liquid of the hair storage tray while maintaining the form.

  Next, “print personal identification label” is selected from the menu screen of the hair storage management server 60, and the personal identification label 28 including the bar code display of the name, contact information, storage date, and personal identification number of the user. Is printed by the label printer 62, and the printed personal identification label is attached to the front surface of the hair storage tray 20.

Next, "Specify storage location of hair storage tray" is selected from the menu screen of the hair storage management server 60, and each accommodation in the heat insulation storage container is performed based on the storage location information of the user's hair storage tray from the user information database. Display the storage location of the rack in use. Then, the vacant accommodation position of the vacant accommodation rack is designated as the storage location of the user by the pointing device (mouse).
When the designation of the storage location of the hair storage tray is completed, the heat insulation closing cover 46 of the heat insulation storage container is opened, the designated storage rack is pulled up to the designated storage position, and the user's hair storage tray is moved to the corresponding storage rack. Store in the storage position.

When the storage of the hair storage tray in the storage rack is completed, the storage rack is pushed down to the lowest level, the heat insulation closing lid 46 of the heat insulation storage container 40 is closed, and the heat insulation closing lid 46 is fixed to the main body with the container closing tool 48. Thus, the storage of the user's hair storage tray in the heat insulating storage container is completed, and the user's hair is frozen and stored.
When the storage of the hair storage tray in the heat insulating storage container is completed, by selecting “Completion of storage of hair storage tray” from the menu screen of the hair storage management server 60, the user's hair storage tray is stored in the user information database. Save location and save start date are registered.

On the other hand, when the stored user's hair storage tray is used for gene therapy or the like, the hair storage management program of the hair storage management server 60 is started, and “Removal of Hair Storage Tray” is displayed from the displayed menu screen. ”And the user's name, date of storage, and the like are entered, and the storage location in the thermal storage container of the user's hair storage tray is displayed on the screen.
Then, the heat insulation closing cover 46 of the heat insulation storage container is opened, the storage tray displayed on the screen is pulled out to the displayed storage position, the hair storage tray is taken out, and the bar code reader 64 is attached to the front surface of the taken out hair storage tray. When the personal identification code is read and it is confirmed that it is the hair storage tray of the designated user, the storage position information of the user in the user information database is deleted by selecting “Extraction completion”. The date when the hair storage tray is taken out is registered as the extraction date information.

In the said embodiment, although demonstrated as what preserve | saved a hair preservation | save tray in a single heat insulation preservation | save container, it cannot be overemphasized that it may be made to divide | save into several heat insulation preservation | save containers as needed.
In addition, the insulated storage container described here is a temporary storage container in the place where the user's hair is collected, and the hair stored in the temporary storage container is provided with a separate storage room in which the hair storage tray can be stored frozen. The storage tray may be appropriately transferred.

  The heat insulating storage container 40 exemplified in the above embodiment shows the concept of immersing the hair storage tray 20 in liquid nitrogen to freeze and store the hair, and the evaporation of liquid nitrogen accompanying the removal and insertion of the hair storage tray 20 is shown. Although description of the means for minimizing is omitted, for example, an opening / closing mechanism that opens and closes only the portion of the storage rack for taking in and out of the hair storage tray may be provided. There may be provided a transfer mechanism for transferring the hair storage tray between the opening and closing opening and the opening and closing opening, the designated position of the storage rack in the heat insulating storage container, and the opening and closing opening.

In the above embodiment, the image processing for selecting healthy hair is described as being performed by comparing the appearance mode information extracted from the hair image with the pre-registered conditions for the appearance of healthy hair. As a condition of appearance of healthy hair, a representative image of healthy hair is registered as an image for determination, and the hair image captured by the microscope camera is matched with the image for determination to perform healthy hair You may make it determine whether it is.
In addition, a representative unhealthy hair image is registered as a judgment image together with a healthy hair image, and if it is judged unhealthy by image matching with a healthy hair judgment image, It is also possible to perform image matching with an image for determining correct hair to determine the type of unhealthy hair and display it on the screen.

  In the above embodiment, the hair of each part of the collected head is placed on the hair placing table, and the hair determined to be healthy hair by image processing is urged to collect the hair of the part again As described above, a plurality of hairs are collected for each part of the head and placed on the hair mounting table, the determination result for each hair is displayed on the screen, and the hair determined to be healthy is used for storage It may be.

  In the above embodiment, the hair selection is described as being automatically performed by the image processing function of the hair storage management server. However, the image of the microscope camera is displayed on the screen, and the appearance of the hair displayed on the screen is displayed by a person. You may make it select the hair which looks healthy.

  In the above-described embodiment, it has been described that one hair storage management server executes both the hair storage management function and the hair image determination function, but it goes without saying that each may be executed by a dedicated server. .

  In the above embodiment, the personal identification label includes a barcode for identifying the user and is read by the barcode reader connected to the hair storage management server. Needless to say, the character information printed on the personal identification label may be directly read using the OCR.

  In the above embodiment, the head part for storing the hair is the six parts of the frontal head, the back of the head, the left side of the head, the right side of the head, the top of the head, and the toothpick part that are considered to have characteristic properties. Some of these parts may be omitted, and other parts such as left and right hairline parts may be included.

As described above, according to the present invention, in order to enable gene therapy for alopecia using own hair in the future, a healthy hair including a hair root portion of a plurality of parts of the head is formed. A hair storage method and a hair storage system are provided that can be stored for a long time for each user in a state in which the hair is held, without relying on a specialist, at a low cost.
The invention of the present application is not limited to the above-described embodiment. As long as the effects of the invention of the present application are obtained, the constituent elements described in the embodiment are appropriately replaced, new constituent elements are added, or some configurations are configured. It goes without saying that elements may be deleted.

It is a conceptual block diagram which shows the processing sequence of the system configuration | structure of the hair preservation | save system which concerns on one Embodiment of this invention, and the hair preservation | save method which concerns on one Embodiment of this invention which preserve | saves a user's hair using this. It is an illustration figure of the hair preservation | save tray which concerns on one Embodiment of this invention. It is an illustration figure of the accommodation rack which concerns on one Embodiment of this invention. It is explanatory drawing explaining the growth cycle of hair. It is a figure which shows the example of the external appearance aspect of the hair for selecting healthy hair.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Hair sampling device 20 Hair storage tray 22 Hair insertion groove 23 Vitrification liquid 24 Storage part display 26 Convex convex part 28 Personal identification label 30 Storage rack 40 Thermal insulation storage container 42 Storage rack vertical mechanism 44 Liquid nitrogen 50 Hair selection table 52 Hair Mounting table 54 Microscope camera 56 Camera moving mechanism 60 Hair storage management server 62 Label printer 64 Bar code reader

Claims (4)

An openable and closable chip-shaped tray for storing the user's hair before the onset of alopecia according to the user, and the body part has a hair shape including a hair root part for each part of the head. The lid has a plurality of hair insertion grooves that can be inserted in a held state, and the lid has elastic sealing projections formed in a mountain shape to seal each of the plurality of hair insertion grooves. And a cryoprotective solution that prevents cells from being destroyed when the hair is frozen with liquid nitrogen is injected into the hair insertion groove, and is introduced when the lid portion is closed to the main body portion. A hair storage tray in which the hair of each part is collectively sealed in the cryoprotective liquid,
A storage rack for storing a plurality of the hair storage trays for each user;
Liquid nitrogen is sealed in a heat insulating container, and the stored rack for each user is stored for a long time by closing the storage rack by putting the storage rack into the liquid nitrogen in the heat insulating container. An insulated storage container,
A method of storing hair using
A step of separating and collecting hair including a hair root part of a plurality of parts of the head before the onset of alopecia of the user,
Selecting healthy hair based on an appearance aspect including an outer shape from hair of a plurality of sites collected by the step of collecting the hair;
A step of separating a plurality of hairs selected by the step of selecting the hair into a predetermined hair input groove of the hair storage tray,
The step of closing the hair storage tray into which the hair has been introduced by the step of introducing into the hair introduction groove;
Applying a personal identification label for identifying a user to the hair storage tray closed by the step of closing the hair storage tray;
Storing the hair storage tray on which the personal identification label is pasted by the step of pasting the personal identification label in the housing rack;
Charging and closing the storage rack in which the hair storage tray is stored in the storage rack into the liquid nitrogen in the heat insulation storage container; and
A method for preserving hair, comprising:   The hair storage method according to claim 1, wherein the plurality of parts include a forehead, a back of the head, a left side of the head, a right side of the head, a top of the head, and a toothpick part.   The step of selecting the hair includes a hair mounting table on which the collected hair is mounted, a microscope camera that images the hair mounted on the hair mounting table, and an image of the hair imaged by the microscope camera. The input is performed by a computer having an image processing function for selecting healthy hair by comparing the appearance of the image of the input hair with the appearance of healthy hair registered in advance. The hair preservation method according to claim 1 or claim 2. An openable and closable chip-shaped tray for storing the user's hair before the onset of alopecia according to the user, and the body part has a hair shape including a hair root part for each part of the head. The lid has a plurality of hair insertion grooves that can be inserted in a held state, and the lid has elastic sealing projections formed in a mountain shape to seal each of the plurality of hair insertion grooves. And a cryoprotective solution that prevents cells from being destroyed when the hair is frozen with liquid nitrogen is injected into the hair insertion groove, and is introduced when the lid portion is closed to the main body portion. A hair storage tray in which the hair of each part is collectively sealed in the cryoprotective liquid,
A storage rack for storing a plurality of the hair storage trays for each user;
Liquid nitrogen is sealed in a heat insulating container, and the stored rack for each user is stored for a long time by closing the storage rack by putting the storage rack into the liquid nitrogen in the heat insulating container. An insulated storage container,
About the hair mounting table on which the collected user's hair is mounted, the microscope camera that images the hair mounted on the hair mounting table, and all the hairs on which the microscope camera is mounted on the hair mounting table A hair selection table having a camera moving mechanism for moving so as to be imaged;
A computer server for managing the storage status of the user's hair, and printing means for printing a personal identification label to be applied to the hair storage tray based on the input user information; and affixed to the hair storage tray A personal identification label reading means for reading and inputting personal identification information printed on the personal identification label, and a storage position of each user's hair storage tray stored in the storage rack in the heat insulating storage container The hair storage management function for managing the hair and the hair image captured by the microscope camera of the hair selection table are input, and the appearance of the input hair image is compared with the pre-registered healthy hair appearance A hair storage management server having an image processing function for selecting healthy hair,
A hair storage system comprising: