JP2010054232A - Reaction card and automatic analyzing apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a reaction card capable of shortening the analyzing time of a specimen in reexamination, and to provide an automatic analyzing apparatus. <P>SOLUTION: The automatic analyzing apparatus includes the reaction card 5 having a plurality of reaction containers 52 dispensing the specimen and a reagent to perform immunological agglutination reaction and a specimen housing container 51 housing the preparatory specimen dispensed in the respective reaction containers and a card keeping part 39 for temporarily keeping the reaction card becoming a reexamination target on the basis of an analyzing result. In the case of the reexamination, the specimen housed in the specimen housing container 51 of the reaction card 5 temporarily kept in the card keeping part 39 is used to perform analysis without rearranging the specimen being the reexamination target to the analyzing apparatus. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a reaction card for performing an immunological agglutination reaction and an automatic analyzer.

  Conventionally, in an analysis method for immunologically analyzing a sample such as plasma, blood cells, or serum, a reagent corresponding to the test content is mixed with the sample in a reaction container in a dedicated reaction card and reacted. After incubation, the presence or absence of agglutination is confirmed from the reaction image generated by centrifuging the reaction card with a centrifuge. The sample is negative for antibody or antigen based on the agglutination pattern of the sample and reagent. It is determined whether it is positive or not (for example, see Patent Documents 1 and 2).

  In addition, the above-mentioned reaction card performs negative or positive determination based on an agglutination pattern by an antigen or antibody to perform ABO blood group determination, and antibodies other than regular antibodies such as anti-A antibody and anti-B antibody (non-antibodies) Regular antibody), it is possible to determine the Rh blood group from the agglutination pattern by the erythrocyte membrane antigen and the presence or absence of an irregular antibody by the erythrocyte antigen. In particular, in blood transfusion, the accuracy of examination is important in order to prevent blood aggregation or hemolysis.

  In the method of identifying an antigen or antibody in blood using a reaction card, when performing ABO blood type determination, each agglutination reaction of anti-A serum, anti-B serum, type A red blood cell, and type B red blood cell with respect to a specimen It is analyzed separately according to the presence or absence of. An anti-A serum and an anti-B serum were used to perform a front test for analysis from the blood cell side, and a back test for analysis from the serum side using type A red blood cells and type B red blood cells. The ABO blood group is determined by determining whether or not it has the B antigen and the anti-A antibody and / or the anti-B antibody, and confirming the correlation between the front test and the back test. Here, if there is no correlation between the front test and the back test, the blood type cannot be determined, so a retest is performed. In addition, anti-D antibody, which is one of irregular antibodies, against anti-A antibody and anti-B antibody is an antibody that greatly affects aggregation or hemolysis among Rh blood groups. It is important to confirm the presence or absence of blood transfusion. The blood type used for blood transfusion is determined from these determination results.

  In addition to the antibodies described above, it has been found that many types of antibodies exist and may exist in the blood of the specimen. In particular, if there is a risk of hemolytic transfusion side effects or neonatal hemolytic disease due to maternal blood type incompatibility, check if there is an irregular antibody in the sample, and if there is an irregular antibody Need to identify and respond to irregular antibodies. In the method for confirming irregular antibodies, first, irregular antibody screening is performed by using an antibody screening blood cell reagent to confirm the presence or absence of irregular antibodies in the serum or plasma of a specimen by antigen-antibody reaction. If the determination result by the irregular antibody screening is positive, re-examination is performed using an identification blood cell reagent to identify the irregular antibody.

  By the way, conventionally, the above-described analysis may be automatically performed using an analyzer. By using the analysis device, the analysis accuracy can be improved and more reliable data can be obtained.

JP 2007-322238 A JP-A-8-7215

  However, in the case of re-examination of the sample, such as when the irregular antibody screening is positive and the irregular antibody is identified in the analyzer, the analyst places the sample container of the sample in the sample rack again for analysis. This relocation operation required time and effort to perform the analysis process.

  The present invention has been made in view of the above, and an object of the present invention is to provide a reaction card and an automatic analyzer that can shorten the analysis time of a sample in a retest.

  In order to solve the above-described problems and achieve the object, the reaction card according to the present invention is provided with a plurality of reaction containers in which a specimen and a reagent are dispensed to perform an immunological agglutination reaction, and each reaction container is dispensed. And a storage container for storing a spare specimen or a spare diluted specimen.

  The reaction card according to the present invention is characterized in that, in the above invention, a plurality of the storage containers are provided corresponding to each reaction container, and are arranged adjacent to each reaction container.

  Further, the automatic analyzer according to the present invention is the above-described invention, wherein a plurality of reaction containers for dispensing an analyte and a reagent to perform an immunological agglutination reaction and spare samples dispensed in each reaction container A reaction card having a storage container for storing a spare diluted sample, a sample transport mechanism for transporting the sample, a reagent dispensing means for dispensing the reagent into each reaction container, and each of the sample or the diluted sample. A sample dispensing means for dispensing the sample or diluted sample as a spare sample in the container and a plurality of the reaction cards, and a reaction card in which the reagent and the sample are dispensed A reaction means for performing an immunological agglutination reaction, an analysis means for analyzing the sample based on a result of the immunological agglutination reaction performed by the reaction means, and a reexamination based on an analysis result of the analysis means Subject A card storage unit for temporarily storing the reaction card and a reaction card to be retested when there is a reaction card to be retested, and dispensing the spare sample stored in the reaction card Re-examination control means for analyzing the specimen, and re-examination for dispensing the specimen of the reaction card accommodation container accommodated in the card accommodation section into each reaction container of the reaction card newly accommodated in the reaction means And a sample dispensing means.

  Moreover, the automatic analyzer according to the present invention is characterized in that, in the above invention, a plurality of containers for the reaction card are provided corresponding to each reaction container and are arranged adjacent to each reaction container.

  The automatic analyzer according to the present invention may further include a transport unit that transports the reaction card to be retested stored in the card housing unit to the reaction unit in the above invention, and the retest sample dispensing unit includes: The sample dispensing means.

  The automatic analyzer according to the present invention further comprises a sample dilution means for diluting the sample in the above invention, and the diluted sample stored in the storage container and the reaction container is diluted by the sample dilution means. It is characterized by being a specimen.

  In the automatic analyzer according to the present invention as set forth in the invention described above, the analysis means is a retest object including an irregular antibody identification test or a reanalysis test based on the reaction result of the immunological agglutination reaction. It is characterized by determining the reaction card.

  According to the present invention, since the storage container for storing the spare sample to be dispensed in each reaction container of the reaction card is provided, the analysis can be continued without re-positioning the sample container at a predetermined position even when retesting is performed. As a result, the analysis time of the specimen can be shortened.

  Hereinafter, an automatic analyzer according to an embodiment of the present invention will be described with reference to the drawings. Note that the present invention is not limited to the embodiments. In the description of the drawings, the same parts are denoted by the same reference numerals. Note that the drawings referred to in the following description are schematic, and when the same object is shown in different drawings, dimensions, scales, and the like may be different.

  Embodiments of the present invention will be described below with reference to the accompanying drawings. FIG. 1 is a plan view showing a schematic configuration of an automatic analyzer 1 according to an embodiment of the present invention. The automatic analyzer 1 includes a transport mechanism 2 that transports a specimen, a measurement mechanism 3 that dispenses a specimen and a reagent into a reaction container 52, and optically measures a reaction that occurs in the dispensed reaction container 52; A control mechanism 4 that controls the entire automatic analyzer 1 including the mechanism 2 and the measurement mechanism 3 and analyzes the measurement result in the measurement mechanism 3 is provided.

  The sample transport mechanism 2 holds a sample rack 22 in which the sample containers 21 are arranged, has a caterpillar 23 having an L-shaped attachment orthogonal to the transport direction, and the analysis mechanism 3, FIG. 1 includes a transport lane 25 that transports the sample rack to the left carry-out lane, and a rack step claw 24 that is disposed on the transport lane 25 and moves on the transport lane 25 to transport the sample rack 22, not shown. The sample rack 22 is transported in the direction of the arrow in the figure by the drive mechanism. Also, a barcode is affixed to the sample container 21, and the sample information can be managed by reading it with a barcode reader (not shown).

  The measuring mechanism 3 is roughly divided into a reagent store 30, a reagent dispensing mechanism 31, a reaction table 32, a card transfer mechanism 33, 37, a card outlet 34, a sample dispensing mechanism 35, a diluent bottle 36, an imaging unit 38, and a card storage. The unit 39 is provided. The control mechanism 4 includes a control unit 41, an input unit 43, an analysis unit 44, a storage unit 45, and an output unit 46. These units included in the measurement mechanism 3 and the control mechanism 4 are electrically connected to the control unit 41.

  The reagent storage 30 can store a plurality of reagent containers 30 a in which reagents to be dispensed in the reaction container 52 are stored. In the reagent storage 30, a plurality of storage chambers are arranged at equal intervals, and a reagent container 30a is detachably stored in each storage chamber. The reagent storage 30 can be rotated clockwise or counterclockwise about a vertical line passing through the center of the reagent storage 30 as a rotation axis by driving a drive mechanism (not shown) under the control of the control unit 41. The desired reagent container 30a is transferred to the reagent suction position by the reagent dispensing mechanism 31. An openable / closable lid (not shown) is provided above the reagent storage 30 to suppress the evaporation, denaturation, and contamination of the reagent.

  The reagent dispensing mechanism 31 includes an arm that freely moves up and down in the vertical direction and rotates around a vertical line passing through the base end of the reagent dispensing mechanism 31 as a central axis. A probe for aspirating and discharging the specimen is attached to the tip of the arm. The reagent dispensing mechanism 31 sucks the reagent in the reagent container 30a moved to a predetermined position on the reagent storage 30 with a probe, rotates the arm around an arrow in the figure, and is transported to a predetermined position on the reaction table 32. Into the reaction vessel 52.

  In the reaction table 32, the reaction card 5 for dispensing the sample and the reagent into the reaction container 52 is arranged in a card holding unit provided at a predetermined position. The reaction table 32 is rotatable about a vertical line passing through the center of the reaction table 32 as a rotation axis when driven by a drive mechanism (not shown) under the control of the control unit 41. An openable / closable lid and a thermostat (not shown) are provided above and below the reaction table 32, respectively. In the reaction table 32, the sample and the reagent are dispensed, and the sample and the reagent are reacted by incubation at a predetermined temperature and a predetermined time, and then the reaction table 32 is rotated by a drive mechanism (not shown). The reaction card 5 is driven and rotated, and a centrifugal force is applied to separate the reaction solution in which the sample and the reagent contained in the reaction container 52 have reacted. Here, the card holding portion of the reaction table 32 is a columnar member extending in the radial direction of the reaction table 32, and has an opening in the upper end plane, and the reaction card 5 in an internal space formed in the vertical direction from the opening. Hold. Moreover, a hole for attaching a rotation shaft of the card holding portion is provided on a side surface of the card holding portion that is substantially parallel to the radial direction of the reaction table 32, and the reaction table 32 and the card holding portion are contacted by the rotation shaft. is doing. The card holding unit rotates around the rotation axis by the centrifugal force applied by the rotation of the reaction table 32. The reaction card 5 receives a centrifugal force generated by the rotation of the reaction table 32 from the card holding unit, receives a force directed downward of the reaction card, and attracts the reaction liquid contained in the reaction container downward of the card.

  The card transfer mechanism 33 includes an arm that freely moves up and down in the vertical direction and rotates around a vertical line passing through the base end of the card transfer mechanism 33 as a central axis. A tip of the arm has a card holding arm for holding the reaction card 5, and the reaction card 5 prepared in the card outlet 34 is transferred to the reaction table 32.

  The card outlet 34 has a card storage below the outlet, and a reaction card necessary for analysis is placed in the card outlet 34 under the control of the control unit 41.

  Similar to the reagent dispensing mechanism 31, the sample dispensing mechanism 35 includes an arm having a probe attached to the distal end portion for aspirating and discharging the sample. The arm freely moves up and down in the vertical direction and rotates around the vertical line passing through its base end as a central axis. In the vicinity of the specimen dispensing mechanism 35, a cleaning pod 35a and a dilution pod 35b are provided. In the dilution pod 35b, the sample is sucked by the probe from the sample container 21 transported to a predetermined position on the sample transport mechanism 2 described above, the arm is turned, and the sample is discharged into the dilution pod 35b. It is diluted with a diluent contained in 36. The diluent bottle 36 has a tube extending from above to the outside, communicates with the dilution pod 35b, and sends the diluent into the dilution pod 35b by a pump or a syringe (not shown). The sample dispensing mechanism 35 sucks the sample or the sample diluted with the dilution pod 35b, and discharges the sample into the reaction container 52 to perform dispensing. Further, the probe is appropriately cleaned with the cleaning pod 35a.

  The imaging unit 38 measures the sample in the reaction container 52 of the reaction card 5 that has been transported to a predetermined imaging position by the card transfer mechanism 37. The measurement result by the imaging unit 38 is output to the control unit 41 and analyzed by the analysis unit 44. Further, the reaction card 5 that is no longer required to be reinspected according to the analysis result is discarded in the card discarding unit 38a. If re-inspection is necessary according to the analysis result, the card is transferred to the card storage unit 39 by the card transfer mechanism 37.

  The reaction card 5 includes a sample container 51 for storing a spare sample, a reaction container 52 for performing a reaction by dispensing the reagent and the sample, and separating a reaction solution in which the reagent and the sample are reacted by centrifugation. Have The sample storage container 51 stores the same sample as the sample dispensed in the reaction container 52 of the reaction card 5 which is a sample or a sample diluted with the dilution pod 35b.

  Next, the control mechanism 4 will be described. The control unit 41 is configured using a CPU or the like, and controls processing and operation of each unit of the automatic analyzer 1. The control unit 41 performs predetermined input / output control on information input / output to / from each of these components, and performs predetermined information processing on this information. In addition, the control unit 41 includes a reinspection control unit 42. The reexamination control unit 42 issues an instruction to the measurement mechanism 3 when the reexamination instruction is issued from the control unit 41, and performs reexamination analysis control.

  The input unit 43 is configured using a keyboard, a mouse, a communication function, and the like, and acquires various information necessary for analyzing the sample, instruction information for analysis operation, and the like from the outside. The analysis unit 44 performs processing based on the image data acquired from the imaging unit 38 and analyzes the sample. The storage unit 45 is configured by using a hard disk that magnetically stores information and a memory that loads various programs related to the process from the hard disk and stores them electrically when the automatic analyzer 1 executes the process. Various information including the analysis result of the specimen is stored. The storage unit 45 may include an auxiliary storage device that can read information stored in a storage medium such as a CD-ROM, a DVD-ROM, or a PC card. The output unit 46 is configured using a printer, a communication mechanism, and the like, and outputs various information including the analysis result of the sample.

  In the automatic analyzer 1 configured as described above, the specimen dispensing mechanism 35 dispenses the specimen or the diluted specimen in the dilution pod 35b to the plurality of reaction cards 5, and the reagent dispensing mechanism 31 After dispensing the reagent in the reagent container 30a, the imaging unit 38 performs an imaging process in a state where the reaction solution obtained by the reaction between the sample and the reagent is separated by centrifugation, and the analysis unit 44 analyzes the imaging data. Thus, the analysis of the specimen is automatically performed.

  Next, the reaction card 5 according to the embodiment of the present invention will be described with reference to FIG. FIG. 2 is a perspective view schematically showing the reaction card 5. The reaction card 5 includes a card-shaped main body 50, a sample storage container 51 and a reaction container 52 having an opening in the upper flat surface of the main body 50, and an identification barcode 53 attached to the main body 50. Have.

  The sample storage container 51 has a substantially cylindrical shape, and has a bottom formed in a substantially conical shape. A sample or a sample diluted with the dilution pod 35 b is dispensed by the sample dispensing mechanism 35. The reaction vessel 52 has a substantially cylindrical shape and is provided in communication with a reaction part 521 for reacting a specimen and a reagent, and a bottom part of the reaction part 521, and a reaction for determining the presence or absence of aggregation according to the result of the reaction. A separation unit 522 holds gel or glass beads as a carrier for generating an image, and holds a solution obtained by centrifuging an antigen-antibody reaction between a specimen and a reagent by a centrifuge. The reaction card 5 is formed using a translucent resin. For analysis, each reagent is dispensed to each reaction unit 521, one sample is dispensed to each reaction unit 521 on one reaction card, and the same sample is accommodated in the sample storage container 51.

  Here, the analysis process in the irregular antibody screening will be described with reference to FIG. FIG. 3 is a flowchart showing an analysis process of irregular antibody screening in the control unit 41.

  When the control unit 41 receives an instruction for irregular antibody screening, a barcode reader (not shown) first reads the barcode of the sample and the reaction card 5 and stores information corresponding to the sample and the reaction card 5 in the storage unit 45. The reaction card 5 is placed on the reaction table 32 (step S102). The control unit 41 instructs the sample dispensing mechanism 35 to dispense the sample respectively to the reaction container 52 and the sample storage container 51 of the reaction card 5 corresponding to the barcode information, and the reagent dispensing mechanism 31 performs the analysis. Necessary reagents are dispensed into each reaction container 52 (step S104). When the dispensing of the sample and the reagent into the reaction container 52 is completed, the control unit 41 causes the sample and the reagent stored in the reaction container 52 to incubate in the reaction table 32 for a predetermined temperature and for a predetermined time, and then centrifuges after the predetermined time has elapsed. Processing is performed to separate the mixed liquid of the specimen and the reagent into the carrier of the separation unit 522 of the reaction container 52 (step S106). Thereafter, the control unit 41 performs imaging processing on the aggregated image separated by the separating unit 522 by the imaging unit 38 (step S108), and instructs the analysis unit 44 to analyze the aggregated image obtained by the imaging processing (step S108). S110). The analysis unit 44 determines whether or not the irregular antibody is positive from the aggregated image obtained by the imaging unit 38 (step S112). When the analysis result output from the analysis unit 44 is positive for the irregular antibody (step S112: Yes), the control unit 41 transfers the reaction card to the card storage unit 39 (step S114). The reaction card 5 temporarily stored in the card storage unit 39 is then used for reinspection processing (step S116). When there is an instruction to analyze the next sample (step S118: Yes), the control unit 41 proceeds to step S102 and performs sample analysis processing. If there is no analysis instruction for the next sample (step S118: No), the analysis process is terminated. In step S112, if the irregular antibody is negative (step S112: No), the reaction card is discarded in the card discard unit 38a, and the process proceeds to step S118 to check whether there is an instruction to analyze the next sample.

  Next, a retest for identifying an irregular antibody when the irregular antibody is positive will be described with reference to FIG. FIG. 4 is a flowchart showing the re-inspection process in step S116 of FIG.

  When receiving a reinspection instruction from the control unit 41, the reinspection control unit 42 first reads the barcode of the reaction card 5 to be reinspected (step S202). The read card information and the reaction card information for identifying the irregular antibody are associated with each other, and the reinspection control unit 42 transfers the reaction card 5 to be reinspected from the card storage unit 39 to the reaction table 32 by the card transfer mechanism 37. Transfer (step S204). The reexamination control unit 42 issues an instruction to dispense the sample stored in the sample storage container 51 of the reaction card 5 to be reexamined into each reaction container of the reaction card for irregular antibody identification ( Step S206). Thereafter, the reexamination control unit 42 dispenses reagents necessary for analysis into each reaction container of the reaction card for identifying irregular antibodies (step S208), performs incubation and centrifugation, and executes the specimen, reagent, The reaction and separation are performed (step S210). The imaging unit 38 captures the aggregated image obtained by the separation (step S212), and the analysis unit 44 analyzes whether or not all the identification reagents are positive (step S214). Thereafter, the process returns to step S116.

  Here, the barcode of the reaction card 5 used for the re-examination may be read by the imaging unit 38, or a barcode reader may be installed in the card storage unit 39. The reaction card for identifying irregular antibodies may be a card in which the specimen storage container 51 is not arranged.

  The re-inspection process can be applied to any re-inspection in the analysis process in addition to the identification inspection by irregular antibody screening.

  Here, a modification of the reaction card shown in FIG. 2 will be described with reference to FIG. As shown in FIG. 5, the reaction card 5 has a plurality of specimen storage containers 51 arranged adjacent to each reaction container 52. In the analysis method using a reaction card, antibody screening, which is originally performed by preparing several blood cell reagents containing several kinds of antigens and dispensing them in each reaction part 521, is performed on one reaction part 521. It is also possible to perform antibody screening by dispensing a blood cell reagent for antibody screening. In this case, antibody screening of a plurality of specimens is performed for one reaction card. By arranging a plurality of specimen storage containers 51 adjacent to each reaction container 52, when an irregular antibody test becomes positive, a single reaction card is held and a plurality of specimens such as an antibody identification test are performed. It becomes possible to cope with re-examination.

  A modification of the automatic analyzer shown in FIG. 1 will be described with reference to FIG. In the automatic analyzer 1 shown in FIG. 6, the sample dispensing mechanism 35 is disposed in the vicinity of the card storage unit 39 and dispenses the sample container 21 and the sample stored in the sample storage container 51 of the reaction card 5. By disposing the sample dispensing mechanism 35 in the vicinity of the card storage unit 39, when a retest is performed, the reaction card to be retested stored in the card storage unit 39 is transferred to the reaction table 32 by the card transfer mechanism 37. The sample stored in the sample storage container 51 can be dispensed into a new reaction card without any problem. When the sample of the reaction card 5 stored in the card storage unit 39 is dispensed by the sample dispensing mechanism 35, the card transfer mechanism 37 reacts so that the sample storage unit 51 is arranged at the position P in the figure. By transporting the card 5, the sample dispensing mechanism 35 can be aspirated. Here, the position P is the intersection of the probe trajectory of the sample dispensing mechanism 35 and the trajectory of the sample storage unit 51 of the reaction card 5 by the card transfer mechanism 37.

  In the present embodiment, when a retest is performed by providing a sample storage container on the reaction card and storing the diluted sample, it is not necessary to place the sample container again in the analyzer, and the time required for the analysis process Can be shortened, and the labor required for the analyst can be reduced. In addition, since the automatic re-inspection function can be provided without incorporating a mechanism for transporting the rack to the transport mechanism again, the apparatus configuration can be simplified.

It is a top view which shows schematic structure of the automatic analyzer concerning embodiment of this invention. It is a perspective view which shows the reaction card concerning FIG. It is a flowchart which shows the analysis process of irregular antibody screening. It is a flowchart which shows the reexamination process in step S116 of FIG. It is a perspective view which shows the modification of the reaction card shown in FIG. It is a top view which shows the modification of the automatic analyzer shown in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Automatic analyzer 2 Transport mechanism 3 Measurement mechanism 4 Control mechanism 5 Reaction card 21 Sample container 22 Sample rack 23 Caterpillar 24 Rack advance claw 25 Transport lane 30 Reagent storage 30a Reagent container 31 Reagent dispensing part 32 Reaction table 33, 37 card Transport mechanism 34 Card outlet 35 Sample dispensing mechanism 36 Diluent bottle 38 Imaging unit 39 Card storage unit 41 Control unit 42 Reexamination control unit 43 Input unit 44 Analysis unit 45 Storage unit 46 Output unit 50 Main unit 51 Sample storage container 52 Reaction vessel 521 Reaction unit 522 Separation unit

Claims (7)

  A plurality of reaction containers in which specimens and reagents are dispensed to perform an immunological agglutination reaction and a storage container for storing spare specimens or spare diluted specimens to be dispensed in each reaction container And a reaction card.   2. The reaction card according to claim 1, wherein a plurality of the storage containers are provided corresponding to each reaction container, and are disposed adjacent to each reaction container. A reaction card having a plurality of reaction containers for dispensing specimens and reagents to perform an immunological agglutination reaction, and a storage container for storing spare specimens or spare diluted specimens to be dispensed in each reaction container; ,
A sample transport mechanism for transporting the sample;
Reagent dispensing means for dispensing the reagent into each reaction container;
Sample dispensing means for dispensing the sample or diluted sample into each reaction container and dispensing the sample or diluted sample as a spare sample in the storage container;
A reaction means for accommodating a plurality of the reaction cards, and performing an immunological agglutination reaction of the reaction card in which the reagent and the sample are dispensed;
Analysis means for analyzing the specimen based on the result of the immunological aggregation reaction performed by the reaction means;
A card storage section for temporarily storing a reaction card that has been subject to re-examination according to the analysis result of the analysis means;
Reexamination control means for transporting the reexamination target card when there is a reaction card as the reexamination target, dispensing the spare sample contained in the reaction card, and analyzing the specimen;
Re-examination sample dispensing means for dispensing the sample of the reaction card container contained in the card container to each reaction container of the reaction card newly accommodated in the reaction means;
An automatic analyzer characterized by comprising:   4. The automatic analyzer according to claim 3, wherein a plurality of containers for the reaction card are provided corresponding to each reaction container and are arranged adjacent to each reaction container.   4. A transport unit that transports a reaction card to be retested stored in the card storage unit to the reaction unit, wherein the retest sample dispensing unit is the sample dispensing unit. Or the automatic analyzer of 4. A sample dilution means for diluting the sample,
The automatic analyzer according to any one of claims 3 to 5, wherein the diluted sample stored in the storage container and the reaction container is a sample diluted by the sample dilution means.   The analysis means determines a reaction card as a retest target including an irregular antibody identification test or a reanalysis test based on a reaction result of the immunological agglutination reaction. The automatic analyzer as described in any one of.

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