JP2010051562A - Method and apparatus for stimulating depth of living body - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method and an apparatus for electrically stimulating the target region of the depth of a living body by indwelling a small open circuit coil inside a body and generating an inductive voltage in the indwelling coil by a pulse magnetic field to be given from an extracorporeal magnet-exciting coil. <P>SOLUTION: The method for stimulating the depth of the living body is characterized by indwelling the open circuit coil in a region to be electrically stimulated inside the living body, generating the pulse magnetic field from the magnet-exciting coil arranged at the outside the body, and electrically stimulating a very small region inside the body through the indwelling coil by the electromotive force. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a living body deep stimulation method and a living body deep stimulation apparatus in which an indwelling type electrode is disposed in a body and an electrical stimulation is applied to the inside of a living body by an induced electromotive force generated by an external magnetic field to diagnose and treat a disease.

Transcranial magnetic stimulation is based on the law of magnetic induction discovered by Faraday. When a current flows through the coil, a magnetic field is simultaneously generated vertically, and a secondary current is generated in the brain by the magnetic field. This very small amount of current is used to stimulate brain cells. Although generally referred to as magnetic stimulation, it is actually weak electrical stimulation (referred to as “magnetic stimulation” in this specification).
For example, when the motor area of the brain receives this magnetic stimulation, the secondary current can stimulate the cells of the motor area to move the feet and fingers. In the treatment, it is said that the brain of a depression patient can be stimulated to activate the brain.

For these reasons, recently, there is a strong interest in transcranial magnetic stimulation (TMS) for diagnosing and treating diseases. However, as the current technology for transcranial magnetic stimulation, an O-shaped coil or an 8-shaped coil is exclusively used, but the depth at which magnetic stimulation can be performed is in a shallow portion of about 1 to 2 cm from the brain surface. limited. Therefore, it cannot be said that there are facilities that can be used for effective diagnosis and treatment of the deep brain.
According to the following Non-Patent Document 1 and Non-Patent Document 2, the target of transcranial magnetic stimulation is limited to the cerebral cortex having a depth of 2 cm or less from the scalp. These restrictions are caused by the fact that the magnetic field generated by the coil is attenuated rapidly with distance, so that it is difficult to reach a strong magnetic flux to the deep part.

  When a known patent document is viewed, a magnetic stimulation apparatus is disclosed in which a converging magnetic field is obtained by cutting a part of an O-type magnetic core, thinning an opposing part, and winding a coil therearound (see Patent Document 1). . This technique is a device for stimulating excitable ecological tissues such as nerves or muscles of a living body, and strengthens the magnetic field in the vicinity of the magnetic pole surface by making the magnetic pole tip thinner. Moreover, even if it says that heat_generation | fever is suppressed, it is accompanied by heat_generation | fever not a little, and it cannot apply to the apparatus for transcranial deep part magnetic stimulation.

  As an improved version of Patent Document 1, a magnetic stimulation device is disclosed in which a magnetic material is disposed in a space formed inside a winding (see Patent Document 2). The effect of deforming the shape of the tip of the magnetic pole into a concave or convex shape and making the tip of the magnetic pole narrower is shown, but the magnetic field near the surface of the magnetic pole becomes stronger by making it thinner, but the reach distance is hardly changed. This is also a device for stimulating excitable ecological tissues such as nerves or muscles of a living body as in Patent Document 1, and has the same problem as described above, and is a device for transcranial deep magnetic stimulation. It is not applicable.

A living body magnetic stimulation device is disclosed in which coils arranged in a matrix are switched by computer control to change a place where a magnetic field is strong (see Patent Document 3). However, this technique is aimed at the surface and is not a technique for reaching the deep part.
In addition, a transcranial magnetic stimulation technique is described in which a coil is wound around a high-permeability semicircle to a horseshoe-shaped magnetic core to reduce heat generation of the coil and perform magnetic stimulation of the brain (see Patent Document 4). In this case, although the reach distance of the magnetic field has increased to 30 mm or more, there is a problem that the brain surface is naturally exposed to a strong magnetic field.

Since the exciting pulse current is high frequency, only the coil surface flows, and there is a problem that even if a thick wire is used, the electric resistance increases. In order to prevent this, it has been proposed to bundle a thin litz wire, which is a conventional means of a high-frequency coil, and wind the coil (see Patent Document 5). Again, the treatment target is a disorder of the lower back and blood flow, and it cannot be applied to a device for transcranial magnetic stimulation.
Furthermore, a coil for magnetic stimulation and a method using the same are disclosed (see Patent Document 6). This technology describes the deep brain, cardiovascular, etc., and places a triangular prism type coil on the head, showing its fine shape. However, this technique is not a deep stimulation, and each coil is not individually controlled. Therefore, it cannot be said that this technique has a sufficient function as a transcranial deep magnetic stimulation apparatus.

As described above, the present inventors previously arranged a loop coil array in which a plurality of loop coils serving as a magnetic field source are assembled, or a permanent magnet or a magnetic core, and based on numerical analysis, Calculate the magnetic action between them, and from this result, select the loop coil, the shape and arrangement of the permanent magnet and the magnetic core, and determine the magnitude and direction of the current flowing through the loop core, and the desired distribution and strength. There has been proposed a technique for obtaining a magnetic field, that is, a magnetic field generator that generates a convergent magnetic field by synthesizing the magnetic fields generated by a large number of coils (see Patent Document 7).
This technique is effective for effective diagnosis and treatment of the deep brain, but requires many tests and has a problem that the device is somewhat complicated.
The indirect magnetic stimulation method described above is relatively effective for the surface layer, but is not effective for deep stimulation.

On the other hand, there is a type in which an electrode, a battery, and a control device are embedded in the body. Deep brain stimulation (DBS) was conceived by Limozan, France, around 1995. It has various brain diseases such as severe depression, tremor caused by Parkinson's disease, obsessive compulsive disorder, and epilepsy. It is used for treatment. In addition, spinal cord stimulation therapy is used to treat severe pain (refractory chronic pain) due to nerve damage or compression and for which there is no other appropriate treatment.

These include, for example, Parkinson's disease, the hypothalamus nucleus in the deep brain, the thalamus in tremor, and the like. The operation is controlled by connecting with an electric wire passing through.

In addition, proposals have been made on electrodes for puncturing the affected part of the brain, methods for applying stimuli to implant-type electrodes by external lines, implantable probes, and the like (see Patent Documents 8, 9, 10, and 11).
Such an affected part stimulation method is effective because it is a direct method, but there is a problem that an apparatus for performing stimulation needs to be arranged in the vicinity of the affected part. This is a big burden for patients. In addition, the electrode may be exposed, and there is a problem that re-operation is required when replacing the electrode or device.

  For example, the current deep brain stimulation method uses an electric wire to connect an electrode and a battery / control device. However, in order to install this, a long operation is required. In addition, since the device used for such deep brain stimulation is generally fixed with a transmitter and a battery embedded in the chest, an operation for passing an electric wire from the top of the head to the chest is necessary. When the life span (usually 5 years) needs to be replaced due to a failure, re-operation is required each time. Further, the deep brain stimulation control device embedded in the chest has a problem that electronic devices such as mobile phones cannot be used nearby.

From the above, it cannot be said that any conventional indwelling stimulation method for living body or non-indwelling type or semi-indwelling stimulation method has a sufficient function as a deep body stimulation method.
Special Feature / Brain Function Test Manual, “Transcranial Magnetic Stimulation” by Arita, MB Med Reha No. 40: 17-26, 2004 Special Feature: Brain Function Test Manual, Nakanishi, Goto, “Transcranial Magnetic Stimulation-Related F Wave”, MB Med Reha No. 40: 27-35, 2004 JP-A-7-171220 JP-A-8-52231 JP-A-8-280820 Published Patent Publication 2000-504966 JP 2002-306614 A JP 2004-511314 A JP 2006-255314 A JP 2007-325652 A Special Table 2007-515200 Special table 2008-508984 gazette Special table 2008-513082 gazette

  Electrical stimulation therapy that stimulates only a desired minute part with electrodes embedded in the brain or spinal cord has a problem that it is necessary to fix a pulse transmitter, a power source, and a controller in the body. The present invention provides a method and an apparatus in which a small open circuit coil is placed in the body and an induced voltage is generated in the placed coil by a pulsed magnetic field generated by an excitation coil outside the body, thereby electrically stimulating a target site in the deep part of the living body. To do.

In order to solve the above problems, the present invention provides the following living body deep part stimulation method.
1) An inductive electromotive force is generated in the indwelling coil by generating an inductive electromotive force in the indwelling coil by generating an inductive electromotive force coil from an exciting coil placed outside the body while injecting an open circuit coil inside a living body. A deep body stimulation method characterized by electrically stimulating a minute part in the body through the indwelling coil

  2) Indwelling a plurality of open circuit coils having different axial directions in a site to be electrically stimulated inside a living body, and generating a pulsed magnetic field from an excitation coil installed outside the body with respect to the indwelling coil. In addition to generating an induced electromotive force, the axial direction of the magnetic field of the excitation coil installed outside the body is changed, and an effective induced electromotive force is generated only in the indwelling coil having the same direction, and a minute part in the body is electrically For stimulating deep part of living body

3) Insulating the winding portion of the indwelling coil, exposing the tip portion of the winding drawn from the indwelling coil, and electrically stimulating a minute part in the body through the tip portion ) Or 2) Living body deep part stimulation method 4) Resonating coil and capacitor are combined to form a resonance circuit, and the inductive coil induced voltage is increased by an external magnetic field to electrically stimulate a minute part in the body. The living body deep stimulation method according to any one of 1) to 3) above,

The present invention also provides the following deep body stimulation apparatus.
5) An open circuit coil placed at a site for electrical stimulation inside the living body and an excitation coil installed outside the body for generating an induced electromotive force in the placement coil, and generating a pulsed magnetic field from the excitation coil And generating an induced electromotive force in the indwelling coil and electrically stimulating a minute part in the body through the indwelling coil by the electromotive force.

  6) A plurality of open-circuit indwelling coils with different axial directions placed in a portion to be electrically stimulated inside the living body, and an excitation coil installed outside the body for generating a pulsed magnetic field in the indwelling coil. A living body characterized in that a pulsed magnetic field is generated from a coil and the axial direction of the magnetic field is changed to generate an induced electromotive force effective only in a coil having the same direction to electrically stimulate a minute part in the body. Deep stimulator

7) It has a wound portion of the indwelling coil that is insulation-coated, and an exposed portion of the winding tip that is drawn out from the indwelling coil, and electrically stimulates a minute part in the body through the exposed portion of the tip. 5) or 6) the deep body stimulating device described in 8) above, and 8) a combination of an indwelling coil and a capacitor to form a resonance circuit for increasing the inductive coil induced voltage by an external magnetic field. The stimulating device for a deep part of a living body according to any one of 5) to 7) above, wherein the stimulating device is electrically stimulated.

  The living body deep portion stimulation method and the living body deep portion stimulation apparatus of the present invention have an effect that the burden on the patient can be greatly reduced because only the coil having a size of soybean is placed in the body. Further, unlike the conventional case, since it is not necessary to connect the electrode and the battery / control device with an electric wire, the coil can be implanted in the affected area by a relatively short operation. In addition, since there is no need to embed batteries, transmitters, wires, etc. in the body, it is possible to reduce the number of reoperations for replacement of these devices, corresponding to the life of the batteries, reducing the failure of the devices. it can. Since the indwelling coil of the present invention does not produce a stimulating effect other than the pulsed magnetic field, it has the effect of being highly safe without being affected by electromagnetic waves from a mobile phone or the like.

  Since the deep body stimulation apparatus of the present invention having a simple structure makes it possible to effectively magnetically stimulate, for example, the deep brain or spinal cord, the reaction due to stimulation of the deep brain or spinal cord can be transmitted from the brain or peripheral effector. By recording, it is possible to evaluate the function of the brain and spinal cord, which is impossible with conventional cortical stimulation, and to diagnose the pathological condition or remove pain. In addition, it is possible to stimulate deep white matter of the cerebrum, basal ganglia, thalamus, hypothalamus, and spinal cord that could only be done by invasive methods such as conventional surgery, and exercise due to brain diseases such as cerebrovascular disorders and Parkinson's disease. In addition to treating dysfunction, alleviating pain, suppressing epileptic seizures, etc., it also has the effect of treating disorders such as immune function and endocrine function, as well as removing spinal pain.

  Next, the present invention will be specifically described with reference to the drawings. In addition, the following description is for making an understanding of this invention easy, and is not restrict | limited to this. That is, arbitrary modifications based on the technical idea of the present invention, changes in the elements of the apparatus, or the entire configuration are possible, and the present invention encompasses all of these. The same applies to the following embodiments.

An open circuit coil is placed in a part of the living body where electrical stimulation is performed, for example, deep in the brain. The meaning of indwelling means indwelling in an isolated and embedded state inside the living body without joining the outside with an electric wire or the like. Although it should just be a magnitude | size large enough to generate the induced electromotive force for performing electrical stimulation, since miniaturization of a coil reduces a patient's burden, it is more preferable. For example, the inner diameter of the open circuit coil can be 5 mm or less and can be formed into a 10-turn coil, but the size and the number of turns of the coil can be changed as necessary. Usually, the output voltage increases as the number of turns increases. The lead wire used for the coil is covered and insulated with a resin that is harmless to the human body, except for the tip.
FIG. 1 is a conceptual explanatory diagram of an indwelling coil. This is merely a conceptual diagram, and as described above, the number of turns of the coil, the diameter of the conducting wire, the inner diameter of the coil, and the like can be arbitrarily designed.

  The indwelling coil is implanted in the body, and a conductive coil tip is fixed to a site requiring stimulation, and then an induced electromotive force is generated in the indwelling coil by an exciting coil installed outside the body. That is, a pulse magnetic field is generated in the indwelling coil from the exciting coil arranged outside, and an induced electromotive force is generated in the indwelling coil. This electromotive force causes a current to flow in the indwelling coil, and it is possible to electrically stimulate a minute part in the body between the terminals of the indwelling coil.

  The method of the present invention is particularly effective for stimulating deep parts of a living body. Of course, it is equally effective in a shallow part of the living body, but in this case, since treatment from outside the living body is possible, there is no need to use the present invention. Moreover, since the meaning of the deep part of the living body is used to mean a site that cannot be easily treated from outside the living body, it should be understood that the depth of the deep part is not particularly meaningful.

  About the open circuit coil indwelled in the site | part which carries out electrical stimulation inside a biological body, it can be set as the some open circuit coil from which an axial direction differs. That is, in this case, it is possible to stimulate a plurality of affected areas at the same time by embedding a plurality of indwelling coils having different directions in the living body. Although the size of the coil is slightly increased with respect to one indwelling coil, it can be made compact, so that the burden on the patient can be reduced accordingly.

  In this case as well, an exciting coil is installed outside the body in order to generate an induced electromotive force in the indwelling coil. In this case, the axial direction of the magnetic field from the exciting coil is changed, and this is effective only for the coils whose directions match. It is possible to generate an induced electromotive force and to electrically stimulate different affected parts in the body. FIG. 2 is an explanatory diagram of this concept. In this case, it is a figure which shows a mode that the coil for excitation was arrange | positioned in 3 directions.

  A deep body stimulation apparatus has a winding portion of an indwelling coil that is insulated and an exposed portion of a winding tip that is drawn out of the indwelling coil. The exposed part can be arbitrarily adjusted according to the shape of the affected part. Moreover, it is desirable to use platinum (Pt) having no cytotoxicity as these conductive materials. However, as long as it is a non-cytotoxic material and has a high workability, it is not particularly limited to platinum, and other metals or alloys can be used.

  It is also effective to configure a resonance circuit for increasing the inductive coil induced voltage by an external magnetic field by combining the indwelling coil and the capacitor. This capacitor is disposed in the internal space of the indwelling coil. As a result, the voltage of the minute indwelling coil can be greatly increased, and the stimulation performance can be enhanced.

As described above, it is necessary to provide a device for generating a pulsed magnetic field in the exciting coil. With this device, a voltage can be induced in the indwelling coil inside the living body, and a minute part in the body can be electrically stimulated. FIG. 3 shows an explanatory diagram in which a device for generating a continuous pulse is attached to an excitation coil together with an indwelling coil provided with a local stimulation electrode and an excitation coil.
As described above, the indwelling coil of the present invention has a limited target for diagnosis and treatment, and can directly apply magnetic stimulation only to that part. Therefore, extra magnetic stimulation is applied to other parts. Since it does not give, there is a big effect also in terms of safety.

Next, various tests up to the present invention will be described.
(Test 1)
When measuring the alternating magnetic field strength with the search coil, the coil output voltage could be increased by about 1 to 2 digits using the resonance between the coil and the capacitor. The result of examining the coil voltage rise due to resonance is shown in FIG. The horizontal axis represents frequency (kHz) and the vertical axis represents search coil output (mV).
FIG. 4 shows “C = 200 pF (292 kHz)” when no capacitor is used and when a capacitor is used. When there is no capacitor, the output of the search coil is less than 2000 mV even if the frequency is raised. However, when the capacitor is used, it can be seen that the output reaches 8000 mV at a frequency of less than 300 kHz.

(Test 2)
Next, assuming an indwelling coil, the output voltage was examined when a capacitor was used for the 10-turn coil and a pulse wave was used. The result is shown in FIG.
The upper stage of FIG. 5 is a case where a ceramic capacitor is used, and the lower stage is a case where an electrolytic capacitor is used. The upper left corner is when no capacitor is used.
As shown in these figures, it can be seen that the output voltage increases with the indwelling coil + capacitor (about 0.1 μF).
In this case, the intensity of the fundamental wave does not change as described above, but it can be seen that the rising voltage of the pulse increases with the addition of the ceramic capacitor 0.03 to 1 μF.

(Test 3)
Next, a pulse wave showing resonance when a capacitor is connected to the indwelling coil is shown in FIG. The left end of the upper stage of FIG. 6 is a case where no capacitor is used.
In this case, the output voltage of the coil was 1.9V. In contrast, the capacitor capacity is 0.27 μF, the coil output voltage is 2.4 V, the capacitor capacity is 0.47 μF, the coil output voltage is 3.0 V, the capacitor capacity is 0.94 μF, and the coil output voltage is 2.V. The coil output voltage was 2.5 V, the capacitor capacitance was 2.55 μF, the capacitor capacitance was 7.65 μF, and the coil output voltage was 2.05 V.

The result of FIG. 6 is shown as a graph in FIG. As is clear from FIG. 7, just because the capacitance of the capacitor is increased, the output voltage of the coil does not increase proportionally. In this example, when the capacitance of the capacitor was 0.47 μF, it was confirmed that the coil output voltage was the highest at 3.0 V and the output voltage was improved by 50%.
Since the output voltage of the coil varies depending on the number of turns and the coil diameter, it can be said that the optimum capacity of the capacitor should be adjusted each time. However, even if the capacity of the capacitor is small, the coil output power can be greatly improved. What can be done is noteworthy and can be said to be particularly suitable for an indwelling coil like the present invention.

Usually, as shown in the explanatory diagram of FIG. 3, assuming that deep brain stimulation is performed, an open circuit indwelling coil for indwelling at a site to be electrically stimulated and an inductive electromotive force for generating the inductive coil Prepare a coil for excitation. The exciting coil is installed outside the body. A continuous pulse power supply is connected to the excitation coil.
In this case, from the above test, it can be said that it is desirable to connect a capacitor to the indwelling coil because the coil output power can be greatly improved. As a result, even a small indwelling coil can increase its output.

(Test 4)
Next, a case where a plurality of open circuit coils having different axial directions are placed at a site for electrical stimulation inside the living body will be described.
In this case, the axes are different in three directions (arrow 1, arrow 2, arrow 3). This conceptual diagram is shown in FIG. FIG. 9 shows an actual product obtained by concretely combining them. In this case, since the indwelling coil is hardened with resin, it is a lump.

FIG. 10 shows a state in which a pulsed magnetic field is generated from an excitation coil installed outside the body and an induced electromotive force is generated in the indwelling coil produced in this way. This makes it possible to change the axial direction of the magnetic field of the excitation coil installed outside the body, generate an effective induced electromotive force only in the indwelling coil with the same direction, and electrically stimulate a minute part in the body. It becomes.
FIG. 11 shows the magnetic flux density when the indwelling coil is provided with an angle. According to this, the difference in magnetic flux density is maximized when the angle is 90 °, which is more preferable.

(Comparative test 1)
In this case, an example in which the direction of the exciting coil and the direction of the indwelling coil are different (there is a deviation of 30 °) is shown. In this case, as shown in FIG. 12, there arises a problem that the output of a specific indwelling coil cannot be increased.
From this, it can be understood that it is necessary to arrange so that the direction of the exciting coil and the direction of the indwelling coil coincide with each other.
However, this means that, by changing the direction of the exciting coil, as shown in Test 4 above, it is possible to increase the output voltage of only a specific indwelling coil and intensively stimulate a specific affected area. It means that.

  The living body deep portion stimulation method and the living body deep portion stimulation apparatus of the present invention only place a coil of a soybean size in the body, so that the burden on the patient can be greatly reduced, and the coil can be reduced by a relatively short operation. Can be implanted in the affected area. In addition, since there is no need to embed batteries, transmitters, wires, etc. in the body, it is possible to reduce the number of reoperations for replacement of these devices, corresponding to the life of the batteries, reducing the failure of the devices. it can. Since the indwelling coil of the present invention does not produce a stimulating effect other than the pulsed magnetic field, it has the effect of being highly safe without being affected by electromagnetic waves from a mobile phone or the like.

  The deep body stimulation method and the deep body stimulation device can stimulate deep white matter of the cerebrum, basal ganglia, thalamus, hypothalamus, and spinal cord, and exercise functions due to brain diseases such as cerebrovascular disorders and Parkinson's disease In addition to treating disorders, alleviating pain, suppressing epileptic seizures, etc., it can also treat disorders such as immune function and endocrine function, and can be used for removing spinal pain.

It is explanatory drawing of the indwelling coil of this invention. It is explanatory drawing of the coil for excitation arrange | positioned in order to generate an induced electromotive force in an indwelling coil. It is explanatory drawing which provided the apparatus which generates an indwelling type coil, a coil for excitation, and a continuous pulse. It is a figure which shows the result of having investigated the coil voltage rise by resonance. It is a figure which shows the result of having investigated the output voltage at the time of using a capacitor | condenser for 10 winding coils and using a pulse wave. It is a figure which shows the pulse wave which shows the resonance at the time of connecting a capacitor | condenser with an indwelling type coil. It is the figure which made the result of FIG. 6 the table | surface. It is the conceptual diagram which made the axis | shaft different in three directions (arrow 1, arrow 2, arrow 3). It is a photograph of the three indwelling coils (actual thing) of the structure shown in FIG. It is a figure which shows a mode that the pulse magnetic field was generated from the coil for excitation installed outside the body, and the induced electromotive force was generated in the said indwelling coil. It is a figure which shows the magnetic flux density at the time of giving an indwelling coil an angle. It is a figure which shows the example in case the direction of the coil for excitation differs from the direction of an indwelling coil.

Claims (8)

  An inductive electromotive force is generated in the indwelling coil by generating an inductive electromotive force in the indwelling coil by generating an inductive electromotive force from an excitation coil placed outside the body, and indwelling the open circuit coil in the living body. A method for deeply stimulating a living body, characterized by electrically stimulating a minute part in the body through a coil.   A plurality of open circuit coils with different axial directions are placed at the site of electrical stimulation inside the living body, and a pulsed magnetic field is generated from the excitation coil installed outside the body for the placement coil and guided to the placement coil. In addition to generating an electromotive force, the axial direction of the magnetic field of the excitation coil installed outside the body is changed, and an effective induced electromotive force is generated only in the indwelling coil having the same direction to electrically stimulate a minute part in the body. A method for stimulating a deep part of a living body.   The wound portion of the indwelling coil is insulated and coated, the tip portion of the winding drawn from the indwelling coil is exposed, and a minute portion in the body is electrically stimulated through the tip portion. 2. A method for deep stimulation of a living body according to 2.   4. A resonance circuit is configured by combining an indwelling coil and a capacitor, the inductive coil induced voltage is increased by an external magnetic field, and a minute part in the body is electrically stimulated. 2. A method for stimulating a deep part of a living body according to 1.   It has an open circuit coil placed in the site of electrical stimulation inside the living body and an excitation coil installed outside the body for generating an induced electromotive force in the placement coil, and generates a pulse magnetic field from the excitation coil. A deep body stimulation apparatus characterized in that an induced electromotive force is generated in the indwelling coil, and a minute part in the body is electrically stimulated through the indwelling coil by the electromotive force.   A plurality of open-circuit indwelling coils with different axial directions placed in a site to be electrically stimulated inside a living body, and an excitation coil installed outside the body for generating a pulsed magnetic field in the indwelling coil, from the excitation coil A pulsed magnetic field is generated and the axial direction of the magnetic field is changed to generate an induced electromotive force that is effective only in the coils having the same direction, thereby electrically stimulating a minute part in the body. Stimulator.   It has a winding part of an indwelling coil coated with insulation and an exposed part of a winding tip drawn out from the indwelling coil, and electrically stimulates a minute part in the body through the exposed part of the tip. The deep body stimulation apparatus according to claim 5 or 6.   The combination of the indwelling coil and the capacitor constitutes a resonance circuit for increasing the indwelling coil induced voltage by an external magnetic field, and electrically stimulates a minute part in the body. The deep body stimulation apparatus according to one item.