JP2010132618A - Preparation for external use, sheet preparation for external use, and sheet preparation set for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a preparation for external use, a sheet preparation for external use and a sheet preparation set for external use which efficiently and continuously generate hydrogen at lower cost. <P>SOLUTION: The preparation for external use includes a hydrogen storage porous material, an organic acid, and an anhydrous thickener. The viscosity of the thickener is 20-30 mm<SP>2</SP>/S. The sheet preparation for external use is obtained by applying the preparation for external use on a sheet having a self-adhesive on one side. The sheet preparation set for external use is composed of the sheet having a self-adhesive on one side and the preparation for external use. Preferably, the anhydrous thickener is polyethylene glycol. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an external preparation, an external sheet preparation, and an external sheet preparation set, and more particularly, an external preparation with good stability, an external sheet preparation, and an external sheet preparation capable of generating hydrogen efficiently and continuously at a lower cost. Regarding the set.

  In recent years, people who are suffering from rheumatoid arthralgia, back pain, hay fever, general fatigue, cold, etc. due to aging or increased stress due to workplace automation, including diversification of nature and living environment, It is increasing regardless of.

  Therefore, various measures have been taken including medical institutions, and one of them is a method using negative ions. For example, Patent Document 1 discloses that a negative adhesive is generated in the adhesive layer of an outer skin adhesive type patch in which a hydrophilic adhesive layer containing moisture is laminated on one side of a film-like or sheet-like support. An external patch containing a body is disclosed. Patent Document 2 discloses a negative ion generator containing a negative ion generator and a hygroscopic body as essential components.

On the other hand, the hydrogen occluded in the hydrogen-absorbing porous material is quickly taken into the cells that make up the human body when directly taken into the body as eaten hydrogen, and produces ATP via the citric acid circuit in the mitochondria. In addition to promoting hydrogen, hydrogen is released and active oxygen such as hydroxy radicals and superoxide radicals are eliminated as water. It is known that this causes a physiological response to activate cells, and Patent Document 3 discloses that coral calcium powder is kneaded by adding water to 55% by weight and 45% by weight of flour. After being formed into a plate and dried, the dried molded body was oxidized and fired at 700 ° C. for 4 hours, and then reduced and fired at 650 ° C. for 4 hours in a reducing furnace in an N ₂ gas / H ₂ gas atmosphere. A method for producing edible hydrogen in a fine powder is disclosed. Patent Document 4 discloses an antioxidant composition obtained by mixing brown rice powder and calcined calcium calcium powder adsorbed with hydrogen.
JP 2003-171265 A JP 2003-169852 A JP 2005-245265 A JP 2007-217351 A

  However, although the method described in Patent Document 1 can reduce the influence due to the change in the amount of moisture in the air, since the negative ion generator is contained in the adhesive layer containing moisture, it has already been stored. Negative ions are generated, and sufficient negative ions cannot be generated during use, and it has been desired to generate negative ions and the like efficiently and continuously. In addition, although the method described in Patent Document 2 can reduce the influence due to the change in the amount of moisture in the air, it requires a hygroscopic body, which is costly and labor intensive, and negative ions and the like can be produced at a lower cost. There has been a demand for an external preparation and an external sheet having good stability that can be generated efficiently and continuously.

  In addition, since the methods described in Patent Documents 3 and 4 are mainly related to foods, there is room for improvement with regard to providing hydrogen to the skin efficiently and continuously as an external preparation.

  Accordingly, an object of the present invention is to solve the above-mentioned problems of the prior art, and to provide a highly stable external preparation, an external sheet preparation, and an external sheet preparation set that can generate hydrogen efficiently and continuously at a lower cost. It is to provide.

  As a result of intensive studies to solve the above problems, the present inventor uses an anhydrous thickener having a specific viscosity without coexisting a sheet having an adhesive and a hydrogen storage porous material during storage. Thus, the inventors have found that the above object can be achieved, and have completed the present invention.

That is, the external preparation of the present invention contains a hydrogen storage porous material, an organic acid, and an anhydrous thickener,
The anhydrous thickener has a viscosity of 20 to 30 mm ² / S.

  In the external preparation of the present invention, the hydrogen storage porous material is composed of hydrogen storage calcined coral calcium, hydrogen storage zeolite, hydrogen storage charcoal, hydrogen storage activated carbon, hydrogen storage barley stone, hydrogen storage tourmaline, and hydrogen storage rare earth ore. It is preferable that it is 1 or more types selected from the group, and it is preferable that the said anhydrous thickener is polyethyleneglycol. Further, the organic acid is preferably at least one selected from the group consisting of citric acid, tartaric acid, lactic acid, glycolic acid, malic acid, dilute hydrochloric acid, acetic acid, oxalic acid, and D-glucuronic acid, It is preferable to contain.

  The external sheet of the present invention is characterized in that the external preparation is applied to a sheet having an adhesive on one side.

  The external sheet preparation of the present invention is preferably formed by filling the external preparation into a push-type bottle, discharging the external preparation, and applying it to the sheet.

  The external sheet agent set of the present invention comprises a sheet having an adhesive on one side and the external agent.

  Moreover, it is preferable that the external sheet agent set of this invention consists of a push-type bottle filled with the said sheet | seat and the said external preparation.

  According to the present invention, it is possible to provide a highly stable external preparation, an external sheet preparation, and an external sheet preparation set that can efficiently and continuously generate hydrogen at a lower cost.

The external preparation of the present invention contains a hydrogen storage porous material, an organic acid, and an anhydrous thickener, and the anhydrous thickener has a viscosity of 20 to 30 mm ² / S, Specifically, a hydrogen storage porous material and an organic acid are added and mixed in an anhydrous thickener. By adopting such a configuration, the external preparation containing a hydrogen storage porous material does not come into contact with water before being applied to the skin, so at a lower cost, a large amount of hydrogen is immediately generated after the addition of water, In addition, since hydrogen is very little generated until water is added, hydrogen can be generated for a long time. Further, since a hydrogen storage porous material, an organic acid and an anhydrous thickener are mixed in advance, the stability is good and it can be used easily.

  The hydrogen storage porous material used in the present invention is not limited as long as it is porous and can store hydrogen, and the desired effect can be obtained. For example, hydrogen storage calcined coral calcium, hydrogen storage zeolite, hydrogen storage It is preferably at least one selected from the group consisting of charcoal, hydrogen storage activated carbon, hydrogen storage barleystone, hydrogen storage tourmaline and hydrogen storage rare earth ore, more preferably hydrogen storage calcined coral calcium or hydrogen storage zeolite. .

As a method for producing such a hydrogen storage porous material, for example, there is a production method described in JP-A-2005-245265, and specifically, the porous material is oxidized and fired in an oxidation firing furnace at 700 ° C. for 4 hours. Then, after returning to room temperature, two-step firing such as oxidation firing and reduction firing is performed such as reduction firing at a temperature of 650 ° C. for 4 hours in an atmosphere of N ₂ gas: H ₂ gas (90 vol.%: 10 vol.%). Can be manufactured.

  In addition, coral calcium used as a porous material is calcium contained in sandy fossil corals deposited on the sea floor, and fossil corals are rich in minerals such as magnesium and potassium in addition to calcium. Moreover, it is a natural material that is highly water-soluble and easily ionized, and therefore has high absorption efficiency into the human body. Such coral calcium is not particularly limited as long as the desired effect of the present invention can be obtained.

  Furthermore, zeolite used as a porous material is an aluminosilicate with fine pores in the crystal, and natural or synthetic products produced from crystal cavities formed in volcanic rocks and lava in hot spring areas are used. be able to. Zeolite has a bonded structure formed by silicon and aluminum mediating oxygen, and can store hydrogen in the pores by molecular adsorption.

  Furthermore, charcoal, activated carbon, barley stone, tourmaline and rare earth ore used as porous materials can use charcoal, activated carbon, barley stone, tourmaline and rare earth ore available on the market and occlude hydrogen. Thus, a hydrogen storage porous material can be obtained.

  In the present invention, the dosage form of the hydrogen storage porous material is not particularly limited as long as it can be added to an external preparation, and liquid, sol or gel fluid (for example, paste), powder, granule, tablet, etc. Can take form. In addition, other components may be added to the hydrogen occlusion porous material so long as the effects of the present invention are not impaired. For example, brown rice flour, soy milk, okara soy bean juice, etc. It can also be in the form of a paste. As the paste-like hydrogen storage porous material, for example, Sante Care (fucoidan paste, manufactured by Sante Global Co., Ltd.) can be used.

  Furthermore, the external preparation of the present invention contains an organic acid. By adding water just before being applied to the skin, the organic acid dissolves the hydrogen-absorbing porous material, so that a large amount of hydrogen is generated immediately and hydrogen is generated until water is added. Since it is small, hydrogen can be generated for a long time. The organic acid is not limited as long as it reacts with the hydrogen-absorbing porous material to generate hydrogen, but preferably citric acid, tartaric acid, lactic acid, glycolic acid, malic acid, dilute hydrochloric acid (for example, hydrochloric acid) Somonade), acetic acid (for example, cereal vinegar), oxalic acid and D-glucuronic acid, and more preferably citric acid that is easily available. The organic acid preferably does not contain water, and when it is liquid, it is preferably removed by evaporating water.

The external preparation of the present invention contains an anhydrous thickener. By dispersing the hydrogen storage porous material and the organic acid in a thickener that does not contain water, generation of hydrogen can be prevented and the dosage form can be stably maintained. Moreover, the viscosity of an anhydrous thickener is 20-30 mm < ² > / S. If the viscosity of the anhydrous thickener is less than 20 mm ² / S, the viscosity is too low and the hydrogen storage porous material and the organic acid precipitate, which is not preferable. On the other hand, when the viscosity of the anhydrous thickener exceeds 30 mm ² / S, it does not contain water, so it becomes nearly solid and cannot be applied. In addition, “anhydrous” of the anhydrous thickener is a concept including not only the case where water is not completely contained, but also the case where the lower limit amount of water that can prevent the generation of hydrogen is included, for example, 0.001% or less Of water.

  The anhydrous thickener that can be used in the present invention is not limited as long as it does not react with the hydrogen-absorbing porous material and the organic acid and can be dispersed well, but polyethylene glycol is preferable. Such polyethylene glycol is known as Japanese Pharmacopoeia Macrogol, and commercially available products such as PEG # 400, PEG # 600, PEG # 2000, PEG # 4000 (manufactured by NOF Corporation) and the like can be used. .

As the polyethylene glycol, may be alone viscosity using what is 20 to 30 mm ² / S, different viscosities in combination of two or more polyethylene glycols of viscosity and using the 20 to 30 mm ² / S May be. For example, PEG # 400 and PEG # 4000 can be mixed and used at a ratio of 10: 3 to 5: 2.

Furthermore, the external preparation of the present invention preferably contains a stirring sphere. By stirring with a stirring sphere, the dispersion state of the hydrogen storage porous material and the organic acid can be improved. Even when the hydrogen storage porous material and the organic acid are precipitated, the anhydrous thickener has a viscosity of 20 to 30 mm ² / S, so that it can be redispersed.

  The stirring sphere is not limited as long as it does not react with a hydrogen storage porous material, an organic acid, an anhydrous thickener, and the like, and the effects of the present invention can be obtained. For example, stainless steel, ceramic, Teflon ( A stirring ball made of (registered trademark) can be used. Further, only the surface may be made of stainless steel, ceramic, or Teflon (registered trademark). Furthermore, although the magnitude | size of a stirring ball is not limited, For example, the thing of diameter 1-50mm, especially 5-25mm can be sufficiently stirred, and is preferable.

  In the present invention, the mixing ratio of the hydrogen storage porous material and the organic acid is preferably 5: 1 to 5: 3, and more preferably 5: 1 to 5: 2. It is preferable that the mixing ratio of the hydrogen storage porous material and the organic acid is 5: 1 to 5: 3 because a more appropriate amount of hydrogen can be generated for a long period of time.

  Furthermore, the external preparation of the present invention may contain other components as long as the effects of the present invention are not impaired.

  The external sheet of the present invention is characterized in that the external preparation of the present invention is applied to a sheet having an adhesive on one side. Immediately before being attached to the skin, the external preparation of the present invention is applied onto the sheet and water is added, so that the stability becomes better.

  In the present invention, "application" is to have a form having the external preparation of the present invention on a sheet, and the application method is not particularly limited as long as the desired effect of the present invention is obtained. The external preparation of the present invention can be filled in a push-type bottle, and the external preparation can be discharged from the push-type bottle and applied to the sheet.

  The sheet that can be used in the present invention is not particularly limited as long as the desired effect of the present invention can be obtained. Preferably, the sheet is flexible and does not impair the feeling of use as a sheet for external use. A sheet formed of natural fibers and / or artificial fibers or a sheet formed of a polymer material can be appropriately selected and used. Furthermore, these materials may be used alone, or may be used as a sheet-like laminate in which at least two kinds selected from these materials are laminated.

  As a sheet | seat which consists of the said natural fiber and / or man-made fiber, paper, cloth, a towel, a blanket, knitting, a quilt, a nonwoven fabric, a woven fabric etc. can be mentioned, for example.

  Examples of the natural fibers include cotton, kapok, flax, ramie, cannabis, jute, shiro, manila hemp, sisal hemp, coyer fiber, etc., plant silk, rabbit silk, silk silk, wool (sheep), cashmere hair, Examples include animal fibers such as camel hair, alpaca hair, mohair, and eyelashes.

  Examples of the artificial fibers include, for example, recycled fibers such as artificial silk, sufu, viscose, and bemberg, or polyamide fibers, polyester fibers, polyacrylic fibers, polyvinyl alcohol fibers, polyalkylene paraoxybenzoate fibers, Examples thereof include synthetic fibers such as polyurethane fibers, polyvinylidene chloride fibers, polyvinyl chloride fibers, polyacrylonitrile fibers, polyethylene fibers, polypropylene fibers, and polyclar, or semi-synthetic fibers such as acetate artificial fibers.

  Examples of the sheet made of the polymer material include polyethylene, polypropylene, polyamide, polyester, polyurethane, ethylene-vinyl acetate copolymer, polyvinyl chloride, polybutadiene, cellophane, polychloroprene, polyamino acid, and nitrile rubber. It is possible to use a sheet in which a synthetic resin such as butyl rubber or silicone rubber or a synthetic rubber or the like is thinly formed, and if necessary, a foam (breathable) or non-breathable (non-breathable) foamed foam. Can also be used. In this case, in the case of non-breathable (non-breathable) sheets or foams, breathability (moisture permeability) is imparted by perforating or stretching in a range that does not allow the generated hydrogen to diffuse to the outside. You can also

  Further, the size and shape of the sheet are not limited as long as the desired effect of the present invention can be obtained, and can be appropriately determined according to the site to be used. For example, 6.5 cm × 4.2 cm, 9 A rectangular shape of 0.0 cm × 6.0 cm, 13.0 cm × 7.2 cm, or a circular shape having a diameter of 22 mm can be used. Moreover, as thickness of this sheet | seat, Preferably it is 15-250 micrometers, More preferably, it is 30-100 micrometers.

  The pressure-sensitive adhesive that can be used in the present invention is not particularly limited as long as the desired effect of the present invention can be obtained without reacting with the external preparation of the present invention, and can be attached to an appropriate part of the human body. Such an adhesive only needs to be provided on one side of the sheet, and may be provided on a part or the entire surface of the sheet, and is generally formed as an adhesive layer. Further, such an adhesive preferably has an adhesive strength that does not peel naturally during use, and preferably does not easily lose adhesiveness even when it comes into contact with moisture due to sweating, etc. Is a known lipophilic pressure-sensitive adhesive.

  Specific examples of the pressure-sensitive adhesive include a vinyl acetate pressure-sensitive adhesive, an acrylic pressure-sensitive adhesive, a polyvinyl alcohol-based pressure-sensitive adhesive, a polyvinyl acetal-based pressure-sensitive adhesive, a vinyl chloride-based pressure-sensitive adhesive, a polyamide-based pressure-sensitive adhesive, and a polyethylene-based pressure-sensitive adhesive. A thermoplastic adhesive such as an adhesive or a cellulose adhesive, or a rubber adhesive such as a nitrile rubber adhesive, a butyl rubber adhesive, or a chloroprene adhesive is preferably used. Is not particularly limited, but is preferably about 10 to 70 μm.

  To the external sheet of the present invention, a tackifier, an inorganic filler, an anti-aging agent, an antioxidant, an ultraviolet absorber, and a pigment are generally added to the pressure-sensitive adhesive within a range that does not impair the effects of the present invention. Etc. can be added.

  In the present invention, the push-type bottle is not limited as long as it does not react with a hydrogen storage porous material, organic acid, anhydrous thickener, etc. and can discharge the external preparation of the present invention, and is usually used in the cosmetics / pharmaceutical industry. Can be used.

  The external sheet preparation set of the present invention comprises a sheet having an adhesive on one side and the external preparation of the present invention. Moreover, it is preferable to consist of a push-type bottle filled with the sheet | seat and the external preparation of this invention. By setting it as an external sheet agent set like these, the external sheet agent of this invention can be obtained more easily.

FIG. 1 is a view showing an embodiment of the external preparation of the present invention. The push-type bottle (airless pump) 3 contains an external preparation 1 and a stirring ball 2. The external preparation 1 contains a hydrogen storage porous material, an organic acid, and an anhydrous thickener, and the anhydrous thickener has a viscosity of 20 to 30 mm ² / S. After the external preparation 1 is uniformly dispersed by the stirring balls 2, the external preparation 1 is discharged from the push bottle 3 in the direction of the arrow 4 and used. The external preparation 1 discharged from the push-type bottle 3 can be directly applied to the skin and water can be added to generate hydrogen for use.

  FIG. 2 is a view showing an embodiment of the external preparation sheet of the present invention. On the sheet 5 having the adhesive 6 on one side, the external preparation 1 is discharged from the push bottle 3 and applied, and then water is added to adhere the external sheet 7 to the skin (FIG. 3). By using the external preparation 1 and the external sheet 7 as described above, the effect of the present invention by the hydrogen storage porous material and the organic acid can be realized, and it is oxidized by active oxygen by being attached to pain, an inflammatory site, etc. Hydrogen can permeate into the cells over time, and inflammation can be suppressed by its reducing power, and an unprecedented immediate anti-inflammatory and analgesic action can be expected.

Next, this invention is demonstrated based on an Example.
Example 1
(Confirmation of the effects of water)
In order to confirm the influence by water, the oxidation-reduction potential (ORP) was measured using the oxidation-reduction potentiometer. The following materials A and B were used as measurement samples. The results are shown in Table 1.
Material A: 0.7 g of hydrogen storage porous material was added to 4.0 mL of PEG # 400 to make a total of 5.0 mL.
Material B: 0.7 g of hydrogen storage porous material was added to 4.0 mL of PEG # 400, and 1 mL of water was further added to make a total of 6.0 mL.
In addition, as a hydrogen storage porous material in Examples 1 to 4, hydrogen (trade name: manufactured by Sante Corporation) was used every day.

  The ORP of material A was 100 mV or higher, while the ORP of material B showed −75 mV after 5 minutes. From this result, it was shown that by adding water, hydrogen is generated and stability is deteriorated.

Example 2
Polyethylene glycol is used as an anhydrous thickener, mixed with 7.0 g of hydrogen storage porous material and 2.0 g of organic acid (citric acid) at the blending ratio shown in Table 2 below, the appearance is observed, and stability is further improved. Evaluation was made in two stages (◯, ×). In Table 2, # 400 indicates PEG # 400, and # 4000 indicates PEG # 4000.

When the mixing ratio of # 400 and # 4000 where the viscosity of the anhydrous thickener is in the range of ²⁰ to 30 mm ² / S is 10: 3 and 5: 2, it is gel-like and exhibits good stability and is simple It was an external preparation that can be used for On the other hand, when the mixing ratio was 10: 1, 5: 1, and 2: 1, the dispersion stability was poor.

Example 3
(Preparation of external preparation)
PEG # 400 and PEG # 4000 were mixed at a mixing ratio of 10: 3, and 7.0 g of hydrogen storage porous material and 2.0 g of organic acid (citric acid) were added thereto to prepare an external preparation. This external preparation was applied to the site of rheumatoid arthritis, and water was added. As a result, the analgesic effect was confirmed.

Example 4
(Preparation of external sheet)
The external preparation prepared in Example 3 was applied to the adhesive surface of a commercially available adhesive bandage tape having a diameter of 22 mm to prepare an external sheet. Water was added to the external sheet and attached to the site of low back pain. As a result, the analgesic effect was confirmed.

It is explanatory drawing which shows one Embodiment of the external preparation of this invention. It is a perspective view which shows one Embodiment of the external preparation sheet | seat of this invention. It is explanatory drawing which shows the usage method of an external sheet agent.

Explanation of symbols

1 External preparation 2 Stir ball 3 Push-type bottle (Airless pump)
4 Arrow 5 Sheet 6 Adhesive 7 Sheet for external use

Claims (9)

Contains a hydrogen storage porous material, an organic acid, and an anhydrous thickener,
The external preparation, wherein the anhydrous thickener has a viscosity of 20 to 30 mm ² / S.   The hydrogen storage porous material is at least one selected from the group consisting of hydrogen storage calcined coral calcium, hydrogen storage zeolite, hydrogen storage charcoal, hydrogen storage activated carbon, hydrogen storage barley stone, hydrogen storage tourmaline and hydrogen storage rare earth ore. The external preparation according to claim 1.   The external preparation according to claim 1 or 2, wherein the anhydrous thickener is polyethylene glycol.   The organic acid is at least one selected from the group consisting of citric acid, tartaric acid, lactic acid, glycolic acid, malic acid, dilute hydrochloric acid, acetic acid, oxalic acid and D-glucuronic acid. The external preparation according to one item.   The external preparation as described in any one of Claims 1-4 containing a stirring ball | bowl.   An external sheet agent, wherein the external preparation according to any one of claims 1 to 5 is applied to a sheet having an adhesive on one side.   The external preparation according to claim 7, wherein the external preparation is filled in a push-type bottle, and the external preparation is discharged and applied to the sheet.   An external sheet preparation set comprising a sheet having an adhesive on one side and the external preparation according to any one of claims 1 to 5.   The external sheet preparation set according to claim 8, comprising a push-type bottle filled with the sheet and the external preparation.

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