JP2010057827A - Device holder and sheet for living body - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a device holder which can fix an implanting artificial device in a living body to prevent it from adhering to a living tissue. <P>SOLUTION: The device holder 8 includes a first holder 1 which is an inner side member facing the holding space of the device holder 8 and a second holder 2 which is an outer side member, and holds an artificial device 3 to form an implanting construct 9, wherein the first holder 1 is made of an adhesion preventive material which does not adhere or is poor to adhere to a living tissue; and the second holder 2 is made of an adhesive material which more highly adheres to the living tissue than that of the first holder 1. The implanting construct 9, which is buried inside a living body, is easy to be fixed into the living body, because the outer surface of the second holder 2 comes into contact with the living tissue to adhere to each other, while the artificial device 3 is hard to adhere to the living tissue, because the first holder 1, which is an inner side member of the device holder 8, is made of the adhesion preventive material. An electrode unit 4 penetrates the through-hole 81 of the device holder 8 to exert an action from the artificial device 3 on the living body. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a device container and a living body sheet for housing an implantable artificial device.

  Artificial devices have been developed that are implanted in living bodies such as humans. Artificial devices implanted in the body include a function assisting device for supplementing the function of a living body in which a disease has occurred, a monitoring device for detecting abnormalities in the living body, and the like. For example, as an example of an implantable function assisting device, there is a cardiac pacemaker that assists the function of pumping blood to the whole body. In general, a cardiac pacemaker includes a battery such as a lithium battery, a device that generates electrical stimulation at a set cycle, and an electric wire that transmits the generated electrical stimulation to the heart. Among these, the lifetime of a battery is comparatively short and is 5 to 10 years. Thus, a typical cardiac pacemaker must be replaced after a period of 5 to 10 years after surgery. Also, other parts of the cardiac pacemaker need to be replaced if any failure is recognized. In order to replace an implantable artificial device such as a cardiac pacemaker, a surgical operation for incising the site in which the device is implanted is required. However, an implantable artificial device may adhere to surrounding living tissue as the period elapses after surgery. As a result, it is necessary to remove the tissue adhered by the operation of removing the artificial device from the body, which is a burden on the doctor who performs the operation and the patient who receives the operation.

By the way, when a living tissue is damaged, adhesion occurs between damaged tissues or between a damaged tissue and another living tissue, which may cause various malfunctions. Various anti-adhesion membranes have been developed to prevent this adhesion. For example, Patent Document 1 describes an adhesion preventing material composed of a human-derived natural collagen membrane. Patent Document 2 describes an adhesion preventing material composed of a hyaluronic acid compound that is a reaction product of hyaluronic acid and phosphatidylethanolamine. Patent Document 3 describes an adhesion preventing material comprising a dry film of a polyion complex formed from a polyanionic substance and a polycationic substance.
Japanese Patent Laid-Open No. 9-2225018 JP 2006-296916 A JP 2000-116765 A

When an artificial device is implanted in the body, it is necessary to quickly fix the artificial device in the body and stabilize its position.On the other hand, considering the possibility of replacement, excessive adhesion between the artificial device and living tissue may occur. Must be prevented. In addition, depending on the type of artificial device, in order to perform some useful function for the living body, it may be necessary to maintain a state in which the living body is communicated with the electrode or the like.
The present invention has been made in view of such a background, and is intended to reduce adhesion to a living tissue while fixing an implantable artificial device in the body in a state where its function can be realized. Objective.

In order to solve the above-described problems, a device container according to the present invention is formed of an adhesion prevention film having an action of preventing adhesion with a living body, and includes a first accommodation space for accommodating an artificial device, and the first A first housing body having a first hole penetrating the inside and outside of the housing space, and a second housing space formed of an adhesion film having an action of adhering to a living body and housing the first housing body; And a second container having a second hole penetrating the inside and outside of the second accommodation space.
As a result, it is possible to reduce adhesion to the living tissue while fixing the implantable artificial device in the body in a state where its function can be realized.

Preferably, a hollow cylindrical member inserted into the second hole, the outer peripheral surface having a function of adhering to the inner edge of the second hole may be provided.
Thereby, an apparatus container can be designed irrespective of the thickness of members, such as an electrode which penetrates the inside and outside of an apparatus container.

Preferably, the cylindrical member is compressed by receiving pressure from an inner edge of the second hole and in close contact with the second hole in a state of being inserted into the second hole.
Thereby, compared with the case where such a structure is not used, possibility that a biological tissue will enter from the clearance gap between holes can be reduced.

Preferably, the cylindrical member is provided with a portion that is gradually thickened in the axial direction and has a tapered shape, and a portion of the tapered shape cannot pass through the second hole. It should be.
Thereby, compared with the case where such a structure is not used, possibility that a biological tissue will enter from the clearance gap between holes can be reduced.

Preferably, in the adhesion film forming the second container, the thickness of the peripheral portion of the second hole is larger than the thickness of the portion other than the peripheral portion.
Thereby, compared with the case where such a configuration is not used, the possibility that a living tissue enters from the gap of the hole is reduced, and the possibility that the container is damaged by increasing the strength around the hole is reduced. be able to.

Further, the biomedical sheet according to the present invention has an action of preventing adhesion with a living body, and has an action of adhering to a living body, an adhesion preventing sheet provided with a hole penetrating the front and back of the own sheet, An adhesion sheet that is bonded to one surface of the adhesion prevention sheet and has a hole penetrating the front and back of the sheet at a position overlapping with a hole provided in the adhesion prevention sheet. .
As a result, it is possible to reduce adhesion to the living tissue while fixing the implantable artificial device in the body in a state where its function can be realized.

The best mode for carrying out the present invention will be described.
[Embodiment]
(1. Structure of artificial device and electrode unit)
FIG. 1 is a conceptual diagram showing the structure of an artificial device 3 and an electrode unit 4 according to the present invention. The artificial device 3 is an implantable artificial device, and here is a cardiac pacemaker. The artificial device 3 includes a battery (not shown) and an IC chip that generates electrical stimulation at a set cycle, and an insertion port for transmitting the generated electrical stimulation to the electrode unit 4 on the surface of the artificial device 3. 31 is provided. The electrode unit 4 is a unit for transmitting electrical stimulation periodically generated by the artificial device 3 to the myocardium, and includes a connector 41, an electric wire 42 and an electrode end 43. The connector 41 of the electrode unit 4 is inserted into the insertion port 31 of the artificial device 3. Thereby, the electrical stimulation generated from the artificial device 3 is transmitted through the insertion port 31, the connector 41, and the electric wire 42, and is released from the electrode end 43 attached to the myocardium. The device housing 8 is a bag-like film material and houses the artificial device 3 on the inner surface side. In FIG. 1, only a part of the device housing 8 is shown. As shown in the figure, the electric wire 42 of the electrode unit 4 passes through a through hole 81 that penetrates the apparatus housing 8. The through-hole 81 is a hole having a size substantially the same as the cross section of the electric wire 42 and presses and fixes the electric wire 42 from the periphery. Therefore, there is almost no gap between the through-hole 81 and the electric wire 42 penetrating the through-hole 81, and the living tissue does not enter from the outer surface side to the inner surface side of the device housing 8 through the through-hole 81. It is desirable that the thickness of the peripheral portion of the through hole 81 is thicker than the thickness of the portion other than the peripheral portion. This is because the force around the through hole 81 is easily applied by the electric wire 42 and is easily damaged, so that the strength is required and it is necessary to prevent the invasion of the living tissue.

(2. Structure of embedded structure)
FIG. 2 is a conceptual diagram showing the structure of the embedded structure 9 according to the present invention. As shown in FIG. 2A, the device housing 8 is provided with an opening L1 at one end, and a through hole 81 is provided at one end opposite to the opening L1. The electric wire 42 of the electrode unit 4 passes through the through hole 81. The device housing 8 is integrated with the electrode unit 4 in a state in which the electrode end 43 is disposed on the outer surface side and the connector 41 is disposed on the inner surface side. The artificial device 3 is moved from the opening L <b> 1 in the direction of the arrow in the figure, and is placed inside the device housing 8. Then, the connector 41 of the electrode unit 4 is inserted into the insertion port 31 of the artificial device 3. The state of the device housing 8 in which the artificial device 3 is placed is shown in FIG. By joining the opening L <b> 1 of the device housing 8, the device housing 8 houses the artificial device 3 and forms the embedded structure 9. The embedded structure 9 formed by bonding the opening L1 is shown in FIG.

  FIG. 3 is a diagram for explaining the internal structure of the embedded structure 9. In the figure, the electrode unit and the through hole 81 are omitted. FIG. 3B is a cross-sectional view of the cross section passing through IIIb-IIIb shown in FIG. As shown in the figure, the device housing 8 has a configuration in which two bag-like members are stacked inside and outside. The member on the inner surface side of the device container 8 facing the accommodation space for accommodating the artificial device 3 is the first container 1, and the member on the outer surface side is the second container 2. And the embedded structure 9 is formed by accommodating the artificial device 3 by the device container 8, that is, the first container 1 and the second container 2.

(3. Materials of first container and second container)
Here, the material of the first container 1 and the second container 2 will be described. The material of the first container 1 is a film-like adhesion preventing material having an action of preventing adhesion with a living body. Here, “the action of preventing adhesion with a living body” means that it does not adhere to living tissue or has poor adhesion. Examples of the anti-adhesion material include polyion complexes after gelation, hyaluronic acid crosslinked with a non-bioabsorbable substance such as bisepoxide crosslinked hyaluronic acid, divinylsulfone crosslinked hyaluronic acid, formaldehyde crosslinked hyaluronic acid, and the like. And glycosaminoglycan to which lipid is bound. Since the material of the first container 1 does not adhere to the living tissue or has poor adhesion, adhesion between the artificial device 3 and the living tissue is prevented. The adhesion preventing material is preferably a material that does not adhere to the living tissue at all.

  The material of the second container 2 is a film-like adhesion material having an action of adhering to a living body. Here, “the action of adhering to the living body” means that the adhesion to the living tissue is higher than that of the adhesion preventing material that is the material of the first container 1 and it is easy to adhere to the living tissue. Therefore, as this adhesion material, for example, a dry film of a polyion complex formed from a polyanionic substance and a polycationic substance before completion of gelation, a solubilized collagen material, a human-derived natural collagen material, etc. Can be mentioned. It is desirable that the adhesive material has a high biocompatibility and has an adhesive property to such an extent that it is fixed to a site in the body in which the embedded structure 9 is embedded when the operation is completed. Moreover, it is desirable to have the retention property which retains for 5 to 10 years in a body. Therefore, it is desirable that the adhesive material has low in vivo absorbability and biodegradability.

(4. Effects of the embedded structure in the body)
When the embedded structure 9 having the above configuration is embedded in a human body or the like, the outer surface of the second container 2 constituting the embedded structure 9 comes into contact with the living tissue. Since the outer surface of the second container 2 causes adhesion with the living tissue that has come into contact, the embedded structure 9 is easily fixed in the body. Therefore, the artificial device 3 housed in the device housing 8 is also easily fixed in the body. That is, since the second container 2 that is a member on the outer surface side of the embedded structure 9 is made of an adhesive, the entire embedded structure 9 is fixed at the embedded position as compared with the case where this configuration is not used. It becomes easy.

  On the other hand, inside the embedded structure 9, the artificial device 3 and the living tissue are blocked by the device container 8. And since the 1st container 1 which is a member of the inner surface side of the apparatus container 8 does not have the adhesiveness with a biological tissue at all, or uses the adhesion prevention material with a poor adhesiveness as a material, the artificial device 3 is a biological tissue. It becomes difficult to adhere to.

(5. Removal and replacement of artificial devices)
Next, the extraction operation of the artificial device 3 will be described. After 5 to 10 years from the operation, the artificial device 3 whose function has been reduced must be removed from the body and repaired or replaced. At this time, since the outer surface of the second container 2 is adhered to the surrounding biological tissue, it is difficult to extract the artificial device 3 together with the embedded structure 9 from the body. On the other hand, the artificial device 3 is accommodated in the first container 1 without adhering to the living tissue. Therefore, in the operation of extracting the artificial device 3 of the embedded structure 9 out of the body, the opening L1 to which the device container 8 is joined is opened again, and the artificial device 3 is taken out from the opening L1.

  Then, after the artificial device 3 is removed, it is repaired or replaced, and then implanted again in the body in an implantation operation. In this case, the artificial device 3 having the same size as the extracted artificial device 3 is accommodated in the device housing 8 that is left in the living body while being adhered through the opening L1. As described above, the opening L1 is joined, and the device housing 8 houses the artificial device 3, whereby the embedded structure 9 is formed again.

  With the above configuration, the surgical operation and the implantation operation of the artificial device 3 need only be provided with the opening L1 having a size that allows the artificial device 3 to be taken in and out of the device housing 8. That is, with this configuration, the extraction operation and the implantation operation of the artificial device 3 are easier than when this configuration is not used. Moreover, the burden on the doctor who performs this operation and the patient who receives this operation is reduced.

[Modification]
The above is the description of the embodiment, but the contents of this embodiment can be modified as follows. Further, the following modifications may be combined as appropriate.
(Modification 1)
In the above-described embodiment, the size of the device housing 8 is not particularly mentioned except that the artificial device 3 is housed on the inner surface side, but the device housing 8 houses the artificial device 3 on the inner surface side. It may be larger than the smallest possible size. In addition, the artificial device 3 is inserted and removed from the opening L1 both when it is removed from the body during the extraction operation and when it is embedded in the body during the implantation operation. However, the artificial device 3 is provided at a different site from the opening L1. It may be taken in and out from the opening.

  FIG. 4 is a view for explaining an extraction operation of the artificial device 3 according to the first modification. FIG. 4B is a cross-sectional view of the cross section passing through IVb-IVb shown in FIG. FIG. 5 is a diagram showing an outline of the device housing 8 according to the first modification. In the figure, a frame drawn with a solid line represents the initial size of the apparatus housing 8. Here, an opening L <b> 1 is provided at the end of the device housing 8, and the artificial device 3 is taken in and out of the inner surface of the device housing 8 from here. When the opening L1 is joined and closed, a housing space for housing the artificial device 3 is formed in the device housing 8, and the device housing 8 houses the artificial device 3. Here, the minimum size of the device housing 8 necessary for housing the artificial device 3 is a portion described on the left side in FIG. 5 from a two-dot chain line L4. That is, the device housing 8 has extra sizes of the two-dot chain lines L1 to L4 in addition to the size necessary for housing the artificial device 3. Hereinafter, these two-dot chain lines L1 to L4 are referred to as joining range portions.

  After housing the artificial device 3, the opening L1 of the device housing 8 is joined and closed by mechanical stitching using an auto-suture. Next, when performing an extraction operation for taking out the artificial device 3 outside the body, a doctor who performs the operation cuts the device housing 8 of the embedded structure 9 along the two-dot chain line L2 shown in FIGS. Thereby, the two-dot chain line L2 becomes the opening L2, and the artificial device 3 is taken out from the opening L2. And the site | part from the opening part L2 to the opening part L1 joined to the opening part L1 is taken out outside the body and discarded, and the remaining apparatus container body 8 is left in the body. Next, the artificial device 3 is repaired or exchanged, and the artificial device 3 having the same size as the taken-out artificial device 3 is inserted into the device housing 8 through the opening L2. Thus, after the artificial device 3 is newly inserted, the opening L2 of the device housing 8 is joined and closed. Thereafter, every time a surgical operation for repairing or replacing the artificial device 3 is performed, the two-dot chain lines L2, L3, and L4 shown in the figure are cut in this order, and the respective cut portions become openings, and artificial After the first container 1 containing the device 3 is taken in and out, it is closed. That is, the second container 2 has an opening in which the first container 1 can be taken in and out, and a joining range part in a predetermined range that continues to the periphery of the opening, and the joining range part is joined and closed. Thus, an accommodation space for accommodating the first container 1 is formed, and the joining range portion is set to a size that allows one or more rejoining after the joining portion is cut off. Moreover, the 1st container 1 has the opening part which can withdraw / insert the artificial apparatus 3, and the joining range part of the predetermined range connected to the circumference | surroundings of this opening part, and by joining and closing this joining range part An accommodation space for accommodating the artificial device 3 is formed, and the joining range portion is set to a size that allows one or more rejoining after the joining portion is cut off.

  Accordingly, since the artificial device 3 can be taken in and out only by excising the periphery of the joined opening of the second container 2, the labor of the operation can be saved and the burden on the doctor performing the operation and the patient undergoing the operation. Is reduced. Moreover, if incision and joining are repeated for the same part of the device container 8, joining at that part may be difficult. In this modified example 1, since a new opening is provided by incising a part different from the joined part, the apparatus housing 8 can be easily joined.

  In the second container 2 shown in FIG. 5, the two-dot chain lines L2 to L4 may actually be drawn on the outer surface of the second container 2 as two-dot chain lines or solid lines. That is, the display which shows the position which should cut out a junction part, or the position which should join and close may be given to the junction range part. This may be drawn, for example, by weaving a dye having an affinity for the adhesion film, which is the material of the second container 2, or by previously sewing a suture thread having low biodegradability. , May be drawn. With such a two-dot chain line or a solid line display, the doctor who performs the operation can clearly know the position of the device container 8 to be next excised or joined, and perform the operation according to this display. In addition, this display allows the doctor to clearly know the number of times the device container 8 can be cut and to make a surgical plan accordingly. Furthermore, such a two-dot chain line or a solid line may be drawn using a material that can be photographed by an X-ray photograph or the like. In this case, the doctor can know the number of times that the device container 8 can be cut by an X-ray photograph or the like without performing a surgical operation. Further, although the number of the two-dot chain lines L2 to L4 is three, the number of two-dot chain lines may be more or less than three. The two-dot chain lines L2 to L4 are preferably parallel to the opening L1. This is because the cross-section cut by each two-dot chain line does not have to be affected by the nearest opening, and therefore it is sufficient if there is a minimum distance between them. And it is desirable that the joining range portion is farther from the through hole 81. This is because the electric wire 42 is present in the vicinity of the through-hole 81 and is not suitable for a cutting location. The farther the joining range portion is from the through-hole 81, the more locations where the device housing 8 can be cut. .

(Modification 2)
The second container 2 is an adhesion material, and some adhesion materials are easily decomposed in the body. In the above embodiment, the means for the surgeon to know the degree to which the second container 2 was decomposed by contact with the surrounding living tissue was not mentioned, but means for knowing the degree to which this was decomposed. May be provided. For example, the second container 2 has a plurality of layers from the inner surface side to the outer surface side in a state in which the first container 1 is accommodated, and each of the plurality of layers includes a second container. You may make it have the external appearance which shows which layer extends from the inner surface side of the body 2 to the outer surface side. That is, in this modified example 2, when the outer surface that does not face the second accommodation space is eroded, the adhesion film forming the second container 2 is eroded with the outer surface after being eroded. The front outer surface is configured to have a different appearance. The appearance may be characters and symbols drawn by the dye contained on the surface of each layer, the color of the dye itself, or the like. For example, the plurality of layers constituting the second container 2 may be blue on the outer surface side and red on the inner surface side, and each layer may be colored with an intermediate color of red and blue depending on the position of the layer. FIG. 6 is a conceptual diagram for explaining the second modification. In the example shown in the figure, the second container 2 includes three layers, and the layers 2-1 and layers are directed from the outer surface side (that is, the living body side) toward the inner surface side (that is, the first container 1 side). 2-2 and layer 2-3 are stacked in this order. Since these three layers are colored with different color pigments, different colors are visually observed when the layer 2-1 is peeled off and when the layer 2-2 is peeled off. The number of layers may be two, or four or more.

  In addition, the character indicating “1” is described on the outer surface of the innermost layer of the second container 2, and the character indicating “2” is indicated on the outer surface of the layer adjacent to the outer surface of this layer. In this case, it may be indicated which layer extends from the inner surface side to the outer surface side of the second container 2. For example, when the doctor visually recognizes the outer surface of the second container and recognizes the character “2”, the doctor decomposes the third and subsequent layers of the second container 2 as counted from the inner surface due to decomposition by the living body. It is only necessary to grasp that the second container 2 is composed of two layers at the present time. That is, the display allows the doctor performing the operation to know the degree to which the second container 2 has been decomposed by contact with the surrounding living tissue, and therefore determines when the second container 2 should be replaced. Can do.

In the second modification, the second container 2 has a plurality of layers, and each layer has an appearance that identifies itself discretely, but the second container 2 has a plurality of layers. You may make it have the external appearance which identifies the thickness which remains without having. For example, the second container 2 may be formed by dispersing and mixing the pigment so that the pigment concentration increases as it approaches the inner surface side. Thereby, a doctor confirms the color of the 2nd container 2 visually, and recognizes that the 2nd container 2 is thin, so that the color becomes dark.
Similarly to the second container 2 described above, the first container 1 may also be provided with means for the doctor to know the degree of decomposition by contact with the surrounding living tissue.

(Modification 3)
In the above-described embodiment, when the artificial device 3 is housed in the device housing 8, the opening is joined, but portions other than the opening may be joined. FIG. 7 is a view for explaining a joining mode in the third modification. FIG. 7B is a cross-sectional view of the cross section passing through VIIb-VIIb shown in FIG. As shown in FIG. 7A, in the third modification, after the artificial device 3 is put into the device housing 8, not the opening L1, but two points closer to the artificial device 3 than the opening L1. The chain line L2 is joined. Since the opening is the end of the membrane, for example, the suture thread may be easily loosened and joining may be difficult. If it does in this way, since there exists a film | membrane on the both sides of the site | part to join, since a suture is easy to be fixed, joining becomes easy.

(Modification 4)
In the above-described embodiment, the first container 1 and the second container 2 may be bonded in advance. In short, the first container 1 is formed on the inner surface side of the device container 8 with an adhesion preventing material that prevents adhesion to the living body, and the outer surface side of the first container 1 is made of an adhesion material that adheres to the living body. What is necessary is just to have the 2nd container 2 formed. Moreover, in the above-mentioned embodiment, although the 1st container 1 and the 2nd container 2 were bag shape, a sheet form may be sufficient. For example, the apparatus container 8 may be formed by bonding the sheet-like second container 2 to one surface of the sheet-like first container 1. In this case, the embedded structure 9 may be formed by wrapping the artificial device 3 with the side where the first container 1 of the sheet-shaped device container 8 is located on the inner surface side. In this case, it is desirable that the through hole 81 is provided at a substantially central portion of the sheet-like device housing 8. Then, the electric wire 42 of the electrode unit 4 penetrates so that the connector 41 is disposed on the side where the first housing 1 is located on the inner surface side and the electrode end 43 is disposed on the side where the second housing 2 is located on the outer surface side. It only has to pass through the hole 81.

(Modification 5)
In the above-described embodiment, it is the device container 8, that is, both the first container 1 and the second container 2, that are cut to put in and out the artificial device 3. If the 2 container 2 is not bonded in advance, only the second container 2 may be cut to insert and remove the artificial device 3. FIG. 8 is a conceptual diagram showing the structure of the artificial device 3 and the electrode unit 4 according to the fifth modification. An electric wire 32 for transmitting the generated electrical stimulation to the electrode unit 4 protrudes from the surface of the artificial device 3, and a connector 33 having an insertion port 31 is provided at the tip of the electric wire 32. The connector 41 of the electrode unit 4 is inserted into the insertion port 31 of the connector 33. Thereby, the electrical stimulation generated from the artificial device 3 is transmitted through the electric wire 32, the connector 33, the insertion port 31, the connector 41 and the electric wire 42, and is released from the electrode end 43 attached to the myocardium. As shown in the figure, the electric wire 32 of the artificial device 3 passes through the through hole 11 provided in the first container 1, and the electric wire 42 of the electrode unit 4 is provided in the second container 2. It penetrates through hole 21. And since it is the structure similar to the through-hole 81 mentioned above, a biological tissue does not approach from the outer surface side of each container through the through-hole 11 and the through-hole 22 to the inner surface side.

  FIG. 9 is a diagram showing an embedded structure 9 in which the artificial device 3 and the electrode unit 4 shown in FIG. 8 are accommodated in the first container 1 and the second container 2 in the fifth modification. As shown in FIG. 9 (a), the artificial device 3 enters the inner surface side of the first container 1 through the opening K1 of the first container 1, and the opening K1 is joined so that the first container is joined. The artificial device 3 is accommodated in 1. At this time, a connector 33 including an electric wire 32 and an insertion port 31 protrudes from the opposite side of the opening K1 of the first container 1. Then, the connector 41 inside the second container 2 is inserted into the insertion port 31 of the connector 33. Furthermore, the 1st container 1 which accommodated the artificial device 3 enters into the inner surface side of the 2nd container 2 through the opening part L1 of the 2nd container 2, and this opening part L1 joins and the 2nd container 2 accommodates the first container 1. FIG. 9B is a view showing a cross section of the embedded structure 9 formed as shown in FIG. In addition, the connector 33 provided with the electrode unit 4, the electric wire 32, and the insertion port 31 is abbreviate | omitted in the same figure. As shown in the figure, the joined opening K1 of the first container 1 is on the inner surface side of the joined opening L1 of the second container 2. Therefore, the first container 1 can be taken out from the second container 2 by incising only the second container 2 at the portion L2 between the opening K1 and the opening L1.

(Modification 6)
In the above-described embodiment, the electric wire 42 of the electrode unit 4 is directly passed through the through hole 81 provided in the device housing 8, but a member is inserted between the electric wire 42 and the through hole 81. May be. FIG. 10 is a diagram for explaining the sixth modification. As shown in FIG. 10A, the electric wire 42 passes through a through hole 821 provided in the cylindrical member 82, and the cylindrical member 82 passes through the through hole 81. FIG. 10B shows a cross-sectional view of the cylindrical member 82 cut off on the surface including the direction in which the electric wire 42 extends. Since the cylindrical member 82 is interposed between the through hole 81 and the electric wire 42 in this way, by selecting one of the plurality of cylindrical members 82, the electric wires 42 of various thicknesses are penetrated. It can be applied to the hole 81.
The cylindrical member 82 is preferably made of a material having an action of adhering to the first container 1. As a result, the outer peripheral surface of the cylindrical member 82 and the inner edge of the through-hole 81, particularly the inner edge of the through-hole 81 on the first container 1 side, are adhered to each other. This is because the possibility of entering is reduced. The cylindrical member 82 is preferably formed of a material that compresses when subjected to an external force. Even if this cylindrical member 82 is manufactured so that its outer periphery is larger than the inner periphery of the through hole 81, the cylindrical member 82 receives pressure from the inner edge of the through hole 81 by passing through the through hole 81. This is because the outer periphery of the cylindrical member 82 is in close contact with the through hole 81 by being compressed. Further, as shown in FIG. 10C, the cylindrical member 82 is provided with a portion that is gradually thickened in the axial direction and has a tapered shape, and a part of this tapered shape passes through the through hole 81. It is desirable that the thickness is not possible. By pushing this cylindrical member 82 into the through hole 81 in the direction in which the outer periphery decreases in the taper shape (the living body side in the figure), the gap between the cylindrical member 82 and the through hole 81 can be brought into close contact. This is because the possibility of the living tissue entering from the inside is reduced. Further, a spiral groove or screw may be provided on the side surface of the cylindrical member 82. In this case, the cylindrical member 82 is spirally rotated and penetrated through the through hole 81 so that the spiral groove or screw provided on the side surface of the cylindrical member 82 meshes with the inner surface side of the through hole 81 and is in close contact therewith. Therefore, the possibility that the living tissue enters from the gap is reduced.

(Modification 7)
In the above-described embodiment, a cardiac pacemaker is used as the artificial device 3, but the artificial device 3 may be another device. For example, an artificial kidney (an implantable dialysis device) or a drug administration device may be used. In this case, the communication device that connects the inner surface side and the outer surface side of the device housing 8 is not limited to the electrode unit 4. For example, a tube that draws blood into the artificial device 3 or a tube that administers a drug may be used. An electric wire or the like for investigating a living body may be used. In addition, only one such communication device is provided for each artificial device 3, and one artificial device 3 may use two or more communication devices. In this case, what is necessary is just to provide the through-hole according to the number of communication apparatuses in the apparatus accommodating body 8. FIG.

It is a conceptual diagram which shows the structure of the artificial device and electrode unit which concern on invention. It is a conceptual diagram which shows the structure of the embedded structure which concerns on this invention. It is a figure for demonstrating the internal structure of an embedding structure. It is a figure for demonstrating the extraction operation of the artificial device which concerns on the modification 1. FIG. It is a figure which shows the outline of the apparatus container which concerns on the modification 1. FIG. It is a conceptual diagram for demonstrating the modification 2. FIG. It is a figure explaining the mode of joining in modification 3. It is a conceptual diagram which shows the structure of the artificial device which concerns on the modification 5, and an electrode unit. It is a figure for demonstrating the modification 5. FIG. It is a figure for demonstrating the modification 6. FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... 1st container, 2 ... 2nd container, 2-1, 2-2, 2-3 ... layer, 3 ... Artificial device, 8 ... Device container, 9 ... Structure, K1 ... Opening part, L1 -L4 ... opening.

Claims (6)

A first anti-adhesion film having an action of preventing adhesion with a living body and having a first accommodating space for accommodating the artificial device, and a first hole penetrating the inside and outside of the first accommodating space. A containing body;
A second accommodation space formed of an adhesion film having an action of adhering to a living body, and having a second accommodation space for accommodating the first accommodation body and a second hole penetrating the inside and outside of the second accommodation space. A device container comprising: a container. The hollow cylindrical member inserted into the second hole, the outer peripheral surface comprising a cylindrical member having an action of adhering to the inner edge of the second hole. Device enclosure. The cylindrical member is compressed by receiving pressure from an inner edge of the second hole in a state of being inserted into the second hole, and is in close contact with the second hole. The device container according to 1. The cylindrical member is provided with a portion that is gradually thickened in the axial direction and has a tapered shape, and a portion of the tapered shape has a thickness that cannot pass through the second hole. The device container according to claim 2, wherein the device container is a device container. The adhesion film forming the second container has a thickness of a peripheral portion of the second hole larger than a thickness of a portion other than the peripheral portion. The device container according to 1. An anti-adhesion sheet having an action of preventing adhesion with a living body and having a hole penetrating the front and back of the own sheet;
Adhesion having a function of adhering to a living body, bonded to one surface of the anti-adhesion sheet, and provided with a hole penetrating the front and back of the sheet at a position overlapping with a hole provided in the anti-adhesion sheet A biomedical sheet comprising: a sheet.

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