JP2010006762A5 - - Google Patents
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- Publication number
- JP2010006762A5 JP2010006762A5 JP2008169211A JP2008169211A JP2010006762A5 JP 2010006762 A5 JP2010006762 A5 JP 2010006762A5 JP 2008169211 A JP2008169211 A JP 2008169211A JP 2008169211 A JP2008169211 A JP 2008169211A JP 2010006762 A5 JP2010006762 A5 JP 2010006762A5
- Authority
- JP
- Japan
- Prior art keywords
- fentanyl
- decomposition product
- transdermal patch
- ascorbyl palmitate
- primary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 12
- 229960002428 fentanyl Drugs 0.000 claims 12
- 238000000354 decomposition reaction Methods 0.000 claims 8
- QAQJMLQRFWZOBN-UHFFFAOYSA-N 2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)C1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-UHFFFAOYSA-N 0.000 claims 4
- 235000000072 L-ascorbyl-6-palmitate Nutrition 0.000 claims 4
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 4
- 239000000853 adhesive Substances 0.000 claims 3
- 230000001070 adhesive effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000011505 plaster Substances 0.000 claims 3
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
- ZTHRQJQJODGZHV-UHFFFAOYSA-N n-phenylpropanamide Chemical compound CCC(=O)NC1=CC=CC=C1 ZTHRQJQJODGZHV-UHFFFAOYSA-N 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- -1 1-phenethyl-2-oxopiperidin-4-yl Chemical group 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- YXTQWUUFSXJPBR-UHFFFAOYSA-N n-(1-hydroxypiperidin-4-yl)-n-phenylpropanamide Chemical compound C=1C=CC=CC=1N(C(=O)CC)C1CCN(O)CC1 YXTQWUUFSXJPBR-UHFFFAOYSA-N 0.000 claims 1
- RYSCOBQROPDNKR-UHFFFAOYSA-N n-[1-oxido-1-(2-phenylethyl)piperidin-1-ium-4-yl]-n-phenylpropanamide Chemical group C=1C=CC=CC=1N(C(=O)CC)C(CC1)CC[N+]1([O-])CCC1=CC=CC=C1 RYSCOBQROPDNKR-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008169211A JP4856125B2 (ja) | 2008-06-27 | 2008-06-27 | 安定化されたフェンタニルまたはその塩含有組成物及びこれを用いた医薬製剤並びにフェンタニルまたはその塩の安定化方法 |
| CN2009801246133A CN102076340B (zh) | 2008-06-27 | 2009-06-29 | 含芬太尼或其盐的经皮吸收型贴剂 |
| PCT/JP2009/061853 WO2009157586A1 (ja) | 2008-06-27 | 2009-06-29 | フェンタニルまたはその塩含有経皮吸収型貼付剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008169211A JP4856125B2 (ja) | 2008-06-27 | 2008-06-27 | 安定化されたフェンタニルまたはその塩含有組成物及びこれを用いた医薬製剤並びにフェンタニルまたはその塩の安定化方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010006762A JP2010006762A (ja) | 2010-01-14 |
| JP2010006762A5 true JP2010006762A5 (enExample) | 2011-06-16 |
| JP4856125B2 JP4856125B2 (ja) | 2012-01-18 |
Family
ID=41587661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008169211A Active JP4856125B2 (ja) | 2008-06-27 | 2008-06-27 | 安定化されたフェンタニルまたはその塩含有組成物及びこれを用いた医薬製剤並びにフェンタニルまたはその塩の安定化方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4856125B2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201404167QA (en) * | 2009-07-24 | 2014-10-30 | Teikoku Seiyaku Kk | Fentanyl-containing adhesive preparation for external use |
| WO2017073516A1 (ja) * | 2015-10-26 | 2017-05-04 | 久光製薬株式会社 | 貼付剤 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9213322D0 (en) * | 1992-06-23 | 1992-08-05 | Efamol Holdings | Antioxidant compositions |
| JPH07277917A (ja) * | 1994-04-01 | 1995-10-24 | Nisshin Oil Mills Ltd:The | 酸化安定性の良い化粧料 |
| JP3836566B2 (ja) * | 1996-05-13 | 2006-10-25 | 久光製薬株式会社 | フェンタニル含有経皮投与テープ製剤 |
| JP4205778B2 (ja) * | 1998-04-17 | 2009-01-07 | 久光製薬株式会社 | 貼付製剤 |
| ATE485815T1 (de) * | 1999-04-13 | 2010-11-15 | Hisamitsu Pharmaceutical Co | Zubereitungen zur perkutanen absorption |
| US6353029B1 (en) * | 2000-08-24 | 2002-03-05 | Bristol-Myers Squibb Company | Storage stable tretinoin and 4-hydroxyanisole containing topical composition |
| JP5114042B2 (ja) * | 2005-10-19 | 2013-01-09 | ニプロパッチ株式会社 | 貼付剤、及び貼付剤の製造方法 |
-
2008
- 2008-06-27 JP JP2008169211A patent/JP4856125B2/ja active Active
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