JP2010071897A - Automatic analysis device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an automatic analysis device can eliminate a time and effort required for cleaning a probe and reducing a time required for analytical processing. <P>SOLUTION: The automatic analysis device 1 includes cleaning liquid cleaning vessels 13 and 15 storing a cleaning liquid used for cleaning the probe, probe cleaning sections 11 and 12 cleaning the probe at least with the cleaning liquid, a liquid level decision unit 37 determining whether a level of the cleaning liquid in the cleaning liquid cleaning vessels 13 and 15 is less than a predetermined liquid level from measurement results by a liquid level sensor measuring a liquid level of the cleaning liquid in the cleaning liquid cleaning vessels 13 and 15, and cleaning liquid replenishing mechanisms in the cleaning liquid cleaning vessels 13 and 15, which replenish the cleaning liquid from the cleaning liquid remaining in the cleaning liquid cleaning vessels 13 and 15. The cleaning liquid replenishing mechanisms replenish the cleaning liquid from a decision of the liquid level decision unit 37, allowing an automatic supply of the cleaning liquid. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an automatic analyzer that automatically analyzes a sample by reacting the sample with a reagent.

  Conventionally, as a device that automatically analyzes specimens such as blood and body fluids, the specimen and reagent are dispensed into a reaction container, the specimen and reagent are reacted, and then the absorbance of the reaction liquid of this specimen and reagent is measured. An automatic analyzer that automatically analyzes a sample is known. In this automatic analyzer, when the dispensing probe is washed after dispensing the specimen and the reagent, a pure water such as a cleaning agent, ion-exchanged water, or distilled water is used as a washing liquid (see, for example, Patent Document 1).

JP-A-6-207944

  However, the probe cleaning shown in Patent Document 1 is a state in which the cleaning liquid is contained in the container, and the container needs to be replaced when the cleaning liquid in the container is exhausted. In addition to the time and effort required for the replacement work, it was also necessary to interrupt the analysis depending on the timing of the analysis.

  The present invention has been made in view of the above, and an object of the present invention is to provide an automatic analyzer that can eliminate the trouble of probe cleaning and reduce the time required for analysis processing.

  In order to solve the above-described problems and achieve the object, an automatic analyzer according to the present invention has a probe that sucks and discharges a specimen or a reagent to a reaction container, and the specimen and the reagent are put into the reaction container. A probe cleaning unit that has a cleaning container that contains a cleaning solution for cleaning the probe, and that uses at least the cleaning solution to clean the probe A liquid level sensor that measures the liquid level of the cleaning liquid in the cleaning container, and a cleaning liquid replenishing mechanism that replenishes the cleaning liquid from the cleaning liquid remaining in the cleaning container in the cleaning container. A replenishment control means for replenishing the cleaning liquid by the cleaning liquid replenishment mechanism when the amount of the cleaning liquid in the cleaning container is less than a predetermined liquid volume based on the measurement result by the liquid level sensor. It is characterized in.

  The automatic analyzer according to the present invention further includes a replenishment pipe for connecting the supply source for supplying the cleaning liquid and the cleaning container in the above invention, and the replenishment pipe is connected to the upper part of the cleaning container. In the cleaning container, the cleaning container is extended to the vicinity of the bottom surface of the cleaning container.

  The automatic analyzer according to the present invention is characterized in that, in the above invention, the replenishing pipe has an end bent along the bottom of the cleaning container.

  In the automatic analyzer according to the present invention as set forth in the invention described above, the cleaning liquid replenishing mechanism replenishes the cleaning liquid from an opening provided on a bottom side of the side surface of the cleaning container.

  The automatic analyzer according to the present invention includes a storage tank for storing the cleaning liquid in the above invention, and a plurality of the cleaning containers and the storage tanks are provided corresponding to the types of the cleaning liquid stock solutions. It is characterized by.

  The automatic analyzer according to the present invention is characterized in that, in the above invention, the cleaning container is provided with a discharge hole for discharging the cleaning liquid on a bottom surface of the cleaning container.

  The automatic analyzer according to the present invention is the automatic analyzer according to the above invention, wherein the cleaning container has an opening into which the probe is inserted on the upper part of the cleaning container and a lid that seals the opening. When the apparatus is turned off, the determination unit that determines whether the opening is sealed by the lid, and the determination unit determines that the opening is not sealed by the lid. And a notifying means for notifying that it is not blocked.

  In the automatic analyzer according to the present invention as set forth in the invention described above, the cleaning solution is a diluted solution obtained by mixing a cleaning solution stock solution and a diluted solution.

  According to the present invention, since the cleaning liquid is automatically supplied, the time required for the analysis process can be shortened, and the analysis process can be performed stably.

  Hereinafter, an automatic analyzer that analyzes a sample by dispensing a liquid sample such as blood or urine into a reaction container will be described as an example with reference to the drawings. Note that the present invention is not limited to the embodiments. In the description of the drawings, the same parts are denoted by the same reference numerals.

  FIG. 1 is a schematic diagram illustrating a configuration of an automatic analyzer according to an embodiment. As shown in FIG. 1, the automatic analyzer 1 according to the embodiment dispenses a sample and a reagent to be analyzed into a reaction vessel 10 and optically measures a reaction occurring in the dispensed reaction vessel 10. And a control mechanism 3 that controls the entire automatic analyzer 1 including the measurement mechanism 2 and analyzes the measurement result in the measurement mechanism 2. The analyzer 1 automatically performs biochemical analysis of a plurality of specimens through the cooperation of these two mechanisms. The reaction container 10 is a very small container having a capacity of several μL to several mL, and is a transparent material that transmits 80% or more of the light contained in the analysis light emitted from the light source of the photometry unit 28, such as heat resistant glass. Synthetic resins such as glass, cyclic olefin and polystyrene are used. The reaction vessel 10 is formed with a liquid holding portion that holds a liquid by a side wall and a bottom wall, and has an opening at the top of the liquid holding portion.

  First, the measurement mechanism 2 will be described. The measurement mechanism 2 roughly includes a sample transfer unit 21, a sample dispensing mechanism 22, a reaction table 23, a reagent storage 24, a reagent dispensing mechanism 26, a stirring unit 27, a photometric unit 28, and a cleaning unit 29.

  The sample transfer unit 21 includes a plurality of sample racks 21b that hold a plurality of sample containers 21a containing liquid samples such as blood and sequentially transfer them in the direction of the arrows in the figure. The sample in the sample container 21 a transferred to a predetermined position on the sample transfer unit 21 is dispensed by the sample dispensing mechanism 22 into the reaction container 10 that is arranged and transported on the reaction table 23.

  The sample dispensing mechanism 22 includes an arm 22a that freely moves up and down in the vertical direction and rotates around a vertical line passing through its base end as a central axis. A sample probe for aspirating and discharging the sample is attached to the tip of the arm 22a. The specimen dispensing mechanism 22 includes a suction / discharge mechanism using a suction / discharge syringe or a piezoelectric element (not shown). The sample dispensing mechanism 22 sucks the sample from the sample container 21a transferred to the predetermined sample suction position on the sample transfer unit 21 described above by the sample probe, and rotates the arm 22a clockwise in the drawing. Dispensing is performed by discharging the sample into the reaction container 10 transported to a predetermined sample discharge position on the reaction table 23.

  The reaction table 23 transfers the reaction container 10 to a predetermined position in order to dispense a sample or reagent into the reaction container 10, to stir, measure, and wash the reaction container 10. The reaction table 23 is rotatable about a vertical line passing through the center of the reaction table 23 as a rotation axis by driving a drive mechanism (not shown) under the control of the control unit 31. An openable / closable lid and a thermostat (not shown) are provided above and below the reaction table 23, respectively.

  The reagent storage 24 can store a plurality of reagent containers 24a in which reagents to be dispensed in the reaction container 10 are stored. A plurality of storage chambers are arranged at equal intervals in the reagent storage 24, and a reagent container 24a is detachably stored in each storage chamber. The reagent storage 24 can be rotated clockwise or counterclockwise with a vertical line passing through the center of the reagent storage 24 as a rotation axis by driving a drive mechanism (not shown) under the control of the control unit 31. The desired reagent container 24a is transferred to the reagent suction position by the reagent dispensing mechanism 26. An openable / closable lid (not shown) is provided above the reagent storage 24. A cold storage is provided below the reagent storage 24. For this reason, when the reagent container 24a is stored in the reagent storage 24 and the lid is closed, the reagent stored in the reagent container 24a is cooled to evaporate or denature the reagent stored in the reagent container 24a. Can be suppressed.

  Similar to the sample dispensing mechanism 22, the reagent dispensing mechanism 26 includes an arm 26 a to which a reagent probe for aspirating and discharging a reagent is attached at the tip. The arm 26a freely moves up and down in the vertical direction and rotates around a vertical line passing through its base end as a central axis. The reagent dispensing mechanism 26 includes a suction / discharge mechanism using a suction / discharge syringe or a piezoelectric element (not shown). The reagent dispensing mechanism 26 sucks the reagent in the reagent container 24a that has been moved to a predetermined reagent suction position on the reagent storage 24 with a probe, and rotates the arm 26a clockwise in the drawing to perform a predetermined on the reaction table 23. The reagent is discharged and dispensed into the reaction container 10 conveyed to the reagent discharge position. The stirring unit 27 stirs the sample dispensed into the reaction container 10 and the reagent to promote the reaction.

  For example, the photometry unit 28 irradiates the reaction vessel 10 transported to a predetermined photometry position with analysis light (340 to 800 nm) from a light source, splits the light transmitted through the liquid in the reaction vessel 10, and receives light from a PDA or the like. By measuring the intensity of each wavelength light by the element, the absorbance at a wavelength peculiar to the reaction solution of the sample to be analyzed and the reagent is measured. The photometry unit 28 outputs each measured absorbance to the control unit 31.

  The cleaning unit 29 sucks and discharges the mixed solution in the reaction container 10 that has been measured by the photometric unit 28 using the cleaning probe, and completes the analysis process by injecting and sucking cleaning liquid such as detergent and cleaning water. The reaction vessel 10 is washed.

  The probe cleaning units 11 and 12 include cleaning liquid cleaning containers 13 and 15 for cleaning the probe with a cleaning liquid, and water cleaning containers 14 and 16 for cleaning the probe with water. The sample dispensing mechanism 22 and the reagent dispensing mechanism 26 respectively clean the sample probe or the reagent probe by rotating the arms 22a and 26a to predetermined positions.

  Next, the control mechanism 3 will be described. The control mechanism 3 includes a control unit 31, an input unit 32, an analysis unit 33, a storage unit 34, an output unit 35, and a determination unit 36. These units included in the measurement mechanism 2 and the control mechanism 3 are electrically connected to the control unit 31.

  The control unit 31 is configured using a CPU or the like, and controls processing and operation of each unit of the automatic analyzer 1. The control unit 31 performs predetermined input / output control on information input / output to / from each of these components, and performs predetermined information processing on this information.

  The input unit 32 is configured using a keyboard, a mouse, and the like, and acquires various information necessary for analyzing the sample, instruction information for analysis operation, and the like from the outside. The analysis unit 33 performs component analysis of the specimen based on the absorbance measured by the photometry unit 28.

  The storage unit 34 is configured by using a hard disk that magnetically stores information and a memory that loads various programs related to the process from the hard disk and electrically stores them when the automatic analyzer 1 executes the process. Various information including the analysis result of the specimen is stored. The storage unit 34 may include an auxiliary storage device that can read information stored in a storage medium such as a CD-ROM, a DVD-ROM, or a PC card.

  The output unit 35 is configured using a display, a printer, a speaker, and the like, and outputs various information including the analysis result of the sample. The output unit 35 may output various information including the analysis result of the sample to an external device via a communication network (not shown).

  The determination unit 36 includes a liquid amount determination unit 37 and a blockage determination unit 38. The liquid amount determination unit 37 determines whether or not the cleaning liquid stored in the cleaning liquid cleaning containers 13 and 15 is less than a predetermined amount based on the liquid level information. Further, the blockage determination unit 38 determines whether or not the probe insertion ports of the cleaning liquid cleaning containers 13 and 15 are blocked.

  In the automatic analyzer 1 configured as described above, the sample dispensing mechanism 22 dispenses the sample in the sample container 21a to the plurality of reaction containers 10 that are sequentially conveyed in a row, and reagent dispensing. After the mechanism 26 dispenses the reagent in the reagent container 24a, the photometric unit 28 measures the spectral intensity of the reaction solution obtained by reacting the sample and the reagent, and the analysis unit 33 analyzes the measurement result, Analysis of the components is automatically performed. In addition, the cleaning unit 29 cleans the reaction container 10 that is transported after the measurement by the photometry unit 28 is completed, so that a series of analysis operations are continuously repeated.

  Here, the cleaning liquid replenishing mechanism of the cleaning liquid stored in the cleaning liquid cleaning containers 13 and 15 will be described with reference to FIG. FIG. 2 is a schematic diagram showing a cleaning liquid replenishment mechanism in the cleaning liquid cleaning container 13. The cleaning solution replenishment mechanism shown in FIG. 2 includes a stock solution tank 171 that stores a stock solution of the cleaning solution, a diluted solution tank 172 that dilutes the stock solution to a predetermined concentration, a tube 173 that connects the stock solution tank 171 and the diluted solution tank 172, and a stock solution. A dilution liquid tank 174 for storing a dilution liquid for diluting the liquid, a tube 176 for connecting the dilution liquid tank 174 and the dilution liquid tank 172, and a pipe 175 for connecting the dilution liquid tank 172 and the cleaning liquid cleaning container 13. A filter 173a for removing foreign matter is provided at the tip of the tube 173 on the stock solution tank 171 side. The tube 173 is provided with a stock solution pump 173b for controlling the injection of the stock solution in the stock solution tank 171 into the diluted solution tank 172 and the injection amount. The tube 176 is provided with a dilution pump 176a for controlling the injection of the diluent in the diluent tank 174 into the diluent solution tank 172 and the injection amount. The pipe 175 is provided with a liquid supply pump 175a for controlling the supply of the cleaning liquid in the diluted solution tank 172 to the cleaning liquid cleaning container 13 and the supply amount. As the diluent, purified water such as ion exchange water is usually used. The diluted solution tank 172 and the pipe 175 are made of a chemical resistant resin or coated with a chemical resistant resin. When the cleaning unit 29 and the cleaning liquid are the same, the pipe 175 may be connected to the cleaning unit 29 to control the liquid supply with a valve or the like and may be used in common.

  By the injection process of the stock solution pump 173b and the dilution pump 176a, a predetermined amount of the stock solution and a predetermined amount of the diluted solution are injected into the diluted solution tank 172 to prepare a diluted solution of a predetermined concentration. In the replenishment process, the diluted solution in the diluted solution tank 172 is supplied into the cleaning liquid cleaning container 13 through the pipe 175 by the supply process of the liquid supply pump 175a under the control of the control unit 31, and the cleaning liquid is replenished. The Here, the pipe 175 extends to the vicinity of the bottom of the cleaning liquid cleaning container 13, and has an effect of suppressing the foaming of the cleaning liquid when the cleaning liquid is added. Moreover, the pipe | tube 175 and the washing | cleaning liquid washing | cleaning container 13 can be removed arbitrarily, and the washing | cleaning liquid washing | cleaning container 13 can be taken out.

  Further, the cleaning liquid cleaning container 13 has a liquid level sensor 132 that detects the amount of diluted solution in the cleaning liquid cleaning container 13. The liquid level sensor 132 may be, for example, a sensor that self-heats the thermistor and determines the presence or absence of liquid using the temperature change characteristic of the thermistor that changes depending on the presence or absence of the liquid. The liquid level may be determined. The liquid level information from the liquid level sensor 132 is output to the liquid level determination unit 37, and when the liquid level determination unit 37 determines that the cleaning liquid in the cleaning liquid cleaning container 13 is less than the predetermined amount, the control unit 31 The pump 173b and the dilution pump 176a are injected, and a predetermined amount of stock solution and a predetermined amount of diluent are injected into the diluted solution tank 172 to create a cleaning solution, and the cleaning solution cleaning container 13 is replenished via the pipe 175. .

  The probe is washed by inserting the sample probe into the probe insertion port 131 of the cleaning solution cleaning container 13 and sucking the cleaning solution to clean the inside of the sample probe, and lowering the sample probe and immersing it in the cleaning solution. The outer peripheral side surface of the probe can be cleaned. The suctioned cleaning liquid is discharged into the water cleaning container 14.

  Here, the water washing container 14 will be described with reference to FIG. FIG. 3 is a schematic diagram showing the water washing container 14 of the automatic analyzer 1 shown in FIG. When the arm 22a comes to a predetermined position by the sample dispensing mechanism 22, the sample dispensing mechanism 22 lowers the arm 22a. The specimen probe 221 is inserted into the water washing container 14 from the probe insertion port 141 by the lowering of the arm 22a. When the sample probe 221 is inserted, the control unit 31 operates the liquid feeding pump 182a to send the cleaning water in the cleaning water tank 181 from the cleaning water inlet 142 into the water cleaning container 14 via the pipe 182. Then, the outer peripheral side surface of the sample probe 221 is washed. The sample probe 221 can be cleaned by the sample probe 221 sucking the cleaning water stored in the water cleaning container 14. The cleaning water accumulated in the water cleaning container 14 is discharged from the cleaning water discharge port 143 through the pipe 184 to the waste liquid tank 183, thereby discarding the cleaning water in which the contamination of the sample probe in the water cleaning container 14 is taken in. Thus, contamination in the next probe cleaning can be prevented and the cleaning accuracy can be maintained. The washing water discharge port 143 is controlled to be discharged by a valve (not shown).

  Moreover, the modification of the pipe | tube 175 shown in FIG. 2 is demonstrated using FIG. FIG. 4 is a schematic diagram showing a first modification of the tube 175 in the cleaning liquid replenishment mechanism shown in FIG. The end of the pipe 175 inside the cleaning liquid cleaning container 13 of the pipe 175 is bent in parallel with the bottom of the cleaning liquid cleaning container 13. By discharging the cleaning liquid in parallel with the bottom of the cleaning liquid cleaning container 13, the foaming suppression effect can be further improved. In the cleaning liquid replenishment mechanism, the pipe 175 may be arranged as shown in FIG. FIG. 5 is a schematic diagram showing a second modification of the tube 175 in the cleaning liquid replenishment mechanism shown in FIG. The pipe 175 is connected to the bottom of the side wall of the cleaning liquid cleaning container 13. By connecting the pipe 175 to the bottom, the cleaning liquid is discharged to the cleaning liquid cleaning container 13 by discharging the cleaning liquid parallel to the bottom of the cleaning liquid cleaning container 13 in the same manner as the arrangement of the pipe 175 of the first modification shown in FIG. There is an effect of suppressing foaming of the cleaning liquid.

  Further, the cleaning liquid cleaning container 13 may include a waste liquid tank 134 at the bottom. FIG. 6 is a schematic diagram showing a third modification of the cleaning liquid cleaning container 13 of the cleaning liquid replenishment mechanism shown in FIG. In the third modification, a cleaning liquid discharge port 133 provided at the bottom of the cleaning liquid cleaning container 13 is connected to the waste liquid tank 134. By providing the waste liquid tank 134, the cleaning liquid remaining inside can be discharged when the cleaning liquid is replaced as required, and the cleaning liquid sucked by the probe can be replaced with a new liquid even when discharged into the cleaning liquid cleaning container 13. Thus, the effect of preventing contamination can be improved. Further, even if the probe repeatedly sucks and discharges in the cleaning liquid, it can be arbitrarily replaced with a new liquid, so that the cleaning accuracy can be maintained. The discharge of the cleaning liquid discharge port 133 is controlled by a valve (not shown). By providing the cleaning liquid discharge port 133, it is possible to cope with a case where a plurality of cleaning liquid stock solutions are provided.

  The replacement of the cleaning liquid is performed by installing a plurality of dilution solution tanks 172 shown in FIG. 2 corresponding to the stock solution of the cleaning liquid (stock solution tank 171), a newly installed dilution solution tank 172, a newly installed dilution solution tank 172, This is possible by newly arranging a pipe 175 communicating with the cleaning liquid cleaning container 13. When the diluting solution is the same, a valve is provided in the tube 176 to control the liquid feeding and dilute each cleaning solution stock solution. In addition, the cleaning liquid fed into the cleaning liquid cleaning container 13 may be controlled by installing a valve in the pipe 175 and changing the flow path. When the cleaning solution stock solution is the same and the concentration is changed, the dilution solution or the cleaning solution stock solution is added to the dilution solution tank 172 based on the remaining amount and concentration of the cleaning solution remaining in the dilution solution tank 172. Prepare a cleaning solution with a modified concentration. If the properties of acid, alkali, etc. are the same even if the other cleaning solution stock solution is used, the diluted solution tank 172 may be washed before use. In the cleaning of the diluted solution tank 172, the diluted solution is cleaned, and the diluted solution is sent from the diluted solution tank 172 to the cleaning solution cleaning container 13 via the pipe 175 and discarded in the waste solution tank. The solution tank 172, the pipe 175, and the cleaning liquid cleaning container 13 can be cleaned.

  Here, the cleaning liquid cleaning container 13 is preferably provided with a lid 135 at the probe insertion port 131. FIG. 7 is a schematic view showing a fourth modification of the cleaning liquid cleaning container 13 of the cleaning liquid replenishment mechanism shown in FIG. In particular, when an acidic cleaning liquid is used, by providing the lid 135, the influence of the volatile cleaning liquid on the apparatus can be prevented. The lid 135 is operated by the control of the control unit 31 to open and close the probe insertion port 131. When the device is turned off, if the blockage determination unit 38 determines that the probe insertion port 131 is not blocked by the lid 135, the control unit 31 notifies that the probe insertion port 131 is not blocked. An instruction is issued to the output unit 35. The blockage determination unit 38 determines whether or not the probe insertion port 131 is blocked using magnetic sensors provided on the inner wall of the probe insertion port 131 and the inside of the lid 135. In addition, you may determine with the sensor installed in the probe insertion port 131 vicinity.

  A plurality of cleaning liquid cleaning containers may be provided. FIG. 8 is a schematic diagram showing a modification of the automatic analyzer 1 shown in FIG. In FIG. 8, cleaning liquid cleaning containers 15 and 17 are provided in the probe cleaning unit 12. For example, when the cleaning liquid used for the treatment is acidic and alkaline, it is dangerous to mix and it takes time to replace the cleaning liquid. By selecting the cleaning liquid cleaning containers 15 and 17 and cleaning the probe, it is possible to avoid danger due to mixing of acid and alkali. By providing a plurality of cleaning liquid cleaning containers, it is possible to cope with a case where a plurality of cleaning liquids are required in the analysis process. The probe may be cleaned by storing the same cleaning liquid in a plurality of cleaning liquid cleaning containers.

  In the automatic analyzer according to the present embodiment, the liquid volume determination unit determines whether or not the cleaning liquid is replenished from the liquid level information of the cleaning liquid in the cleaning liquid cleaning container, and the cleaning liquid replenishment mechanism replenishes the cleaning liquid automatically. It becomes possible to replenish the cleaning liquid. In addition, a liquid level sensor installed in the cleaning liquid cleaning container by suppressing the foaming when the cleaning liquid is replenished by arranging a tube for replenishing the cleaning liquid in the cleaning liquid cleaning container near the bottom of the cleaning liquid cleaning container, Or the misdetection of the liquid level sensor for dispensing installed in each probe can be prevented.

  The cleaning liquid replenishment mechanism shown in FIG. 2 is also applied to the cleaning liquid cleaning containers 15 and 17, and the water cleaning container 16 has the same configuration as the water cleaning container 14 shown in FIG.

  Further, the present invention is not limited to the above-described embodiment, and can be applied to, for example, an automatic analyzer that performs immunological analysis of a specimen. That is, the present invention can include various embodiments and the like not described herein, and various design changes and the like can be made without departing from the technical idea specified by the claims. Is possible.

It is a schematic diagram which shows the structure of the automatic analyzer concerning embodiment. It is a schematic diagram which shows the washing | cleaning-liquid replenishment mechanism of the automatic analyzer shown in FIG. It is a schematic diagram which shows the water washing container of the automatic analyzer shown in FIG. It is a schematic diagram which shows the modification 1 of the pipe | tube in the washing | cleaning-liquid replenishment mechanism shown in FIG. It is a schematic diagram which shows the modification 2 of the pipe | tube in the washing | cleaning-liquid replenishment mechanism shown in FIG. FIG. 10 is a schematic diagram showing a third modification of the cleaning liquid cleaning container of the cleaning liquid replenishment mechanism shown in FIG. 2. FIG. 10 is a schematic diagram showing a fourth modification of the cleaning liquid cleaning container of the cleaning liquid replenishment mechanism shown in FIG. 2. It is a schematic diagram which shows the modification of a structure of the automatic analyzer shown in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Automatic analyzer 2 Measurement mechanism 3 Control mechanism 10 Reaction container 11,12 Probe washing | cleaning part 13,15,17 Cleaning liquid washing container 14,16 Water washing container 131,141 Probe insertion port 132 Liquid level sensor 133 Cleaning liquid discharge port 134 Waste liquid tank 135 Lid 142 Washing water inlet 143 Washing water outlet 171 Stock solution tank 172 Dilution solution tank 173,176 Tube 173a Filter 173b Stock solution pump 174 Dilution solution tank 175,182,184 Tube 175a Supply pump 176a Dilution pump 181 Washing water tank 182a Liquid feed pump 183 Waste liquid tank 21 Sample transfer part 21a Sample container 21b Sample rack 22 Sample dispensing mechanism 221 Sample probe 22a, 26a Arm 23 Reaction table 24 Reagent 24a Reagent container 26 Reagent Mechanism 27 stir unit 28 measuring unit 29 cleaning unit 31 control unit 32 input unit 33 analyzing unit 34 memory unit 35 output unit 36 determination unit 37 liquid amount determining unit 38 blockade determination unit

Claims (8)

In an automatic analyzer that has a probe that sucks and discharges a sample or a reagent into a reaction vessel, and automatically analyzes the sample by reacting the sample and the reagent in the reaction vessel,
A cleaning container containing a cleaning solution for cleaning the probe, and a probe cleaning unit for cleaning the probe using at least the cleaning solution;
A liquid level sensor for measuring the liquid level of the cleaning liquid in the cleaning container;
A cleaning liquid replenishing mechanism for replenishing the cleaning liquid from the cleaning liquid remaining in the cleaning container in the cleaning container;
From the measurement result by the liquid level sensor, when the amount of the cleaning liquid in the cleaning container is less than a predetermined liquid amount, a replenishment control means for replenishing the cleaning liquid by the cleaning liquid replenishment mechanism;
An automatic analyzer characterized by comprising: A replenishment pipe connecting the supply source for supplying the cleaning liquid and the cleaning container;
2. The automatic analyzer according to claim 1, wherein the replenishment pipe is connected to an upper portion of the cleaning container and is extended to the vicinity of the bottom surface of the cleaning container in the cleaning container.   The automatic analyzer according to claim 2, wherein an end of the supplementary pipe is bent along the bottom of the cleaning container.   The automatic analyzer according to claim 1, wherein the cleaning liquid replenishing mechanism replenishes the cleaning liquid from an opening provided on a bottom side of the side surface of the cleaning container. A storage tank for storing the cleaning liquid;
5. The automatic analyzer according to claim 1, wherein a plurality of the cleaning containers and the storage tanks are provided corresponding to types of the cleaning liquid stock solutions.   6. The automatic analyzer according to claim 1, wherein the cleaning container is provided with a discharge hole for discharging the cleaning liquid on a bottom surface of the cleaning container. The cleaning container has an opening for inserting a probe in the upper part of the cleaning container and a lid for sealing the opening,
Determining means for determining whether or not the opening is blocked by the lid when the automatic analyzer is powered off;
When the determination means determines that the opening is not sealed with a lid, notification means for notifying that the opening is not sealed;
The automatic analyzer according to any one of claims 1 to 6, further comprising:   The automatic analyzer according to any one of claims 1 to 7, wherein the cleaning liquid is a diluted solution obtained by mixing a cleaning liquid stock solution and a diluent.

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